                         SEQUENCE LISTING

<110>  Nanjing Legend Biotech Co., Ltd.
 
<120>  CD30-BINDING MOIETIES, CHIMERIC ANTIGEN RECEPTORS, AND USES 
       THEREOF

<130>  14553-001-888

<150>  PCT/CN2018/123977
<151>  2018-12-26

<160>  223   

<170>  PatentIn version 3.5

<210>  1
<211>  361
<212>  PRT
<213>  homo sapiens

<220>
<223>   human CD30 ECD

<400>  1

Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn Pro Ser 
1               5                   10                  15      


His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys Pro Met 
            20                  25                  30          


Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp Cys Arg 
        35                  40                  45              


Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg Cys Thr 
    50                  55                  60                  


Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro Cys 
65                  70                  75                  80  


Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met Phe Cys 
                85                  90                  95      


Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His Ser Val 
            100                 105                 110         


Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln Lys Asn 
        115                 120                 125             


Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys Ala Ser 
    130                 135                 140                 


Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln Ala Lys 
145                 150                 155                 160 


Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met Pro Val 
                165                 170                 175     


Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu Thr Arg 
            180                 185                 190         


Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp Pro Gly 
        195                 200                 205             


Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys Arg Lys 
    210                 215                 220                 


Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys Thr Ala 
225                 230                 235                 240 


Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro Cys Ala 
                245                 250                 255     


Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile Cys Ala 
            260                 265                 270         


Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro Ile Cys 
        275                 280                 285             


Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys Asp Thr 
    290                 295                 300                 


Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn Pro Thr 
305                 310                 315                 320 


Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln Ser Leu 
                325                 330                 335     


Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala 
            340                 345                 350         


Pro Val Ala Leu Ser Ser Thr Gly Lys 
        355                 360     


<210>  2
<211>  361
<212>  PRT
<213>  rhesus

<220>
<223>   rhesus CD30 ECD

<400>  2

Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys Arg Gly Asn Pro Gly 
1               5                   10                  15      


His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys Pro Thr 
            20                  25                  30          


Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Ala Asp Cys Arg 
        35                  40                  45              


Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys Thr 
    50                  55                  60                  


Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Met Pro Cys 
65                  70                  75                  80  


Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Gln Pro Gly Met Phe Cys 
                85                  90                  95      


Ala Val Ser Val Val Asn Ser Cys Ala Arg Cys Phe Phe His Ser Val 
            100                 105                 110         


Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln Lys Asn 
        115                 120                 125             


Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys Ala Ser 
    130                 135                 140                 


Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln Ala Lys 
145                 150                 155                 160 


Pro Thr Pro Val Ser Pro Ala Thr Ser Asn Ala Ser Thr Met Pro Leu 
                165                 170                 175     


Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu Thr Arg 
            180                 185                 190         


Ala Pro Gly Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp Pro Gly 
        195                 200                 205             


Leu Ser Pro Thr Gln Pro Cys Pro Gln Gly Ser Gly Asp Cys Arg Lys 
    210                 215                 220                 


Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys Thr Ala 
225                 230                 235                 240 


Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro Cys Ala 
                245                 250                 255     


Trp Asn Ser Ser Arg Ile Cys Glu Cys Arg Pro Gly Met Ile Cys Ala 
            260                 265                 270         


Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro Ile Cys 
        275                 280                 285             


Ala Ala Glu Thr Gly Thr Lys Pro Gln Asp Met Ala Glu Lys Asp Thr 
    290                 295                 300                 


Thr Phe Glu Ala Pro Pro Val Gly Thr Gln Pro Asp Cys Ser Pro Thr 
305                 310                 315                 320 


Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Leu Ser Ser 
                325                 330                 335     


Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala 
            340                 345                 350         


Pro Ile Ala Leu Ser Ser Thr Gly Lys 
        355                 360     


<210>  3
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRD1

<400>  3

Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn Pro Ser 
1               5                   10                  15      


His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys Pro Met 
            20                  25                  30          


Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp Cys Arg 
        35                  40                  45              


Lys Gln 
    50  


<210>  4
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRD2

<400>  4

Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg Cys 
1               5                   10                  15      


Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            20                  25                  30          


Cys Ala Trp Asn Ser Ser Arg Val Cys Glu 
        35                  40          


<210>  5
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRD3

<400>  5

Glu Cys Arg Pro Gly Met Phe Cys Ser Thr Ser Ala Val Asn Ser Cys 
1               5                   10                  15      


Ala Arg Cys Phe Phe His Ser Val Cys Pro Ala Gly Met Ile Val Lys 
            20                  25                  30          


Phe Pro Gly Thr Ala Gln Lys Asn Thr Val Cys Glu Pro Ala Ser 
        35                  40                  45          


<210>  6
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRD4

<400>  6

Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys Ala Ser Pro Glu Asn 
1               5                   10                  15      


Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln Ala Lys Pro Thr Pro 
            20                  25                  30          


Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met Pro Val Arg Gly Gly 
        35                  40                  45              


Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu Thr Arg Ala Pro Asp 
    50                  55                  60                  


Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp Pro Gly Leu Ser Pro 
65                  70                  75                  80  


Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys Arg Lys Gln 
                85                  90                  


<210>  7
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRD5

<400>  7

Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
1               5                   10                  15      


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            20                  25                  30          


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu 
        35                  40          


<210>  8
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRD6

<400>  8

Glu Cys Arg Pro Gly Met Ile Cys Ala Thr Ser Ala Thr Asn Ser Cys 
1               5                   10                  15      


Ala Arg Cys Val Pro Tyr Pro Ile Cys Ala Ala Glu Thr Val Thr Lys 
            20                  25                  30          


Pro Gln Asp Met Ala Glu Lys Asp Thr Thr Phe Glu Ala Pro Pro Leu 
        35                  40                  45              


Gly Thr Gln Pro Asp Cys Asn Pro Thr Pro Glu Asn Gly Glu Ala Pro 
    50                  55                  60                  


Ala Ser Thr Ser Pro Thr Gln Ser Leu Leu Val Asp Ser Gln Ala Ser 
65                  70                  75                  80  


Lys Thr Leu Pro Ile Pro Thr Ser Ala Pro Val Ala Leu Ser Ser Thr 
                85                  90                  95      


Gly Lys 
        


<210>  9
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863

<400>  9

Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu 
1               5                   10                  15      


Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Ala Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Val Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48433

<400>  10

Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu 
1               5                   10                  15      


Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Ala Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Val Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Leu Asn Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  11
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48463 

<400>  11

Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu 
1               5                   10                  15      


Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ala Asn Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Ala Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser His Gly Gly Thr Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg His Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Ala Asp Pro Arg Ser Asn Cys Arg Gly Gly Tyr Cys Cys Gly Tyr 
            100                 105                 110         


Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48481

<400>  12

Glu Val Gln Leu Val Ala Ser Gly Gly Gly Ser Val Gln Ala Gly Glu 
1               5                   10                  15      


Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ala Asp Ser 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Lys Gly Pro Gly Asn Val Cys Asp Leu Val 
        35                  40                  45              


Ala Ile Ile Arg Thr Asp Gly Thr Thr Tyr Tyr Gly Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Ala Asp Arg Glu Thr Ser Phe Ile Gly Gly Ser Trp Cys Val Ala Lys 
            100                 105                 110         


Tyr Trp Asp Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  13
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48508

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Arg Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn Ala Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Tyr Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Tyr Cys Cys Gly Asn Trp 
            100                 105                 110         


