                         SEQUENCE LISTING

<110>  INNATE PHARMA
 
<120>  LEUCOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR NEUTRALIZING ANTIBODIES

<130>  LILRB1

<150>  62/784,862
<151>  2018-12-26

<160>  213   

<170>  PatentIn version 3.5

<210>  1
<211>  650
<212>  PRT
<213>  homo sapiens

<400>  1

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Leu Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Ile Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
545                 550                 555                 560 


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
                565                 570                 575     


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
            580                 585                 590         


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
        595                 600                 605             


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
    610                 615                 620                 


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
625                 630                 635                 640 


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                645                 650 


<210>  2
<211>  627
<212>  PRT
<213>  homo sapiens

<400>  2

Gly His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Thr Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly Gln Glu Thr 
            20                  25                  30          


Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Leu Trp Ile Thr 
        35                  40                  45              


Arg Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro Ile Pro Ser 
    50                  55                  60                  


Ile Thr Trp Glu His Ala Gly Arg Tyr Arg Cys Tyr Tyr Gly Ser Asp 
65                  70                  75                  80  


Thr Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu Val Val Thr 
                85                  90                  95      


Gly Ala Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val 
            100                 105                 110         


Asn Ser Gly Gly Asn Val Ile Leu Gln Cys Asp Ser Gln Val Ala Phe 
        115                 120                 125             


Asp Gly Phe Ser Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys 
    130                 135                 140                 


Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser 
145                 150                 155                 160 


Val Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg Cys Tyr Ala 
                165                 170                 175     


Tyr Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser Asp Leu Leu 
            180                 185                 190         


Glu Leu Leu Val Leu Gly Val Ser Lys Lys Pro Ser Leu Ser Val Gln 
        195                 200                 205             


Pro Gly Pro Ile Val Ala Pro Glu Glu Thr Leu Thr Leu Gln Cys Gly 
    210                 215                 220                 


Ser Asp Ala Gly Tyr Asn Arg Phe Val Leu Tyr Lys Asp Gly Glu Arg 
225                 230                 235                 240 


Asp Phe Leu Gln Leu Ala Gly Ala Gln Pro Gln Ala Gly Leu Ser Gln 
                245                 250                 255     


Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln Tyr 
            260                 265                 270         


Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser 
        275                 280                 285             


Asp Pro Leu Asp Ile Leu Ile Ala Gly Gln Phe Tyr Asp Arg Val Ser 
    290                 295                 300                 


Leu Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr 
305                 310                 315                 320 


Leu Leu Cys Gln Ser Gln Gly Trp Met Gln Thr Phe Leu Leu Thr Lys 
                325                 330                 335     


Glu Gly Ala Ala Asp Asp Pro Trp Arg Leu Arg Ser Thr Tyr Gln Ser 
            340                 345                 350         


Gln Lys Tyr Gln Ala Glu Phe Pro Met Gly Pro Val Thr Ser Ala His 
        355                 360                 365             


Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu 
    370                 375                 380                 


Leu Thr His Pro Ser Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser 
385                 390                 395                 400 


Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro 
                405                 410                 415     


Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu 
            420                 425                 430         


Gly Arg His Leu Gly Val Val Ile Gly Ile Leu Val Ala Val Ile Leu 
        435                 440                 445             


Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg Arg 
    450                 455                 460                 


Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His 
465                 470                 475                 480 


Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp 
                485                 490                 495     


Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala 
            500                 505                 510         


Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser 
        515                 520                 525             


Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His 
    530                 535                 540                 


Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly 
545                 550                 555                 560 


Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met 
                565                 570                 575     


Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala 
            580                 585                 590         


Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro 
        595                 600                 605             


Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu 
    610                 615                 620                 


Ala Ile His 
625         


<210>  3
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Ile Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Ser Leu Gln Ala 
            20                  25                  30          


Glu Glu Tyr His Leu Tyr Arg Glu Asn Lys Ser Ala Ser Trp Val Arg 
        35                  40                  45              


Arg Ile Gln Glu Pro Gly Lys Asn Gly Gln Phe Pro Ile Pro Ser Ile 
    50                  55                  60                  


Thr Trp Glu His Ala Gly Arg Tyr His Cys Gln Tyr Tyr Ser His Asn 
65                  70                  75                  80  


His Ser Ser Glu Tyr Ser Asp Pro Leu Glu Leu Val Val Thr Gly Ala 
                85                  90                  95      


Tyr Ser Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Val Val Thr Leu 
            100                 105                 110         


Gly Gly Asn Val Thr Leu Gln Cys Val Ser Gln Val Ala Phe Asp Gly 
        115                 120                 125             


Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Arg Leu Asn 
    130                 135                 140                 


Ser His Ser His Ala Arg Gly Trp Ser Trp Ala Ile Phe Ser Val Gly 
145                 150                 155                 160 


Pro Val Ser Pro Ser Arg Arg Trp Ser Tyr Arg Cys Tyr Ala Tyr Asp 
                165                 170                 175     


Ser Asn Ser Pro Tyr Val Trp Ser Leu Pro Ser Asp Leu Leu Glu Leu 
            180                 185                 190         


Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val Gln Pro Gly 
        195                 200                 205             


Pro Met Val Ala Pro Gly Glu Ser Leu Thr Leu Gln Cys Val Ser Asp 
    210                 215                 220                 


Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu Arg Asp Phe 
225                 230                 235                 240 


Leu Gln Arg Pro Gly Trp Gln Pro Gln Ala Gly Leu Ser Gln Ala Asn 
                245                 250                 255     


Phe Thr Leu Gly Pro Val Ser Pro Ser His Gly Gly Gln Tyr Arg Cys 
            260                 265                 270         


Tyr Ser Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser Asp Pro 
        275                 280                 285             


Leu Asp Ile Leu Ile Thr Gly Gln Phe Tyr Asp Arg Pro Ser Leu Ser 
    290                 295                 300                 


Val Gln Pro Val Pro Thr Val Ala Pro Gly Lys Asn Val Thr Leu Leu 
305                 310                 315                 320 


Cys Gln Ser Arg Gly Gln Phe His Thr Phe Leu Leu Thr Lys Glu Gly 
                325                 330                 335     


Ala Gly His Pro Pro Leu His Leu Arg Ser Glu His Gln Ala Gln Gln 
            340                 345                 350         


Asn Gln Ala Glu Phe Arg Met Gly Pro Val Thr Ser Ala His Val Gly 
        355                 360                 365             


Thr Tyr Arg Cys Tyr Ser Ser Leu Ser Ser Asn Pro Tyr Leu Leu Ser 
    370                 375                 380                 


Leu Pro Ser Asp Pro Leu Glu Leu Val Val Ser Ala Ser Leu Gly Gln 
385                 390                 395                 400 


His Pro Gln Asp Tyr Thr Val Glu Asn Leu Ile Arg Met Gly Val Ala 
                405                 410                 415     


Gly Leu Val Leu Val Val Leu Gly Ile Leu Leu Phe Glu Ala Gln His 
            420                 425                 430         


Ser Gln Arg 
        435 


<210>  4
<211>  419
<212>  PRT
<213>  homo sapiens

<400>  4

Gly Pro Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Ser Trp Gly Asn Ser Val Thr Ile Trp Cys Gln Gly Thr Leu Glu Ala 
            20                  25                  30          


