                         SEQUENCE LISTING

<110>  Themis Bioscience GmbH
 
<120>  Norovirus vaccines

<130>  TM 5449-02WO

<150>  EP 18248201.8
<151>  2018-12-28

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  540
<212>  PRT
<213>  Norovirus

<400>  1

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Val Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Pro Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asp Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly Arg Val Gln Phe Glu 
        355                 360                 365             


Thr Asp Thr Asp Arg Asp Phe Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Gly Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Val 
    530                 535                 540 


<210>  2
<211>  268
<212>  PRT
<213>  Norovirus

<400>  2

Met Ala Gly Ala Phe Phe Ala Gly Leu Ala Ser Asp Val Leu Gly Ser 
1               5                   10                  15      


Gly Leu Gly Ser Leu Ile Asn Ala Gly Ala Gly Ala Ile Asn Gln Lys 
            20                  25                  30          


Val Glu Phe Glu Asn Asn Arg Lys Leu Gln Gln Ala Ser Phe Gln Phe 
        35                  40                  45              


Ser Ser Asn Leu Gln Gln Ala Ser Phe Gln His Asp Lys Glu Met Leu 
    50                  55                  60                  


Gln Ala Gln Ile Glu Ala Thr Lys Lys Leu Gln Gln Glu Met Met Lys 
65                  70                  75                  80  


Val Lys Gln Ala Met Leu Leu Glu Gly Gly Phe Phe Glu Thr Asp Ala 
                85                  90                  95      


Ala Arg Gly Ala Ile Asn Ala Pro Met Thr Lys Ala Leu Asp Trp Ser 
            100                 105                 110         


Gly Thr Arg Tyr Trp Ala Pro Asp Ala Arg Thr Thr Thr Tyr Asn Ala 
        115                 120                 125             


Gly Arg Phe Ser Thr Pro Gln Pro Ser Gly Ala Leu Pro Gly Arg Ala 
    130                 135                 140                 


Asn Leu Arg Asp Ala Val Pro Ala Arg Gly Ser Ser Ser Lys Ser Ser 
145                 150                 155                 160 


Asn Ser Ser Thr Ala Thr Ser Val Tyr Ser Asn Gln Thr Thr Ser Thr 
                165                 170                 175     


Arg Leu Gly Ser Thr Ala Val Ser Gly Thr Ser Val Ser Ser Phe Pro 
            180                 185                 190         


Ser Thr Ala Arg Thr Arg Ser Trp Val Glu Asp Gln Ser Arg Asn Leu 
        195                 200                 205             


Ser Pro Ser Met Arg Gly Ala His Asn Ile Ser Phe Val Thr Pro Pro 
    210                 215                 220                 


Ser Ser Arg Ser Ser Ser Gln Gly Thr Val Ser Thr Val Pro Lys Glu 
225                 230                 235                 240 


Val Leu Asp Ser Trp Thr Gly Ala Phe Asn Thr Arg Arg Gln Pro Leu 
                245                 250                 255     


Phe Ala His Ile Arg Lys Arg Gly Glu Ser Arg Ala 
            260                 265             


<210>  3
<211>  1623
<212>  DNA
<213>  Norovirus

<400>  3
atgaagatgg cgtcgagtga cgccaaccca tctgatgggt ccgcagccaa cctcgtccca       60

gaggtcaaca atgaggttat ggctctggag cccgttgttg gtgccgccat tgcggcacct      120

gtagcgggcc aacaaaatgt aattgacccc tggattagaa ataattttgt acaagcccct      180

ggtggagagt ttacagtatc ccctagaaac gctccaggtg aaatactatg gagcgcgccc      240

ttgggccctg atctaaatcc ctacctatcc catttggcca gaatgtacaa tggttatgca      300

ggtggttttg aagtgcaggt aattctcgcg gggaacgcgt tcaccgccgg gaaggtcata      360

tttgcagcag tcccaccaaa ttttccaact gaaggcttga gccccagcca ggtcactatg      420

ttcccccata tagtagtaga tgttaggcaa ctagaacctg tgttgattcc cttacccgat      480

gttaggaata atttctatca ttataatcaa tcaaatgacc ctaccattaa gttgatagca      540

atgttgtata caccacttag ggctaataat gctggggatg atgtcttcac agtttcttgc      600

cgagttctca cgagaccatc ccccgatttt gatttcatat ttttagtgcc acccacagtt      660

gagtcaagaa ctaaaccatt ctctgtccca gttttaactg ttgaggagat gaccaattca      720

agattcccca ttcctttgga aaagttgttc acgggtccca gcagtgcctt tgttgtccaa      780

ccacaaaacg gcaggtgcac gactgatggc gtgctcctag gcaccaccca actgtctcct      840

gtcaacatct gcaccttcag aggagatgtc acccacatca caggtagtcg taactacaca      900

atgaatttgg cttctcaaaa ttggaacgat tatgacccaa cagaagaaat cccagcccct      960

ctaggaactc cagattttgt ggggaagatt caaggcgttc tcacccaaac cacaaggaca     1020

gatggctcaa cacgcggcca caaagctaca gtgtacactg ggagcgccga ctttgctcca     1080

aaactgggta gagttcaatt tgaaactgac acagaccgtg attttgaagc taaccaaaac     1140

acaaagttca ccccagtcgg tgtcatccaa gatggtggca ccacccaccg aaatgaaccc     1200

caacagtggg tgctcccaag ctactcaggc agaaatactc ataatgtgca tctggccccc     1260

gctgtagccc ccacttttcc gggtgagcaa cttctcttct tcagatccac catgcccgga     1320

tgcagcgggt accccaacat ggatttggac tgtctgctcc cccaggaatg ggtgcagtac     1380

ttctaccaag aggcagcccc agcacaatct gatgtggctc tgctaagatt tgtgaatcca     1440

gacacaggta gggttttgtt tgagtgtaag cttcataaat caggctatgt tacagtggct     1500

cacactggcc aacatgattt ggttatcccc cccaatggtt attttaggtt tgattcctgg     1560

gtcaaccagt tttacacgct tgcccccatg ggaaatggaa cggggcgtag acgtgcagta     1620

taa                                                                   1623


<210>  4
<211>  804
<212>  DNA
<213>  Norovirus

<400>  4
atggctggag ctttctttgc tggattggca tctgatgtcc ttggctctgg gcttggttcc       60

cttatcaatg ctggggctgg ggccatcaac caaaaagttg agtttgaaaa taacagaaaa      120

ttgcaacaag catccttcca atttagcagc aatctacaac aggcttcctt tcaacatgac      180

aaagagatgc tccaagcaca aattgaggcc accaaaaagc tacaacagga aatgatgaaa      240

gttaagcagg caatgctcct agagggtggg ttctttgaga cagatgcagc ccgcggggca      300

atcaacgccc ccatgacaaa agctttggac tggagcggga caaggtactg ggctcccgat      360

gctaggacta caacatacaa tgcaggccgc ttttccaccc ctcaaccatc gggggcactg      420

ccaggaagag ctaatcttag ggatgctgtc cctgctcggg gttcctccag caaatcttct      480

aactcttcta ctgctacttc tgtgtactca aatcaaacta cttcaacgag acttggttct      540

acagctgttt ctggtaccag tgtctcgagc ttcccgtcaa ctgcaaggac taggagctgg      600

gttgaggatc aaagtaggaa tttgtcacct tccatgaggg gggcccacaa catatcgttt      660

gtcaccccac catctagcag atcctctagc caaggcacag tctcaaccgt gcctaaagag      720

gttttggact cctggactgg cgctttcaac acgcgcaggc agccactctt cgctcacatt      780

cgtaagcgag gggagtcacg ggcg                                             804


<210>  5
<211>  1623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized VP1

<400>  5
atgaagatgg cttcctctga cgccaatcct tccgatggaa gcgctgctaa tctggtgccc       60

gaggtcaaca acgaggtaat ggcactggaa cccgtcgtgg gtgcagcgat tgccgcccct      120

gttgctggac agcagaatgt gatcgatccc tggatacgca ataatttcgt gcaggcgcct      180

ggaggcgaat tcacggtgtc tcctagaaat gccccaggcg aaattctgtg gtcagctcct      240

ctggggcccg acttgaaccc atacctcagt catctcgcac gaatgtacaa cgggtatgcc      300

ggaggctttg aagtgcaggt gatccttgcc ggaaacgcat tcaccgccgg gaaagtcatc      360

ttcgccgctg tcccacccaa tttccctacc gaagggcttt caccaagtca ggtaaccatg      420

tttccacaca tcgttgtgga tgtccgccag cttgaacctg tactcatccc tctgccagat      480

gttaggaaca acttctacca ctacaaccag agcaacgatc caaccattaa gctgatcgcc      540

atgttgtata caccactcag agccaataac gcaggcgatg atgtgttcac tgtctcttgt      600

agagtcctga cacgaccctc tcccgatttc gacttcattt tcctcgtgcc acccaccgtt      660

gagagccgga caaaaccgtt tagcgtaccc gtgctgactg tcgaggagat gaccaattct      720

aggttcccca ttcctctgga gaagctgttt actggaccgt ccagcgcctt tgttgtgcag      780

ccacagaacg gccgctgtac tactgatggc gtgctgcttg gtacaaccca actgagccca      840

gtgaatatct gcaccttcag aggggacgtg actcatatca ccggatcccg caactacaca      900

atgaacctgg cttcacagaa ctggaatgac tacgatccaa cggaggaaat accggctcct      960

ctgggtactc cggacttcgt cggcaagatt cagggagtgc tgacccaaac tacccgtact     1020

gatgggagca cccgtggcca caaagctacc gtgtatacag gcagtgctga ctttgcgcct     1080

aaactgggta gggtgcaatt tgagactgac accgatcggg actttgaggc caatcagaat     1140

accaagttta cacccgtcgg cgtcatacag gacggcggga cgacacatcg caacgaaccc     1200

cagcaatggg tattgccctc ctattccggt agaaacacgc acaacgttca cttggcacca     1260

gccgtggccc ctacctttcc tggagagcaa ctgctgttct tccgatctac aatgccgggg     1320

tgtagtggct atccaaacat ggacctcgac tgcctcctgc cccaagagtg ggttcagtac     1380

ttttatcagg aagccgcacc cgcccagagc gacgttgcac tgttgcggtt tgtaaatccc     1440

gatacgggtc gggtgctctt cgagtgcaag ctgcataaat caggctatgt cacagtggca     1500

cacacagggc aacatgacct tgtgattccg cctaacggtt acttccggtt tgacagctgg     1560

gtgaatcagt tttacactct ggctcctatg ggaaatggga caggcaggag aagggcggtt     1620

tga                                                                   1623


<210>  6
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized VP2

<400>  6
atggcaggag ccttctttgc aggattggca agcgatgttc tgggctccgg acttggttcc       60

ctgatcaacg caggagctgg cgccatcaat cagaaggtcg aattcgagaa caatcggaag      120

ctgcagcaag cttcctttca gttctctagc aatctgcagc aagcctcatt tcagcatgac      180

aaagagatgc tgcaggctca gatagaggcc acgaagaaac tgcagcaaga gatgatgaaa      240

gtgaagcaag cgatgctcct tgaaggtggc ttctttgaga ctgacgctgc gagaggcgcc      300

attaatgccc cgatgacgaa agccctggac tggtcaggga ccaggtattg ggctcctgat      360

gcccgcacca ctacatacaa cgccggtcgc ttttccactc ctcaaccatc aggggcactc      420

ccaggacggg cgaatctgag ggatgctgtg cccgcaagag gcagcagctc caagagcagt      480

aacagctcaa ccgctacaag cgtgtacagc aaccagacga cctcaacccg gttgggctcc      540

acagccgtat ctggtacctc tgtgagctct ttcccctcta ctgcccgtac tcgaagttgg      600

gtggaagatc agtcccggaa tctctctccc agtatgcgtg gggctcacaa catcagcttc      660

gttaccccac cctctagtcg ctcaagtagc cagggcacag tgtccacagt ccctaaagaa      720

gtcctggact cctggacagg ggcctttaac accagaaggc agcctctctt cgcccacatt      780

aggaagagag gggagagtcg agca                                             804


<210>  7
<211>  2526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VP1-linker-VP2 construct