Gly Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542

<400>  14

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu 
1               5                   10                  15      


Thr Leu Arg Leu Ser Cys Thr Thr Ser Ala Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn Glu Cys Val Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Asn Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn Trp 
            100                 105                 110         


Gly Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53445

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Ile Phe Cys Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu Gly Ile Ala Thr Ile 
        35                  40                  45              


Tyr Thr Gly Gly Asp Ser Thr Tyr Tyr Asp Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Gly 
                85                  90                  95      


Gly Gln Glu Cys Tyr Leu Thr Asn Trp Val Ser Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574

<400>  16

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Arg Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Asp Cys 
                85                  90                  95      


Ala Ala Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  17
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53750

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Asp Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Arg Ala Pro Gly Asn Glu Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Tyr Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Asp Cys Cys Gly Asn Trp 
            100                 105                 110         


Gly Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS54233

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu 
1               5                   10                  15      


Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn Glu Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ala Ser Gln Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Tyr Leu Lys Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Pro Arg Arg Asn Cys Arg Gly Asn Cys Cys Gly Asn Trp Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863VH4

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  20
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863VH5

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  21
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863VH11

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  22
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863VH12

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  23
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48433VH4

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Leu Asn Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  24
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48433VH5

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Leu Asn Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  25
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48433VH11

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Leu Asn Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  26
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48433VH12

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Leu Asn Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  27
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48463VH4 

<400>  27

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser His Gly Gly Thr Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ala Asp Pro Arg Ser Asn Cys Arg Gly Gly Tyr Cys Cys Gly Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  28
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48463VH11 

<400>  28

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ser His Gly Gly Thr Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ala Asp Pro Arg Ser Asn Cys Arg Gly Gly Tyr Cys Cys Gly Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  29
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48481VH5

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Ser 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ala Ile Ile Arg Thr Asp Gly Thr Thr Tyr Tyr Gly Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Ala Asp Arg Glu Thr Ser Phe Ile Gly Gly Ser Trp Cys Val Ala Lys 
            100                 105                 110         


Tyr Trp Asp Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  30
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48481VH6

<400>  30

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Ser 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Val Cys Glu Leu Val 
        35                  40                  45              


Ala Ile Ile Arg Thr Asp Gly Thr Thr Tyr Tyr Gly Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Ala Asp Arg Glu Thr Ser Phe Ile Gly Gly Ser Trp Cys Val Ala Lys 
            100                 105                 110         


Tyr Trp Asp Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  31
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48481VH13

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Ser 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ala Ile Ile Arg Thr Asp Gly Thr Thr Tyr Tyr Gly Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Ala Asp Arg Glu Thr Ser Phe Ile Gly Gly Ser Trp Cys Val Ala Lys 
            100                 105                 110         


Tyr Trp Asp Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  32
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48481VH14

<400>  32

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Ser 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Val Cys Glu Leu Val 
        35                  40                  45              


Ala Ile Ile Arg Thr Asp Gly Thr Thr Tyr Tyr Gly Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Ala Asp Arg Glu Thr Ser Phe Ile Gly Gly Ser Trp Cys Val Ala Lys 
            100                 105                 110         


Tyr Trp Asp Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  33
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48508VH4

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Tyr Cys Cys Gly Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  34
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48508VH5

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Tyr Cys Cys Gly Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48508VH11

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Tyr Cys Cys Gly Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  36
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48508VH12

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Tyr Cys Cys Gly Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  37
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542VH5

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542VH12

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  39
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53445VH4

<400>  39

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Phe Cys Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Ile Ala Thr Ile 
        35                  40                  45              


Tyr Thr Gly Gly Asp Ser Thr Tyr Tyr Asp Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly 
                85                  90                  95      


Gly Gln Glu Cys Tyr Leu Thr Asn Trp Val Ser Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  40
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53445VH11

<400>  40

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Phe Cys Met Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Ile Ala Thr Ile 
        35                  40                  45              


Tyr Thr Gly Gly Asp Ser Thr Tyr Tyr Asp Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly 
                85                  90                  95      


Gly Gln Glu Cys Tyr Leu Thr Asn Trp Val Ser Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  41
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574VH4

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  42
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574VH5

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  43
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574VH6

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  44
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574VH11

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Arg Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  45
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574VH12

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Arg Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  46
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574VH13

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Arg Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  47
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53750VH4

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Asp Cys Cys Gly Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  48
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53750VH5

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Asp Cys Cys Gly Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  49
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53750VH11

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Asp Cys Cys Gly Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  50
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53750VH12

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asp Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Asp Cys Cys Gly Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  51
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS54233VH4

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ala Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Pro Arg Arg Asn Cys Arg Gly Asn Cys Cys Gly Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  52
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS54233VH5

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ala Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Pro Arg Arg Asn Cys Arg Gly Asn Cys Cys Gly Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  53
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS54233VH11

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ala Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Pro Arg Arg Asn Cys Arg Gly Asn Cys Cys Gly Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  54
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS54233VH12

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Pro 
            20                  25                  30          


Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val 
        35                  40                  45              


Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ala Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Pro Arg Arg Asn Cys Arg Gly Asn Cys Cys Gly Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  55
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F11 scFv linker

<400>  55

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3 linker

<400>  56

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S linker

<400>  57

Gly Gly Gly Gly Ser 
1               5   


<210>  58
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57911 scFv

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ala Leu Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    130                 135                 140                 


Ala Ser Gly Phe Asn Ile Ser Ser Ser Tyr Ile His Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Tyr Tyr 
                165                 170                 175     


Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Pro Tyr Gly 
    210                 215                 220                 


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235             


<210>  59
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   AS57659 scFv

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Tyr Leu Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    130                 135                 140                 


Ala Ser Gly Phe Asn Ile Tyr Ser Tyr Tyr Ile His Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser Ser Tyr 
                165                 170                 175     


Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Trp Phe Ser Tyr 
    210                 215                 220                 


Pro Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


<210>  60
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57765 scFv

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Tyr Ser Leu Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Ser Tyr Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Tyr Pro Tyr 
                165                 170                 175     


Ser Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Ala Val His 
    210                 215                 220                 


Trp His Gly Tyr Gly Gly Gly Tyr Tyr Tyr Gly Leu Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  61
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  61

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  62
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-alpha hinge 

<400>  62

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  63
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-alpha TM

<400>  63

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  64
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cytoplasmic portion of the 4-1BB (CD137) 

<400>  64

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  65
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cytoplasmic portion of the CD3-zeta

<400>  65

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  66
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  66

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  67
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length CCR4

<400>  67

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  68
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dnTGF-beta-RII

<400>  68

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser 
        195                 


<210>  69
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1CD28

<400>  69

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Cys Pro Ser Pro Leu 
145                 150                 155                 160 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
                165                 170                 175     


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            180                 185                 190         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        195                 200                 205             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    210                 215                 220                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 235 


<210>  70
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863bbz

<400>  70

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser 
        35                  40                  45              


Thr Phe Gly Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Ala Cys Glu Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Val 
                85                  90                  95      


Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg 
        115                 120                 125             


Cys Cys Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365     


<210>  71
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48433bbz

<400>  71

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Ser 
        35                  40                  45              


Thr Phe Gly Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Ala Cys Glu Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Val 
                85                  90                  95      


Ser Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg 
        115                 120                 125             


Cys Cys Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365     


<210>  72
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48463bbz

<400>  72

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val His Leu Met Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ala Asn Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Ala Cys Glu Leu Val Ser Ile Ile Ser Ser His Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Ala 
                85                  90                  95      