Arg Glu Tyr Arg Leu Asp Lys Glu Glu Ser Pro Ala Pro Trp Asp Arg 
        35                  40                  45              


Gln Asn Pro Leu Glu Pro Lys Asn Lys Ala Arg Phe Ser Ile Pro Ser 
    50                  55                  60                  


Met Thr Glu Asp Tyr Ala Gly Arg Tyr Arg Cys Tyr Tyr Arg Ser Pro 
65                  70                  75                  80  


Val Gly Trp Ser Gln Pro Ser Asp Pro Leu Glu Leu Val Met Thr Gly 
                85                  90                  95      


Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Leu Val Thr 
            100                 105                 110         


Ser Gly Lys Ser Val Thr Leu Leu Cys Gln Ser Arg Ser Pro Met Asp 
        115                 120                 125             


Thr Phe Leu Leu Ile Lys Glu Arg Ala Ala His Pro Leu Leu His Leu 
    130                 135                 140                 


Arg Ser Glu His Gly Ala Gln Gln His Gln Ala Glu Phe Pro Met Ser 
145                 150                 155                 160 


Pro Val Thr Ser Val His Gly Gly Thr Tyr Arg Cys Phe Ser Ser His 
                165                 170                 175     


Gly Phe Ser His Tyr Leu Leu Ser His Pro Ser Asp Pro Leu Glu Leu 
            180                 185                 190         


Ile Val Ser Gly Ser Leu Glu Gly Pro Arg Pro Ser Pro Thr Arg Ser 
        195                 200                 205             


Val Ser Thr Ala Gly Pro Glu Asp Gln Pro Leu Met Pro Thr Gly Ser 
    210                 215                 220                 


Val Pro His Ser Gly Leu Arg Arg His Trp Glu Val Leu Ile Gly Val 
225                 230                 235                 240 


Leu Val Val Ser Ile Leu Leu Leu Ser Leu Leu Leu Phe Leu Leu Leu 
                245                 250                 255     


Gln His Trp Arg Gln Gly Lys His Arg Thr Leu Ala Gln Arg Gln Ala 
            260                 265                 270         


Asp Phe Gln Arg Pro Pro Gly Ala Ala Glu Pro Glu Pro Lys Asp Gly 
        275                 280                 285             


Gly Leu Gln Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Gly Glu Asn 
    290                 295                 300                 


Phe Cys Ala Ala Val Lys Asn Thr Gln Pro Glu Asp Gly Val Glu Met 
305                 310                 315                 320 


Asp Thr Arg Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
                325                 330                 335     


Ala Lys Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
            340                 345                 350         


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
        355                 360                 365             


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
    370                 375                 380                 


Asp Val Thr Tyr Ala Gln Leu His Ser Phe Thr Leu Arg Gln Lys Ala 
385                 390                 395                 400 


Thr Glu Pro Pro Pro Ser Gln Glu Gly Ala Ser Pro Ala Glu Pro Ser 
                405                 410                 415     


Val Tyr Ala 
            


<210>  5
<211>  574
<212>  PRT
<213>  homo sapiens

<400>  5

Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser Val Ile 
1               5                   10                  15      


Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu Glu Ala 
            20                  25                  30          


Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp Ile Thr 
        35                  40                  45              


Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile Pro Ser 
    50                  55                  60                  


Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser Arg 
65                  70                  75                  80  


Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met Thr Gly 
                85                  90                  95      


Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val Thr 
            100                 105                 110         


Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala Phe Gly 
        115                 120                 125             


Gly Phe Ile Leu Cys Lys Glu Gly Glu Glu Glu His Pro Gln Cys Leu 
    130                 135                 140                 


Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser Val 
145                 150                 155                 160 


Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr Gly Tyr 
                165                 170                 175     


Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu Leu Glu 
            180                 185                 190         


Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val Gln Pro 
        195                 200                 205             


Gly Pro Val Val Ala Pro Gly Glu Ser Leu Thr Leu Gln Cys Val Ser 
    210                 215                 220                 


Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu Arg Asp 
225                 230                 235                 240 


Leu Arg Gln Leu Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser Gln Ala 
                245                 250                 255     


Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln Tyr Arg 
            260                 265                 270         


Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Cys Ser Ala Pro Ser Asp 
        275                 280                 285             


Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Gly Thr Pro Phe Ile 
    290                 295                 300                 


Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr Leu 
305                 310                 315                 320 


Leu Cys Gln Ser Trp Arg Gln Phe His Thr Phe Leu Leu Thr Lys Ala 
                325                 330                 335     


Gly Ala Ala Asp Ala Pro Leu Arg Leu Arg Ser Ile His Glu Tyr Pro 
            340                 345                 350         


Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala His Ala 
        355                 360                 365             


Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Asn Ser Asp Pro Tyr Leu Leu 
    370                 375                 380                 


Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly Pro Ser Met 
385                 390                 395                 400 


Gly Ser Ser Pro Pro Pro Thr Gly Pro Ile Ser Thr Pro Gly Pro Glu 
                405                 410                 415     


Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly 
            420                 425                 430         


Arg His Leu Gly Val Val Ile Gly Ile Leu Val Ala Val Val Leu Leu 
        435                 440                 445             


Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln 
    450                 455                 460                 


Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro 
465                 470                 475                 480 


Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg 
                485                 490                 495     


Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val 
            500                 505                 510         


Lys Asp Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ala Ala 
        515                 520                 525             


Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu 
    530                 535                 540                 


Thr Leu Arg Arg Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu Arg Glu 
545                 550                 555                 560 


Pro Pro Ala Glu Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                565                 570                 


<210>  6
<211>  603
<212>  PRT
<213>  homo sapiens

<400>  6

Gly Pro Phe Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Ser Trp Gly Ser Pro Val Thr Ile Trp Cys Gln Gly Ser Leu Glu Ala 
            20                  25                  30          


Gln Glu Tyr Arg Leu Asp Lys Glu Gly Ser Pro Glu Pro Leu Asp Arg 
        35                  40                  45              


Asn Asn Pro Leu Glu Pro Lys Asn Lys Ala Arg Phe Ser Ile Pro Ser 
    50                  55                  60                  


Met Thr Glu His His Ala Gly Arg Tyr Arg Cys His Tyr Tyr Ser Ser 
65                  70                  75                  80  


Ala Gly Trp Ser Glu Pro Ser Asp Pro Leu Glu Leu Val Met Thr Gly 
                85                  90                  95      


Phe Tyr Asn Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Val Val Ala 
            100                 105                 110         


Ser Gly Gly Asn Met Thr Leu Arg Cys Gly Ser Gln Lys Gly Tyr His 
        115                 120                 125             


His Phe Val Leu Met Lys Glu Gly Glu His Gln Leu Pro Arg Thr Leu 
    130                 135                 140                 


Asp Ser Gln Gln Leu His Ser Gly Gly Phe Gln Ala Leu Phe Pro Val 
145                 150                 155                 160 


Gly Pro Val Asn Pro Ser His Arg Trp Arg Phe Thr Cys Tyr Tyr Tyr 
                165                 170                 175     


Tyr Met Asn Thr Pro Gln Val Trp Ser His Pro Ser Asp Pro Leu Glu 
            180                 185                 190         


Ile Leu Pro Ser Gly Val Ser Arg Lys Pro Ser Leu Leu Thr Leu Gln 
        195                 200                 205             


Gly Pro Val Leu Ala Pro Gly Gln Ser Leu Thr Leu Gln Cys Gly Ser 
    210                 215                 220                 


Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu Arg Asp 
225                 230                 235                 240 


Phe Leu Gln Arg Pro Gly Gln Gln Pro Gln Ala Gly Leu Ser Gln Ala 
                245                 250                 255     


Asn Phe Thr Leu Gly Pro Val Ser Pro Ser His Gly Gly Gln Tyr Arg 
            260                 265                 270         


Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser Asp 
        275                 280                 285             


Pro Leu Asn Ile Leu Met Ala Gly Gln Ile Tyr Asp Thr Val Ser Leu 
    290                 295                 300                 


Ser Ala Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr Leu 
305                 310                 315                 320 


Leu Cys Gln Ser Trp Trp Gln Phe Asp Thr Phe Leu Leu Thr Lys Glu 
                325                 330                 335     


Gly Ala Ala His Pro Pro Leu Arg Leu Arg Ser Met Tyr Gly Ala His 
            340                 345                 350         


Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala His Ala 
        355                 360                 365             


Gly Thr Tyr Arg Cys Tyr Gly Ser Tyr Ser Ser Asn Pro His Leu Leu 
    370                 375                 380                 


Ser His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly His Ser Gly 
385                 390                 395                 400 


Gly Ser Ser Leu Pro Pro Thr Gly Pro Pro Ser Thr Pro Gly Leu Gly 
                405                 410                 415     


Arg Tyr Leu Glu Val Leu Ile Gly Val Ser Val Ala Phe Val Leu Leu 
            420                 425                 430         


Leu Phe Leu Leu Leu Phe Leu Leu Leu Arg Arg Gln Arg His Ser Lys 
        435                 440                 445             


His Arg Thr Ser Asp Gln Arg Lys Thr Asp Phe Gln Arg Pro Ala Gly 
    450                 455                 460                 


Ala Ala Glu Thr Glu Pro Lys Asp Arg Gly Leu Leu Arg Arg Ser Ser 
465                 470                 475                 480 


Pro Ala Ala Asp Val Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys Asp 
                485                 490                 495     


Thr Gln Ser Glu Asp Arg Val Glu Leu Asp Ser Gln Ser Pro His Asp 
            500                 505                 510         


Glu Asp Pro Gln Ala Val Thr Tyr Ala Pro Val Lys His Ser Ser Pro 
        515                 520                 525             


Arg Arg Glu Met Ala Ser Pro Pro Ser Ser Leu Ser Gly Glu Phe Leu 
    530                 535                 540                 


Asp Thr Lys Asp Arg Gln Val Glu Glu Asp Arg Gln Met Asp Thr Glu 
545                 550                 555                 560 


Ala Ala Ala Ser Glu Ala Ser Gln Asp Val Thr Tyr Ala Gln Leu His 
                565                 570                 575     


Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu Pro Pro Pro Ser Gln Glu 
            580                 585                 590         


Gly Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala 
        595                 600             


<210>  7
<211>  411
<212>  PRT
<213>  homo sapiens

<400>  7

Gly Pro Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Thr Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Ser Leu Glu Thr 
            20                  25                  30          


Gln Glu Tyr His Leu Tyr Arg Glu Lys Lys Thr Ala Leu Trp Ile Thr 
        35                  40                  45              


Arg Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro Ile Leu Ser 
    50                  55                  60                  


Ile Thr Trp Glu His Ala Gly Arg Tyr Cys Cys Ile Tyr Gly Ser His 
65                  70                  75                  80  


Thr Ala Gly Leu Ser Glu Ser Ser Asp Pro Leu Glu Leu Val Val Thr 
                85                  90                  95      


Gly Ala Tyr Ser Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Val Val 
            100                 105                 110         


Thr Ser Gly Gly Asn Val Thr Ile Gln Cys Asp Ser Gln Val Ala Phe 
        115                 120                 125             


Asp Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys 
    130                 135                 140                 


Leu Asn Ser His Ser His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser 
145                 150                 155                 160 


Val Gly Pro Val Ser Pro Ser Arg Arg Trp Ser Tyr Arg Cys Tyr Gly 
                165                 170                 175     


Tyr Asp Ser Arg Ala Pro Tyr Val Trp Ser Leu Pro Ser Asp Leu Leu 
            180                 185                 190         


Gly Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Leu Ser Val Gln 
        195                 200                 205             


Pro Gly Pro Val Val Ala Pro Gly Glu Lys Leu Thr Phe Gln Cys Gly 
    210                 215                 220                 


Ser Asp Ala Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Trp Gly Arg 
225                 230                 235                 240 


Asp Phe Leu Gln Arg Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser Gln 
                245                 250                 255     


Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln Tyr 
            260                 265                 270         


Thr Cys Ser Gly Ala Tyr Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser 
        275                 280                 285             


Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln Ile Arg Ala Arg Pro Phe 
    290                 295                 300                 


Leu Ser Val Arg Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr 
305                 310                 315                 320 


Leu Leu Cys Gln Ser Gln Gly Gly Met His Thr Phe Leu Leu Thr Lys 
                325                 330                 335     


Glu Gly Ala Ala Asp Ser Pro Leu Arg Leu Lys Ser Lys Arg Gln Ser 
            340                 345                 350         


His Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala His 
        355                 360                 365             


Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Leu Ser Ser Asn Pro Tyr Leu 
    370                 375                 380                 


Leu Thr His Pro Ser Asp Pro Leu Glu Leu Val Val Ser Gly Ala Ala 
385                 390                 395                 400 


Glu Thr Leu Ser Pro Pro Gln Asn Lys Ser Asp 
                405                 410     


<210>  8
<211>  471
<212>  PRT
<213>  homo sapiens

<400>  8

Glu Asn Leu Pro Lys Pro Ile Leu Trp Ala Glu Pro Gly Pro Val Ile 
1               5                   10                  15      


Thr Trp His Asn Pro Val Thr Ile Trp Cys Gln Gly Thr Leu Glu Ala 
            20                  25                  30          


Gln Gly Tyr Arg Leu Asp Lys Glu Gly Asn Ser Met Ser Arg His Ile 
        35                  40                  45              


Leu Lys Thr Leu Glu Ser Glu Asn Lys Val Lys Leu Ser Ile Pro Ser 
    50                  55                  60                  


Met Met Trp Glu His Ala Gly Arg Tyr His Cys Tyr Tyr Gln Ser Pro 
65                  70                  75                  80  


Ala Gly Trp Ser Glu Pro Ser Asp Pro Leu Glu Leu Val Val Thr Ala 
                85                  90                  95      


Tyr Ser Arg Pro Thr Leu Ser Ala Leu Pro Ser Pro Val Val Thr Ser 
            100                 105                 110         


Gly Val Asn Val Thr Leu Arg Cys Ala Ser Arg Leu Gly Leu Gly Arg 
        115                 120                 125             


Phe Thr Leu Ile Glu Glu Gly Asp His Arg Leu Ser Trp Thr Leu Asn 
    130                 135                 140                 


Ser His Gln His Asn His Gly Lys Phe Gln Ala Leu Phe Pro Met Gly 
145                 150                 155                 160 


Pro Leu Thr Phe Ser Asn Arg Gly Thr Phe Arg Cys Tyr Gly Tyr Glu 
                165                 170                 175     


Asn Asn Thr Pro Tyr Val Trp Ser Glu Pro Ser Asp Pro Leu Gln Leu 
            180                 185                 190         


