<110>    Seoul National University R&DB Foundation
         Logone Bio Convergence Research Foundation

<120>    Type 1 interferon neutralizing Fc-fusion proteins and uses
         thereof

<130>    OP19-0213/PCT

<150>    KR 10-2018-0168801
<151>    2018-12-24

<160>    76

<170>    KoPatentIn 3.0

<210>    1
<211>    69
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Kozak-Signal sequence


<400>    1
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcc                                                                 69


<210>    2
<211>    23
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Kozak-Signal sequence


<400>    2
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala
             20            


<210>    3
<211>    1227
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR1 ExtraCellular Domain


<400>    3
aagaacctga agtcccctca gaaagtggaa gtggacatca tcgacgacaa cttcatcctg         60

cggtggaaca gatccgacga gtccgtgggc aacgtgacct tcagcttcga ctaccagaaa        120

accggcatgg acaactggat caagctgtcc ggctgccaga acatcacctc taccaagtgc        180

aacttctcca gcctgaagct gaacgtgtac gaggaaatca agctgcggat ccgggccgag        240

aaagagaaca ccagcagttg gtacgaggtg gacagcttca cccctttcag aaaggcccag        300

atcggccctc ctgaagtgca cctggaagcc gaggataagg ccatcgtgat ccacatcagc        360

cccggcacca aggactctgt gatgtgggct ctcgacggcc tgtccttcac ctacagcctg        420

gtcatctgga agaactcctc cggcgtggaa gagagaatcg agaacatcta ctcccggcac        480

aagatctaca agctgagccc cgagacaacc tactgcctga aagtgaaggc cgctctgctg        540

acctcctgga agatcggcgt gtactctccc gtgcactgca tcaagaccac cgtggaaaac        600

gagctgcctc ctccagagaa catcgaggtg tccgtgcaga accagaacta cgtgctgaag        660

tgggactaca cctacgccaa catgaccttt caggtgcagt ggctgcacgc ttttctgaag        720

cggaaccctg gcaaccacct gtacaagtgg aagcagattc ccgactgcga gaacgtgaaa        780

accacacagt gcgtgttccc tcagaacgtg ttccagaagg gcatctacct gctgagagtg        840

caggcctccg acggcaacaa caccagcttt tggagcgaag agatcaagtt cgataccgag        900

atccaggcct tcctgctgcc tccagtgttc aacatcagat ccctgtccga ctccttccac        960

atctacatcg gcgctcctaa gcagtccggc aacacccctg tgatccagga ctaccctctg       1020

atctacgaga tcatcttctg ggagaacacc tccaacgccg agcggaagat catcgagaag       1080

aaaaccgacg tgaccgtgcc taacctgaag cctctgaccg tgtactgcgt gaaggctagg       1140

gcccacacca tggacgaaaa gctgaacaag tcctccgtgt tctccgacgc cgtgtgcgaa       1200

aagaccaagc caggcaacac ctctaaa                                           1227


<210>    4
<211>    409
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR1 ExtraCellular Domain


<400>    4
Lys Asn Leu Lys Ser Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp
  1               5                  10                  15 

Asn Phe Ile Leu Arg Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val
             20                  25                  30 

Thr Phe Ser Phe Asp Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys
         35                  40                  45 

Leu Ser Gly Cys Gln Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser
     50                  55                  60 

Leu Lys Leu Asn Val Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu
 65                  70                  75                  80 

Lys Glu Asn Thr Ser Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe
                 85                  90                  95 

Arg Lys Ala Gln Ile Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp
            100                 105                 110 

Lys Ala Ile Val Ile His Ile Ser Pro Gly Thr Lys Asp Ser Val Met
        115                 120                 125 

Trp Ala Leu Asp Gly Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys
    130                 135                 140 

Asn Ser Ser Gly Val Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His
145                 150                 155                 160 

Lys Ile Tyr Lys Leu Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys
                165                 170                 175 

Ala Ala Leu Leu Thr Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His
            180                 185                 190 

Cys Ile Lys Thr Thr Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile
        195                 200                 205 

Glu Val Ser Val Gln Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr
    210                 215                 220 

Tyr Ala Asn Met Thr Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys
225                 230                 235                 240 

Arg Asn Pro Gly Asn His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys
                245                 250                 255 

Glu Asn Val Lys Thr Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln
            260                 265                 270 

Lys Gly Ile Tyr Leu Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr
        275                 280                 285 

Ser Phe Trp Ser Glu Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe
    290                 295                 300 

Leu Leu Pro Pro Val Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His
305                 310                 315                 320 

Ile Tyr Ile Gly Ala Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln
                325                 330                 335 

Asp Tyr Pro Leu Ile Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn
            340                 345                 350 

Ala Glu Arg Lys Ile Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn
        355                 360                 365 

Leu Lys Pro Leu Thr Val Tyr Cys Val Lys Ala Arg Ala His Thr Met
    370                 375                 380 

Asp Glu Lys Leu Asn Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu
385                 390                 395                 400 

Lys Thr Lys Pro Gly Asn Thr Ser Lys
                405                


<210>    5
<211>    651
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR2 ExtraCellular Domain


<400>    5
atctcctacg acagccctga ctacaccgac gagtcctgca ccttcaagat ctccctgcgg         60

aacttccggt ccatcctgtc ctgggagctg aagaaccact ccatcgtgcc cacacactac        120

accctgctgt acaccatcat gtccaagcct gaggacctga aggtggtcaa gaactgcgcc        180

aacaccacca gatctttctg cgacctgacc gatgagtggc ggtctaccca cgaggcttac        240

gtgacagtgc tggaaggctt ctccggcaat accacactgt tcagctgctc ccacaacttc        300

tggctggcca tcgacatgtc cttcgagcct ccagagttcg agatcgtggg cttcaccaac        360

cacatcaacg tgatggtcaa gttccccagc atcgtggaag aggaactcca gttcgacctg        420

agcctggtca tcgaggaaca gtccgagggc atcgtgaaga agcacaagcc cgagatcaag        480

ggcaacatgt ccggcaactt cacctacatc atcgacaagc tgatccccaa caccaactac        540

tgcgtgtccg tgtacctgga acactccgat gagcaggccg tgatcaagtc ccctctgaag        600

tgtaccctgc tgcctcctgg ccaagagtct gagtctgccg agtctgctaa a                 651


<210>    6
<211>    217
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR2 ExtraCellular Domain


<400>    6
Ile Ser Tyr Asp Ser Pro Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys
  1               5                  10                  15 

Ile Ser Leu Arg Asn Phe Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn
             20                  25                  30 

His Ser Ile Val Pro Thr His Tyr Thr Leu Leu Tyr Thr Ile Met Ser
         35                  40                  45 

Lys Pro Glu Asp Leu Lys Val Val Lys Asn Cys Ala Asn Thr Thr Arg
     50                  55                  60 

Ser Phe Cys Asp Leu Thr Asp Glu Trp Arg Ser Thr His Glu Ala Tyr
 65                  70                  75                  80 

Val Thr Val Leu Glu Gly Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys
                 85                  90                  95 

Ser His Asn Phe Trp Leu Ala Ile Asp Met Ser Phe Glu Pro Pro Glu
            100                 105                 110 

Phe Glu Ile Val Gly Phe Thr Asn His Ile Asn Val Met Val Lys Phe
        115                 120                 125 

Pro Ser Ile Val Glu Glu Glu Leu Gln Phe Asp Leu Ser Leu Val Ile
    130                 135                 140 

Glu Glu Gln Ser Glu Gly Ile Val Lys Lys His Lys Pro Glu Ile Lys
145                 150                 155                 160 

Gly Asn Met Ser Gly Asn Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro
                165                 170                 175 

Asn Thr Asn Tyr Cys Val Ser Val Tyr Leu Glu His Ser Asp Glu Gln
            180                 185                 190 

Ala Val Ile Lys Ser Pro Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln
        195                 200                 205 

Glu Ser Glu Ser Ala Glu Ser Ala Lys
    210                 215        


<210>    7
<211>    696
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    FC-WT


<400>    7
cccaagagct gcgacaagac ccacacctgt cccccctgcc ctgcccctga actgctgggc         60

ggacccagcg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat cagccggacc        120

cccgaagtga cctgcgtggt ggtggacgtg tcccacgagg accctgaagt gaagttcaat        180

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcccagaga ggaacagtac        240

aacagcacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc        300

aaagagtaca agtgcaaggt gtccaacaag gccctgcctg cccccatcga gaaaaccatc        360

agcaaggcca agggccagcc ccgcgagccc caggtgtaca cactgccccc cagccgggac        420

gagctgacca agaaccaggt gtccctgacc tgcctggtga aaggcttcta ccccagcgat        480

atcgccgtgg aatgggagag caacggccag cccgagaaca actacaagac caccccccct        540

gtgctggaca gcgacggctc attcttcctg tacagcaagc tgaccgtgga caagagccgg        600

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac        660

acccagaagt ccctgagcct gagccccggc aagtag                                  696


<210>    8
<211>    231
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    FC-WT


<400>    8
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
  1               5                  10                  15 

Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
             20                  25                  30 

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
         35                  40                  45 

Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
     50                  55                  60 

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
 65                  70                  75                  80 

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                 85                  90                  95 

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
            100                 105                 110 

Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
        115                 120                 125 

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
    130                 135                 140 

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
145                 150                 155                 160 

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
                165                 170                 175 

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
            180                 185                 190 

Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
        195                 200                 205 

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
    210                 215                 220 

Leu Ser Leu Ser Pro Gly Lys
225                 230    


<210>    9
<211>    18
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Linker


<400>    9
atcgagggcc ggatggac                                                       18


<210>    10
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker


<400>    10
Ile Glu Gly Arg Met Asp
  1               5    


<210>    11
<211>    696
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    FC-EW


<400>    11
cccaagagct gcgacaagac ccacacctgt cccccctgcc ctgcccctga actgctgggc         60

ggacccagcg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat cagccggacc        120

cccgaagtga cctgcgtggt ggtggacgtg tcccacgagg accctgaagt gaagttcaat        180

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcccagaga ggaacagtac        240

aacagcacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc        300

aaagagtaca agtgcaaggt gtccaacaag gccctgcctg cccccatcga gaaaaccatc        360

agcaaggcca agggccagcc ccgcgagccc caggtgtaca cactgccccc cagccgggac        420

gagctgaccg agaaccaggt gtccctgacc tgcctggtga aaggcttcta ccccagcgat        480

atcgccgtgg aatgggagag caacggccag cccgagaaca actacaagac caccccccct        540

gtgctggaca gcgacggctc attcttcctg tacagctggc tgaccgtgga caagagccgg        600

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac        660

acccagaagt ccctgagcct gagccccggc aagtag                                  696


<210>    12
<211>    231
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    FC-EW