Glu Asn Thr Val Tyr Leu Arg Met Thr Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Leu Tyr Tyr Cys Val Ala Asp Pro Arg Ser Asn Cys Arg Gly Gly 
        115                 120                 125             


Tyr Cys Cys Gly Tyr Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
145                 150                 155                 160 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                165                 170                 175     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            180                 185                 190         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        195                 200                 205             


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                245                 250                 255     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            260                 265                 270         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        275                 280                 285             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    290                 295                 300                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
305                 310                 315                 320 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                325                 330                 335     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            340                 345                 350         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365         


<210>  73
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48481bbz

<400>  73

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Ala Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ala Asp Ser Ala Met Gly Trp Tyr Arg Lys Gly Pro Gly Asn 
    50                  55                  60                  


Val Cys Asp Leu Val Ala Ile Ile Arg Thr Asp Gly Thr Thr Tyr Tyr 
65                  70                  75                  80  


Gly Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Asp Arg Glu Thr Ser Phe Ile Gly Gly Ser 
        115                 120                 125             


Trp Cys Val Ala Lys Tyr Trp Asp Gln Gly Thr Gln Val Thr Val Ser 
    130                 135                 140                 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    210                 215                 220                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
225                 230                 235                 240 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


<210>  74
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48508bbz

<400>  74

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Arg Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Ala Cys Glu Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Phe Leu Tyr Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Gly Asn Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365     


<210>  75
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542bbz

<400>  75

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Met Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Glu Cys Val Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Phe Leu Asn Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365     


<210>  76
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53750bbz

<400>  76

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Thr Asp Asp Gly Pro Asp Met Ala Trp Tyr Arg Arg Ala Pro Gly Asn 
    50                  55                  60                  


Glu Cys Glu Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Phe Leu Tyr Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Pro Asp Pro Arg Arg Asn Cys Arg Gly Gly Asp 
        115                 120                 125             


Cys Cys Gly Asn Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365     


<210>  77
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS54233bbz

<400>  77

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Glu Cys Glu Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Thr Asp Ser Val Lys Gly Arg Phe Thr Ala Ser Gln Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Ser Leu Tyr Leu Lys Ser Leu Gln Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Asp Pro Arg Arg Asn Cys Arg Gly Asn Cys 
        115                 120                 125             


Cys Gly Asn Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser Thr Thr 
    130                 135                 140                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
145                 150                 155                 160 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                165                 170                 175     


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
            180                 185                 190         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        195                 200                 205             


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
    210                 215                 220                 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
225                 230                 235                 240 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
                245                 250                 255     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
            260                 265                 270         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        275                 280                 285             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    290                 295                 300                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
305                 310                 315                 320 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                325                 330                 335     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            340                 345                 350         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365 


<210>  78
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53445bbz

<400>  78

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr 
        35                  40                  45              


Ile Phe Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Ala Arg Glu 
    50                  55                  60                  


Gly Ile Ala Thr Ile Tyr Thr Gly Gly Asp Ser Thr Tyr Tyr Asp Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Gly Gly Gln Glu Cys Tyr Leu Thr Asn Trp Val Ser 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr Pro 
    130                 135                 140                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
145                 150                 155                 160 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                165                 170                 175     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
            180                 185                 190         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        195                 200                 205             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    210                 215                 220                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
225                 230                 235                 240 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                245                 250                 255     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            260                 265                 270         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        275                 280                 285             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    290                 295                 300                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                325                 330                 335     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            340                 345                 350         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360             


<210>  79
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574bbz

<400>  79

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Ile Tyr Ser Ser Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Trp Val Ala Arg Ile His Thr Gly Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Asp Cys Ala Ala Gly Arg Val Val Leu Gly Ala Val Val 
        115                 120                 125             


Cys Thr Asn Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
145                 150                 155                 160 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                165                 170                 175     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            180                 185                 190         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        195                 200                 205             


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                245                 250                 255     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            260                 265                 270         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        275                 280                 285             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    290                 295                 300                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
305                 310                 315                 320 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                325                 330                 335     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            340                 345                 350         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365         


<210>  80
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57911bbz

<400>  80

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
            100                 105                 110         


His Ala Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Ser Ser Tyr Ile 
                165                 170                 175     


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr 
            180                 185                 190         


Ile Ser Ser Tyr Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gly Tyr Pro Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  81
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57659bbz

<400>  81

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro 
            100                 105                 110         


Tyr Tyr Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Ser Tyr Tyr Ile 
                165                 170                 175     


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser 
            180                 185                 190         


Ile Tyr Ser Ser Tyr Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Ser Trp Phe Ser Tyr Pro Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                325                 330                 335     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            340                 345                 350         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        355                 360                 365             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg 
                


<210>  82
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57765bbz

<400>  82

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala 
            100                 105                 110         


Tyr Tyr Ser Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Ser Tyr 
                165                 170                 175     


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            180                 185                 190         


Tyr Ile Tyr Pro Tyr Ser Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Pro Ala Val His Trp His Gly Tyr Gly Gly Gly Tyr Tyr Tyr Gly 
                245                 250                 255     


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  83
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542dis-bbz

<400>  83

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Met Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Glu Cys Val Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Phe Leu Asn Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Met Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
145                 150                 155                 160 


Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Thr Ser Ala Phe Thr 
                165                 170                 175     


Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn Glu 
            180                 185                 190         


Cys Val Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Val Phe Leu Asn Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys 
                245                 250                 255     


Cys Ala Asn Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  84
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542dil-bbz

<400>  84

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Met Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Glu Cys Val Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Phe Leu Asn Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Met 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu Thr Leu 
                165                 170                 175     


Arg Leu Ser Cys Thr Thr Ser Ala Phe Thr Phe Asp Gly Pro Asp Met 
            180                 185                 190         


Ala Trp Tyr Arg Gln Ala Pro Gly Asn Glu Cys Val Leu Val Ser Ile 
        195                 200                 205             


Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu Asn Leu 
225                 230                 235                 240 


Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Asp 
                245                 250                 255     


Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn Trp Gly Pro 
            260                 265                 270         


Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
            340                 345                 350         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        355                 360                 365             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    370                 375                 380                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg 
            500             


<210>  85
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542-AS53574bil-bbz

<400>  85

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Met Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Glu Cys Val Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Phe Leu Asn Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
145                 150                 155                 160 


Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn Cys Met 
            180                 185                 190         


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Arg 
        195                 200                 205             


Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Asp Cys Ala Ala 
                245                 250                 255     


Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210>  86
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574-AS48542bil-bbz

<400>  86

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Ile Tyr Ser Ser Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Trp Val Ala Arg Ile His Thr Gly Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Asp Cys Ala Ala Gly Arg Val Val Leu Gly Ala Val Val 
        115                 120                 125             


Cys Thr Asn Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Met Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu Thr 
                165                 170                 175     


Leu Arg Leu Ser Cys Thr Thr Ser Ala Phe Thr Phe Asp Gly Pro Asp 
            180                 185                 190         


Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn Glu Cys Val Leu Val Ser 
        195                 200                 205             


Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu Asn 
225                 230                 235                 240 


Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu 
                245                 250                 255     


Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn Trp Gly 
            260                 265                 270         


Pro Gly Thr Gln Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863-CDR1

<400>  87

Gly Ser Thr Phe Gly Asp Ser Asp Met Gly 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48463-CDR1

<400>  88

Gly Phe Thr Phe Ala Asn Ser Asp Met Gly 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48481-CDR1