Leu Val Ser Gly Val Ser Arg Lys Pro Ser Leu Leu Thr Leu Gln Gly 
        195                 200                 205             


Pro Val Val Thr Pro Gly Glu Asn Leu Thr Leu Gln Cys Gly Ser Asp 
    210                 215                 220                 


Val Gly Tyr Ile Arg Tyr Thr Leu Tyr Lys Glu Gly Ala Asp Gly Leu 
225                 230                 235                 240 


Pro Gln Arg Pro Gly Arg Gln Pro Gln Ala Gly Leu Ser Gln Ala Asn 
                245                 250                 255     


Phe Thr Leu Ser Pro Val Ser Arg Ser Tyr Gly Gly Gln Tyr Arg Cys 
            260                 265                 270         


Tyr Gly Ala His Asn Val Ser Ser Glu Trp Ser Ala Pro Ser Asp Pro 
        275                 280                 285             


Leu Asp Ile Leu Ile Ala Gly Gln Ile Ser Asp Arg Pro Ser Leu Ser 
    290                 295                 300                 


Val Gln Pro Gly Pro Thr Val Thr Ser Gly Glu Lys Val Thr Leu Leu 
305                 310                 315                 320 


Cys Gln Ser Trp Asp Pro Met Phe Thr Phe Leu Leu Thr Lys Glu Gly 
                325                 330                 335     


Ala Ala His Pro Pro Leu Arg Leu Arg Ser Met Tyr Gly Ala His Lys 
            340                 345                 350         


Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala His Ala Gly 
        355                 360                 365             


Thr Tyr Arg Cys Tyr Gly Ser Arg Ser Ser Asn Pro Tyr Leu Leu Ser 
    370                 375                 380                 


His Pro Ser Glu Pro Leu Glu Leu Val Val Ser Gly Ala Thr Glu Thr 
385                 390                 395                 400 


Leu Asn Pro Ala Gln Lys Lys Ser Asp Ser Lys Thr Ala Pro His Leu 
                405                 410                 415     


Gln Asp Tyr Thr Val Glu Asn Leu Ile Arg Met Gly Val Ala Gly Leu 
            420                 425                 430         


Val Leu Leu Phe Leu Gly Ile Leu Leu Phe Glu Ala Gln His Ser Gln 
        435                 440                 445             


Arg Ser Pro Pro Arg Cys Ser Gln Glu Ala Asn Ser Arg Lys Asp Asn 
    450                 455                 460                 


Ala Pro Phe Arg Val Val Glu 
465                 470     


<210>  9
<211>  437
<212>  PRT
<213>  homo sapiens

<400>  9

Gly Pro Phe Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Ser Trp Gly Ser Pro Val Thr Ile Trp Cys Gln Gly Ser Leu Glu Ala 
            20                  25                  30          


Gln Glu Tyr Gln Leu Asp Lys Glu Gly Ser Pro Glu Pro Leu Asp Arg 
        35                  40                  45              


Asn Asn Pro Leu Glu Pro Lys Asn Lys Ala Arg Phe Ser Ile Pro Ser 
    50                  55                  60                  


Met Thr Gln His His Ala Gly Arg Tyr Arg Cys His Tyr Tyr Ser Ser 
65                  70                  75                  80  


Ala Gly Trp Ser Glu Pro Ser Asp Pro Leu Glu Leu Val Met Thr Gly 
                85                  90                  95      


Phe Tyr Asn Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Val Val Ala 
            100                 105                 110         


Ser Gly Gly Asn Met Thr Leu Arg Cys Gly Ser Gln Lys Gly Tyr His 
        115                 120                 125             


His Phe Val Leu Met Lys Glu Gly Glu His Gln Leu Pro Arg Thr Leu 
    130                 135                 140                 


Asp Ser Gln Gln Leu His Ser Gly Gly Phe Gln Ala Leu Phe Pro Val 
145                 150                 155                 160 


Gly Pro Val Thr Pro Ser His Arg Trp Arg Phe Thr Cys Tyr Tyr Tyr 
                165                 170                 175     


Tyr Thr Asn Thr Pro Arg Val Trp Ser His Pro Ser Asp Pro Leu Glu 
            180                 185                 190         


Ile Leu Pro Ser Gly Val Ser Arg Lys Pro Ser Leu Leu Thr Leu Gln 
        195                 200                 205             


Gly Pro Val Leu Ala Pro Gly Gln Ser Leu Thr Leu Gln Cys Gly Ser 
    210                 215                 220                 


Asp Val Gly Tyr Asp Arg Phe Val Leu Tyr Lys Glu Gly Glu Arg Asp 
225                 230                 235                 240 


Phe Leu Gln Arg Pro Gly Gln Gln Pro Gln Ala Gly Leu Ser Gln Ala 
                245                 250                 255     


Asn Phe Thr Leu Gly Pro Val Ser Pro Ser His Gly Gly Gln Tyr Arg 
            260                 265                 270         


Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser Asp 
        275                 280                 285             


Pro Leu Asn Ile Leu Met Ala Gly Gln Ile Tyr Asp Thr Val Ser Leu 
    290                 295                 300                 


Ser Ala Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr Leu 
305                 310                 315                 320 


Leu Cys Gln Ser Arg Gly Tyr Phe Asp Thr Phe Leu Leu Thr Lys Glu 
                325                 330                 335     


Gly Ala Ala His Pro Pro Leu Arg Leu Arg Ser Met Tyr Gly Ala His 
            340                 345                 350         


Lys Tyr Gln Ala Glu Phe Pro Met Ser Pro Val Thr Ser Ala His Ala 
        355                 360                 365             


Gly Thr Tyr Arg Cys Tyr Gly Ser Tyr Ser Ser Asn Pro His Leu Leu 
    370                 375                 380                 


Ser Phe Pro Ser Glu Pro Leu Glu Leu Met Val Ser Ala Ser His Ala 
385                 390                 395                 400 


Lys Asp Tyr Thr Val Glu Asn Leu Ile Arg Met Gly Met Ala Gly Leu 
                405                 410                 415     


Val Leu Val Phe Leu Gly Ile Leu Leu Phe Glu Ala Gln His Ser Gln 
            420                 425                 430         


Arg Asn Pro Gln Asp 
        435         


<210>  10
<211>  338
<212>  PRT
<213>  homo sapiens

<400>  10

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  11
<211>  358
<212>  PRT
<213>  homo sapiens

<400>  11

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  12
<211>  117
<212>  PRT
<213>  mus musculus

<400>  12

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu His 
            20                  25                  30          


Thr Ile His Trp Ile Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe Tyr Pro Gly Ser Gly Ser Met Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Thr Asn Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  13
<211>  111
<212>  PRT
<213>  mus musculus

<400>  13

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Gly 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Leu Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ala Ala Met Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Glu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  14
<211>  5
<212>  PRT
<213>  mus musculus

<400>  14

Glu His Thr Ile His 
1               5   


<210>  15
<211>  17
<212>  PRT
<213>  mus musculus

<400>  15

Trp Phe Tyr Pro Gly Ser Gly Ser Met Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  16
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  16

His Thr Asn Trp Asp Phe Asp Tyr 
1               5               


<210>  17
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  17

Lys Ala Ser Gln Ser Val Asp Tyr Gly Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  18
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  18