<400>    12
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
  1               5                  10                  15 

Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
             20                  25                  30 

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
         35                  40                  45 

Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
     50                  55                  60 

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
 65                  70                  75                  80 

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                 85                  90                  95 

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
            100                 105                 110 

Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
        115                 120                 125 

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Glu
    130                 135                 140 

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
145                 150                 155                 160 

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
                165                 170                 175 

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
            180                 185                 190 

Trp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
        195                 200                 205 

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
    210                 215                 220 

Leu Ser Leu Ser Pro Gly Lys
225                 230    


<210>    13
<211>    696
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    FC-RVT


<400>    13
cccaagagct gcgacaagac ccacacctgt cccccctgcc ctgcccctga actgctgggc         60

ggacccagcg tgttcctgtt ccccccaaag cccaaggaca ccctgatgat cagccggacc        120

cccgaagtga cctgcgtggt ggtggacgtg tcccacgagg accctgaagt gaagttcaat        180

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcccagaga ggaacagtac        240

aacagcacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc        300

aaagagtaca agtgcaaggt gtccaacaag gccctgcctg cccccatcga gaaaaccatc        360

agcaaggcca agggccagcc ccgcgagccc cgggtgtaca cactgccccc cagccgggac        420

gagctgacca agaaccaggt gtccctgacc tgcctggtga aaggcttcta ccccagcgat        480

atcgccgtgg aatgggagag caacggccag cccgagaaca actacaagac caccccccct        540

gtgctggtca gcgacggctc attcaccctg tacagcaagc tgaccgtgga caagagccgg        600

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac        660

acccagaagt ccctgagcct gagccccggc aagtag                                  696


<210>    14
<211>    231
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    FC-RVT


<400>    14
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
  1               5                  10                  15 

Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
             20                  25                  30 

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
         35                  40                  45 

Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
     50                  55                  60 

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
 65                  70                  75                  80 

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                 85                  90                  95 

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
            100                 105                 110 

Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
        115                 120                 125 

Glu Pro Arg Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
    130                 135                 140 

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
145                 150                 155                 160 

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
                165                 170                 175 

Thr Thr Pro Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu Tyr Ser
            180                 185                 190 

Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
        195                 200                 205 

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
    210                 215                 220 

Leu Ser Leu Ser Pro Gly Lys
225                 230    


<210>    15
<211>    783
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Linker-FC WT


<400>    15
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca tcgagggccg gatggacccc aagagctgcg acaagaccca cacctgtccc        120

ccctgccctg cccctgaact gctgggcgga cccagcgtgt tcctgttccc cccaaagccc        180

aaggacaccc tgatgatcag ccggaccccc gaagtgacct gcgtggtggt ggacgtgtcc        240

cacgaggacc ctgaagtgaa gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc        300

aagaccaagc ccagagagga acagtacaac agcacctacc gggtggtgtc cgtgctgacc        360

gtgctgcacc aggactggct gaacggcaaa gagtacaagt gcaaggtgtc caacaaggcc        420

ctgcctgccc ccatcgagaa aaccatcagc aaggccaagg gccagccccg cgagccccag        480

gtgtacacac tgccccccag ccgggacgag ctgaccaaga accaggtgtc cctgacctgc        540

ctggtgaaag gcttctaccc cagcgatatc gccgtggaat gggagagcaa cggccagccc        600

gagaacaact acaagaccac cccccctgtg ctggacagcg acggctcatt cttcctgtac        660

agcaagctga ccgtggacaa gagccggtgg cagcagggca acgtgttcag ctgcagcgtg        720

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgagcctgag ccccggcaag        780

tga                                                                      783


<210>    16
<211>    260
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker-FC WT


<400>    16
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Ile Glu Gly Arg Met Asp Pro Lys Ser
             20                  25                  30 

Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
         35                  40                  45 

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
     50                  55                  60 

Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
 65                  70                  75                  80 

His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                 85                  90                  95 

Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            100                 105                 110 

Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        115                 120                 125 

Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    130                 135                 140 

Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
145                 150                 155                 160 

Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
                165                 170                 175 

Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            180                 185                 190 

Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        195                 200                 205 

Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    210                 215                 220 

Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
225                 230                 235                 240 

Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                245                 250                 255 

Ser Pro Gly Lys
            260


<210>    17
<211>    783
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Linker-FC EW


<400>    17
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca tcgagggccg gatggacccc aagagctgcg acaagaccca cacctgtccc        120

ccctgccctg cccctgaact gctgggcgga cccagcgtgt tcctgttccc cccaaagccc        180

aaggacaccc tgatgatcag ccggaccccc gaagtgacct gcgtggtggt ggacgtgtcc        240

cacgaggacc ctgaagtgaa gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc        300

aagaccaagc ccagagagga acagtacaac agcacctacc gggtggtgtc cgtgctgacc        360

gtgctgcacc aggactggct gaacggcaaa gagtacaagt gcaaggtgtc caacaaggcc        420

ctgcctgccc ccatcgagaa aaccatcagc aaggccaagg gccagccccg cgagccccag        480

gtgtacacac tgccccccag ccgggacgag ctgaccgaga accaggtgtc cctgacctgc        540

ctggtgaaag gcttctaccc cagcgatatc gccgtggaat gggagagcaa cggccagccc        600

gagaacaact acaagaccac cccccctgtg ctggacagcg acggctcatt cttcctgtac        660

agctggctga ccgtggacaa gagccggtgg cagcagggca acgtgttcag ctgcagcgtg        720

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgagcctgag ccccggcaag        780

tag                                                                      783


<210>    18
<211>    260
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker-FC EW


<400>    18
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Ile Glu Gly Arg Met Asp Pro Lys Ser
             20                  25                  30 

Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
         35                  40                  45 

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
     50                  55                  60 

Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
 65                  70                  75                  80 

His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                 85                  90                  95 

Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            100                 105                 110 

Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        115                 120                 125 

Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    130                 135                 140 

Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
145                 150                 155                 160 

Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Glu Asn Gln Val
                165                 170                 175 

Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            180                 185                 190 

Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        195                 200                 205 

Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Trp Leu Thr
    210                 215                 220 

Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
225                 230                 235                 240 

Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                245                 250                 255 

Ser Pro Gly Lys
            260


<210>    19
<211>    783
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Linker-FC RVT


<400>    19
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca tcgagggccg gatggacccc aagagctgcg acaagaccca cacctgtccc        120

ccctgccctg cccctgaact gctgggcgga cccagcgtgt tcctgttccc cccaaagccc        180

aaggacaccc tgatgatcag ccggaccccc gaagtgacct gcgtggtggt ggacgtgtcc        240

cacgaggacc ctgaagtgaa gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc        300

aagaccaagc ccagagagga acagtacaac agcacctacc gggtggtgtc cgtgctgacc        360

gtgctgcacc aggactggct gaacggcaaa gagtacaagt gcaaggtgtc caacaaggcc        420

ctgcctgccc ccatcgagaa aaccatcagc aaggccaagg gccagccccg cgagccccgg        480

gtgtacacac tgccccccag ccgggacgag ctgaccaaga accaggtgtc cctgacctgc        540

ctggtgaaag gcttctaccc cagcgatatc gccgtggaat gggagagcaa cggccagccc        600

gagaacaact acaagaccac cccccctgtg ctggtcagcg acggctcatt caccctgtac        660

agcaagctga ccgtggacaa gagccggtgg cagcagggca acgtgttcag ctgcagcgtg        720

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgagcctgag ccccggcaag        780

tag                                                                      783


<210>    20
<211>    260
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker-FC RVT


<400>    20
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Ile Glu Gly Arg Met Asp Pro Lys Ser
             20                  25                  30 

Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
         35                  40                  45 

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
     50                  55                  60 

Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
 65                  70                  75                  80 

His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                 85                  90                  95 

Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            100                 105                 110 

Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        115                 120                 125 

Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    130                 135                 140 

Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Arg
145                 150                 155                 160 

Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
                165                 170                 175 

Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            180                 185                 190 

Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        195                 200                 205 

Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu Tyr Ser Lys Leu Thr
    210                 215                 220 

Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
225                 230                 235                 240 

Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                245                 250                 255 

Ser Pro Gly Lys
            260


<210>    21
<211>    2010
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker-FC WT


<400>    21
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca agaacctgaa gtcccctcag aaagtggaag tggacatcat cgacgacaac        120

ttcatcctgc ggtggaacag atccgacgag tccgtgggca acgtgacctt cagcttcgac        180

taccagaaaa ccggcatgga caactggatc aagctgtccg gctgccagaa catcacctct        240

accaagtgca acttctccag cctgaagctg aacgtgtacg aggaaatcaa gctgcggatc        300

cgggccgaga aagagaacac cagcagttgg tacgaggtgg acagcttcac ccctttcaga        360

aaggcccaga tcggccctcc tgaagtgcac ctggaagccg aggataaggc catcgtgatc        420

cacatcagcc ccggcaccaa ggactctgtg atgtgggctc tcgacggcct gtccttcacc        480

tacagcctgg tcatctggaa gaactcctcc ggcgtggaag agagaatcga gaacatctac        540

tcccggcaca agatctacaa gctgagcccc gagacaacct actgcctgaa agtgaaggcc        600

gctctgctga cctcctggaa gatcggcgtg tactctcccg tgcactgcat caagaccacc        660

gtggaaaacg agctgcctcc tccagagaac atcgaggtgt ccgtgcagaa ccagaactac        720

gtgctgaagt gggactacac ctacgccaac atgacctttc aggtgcagtg gctgcacgct        780

tttctgaagc ggaaccctgg caaccacctg tacaagtgga agcagattcc cgactgcgag        840

aacgtgaaaa ccacacagtg cgtgttccct cagaacgtgt tccagaaggg catctacctg        900

ctgagagtgc aggcctccga cggcaacaac accagctttt ggagcgaaga gatcaagttc        960

gataccgaga tccaggcctt cctgctgcct ccagtgttca acatcagatc cctgtccgac       1020

tccttccaca tctacatcgg cgctcctaag cagtccggca acacccctgt gatccaggac       1080

taccctctga tctacgagat catcttctgg gagaacacct ccaacgccga gcggaagatc       1140

atcgagaaga aaaccgacgt gaccgtgcct aacctgaagc ctctgaccgt gtactgcgtg       1200

aaggctaggg cccacaccat ggacgaaaag ctgaacaagt cctccgtgtt ctccgacgcc       1260

gtgtgcgaaa agaccaagcc aggcaacacc tctaaaatcg agggccggat ggaccccaag       1320

agctgcgaca agacccacac ctgtcccccc tgccctgccc ctgaactgct gggcggaccc       1380

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa       1440

gtgacctgcg tggtggtgga cgtgtcccac gaggaccctg aagtgaagtt caattggtac       1500

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc       1560

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag       1620

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgagaaaac catcagcaag       1680

gccaagggcc agccccgcga gccccaggtg tacacactgc cccccagccg ggacgagctg       1740

accaagaacc aggtgtccct gacctgcctg gtgaaaggct tctaccccag cgatatcgcc       1800

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg       1860

gacagcgacg gctcattctt cctgtacagc aagctgaccg tggacaagag ccggtggcag       1920

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag       1980

aagtccctga gcctgagccc cggcaagtga                                        2010


<210>    22
<211>    669
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker-FC WT