<400>  89

Gly Phe Thr Phe Ala Asp Ser Ala Met Gly 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48508-CDR1

<400>  90

Arg Phe Thr Phe Asp Gly Pro Asp Met Ala 
1               5                   10  


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542-CDR1

<400>  91

Ala Phe Thr Phe Asp Gly Pro Asp Met Ala 
1               5                   10  


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53445-CDR1

<400>  92

Gly Tyr Ile Phe Cys Met Gly 
1               5           


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574-CDR1

<400>  93

Gly Tyr Ile Tyr Ser Ser Asn Cys Met Gly 
1               5                   10  


<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53750-CDR1

<400>  94

Gly Phe Thr Asp Asp Gly Pro Asp Met Ala 
1               5                   10  


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS54233-CDR1

<400>  95

Gly Phe Thr Phe Asp Gly Pro Asp Met Ala 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57659VH-CDR1

<400>  96

Gly Phe Asn Ile Tyr Ser Tyr Tyr Ile His 
1               5                   10  


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57765VH-CDR1

<400>  97

Gly Phe Asn Ile Tyr Tyr Ser Tyr Met His 
1               5                   10  


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57911VH-CDR1

<400>  98

Gly Phe Asn Ile Ser Ser Ser Tyr Ile His 
1               5                   10  


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57659VL-CDR1

<400>  99

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  100
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863-CDR2

<400>  100

Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48463-CDR2

<400>  101

Ile Ile Ser Ser His Gly Gly Thr Thr Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  102
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48481-CDR2

<400>  102

Ile Ile Arg Thr Asp Gly Thr Thr Tyr Tyr Gly Asp Ser Ala Lys Gly 
1               5                   10                  15      


<210>  103
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48508-CDR2

<400>  103

Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  104
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542-CDR2

<400>  104

Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53445-CDR2

<400>  105

Thr Ile Tyr Thr Gly Gly Asp Ser Thr Tyr Tyr Asp Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  106
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574-CDR2

<400>  106

Arg Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57659VH-CDR2

<400>  107

Ser Ile Tyr Ser Ser Tyr Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57765VH-CDR2

<400>  108

Tyr Ile Tyr Pro Tyr Ser Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57911VH-CDR2

<400>  109

Tyr Ile Ser Ser Tyr Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  110
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57765VL-CDR2

<400>  110

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  111
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863-CDR3

<400>  111

Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr 
1               5                   10                  


<210>  112
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48433-CDR3

<400>  112

Asp Leu Arg Leu Asn Cys Arg Asp Gly Arg Cys Cys Gly Tyr 
1               5                   10                  


<210>  113
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48463-CDR3

<400>  113

Asp Pro Arg Ser Asn Cys Arg Gly Gly Tyr Cys Cys Gly Tyr 
1               5                   10                  


<210>  114
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48481-CDR3

<400>  114

Asp Arg Glu Thr Ser Phe Ile Gly Gly Ser Trp Cys Val Ala Lys Tyr 
1               5                   10                  15      


<210>  115
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48508-CDR3

<400>  115

Asp Pro Arg Arg Asn Cys Arg Gly Gly Tyr Cys Cys Gly Asn 
1               5                   10                  


<210>  116
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542-CDR3

<400>  116

Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn 
1               5                   10                  


<210>  117
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53445-CDR3

<400>  117

Gly Gly Gln Glu Cys Tyr Leu Thr Asn Trp Val Ser Tyr 
1               5                   10              


<210>  118
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574-CDR3

<400>  118

Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr 
1               5                   10                  


<210>  119
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53750-CDR3

<400>  119

Asp Pro Arg Arg Asn Cys Arg Gly Gly Asp Cys Cys Gly Asn 
1               5                   10                  


<210>  120
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS54233-CDR3

<400>  120

Asp Pro Arg Arg Asn Cys Arg Gly Asn Cys Cys Gly Asn 
1               5                   10              


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57659VH-CDR3

<400>  121

Ser Trp Phe Ser Tyr Pro Gly Leu Asp Tyr 
1               5                   10  


<210>  122
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57765VH-CDR3

<400>  122

Pro Ala Val His Trp His Gly Tyr Gly Gly Gly Tyr Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Tyr 
        


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57911VH-CDR3

<400>  123

Gly Tyr Pro Tyr Gly Met Asp Tyr 
1               5               


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57659VL-CDR3

<400>  124

Gln Gln Pro Tyr Tyr Leu Ile Thr 
1               5               


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57765VL-CDR3

<400>  125

Gln Gln Ala Tyr Tyr Ser Leu Ile Thr 
1               5                   


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57911VL-CDR3

<400>  126

Gln Gln Ser His Ala Leu Ile Thr 
1               5               


<210>  127
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge

<400>  127

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  128
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 TM

<400>  128

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  129
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cytoplasmic portion of CD28

<400>  129

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  130
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS47863 sdAb

<400>  130
caggtgcaat tggaggagtc tgggggaggc tcggtgcagg ctggagagac tctgagactc       60

tcctgtacag cctctggatc cacttttggt gattctgaca tgggctggta ccgccaggct      120

ccaggaaatg cgtgcgagtt ggtatcaatt attagtagtg acggtaggac atactatgtg      180

gactccgtga agggccgatt caccatctcc caagacaacg ccgtgagcac ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacaca ggcgtgtatt actgtgcggc agacctccgc      300

caatattgta gggatggtcg ctgctgcggt tattggggcc aggggaccca ggtcaccgtc      360

tcctca                                                                 366


<210>  131
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48433 sdAb

<400>  131
cagattcagc tggtggagtc tgggggaggc tcggtgcagg ctggagagac tctgagactc       60

tcctgtacag cctctggatc cacttttggt gattctgaca tgggctggta ccgccaggct      120

ccagggaatg cgtgcgagtt ggtgtcaatt attagtagtg acgggcggac atactatgtg      180

gactccgtga agggccgatt caccatctcc caagacaacg ccgtgagcac ggtgtatctg      240

caaatgaaca gcctgaatcc tgaggacaca ggcgtgtatt actgtgcggc agacctccgc      300

ctcaattgta gggatggtcg ctgctgcggt tattggggcc aggggaccca ggtcaccgtc      360

tcctca                                                                 366


<210>  132
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48463 sdAb

<400>  132
caggtgcacc tgatggagtc tgggggaggc tcggtgcagg ctggagagac tctgagactc       60

tcctgtacag cctctggatt cacttttgct aattctgaca tgggctggta ccgccaggct      120

ccaggaaatg cgtgcgagtt ggtctcaatt attagtagtc atggtggtac gacatactat      180

gtagactccg tgaagggccg attcaccatc tcccggcaca acgccgagaa cacggtgtat      240

ctgcgaatga ctagcctgaa acctgaggac acagccctat attactgtgt cgcagacccg      300

aggtcaaatt gtcgtggtgg ttactgctgt ggttactggg gcccggggac ccaggtcacc      360

gtctcctca                                                              369


<210>  133
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48481 sdAb

<400>  133
gaggtgcaac tggtggcgtc tgggggaggc tcggtgcagg ctggagagac tctgagactc       60

tcctgtacag cctctggatt cacttttgct gattctgcca tgggctggta ccgaaagggt      120

ccagggaatg tgtgcgactt ggtagcaatt attaggacag atggtaccac atactatggc      180

gactccgcga agggccgatt caccatctcc cgagacaacg ccaagagcac gctgtatctg      240

caaatgaaca gcctgaaacc tgaggataca gccgtgtatt tctgtgcggc agaccgggag      300

acgtctttta tcggtggtag ctggtgtgtt gctaagtact gggaccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  134
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48508 sdAb