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  19

Gln Gln Ser Asn Glu Glu Pro Trp Thr 
1               5                   


<210>  20
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  20

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Leu Tyr Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Thr Asn Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  21
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  21

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Gly 
            20                  25                  30          


Gly Ala Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Leu Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Met Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Glu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  22
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  22

Ala His Thr Ile His 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  23

Trp Leu Tyr Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  24
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  24

His Thr Asn Trp Asp Phe Asp Tyr 
1               5               


<210>  25
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  25

Lys Ala Ser Gln Ser Val Asp Tyr Gly Gly Ala Ser Tyr Met Asn 
1               5                   10                  15  


<210>  26
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  26

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  27

Gln Gln Ser Asn Glu Glu Pro Trp Thr 
1               5                   


<210>  28
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  28

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Ser Asp Ser Tyr Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Lys Thr Ala Tyr 
65                  70                  75                  80  


Ile His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Glu Arg Tyr Asp Gly Asp Tyr Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  29
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  29

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Asn Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  30
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  30

Ser Tyr Trp Val His 
1               5   


<210>  31
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  31

Val Ile Asp Pro Ser Asp Ser Tyr Thr Ser Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  32

Gly Glu Arg Tyr Asp Gly Asp Tyr Phe Ala Met Asp Tyr 
1               5                   10              


<210>  33
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  33

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  34
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  34

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  35

Gln His Phe Trp Asn Thr Pro Arg Thr 
1               5                   


<210>  36
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  36

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Pro Arg Trp Asp Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  37
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  37

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  38
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  38

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Glu Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Arg Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Asn Asn Arg Ile Ser Ile Thr Arg Asp Ala Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Leu Leu Trp Phe Tyr Ala Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  39
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  39

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Ser Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  40
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  40

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Asn Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Asn Trp Asp Gly Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  41
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  41

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Arg Ser Tyr Pro Leu 
                85                  90                  95      


Gly Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  42
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Homo sapiens with substitutions

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  43
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Homo sapiens with substitutions

<400>  43

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  44
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Homo sapiens with substitutions

<400>  44

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  45
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Homo sapiens with substitutions

<400>  45

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  46
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  46

Thr Gly Val His Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
1               5                   10                  15      


Asp Ser Thr Gly His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly 
            20                  25                  30          


Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly 
        35                  40                  45              


Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Leu 
    50                  55                  60                  


Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro 
65                  70                  75                  80  


Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr Arg Cys Tyr Tyr 
                85                  90                  95      


Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu 
            100                 105                 110         


Val Val Thr Gly Ala Gly Ala Leu Gln Ser Thr Ala Ser Leu Phe Val 
        115                 120                 125             


Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
    130                 135             


<210>  47
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  47

Thr Gly Val His Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
1               5                   10                  15      


Asp Ser Thr Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            20                  25                  30          


Val Asn Ser Gly Gly Asn Val Ile Leu Gln Cys Asp Ser Gln Val Ala 
        35                  40                  45              


Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln 
    50                  55                  60                  


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
65                  70                  75                  80  


Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg Cys Tyr 
                85                  90                  95      


Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser Asp Leu 
            100                 105                 110         


Leu Glu Leu Leu Val Leu Gly Val Gly Ala Leu Gln Ser Thr Ala Ser 
        115                 120                 125             


Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
    130                 135                 140     


<210>  48
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  48

Thr Gly Val His Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
1               5                   10                  15      


Asp Ser Thr Ser Lys Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile 
            20                  25                  30          


Val Ala Pro Glu Glu Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly 
        35                  40                  45              


Tyr Asn Arg Phe Val Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln 
    50                  55                  60                  


Leu Ala Gly Ala Gln Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr 
65                  70                  75                  80  


Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly 
                85                  90                  95      


Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp 
            100                 105                 110         


Ile Leu Ile Ala Gly Gln Gly Ala Leu Gln Ser Thr Ala Ser Leu Phe 
        115                 120                 125             


Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
    130                 135                 


<210>  49
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  49

Thr Gly Val His Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
1               5                   10                  15      


Asp Ser Thr Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro 
            20                  25                  30          


Thr Val Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly 
        35                  40                  45              


Trp Met Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro 
    50                  55                  60                  


Trp Arg Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe 
65                  70                  75                  80  


Pro Met Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr 
                85                  90                  95      


Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr 
        115                 120                 125             


Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro 
    130                 135                 140                 


Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val 
145                 150                 155                 160 


Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu 
                165                 170                 175     


Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser 
            180                 185                 190         


Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro 
        195                 200                 205             


Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp 
    210                 215                 220                 


Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu 
225                 230                 235                 240 


Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln 
                245                 250                 255     


Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met 
            260                 265                 270         


Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp 
        275                 280                 285             


Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser 
    290                 295                 300                 


Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu 
305                 310                 315                 320 


Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro 
                325                 330                 335     


Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
            340                 345             


<210>  50
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  50

Thr Gly Val His Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
1               5                   10                  15      


Asp Ser Thr Gly His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly 
            20                  25                  30          


Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly 
        35                  40                  45              


Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Leu 
    50                  55                  60                  


Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro 
65                  70                  75                  80  


Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr Arg Cys Tyr Tyr 
                85                  90                  95      


Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu 
            100                 105                 110         


Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser 
        115                 120                 125             


Pro Val Val Asn Ser Gly Gly Asn Val Ile Leu Gln Cys Asp Ser Gln 
    130                 135                 140                 


Val Ala Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly Glu Asp Glu His 
145                 150                 155                 160 


Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala 
                165                 170                 175     


Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg 
            180                 185                 190         


Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser 
        195                 200                 205             


Asp Leu Leu Glu Leu Leu Val Leu Gly Val Gly Ala Leu Gln Ser Thr 
    210                 215                 220                 


Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
225                 230                 235                 


<210>  51
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  51

Thr Gly Val His Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
1               5                   10                  15      


Asp Ser Thr Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            20                  25                  30          


Val Asn Ser Gly Gly Asn Val Ile Leu Gln Cys Asp Ser Gln Val Ala 
        35                  40                  45              


Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln 
    50                  55                  60                  


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
65                  70                  75                  80  


Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg Cys Tyr 
                85                  90                  95      


Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser Asp Leu 
            100                 105                 110         


Leu Glu Leu Leu Val Leu Gly Val Ser Lys Lys Pro Ser Leu Ser Val 
        115                 120                 125             


Gln Pro Gly Pro Ile Val Ala Pro Glu Glu Thr Leu Thr Leu Gln Cys 
    130                 135                 140                 


Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val Leu Tyr Lys Asp Gly Glu 
145                 150                 155                 160 


Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln Pro Gln Ala Gly Leu Ser 
                165                 170                 175     


Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro 
        195                 200                 205             


Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Gln Gly Ala Leu Gln Ser 
    210                 215                 220                 


Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
225                 230                 235                 240 


<210>  52
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  52

Thr Gly Val His Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
1               5                   10                  15      


Asp Ser Thr Ser Lys Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile 
            20                  25                  30          


Val Ala Pro Glu Glu Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly 
        35                  40                  45              


Tyr Asn Arg Phe Val Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln 
    50                  55                  60                  


Leu Ala Gly Ala Gln Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr 
65                  70                  75                  80  


Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly 
                85                  90                  95      


Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp 
            100                 105                 110         


Ile Leu Ile Ala Gly Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln 
        115                 120                 125             


Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln 
    130                 135                 140                 


Ser Gln Gly Trp Met Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala 
145                 150                 155                 160 