<400>  7
cgtacggcca ccatgaagat ggcgtcgagt gacgccaacc catctgatgg gtccgcagcc       60

aacctcgtcc cagaggtcaa caatgaggtt atggctctgg agcccgttgt tggtgccgcc      120

attgcggcac ctgtagcggg ccaacaaaat gtaattgacc cctggattag aaataatttt      180

gtacaagccc ctggtggaga gtttacagta tcccctagaa acgctccagg tgaaatacta      240

tggagcgcgc ccttgggccc tgatctaaat ccctacctat cccatttggc cagaatgtac      300

aatggttatg caggtggttt tgaagtgcag gtaattctcg cggggaacgc gttcaccgcc      360

gggaaggtca tatttgcagc agtcccacca aattttccaa ctgaaggctt gagccccagc      420

caggtcacta tgttccccca tatagtagta gatgttaggc aactagaacc tgtgttgatt      480

cccttacccg atgttaggaa taatttctat cattataatc aatcaaatga ccctaccatt      540

aagttgatag caatgttgta tacaccactt agggctaata atgctgggga tgatgtcttc      600

acagtttctt gccgagttct cacgagacca tcccccgatt ttgatttcat atttttagtg      660

ccacccacag ttgagtcaag aactaaacca ttctctgtcc cagttttaac tgttgaggag      720

atgaccaatt caagattccc cattcctttg gaaaagttgt tcacgggtcc cagcagtgcc      780

tttgttgtcc aaccacaaaa cggcaggtgc acgactgatg gcgtgctcct aggcaccacc      840

caactgtctc ctgtcaacat ctgcaccttc agaggagatg tcacccacat cacaggtagt      900

cgtaactaca caatgaattt ggcttctcaa aattggaacg attatgaccc aacagaagaa      960

atcccagccc ctctaggaac tccagatttt gtggggaaga ttcaaggcgt tctcacccaa     1020

accacaagga cagatggctc aacacgcggc cacaaagcta cagtgtacac tgggagcgcc     1080

gactttgctc caaaactggg tagagttcaa tttgaaactg acacagaccg tgattttgaa     1140

gctaaccaaa acacaaagtt caccccagtc ggtgtcatcc aagatggtgg caccacccac     1200

cgaaatgaac cccaacagtg ggtgctccca agctactcag gcagaaatac tcataatgtg     1260

catctggccc ccgctgtagc ccccactttt ccgggtgagc aacttctctt cttcagatcc     1320

accatgcccg gatgcagcgg gtaccccaac atggatttgg actgtctgct cccccaggaa     1380

tgggtgcagt acttctacca agaggcagcc ccagcacaat ctgatgtggc tctgctaaga     1440

tttgtgaatc cagacacagg tagggttttg tttgagtgta agcttcataa atcaggctat     1500

gttacagtgg ctcacactgg ccaacatgat ttggttatcc cccccaatgg ttattttagg     1560

tttgattcct gggtcaacca gttttacacg cttgccccca tgggaaatgg aacggggcgt     1620

agacgtgcag tataatagcc taccctccat cattgttata aaaaacttag gaaccaggtc     1680

cacacagccg ccagcccatc aacggccacc atggctggag ctttctttgc tggattggca     1740

tctgatgtcc ttggctctgg gcttggttcc cttatcaatg ctggggctgg ggccatcaac     1800

caaaaagttg agtttgaaaa taacagaaaa ttgcaacaag catccttcca atttagcagc     1860

aatctacaac aggcttcctt tcaacatgac aaagagatgc tccaagcaca aattgaggcc     1920

accaaaaagc tacaacagga aatgatgaaa gttaagcagg caatgctcct agagggtggg     1980

ttctttgaga cagatgcagc ccgcggggca atcaacgccc ccatgacaaa agctttggac     2040

tggagcggga caaggtactg ggctcccgat gctaggacta caacatacaa tgcaggccgc     2100

ttttccaccc ctcaaccatc gggggcactg ccaggaagag ctaatcttag ggatgctgtc     2160

cctgctcggg gttcctccag caaatcttct aactcttcta ctgctacttc tgtgtactca     2220

aatcaaacta cttcaacgag acttggttct acagctgttt ctggtaccag tgtctcgagc     2280

ttcccgtcaa ctgcaaggac taggagctgg gttgaggatc aaagtaggaa tttgtcacct     2340

tccatgaggg gggcccacaa catatcgttt gtcaccccac catctagcag atcctctagc     2400

caaggcacag tctcaaccgt gcctaaagag gttttggact cctggactgg cgctttcaac     2460

acgcgcaggc agccactctt cgctcacatt cgtaagcgag gggagtcacg ggcgtaatga     2520

gcgcgc                                                                2526


<210>  8
<211>  2526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VP1-linker-VP2 construct codon optimized

<400>  8
cgtacggcca ccatgaagat ggcttcctct gacgccaatc cttccgatgg aagcgctgct       60

aatctggtgc ccgaggtcaa caacgaggta atggcactgg aacccgtcgt gggtgcagcg      120

attgccgccc ctgttgctgg acagcagaat gtgatcgatc cctggatacg caataatttc      180

gtgcaggcgc ctggaggcga attcacggtg tctcctagaa atgccccagg cgaaattctg      240

tggtcagctc ctctggggcc cgacttgaac ccatacctca gtcatctcgc acgaatgtac      300

aacgggtatg ccggaggctt tgaagtgcag gtgatccttg ccggaaacgc attcaccgcc      360

gggaaagtca tcttcgccgc tgtcccaccc aatttcccta ccgaagggct ttcaccaagt      420

caggtaacca tgtttccaca catcgttgtg gatgtccgcc agcttgaacc tgtactcatc      480

cctctgccag atgttaggaa caacttctac cactacaacc agagcaacga tccaaccatt      540

aagctgatcg ccatgttgta tacaccactc agagccaata acgcaggcga tgatgtgttc      600

actgtctctt gtagagtcct gacacgaccc tctcccgatt tcgacttcat tttcctcgtg      660

ccacccaccg ttgagagccg gacaaaaccg tttagcgtac ccgtgctgac tgtcgaggag      720

atgaccaatt ctaggttccc cattcctctg gagaagctgt ttactggacc gtccagcgcc      780

tttgttgtgc agccacagaa cggccgctgt actactgatg gcgtgctgct tggtacaacc      840

caactgagcc cagtgaatat ctgcaccttc agaggggacg tgactcatat caccggatcc      900

cgcaactaca caatgaacct ggcttcacag aactggaatg actacgatcc aacggaggaa      960

ataccggctc ctctgggtac tccggacttc gtcggcaaga ttcagggagt gctgacccaa     1020

actacccgta ctgatgggag cacccgtggc cacaaagcta ccgtgtatac aggcagtgct     1080

gactttgcgc ctaaactggg tagggtgcaa tttgagactg acaccgatcg ggactttgag     1140

gccaatcaga ataccaagtt tacacccgtc ggcgtcatac aggacggcgg gacgacacat     1200

cgcaacgaac cccagcaatg ggtattgccc tcctattccg gtagaaacac gcacaacgtt     1260

cacttggcac cagccgtggc ccctaccttt cctggagagc aactgctgtt cttccgatct     1320

acaatgccgg ggtgtagtgg ctatccaaac atggacctcg actgcctcct gccccaagag     1380

tgggttcagt acttttatca ggaagccgca cccgcccaga gcgacgttgc actgttgcgg     1440

tttgtaaatc ccgatacggg tcgggtgctc ttcgagtgca agctgcataa atcaggctat     1500

gtcacagtgg cacacacagg gcaacatgac cttgtgattc cgcctaacgg ttacttccgg     1560

tttgacagct gggtgaatca gttttacact ctggctccta tgggaaatgg gacaggcagg     1620

agaagggcgg tttgatagcc taccctccat cattgttata aaaaacttag gaaccaggtc     1680

cacacagccg ccagcccatc aacggccacc atggcaggag ccttctttgc aggattggca     1740

agcgatgttc tgggctccgg acttggttcc ctgatcaacg caggagctgg cgccatcaat     1800

cagaaggtcg aattcgagaa caatcggaag ctgcagcaag cttcctttca gttctctagc     1860

aatctgcagc aagcctcatt tcagcatgac aaagagatgc tgcaggctca gatagaggcc     1920

acgaagaaac tgcagcaaga gatgatgaaa gtgaagcaag cgatgctcct tgaaggtggc     1980

ttctttgaga ctgacgctgc gagaggcgcc attaatgccc cgatgacgaa agccctggac     2040

tggtcaggga ccaggtattg ggctcctgat gcccgcacca ctacatacaa cgccggtcgc     2100

ttttccactc ctcaaccatc aggggcactc ccaggacggg cgaatctgag ggatgctgtg     2160

cccgcaagag gcagcagctc caagagcagt aacagctcaa ccgctacaag cgtgtacagc     2220

aaccagacga cctcaacccg gttgggctcc acagccgtat ctggtacctc tgtgagctct     2280

ttcccctcta ctgcccgtac tcgaagttgg gtggaagatc agtcccggaa tctctctccc     2340

agtatgcgtg gggctcacaa catcagcttc gttaccccac cctctagtcg ctcaagtagc     2400

cagggcacag tgtccacagt ccctaaagaa gtcctggact cctggacagg ggcctttaac     2460

accagaaggc agcctctctt cgcccacatt aggaagagag gggagagtcg agcataatga     2520

gcgcgc                                                                2526


<210>  9
<211>  17634
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MV Noro VP1 optimized cDNA plus strand