<400>  134
gaggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcatgtacag cctctagatt cacttttgat ggtcccgaca tggcctggta ccgccaggct      120

ccagggaatg cgtgcgagtt ggtctcaatt attagtgctg atggtagaac ctactataca      180

gactccgtga agggccgatt caccatctcc cgagacaacg ccaagaacac ggtgttcctg      240

tatttgaaca gcctgcaacc tgaggacaca gccgtatatt actgtgcgcc agatccccgt      300

agaaattgta gaggtggtta ttgctgtggc aactggggcc cggggaccca ggtcaccgtc      360

tcctca                                                                 366


<210>  135
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48542 sdAb

<400>  135
cagatgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagagac tctgagactc       60

tcatgtacaa cctctgcctt cacttttgat ggtcccgaca tggcctggta ccgccaggct      120

ccagggaatg agtgcgtgtt ggtctcaatt attagtgctg atggtagaac ctactatgca      180

gactccgtga agggccgatt caccatctcc cgagacaacg ccaagaacac ggtgttcctg      240

aatttgaaca gcctgcaacc tgaggacaca gccgtatatt actgtgcgtt agatccccgt      300

aaaaattgta gaggtggtta ttgctgtgcc aactggggcc cggggaccca ggtcaccgtc      360

tcctca                                                                 366


<210>  136
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53445 sdAb

<400>  136
caggtgcagc tggtggagtc tgggggaggc tcggtacagg ctggagggtc tctgagactc       60

tcctgtacag cctctggata cattttttgc atgggctggt tccgccaggc tccagggaag      120

gcccgcgagg ggatcgcaac tatttatacg ggtggtgata gcacatatta tgacgactcc      180

gtgaagggcc gattcaccat ctcccgggac aacgccaaga acacggtgta tctgcaaatg      240

aacagcctga aacctgagga cactgccatg tactactgtg cggcaggggg ccaagagtgc      300

tatttaacga actgggttag ctactggggc caggggaccc aggtcaccgt ctcctca         357


<210>  137
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53574 sdAb

<400>  137
caggtgaagt tagtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggata catctacagt agtaactgca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgagtg ggtcgcacgt attcatactg gtagtggtag cacatactat      180

gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtac      240

ctgcaaatga acagcctgag acctgaggac actgccatgt acgactgtgc ggcaggccga      300

gtggtacttg gtgcggtggt ctgcacgaat gagtactggg gccaggggac ccaggtcacc      360

gtctcctca                                                              369


<210>  138
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53750 sdAb

<400>  138
gaggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcatgtacag cctctggatt cactgatgat ggtcccgaca tggcctggta ccgccgggct      120

ccagggaatg agtgcgagtt ggtctcaatt attagtgctg atggtagaac ctactataca      180

gactccgtga aggggcgatt caccatctcc cgagacaacg ccaaaaacac ggtgttcctg      240

tatttgaaca gcctgcaacc tgaggacaca gccgtatatt actgtgcgcc agatccccgt      300

agaaattgta gaggtggtga ttgctgtggc aactggggcc cggggaccca ggtcaccgtc      360

tcctca                                                                 366


<210>  139
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS54233 sdAb

<400>  139
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagagac tctgagactc       60

tcatgtacag cctctggatt cacttttgat ggtcccgaca tggcctggta ccgccaggct      120

ccagggaatg agtgcgagtt ggtctcaatt attagtgctg atggtagaac ctactataca      180

gactccgtga agggccgatt caccgcctcc caagacaacg ccaagaacac ggtgtctcta      240

tatttgaaaa gcctgcaacc tgaggacaca gccgtatatt actgtgcggc agatccccgt      300

agaaattgta gaggtaattg ctgtggcaac tggggcccgg ggacccaggt caccgtctcc      360

tca                                                                    363


<210>  140
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS47863VH4 sdAb

<400>  140
gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg       60

tcctgcgcag catccggatc taccttcggc gactccgata tgggctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtccatc atcagctccg acggcaggac atactatgtg      180

gattctgtga agggccgctt taccatctct caggacaaca gcaagaatac actgtatctg      240

cagatgaact ctctgcgggc cgaggatacc gccgtgtact attgcgccgc cgacctgaga      300

cagtactgtc gggatggcag atgctgtggc tattggggcc agggcaccct ggtgacagtg      360

tctagc                                                                 366


<210>  141
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS47863VH5 sdAb

<400>  141
gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg       60

tcctgcgcag catccggatc taccttcggc gactccgata tgggctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtccatc atcagctccg acggcaggac atactatgtg      180

gattctgtga agggccgctt taccatctct caggacaaca gcaagaatac agtgtatctg      240

cagatgaact ctctgcgggc cgaggatacc gccgtgtact attgcgccgc cgacctgaga      300

cagtactgtc gggatggcag atgctgtggc tattggggcc agggcaccct ggtgacagtg      360

tctagc                                                                 366


<210>  142
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS47863VH11 sdAb

<400>  142
gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg       60

tcctgcgcag catccggatc taccttcggc gactccgata tgggctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtctatc atcagctccg acggcaggac atactatgtg      180

gattctgtga agggccgctt taccatcagc caggacaacg ccaagaatac actgtatctg      240

cagatgaact ccctgcggcc cgaggatacc gccgtgtact attgcgccgc cgacctgaga      300

cagtactgtc gggatggcag atgctgtggc tattggggcc agggcaccct ggtgacagtg      360

tctagc                                                                 366


<210>  143
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS47863VH12 sdAb

<400>  143
gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg       60

tcctgcgcag catccggatc taccttcggc gactccgata tgggctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtctatc atcagctccg acggcaggac atactatgtg      180

gattctgtga agggccgctt taccatcagc caggacaacg ccaagaatac agtgtatctg      240

cagatgaact ccctgcggcc cgaggatacc gccgtgtact attgcgccgc cgacctgaga      300

cagtactgtc gggatggcag atgctgtggc tattggggcc agggcaccct ggtgacagtg      360

tctagc                                                                 366


<210>  144
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48433VH4 sdAb

<400>  144
gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg       60

tcctgcgcag catccggatc taccttcggc gactccgata tgggctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtccatc atcagctccg acggcaggac atactatgtg      180

gattctgtga agggccgctt taccatctct caggacaaca gcaagaatac actgtacctg      240

cagatgaact ctctgcgggc cgaggatacc gccgtgtact attgcgccgc cgacctgaga      300

ctgaattgtc gggatggcag atgctgtggc tattggggcc agggcaccct ggtgacagtg      360

tctagc                                                                 366


<210>  145
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48433VH5 sdAb

<400>  145
gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg       60

tcctgcgcag catccggatc taccttcggc gactccgata tgggctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtccatc atcagctccg acggcaggac atactatgtg      180

gattctgtga agggccgctt taccatctct caggacaaca gcaagaatac agtgtacctg      240

cagatgaact ctctgcgggc cgaggatacc gccgtgtact attgcgccgc cgacctgaga      300

ctgaattgtc gggatggcag atgctgtggc tattggggcc agggcaccct ggtgacagtg      360

tctagc                                                                 366


<210>  146
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48433VH11 sdAb

<400>  146
gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg       60

tcctgcgcag catccggatc taccttcggc gactccgata tgggctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtctatc atcagctccg acggcaggac atactatgtg      180