Asp Asp Pro Trp Arg Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln 
                165                 170                 175     


Ala Glu Phe Pro Met Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr 
            180                 185                 190         


Arg Cys Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro 
        195                 200                 205             


Ser Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser 
    210                 215                 220                 


Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro 
225                 230                 235                 240 


Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu 
                245                 250                 255     


Gly Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu 
            260                 265                 270         


Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His 
        275                 280                 285             


Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala 
    290                 295                 300                 


Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro 
305                 310                 315                 320 


Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr 
                325                 330                 335     


Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu 
            340                 345                 350         


Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg 
        355                 360                 365             


Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp 
    370                 375                 380                 


Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala 
385                 390                 395                 400 


Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser 
                405                 410                 415     


Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly 
            420                 425                 430         


Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
        435                 440                 445         


<210>  53
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  53

Thr Gly Val His Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
1               5                   10                  15      


Asp Ser Thr Gly His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly 
            20                  25                  30          


Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly 
        35                  40                  45              


Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Leu 
    50                  55                  60                  


Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro 
65                  70                  75                  80  


Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr Arg Cys Tyr Tyr 
                85                  90                  95      


Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu 
            100                 105                 110         


Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser 
        115                 120                 125             


Pro Val Val Asn Ser Gly Gly Asn Val Ile Leu Gln Cys Asp Ser Gln 
    130                 135                 140                 


Val Ala Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly Glu Asp Glu His 
145                 150                 155                 160 


Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala 
                165                 170                 175     


Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg 
            180                 185                 190         


Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser 
        195                 200                 205             


Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys Lys Pro Ser Leu 
    210                 215                 220                 


Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu Thr Leu Thr Leu 
225                 230                 235                 240 


Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val Leu Tyr Lys Asp 
                245                 250                 255     


Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln Pro Gln Ala Gly 
            260                 265                 270         


Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly 
        275                 280                 285             


Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Trp Ser 
    290                 295                 300                 


Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Gln Gly Ala Leu 
305                 310                 315                 320 


Gln Ser Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu 
                325                 330                 335     


Tyr Ser 
        


<210>  54
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  54

Thr Gly Val His Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
1               5                   10                  15      


Asp Ser Thr Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
            20                  25                  30          


Val Asn Ser Gly Gly Asn Val Ile Leu Gln Cys Asp Ser Gln Val Ala 
        35                  40                  45              


Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln 
    50                  55                  60                  


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
65                  70                  75                  80  


Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg Cys Tyr 
                85                  90                  95      


Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser Asp Leu 
            100                 105                 110         


Leu Glu Leu Leu Val Leu Gly Val Ser Lys Lys Pro Ser Leu Ser Val 
        115                 120                 125             


Gln Pro Gly Pro Ile Val Ala Pro Glu Glu Thr Leu Thr Leu Gln Cys 
    130                 135                 140                 


Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val Leu Tyr Lys Asp Gly Glu 
145                 150                 155                 160 


Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln Pro Gln Ala Gly Leu Ser 
                165                 170                 175     


Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro 
        195                 200                 205             


Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly Gln Phe Tyr Asp Arg Val 
    210                 215                 220                 


Ser Leu Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Leu Cys Gln Ser Gln Gly Trp Met Gln Thr Phe Leu Leu Thr 
                245                 250                 255     


Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg Leu Arg Ser Thr Tyr Gln 
            260                 265                 270         


Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met Gly Pro Val Thr Ser Ala 
        275                 280                 285             


His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Gln Ser Ser Lys Pro Tyr 
    290                 295                 300                 


Leu Leu Thr His Pro Ser Asp Pro Leu Glu Leu Val Val Ser Gly Pro 
305                 310                 315                 320 


Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly 
                325                 330                 335     


Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly 
            340                 345                 350         


Leu Gly Arg His Leu Gly Val Val Ile Gly Ile Leu Val Ala Val Ile 
        355                 360                 365             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg 
    370                 375                 380                 


Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln 
385                 390                 395                 400 


His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln 
                405                 410                 415     


Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala 
            420                 425                 430         


Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg 
        435                 440                 445             


Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys 
    450                 455                 460                 


His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser 
465                 470                 475                 480 


Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln 
                485                 490                 495     


Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr 
            500                 505                 510         


Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro 
        515                 520                 525             


Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr 
    530                 535                 540                 


Leu Ala Ile His 
545             


<210>  55
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  55

Gly His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Thr Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly Gln Glu Thr 
            20                  25                  30          


Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Leu Trp Ile Thr 
        35                  40                  45              


Arg Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro Ile Pro Ser 
    50                  55                  60                  


Ile Thr Trp Glu His Ala Gly Arg Tyr Arg Cys Tyr Tyr Gly Ser Asp 
65                  70                  75                  80  


Thr Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu Val Val Thr 
                85                  90                  95      


Gly Ala 
        


<210>  56
<211>  137
<212>  PRT
<213>  homo sapiens

<400>  56

Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val Ala 
1               5                   10                  15      


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met Gln 
            20                  25                  30          


Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg Leu 
        35                  40                  45              


Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met Gly 
    50                  55                  60                  


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Gln 
65                  70                  75                  80  


Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu Leu 
                85                  90                  95      


Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
            100                 105                 110         


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
        115                 120                 125             


Asp Pro Gln Ser Gly Leu Gly Arg His 
    130                 135         


<210>  57
<211>  35
<212>  DNA
<213>  homo sapiens

<400>  57
acaggcgtgc attcggggca cctccccaag cccac                                  35


<210>  58
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  58
cgaggtcggg ggatcctcaa tggtggtgat gatggtggtg ccttcccaga ccactctg         58


<210>  59
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic

<400>  59

Gly His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Thr Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly Gln Glu Thr 
            20                  25                  30          


Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Leu Trp Ile Thr 
        35                  40                  45              


Arg Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro Ile Pro Ser 
    50                  55                  60                  


Ile Thr Trp Glu His Ala Gly Arg Tyr Arg Cys Tyr Tyr Gly Ser Asp 
65                  70                  75                  80  


Thr Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu Val Val Thr 
                85                  90                  95      


Gly Ala Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val 
            100                 105                 110         


Asn Ser Gly Gly Asn Val Ile Leu Gln Cys Asp Ser Gln Val Ala Phe 
        115                 120                 125             


Asp Gly Phe Ser Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys 
    130                 135                 140                 


Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser 
145                 150                 155                 160 


Val Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg Cys Tyr Ala 
                165                 170                 175     


Tyr Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser Asp Leu Leu 
            180                 185                 190         


Glu Leu Leu Val Leu Gly Val Ser Lys Lys Pro Ser Leu Ser Val Gln 
        195                 200                 205             


Pro Gly Pro Ile Val Ala Pro Glu Glu Thr Leu Thr Leu Gln Cys Gly 
    210                 215                 220                 


Ser Asp Ala Gly Tyr Asn Arg Phe Val Leu Tyr Lys Asp Gly Glu Arg 
225                 230                 235                 240 


Asp Phe Leu Gln Leu Ala Gly Ala Gln Pro Gln Ala Gly Leu Ser Gln 
                245                 250                 255     


Ala Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln Tyr 
            260                 265                 270         


Arg Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser 
        275                 280                 285             


Asp Pro Leu Asp Ile Leu Ile Ala Gly Gln Phe Tyr Asp Arg Val Ser 
    290                 295                 300                 


Leu Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr 
305                 310                 315                 320 