<400>  9
accaaacaaa gttgggtaag gatagttcaa tcaatgatca tcttctagtg cacttaggat       60

tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg gccacacttt      120

taaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg      180

gtggagccat cagaggaatc aaacacatta ttatagtacc aatccctgga gattcctcaa      240

ttaccactcg atccagactt ctggaccggt tggtgaggtt aattggaaac ccggatgtga      300

gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag      360

gtcaattgat tcagaggatc accgatgacc ctgacgttag cataaggctg ttagaggttg      420

tccagagtga ccagtcacaa tctggcctta ccttcgcatc aagaggtacc aacatggagg      480

atgaggcgga ccaatacttt tcacatgatg atccaattag tagtgatcaa tccaggttcg      540

gatggttcgg gaacaaggaa atctcagata ttgaagtgca agaccctgag ggattcaaca      600

tgattctggg taccatccta gcccaaattt gggtcttgct cgcaaaggcg gttacggccc      660

cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg      720

tagttggtga atttagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg      780

aggacctctc cttacgccga ttcatggtcg ctctaatcct ggatatcaag agaacacccg      840

gaaacaaacc caggattgct gaaatgatat gtgacattga tacatatatc gtagaggcag      900

gattagccag ttttatcctg actattaagt ttgggataga aactatgtat cctgctcttg      960

gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaac ctttaccagc     1020

aaatggggga aactgcaccc tacatggtaa tcctggagaa ctcaattcag aacaagttca     1080

gtgcaggatc ataccctctg ctctggagct atgccatggg agtaggagtg gaacttgaaa     1140

actccatggg aggtttgaac tttggccgat cttactttga tccagcatat tttagattag     1200

ggcaagagat ggtaaggagg tcagctggaa aggtcagttc cacattggca tctgaactcg     1260

gtatcactgc cgaggatgca aggcttgttt cagagattgc aatgcatact actgaggaca     1320

agatcagtag agcggttgga cccagacaag cccaagtatc atttctacac ggtgatcaaa     1380

gtgagaatga gctaccgaga ttggggggca aggaagatag gagggtcaaa cagagtcgag     1440

gagaagccag ggagagctac agagaaaccg ggcccagcag agcaagtgat gcgagagctg     1500

cccatcttcc aaccggcaca cccctagaca ttgacactgc aacggagtcc agccaagatc     1560

cgcaggacag tcgaaggtca gctgacgccc tgcttaggct gcaagccatg gcaggaatct     1620

cggaagaaca aggctcagac acggacaccc ctatagtgta caatgacaga aatcttctag     1680

actaggtgcg agaggccgag ggccagaaca acatccgcct accatccatc attgttataa     1740

aaaacttagg aaccaggtcc acacagccgc cagcccatca accatccact cccacgattg     1800

gagccaatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct     1860

ctcaaggccg agcccatcgg ctcactggcc atcgaggaag ctatggcagc atggtcagaa     1920

atatcagaca acccaggaca ggagcgagcc acctgcaggg aagagaaggc aggcagttcg     1980

ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc     2040

cgcggtcagg gacctggaga gagcgatgac gacgctgaaa ctttgggaat ccccccaaga     2100

aatctccagg catcaagcac tgggttacag tgttattacg tttatgatca cagcggtgaa     2160

gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat     2220

agcaccctct caggaggaga caatgaatct gaaaacagcg atgtggatat tggcgaacct     2280

gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggggttcagg     2340

gcttctgatg ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatcc     2400

agaggcaaca actttccgaa gcttgggaaa actctcaatg ttcctccgcc cccggacccc     2460

ggtagggcca gcacttccgg gacacccatt aaaaagggca cagacgcgag attagcctca     2520

tttggaacgg agatcgcgtc tttattgaca ggtggtgcaa cccaatgtgc tcgaaagtca     2580

ccctcggaac catcagggcc aggtgcacct gcggggaatg tccccgagtg tgtgagcaat     2640

gccgcactga tacaggagtg gacacccgaa tctggtacca caatctcccc gagatcccag     2700

aataatgaag aagggggaga ctattatgat gatgagctgt tctctgatgt ccaagatatt     2760

aaaacagcct tggccaaaat acacgaggat aatcagaaga taatctccaa gctagaatca     2820

ctgctgttat tgaagggaga agttgagtca attaagaagc agatcaacag gcaaaatatc     2880

agcatatcca ccctggaagg acacctctca agcatcatga tcgccattcc tggacttggg     2940

aaggatccca acgaccccac tgcagatgtc gaaatcaatc ccgacttgaa acccatcata     3000

ggcagagatt caggccgagc actggccgaa gttctcaaga aacccgttgc cagccgacaa     3060

ctccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa ggaatttcag     3120

ctaaagccga tcgggaaaaa gatgagctca gccgtcgggt ttgttcctga caccggccct     3180

gcatcacgca gtgtaatccg ctccattata aaatccagcc ggctagagga ggatcggaag     3240

cgttacctga tgactctcct tgatgatatc aaaggagcca atgatcttgc caagttccac     3300

cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg     3360

ccagtcgacc caactagcct accctccatc attgttataa aaaacttagg aaccaggtcc     3420

acacagccgc cagcccatca acgcgtacgg ccaccatgaa gatggcctct tctgacgcca     3480

acccttcaga cggctcagct gccaatttgg tgcctgaggt gaacaacgag gtgatggccc     3540

tggaacccgt ggtcggagcc gctatagccg caccagttgc cggccagcag aatgtcatcg     3600

acccgtggat tcggaataac ttcgtgcaag cgccgggcgg tgagttcacc gtcagcccac     3660

gaaatgcccc aggcgagatc ctgtggagtg ctccattggg gcctgatctt aacccatacc     3720

tgtcacactt ggcgagaatg tacaatgggt atgcaggagg atttgaggtc caggttattc     3780

tggctgggaa tgctttcaca gcagggaagg tgattttcgc cgccgtccct cctaactttc     3840

ccacagaggg tctgagccca agtcaggtca ccatgttccc acacattgtg gtagatgtga     3900

gacagctcga gcctgtcctg attccacttc cagacgttag gaacaacttt taccactaca     3960

atcagagcaa cgatcccacc atcaagctca ttgccatgct gtatacaccc ctgagagcca     4020

acaatgctgg ggatgacgtc tttactgtga gctgtcgcgt tctgacgcgg ccctcccctg     4080

actttgactt catcttcctc gttcctccaa cggtggaatc caggacgaag ccattctcag     4140

tccctgtcct cactgtggag gaaatgacca atagcaggtt tcctatccct ctggagaaac     4200

tgttcactgg cccgagctcc gcatttgtgg tacagcctca gaacgggaga tgtaccacag     4260

atggcgtgct tctcggcaca acccaactct ctccagtgaa tatctgcacg tttcgtggcg     4320

acgtaaccca catcactgga agcaggaatt acaccatgaa tctcgccagt caaaactgga     4380

acgactacga ccccacagaa gaaatacccg cacccctggg gacaccagat tttgtgggta     4440

aaatccaggg agtactgact caaaccaccc gaactgacgg ttctactcgg ggccataaag     4500

ccactgtgta taccgggagc gcggatttcg ctcccaaatt gggacgcgta cagtttgaga     4560

cagatactga tcgggacttc gaagcaaacc agaacaccaa gttcactccc gttggcgtta     4620

ttcaggatgg aggcaccacc catcgaaatg agccgcagca atgggtactg ccctcctaca     4680

gtggacggaa tacgcataac gtgcatctgg ctcctgcagt tgctcctact ttccccggcg     4740

agcagctgct gttcttccgc tctaccatgc ccgggtgtag cgggtatccc aacatggacc     4800

ttgactgctt gcttccccaa gaatgggtgc agtacttcta tcaggaagcc gctcctgcgc     4860

agtctgatgt ggcactcctg cgctttgtga acccggatac aggaagagtg ctgtttgaat     4920

gcaagctgca caaatccgga tacgtgacag tcgctcacac aggtcaacat gatctggtta     4980

taccaccgaa tggctatttc cgctttgact cctgggtgaa tcagttttat accctggcac     5040

ccatgggtaa cggtacaggc cgtaggagag ccgtctaatg agcgcgcagc gcttagacgt     5100

ctcgcgatcg atactagtac aacctaaatc cattataaaa aacttaggag caaagtgatt     5160

gcctcccaag gtccacaatg acagagacct acgacttcga caagtcggca tgggacatca     5220

aagggtcgat cgctccgata caacccacca cctacagtga tggcaggctg gtgccccagg     5280

tcagagtcat agatcctggt ctaggcgaca ggaaggatga atgctttatg tacatgtttc     5340

tgctgggggt tgttgaggac agcgattccc tagggcctcc aatcgggcga gcatttgggt     5400

tcctgccctt aggtgttggc agatccacag caaagcccga aaaactcctc aaagaggcca     5460

ctgagcttga catagttgtt agacgtacag cagggctcaa tgaaaaactg gtgttctaca     5520

acaacacccc actaactctc ctcacacctt ggagaaaggt cctaacaaca gggagtgtct     5580

tcaacgcaaa ccaagtgtgc aatgcggtta atctgatacc gctcgatacc ccgcagaggt     5640

tccgtgttgt ttatatgagc atcacccgtc tttcggataa cgggtattac accgttccta     5700

gaagaatgct ggaattcaga tcggtcaatg cagtggcctt caacctgctg gtgaccctta     5760

ggattgacaa ggcgataggc cctgggaaga tcatcgacaa tacagagcaa cttcctgagg     5820

caacatttat ggtccacatc gggaacttca ggagaaagaa gagtgaagtc tactctgccg     5880

attattgcaa aatgaaaatc gaaaagatgg gcctggtttt tgcacttggt gggatagggg     5940

gcaccagtct tcacattaga agcacaggca aaatgagcaa gactctccat gcacaactcg     6000

ggttcaagaa gaccttatgt tacccgctga tggatatcaa tgaagacctt aatcgattac     6060

tctggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca tcagttcctc     6120

aagaattccg catttacgac gacgtgatca taaatgatga ccaaggacta ttcaaagttc     6180

tgtagaccgt agtgcccagc aatgcccgaa aacgaccccc ctcacaatga cagccagaag     6240

gcccggacaa aaaagccccc tccgaaagac tccacggacc aagcgagagg ccagccagca     6300

gccgacggca agcgcgaaca ccaggcggcc ccagcacaga acagccctga cacaaggcca     6360

ccaccagcca ccccaatctg catcctcctc gtgggacccc cgaggaccaa cccccaaggc     6420

tgcccccgat ccaaaccacc aaccgcatcc ccaccacccc cgggaaagaa acccccagca     6480

attggaaggc ccctccccct cttcctcaac acaagaactc cacaaccgaa ccgcacaagc     6540

gaccgaggtg acccaaccgc aggcatccga ctccctagac agatcctctc tccccggcaa     6600

actaaacaaa acttagggcc aaggaacata cacacccaac agaacccaga ccccggccca     6660

cggcgccgcg cccccaaccc ccgacaacca gagggagccc ccaaccaatc ccgccggctc     6720

ccccggtgcc cacaggcagg gacaccaacc cccgaacaga cccagcaccc aaccatcgac     6780

aatccaagac gggggggccc ccccaaaaaa aggcccccag gggccgacag ccagcaccgc     6840

gaggaagccc acccacccca cacacgacca cggcaaccaa accagaaccc agaccaccct     6900

gggccaccag ctcccagact cggccatcac cccgcagaaa ggaaaggcca caacccgcgc     6960