gattctgtga agggccgctt taccatcagc caggacaacg ccaagaatac actgtacctg      240

cagatgaact ccctgcggcc cgaggatacc gccgtgtact attgcgccgc cgacctgaga      300

ctgaattgtc gggatggcag atgctgtggc tattggggcc agggcaccct ggtgacagtg      360

tctagc                                                                 366


<210>  147
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48433VH12 sdAb

<400>  147
gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggcag cctgaggctg       60

tcctgcgcag catccggatc taccttcggc gactccgata tgggctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtctatc atcagctccg acggcaggac atactatgtg      180

gattctgtga agggccgctt taccatcagc caggacaacg ccaagaatac agtgtacctg      240

cagatgaact ccctgcggcc cgaggatacc gccgtgtact attgcgccgc cgacctgaga      300

ctgaattgtc gggatggcag atgctgtggc tattggggcc agggcaccct ggtgacagtg      360

tctagc                                                                 366


<210>  148
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48463VH4 sdAb

<400>  148
gaggtgcagc tgctggagtc cggaggagga ctggtgcagc caggaggctc cctgaggctg       60

tcttgcgcag caagcggctt cacctttgcc aactctgaca tgggatggta caggcaggca      120

cctggcaagg gatgtgagct ggtgagcatc atcagctccc acggcggcac cacatactat      180

gtggactccg tgaagggcag gttcaccatc tcccgcgata actctaagaa tacactgtat      240

ctgcagatga actctctgcg ggccgaggac acagccgtgt actattgcgt ggccgatccc      300

cggagcaatt gtagaggcgg ctactgctgt ggctattggg gccagggcac cctggtgaca      360

gtgtctagc                                                              369


<210>  149
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48463VH11 sdAb

<400>  149
gaggtgcagc tgctggagtc cggaggagga ctggtgcagc caggaggctc cctgaggctg       60

tcttgcgcag caagcggctt cacctttgcc aacagcgaca tgggatggta caggcaggca      120

ccaggcaagg gatgtgagct ggtgtccatc atcagctccc acggcggcac cacatactat      180

gtggactccg tgaagggcag gttcaccatc tctcgcgata acgccaagaa tacactgtat      240

ctgcagatga actctctgcg gcccgaggac acagccgtgt actattgcgt ggccgatcct      300

cggagcaatt gtagaggcgg ctactgctgt ggctattggg gccagggcac cctggtgaca      360

gtgtctagc                                                              369


<210>  150
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48481VH5 sdAb

<400>  150
caggtgcagc tggtggagtc tggaggagga gtggtgcagc caggccggtc tctgagactg       60

agctgcgcag catccggctt cacctttgcc gacagcgcca tgggatggta caggcaggca      120

cctggcaagg gatgtgagct ggtggccatc atcagaacag acggcaccac atactatggc      180

gatagcgcca agggcaggtt caccatctct cgcgataaca gcaagaatac actgtacctg      240

cagatgaact ccctgagggc agaggacacc gccgtgtatt tctgcgccgc cgatagagag      300

acatccttta tcggcggctc ttggtgcgtg gccaagtatt gggaccaggg caccctggtg      360

acagtgagct cc                                                          372


<210>  151
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48481VH6 sdAb DNA seque

<400>  151
caggtgcagc tggtggagtc tggaggagga gtggtgcagc caggccggtc tctgagactg       60

agctgcgcag catccggctt cacctttgcc gacagcgcca tgggatggta caggcaggca      120

cctggcaagg tatgtgagct ggtggccatc atcagaacag acggcaccac atactatggc      180

gatagcgcca agggcaggtt caccatctct cgcgataaca gcaagaatac actgtacctg      240

cagatgaact ccctgagggc agaggacacc gccgtgtatt tctgcgccgc cgatagagag      300

acatccttta tcggcggctc ttggtgcgtg gccaagtatt gggaccaggg caccctggtg      360

acagtgagct cc                                                          372


<210>  152
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48481VH13 sdAb

<400>  152
caggtgcagc tggtggagag cggaggagga gtggtgcagc caggacggtc tctgagactg       60

agctgcgcag catccggctt cacctttgca gactccgcaa tgggatggta caggcaggca      120

cctggcaagg gatgtgagct ggtggccatc atcagaacag acggcaccac atactatggc      180

gattccgcca agggcaggtt caccatctct cgcgataacg ccaagaatac actgtacctg      240

cagatgaact ctctgcggcc cgaggacacc gccgtgtatt tctgcgccgc cgatagagag      300

acatctttta tcggcggcag ctggtgtgtg gccaagtatt gggaccaggg caccctggtg      360

acagtgagct cc                                                          372


<210>  153
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48481VH14 sdAb

<400>  153
caggtgcagc tggtggagag cggaggagga gtggtgcagc caggacggtc tctgagactg       60

agctgcgcag catccggctt cacctttgca gactccgcaa tgggatggta caggcaggca      120

cctggcaagg tctgtgagct ggtggccatc atcagaacag acggcaccac atactatggc      180

gattccgcca agggcaggtt caccatctct cgcgataacg ccaagaatac actgtacctg      240

cagatgaact ctctgcggcc cgaggacacc gccgtgtatt tctgcgccgc cgatagagag      300

acatctttta tcggcggcag ctggtgtgtg gccaagtatt gggaccaggg caccctggtg      360

acagtgagct cc                                                          372


<210>  154
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48508VH4 sdAb

<400>  154
gaggtgcagc tggtggagtc tggaggagga ctggtgcagc caggaggctc cctgcggctg       60

tcttgcgccg ccagcagatt cacctttgac ggcccagata tggcatggta caggcaggca      120

ccaggcaagg gatgtgagct ggtgtctatc atcagcgccg acggccgcac ctactataca      180

gatagcgtga agggcaggtt caccatctcc cgcgacaact ctaagaatac actgtacctg      240

cagatgaact ccctgagggc agaggacacc gcagtgtact attgcgcccc cgatcctcgg      300

agaaactgtc ggggcggcta ttgctgtggc aattggggcc agggcaccac agtgacagtg      360

agctcc                                                                 366


<210>  155
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48508VH5 sdAb 

<400>  155
gaggtgcagc tggtggagtc tggaggagga ctggtgcagc caggaggctc cctgcggctg       60

tcttgcgccg ccagcagatt cacctttgac ggcccagata tggcatggta caggcaggca      120

ccaggcaagg gatgtgagct ggtgtctatc atcagcgccg acggccgcac ctactataca      180

gatagcgtga agggcaggtt caccatctcc cgcgacaact ctaagaatac agtgtacctg      240

cagatgaact ccctgagggc agaggacacc gcagtgtact attgcgcccc cgatcctcgg      300

agaaactgtc ggggcggcta ttgctgtggc aattggggcc agggcaccac agtgacagtg      360

agctcc                                                                 366


<210>  156
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48508VH11 sdAb

<400>  156
gaggtgcagc tggtggagag cggaggagga ctggtgcagc ctggaggctc cctgaggctg       60