<400>    22
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Lys Asn Leu Lys Ser Pro Gln Lys Val
             20                  25                  30 

Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg Trp Asn Arg Ser
         35                  40                  45 

Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp Tyr Gln Lys Thr
     50                  55                  60 

Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln Asn Ile Thr Ser
 65                  70                  75                  80 

Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val Tyr Glu Glu Ile
                 85                  90                  95 

Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser Ser Trp Tyr Glu
            100                 105                 110 

Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile Gly Pro Pro Glu
        115                 120                 125 

Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile His Ile Ser Pro
    130                 135                 140 

Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly Leu Ser Phe Thr
145                 150                 155                 160 

Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val Glu Glu Arg Ile
                165                 170                 175 

Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu Ser Pro Glu Thr
            180                 185                 190 

Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr Ser Trp Lys Ile
        195                 200                 205 

Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr Val Glu Asn Glu
    210                 215                 220 

Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln Asn Gln Asn Tyr
225                 230                 235                 240 

Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr Phe Gln Val Gln
                245                 250                 255 

Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn His Leu Tyr Lys
            260                 265                 270 

Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr Thr Gln Cys Val
        275                 280                 285 

Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu Leu Arg Val Gln
    290                 295                 300 

Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu Glu Ile Lys Phe
305                 310                 315                 320 

Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val Phe Asn Ile Arg
                325                 330                 335 

Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala Pro Lys Gln Ser
            340                 345                 350 

Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile Tyr Glu Ile Ile
        355                 360                 365 

Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile Ile Glu Lys Lys
    370                 375                 380 

Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr Val Tyr Cys Val
385                 390                 395                 400 

Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn Lys Ser Ser Val
                405                 410                 415 

Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly Asn Thr Ser Lys
            420                 425                 430 

Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys
        435                 440                 445 

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
    450                 455                 460 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
465                 470                 475                 480 

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                485                 490                 495 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            500                 505                 510 

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        515                 520                 525 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    530                 535                 540 

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
545                 550                 555                 560 

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                565                 570                 575 

Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            580                 585                 590 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        595                 600                 605 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    610                 615                 620 

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
625                 630                 635                 640 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                645                 650                 655 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            660                 665                


<210>    23
<211>    2010
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker-FC EW


<400>    23
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca agaacctgaa gtcccctcag aaagtggaag tggacatcat cgacgacaac        120

ttcatcctgc ggtggaacag atccgacgag tccgtgggca acgtgacctt cagcttcgac        180

taccagaaaa ccggcatgga caactggatc aagctgtccg gctgccagaa catcacctct        240

accaagtgca acttctccag cctgaagctg aacgtgtacg aggaaatcaa gctgcggatc        300

cgggccgaga aagagaacac cagcagttgg tacgaggtgg acagcttcac ccctttcaga        360

aaggcccaga tcggccctcc tgaagtgcac ctggaagccg aggataaggc catcgtgatc        420

cacatcagcc ccggcaccaa ggactctgtg atgtgggctc tcgacggcct gtccttcacc        480

tacagcctgg tcatctggaa gaactcctcc ggcgtggaag agagaatcga gaacatctac        540

tcccggcaca agatctacaa gctgagcccc gagacaacct actgcctgaa agtgaaggcc        600

gctctgctga cctcctggaa gatcggcgtg tactctcccg tgcactgcat caagaccacc        660

gtggaaaacg agctgcctcc tccagagaac atcgaggtgt ccgtgcagaa ccagaactac        720

gtgctgaagt gggactacac ctacgccaac atgacctttc aggtgcagtg gctgcacgct        780

tttctgaagc ggaaccctgg caaccacctg tacaagtgga agcagattcc cgactgcgag        840

aacgtgaaaa ccacacagtg cgtgttccct cagaacgtgt tccagaaggg catctacctg        900

ctgagagtgc aggcctccga cggcaacaac accagctttt ggagcgaaga gatcaagttc        960

gataccgaga tccaggcctt cctgctgcct ccagtgttca acatcagatc cctgtccgac       1020

tccttccaca tctacatcgg cgctcctaag cagtccggca acacccctgt gatccaggac       1080

taccctctga tctacgagat catcttctgg gagaacacct ccaacgccga gcggaagatc       1140

atcgagaaga aaaccgacgt gaccgtgcct aacctgaagc ctctgaccgt gtactgcgtg       1200

aaggctaggg cccacaccat ggacgaaaag ctgaacaagt cctccgtgtt ctccgacgcc       1260

gtgtgcgaaa agaccaagcc aggcaacacc tctaaaatcg agggccggat ggaccccaag       1320

agctgcgaca agacccacac ctgtcccccc tgccctgccc ctgaactgct gggcggaccc       1380

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa       1440

gtgacctgcg tggtggtgga cgtgtcccac gaggaccctg aagtgaagtt caattggtac       1500

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc       1560

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag       1620

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgagaaaac catcagcaag       1680

gccaagggcc agccccgcga gccccaggtg tacacactgc cccccagccg ggacgagctg       1740

accgagaacc aggtgtccct gacctgcctg gtgaaaggct tctaccccag cgatatcgcc       1800

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg       1860

gacagcgacg gctcattctt cctgtacagc tggctgaccg tggacaagag ccggtggcag       1920

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag       1980

aagtccctga gcctgagccc cggcaagtag                                        2010


<210>    24
<211>    669
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker-FC EW


<400>    24
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Lys Asn Leu Lys Ser Pro Gln Lys Val
             20                  25                  30 

Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg Trp Asn Arg Ser
         35                  40                  45 

Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp Tyr Gln Lys Thr
     50                  55                  60 

Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln Asn Ile Thr Ser
 65                  70                  75                  80 

Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val Tyr Glu Glu Ile
                 85                  90                  95 

Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser Ser Trp Tyr Glu
            100                 105                 110 

Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile Gly Pro Pro Glu
        115                 120                 125 

Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile His Ile Ser Pro
    130                 135                 140 

Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly Leu Ser Phe Thr
145                 150                 155                 160 

Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val Glu Glu Arg Ile
                165                 170                 175 

Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu Ser Pro Glu Thr
            180                 185                 190 

Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr Ser Trp Lys Ile
        195                 200                 205 

Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr Val Glu Asn Glu
    210                 215                 220 

Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln Asn Gln Asn Tyr
225                 230                 235                 240 

Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr Phe Gln Val Gln
                245                 250                 255 

Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn His Leu Tyr Lys
            260                 265                 270 

Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr Thr Gln Cys Val
        275                 280                 285 

Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu Leu Arg Val Gln
    290                 295                 300 

Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu Glu Ile Lys Phe
305                 310                 315                 320 

Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val Phe Asn Ile Arg
                325                 330                 335 

Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala Pro Lys Gln Ser
            340                 345                 350 

Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile Tyr Glu Ile Ile
        355                 360                 365 

Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile Ile Glu Lys Lys
    370                 375                 380 

Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr Val Tyr Cys Val
385                 390                 395                 400 

Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn Lys Ser Ser Val
                405                 410                 415 

Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly Asn Thr Ser Lys
            420                 425                 430 

Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys
        435                 440                 445 

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
    450                 455                 460 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
465                 470                 475                 480 

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                485                 490                 495 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            500                 505                 510 

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        515                 520                 525 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    530                 535                 540 

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
545                 550                 555                 560 

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                565                 570                 575 

Arg Asp Glu Leu Thr Glu Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            580                 585                 590 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        595                 600                 605 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    610                 615                 620 

Ser Phe Phe Leu Tyr Ser Trp Leu Thr Val Asp Lys Ser Arg Trp Gln
625                 630                 635                 640 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                645                 650                 655 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            660                 665                


<210>    25
<211>    2010
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker-FC RVT


<400>    25
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca agaacctgaa gtcccctcag aaagtggaag tggacatcat cgacgacaac        120

ttcatcctgc ggtggaacag atccgacgag tccgtgggca acgtgacctt cagcttcgac        180

taccagaaaa ccggcatgga caactggatc aagctgtccg gctgccagaa catcacctct        240

accaagtgca acttctccag cctgaagctg aacgtgtacg aggaaatcaa gctgcggatc        300

cgggccgaga aagagaacac cagcagttgg tacgaggtgg acagcttcac ccctttcaga        360

aaggcccaga tcggccctcc tgaagtgcac ctggaagccg aggataaggc catcgtgatc        420

cacatcagcc ccggcaccaa ggactctgtg atgtgggctc tcgacggcct gtccttcacc        480

tacagcctgg tcatctggaa gaactcctcc ggcgtggaag agagaatcga gaacatctac        540

tcccggcaca agatctacaa gctgagcccc gagacaacct actgcctgaa agtgaaggcc        600

gctctgctga cctcctggaa gatcggcgtg tactctcccg tgcactgcat caagaccacc        660

gtggaaaacg agctgcctcc tccagagaac atcgaggtgt ccgtgcagaa ccagaactac        720

gtgctgaagt gggactacac ctacgccaac atgacctttc aggtgcagtg gctgcacgct        780

tttctgaagc ggaaccctgg caaccacctg tacaagtgga agcagattcc cgactgcgag        840

aacgtgaaaa ccacacagtg cgtgttccct cagaacgtgt tccagaaggg catctacctg        900

ctgagagtgc aggcctccga cggcaacaac accagctttt ggagcgaaga gatcaagttc        960

gataccgaga tccaggcctt cctgctgcct ccagtgttca acatcagatc cctgtccgac       1020

tccttccaca tctacatcgg cgctcctaag cagtccggca acacccctgt gatccaggac       1080

taccctctga tctacgagat catcttctgg gagaacacct ccaacgccga gcggaagatc       1140

atcgagaaga aaaccgacgt gaccgtgcct aacctgaagc ctctgaccgt gtactgcgtg       1200

aaggctaggg cccacaccat ggacgaaaag ctgaacaagt cctccgtgtt ctccgacgcc       1260

gtgtgcgaaa agaccaagcc aggcaacacc tctaaaatcg agggccggat ggaccccaag       1320

agctgcgaca agacccacac ctgtcccccc tgccctgccc ctgaactgct gggcggaccc       1380

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa       1440

gtgacctgcg tggtggtgga cgtgtcccac gaggaccctg aagtgaagtt caattggtac       1500

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc       1560

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag       1620

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgagaaaac catcagcaag       1680

gccaagggcc agccccgcga gccccgggtg tacacactgc cccccagccg ggacgagctg       1740

accaagaacc aggtgtccct gacctgcctg gtgaaaggct tctaccccag cgatatcgcc       1800

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg       1860

gtcagcgacg gctcattcac cctgtacagc aagctgaccg tggacaagag ccggtggcag       1920

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag       1980

aagtccctga gcctgagccc cggcaagtag                                        2010


<210>    26
<211>    669
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker-FC RVT