accccagccc cgatccggcg gggagccacc caacccgaac cagcacccaa gagcgatccc     7020

cgaaggaccc ccgaaccgca aaggacatca gtatcccaca gcctctccaa gtcccccggt     7080

ctcctcctct tctcgaaggg accaaaagat caatccacca cacccgacga cactcaactc     7140

cccaccccta aaggagacac cgggaatccc agaatcaaga ctcatccaat gtccatcatg     7200

ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct ccaaacaccc     7260

accggtcaaa tccattgggg caatctctct aagatagggg tggtaggaat aggaagtgca     7320

agctacaaag ttatgactcg ttccagccat caatcattag tcataaaatt aatgcccaat     7380

ataactctcc tcaataactg cacgagggta gagattgcag aatacaggag actactgaga     7440

acagttttgg aaccaattag agatgcactt aatgcaatga cccagaatat aagaccggtt     7500

cagagtgtag cttcaagtag gagacacaag agatttgcgg gagtagtcct ggcaggtgcg     7560

gccctaggcg ttgccacagc tgctcagata acagccggca ttgcacttca ccagtccatg     7620

ctgaactctc aagccatcga caatctgaga gcgagcctgg aaactactaa tcaggcaatt     7680

gagacaatca gacaagcagg gcaggagatg atattggctg ttcagggtgt ccaagactac     7740

atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag     7800

ctcgggctca aattgctcag atactataca gaaatcctgt cattatttgg ccccagttta     7860

cgggacccca tatctgcgga gatatctatc caggctttga gctatgcgct tggaggagac     7920

atcaataagg tgttagaaaa gctcggatac agtggaggtg atttactggg catcttagag     7980

agcggaggaa taaaggcccg gataactcac gtcgacacag agtcctactt cattgtcctc     8040

agtatagcct atccgacgct gtccgagatt aagggggtga ttgtccaccg gctagagggg     8100

gtctcgtaca acataggctc tcaagagtgg tataccactg tgcccaagta tgttgcaacc     8160

caagggtacc ttatctcgaa ttttgatgag tcatcgtgta ctttcatgcc agaggggact     8220

gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg cctccggggg     8280

tacaccaagt cctgtgctcg tacactcgta tccgggtctt ttgggaaccg gttcatttta     8340

tcacaaggga acctaatagc caattgtgca tcaatccttt gcaagtgtta cacaacagga     8400

acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga tcactgcccg     8460

gtagtcgagg tgaacggcgt gaccatccaa gtcgggagca ggaggtatcc agacgctgtg     8520

tacttgcaca gaattgacct cggtcctccc atatcattgg agaggttgga cgtagggaca     8580

aatctgggga atgcaattgc taagttggag gatgccaagg aattgttgga gtcatcggac     8640

cagatattga ggagtatgaa aggtttatcg agcactagca tagtctacat cctgattgca     8700

gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag ggggcgttgt     8760

aacaaaaagg gagaacaagt tggtatgtca agaccaggcc taaagcctga tcttacggga     8820

acatcaaaat cctatgtaag gtcgctctga tcctctacaa ctcttgaaac acaaatgtcc     8880

cacaagtctc ctcttcgtca tcaagcaacc accgcaccca gcatcaagcc cacctgaaat     8940

tatctccggc ttccctctgg ccgaacaata tcggtagtta atcaaaactt agggtgcaag     9000

atcatccaca atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca     9060

tcccaaggga agtaggatag tcattaacag agaacatctt atgattgata gaccttatgt     9120

tttgctggct gttctgtttg tcatgtttct gagcttgatc gggttgctag ccattgcagg     9180

cattagactt catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa     9240

tctagatgta actaactcaa tcgagcatca ggtcaaggac gtgctgacac cactcttcaa     9300

aatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt     9360

aatctctgac aagattaaat tccttaatcc ggatagggag tacgacttca gagatctcac     9420

ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt     9480

ggctgctgaa gagctcatga atgcattggt gaactcaact ctactggaga ccagaacaac     9540

caatcagttc ctagctgtct caaagggaaa ctgctcaggg cccactacaa tcagaggtca     9600

attctcaaac atgtcgctgt ccctgttaga cttgtattta ggtcgaggtt acaatgtgtc     9660

atctatagtc actatgacat cccagggaat gtatggggga acttacctag tggaaaagcc     9720

taatctgagc agcaaaaggt cagagttgtc acaactgagc atgtaccgag tgtttgaagt     9780

aggtgttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa actatcttga     9840

gcaaccagtc agtaatgatc tcagcaactg tatggtggct ttgggggagc tcaaactcgc     9900

agccctttgt cacggggaag attctatcac aattccctat cagggatcag ggaaaggtgt     9960

cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt    10020

ccccttatca acggatgatc cagtgataga caggctttac ctctcatctc acagaggtgt    10080

tatcgctgac aatcaagcaa aatgggctgt cccgacaaca cgaacagatg acaagttgcg    10140

aatggagaca tgcttccaac aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc    10200

cgagtgggca ccattgaagg ataacaggat tccttcatac ggggtcttgt ctgttgatct    10260

gagtctgaca gttgagctta aaatcaaaat tgcttcggga ttcgggccat tgatcacaca    10320

cggttcaggg atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc    10380

gccaatgaag aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa    10440

ggttagtccc tacctcttca ctgtcccaat taaggaagca ggcgaagact gccatgcccc    10500

aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct    10560

acctggtcaa gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc    10620

tgtggtttat tacgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt    10680

gcctataaag ggggtcccca tcgaattaca agtggaatgc ttcacatggg accaaaaact    10740

ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc    10800

tgggatggtg ggcatgggag tcagctgcac agtcacccgg gaagatggaa ccaatcgcag    10860

atagggctgc tagtgaacca atcacatgat gtcacccaga catcaggcat acccactagt    10920

gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggttcccc gttatggact    10980

cgctatctgt caaccagatc ttataccctg aagttcacct agatagcccg atagttacca    11040

ataagatagt agccatcctg gagtatgctc gagtccctca cgcttacagc ctggaggacc    11100

ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attttccaac caaatgatta    11160

taaacaatgt ggaagttggg aatgtcatca agtccaagct taggagttat ccggcccact    11220

ctcatattcc atatccaaat tgtaatcagg atttatttaa catagaagac aaagagtcaa    11280

cgaggaagat ccgtgaactc ctcaaaaagg ggaattcgct gtactccaaa gtcagtgata    11340

aggttttcca atgcttaagg gacactaact cacggcttgg cctaggctcc gaattgaggg    11400

aggacatcaa ggagaaagtt attaacttgg gagtttacat gcacagctcc cagtggtttg    11460

agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt aaatcacaaa    11520

cccatacttg ccataggagg agacacacac ctgtattctt cactggtagt tcagttgagt    11580

tgctaatctc tcgtgacctt gttgctataa tcagtaaaga gtctcaacat gtatattacc    11640

tgacatttga actggttttg atgtattgtg atgtcataga ggggaggtta atgacagaga    11700

ccgctatgac tattgatgct aggtatacag agcttctagg aagagtcaga tacatgtgga    11760

aactgataga tggtttcttc cctgcactcg ggaatccaac ttatcaaatt gtagccatgc    11820

tggagcctct ttcacttgct tacctgcagc tgagggatat aacagtagaa ctcagaggtg    11880

ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac gggttttctg    11940

atgaaggtac ttatcatgag ttaactgaag ctctagatta cattttcata actgatgaca    12000

tacatctgac aggggagatt ttctcatttt tcagaagttt cggccacccc agacttgaag    12060

cagtaacggc tgctgaaaat gttaggaaat acatgaatca gcctaaagtc attgtgtatg    12120

agactctgat gaaaggtcat gccatatttt gtggaatcat aatcaacggc tatcgtgaca    12180

ggcacggagg cagttggcca ccgctgaccc tccccctgca tgctgcagac acaatccgga    12240

atgctcaagc ttcaggtgaa gggttaacac atgagcagtg cgttgataac tggaaatctt    12300

ttgctggagt gaaatttggc tgctttatgc ctcttagcct ggatagtgat ctgacaatgt    12360

acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt tacccgaaag    12420

agttcctgcg ttacgaccct cccaagggaa ccgggtcacg gaggcttgta gatgttttcc    12480

ttaatgattc gagctttgac ccatatgatg tgataatgta tgttgtaagt ggagcttacc    12540

tccatgaccc tgagttcaac ctgtcttaca gcctgaaaga aaaggagatc aaggaaacag    12600

gtagactttt tgctaaaatg acttacaaaa tgagggcatg ccaagtgatt gctgaaaatc    12660

taatctcaaa cgggattggc aaatatttta aggacaatgg gatggccaag gatgagcacg    12720

atttgactaa ggcactccac actctagctg tctcaggagt ccccaaagat ctcaaagaaa    12780

gtcacagggg ggggccagtc ttaaaaacct actcccgaag cccagtccac acaagtacca    12840

ggaacgtgag agcagcaaaa gggtttatag ggttccctca agtaattcgg caggaccaag    12900

acactgatca tccggagaat atggaagctt acgagacagt cagtgcattt atcacgactg    12960

atctcaagaa gtactgcctt aattggagat atgagaccat cagcttgttt gcacagaggc    13020

taaatgagat ttacggattg ccctcatttt tccagtggct gcataagagg cttgagacct    13080

ctgtcctgta tgtaagtgac cctcattgcc cccccgacct tgacgcccat atcccgttat    13140

ataaagtccc caatgatcaa atcttcatta agtaccctat gggaggtata gaagggtatt    13200

gtcagaagct gtggaccatc agcaccattc cctatctata cctggctgct tatgagagcg    13260

gagtaaggat tgcttcgtta gtgcaagggg acaatcagac catagccgta acaaaaaggg    13320

tacccagcac atggccctac aaccttaaga aacgggaagc tgctagagta actagagatt    13380

actttgtaat tcttaggcaa aggctacatg atattggcca tcacctcaag gcaaatgaga    13440

caattgtttc atcacatttt tttgtctatt caaaaggaat atattatgat gggctacttg    13500

tgtcccaatc actcaagagc atcgcaagat gtgtattctg gtcagagact atagttgatg    13560

aaacaagggc agcatgcagt aatattgcta caacaatggc taaaagcatc gagagaggtt    13620

atgaccgtta ccttgcatat tccctgaacg tcctaaaagt gatacagcaa attctgatct    13680

ctcttggctt cacaatcaat tcaaccatga cccgggatgt agtcataccc ctcctcacaa    13740

acaacgacct cttaataagg atggcactgt tgcccgctcc tattgggggg atgaattatc    13800

tgaatatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca tcaattgctg    13860