Leu Leu Cys Gln Ser Gln Gly Trp Met Gln Thr Phe Leu Leu Thr Lys 
                325                 330                 335     


Glu Gly Ala Ala Asp Asp Pro Trp Arg Leu Arg Ser Thr Tyr Gln Ser 
            340                 345                 350         


Gln Lys Tyr Gln Ala Glu Phe Pro Met Gly Pro Val Thr Ser Ala His 
        355                 360                 365             


Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu 
    370                 375                 380                 


Leu Thr His Pro Ser Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser 
385                 390                 395                 400 


Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro 
                405                 410                 415     


Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu 
            420                 425                 430         


Gly Arg His His His His His His His 
        435                 440     


<210>  60
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  60

Ala Cys Ala Gly Gly Cys Gly Thr Gly Cys Ala Thr Thr Cys Gly Gly 
1               5                   10                  15      


Gly Gly Cys Ala Cys Cys Thr Cys Cys Cys Cys Ala Ala Gly Cys Cys 
            20                  25                  30          


Cys 
    


<210>  61
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  61

Cys Cys Gly Cys Cys Cys Cys Gly Ala Cys Thr Cys Thr Ala Gly Ala 
1               5                   10                  15      


Cys Thr Ala Gly Thr Gly Gly Ala Thr Gly Gly Cys Cys Ala Gly Ala 
            20                  25                  30          


Gly Thr Gly Gly 
        35      


<210>  62
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  62

Cys Cys Ala Gly Ala Ala Cys Ala Cys Ala Gly Gly Ala Thr Cys Cys 
1               5                   10                  15      


Gly Cys Cys Gly Cys Cys Ala Cys Cys Ala Thr Gly Gly Thr Gly Gly 
            20                  25                  30          


Thr Cys Ala Thr Gly Gly Cys Gly Cys Cys Cys 
        35                  40              


<210>  63
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  63

Thr Thr Thr Thr Cys Thr Ala Gly Gly Thr Cys Thr Cys Gly Ala Gly 
1               5                   10                  15      


Thr Cys Ala Ala Thr Cys Thr Gly Ala Gly Cys Thr Cys Thr Thr Cys 
            20                  25                  30          


Thr Thr Thr Cys 
        35      


<210>  64
<211>  92
<212>  DNA
<213>  Homo sapiens

<400>  64
acaggcgtgc attcgggtaa gcctatccct aaccctctcc tcggtctcga ttctacgggg       60

cacctcccca agcccaccct ctgggctgag cc                                     92


<210>  65
<211>  92
<212>  DNA
<213>  Homo sapiens

<400>  65
acaggcgtgc attcgggtaa gcctatccct aaccctctcc tcggtctcga ttctacgggg       60

cacctcccca agcccaccct ctgggctgag cc                                     92


<210>  66
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  66
acaggcgtgc attcgggtaa gcctatccct aaccctctcc tcggtctcga ttctacgggg       60

cccctcccca aacccaccct ctgggctgag cca                                    93


<210>  67
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  67
acaggcgtgc attcgggtaa gcctatccct aaccctctcc tcggtctcga ttctacgggg       60

accatcccca agcccaccct gtgggctgag cca                                    93


<210>  68
<211>  92
<212>  DNA
<213>  Homo sapiens

<400>  68
acaggcgtgc attcgggtaa gcctatccct aaccctctcc tcggtctcga ttctacgggg       60

cccttcccca aacccaccct ctgggctgag cc                                     92


<210>  69
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  69
acaggcgtgc attcgggtaa gcctatccct aaccctctcc tcggtctcga ttctacgggg       60

cccctcccca aacccaccct ctgggctgag cca                                    93


<210>  70
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  70
acaggcgtgc attcgggtaa gcctatccct aaccctctcc tcggtctcga ttctacggaa       60

aacctaccca aacccatcct gtgggccgag cca                                    93


<210>  71
<211>  92
<212>  DNA
<213>  Homo sapiens

<400>  71
acaggcgtgc attcgggtaa gcctatccct aaccctctcc tcggtctcga ttctacgggg       60

cccttcccca aacccaccct ctgggctgag cc                                     92


<210>  72
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  72
ccgccccgac tctagatcat ctctggctgt gctgagc                                37


<210>  73
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  73
ccgccccgac tctagactag tggatggcca gagtgg                                 36


<210>  74
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  74
ccgccccgac tctagatcag gcatagacac tgggctc                                37


<210>  75
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  75
ccgccccgac tctagactag tggatggcca gggtgg                                 36


<210>  76
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  76
ccgccccgac tctagatcag gcgtagatgc tgggctc                                37


<210>  77
<211>  115
<212>  DNA
<213>  Homo sapiens

<400>  77
cgccccgact ctagatcaag agtaaagatg cagaagacta agactgacta caaataggga       60

agcagtagat tgaagagcac cctcaccagc cttggagtcg gacttgtttt gtggt           115


<210>  78
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  78
ccgccccgac tctagatcac tccaccactc tgaaggg                                37


<210>  79
<211>  37
<212>  DNA
<213>  homo sapiens

<400>  79
ccgccccgac tctagatcaa tcttgggggt ttctctg                                37


<210>  80
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic

<400>  80

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  81
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  81

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Phe 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  82
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  82

Gln Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Pro Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  83
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  83

Asp Val Gln Leu Val Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Gly Gly Glu Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  84
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Pro Ser Glu Asn Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Val 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  85
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  85

Glu Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Gly Glu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  86
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  86

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Ile Pro Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  87
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  87

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  88
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  88

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Asn Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Asp Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  89
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  89

Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  90
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  90

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Ile Pro Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  91
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  91

Glu Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Ser Ser Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  92
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  92

Asp Ile Leu Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Ile Pro Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  93
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  93

Glu Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  94
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  94

Asp Ile Leu Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Ile Pro Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  95
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  95

Gln Val Gln Leu Lys Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Ser 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  96
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  96

Asp Val Val Val Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  97
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  97

Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Phe 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Gly Glu Thr Asn Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Asn Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  98
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  98

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Val Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Arg Ala Ser Thr Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  99
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  99

Glu Val Lys Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Phe 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Gly Glu Thr Asn Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Asn Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  100
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  100

Glu Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Asp Gly Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Val Leu Ile Tyr Arg Ala Ser Ile Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  101
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  101

Asp Val Gln Leu Val Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Gly Gly Glu Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  102
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  102

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Asp Gly Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Tyr Arg Ala Ser Thr Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Ala Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  103
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  103

Asp Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ser Ser Gly Tyr Ser Phe Thr Asn Phe 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Thr Gly Glu Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Ala Leu Thr Ala Asp Thr Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Thr Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Ile Thr Val Ser Ser 
        115                 


<210>  104
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  104

Asp Val Val Met Thr Gln Thr Pro Ala Phe Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Met Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  105
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  105

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Arg Asn Tyr 
            20                  25                  30          


Tyr Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Tyr Glu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  106
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  106

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Phe 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Pro Asp Phe Ser Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Ala Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  107
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  107

Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  108
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  108

Glu Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  109
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  109

Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  110
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  110

Asp Ile Leu Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Gly Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  111
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  111

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  112
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  112

Glu Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Gly Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Tyr Arg Ala Ser Asn Leu Val Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  113
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  113

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Arg Asn Tyr 
            20                  25                  30          


Tyr Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Asn Glu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  114
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  114

Glu Ile Leu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Thr Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  115
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  115

Gln Val Gln Leu Lys Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Gly Glu Ala Ile Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  116
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  116