<400>    26
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Lys Asn Leu Lys Ser Pro Gln Lys Val
             20                  25                  30 

Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg Trp Asn Arg Ser
         35                  40                  45 

Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp Tyr Gln Lys Thr
     50                  55                  60 

Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln Asn Ile Thr Ser
 65                  70                  75                  80 

Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val Tyr Glu Glu Ile
                 85                  90                  95 

Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser Ser Trp Tyr Glu
            100                 105                 110 

Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile Gly Pro Pro Glu
        115                 120                 125 

Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile His Ile Ser Pro
    130                 135                 140 

Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly Leu Ser Phe Thr
145                 150                 155                 160 

Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val Glu Glu Arg Ile
                165                 170                 175 

Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu Ser Pro Glu Thr
            180                 185                 190 

Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr Ser Trp Lys Ile
        195                 200                 205 

Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr Val Glu Asn Glu
    210                 215                 220 

Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln Asn Gln Asn Tyr
225                 230                 235                 240 

Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr Phe Gln Val Gln
                245                 250                 255 

Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn His Leu Tyr Lys
            260                 265                 270 

Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr Thr Gln Cys Val
        275                 280                 285 

Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu Leu Arg Val Gln
    290                 295                 300 

Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu Glu Ile Lys Phe
305                 310                 315                 320 

Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val Phe Asn Ile Arg
                325                 330                 335 

Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala Pro Lys Gln Ser
            340                 345                 350 

Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile Tyr Glu Ile Ile
        355                 360                 365 

Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile Ile Glu Lys Lys
    370                 375                 380 

Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr Val Tyr Cys Val
385                 390                 395                 400 

Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn Lys Ser Ser Val
                405                 410                 415 

Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly Asn Thr Ser Lys
            420                 425                 430 

Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys
        435                 440                 445 

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
    450                 455                 460 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
465                 470                 475                 480 

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                485                 490                 495 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            500                 505                 510 

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        515                 520                 525 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    530                 535                 540 

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
545                 550                 555                 560 

Ala Lys Gly Gln Pro Arg Glu Pro Arg Val Tyr Thr Leu Pro Pro Ser
                565                 570                 575 

Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            580                 585                 590 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        595                 600                 605 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Val Ser Asp Gly
    610                 615                 620 

Ser Phe Thr Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
625                 630                 635                 640 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                645                 650                 655 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            660                 665                


<210>    27
<211>    1434
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker-FC WT


<400>    27
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca tctcctacga cagccctgac tacaccgacg agtcctgcac cttcaagatc        120

tccctgcgga acttccggtc catcctgtcc tgggagctga agaaccactc catcgtgccc        180

acacactaca ccctgctgta caccatcatg tccaagcctg aggacctgaa ggtggtcaag        240

aactgcgcca acaccaccag atctttctgc gacctgaccg atgagtggcg gtctacccac        300

gaggcttacg tgacagtgct ggaaggcttc tccggcaata ccacactgtt cagctgctcc        360

cacaacttct ggctggccat cgacatgtcc ttcgagcctc cagagttcga gatcgtgggc        420

ttcaccaacc acatcaacgt gatggtcaag ttccccagca tcgtggaaga ggaactccag        480

ttcgacctga gcctggtcat cgaggaacag tccgagggca tcgtgaagaa gcacaagccc        540

gagatcaagg gcaacatgtc cggcaacttc acctacatca tcgacaagct gatccccaac        600

accaactact gcgtgtccgt gtacctggaa cactccgatg agcaggccgt gatcaagtcc        660

cctctgaagt gtaccctgct gcctcctggc caagagtctg agtctgccga gtctgctaaa        720

atcgagggcc ggatggaccc caagagctgc gacaagaccc acacctgtcc cccctgccct        780

gcccctgaac tgctgggcgg acccagcgtg ttcctgttcc ccccaaagcc caaggacacc        840

ctgatgatca gccggacccc cgaagtgacc tgcgtggtgg tggacgtgtc ccacgaggac        900

cctgaagtga agttcaattg gtacgtggac ggcgtggaag tgcacaacgc caagaccaag        960

cccagagagg aacagtacaa cagcacctac cgggtggtgt ccgtgctgac cgtgctgcac       1020

caggactggc tgaacggcaa agagtacaag tgcaaggtgt ccaacaaggc cctgcctgcc       1080

cccatcgaga aaaccatcag caaggccaag ggccagcccc gcgagcccca ggtgtacaca       1140

ctgcccccca gccgggacga gctgaccaag aaccaggtgt ccctgacctg cctggtgaaa       1200

ggcttctacc ccagcgatat cgccgtggaa tgggagagca acggccagcc cgagaacaac       1260

tacaagacca ccccccctgt gctggacagc gacggctcat tcttcctgta cagcaagctg       1320

accgtggaca agagccggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag       1380

gccctgcaca accactacac ccagaagtcc ctgagcctga gccccggcaa gtga             1434


<210>    28
<211>    477
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker-FC WT


<400>    28
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Ile Ser Tyr Asp Ser Pro Asp Tyr Thr
             20                  25                  30 

Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe Arg Ser Ile
         35                  40                  45 

Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr His Tyr Thr
     50                  55                  60 

Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys Val Val Lys
 65                  70                  75                  80 

Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr Asp Glu Trp
                 85                  90                  95 

Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly Phe Ser Gly
            100                 105                 110 

Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu Ala Ile Asp
        115                 120                 125 

Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe Thr Asn His
    130                 135                 140 

Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu Glu Leu Gln
145                 150                 155                 160 

Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly Ile Val Lys
                165                 170                 175 

Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn Phe Thr Tyr
            180                 185                 190 

Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val Ser Val Tyr
        195                 200                 205 

Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro Leu Lys Cys
    210                 215                 220 

Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu Ser Ala Lys
225                 230                 235                 240 

Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys
                245                 250                 255 

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
            260                 265                 270 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
        275                 280                 285 

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
    290                 295                 300 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
305                 310                 315                 320 

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
                325                 330                 335 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
            340                 345                 350 

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
        355                 360                 365 

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
    370                 375                 380 

Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
385                 390                 395                 400 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
                405                 410                 415 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
            420                 425                 430 

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
        435                 440                 445 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
    450                 455                 460 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
465                 470                 475        


<210>    29
<211>    1434
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker-FC EW


<400>    29
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca tctcctacga cagccctgac tacaccgacg agtcctgcac cttcaagatc        120

tccctgcgga acttccggtc catcctgtcc tgggagctga agaaccactc catcgtgccc        180

acacactaca ccctgctgta caccatcatg tccaagcctg aggacctgaa ggtggtcaag        240

aactgcgcca acaccaccag atctttctgc gacctgaccg atgagtggcg gtctacccac        300

gaggcttacg tgacagtgct ggaaggcttc tccggcaata ccacactgtt cagctgctcc        360

cacaacttct ggctggccat cgacatgtcc ttcgagcctc cagagttcga gatcgtgggc        420

ttcaccaacc acatcaacgt gatggtcaag ttccccagca tcgtggaaga ggaactccag        480

ttcgacctga gcctggtcat cgaggaacag tccgagggca tcgtgaagaa gcacaagccc        540

gagatcaagg gcaacatgtc cggcaacttc acctacatca tcgacaagct gatccccaac        600

accaactact gcgtgtccgt gtacctggaa cactccgatg agcaggccgt gatcaagtcc        660

cctctgaagt gtaccctgct gcctcctggc caagagtctg agtctgccga gtctgctaaa        720

atcgagggcc ggatggaccc caagagctgc gacaagaccc acacctgtcc cccctgccct        780

gcccctgaac tgctgggcgg acccagcgtg ttcctgttcc ccccaaagcc caaggacacc        840

ctgatgatca gccggacccc cgaagtgacc tgcgtggtgg tggacgtgtc ccacgaggac        900

cctgaagtga agttcaattg gtacgtggac ggcgtggaag tgcacaacgc caagaccaag        960

cccagagagg aacagtacaa cagcacctac cgggtggtgt ccgtgctgac cgtgctgcac       1020

caggactggc tgaacggcaa agagtacaag tgcaaggtgt ccaacaaggc cctgcctgcc       1080

cccatcgaga aaaccatcag caaggccaag ggccagcccc gcgagcccca ggtgtacaca       1140

ctgcccccca gccgggacga gctgaccgag aaccaggtgt ccctgacctg cctggtgaaa       1200

ggcttctacc ccagcgatat cgccgtggaa tgggagagca acggccagcc cgagaacaac       1260

tacaagacca ccccccctgt gctggacagc gacggctcat tcttcctgta cagctggctg       1320

accgtggaca agagccggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag       1380

gccctgcaca accactacac ccagaagtcc ctgagcctga gccccggcaa gtag             1434


<210>    30
<211>    477
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker-FC EW


<400>    30
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Ile Ser Tyr Asp Ser Pro Asp Tyr Thr
             20                  25                  30 

Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe Arg Ser Ile
         35                  40                  45 

Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr His Tyr Thr
     50                  55                  60 

Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys Val Val Lys
 65                  70                  75                  80 

Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr Asp Glu Trp
                 85                  90                  95 

Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly Phe Ser Gly
            100                 105                 110 

Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu Ala Ile Asp
        115                 120                 125 

Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe Thr Asn His
    130                 135                 140 

Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu Glu Leu Gln
145                 150                 155                 160 

Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly Ile Val Lys
                165                 170                 175 

Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn Phe Thr Tyr
            180                 185                 190 

Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val Ser Val Tyr
        195                 200                 205 

Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro Leu Lys Cys
    210                 215                 220 

Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu Ser Ala Lys
225                 230                 235                 240 

Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys
                245                 250                 255 

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
            260                 265                 270 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
        275                 280                 285 

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
    290                 295                 300 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
305                 310                 315                 320 

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
                325                 330                 335 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
            340                 345                 350 

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
        355                 360                 365 

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
    370                 375                 380 

Arg Asp Glu Leu Thr Glu Asn Gln Val Ser Leu Thr Cys Leu Val Lys
385                 390                 395                 400 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
                405                 410                 415 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
            420                 425                 430 

Ser Phe Phe Leu Tyr Ser Trp Leu Thr Val Asp Lys Ser Arg Trp Gln
        435                 440                 445 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
    450                 455                 460 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
465                 470                 475        


<210>    31
<211>    1434
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker-FC RVT


<400>    31
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca tctcctacga cagccctgac tacaccgacg agtcctgcac cttcaagatc        120

tccctgcgga acttccggtc catcctgtcc tgggagctga agaaccactc catcgtgccc        180

acacactaca ccctgctgta caccatcatg tccaagcctg aggacctgaa ggtggtcaag        240

aactgcgcca acaccaccag atctttctgc gacctgaccg atgagtggcg gtctacccac        300

gaggcttacg tgacagtgct ggaaggcttc tccggcaata ccacactgtt cagctgctcc        360

cacaacttct ggctggccat cgacatgtcc ttcgagcctc cagagttcga gatcgtgggc        420

ttcaccaacc acatcaacgt gatggtcaag ttccccagca tcgtggaaga ggaactccag        480

ttcgacctga gcctggtcat cgaggaacag tccgagggca tcgtgaagaa gcacaagccc        540

gagatcaagg gcaacatgtc cggcaacttc acctacatca tcgacaagct gatccccaac        600

accaactact gcgtgtccgt gtacctggaa cactccgatg agcaggccgt gatcaagtcc        660

cctctgaagt gtaccctgct gcctcctggc caagagtctg agtctgccga gtctgctaaa        720

atcgagggcc ggatggaccc caagagctgc gacaagaccc acacctgtcc cccctgccct        780

gcccctgaac tgctgggcgg acccagcgtg ttcctgttcc ccccaaagcc caaggacacc        840

ctgatgatca gccggacccc cgaagtgacc tgcgtggtgg tggacgtgtc ccacgaggac        900

cctgaagtga agttcaattg gtacgtggac ggcgtggaag tgcacaacgc caagaccaag        960

cccagagagg aacagtacaa cagcacctac cgggtggtgt ccgtgctgac cgtgctgcac       1020

caggactggc tgaacggcaa agagtacaag tgcaaggtgt ccaacaaggc cctgcctgcc       1080

cccatcgaga aaaccatcag caaggccaag ggccagcccc gcgagccccg ggtgtacaca       1140

ctgcccccca gccgggacga gctgaccaag aaccaggtgt ccctgacctg cctggtgaaa       1200

ggcttctacc ccagcgatat cgccgtggaa tgggagagca acggccagcc cgagaacaac       1260

tacaagacca ccccccctgt gctggtcagc gacggctcat tcaccctgta cagcaagctg       1320

accgtggaca agagccggtg gcagcagggc aacgtgttca gctgcagcgt gatgcacgag       1380

gccctgcaca accactacac ccagaagtcc ctgagcctga gccccggcaa gtag             1434


<210>    32
<211>    477
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker-FC RVT


<400>    32
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Ile Ser Tyr Asp Ser Pro Asp Tyr Thr
             20                  25                  30 

Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe Arg Ser Ile
         35                  40                  45 

Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr His Tyr Thr
     50                  55                  60 

Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys Val Val Lys
 65                  70                  75                  80 

Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr Asp Glu Trp
                 85                  90                  95 

Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly Phe Ser Gly
            100                 105                 110 

Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu Ala Ile Asp
        115                 120                 125 

Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe Thr Asn His
    130                 135                 140 

Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu Glu Leu Gln
145                 150                 155                 160 

Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly Ile Val Lys
                165                 170                 175 

Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn Phe Thr Tyr
            180                 185                 190 

Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val Ser Val Tyr
        195                 200                 205 

Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro Leu Lys Cys
    210                 215                 220 

Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu Ser Ala Lys
225                 230                 235                 240 

Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys
                245                 250                 255 

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
            260                 265                 270 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
        275                 280                 285 

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
    290                 295                 300 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
305                 310                 315                 320 

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
                325                 330                 335 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
            340                 345                 350 

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
        355                 360                 365 

Ala Lys Gly Gln Pro Arg Glu Pro Arg Val Tyr Thr Leu Pro Pro Ser
    370                 375                 380 

Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
385                 390                 395                 400 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
                405                 410                 415 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Val Ser Asp Gly
            420                 425                 430 

Ser Phe Thr Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
        435                 440                 445 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
    450                 455                 460 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
465                 470                 475        


<210>    33
<211>    45
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Linker_4GS*3


<400>    33
ggcggcggag gatctggcgg aggtggaagc ggaggcggtg gatct                         45


<210>    34
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_4GS*3


<400>    34
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
  1               5                  10                  15


<210>    35
<211>    810
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Linker_4GS*3-FC WT


<400>    35
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggccg gcggcggagg atctggcgga ggtggaagcg gaggcggtgg atctcccaag        120

agctgcgaca agacccacac ctgtcccccc tgccctgccc ctgaactgct gggcggaccc        180

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa        240

gtgacctgcg tggtggtgga cgtgtcccac gaggaccctg aagtgaagtt caattggtac        300

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc        360

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag        420

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgagaaaac catcagcaag        480

gccaagggcc agccccgcga gccccaggtg tacacactgc cccccagccg ggacgagctg        540

accaagaacc aggtgtccct gacctgcctg gtgaaaggct tctaccccag cgatatcgcc        600

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg        660

gacagcgacg gctcattctt cctgtacagc aagctgaccg tggacaagag ccggtggcag        720

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag        780

aagtccctga gcctgagccc cggcaagtga                                         810


<210>    36
<211>    269
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_4GS*3-FC WT


<400>    36
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
             20                  25                  30 

Ser Gly Gly Gly Gly Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys
         35                  40                  45 

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
     50                  55                  60 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
 65                  70                  75                  80 

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                 85                  90                  95 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            100                 105                 110 

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        115                 120                 125 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    130                 135                 140 

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
145                 150                 155                 160 

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                165                 170                 175 

Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            180                 185                 190 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        195                 200                 205 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    210                 215                 220 

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
225                 230                 235                 240 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                245                 250                 255 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            260                 265                


<210>    37
<211>    810
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Linker_4GS*3-FC EW


<400>    37
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggccg gcggcggagg atctggcgga ggtggaagcg gaggcggtgg atctcccaag        120

agctgcgaca agacccacac ctgtcccccc tgccctgccc ctgaactgct gggcggaccc        180

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa        240

gtgacctgcg tggtggtgga cgtgtcccac gaggaccctg aagtgaagtt caattggtac        300

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc        360

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag        420

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgagaaaac catcagcaag        480

gccaagggcc agccccgcga gccccaggtg tacacactgc cccccagccg ggacgagctg        540

accgagaacc aggtgtccct gacctgcctg gtgaaaggct tctaccccag cgatatcgcc        600

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg        660

gacagcgacg gctcattctt cctgtacagc tggctgaccg tggacaagag ccggtggcag        720

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag        780

aagtccctga gcctgagccc cggcaagtag                                         810


<210>    38
<211>    269
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_4GS*3-FC EW


<400>    38
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
             20                  25                  30 

Ser Gly Gly Gly Gly Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys
         35                  40                  45 

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
     50                  55                  60 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
 65                  70                  75                  80 

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                 85                  90                  95 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            100                 105                 110 

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        115                 120                 125 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    130                 135                 140 

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
145                 150                 155                 160 

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
                165                 170                 175 

Arg Asp Glu Leu Thr Glu Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            180                 185                 190 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        195                 200                 205 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
    210                 215                 220 

Ser Phe Phe Leu Tyr Ser Trp Leu Thr Val Asp Lys Ser Arg Trp Gln
225                 230                 235                 240 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                245                 250                 255 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            260                 265                


<210>    39
<211>    810
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Linker_4GS*3-FC RVT


<400>    39
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggccg gcggcggagg atctggcgga ggtggaagcg gaggcggtgg atctcccaag        120

agctgcgaca agacccacac ctgtcccccc tgccctgccc ctgaactgct gggcggaccc        180

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa        240

gtgacctgcg tggtggtgga cgtgtcccac gaggaccctg aagtgaagtt caattggtac        300

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc        360

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag        420

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgagaaaac catcagcaag        480

gccaagggcc agccccgcga gccccgggtg tacacactgc cccccagccg ggacgagctg        540

accaagaacc aggtgtccct gacctgcctg gtgaaaggct tctaccccag cgatatcgcc        600

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg        660

gtcagcgacg gctcattcac cctgtacagc aagctgaccg tggacaagag ccggtggcag        720

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag        780

aagtccctga gcctgagccc cggcaagtag                                         810


<210>    40
<211>    269
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_4GS*3-FC RVT


<400>    40
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
             20                  25                  30 

Ser Gly Gly Gly Gly Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys
         35                  40                  45 

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
     50                  55                  60 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
 65                  70                  75                  80 

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                 85                  90                  95 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
            100                 105                 110 

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
        115                 120                 125 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
    130                 135                 140 

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
145                 150                 155                 160 

Ala Lys Gly Gln Pro Arg Glu Pro Arg Val Tyr Thr Leu Pro Pro Ser
                165                 170                 175 

Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
            180                 185                 190 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
        195                 200                 205 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Val Ser Asp Gly
    210                 215                 220 

Ser Phe Thr Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
225                 230                 235                 240 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
                245                 250                 255 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            260                 265                


<210>    41
<211>    2037
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker_4GS*3-FC WT