atctcaagag aatgattctc gcctcactaa tgcctgaaga gaccctccat caagtaatga    13920

cacaacaacc gggggactct tcattcctag actgggctag cgacccttac tcagcaaatc    13980

ttgtatgtgt ccagagcatc actagactcc tcaagaacat aactgcaagg tttgtcctga    14040

tccatagtcc aaacccaatg ttaaaaggat tattccatga tgacagtaaa gaagaggacg    14100

agggactggc ggcattcctc atggacaggc atattatagt acctagggca gctcatgaaa    14160

tcctggatca tagtgtcaca ggggcaagag agtctattgc aggcatgctg gataccacaa    14220

aaggcttgat tcgagccagc atgaggaagg gggggttaac ctctcgagtg ataaccagat    14280

tgtccaatta tgactatgaa caattcagag cagggatggt gctattgaca ggaagaaaga    14340

gaaatgtcct cattgacaaa gagtcatgtt cagtgcagct ggcgagagct ctaagaagcc    14400

atatgtgggc gaggctagct cgaggacggc ctatttacgg ccttgaggtc cctgatgtac    14460

tagaatctat gcgaggccac cttattcggc gtcatgagac atgtgtcatc tgcgagtgtg    14520

gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat gatattgaca    14580

aggaaacatc atccttgaga gtcccatata ttggttctac cactgatgag agaacagaca    14640

tgaagcttgc cttcgtaaga gccccaagtc gatccttgcg atctgctgtt agaatagcaa    14700

cagtgtactc atgggcttac ggtgatgatg atagctcttg gaacgaagcc tggttgttgg    14760

ctaggcaaag ggccaatgtg agcctggagg agctaagggt gatcactccc atctcaactt    14820

cgactaattt agcgcatagg ttgagggatc gtagcactca agtgaaatac tcaggtacat    14880

cccttgtccg agtggcgagg tataccacaa tctccaacga caatctctca tttgtcatat    14940

cagataagaa ggttgatact aactttatat accaacaagg aatgcttcta gggttgggtg    15000

ttttagaaac attgtttcga ctcgagaaag ataccggatc atctaacacg gtattacatc    15060

ttcacgtcga aacagattgt tgcgtgatcc cgatgataga tcatcccagg atacccagct    15120

cccgcaagct agagctgagg gcagagctat gtaccaaccc attgatatat gataatgcac    15180

ctttaattga cagagatgca acaaggctat acacccagag ccataggagg caccttgtgg    15240

aatttgttac atggtccaca ccccaactat atcacatttt agctaagtcc acagcactat    15300

ctatgattga cctggtaaca aaatttgaga aggaccatat gaatgaaatt tcagctctca    15360

taggggatga cgatatcaat agtttcataa ctgagtttct gctcatagag ccaagattat    15420

tcactatcta cttgggccag tgtgcggcca tcaattgggc atttgatgta cattatcata    15480

gaccatcagg gaaatatcag atgggtgagc tgttgtcatc gttcctttct agaatgagca    15540

aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac aagaaattct    15600

ggcattgtgg tattatagag cctatccatg gtccttcact tgatgctcaa aacttgcaca    15660

caactgtgtg caacatggtt tacacatgct atatgaccta cctcgacctg ttgttgaatg    15720

aagagttaga agagttcaca tttctcttgt gtgaaagcga cgaggatgta gtaccggaca    15780

gattcgacaa catccaggca aaacacttat gtgttctggc agatttgtac tgtcaaccag    15840

ggacctgccc accaattcga ggtctaagac cggtagagaa atgtgcagtt ctaaccgacc    15900

atatcaaggc agaggctatg ttatctccag caggatcttc gtggaacata aatccaatta    15960

ttgtagacca ttactcatgc tctctgactt atctccggcg aggatcgatc aaacagataa    16020

gattgagagt tgatccagga ttcattttcg acgccctcgc tgaggtaaat gtcagtcagc    16080

caaagatcgg cagcaacaac atctcaaata tgagcatcaa ggctttcaga cccccacacg    16140

atgatgttgc aaaattgctc aaagatatca acacaagcaa gcacaatctt cccatttcag    16200

ggggcaatct cgccaattat gaaatccatg ctttccgcag aatcgggttg aactcatctg    16260

cttgctacaa agctgttgag atatcaacat taattaggag atgccttgag ccaggggagg    16320

acggcttgtt cttgggtgag ggatcgggtt ctatgttgat cacttataaa gagatactta    16380

aactaaacaa gtgcttctat aatagtgggg tttccgccaa ttctagatct ggtcaaaggg    16440

aattagcacc ctatccctcc gaagttggcc ttgtcgaaca cagaatggga gtaggtaata    16500

ttgtcaaagt gctctttaac gggaggcccg aagtcacgtg ggtaggcagt gtagattgct    16560

tcaatttcat agttagtaat atccctacct ctagtgtggg gtttatccat tcagatatag    16620

agaccttgcc tgacaaagat actatagaga agctagagga attggcagcc atcttatcga    16680

tggctctgct cctgggcaaa ataggatcaa tactggtgat taagcttatg cctttcagcg    16740

gggattttgt tcagggattt ataagttatg tagggtctca ttatagagaa gtgaaccttg    16800

tataccctag atacagcaac ttcatctcta ctgaatctta tttggttatg acagatctca    16860

aggctaaccg gctaatgaat cctgaaaaga ttaagcagca gataattgaa tcatctgtga    16920

ggacttcacc tggacttata ggtcacatcc tatccattaa gcaactaagc tgcatacaag    16980

caattgtggg agacgcagtt agtagaggtg atatcaatcc tactctgaaa aaacttacac    17040

ctatagagca ggtgctgatc aattgcgggt tggcaattaa cggacctaag ctgtgcaaag    17100

aattgatcca ccatgatgtt gcctcagggc aagatggatt gcttaattct atactcatcc    17160

tctacaggga gttggcaaga ttcaaagaca accaaagaag tcaacaaggg atgttccacg    17220

cttaccccgt attggtaagt agcaggcaac gagaacttat atctaggatc acccgcaaat    17280

tctgggggca cattcttctt tactccggga acaaaaagtt gataaataag tttatccaga    17340

atctcaagtc cggctatctg atactagact tacaccagaa tatcttcgtt aagaatctat    17400

ccaagtcaga gaaacagatt attatgacgg ggggtttgaa acgtgagtgg gtttttaagg    17460

taacagtcaa ggagaccaaa gaatggtata agttagtcgg atacagtgcc ctgattaagg    17520

actaattggt tgaactccgg aaccctaatc ctgccctagg tggttaggca ttatttgcaa    17580

tatattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc tggt          17634


<210>  10
<211>  18516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MV Noro VP1 ATU VP2 optimized cDNA plus strand

<400>  10
accaaacaaa gttgggtaag gatagttcaa tcaatgatca tcttctagtg cacttaggat       60

tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg gccacacttt      120

taaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg      180

gtggagccat cagaggaatc aaacacatta ttatagtacc aatccctgga gattcctcaa      240

ttaccactcg atccagactt ctggaccggt tggtgaggtt aattggaaac ccggatgtga      300

gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag      360

gtcaattgat tcagaggatc accgatgacc ctgacgttag cataaggctg ttagaggttg      420

tccagagtga ccagtcacaa tctggcctta ccttcgcatc aagaggtacc aacatggagg      480

atgaggcgga ccaatacttt tcacatgatg atccaattag tagtgatcaa tccaggttcg      540

gatggttcgg gaacaaggaa atctcagata ttgaagtgca agaccctgag ggattcaaca      600

tgattctggg taccatccta gcccaaattt gggtcttgct cgcaaaggcg gttacggccc      660

cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg      720

tagttggtga atttagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg      780

aggacctctc cttacgccga ttcatggtcg ctctaatcct ggatatcaag agaacacccg      840

gaaacaaacc caggattgct gaaatgatat gtgacattga tacatatatc gtagaggcag      900

gattagccag ttttatcctg actattaagt ttgggataga aactatgtat cctgctcttg      960

gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaac ctttaccagc     1020

aaatggggga aactgcaccc tacatggtaa tcctggagaa ctcaattcag aacaagttca     1080

gtgcaggatc ataccctctg ctctggagct atgccatggg agtaggagtg gaacttgaaa     1140

actccatggg aggtttgaac tttggccgat cttactttga tccagcatat tttagattag     1200

ggcaagagat ggtaaggagg tcagctggaa aggtcagttc cacattggca tctgaactcg     1260

gtatcactgc cgaggatgca aggcttgttt cagagattgc aatgcatact actgaggaca     1320

agatcagtag agcggttgga cccagacaag cccaagtatc atttctacac ggtgatcaaa     1380

gtgagaatga gctaccgaga ttggggggca aggaagatag gagggtcaaa cagagtcgag     1440

gagaagccag ggagagctac agagaaaccg ggcccagcag agcaagtgat gcgagagctg     1500

cccatcttcc aaccggcaca cccctagaca ttgacactgc aacggagtcc agccaagatc     1560

cgcaggacag tcgaaggtca gctgacgccc tgcttaggct gcaagccatg gcaggaatct     1620

cggaagaaca aggctcagac acggacaccc ctatagtgta caatgacaga aatcttctag     1680

actaggtgcg agaggccgag ggccagaaca acatccgcct accatccatc attgttataa     1740

aaaacttagg aaccaggtcc acacagccgc cagcccatca accatccact cccacgattg     1800

gagccaatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct     1860

ctcaaggccg agcccatcgg ctcactggcc atcgaggaag ctatggcagc atggtcagaa     1920

atatcagaca acccaggaca ggagcgagcc acctgcaggg aagagaaggc aggcagttcg     1980

ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc     2040

cgcggtcagg gacctggaga gagcgatgac gacgctgaaa ctttgggaat ccccccaaga     2100

aatctccagg catcaagcac tgggttacag tgttattacg tttatgatca cagcggtgaa     2160

gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat     2220

agcaccctct caggaggaga caatgaatct gaaaacagcg atgtggatat tggcgaacct     2280

gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggggttcagg     2340

gcttctgatg ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatcc     2400

agaggcaaca actttccgaa gcttgggaaa actctcaatg ttcctccgcc cccggacccc     2460

ggtagggcca gcacttccgg gacacccatt aaaaagggca cagacgcgag attagcctca     2520

tttggaacgg agatcgcgtc tttattgaca ggtggtgcaa cccaatgtgc tcgaaagtca     2580

ccctcggaac catcagggcc aggtgcacct gcggggaatg tccccgagtg tgtgagcaat     2640

gccgcactga tacaggagtg gacacccgaa tctggtacca caatctcccc gagatcccag     2700

aataatgaag aagggggaga ctattatgat gatgagctgt tctctgatgt ccaagatatt     2760

aaaacagcct tggccaaaat acacgaggat aatcagaaga taatctccaa gctagaatca     2820

ctgctgttat tgaagggaga agttgagtca attaagaagc agatcaacag gcaaaatatc     2880

agcatatcca ccctggaagg acacctctca agcatcatga tcgccattcc tggacttggg     2940

aaggatccca acgaccccac tgcagatgtc gaaatcaatc ccgacttgaa acccatcata     3000

ggcagagatt caggccgagc actggccgaa gttctcaaga aacccgttgc cagccgacaa     3060

ctccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa ggaatttcag     3120

ctaaagccga tcgggaaaaa gatgagctca gccgtcgggt ttgttcctga caccggccct     3180

gcatcacgca gtgtaatccg ctccattata aaatccagcc ggctagagga ggatcggaag     3240

cgttacctga tgactctcct tgatgatatc aaaggagcca atgatcttgc caagttccac     3300

cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg     3360

ccagtcgacc caactagcct accctccatc attgttataa aaaacttagg aaccaggtcc     3420

acacagccgc cagcccatca acgcgtacgg ccaccatgaa gatggcttcc tctgacgcca     3480

atccttccga tggaagcgct gctaatctgg tgcccgaggt caacaacgag gtaatggcac     3540

tggaacccgt cgtgggtgca gcgattgccg cccctgttgc tggacagcag aatgtgatcg     3600

atccctggat acgcaataat ttcgtgcagg cgcctggagg cgaattcacg gtgtctccta     3660

gaaatgcccc aggcgaaatt ctgtggtcag ctcctctggg gcccgacttg aacccatacc     3720

tcagtcatct cgcacgaatg tacaacgggt atgccggagg ctttgaagtg caggtgatcc     3780

ttgccggaaa cgcattcacc gccgggaaag tcatcttcgc cgctgtccca cccaatttcc     3840

ctaccgaagg gctttcacca agtcaggtaa ccatgtttcc acacatcgtt gtggatgtcc     3900

gccagcttga acctgtactc atccctctgc cagatgttag gaacaacttc taccactaca     3960

accagagcaa cgatccaacc attaagctga tcgccatgtt gtatacacca ctcagagcca     4020

ataacgcagg cgatgatgtg ttcactgtct cttgtagagt cctgacacga ccctctcccg     4080

atttcgactt cattttcctc gtgccaccca ccgttgagag ccggacaaaa ccgtttagcg     4140

tacccgtgct gactgtcgag gagatgacca attctaggtt ccccattcct ctggagaagc     4200

tgtttactgg accgtccagc gcctttgttg tgcagccaca gaacggccgc tgtactactg     4260

atggcgtgct gcttggtaca acccaactga gcccagtgaa tatctgcacc ttcagagggg     4320

acgtgactca tatcaccgga tcccgcaact acacaatgaa cctggcttca cagaactgga     4380

atgactacga tccaacggag gaaataccgg ctcctctggg tactccggac ttcgtcggca     4440

agattcaggg agtgctgacc caaactaccc gtactgatgg gagcacccgt ggccacaaag     4500

ctaccgtgta tacaggcagt gctgactttg cgcctaaact gggtagggtg caatttgaga     4560

ctgacaccga tcgggacttt gaggccaatc agaataccaa gtttacaccc gtcggcgtca     4620

tacaggacgg cgggacgaca catcgcaacg aaccccagca atgggtattg ccctcctatt     4680

ccggtagaaa cacgcacaac gttcacttgg caccagccgt ggcccctacc tttcctggag     4740

agcaactgct gttcttccga tctacaatgc cggggtgtag tggctatcca aacatggacc     4800

tcgactgcct cctgccccaa gagtgggttc agtactttta tcaggaagcc gcacccgccc     4860

agagcgacgt tgcactgttg cggtttgtaa atcccgatac gggtcgggtg ctcttcgagt     4920

gcaagctgca taaatcaggc tatgtcacag tggcacacac agggcaacat gaccttgtga     4980

ttccgcctaa cggttacttc cggtttgaca gctgggtgaa tcagttttac actctggctc     5040

ctatgggaaa tgggacaggc aggagaaggg cggtttgata gcctaccctc catcattgtt     5100

ataaaaaact taggaaccag gtccacacag ccgccagccc atcaacggcc accatggcag     5160

gagccttctt tgcaggattg gcaagcgatg ttctgggctc cggacttggt tccctgatca     5220

acgcaggagc tggcgccatc aatcagaagg tcgaattcga gaacaatcgg aagctgcagc     5280

aagcttcctt tcagttctct agcaatctgc agcaagcctc atttcagcat gacaaagaga     5340

tgctgcaggc tcagatagag gccacgaaga aactgcagca agagatgatg aaagtgaagc     5400

aagcgatgct ccttgaaggt ggcttctttg agactgacgc tgcgagaggc gccattaatg     5460

ccccgatgac gaaagccctg gactggtcag ggaccaggta ttgggctcct gatgcccgca     5520

ccactacata caacgccggt cgcttttcca ctcctcaacc atcaggggca ctcccaggac     5580

gggcgaatct gagggatgct gtgcccgcaa gaggcagcag ctccaagagc agtaacagct     5640

caaccgctac aagcgtgtac agcaaccaga cgacctcaac ccggttgggc tccacagccg     5700

tatctggtac ctctgtgagc tctttcccct ctactgcccg tactcgaagt tgggtggaag     5760

atcagtcccg gaatctctct cccagtatgc gtggggctca caacatcagc ttcgttaccc     5820

caccctctag tcgctcaagt agccagggca cagtgtccac agtccctaaa gaagtcctgg     5880

actcctggac aggggccttt aacaccagaa ggcagcctct cttcgcccac attaggaaga     5940

gaggggagag tcgagcataa tgagcgcgca gcgcttagac gtctcgcgat cgatactagt     6000

acaacctaaa tccattataa aaaacttagg agcaaagtga ttgcctccca aggtccacaa     6060

tgacagagac ctacgacttc gacaagtcgg catgggacat caaagggtcg atcgctccga     6120

tacaacccac cacctacagt gatggcaggc tggtgcccca ggtcagagtc atagatcctg     6180

gtctaggcga caggaaggat gaatgcttta tgtacatgtt tctgctgggg gttgttgagg     6240

acagcgattc cctagggcct ccaatcgggc gagcatttgg gttcctgccc ttaggtgttg     6300

gcagatccac agcaaagccc gaaaaactcc tcaaagaggc cactgagctt gacatagttg     6360

ttagacgtac agcagggctc aatgaaaaac tggtgttcta caacaacacc ccactaactc     6420

tcctcacacc ttggagaaag gtcctaacaa cagggagtgt cttcaacgca aaccaagtgt     6480

gcaatgcggt taatctgata ccgctcgata ccccgcagag gttccgtgtt gtttatatga     6540

gcatcacccg tctttcggat aacgggtatt acaccgttcc tagaagaatg ctggaattca     6600

gatcggtcaa tgcagtggcc ttcaacctgc tggtgaccct taggattgac aaggcgatag     6660

gccctgggaa gatcatcgac aatacagagc aacttcctga ggcaacattt atggtccaca     6720

tcgggaactt caggagaaag aagagtgaag tctactctgc cgattattgc aaaatgaaaa     6780

tcgaaaagat gggcctggtt tttgcacttg gtgggatagg gggcaccagt cttcacatta     6840

gaagcacagg caaaatgagc aagactctcc atgcacaact cgggttcaag aagaccttat     6900

gttacccgct gatggatatc aatgaagacc ttaatcgatt actctggagg agcagatgca     6960

agatagtaag aatccaggca gttttgcagc catcagttcc tcaagaattc cgcatttacg     7020

acgacgtgat cataaatgat gaccaaggac tattcaaagt tctgtagacc gtagtgccca     7080

gcaatgcccg aaaacgaccc ccctcacaat gacagccaga aggcccggac aaaaaagccc     7140

cctccgaaag actccacgga ccaagcgaga ggccagccag cagccgacgg caagcgcgaa     7200

caccaggcgg ccccagcaca gaacagccct gacacaaggc caccaccagc caccccaatc     7260

tgcatcctcc tcgtgggacc cccgaggacc aacccccaag gctgcccccg atccaaacca     7320

ccaaccgcat ccccaccacc cccgggaaag aaacccccag caattggaag gcccctcccc     7380

ctcttcctca acacaagaac tccacaaccg aaccgcacaa gcgaccgagg tgacccaacc     7440

gcaggcatcc gactccctag acagatcctc tctccccggc aaactaaaca aaacttaggg     7500

ccaaggaaca tacacaccca acagaaccca gaccccggcc cacggcgccg cgcccccaac     7560

ccccgacaac cagagggagc ccccaaccaa tcccgccggc tcccccggtg cccacaggca     7620

gggacaccaa cccccgaaca gacccagcac ccaaccatcg acaatccaag acgggggggc     7680

ccccccaaaa aaaggccccc aggggccgac agccagcacc gcgaggaagc ccacccaccc     7740

cacacacgac cacggcaacc aaaccagaac ccagaccacc ctgggccacc agctcccaga     7800

ctcggccatc accccgcaga aaggaaaggc cacaacccgc gcaccccagc cccgatccgg     7860

cggggagcca cccaacccga accagcaccc aagagcgatc cccgaaggac ccccgaaccg     7920

caaaggacat cagtatccca cagcctctcc aagtcccccg gtctcctcct cttctcgaag     7980

ggaccaaaag atcaatccac cacacccgac gacactcaac tccccacccc taaaggagac     8040

accgggaatc ccagaatcaa gactcatcca atgtccatca tgggtctcaa ggtgaacgtc     8100

tctgccatat tcatggcagt actgttaact ctccaaacac ccaccggtca aatccattgg     8160

ggcaatctct ctaagatagg ggtggtagga ataggaagtg caagctacaa agttatgact     8220

cgttccagcc atcaatcatt agtcataaaa ttaatgccca atataactct cctcaataac     8280

tgcacgaggg tagagattgc agaatacagg agactactga gaacagtttt ggaaccaatt     8340

agagatgcac ttaatgcaat gacccagaat ataagaccgg ttcagagtgt agcttcaagt     8400

aggagacaca agagatttgc gggagtagtc ctggcaggtg cggccctagg cgttgccaca     8460

gctgctcaga taacagccgg cattgcactt caccagtcca tgctgaactc tcaagccatc     8520

gacaatctga gagcgagcct ggaaactact aatcaggcaa ttgagacaat cagacaagca     8580

gggcaggaga tgatattggc tgttcagggt gtccaagact acatcaataa tgagctgata     8640