tcttgcgcag caagcagatt cacctttgac ggcccagata tggcatggta caggcaggca      120

ccaggcaagg gatgtgagct ggtgtctatc atcagcgccg acggccgcac ctactataca      180

gattccgtga agggcaggtt caccatctct cgcgacaacg ccaagaatac actgtacctg      240

cagatgaact ccctgaggcc agaggacacc gcagtgtact attgcgcccc cgatcctcgg      300

agaaactgtc ggggcggcta ttgctgtggc aattggggcc agggcaccac agtgacagtg      360

agctcc                                                                 366


<210>  157
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48508VH12 sdAb 

<400>  157
gaggtgcagc tggtggagag cggaggagga ctggtgcagc ctggaggctc cctgaggctg       60

tcttgcgcag caagcagatt cacctttgac ggcccagata tggcatggta caggcaggca      120

ccaggcaagg gatgtgagct ggtgtctatc atcagcgccg acggccgcac ctactataca      180

gattccgtga agggcaggtt caccatctct cgcgacaacg ccaagaatac agtgtacctg      240

cagatgaact ccctgaggcc agaggacacc gcagtgtact attgcgcccc cgatcctcgg      300

agaaactgtc ggggcggcta ttgctgtggc aattggggcc agggcaccac agtgacagtg      360

agctcc                                                                 366


<210>  158
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48542VH5 sdAb 

<400>  158
gaggtgcagc tggtggagtc cggaggagga ctggtgcagc caggaggctc cctgaggctg       60

tcttgcgcca caagcgcctt cacctttgac ggccccgata tggcatggta caggcaggca      120

cctggcaagg gatgtgagct ggtgtctatc atcagcgccg acggccgcac atactatgcc      180

gattctgtga agggcaggtt cacaatctcc cgcgacaact ctaagaatac cgtgtacctg      240

cagatgaaca gcctgagggc agaggacacc gccgtgtact attgcgccct ggatccccgg      300

aagaactgta gaggcggcta ttgctgtgcc aattggggcc agggcacact ggtgaccgtg      360

agctcc                                                                 366


<210>  159
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS48542VH12 sdAb

<400>  159
gaggtgcagc tggtggagtc tggaggagga ctggtgcagc ctggaggctc cctgaggctg       60

tcttgcgcca caagcgcctt cacctttgac ggccccgata tggcatggta caggcaggca      120

cctggcaagg gatgtgagct ggtgtctatc atcagcgccg acggccgcac atactatgcc      180

gatagcgtga agggcaggtt cacaatctcc cgcgacaacg ccaagaatac cgtgtacctg      240

cagatgaaca gcctgcggcc agaggacacc gccgtgtact attgcgccct ggatccccgg      300

aagaactgta gaggcggcta ttgctgtgcc aattggggcc agggcacact ggtgaccgtg      360

agctcc                                                                 366


<210>  160
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53445VH4 sdAb

<400>  160
caggtgcagc tggtggagtc tggaggagga gtggtgcagc caggaggctc tctgaggctg       60

agctgcgcag catccggata catcttctgt atgggatggt ttaggcaggc acctggcaag      120

ggactggagg gaatcgccac catctataca ggcggcgact ccacctacta tgacgattct      180

gtgaagggcc ggttcaccat ctctagagat aacagcaaga atacactgta cctgcagatg      240

aacagcctga gggcagagga caccgcagtg tactattgcg cagcaggagg acaggagtgt      300

tacctgacaa attgggtgtc ctattggggc cagggcaccc tggtgacagt gagctcc         357


<210>  161
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53445VH11 sdAb 

<400>  161
caggtgcagc tggtggagag cggaggagga gtggtgcagc caggaggctc tctgcggctg       60

agctgcgccg cctccggcta catcttctgt atgggctggt ttaggcaggc acctggcaag      120

ggaagggagg gaatcgcaac catctataca ggcggcgact ctacctacta tgacgatagc      180

gtgaagggcc ggttcaccat ctccagagat aacgccaaga atacactgta cctgcagatg      240

aactctctga ggcccgagga caccgcagtg tactattgcg cagcaggagg acaggagtgt      300

tacctgacaa attgggtgtc ctattggggc cagggcaccc tggtgacagt gagctcc         357


<210>  162
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53574VH4 sdAb

<400>  162
gaggtgcagc tggtggagtc cggaggagga ctggtgcagc caggaggcag cctgcggctg       60

tcctgcgccg cctctggcta catctatagc tccaactgta tgggatggtt caggcaggca      120

cctggcaagg gactggagtg ggtgtctcgc atccacaccg gctccggctc tacatactat      180

gccgacagcg tgaagggccg gtttaccatc agcagagata actccaagaa tacactgtac      240

ctgcagatga actctctgcg ggccgaggac accgcagtgt actattgcgc agcaggaagg      300

gtggtgctgg gagcagtggt gtgtacaaat gagtattggg gccagggcac cctggtgaca      360

gtgtctagc                                                              369


<210>  163
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53574VH5 sdAb

<400>  163
gaggtgcagc tggtggagtc cggaggagga ctggtgcagc caggaggcag cctgcggctg       60

tcctgcgccg cctctggcta catctatagc tccaactgta tgggatggtt caggcaggca      120

cctggcaagg gactggagtg ggtgtctaga atccacaccg gctccggctc tacatactat      180

gccgacagcg tgaagggcag gtttaccatc agccaggata actccaagaa tacactgtac      240

ctgcagatga actctctgag ggccgaggac accgcagtgt actattgcgc agcaggaagg      300

gtggtgctgg gagcagtggt gtgtacaaat gagtattggg gccagggcac cctggtgaca      360

gtgtctagc                                                              369


<210>  164
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53574VH6 sdAb

<400>  164
gaggtgcagc tggtggagtc cggaggagga ctggtgcagc caggaggcag cctgcggctg       60

tcctgcgccg cctctggcta catctatagc tccaactgta tgggatggtt caggcaggca      120

cctggcaagg gcctggagtg ggtggccaga atccacaccg gctccggctc tacatactat      180

gccgactctg tgaagggcag gtttaccatc agccaggata actccaagaa tacactgtac      240

ctgcagatga acagcctgag ggccgaggac accgcagtgt actattgcgc agcaggaagg      300

gtggtgctgg gagcagtggt gtgtacaaat gagtattggg gccagggcac cctggtgaca      360

gtgtctagc                                                              369


<210>  165
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53574VH11 sdAb

<400>  165
gaggtgcagc tggtggagtc cggaggagga ctggtgcagc caggaggcag cctgaggctg       60

tcctgcgccg cctctggcta catctatagc tccaactgta tgggctggtt cagacaggca      120

cctggcaagg gaagggagtg ggtgtctaga atccacaccg gctccggctc tacatactat      180

gccgacagcg tgaagggcag gtttaccatc tcccgcgata acgccaagaa tacactgtac      240

ctgcagatga acagcctgag gccagaggac accgcagtgt actattgcgc agcaggaaga      300

gtggtgctgg gagcagtggt gtgtacaaat gagtattggg gccagggcac cctggtgaca      360

gtgtctagc                                                              369


<210>  166
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53574VH12 sdAb

<400>  166
gaggtgcagc tggtggagtc cggaggagga ctggtgcagc caggaggcag cctgcggctg       60