<400>    41
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca agaacctgaa gtcccctcag aaagtggaag tggacatcat cgacgacaac        120

ttcatcctgc ggtggaacag atccgacgag tccgtgggca acgtgacctt cagcttcgac        180

taccagaaaa ccggcatgga caactggatc aagctgtccg gctgccagaa catcacctct        240

accaagtgca acttctccag cctgaagctg aacgtgtacg aggaaatcaa gctgcggatc        300

cgggccgaga aagagaacac cagcagttgg tacgaggtgg acagcttcac ccctttcaga        360

aaggcccaga tcggccctcc tgaagtgcac ctggaagccg aggataaggc catcgtgatc        420

cacatcagcc ccggcaccaa ggactctgtg atgtgggctc tcgacggcct gtccttcacc        480

tacagcctgg tcatctggaa gaactcctcc ggcgtggaag agagaatcga gaacatctac        540

tcccggcaca agatctacaa gctgagcccc gagacaacct actgcctgaa agtgaaggcc        600

gctctgctga cctcctggaa gatcggcgtg tactctcccg tgcactgcat caagaccacc        660

gtggaaaacg agctgcctcc tccagagaac atcgaggtgt ccgtgcagaa ccagaactac        720

gtgctgaagt gggactacac ctacgccaac atgacctttc aggtgcagtg gctgcacgct        780

tttctgaagc ggaaccctgg caaccacctg tacaagtgga agcagattcc cgactgcgag        840

aacgtgaaaa ccacacagtg cgtgttccct cagaacgtgt tccagaaggg catctacctg        900

ctgagagtgc aggcctccga cggcaacaac accagctttt ggagcgaaga gatcaagttc        960

gataccgaga tccaggcctt cctgctgcct ccagtgttca acatcagatc cctgtccgac       1020

tccttccaca tctacatcgg cgctcctaag cagtccggca acacccctgt gatccaggac       1080

taccctctga tctacgagat catcttctgg gagaacacct ccaacgccga gcggaagatc       1140

atcgagaaga aaaccgacgt gaccgtgcct aacctgaagc ctctgaccgt gtactgcgtg       1200

aaggctaggg cccacaccat ggacgaaaag ctgaacaagt cctccgtgtt ctccgacgcc       1260

gtgtgcgaaa agaccaagcc aggcaacacc tctaaaggcg gcggaggatc tggcggaggt       1320

ggaagcggag gcggtggatc tcccaagagc tgcgacaaga cccacacctg tcccccctgc       1380

cctgcccctg aactgctggg cggacccagc gtgttcctgt tccccccaaa gcccaaggac       1440

accctgatga tcagccggac ccccgaagtg acctgcgtgg tggtggacgt gtcccacgag       1500

gaccctgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc       1560

aagcccagag aggaacagta caacagcacc taccgggtgg tgtccgtgct gaccgtgctg       1620

caccaggact ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct       1680

gcccccatcg agaaaaccat cagcaaggcc aagggccagc cccgcgagcc ccaggtgtac       1740

acactgcccc ccagccggga cgagctgacc aagaaccagg tgtccctgac ctgcctggtg       1800

aaaggcttct accccagcga tatcgccgtg gaatgggaga gcaacggcca gcccgagaac       1860

aactacaaga ccaccccccc tgtgctggac agcgacggct cattcttcct gtacagcaag       1920

ctgaccgtgg acaagagccg gtggcagcag ggcaacgtgt tcagctgcag cgtgatgcac       1980

gaggccctgc acaaccacta cacccagaag tccctgagcc tgagccccgg caagtga          2037


<210>    42
<211>    678
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker_4GS*3-FC WT


<400>    42
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Lys Asn Leu Lys Ser Pro Gln Lys Val
             20                  25                  30 

Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg Trp Asn Arg Ser
         35                  40                  45 

Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp Tyr Gln Lys Thr
     50                  55                  60 

Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln Asn Ile Thr Ser
 65                  70                  75                  80 

Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val Tyr Glu Glu Ile
                 85                  90                  95 

Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser Ser Trp Tyr Glu
            100                 105                 110 

Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile Gly Pro Pro Glu
        115                 120                 125 

Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile His Ile Ser Pro
    130                 135                 140 

Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly Leu Ser Phe Thr
145                 150                 155                 160 

Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val Glu Glu Arg Ile
                165                 170                 175 

Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu Ser Pro Glu Thr
            180                 185                 190 

Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr Ser Trp Lys Ile
        195                 200                 205 

Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr Val Glu Asn Glu
    210                 215                 220 

Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln Asn Gln Asn Tyr
225                 230                 235                 240 

Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr Phe Gln Val Gln
                245                 250                 255 

Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn His Leu Tyr Lys
            260                 265                 270 

Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr Thr Gln Cys Val
        275                 280                 285 

Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu Leu Arg Val Gln
    290                 295                 300 

Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu Glu Ile Lys Phe
305                 310                 315                 320 

Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val Phe Asn Ile Arg
                325                 330                 335 

Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala Pro Lys Gln Ser
            340                 345                 350 

Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile Tyr Glu Ile Ile
        355                 360                 365 

Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile Ile Glu Lys Lys
    370                 375                 380 

Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr Val Tyr Cys Val
385                 390                 395                 400 

Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn Lys Ser Ser Val
                405                 410                 415 

Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly Asn Thr Ser Lys
            420                 425                 430 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro
        435                 440                 445 

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
    450                 455                 460 

Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
465                 470                 475                 480 

Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                485                 490                 495 

Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            500                 505                 510 

Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        515                 520                 525 

Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    530                 535                 540 

Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
545                 550                 555                 560 

Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                565                 570                 575 

Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            580                 585                 590 

Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        595                 600                 605 

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    610                 615                 620 

Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
625                 630                 635                 640 

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                645                 650                 655 

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            660                 665                 670 

Ser Leu Ser Pro Gly Lys
        675            


<210>    43
<211>    2037
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker_4GS*3-FC EW


<400>    43
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca agaacctgaa gtcccctcag aaagtggaag tggacatcat cgacgacaac        120

ttcatcctgc ggtggaacag atccgacgag tccgtgggca acgtgacctt cagcttcgac        180

taccagaaaa ccggcatgga caactggatc aagctgtccg gctgccagaa catcacctct        240

accaagtgca acttctccag cctgaagctg aacgtgtacg aggaaatcaa gctgcggatc        300

cgggccgaga aagagaacac cagcagttgg tacgaggtgg acagcttcac ccctttcaga        360

aaggcccaga tcggccctcc tgaagtgcac ctggaagccg aggataaggc catcgtgatc        420

cacatcagcc ccggcaccaa ggactctgtg atgtgggctc tcgacggcct gtccttcacc        480

tacagcctgg tcatctggaa gaactcctcc ggcgtggaag agagaatcga gaacatctac        540

tcccggcaca agatctacaa gctgagcccc gagacaacct actgcctgaa agtgaaggcc        600

gctctgctga cctcctggaa gatcggcgtg tactctcccg tgcactgcat caagaccacc        660

gtggaaaacg agctgcctcc tccagagaac atcgaggtgt ccgtgcagaa ccagaactac        720

gtgctgaagt gggactacac ctacgccaac atgacctttc aggtgcagtg gctgcacgct        780

tttctgaagc ggaaccctgg caaccacctg tacaagtgga agcagattcc cgactgcgag        840

aacgtgaaaa ccacacagtg cgtgttccct cagaacgtgt tccagaaggg catctacctg        900

ctgagagtgc aggcctccga cggcaacaac accagctttt ggagcgaaga gatcaagttc        960

gataccgaga tccaggcctt cctgctgcct ccagtgttca acatcagatc cctgtccgac       1020

tccttccaca tctacatcgg cgctcctaag cagtccggca acacccctgt gatccaggac       1080

taccctctga tctacgagat catcttctgg gagaacacct ccaacgccga gcggaagatc       1140

atcgagaaga aaaccgacgt gaccgtgcct aacctgaagc ctctgaccgt gtactgcgtg       1200

aaggctaggg cccacaccat ggacgaaaag ctgaacaagt cctccgtgtt ctccgacgcc       1260

gtgtgcgaaa agaccaagcc aggcaacacc tctaaaggcg gcggaggatc tggcggaggt       1320

ggaagcggag gcggtggatc tcccaagagc tgcgacaaga cccacacctg tcccccctgc       1380

cctgcccctg aactgctggg cggacccagc gtgttcctgt tccccccaaa gcccaaggac       1440

accctgatga tcagccggac ccccgaagtg acctgcgtgg tggtggacgt gtcccacgag       1500

gaccctgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc       1560

aagcccagag aggaacagta caacagcacc taccgggtgg tgtccgtgct gaccgtgctg       1620

caccaggact ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct       1680

gcccccatcg agaaaaccat cagcaaggcc aagggccagc cccgcgagcc ccaggtgtac       1740

acactgcccc ccagccggga cgagctgacc gagaaccagg tgtccctgac ctgcctggtg       1800

aaaggcttct accccagcga tatcgccgtg gaatgggaga gcaacggcca gcccgagaac       1860

aactacaaga ccaccccccc tgtgctggac agcgacggct cattcttcct gtacagctgg       1920

ctgaccgtgg acaagagccg gtggcagcag ggcaacgtgt tcagctgcag cgtgatgcac       1980

gaggccctgc acaaccacta cacccagaag tccctgagcc tgagccccgg caagtag          2037


<210>    44
<211>    678
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker_4GS*3-FC EW


<400>    44
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Lys Asn Leu Lys Ser Pro Gln Lys Val
             20                  25                  30 

Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg Trp Asn Arg Ser
         35                  40                  45 

Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp Tyr Gln Lys Thr
     50                  55                  60 

Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln Asn Ile Thr Ser
 65                  70                  75                  80 

Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val Tyr Glu Glu Ile
                 85                  90                  95 

Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser Ser Trp Tyr Glu
            100                 105                 110 

Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile Gly Pro Pro Glu
        115                 120                 125 

Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile His Ile Ser Pro
    130                 135                 140 

Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly Leu Ser Phe Thr
145                 150                 155                 160 

Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val Glu Glu Arg Ile
                165                 170                 175 

Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu Ser Pro Glu Thr
            180                 185                 190 

Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr Ser Trp Lys Ile
        195                 200                 205 

Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr Val Glu Asn Glu
    210                 215                 220 

Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln Asn Gln Asn Tyr
225                 230                 235                 240 

Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr Phe Gln Val Gln
                245                 250                 255 

Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn His Leu Tyr Lys
            260                 265                 270 

Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr Thr Gln Cys Val
        275                 280                 285 

Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu Leu Arg Val Gln
    290                 295                 300 

Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu Glu Ile Lys Phe
305                 310                 315                 320 

Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val Phe Asn Ile Arg
                325                 330                 335 

Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala Pro Lys Gln Ser
            340                 345                 350 

Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile Tyr Glu Ile Ile
        355                 360                 365 

Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile Ile Glu Lys Lys
    370                 375                 380 

Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr Val Tyr Cys Val
385                 390                 395                 400 

Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn Lys Ser Ser Val
                405                 410                 415 

Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly Asn Thr Ser Lys
            420                 425                 430 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro
        435                 440                 445 

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
    450                 455                 460 

Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
465                 470                 475                 480 

Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                485                 490                 495 

Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            500                 505                 510 

Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        515                 520                 525 

Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    530                 535                 540 

Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
545                 550                 555                 560 

Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                565                 570                 575 

Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Glu Asn
            580                 585                 590 

Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        595                 600                 605 

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    610                 615                 620 

Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Trp
625                 630                 635                 640 

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                645                 650                 655 

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            660                 665                 670 

Ser Leu Ser Pro Gly Lys
        675            


<210>    45
<211>    2037
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker_4GS*3-FC RVT


<400>    45
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca agaacctgaa gtcccctcag aaagtggaag tggacatcat cgacgacaac        120

ttcatcctgc ggtggaacag atccgacgag tccgtgggca acgtgacctt cagcttcgac        180

taccagaaaa ccggcatgga caactggatc aagctgtccg gctgccagaa catcacctct        240

accaagtgca acttctccag cctgaagctg aacgtgtacg aggaaatcaa gctgcggatc        300

cgggccgaga aagagaacac cagcagttgg tacgaggtgg acagcttcac ccctttcaga        360

aaggcccaga tcggccctcc tgaagtgcac ctggaagccg aggataaggc catcgtgatc        420

cacatcagcc ccggcaccaa ggactctgtg atgtgggctc tcgacggcct gtccttcacc        480

tacagcctgg tcatctggaa gaactcctcc ggcgtggaag agagaatcga gaacatctac        540

tcccggcaca agatctacaa gctgagcccc gagacaacct actgcctgaa agtgaaggcc        600

gctctgctga cctcctggaa gatcggcgtg tactctcccg tgcactgcat caagaccacc        660

gtggaaaacg agctgcctcc tccagagaac atcgaggtgt ccgtgcagaa ccagaactac        720

gtgctgaagt gggactacac ctacgccaac atgacctttc aggtgcagtg gctgcacgct        780

tttctgaagc ggaaccctgg caaccacctg tacaagtgga agcagattcc cgactgcgag        840

aacgtgaaaa ccacacagtg cgtgttccct cagaacgtgt tccagaaggg catctacctg        900

ctgagagtgc aggcctccga cggcaacaac accagctttt ggagcgaaga gatcaagttc        960

gataccgaga tccaggcctt cctgctgcct ccagtgttca acatcagatc cctgtccgac       1020

tccttccaca tctacatcgg cgctcctaag cagtccggca acacccctgt gatccaggac       1080

taccctctga tctacgagat catcttctgg gagaacacct ccaacgccga gcggaagatc       1140

atcgagaaga aaaccgacgt gaccgtgcct aacctgaagc ctctgaccgt gtactgcgtg       1200

aaggctaggg cccacaccat ggacgaaaag ctgaacaagt cctccgtgtt ctccgacgcc       1260

gtgtgcgaaa agaccaagcc aggcaacacc tctaaaggcg gcggaggatc tggcggaggt       1320

ggaagcggag gcggtggatc tcccaagagc tgcgacaaga cccacacctg tcccccctgc       1380

cctgcccctg aactgctggg cggacccagc gtgttcctgt tccccccaaa gcccaaggac       1440

accctgatga tcagccggac ccccgaagtg acctgcgtgg tggtggacgt gtcccacgag       1500

gaccctgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc       1560

aagcccagag aggaacagta caacagcacc taccgggtgg tgtccgtgct gaccgtgctg       1620

caccaggact ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct       1680

gcccccatcg agaaaaccat cagcaaggcc aagggccagc cccgcgagcc ccgggtgtac       1740

acactgcccc ccagccggga cgagctgacc aagaaccagg tgtccctgac ctgcctggtg       1800

aaaggcttct accccagcga tatcgccgtg gaatgggaga gcaacggcca gcccgagaac       1860

aactacaaga ccaccccccc tgtgctggtc agcgacggct cattcaccct gtacagcaag       1920

ctgaccgtgg acaagagccg gtggcagcag ggcaacgtgt tcagctgcag cgtgatgcac       1980

gaggccctgc acaaccacta cacccagaag tccctgagcc tgagccccgg caagtag          2037


<210>    46
<211>    678
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR1-Linker_4GS*3-FC RVT


<400>    46
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Lys Asn Leu Lys Ser Pro Gln Lys Val
             20                  25                  30 

Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg Trp Asn Arg Ser
         35                  40                  45 

Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp Tyr Gln Lys Thr
     50                  55                  60 

Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln Asn Ile Thr Ser
 65                  70                  75                  80 

Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val Tyr Glu Glu Ile
                 85                  90                  95 

Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser Ser Trp Tyr Glu
            100                 105                 110 

Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile Gly Pro Pro Glu
        115                 120                 125 

Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile His Ile Ser Pro
    130                 135                 140 

Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly Leu Ser Phe Thr
145                 150                 155                 160 

Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val Glu Glu Arg Ile
                165                 170                 175 

Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu Ser Pro Glu Thr
            180                 185                 190 

Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr Ser Trp Lys Ile
        195                 200                 205 

Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr Val Glu Asn Glu
    210                 215                 220 

Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln Asn Gln Asn Tyr
225                 230                 235                 240 

Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr Phe Gln Val Gln
                245                 250                 255 

Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn His Leu Tyr Lys
            260                 265                 270 

Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr Thr Gln Cys Val
        275                 280                 285 

Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu Leu Arg Val Gln
    290                 295                 300 

Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu Glu Ile Lys Phe
305                 310                 315                 320 

Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val Phe Asn Ile Arg
                325                 330                 335 

Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala Pro Lys Gln Ser
            340                 345                 350 

Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile Tyr Glu Ile Ile
        355                 360                 365 

Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile Ile Glu Lys Lys
    370                 375                 380 

Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr Val Tyr Cys Val
385                 390                 395                 400 

Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn Lys Ser Ser Val
                405                 410                 415 

Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly Asn Thr Ser Lys
            420                 425                 430 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro
        435                 440                 445 

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
    450                 455                 460 

Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
465                 470                 475                 480 

Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                485                 490                 495 

Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
            500                 505                 510 

Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
        515                 520                 525 

Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    530                 535                 540 

Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
545                 550                 555                 560 

Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                565                 570                 575 

Pro Arg Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
            580                 585                 590 

Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        595                 600                 605 

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    610                 615                 620 

Thr Pro Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu Tyr Ser Lys
625                 630                 635                 640 

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                645                 650                 655 

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            660                 665                 670 

Ser Leu Ser Pro Gly Lys
        675            


<210>    47
<211>    1461
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker_4GS*3-FC WT


<400>    47
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca tctcctacga cagccctgac tacaccgacg agtcctgcac cttcaagatc        120

tccctgcgga acttccggtc catcctgtcc tgggagctga agaaccactc catcgtgccc        180

acacactaca ccctgctgta caccatcatg tccaagcctg aggacctgaa ggtggtcaag        240

aactgcgcca acaccaccag atctttctgc gacctgaccg atgagtggcg gtctacccac        300

gaggcttacg tgacagtgct ggaaggcttc tccggcaata ccacactgtt cagctgctcc        360

cacaacttct ggctggccat cgacatgtcc ttcgagcctc cagagttcga gatcgtgggc        420

ttcaccaacc acatcaacgt gatggtcaag ttccccagca tcgtggaaga ggaactccag        480

ttcgacctga gcctggtcat cgaggaacag tccgagggca tcgtgaagaa gcacaagccc        540

gagatcaagg gcaacatgtc cggcaacttc acctacatca tcgacaagct gatccccaac        600

accaactact gcgtgtccgt gtacctggaa cactccgatg agcaggccgt gatcaagtcc        660

cctctgaagt gtaccctgct gcctcctggc caagagtctg agtctgccga gtctgctaaa        720

ggcggcggag gatctggcgg aggtggaagc ggaggcggtg gatctcccaa gagctgcgac        780

aagacccaca cctgtccccc ctgccctgcc cctgaactgc tgggcggacc cagcgtgttc        840

ctgttccccc caaagcccaa ggacaccctg atgatcagcc ggacccccga agtgacctgc        900

gtggtggtgg acgtgtccca cgaggaccct gaagtgaagt tcaattggta cgtggacggc        960

gtggaagtgc acaacgccaa gaccaagccc agagaggaac agtacaacag cacctaccgg       1020

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc       1080

aaggtgtcca acaaggccct gcctgccccc atcgagaaaa ccatcagcaa ggccaagggc       1140

cagccccgcg agccccaggt gtacacactg ccccccagcc gggacgagct gaccaagaac       1200

caggtgtccc tgacctgcct ggtgaaaggc ttctacccca gcgatatcgc cgtggaatgg       1260

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgac       1320

ggctcattct tcctgtacag caagctgacc gtggacaaga gccggtggca gcagggcaac       1380

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg       1440

agcctgagcc ccggcaagtg a                                                 1461


<210>    48
<211>    486
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker_4GS*3-FC WT


<400>    48
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Ile Ser Tyr Asp Ser Pro Asp Tyr Thr
             20                  25                  30 

Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe Arg Ser Ile
         35                  40                  45 

Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr His Tyr Thr
     50                  55                  60 

Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys Val Val Lys
 65                  70                  75                  80 

Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr Asp Glu Trp
                 85                  90                  95 

Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly Phe Ser Gly
            100                 105                 110 

Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu Ala Ile Asp
        115                 120                 125 

Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe Thr Asn His
    130                 135                 140 

Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu Glu Leu Gln
145                 150                 155                 160 

Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly Ile Val Lys
                165                 170                 175 

Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn Phe Thr Tyr
            180                 185                 190 

Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val Ser Val Tyr
        195                 200                 205 

Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro Leu Lys Cys
    210                 215                 220 

Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu Ser Ala Lys
225                 230                 235                 240 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro
                245                 250                 255 

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
            260                 265                 270 

Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        275                 280                 285 

Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    290                 295                 300 

Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
305                 310                 315                 320 

Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
                325                 330                 335 

Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
            340                 345                 350 

Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
        355                 360                 365 

Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
    370                 375                 380 

Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
385                 390                 395                 400 

Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                405                 410                 415 