ccgtctatga accaactatc ttgtgattta atcggccaga agctcgggct caaattgctc     8700

agatactata cagaaatcct gtcattattt ggccccagtt tacgggaccc catatctgcg     8760

gagatatcta tccaggcttt gagctatgcg cttggaggag acatcaataa ggtgttagaa     8820

aagctcggat acagtggagg tgatttactg ggcatcttag agagcggagg aataaaggcc     8880

cggataactc acgtcgacac agagtcctac ttcattgtcc tcagtatagc ctatccgacg     8940

ctgtccgaga ttaagggggt gattgtccac cggctagagg gggtctcgta caacataggc     9000

tctcaagagt ggtataccac tgtgcccaag tatgttgcaa cccaagggta ccttatctcg     9060

aattttgatg agtcatcgtg tactttcatg ccagagggga ctgtgtgcag ccaaaatgcc     9120

ttgtacccga tgagtcctct gctccaagaa tgcctccggg ggtacaccaa gtcctgtgct     9180

cgtacactcg tatccgggtc ttttgggaac cggttcattt tatcacaagg gaacctaata     9240

gccaattgtg catcaatcct ttgcaagtgt tacacaacag gaacgatcat taatcaagac     9300

cctgacaaga tcctaacata cattgctgcc gatcactgcc cggtagtcga ggtgaacggc     9360

gtgaccatcc aagtcgggag caggaggtat ccagacgctg tgtacttgca cagaattgac     9420

ctcggtcctc ccatatcatt ggagaggttg gacgtaggga caaatctggg gaatgcaatt     9480

gctaagttgg aggatgccaa ggaattgttg gagtcatcgg accagatatt gaggagtatg     9540

aaaggtttat cgagcactag catagtctac atcctgattg cagtgtgtct tggagggttg     9600

atagggatcc ccgctttaat atgttgctgc agggggcgtt gtaacaaaaa gggagaacaa     9660

gttggtatgt caagaccagg cctaaagcct gatcttacgg gaacatcaaa atcctatgta     9720

aggtcgctct gatcctctac aactcttgaa acacaaatgt cccacaagtc tcctcttcgt     9780

catcaagcaa ccaccgcacc cagcatcaag cccacctgaa attatctccg gcttccctct     9840

ggccgaacaa tatcggtagt taatcaaaac ttagggtgca agatcatcca caatgtcacc     9900

acaacgagac cggataaatg ccttctacaa agataacccc catcccaagg gaagtaggat     9960

agtcattaac agagaacatc ttatgattga tagaccttat gttttgctgg ctgttctgtt    10020

tgtcatgttt ctgagcttga tcgggttgct agccattgca ggcattagac ttcatcgggc    10080

agccatctac accgcagaga tccataaaag cctcagcacc aatctagatg taactaactc    10140

aatcgagcat caggtcaagg acgtgctgac accactcttc aaaatcatcg gtgatgaagt    10200

gggcctgagg acacctcaga gattcactga cctagtgaaa ttaatctctg acaagattaa    10260

attccttaat ccggataggg agtacgactt cagagatctc acttggtgta tcaacccgcc    10320

agagagaatc aaattggatt atgatcaata ctgtgcagat gtggctgctg aagagctcat    10380

gaatgcattg gtgaactcaa ctctactgga gaccagaaca accaatcagt tcctagctgt    10440

ctcaaaggga aactgctcag ggcccactac aatcagaggt caattctcaa acatgtcgct    10500

gtccctgtta gacttgtatt taggtcgagg ttacaatgtg tcatctatag tcactatgac    10560

atcccaggga atgtatgggg gaacttacct agtggaaaag cctaatctga gcagcaaaag    10620

gtcagagttg tcacaactga gcatgtaccg agtgtttgaa gtaggtgtta tcagaaatcc    10680

gggtttgggg gctccggtgt tccatatgac aaactatctt gagcaaccag tcagtaatga    10740

tctcagcaac tgtatggtgg ctttggggga gctcaaactc gcagcccttt gtcacgggga    10800

agattctatc acaattccct atcagggatc agggaaaggt gtcagcttcc agctcgtcaa    10860

gctaggtgtc tggaaatccc caaccgacat gcaatcctgg gtccccttat caacggatga    10920

tccagtgata gacaggcttt acctctcatc tcacagaggt gttatcgctg acaatcaagc    10980

aaaatgggct gtcccgacaa cacgaacaga tgacaagttg cgaatggaga catgcttcca    11040

acaggcgtgt aagggtaaaa tccaagcact ctgcgagaat cccgagtggg caccattgaa    11100

ggataacagg attccttcat acggggtctt gtctgttgat ctgagtctga cagttgagct    11160

taaaatcaaa attgcttcgg gattcgggcc attgatcaca cacggttcag ggatggacct    11220

atacaaatcc aaccacaaca atgtgtattg gctgactatc ccgccaatga agaacctagc    11280

cttaggtgta atcaacacat tggagtggat accgagattc aaggttagtc cctacctctt    11340

cactgtccca attaaggaag caggcgaaga ctgccatgcc ccaacatacc tacctgcgga    11400

ggtggatggt gatgtcaaac tcagttccaa tctggtgatt ctacctggtc aagatctcca    11460

atatgttttg gcaacctacg atacttccag ggttgaacat gctgtggttt attacgttta    11520

cagcccaagc cgctcatttt cttactttta tccttttagg ttgcctataa agggggtccc    11580

catcgaatta caagtggaat gcttcacatg ggaccaaaaa ctctggtgcc gtcacttctg    11640

tgtgcttgcg gactcagaat ctggtggaca tatcactcac tctgggatgg tgggcatggg    11700

agtcagctgc acagtcaccc gggaagatgg aaccaatcgc agatagggct gctagtgaac    11760

caatcacatg atgtcaccca gacatcaggc atacccacta gtgtgaaata gacatcagaa    11820

ttaagaaaaa cgtagggtcc aagtggttcc ccgttatgga ctcgctatct gtcaaccaga    11880

tcttataccc tgaagttcac ctagatagcc cgatagttac caataagata gtagccatcc    11940

tggagtatgc tcgagtccct cacgcttaca gcctggagga ccctacactg tgtcagaaca    12000

tcaagcaccg cctaaaaaac ggattttcca accaaatgat tataaacaat gtggaagttg    12060

ggaatgtcat caagtccaag cttaggagtt atccggccca ctctcatatt ccatatccaa    12120

attgtaatca ggatttattt aacatagaag acaaagagtc aacgaggaag atccgtgaac    12180

tcctcaaaaa ggggaattcg ctgtactcca aagtcagtga taaggttttc caatgcttaa    12240

gggacactaa ctcacggctt ggcctaggct ccgaattgag ggaggacatc aaggagaaag    12300

ttattaactt gggagtttac atgcacagct cccagtggtt tgagcccttt ctgttttggt    12360

ttacagtcaa gactgagatg aggtcagtga ttaaatcaca aacccatact tgccatagga    12420

ggagacacac acctgtattc ttcactggta gttcagttga gttgctaatc tctcgtgacc    12480

ttgttgctat aatcagtaaa gagtctcaac atgtatatta cctgacattt gaactggttt    12540

tgatgtattg tgatgtcata gaggggaggt taatgacaga gaccgctatg actattgatg    12600

ctaggtatac agagcttcta ggaagagtca gatacatgtg gaaactgata gatggtttct    12660

tccctgcact cgggaatcca acttatcaaa ttgtagccat gctggagcct ctttcacttg    12720

cttacctgca gctgagggat ataacagtag aactcagagg tgctttcctt aaccactgct    12780

ttactgaaat acatgatgtt cttgaccaaa acgggttttc tgatgaaggt acttatcatg    12840

agttaactga agctctagat tacattttca taactgatga catacatctg acaggggaga    12900

ttttctcatt tttcagaagt ttcggccacc ccagacttga agcagtaacg gctgctgaaa    12960

atgttaggaa atacatgaat cagcctaaag tcattgtgta tgagactctg atgaaaggtc    13020

atgccatatt ttgtggaatc ataatcaacg gctatcgtga caggcacgga ggcagttggc    13080

caccgctgac cctccccctg catgctgcag acacaatccg gaatgctcaa gcttcaggtg    13140

aagggttaac acatgagcag tgcgttgata actggaaatc ttttgctgga gtgaaatttg    13200

gctgctttat gcctcttagc ctggatagtg atctgacaat gtacctaaag gacaaggcac    13260

ttgctgctct ccaaagggaa tgggattcag tttacccgaa agagttcctg cgttacgacc    13320

ctcccaaggg aaccgggtca cggaggcttg tagatgtttt ccttaatgat tcgagctttg    13380

acccatatga tgtgataatg tatgttgtaa gtggagctta cctccatgac cctgagttca    13440

acctgtctta cagcctgaaa gaaaaggaga tcaaggaaac aggtagactt tttgctaaaa    13500

tgacttacaa aatgagggca tgccaagtga ttgctgaaaa tctaatctca aacgggattg    13560

gcaaatattt taaggacaat gggatggcca aggatgagca cgatttgact aaggcactcc    13620

acactctagc tgtctcagga gtccccaaag atctcaaaga aagtcacagg ggggggccag    13680

tcttaaaaac ctactcccga agcccagtcc acacaagtac caggaacgtg agagcagcaa    13740

aagggtttat agggttccct caagtaattc ggcaggacca agacactgat catccggaga    13800

atatggaagc ttacgagaca gtcagtgcat ttatcacgac tgatctcaag aagtactgcc    13860

ttaattggag atatgagacc atcagcttgt ttgcacagag gctaaatgag atttacggat    13920

tgccctcatt tttccagtgg ctgcataaga ggcttgagac ctctgtcctg tatgtaagtg    13980

accctcattg cccccccgac cttgacgccc atatcccgtt atataaagtc cccaatgatc    14040

aaatcttcat taagtaccct atgggaggta tagaagggta ttgtcagaag ctgtggacca    14100

tcagcaccat tccctatcta tacctggctg cttatgagag cggagtaagg attgcttcgt    14160

tagtgcaagg ggacaatcag accatagccg taacaaaaag ggtacccagc acatggccct    14220

acaaccttaa gaaacgggaa gctgctagag taactagaga ttactttgta attcttaggc    14280

aaaggctaca tgatattggc catcacctca aggcaaatga gacaattgtt tcatcacatt    14340

tttttgtcta ttcaaaagga atatattatg atgggctact tgtgtcccaa tcactcaaga    14400

gcatcgcaag atgtgtattc tggtcagaga ctatagttga tgaaacaagg gcagcatgca    14460

gtaatattgc tacaacaatg gctaaaagca tcgagagagg ttatgaccgt taccttgcat    14520

attccctgaa cgtcctaaaa gtgatacagc aaattctgat ctctcttggc ttcacaatca    14580

attcaaccat gacccgggat gtagtcatac ccctcctcac aaacaacgac ctcttaataa    14640

ggatggcact gttgcccgct cctattgggg ggatgaatta tctgaatatg agcaggctgt    14700

ttgtcagaaa catcggtgat ccagtaacat catcaattgc tgatctcaag agaatgattc    14760

tcgcctcact aatgcctgaa gagaccctcc atcaagtaat gacacaacaa ccgggggact    14820

cttcattcct agactgggct agcgaccctt actcagcaaa tcttgtatgt gtccagagca    14880

tcactagact cctcaagaac ataactgcaa ggtttgtcct gatccatagt ccaaacccaa    14940

tgttaaaagg attattccat gatgacagta aagaagagga cgagggactg gcggcattcc    15000

tcatggacag gcatattata gtacctaggg cagctcatga aatcctggat catagtgtca    15060

caggggcaag agagtctatt gcaggcatgc tggataccac aaaaggcttg attcgagcca    15120

gcatgaggaa gggggggtta acctctcgag tgataaccag attgtccaat tatgactatg    15180

aacaattcag agcagggatg gtgctattga caggaagaaa gagaaatgtc ctcattgaca    15240

aagagtcatg ttcagtgcag ctggcgagag ctctaagaag ccatatgtgg gcgaggctag    15300

ctcgaggacg gcctatttac ggccttgagg tccctgatgt actagaatct atgcgaggcc    15360

accttattcg gcgtcatgag acatgtgtca tctgcgagtg tggatcagtc aactacggat    15420

ggttttttgt cccctcgggt tgccaactgg atgatattga caaggaaaca tcatccttga    15480

gagtcccata tattggttct accactgatg agagaacaga catgaagctt gccttcgtaa    15540

gagccccaag tcgatccttg cgatctgctg ttagaatagc aacagtgtac tcatgggctt    15600

acggtgatga tgatagctct tggaacgaag cctggttgtt ggctaggcaa agggccaatg    15660

tgagcctgga ggagctaagg gtgatcactc ccatctcaac ttcgactaat ttagcgcata    15720

ggttgaggga tcgtagcact caagtgaaat actcaggtac atcccttgtc cgagtggcga    15780

ggtataccac aatctccaac gacaatctct catttgtcat atcagataag aaggttgata    15840

ctaactttat ataccaacaa ggaatgcttc tagggttggg tgttttagaa acattgtttc    15900

gactcgagaa agataccgga tcatctaaca cggtattaca tcttcacgtc gaaacagatt    15960

gttgcgtgat cccgatgata gatcatccca ggatacccag ctcccgcaag ctagagctga    16020

gggcagagct atgtaccaac ccattgatat atgataatgc acctttaatt gacagagatg    16080

caacaaggct atacacccag agccatagga ggcaccttgt ggaatttgtt acatggtcca    16140

caccccaact atatcacatt ttagctaagt ccacagcact atctatgatt gacctggtaa    16200

caaaatttga gaaggaccat atgaatgaaa tttcagctct cataggggat gacgatatca    16260

atagtttcat aactgagttt ctgctcatag agccaagatt attcactatc tacttgggcc    16320

agtgtgcggc catcaattgg gcatttgatg tacattatca tagaccatca gggaaatatc    16380

agatgggtga gctgttgtca tcgttccttt ctagaatgag caaaggagtg tttaaggtgc    16440

ttgtcaatgc tctaagccac ccaaagatct acaagaaatt ctggcattgt ggtattatag    16500

agcctatcca tggtccttca cttgatgctc aaaacttgca cacaactgtg tgcaacatgg    16560

tttacacatg ctatatgacc tacctcgacc tgttgttgaa tgaagagtta gaagagttca    16620

catttctctt gtgtgaaagc gacgaggatg tagtaccgga cagattcgac aacatccagg    16680

caaaacactt atgtgttctg gcagatttgt actgtcaacc agggacctgc ccaccaattc    16740

gaggtctaag accggtagag aaatgtgcag ttctaaccga ccatatcaag gcagaggcta    16800

tgttatctcc agcaggatct tcgtggaaca taaatccaat tattgtagac cattactcat    16860

gctctctgac ttatctccgg cgaggatcga tcaaacagat aagattgaga gttgatccag    16920

gattcatttt cgacgccctc gctgaggtaa atgtcagtca gccaaagatc ggcagcaaca    16980

acatctcaaa tatgagcatc aaggctttca gacccccaca cgatgatgtt gcaaaattgc    17040

tcaaagatat caacacaagc aagcacaatc ttcccatttc agggggcaat ctcgccaatt    17100

atgaaatcca tgctttccgc agaatcgggt tgaactcatc tgcttgctac aaagctgttg    17160

agatatcaac attaattagg agatgccttg agccagggga ggacggcttg ttcttgggtg    17220