Glu Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ile Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  117
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  117

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  118
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  118

Gln Ile Val Leu Ser Gln Ser Pro Val Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Lys Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  119
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  119

Glu Val His Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Arg Ala Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  120
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  120

Glu Ile Leu Leu Thr Gln Ser Pro Pro Ala Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Gln Arg Val Thr Ile Ser Cys Arg Pro Ser Glu Asn Ile Asp Ser 
            20                  25                  30          


Tyr Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro 
    50                  55                  60                  


Val Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser 
                85                  90                  95      


Asn Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  121
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  121

Gln Val Gln Leu Lys Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Ser 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  122
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  122

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Pro Ser Glu Asn Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Cys Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Val 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  123
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  123

Gln Val Gln Leu Lys Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Leu Gly Ser Gly Glu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Glu Ala Ile Leu Thr Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  124
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  124

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Val Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Arg Ala Ser Thr Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  125
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  125

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Phe 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  126
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  126

Glu Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  127
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  127

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ser Ser Gly Tyr Ser Phe Thr Asn Phe 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Ala Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  128
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  128

Gln Ile Val Leu Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Pro Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  129
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  129

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ile Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Val 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Pro Asn Trp Asp Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  130
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  130

Asp Ala Val Met Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Ile Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Pro Asp Phe Ser Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  131
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  131

Asp Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ser Ser Gly Tyr Ser Phe Thr Asn Phe 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Thr Gly Glu Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Ala Leu Thr Ala Asp Thr Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Thr Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Ile Thr Val Ser Ser 
        115                 


<210>  132
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  132

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Val Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Ser Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Ile Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  133
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  133

Glu Val Lys Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Phe 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Gly Glu Thr Asn Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Asn Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  134
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  134

Asp Val Val Met Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Asp Gly Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Arg Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Tyr Arg Ala Ser Thr Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asn Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  135
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  135

Gln Arg Glu Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Asn Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn His 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Gly Asp Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  136
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  136

Asp Val Val Met Thr Gln Thr Pro Ala Phe Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Arg Thr Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  137
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  137

Gln Val Gln Leu Lys Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Asn Phe Arg Asn Tyr 
            20                  25                  30          


Tyr Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Asn Glu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Ala Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  138
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  138

Asp Val Val Met Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ile Ile Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Ser Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Gly Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  139
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  139

Asn Tyr Tyr Met Gln 
1               5   


<210>  140
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  140

Trp Ile Phe Pro Gly Ser Gly Glu Ser Ser Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  141

Thr Trp Asn Tyr Asp Ala Arg Trp Gly Tyr 
1               5                   10  


<210>  142
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  142

Ile Pro Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  143
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  143

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  144
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  144

Gln Gln Ser Asn Glu Asp Pro Phe Thr 
1               5                   


<210>  145
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  145

Asn Phe Tyr Ile His 
1               5   


<210>  146
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  146

Trp Ile Phe Pro Gly Ser Gly Glu Thr Lys Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Val 
    


<210>  147
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  147

Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr 
1               5                   10  


<210>  148
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  148

Arg Ala Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Leu His 
1               5                   10                  15  


<210>  149
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  149

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  150
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  150

Gln Gln Ser Asn Glu Asp Pro Phe Thr 
1               5                   


<210>  151
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  151

Asn Tyr Tyr Val Gln 
1               5   


<210>  152
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  152

Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  153
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  153

Gln Gln Thr Asn Glu Asp Pro Phe Thr 
1               5                   


<210>  154
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  154

Asn Tyr Tyr Met Gln 
1               5   


<210>  155
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  155

Trp Ile Phe Pro Gly Gly Gly Glu Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  156
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  156

Ile Pro Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  157
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  157

Asn Tyr Tyr Ile Gln 
1               5   


<210>  158
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  158

Trp Ile Phe Pro Gly Asn Gly Glu Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  159
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  159

Arg Ala Asn Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  160
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  160

Arg Ala Ser Asn Leu Asp Ser 
1               5           


<210>  161
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  161

Trp Ile Phe Pro Gly Ser Gly Glu Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  162
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  162

Ile Pro Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  163
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  163

Asn Tyr Tyr Ile His 
1               5   


<210>  164
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  164

Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Val 
    


<210>  165
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  165

Arg Ala Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  166
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  166

Trp Ile Phe Pro Gly Ser Gly Asp Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  167
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  167

Arg Val Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  168
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  168

Arg Ala Ser Thr Leu Glu Ser 
1               5           


<210>  169
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  169

Trp Ile Phe Pro Gly Asn Gly Glu Thr Asn Tyr Ser Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  170
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  170

Thr Trp Asn Tyr Asp Ala Arg Trp Val Tyr 
1               5                   10  


<210>  171
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  171

Arg Ala Ser Asp Gly Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  172
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  172

Arg Ala Ser Ile Leu Glu Ser 
1               5           


<210>  173
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  173

Trp Ile Phe Pro Gly Asn Gly Glu Thr Asn Tyr Ser Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  174
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  174

Arg Ala Ser Asp Gly Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  175
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  175

Gln Gln Thr Asn Glu Ala Pro Phe Thr 
1               5                   


<210>  176
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  176

Asn Tyr Tyr Ile Asn 
1               5   


<210>  177
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  177

Trp Ile Phe Pro Gly Asn Gly Asp Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  178
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  178

Arg Ala Ser Glu Ser Ile Asp Ser Tyr Met Ser 
1               5                   10      


<210>  179
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  179

Gly Ala Ser Asn Leu Glu Ser 
1               5           


<210>  180
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  180

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  181
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  181

Arg Pro Ser Glu Asn Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  182
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  182

Trp Ile Phe Pro Gly Thr Gly Glu Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Val 
    


<210>  183
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  183

Ser Trp Asn Tyr Asp Ala Arg Trp Gly Tyr 
1               5                   10  


<210>  184
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  184

Arg Ala Ser Glu Ser Ile Asp Ser Phe Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  185
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  185

Gln Gln Ser Asn Glu Ala Pro Phe Thr 
1               5                   


<210>  186
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  186

Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  187
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  187

Arg Ala Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  188
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  188

Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  189
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  189

Arg Ala Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  190
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  190

Arg Ala Ser Asn Leu Val Ser 
1               5           


<210>  191
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  191

Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  192
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  192

Arg Ala Ser Glu Thr Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  193
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  193

Trp Ile Phe Pro Gly Asn Asn Glu Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  194
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  194

Arg Ala Ser Glu Ile Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  195
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  195

Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Ser Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  196
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  196

Arg Ala Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  197
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  197

Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  198
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  198

Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Asn Phe Arg 
1               5                   10                  15      


Ala 
    


<210>  199
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  199

Arg Pro Ser Glu Asn Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  200
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  200

Trp Ile Phe Pro Gly Ser Gly Asp Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  201
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  201

Arg Val Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  202
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  202

Trp Ile Phe Leu Gly Ser Gly Glu Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  203
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  203

Arg Ala Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Ile His 
1               5                   10                  15  


<210>  204
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  204

Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  205
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  205

Arg Ala Ser Glu Ser Ile Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  206
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  206

Trp Ile Phe Pro Gly Ser Gly Glu Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Val 
    


<210>  207
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  207

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  208
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  208

Ser Tyr Gly Val Ser 
1               5   


<210>  209
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  209

Ile Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Val Ser 
1               5                   10                  15      


<210>  210
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  210

Pro Asn Trp Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  211
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  211

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  212
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  212

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  213
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  213

Gln Gln Gly Ile Thr Leu Pro Leu Thr 
1               5                   