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            420                 425                 430 

Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        435                 440                 445 

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    450                 455                 460 

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
465                 470                 475                 480 

Ser Leu Ser Pro Gly Lys
                485    


<210>    49
<211>    1461
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker_4GS*3-FC EW


<400>    49
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca tctcctacga cagccctgac tacaccgacg agtcctgcac cttcaagatc        120

tccctgcgga acttccggtc catcctgtcc tgggagctga agaaccactc catcgtgccc        180

acacactaca ccctgctgta caccatcatg tccaagcctg aggacctgaa ggtggtcaag        240

aactgcgcca acaccaccag atctttctgc gacctgaccg atgagtggcg gtctacccac        300

gaggcttacg tgacagtgct ggaaggcttc tccggcaata ccacactgtt cagctgctcc        360

cacaacttct ggctggccat cgacatgtcc ttcgagcctc cagagttcga gatcgtgggc        420

ttcaccaacc acatcaacgt gatggtcaag ttccccagca tcgtggaaga ggaactccag        480

ttcgacctga gcctggtcat cgaggaacag tccgagggca tcgtgaagaa gcacaagccc        540

gagatcaagg gcaacatgtc cggcaacttc acctacatca tcgacaagct gatccccaac        600

accaactact gcgtgtccgt gtacctggaa cactccgatg agcaggccgt gatcaagtcc        660

cctctgaagt gtaccctgct gcctcctggc caagagtctg agtctgccga gtctgctaaa        720

ggcggcggag gatctggcgg aggtggaagc ggaggcggtg gatctcccaa gagctgcgac        780

aagacccaca cctgtccccc ctgccctgcc cctgaactgc tgggcggacc cagcgtgttc        840

ctgttccccc caaagcccaa ggacaccctg atgatcagcc ggacccccga agtgacctgc        900

gtggtggtgg acgtgtccca cgaggaccct gaagtgaagt tcaattggta cgtggacggc        960

gtggaagtgc acaacgccaa gaccaagccc agagaggaac agtacaacag cacctaccgg       1020

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc       1080

aaggtgtcca acaaggccct gcctgccccc atcgagaaaa ccatcagcaa ggccaagggc       1140

cagccccgcg agccccaggt gtacacactg ccccccagcc gggacgagct gaccgagaac       1200

caggtgtccc tgacctgcct ggtgaaaggc ttctacccca gcgatatcgc cgtggaatgg       1260

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgac       1320

ggctcattct tcctgtacag ctggctgacc gtggacaaga gccggtggca gcagggcaac       1380

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg       1440

agcctgagcc ccggcaagta g                                                 1461


<210>    50
<211>    486
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker_4GS*3-FC EW


<400>    50
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Ile Ser Tyr Asp Ser Pro Asp Tyr Thr
             20                  25                  30 

Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe Arg Ser Ile
         35                  40                  45 

Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr His Tyr Thr
     50                  55                  60 

Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys Val Val Lys
 65                  70                  75                  80 

Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr Asp Glu Trp
                 85                  90                  95 

Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly Phe Ser Gly
            100                 105                 110 

Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu Ala Ile Asp
        115                 120                 125 

Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe Thr Asn His
    130                 135                 140 

Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu Glu Leu Gln
145                 150                 155                 160 

Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly Ile Val Lys
                165                 170                 175 

Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn Phe Thr Tyr
            180                 185                 190 

Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val Ser Val Tyr
        195                 200                 205 

Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro Leu Lys Cys
    210                 215                 220 

Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu Ser Ala Lys
225                 230                 235                 240 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro
                245                 250                 255 

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
            260                 265                 270 

Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        275                 280                 285 

Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    290                 295                 300 

Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
305                 310                 315                 320 

Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
                325                 330                 335 

Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
            340                 345                 350 

Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
        355                 360                 365 

Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
    370                 375                 380 

Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Glu Asn
385                 390                 395                 400 

Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                405                 410                 415 

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            420                 425                 430 

Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Trp
        435                 440                 445 

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    450                 455                 460 

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
465                 470                 475                 480 

Ser Leu Ser Pro Gly Lys
                485    


<210>    51
<211>    1461
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker_4GS*3-FC RVT


<400>    51
gccaccatgt ggtggcgtct gtggtggctg ctgcttctgc tgttgctgct gtggcctatg         60

gtctgggcca tctcctacga cagccctgac tacaccgacg agtcctgcac cttcaagatc        120

tccctgcgga acttccggtc catcctgtcc tgggagctga agaaccactc catcgtgccc        180

acacactaca ccctgctgta caccatcatg tccaagcctg aggacctgaa ggtggtcaag        240

aactgcgcca acaccaccag atctttctgc gacctgaccg atgagtggcg gtctacccac        300

gaggcttacg tgacagtgct ggaaggcttc tccggcaata ccacactgtt cagctgctcc        360

cacaacttct ggctggccat cgacatgtcc ttcgagcctc cagagttcga gatcgtgggc        420

ttcaccaacc acatcaacgt gatggtcaag ttccccagca tcgtggaaga ggaactccag        480

ttcgacctga gcctggtcat cgaggaacag tccgagggca tcgtgaagaa gcacaagccc        540

gagatcaagg gcaacatgtc cggcaacttc acctacatca tcgacaagct gatccccaac        600

accaactact gcgtgtccgt gtacctggaa cactccgatg agcaggccgt gatcaagtcc        660

cctctgaagt gtaccctgct gcctcctggc caagagtctg agtctgccga gtctgctaaa        720

ggcggcggag gatctggcgg aggtggaagc ggaggcggtg gatctcccaa gagctgcgac        780

aagacccaca cctgtccccc ctgccctgcc cctgaactgc tgggcggacc cagcgtgttc        840

ctgttccccc caaagcccaa ggacaccctg atgatcagcc ggacccccga agtgacctgc        900

gtggtggtgg acgtgtccca cgaggaccct gaagtgaagt tcaattggta cgtggacggc        960

gtggaagtgc acaacgccaa gaccaagccc agagaggaac agtacaacag cacctaccgg       1020

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc       1080

aaggtgtcca acaaggccct gcctgccccc atcgagaaaa ccatcagcaa ggccaagggc       1140

cagccccgcg agccccgggt gtacacactg ccccccagcc gggacgagct gaccaagaac       1200

caggtgtccc tgacctgcct ggtgaaaggc ttctacccca gcgatatcgc cgtggaatgg       1260

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggtcagcgac       1320

ggctcattca ccctgtacag caagctgacc gtggacaaga gccggtggca gcagggcaac       1380

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg       1440

agcctgagcc ccggcaagta g                                                 1461


<210>    52
<211>    486
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    IFNAR2-Linker_4GS*3-FC RVT


<400>    52
Ala Thr Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu
  1               5                  10                  15 

Leu Trp Pro Met Val Trp Ala Ile Ser Tyr Asp Ser Pro Asp Tyr Thr
             20                  25                  30 

Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe Arg Ser Ile
         35                  40                  45 

Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr His Tyr Thr
     50                  55                  60 

Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys Val Val Lys
 65                  70                  75                  80 

Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr Asp Glu Trp
                 85                  90                  95 

Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly Phe Ser Gly
            100                 105                 110 

Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu Ala Ile Asp
        115                 120                 125 

Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe Thr Asn His
    130                 135                 140 

Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu Glu Leu Gln
145                 150                 155                 160 

Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly Ile Val Lys
                165                 170                 175 

Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn Phe Thr Tyr
            180                 185                 190 

Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val Ser Val Tyr
        195                 200                 205 

Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro Leu Lys Cys
    210                 215                 220 

Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu Ser Ala Lys
225                 230                 235                 240 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro
                245                 250                 255 

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
            260                 265                 270 

Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        275                 280                 285 

Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    290                 295                 300 

Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
305                 310                 315                 320 

Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
                325                 330                 335 

Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
            340                 345                 350 

Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
        355                 360                 365 

Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
    370                 375                 380 

Pro Arg Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn
385                 390                 395                 400 

Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                405                 410                 415 

Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            420                 425                 430 

Thr Pro Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu Tyr Ser Lys
        435                 440                 445 

Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    450                 455                 460 

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
465                 470                 475                 480 

Ser Leu Ser Pro Gly Lys
                485    


<210>    53
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_4GS


<400>    53
Gly Gly Gly Gly Ser
  1               5


<210>    54
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_4GS*2


<400>    54
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
  1               5                  10


<210>    55
<211>    20
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_4GS*4


<400>    55
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
  1               5                  10                  15 

Gly Gly Gly Ser
             20


<210>    56
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_6G


<400>    56
Gly Gly Gly Gly Gly Gly
  1               5    


<210>    57
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_8G


<400>    57
Gly Gly Gly Gly Gly Gly Gly Gly
  1               5            


<210>    58
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AEAAAKEAAAKA


<400>    58
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala
  1               5                  10        


<210>    59
<211>    46
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_EAAAK complex


<400>    59
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys
  1               5                  10                  15 

Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala
             20                  25                  30 

Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala
         35                  40                  45 




<210>    60
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_EAAAK*3


<400>    60
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys
  1               5                  10                  15


<210>    61
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_EAAAK


<400>    61
Glu Ala Ala Ala Lys
  1               5


<210>    62
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_EAAAK*2


<400>    62
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys
  1               5                  10


<210>    63
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*5


<400>    63
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10


<210>    64
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*6


<400>    64
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10        


<210>    65
<211>    14
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*7


<400>    65
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                


<210>    66
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*8


<400>    66
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                  15 




<210>    67
<211>    18
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*9


<400>    67
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                  15 

Ala Pro
       


<210>    68
<211>    20
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*10


<400>    68
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                  15 

Ala Pro Ala Pro
             20


<210>    69
<211>    22
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*11


<400>    69
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                  15 

Ala Pro Ala Pro Ala Pro
             20        


<210>    70
<211>    24
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*12


<400>    70
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                  15 

Ala Pro Ala Pro Ala Pro Ala Pro
             20                


<210>    71
<211>    26
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*13


<400>    71
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                  15 

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
             20                  25    


<210>    72
<211>    28
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*14


<400>    72
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                  15 

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
             20                  25            


<210>    73
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*15


<400>    73
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                  15 

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
             20                  25                  30


<210>    74
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*16


<400>    74
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                  15 

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
             20                  25                  30 




<210>    75
<211>    34
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_AP*17


<400>    75
Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
  1               5                  10                  15 

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro
             20                  25                  30 

Ala Pro
       


<210>    76
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Linker_PAPAP


<400>    76
Pro Ala Pro Ala Pro
  1               5