agggatcggg ttctatgttg atcacttata aagagatact taaactaaac aagtgcttct    17280

ataatagtgg ggtttccgcc aattctagat ctggtcaaag ggaattagca ccctatccct    17340

ccgaagttgg ccttgtcgaa cacagaatgg gagtaggtaa tattgtcaaa gtgctcttta    17400

acgggaggcc cgaagtcacg tgggtaggca gtgtagattg cttcaatttc atagttagta    17460

atatccctac ctctagtgtg gggtttatcc attcagatat agagaccttg cctgacaaag    17520

atactataga gaagctagag gaattggcag ccatcttatc gatggctctg ctcctgggca    17580

aaataggatc aatactggtg attaagctta tgcctttcag cggggatttt gttcagggat    17640

ttataagtta tgtagggtct cattatagag aagtgaacct tgtataccct agatacagca    17700

acttcatctc tactgaatct tatttggtta tgacagatct caaggctaac cggctaatga    17760

atcctgaaaa gattaagcag cagataattg aatcatctgt gaggacttca cctggactta    17820

taggtcacat cctatccatt aagcaactaa gctgcataca agcaattgtg ggagacgcag    17880

ttagtagagg tgatatcaat cctactctga aaaaacttac acctatagag caggtgctga    17940

tcaattgcgg gttggcaatt aacggaccta agctgtgcaa agaattgatc caccatgatg    18000

ttgcctcagg gcaagatgga ttgcttaatt ctatactcat cctctacagg gagttggcaa    18060

gattcaaaga caaccaaaga agtcaacaag ggatgttcca cgcttacccc gtattggtaa    18120

gtagcaggca acgagaactt atatctagga tcacccgcaa attctggggg cacattcttc    18180

tttactccgg gaacaaaaag ttgataaata agtttatcca gaatctcaag tccggctatc    18240

tgatactaga cttacaccag aatatcttcg ttaagaatct atccaagtca gagaaacaga    18300

ttattatgac ggggggtttg aaacgtgagt gggtttttaa ggtaacagtc aaggagacca    18360

aagaatggta taagttagtc ggatacagtg ccctgattaa ggactaattg gttgaactcc    18420

ggaaccctaa tcctgcccta ggtggttagg cattatttgc aatatattaa agaaaacttt    18480

gaaaatacga agtttctatt cccagctttg tctggt                              18516


<210>  11
<211>  540
<212>  PRT
<213>  Norovirus

<400>  11

Met Lys Met Ala Ser Asn Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Ser Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Ile Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Thr 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Ser Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Asp Phe Ser Pro Lys Leu Gly Arg Val Gln Phe Ala 
        355                 360                 365             


Thr Asp Thr Asp Asn Asp Phe Asp Thr Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Gly Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Ser Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Val 
    530                 535                 540 


<210>  12
<211>  268
<212>  PRT
<213>  Norovirus

<400>  12

Met Ala Gly Ala Phe Phe Ala Gly Leu Ala Ser Asp Val Leu Ser Ser 
1               5                   10                  15      


Gly Leu Gly Ser Leu Ile Asn Ala Gly Ala Gly Ala Ile Asn Gln Thr 
            20                  25                  30          


Val Glu Phe Glu Asn Asn Arg Lys Leu Gln Gln Ala Ser Phe Gln Phe 
        35                  40                  45              


Ser Ser Asn Leu Gln Gln Ala Ser Phe Gln His Asp Lys Glu Met Leu 
    50                  55                  60                  


Gln Ser Gln Ile Asp Ala Thr Lys Lys Leu Gln Gln Glu Met Met Arg 
65                  70                  75                  80  


Val Lys Gln Ala Met Leu Leu Glu Gly Gly Phe Ser Glu Thr Asp Ala 
                85                  90                  95      


Ala Arg Gly Ala Ile Asn Ala Pro Met Thr Lys Val Leu Asp Trp Ser 
            100                 105                 110         


Gly Thr Arg Tyr Trp Ala Pro Asp Ala Arg Thr Thr Thr Tyr Asn Ala 
        115                 120                 125             


Gly Arg Phe Ser Thr Pro Gln Ser Ser Gly Ala Pro Pro Gly Arg Ala 
    130                 135                 140                 


Asn Leu Arg Ala Ala Val Pro Ala Gln Gly Ser Ser Ser Thr Ser Ser 
145                 150                 155                 160 


Asn Ser Ser Ile Ala Thr Ser Met Tyr Ser Asn Gln Thr Thr Ser Thr 
                165                 170                 175     


Arg Leu Gly Ser Thr Ala Gly Ser Gly Thr Ser Val Ser Ser Leu Pro 
            180                 185                 190         


Ser Ser Ala Arg Thr Arg Ser Trp Val Glu Asp Gln Asn Arg Asn Leu 
        195                 200                 205             


Ser Pro Phe Met Arg Gly Ala His Asn Ile Ser Phe Val Thr Pro Pro 
    210                 215                 220                 


Ser Ser Arg Ser Ser Ser Gln Gly Thr Val Ser Thr Val Pro Lys Glu 
225                 230                 235                 240 


Val Leu Asp Ser Trp Thr Gly Ala Phe Asn Thr Arg Arg Gln Pro Leu 
                245                 250                 255     


Phe Ala His Ile Arg Arg Arg Gly Glu Ser Arg Val 
            260                 265             


<210>  13
<211>  540
<212>  PRT
<213>  Norovirus

<400>  13

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Val Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Pro Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Ser Asn Tyr Asp Pro Thr Glu Glu Thr Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly Arg Val Gln Phe Glu 
        355                 360                 365             


Thr Asp Thr Asp Arg Asp Phe Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Ser Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr Pro Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 540 


<210>  14
<211>  268
<212>  PRT
<213>  Norovirus

<400>  14

Met Ala Gly Ala Phe Phe Ala Gly Leu Ala Ser Asp Val Leu Gly Ser 
1               5                   10                  15      


Gly Leu Gly Ser Leu Ile Asn Ala Gly Ala Gly Ala Ile Asn Gln Lys 
            20                  25                  30          


Val Glu Phe Glu Asn Asn Arg Lys Leu Gln Gln Ala Ser Phe Gln Phe 
        35                  40                  45              


Ser Ser Asn Leu Gln Gln Ala Ser Phe Gln His Asp Lys Glu Met Leu 
    50                  55                  60                  


Gln Ala Gln Ile Glu Ala Thr Lys Arg Leu Gln Gln Glu Met Met Lys 
65                  70                  75                  80  


Val Lys Gln Ala Met Leu Leu Glu Gly Gly Phe Ser Glu Thr Asp Ala 
                85                  90                  95      


Ala Arg Gly Ala Ile Asn Ala Pro Met Thr Lys Ala Leu Asp Trp Ser 
            100                 105                 110         


Gly Thr Arg Tyr Trp Ala Pro Asp Ala Arg Thr Thr Thr Tyr Asn Ala 
        115                 120                 125             


Gly Arg Phe Ser Thr Pro Gln Pro Ser Gly Ala Leu Pro Gly Arg Ala 
    130                 135                 140                 


Asn Leu Arg Asp Ala Val Pro Ala Arg Gly Ser Ser Ser Lys Ser Ser 
145                 150                 155                 160 


Asn Ser Ser Thr Ala Thr Ser Val Tyr Ser Asn Gln Thr Thr Ser Thr 
                165                 170                 175     


Arg Leu Gly Ser Thr Ala Gly Ser Gly Thr Ser Val Ser Ser Phe Pro 
            180                 185                 190         


Ser Thr Ala Arg Thr Arg Ser Trp Val Glu Asp Gln Ser Arg Asn Leu 
        195                 200                 205             


Ser Pro Phe Met Arg Gly Ala His Asn Ile Ser Phe Val Thr Pro Pro 
    210                 215                 220                 


Ser Ser Arg Ser Ser Ser Gln Gly Thr Val Ser Thr Val Pro Lys Glu 
225                 230                 235                 240 


Ile Leu Asp Ser Trp Thr Gly Ala Phe Asn Thr Arg Arg Gln Pro Leu 
                245                 250                 255     


Phe Ala His Ile Arg Lys Arg Gly Glu Ser Arg Ala 
            260                 265             


<210>  15
<211>  540
<212>  PRT
<213>  Norovirus

<400>  15

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Ser Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Val Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Pro Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Ser Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Asn Phe Ala Pro Lys Leu Gly Arg Val Gln Phe Glu 
        355                 360                 365             


Thr Asp Thr Asp His Asp Phe Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Ser Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr Pro Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 540 


<210>  16
<211>  268
<212>  PRT
<213>  Norovirus

<400>  16

Met Ala Gly Ala Phe Phe Ala Gly Leu Ala Ser Asp Val Leu Gly Ser 
1               5                   10                  15      


Gly Leu Gly Ser Leu Ile Asn Ala Gly Ala Gly Ala Ile Asn Gln Lys 
            20                  25                  30          


Val Glu Phe Glu Asn Asn Arg Lys Leu Gln Gln Ala Ser Phe Gln Phe 
        35                  40                  45              


Ser Ser Asn Leu Gln Gln Ala Ser Phe Gln His Asp Lys Glu Met Leu 
    50                  55                  60                  


Gln Ala Gln Ile Glu Ala Thr Lys Arg Leu Gln Gln Glu Met Met Lys 
65                  70                  75                  80  


Val Lys Gln Ala Met Leu Leu Glu Gly Gly Phe Ser Glu Thr Asp Ala 
                85                  90                  95      


Ala Arg Gly Ala Ile Asn Ala Pro Met Thr Lys Ala Leu Asp Trp Ser 
            100                 105                 110         


Gly Thr Arg Tyr Trp Ala Pro Asp Ala Arg Thr Thr Thr Tyr Asn Ala 
        115                 120                 125             


Gly Arg Phe Ser Thr Pro Gln Pro Ser Gly Ala Leu Leu Gly Arg Ala 
    130                 135                 140                 


Asn Leu Arg Asp Ala Val Pro Ala Arg Gly Ser Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Asn Ser Ser Thr Ala Thr Ser Val Tyr Ser Asn Gln Thr Thr Ser Thr 
                165                 170                 175     


Arg Leu Gly Ser Thr Ala Gly Ser Gly Thr Ser Val Ser Ser Phe Pro 
            180                 185                 190         


Ser Thr Ala Arg Thr Arg Ser Trp Val Glu Asp Gln Ser Arg Asn Leu 
        195                 200                 205             


Ser Pro Phe Met Arg Gly Ala His Asn Ile Ser Phe Val Thr Pro Pro 
    210                 215                 220                 


Ser Ser Arg Ser Ser Ser Gln Gly Thr Val Ser Thr Val Pro Lys Glu 
225                 230                 235                 240 


Ile Leu Asp Ser Trp Thr Gly Ala Phe Asn Thr Arg Arg Gln Pro Leu 
                245                 250                 255     


Phe Ala His Ile Arg Lys Arg Gly Glu Ser Arg Ala 
            260                 265             


<210>  17
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ATU

<400>  17
tagcctaccc tccatcattg ttataaaaaa cttaggaacc aggtccacac agccgccagc       60

ccatcaac                                                                68


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ATU

<400>  18
agcgcttaga cgtctcgcga tcgat                                             25