tcctgcgccg cctctggcta catctatagc tccaactgta tgggctggtt caggcaggca      120

cctggcaagg gaagggagtg ggtgtctaga atccacaccg gctccggctc tacatactat      180

gccgacagcg tgaagggccg gtttaccatc tcccaggata acgccaagaa tacactgtac      240

ctgcagatga acagcctgag gcccgaggac accgcagtgt actattgcgc agcaggaagg      300

gtggtgctgg gagcagtggt gtgtacaaat gagtattggg gccagggcac cctggtgaca      360

gtgtctagc                                                              369


<210>  167
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53574VH13 sdAb 

<400>  167
gaggtgcagc tggtggagtc tggaggagga ctggtgcagc caggaggcag cctgcggctg       60

tcctgcgccg cctctggcta catctatagc tccaactgta tgggctggtt caggcaggca      120

cctggcaagg gaagggagtg ggtggccaga atccacaccg gctccggctc tacatactat      180

gccgacagcg tgaagggccg gtttaccatc tcccaggata acgccaagaa tacactgtac      240

ctgcagatga acagcctgag gcccgaggac accgcagtgt actattgcgc agcaggaagg      300

gtggtgctgg gagcagtggt gtgtacaaat gagtattggg gccagggcac cctggtgaca      360

gtgtctagc                                                              369


<210>  168
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53750VH4 sdAb 

<400>  168

Gly Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Ala Gly Gly Ala Gly Gly Ala Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Cys Ala Gly Cys Cys Ala Gly Gly Ala Gly Gly Cys 
        35                  40                  45              


Thr Cys Cys Cys Thr Gly Ala Gly Gly Cys Thr Gly Thr Cys Thr Thr 
    50                  55                  60                  


Gly Cys Gly Cys Ala Gly Cys Ala Ala Gly Cys Gly Gly Cys Thr Thr 
65                  70                  75                  80  


Cys Ala Cys Cys Gly Ala Cys Gly Ala Thr Gly Gly Ala Cys Cys Ala 
                85                  90                  95      


Gly Ala Thr Ala Thr Gly Gly Cys Ala Thr Gly Gly Thr Ala Cys Ala 
            100                 105                 110         


Gly Gly Cys Ala Gly Gly Cys Ala Cys Cys Ala Gly Gly Cys Ala Ala 
        115                 120                 125             


Gly Gly Gly Ala Thr Gly Thr Gly Ala Gly Cys Thr Gly Gly Thr Gly 
    130                 135                 140                 


Thr Cys Thr Ala Thr Cys Ala Thr Cys Ala Gly Cys Gly Cys Cys Gly 
145                 150                 155                 160 


Ala Cys Gly Gly Cys Ala Gly Ala Ala Cys Cys Thr Ala Cys Thr Ala 
                165                 170                 175     


Thr Ala Cys Ala Gly Ala Thr Ala Gly Cys Gly Thr Gly Ala Ala Gly 
            180                 185                 190         


Gly Gly Cys Ala Gly Gly Thr Thr Thr Ala Cys Cys Ala Thr Cys Thr 
        195                 200                 205             


Cys Cys Cys Gly Cys Gly Ala Cys Ala Ala Cys Thr Cys Thr Ala Ala 
    210                 215                 220                 


Gly Ala Ala Thr Ala Cys Ala Cys Thr Gly Thr Ala Thr Cys Thr Gly 
225                 230                 235                 240 


Cys Ala Gly Ala Thr Gly Ala Ala Cys Thr Cys Cys Cys Thr Gly Ala 
                245                 250                 255     


Gly Gly Gly Cys Cys Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Cys 
            260                 265                 270         


Cys Gly Thr Gly Thr Ala Cys Thr Ala Thr Thr Gly Cys Gly Cys Cys 
        275                 280                 285             


Cys Cys Cys Gly Ala Thr Cys Cys Thr Cys Gly Gly Ala Gly Ala Ala 
    290                 295                 300                 


Ala Cys Thr Gly Thr Ala Gly Gly Gly Gly Ala Gly Gly Cys Gly Ala 
305                 310                 315                 320 


Cys Thr Gly Cys Thr Gly Thr Gly Gly Ala Ala Ala Thr Thr Gly Gly 
                325                 330                 335     


Gly Gly Ala Cys Ala Gly Gly Gly Cys Ala Cys Cys Ala Cys Ala Gly 
            340                 345                 350         


Thr Gly Ala Cys Ala Gly Thr Gly Ala Gly Cys Thr Cys Cys 
        355                 360                 365     


<210>  169
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53750VH5 sdAb

<400>  169
gaggtgcagc tggtggagtc tggaggagga ctggtgcagc caggaggctc cctgaggctg       60

tcttgcgcag caagcggctt caccgacgat ggaccagata tggcatggta caggcaggca      120

ccaggcaagg gatgtgagct ggtgtctatc atcagcgccg acggcagaac ctactataca      180

gatagcgtga agggcaggtt taccatctcc cgcgacaact ctaagaatac agtgtatctg      240

cagatgaact ccctgagggc cgaggacacc gccgtgtact attgcgcccc cgatcctcgg      300

agaaactgta ggggaggcga ctgctgtgga aattggggac agggcaccac agtgacagtg      360

agctcc                                                                 366


<210>  170
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53750VH11 sdAb 

<400>  170
gaggtgcagc tggtggagag cggaggagga ctggtgcagc ctggaggctc cctgaggctg       60

tcttgcgcag caagcggctt caccgacgat ggaccagata tggcatggta caggcaggca      120

ccaggcaagg gatgtgagct ggtgtctatc atcagcgccg acggcagaac ctactataca      180

gattccgtga agggcaggtt taccatctct cgcgacaacg ccaagaatac actgtatctg      240

cagatgaact ccctgaggcc cgaggacacc gccgtgtact attgcgcccc cgatcctcgg      300

agaaactgta ggggaggcga ctgctgtgga aattggggac agggcaccac agtgacagtg      360

agctcc                                                                 366


<210>  171
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53750VH12 sdAb

<400>  171
gaggtgcagc tggtggagag cggaggagga ctggtgcagc ctggaggctc cctgaggctg       60

tcttgcgcag caagcggctt caccgacgat ggaccagata tggcatggta caggcaggca      120

ccaggcaagg gatgtgagct ggtgtctatc atcagcgccg acggcagaac ctactataca      180

gattccgtga agggcaggtt taccatctct cgcgacaacg ccaagaatac agtgtatctg      240

cagatgaact ccctgaggcc cgaggacacc gccgtgtact attgcgcccc cgatcctcgg      300

agaaactgta ggggaggcga ctgctgtgga aattggggac agggcaccac agtgacagtg      360

agctcc                                                                 366


<210>  172
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS54233VH4 sdAb 

<400>  172
gaggtgcagc tggtggagtc tggaggagga ctggtgcagc caggaggctc cctgaggctg       60

tcttgcgcag caagcggctt cacctttgac ggacccgata tggcctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtctatc atcagcgccg acggcaggac ctactataca      180

gatagcgtga agggacgctt caccgcatcc caggacaact ctaagaatac actgtatctg      240

cagatgaaca gcctgcgggc cgaggacaca gccgtgtact attgcgccgc cgatccccgg      300

agaaactgta gaggcaattg ctgtggaaac tggggacagg gaaccctggt gacagtgagc      360

tcc                                                                    363


<210>  173
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS54233VH5 sdAb

<400>  173
gaggtgcagc tggtggagtc tggaggagga ctggtgcagc caggaggctc cctgaggctg       60

tcttgcgcag caagcggctt cacctttgac ggacccgata tggcctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtctatc atcagcgccg acggcaggac ctactataca      180

gatagcgtga agggacgctt caccgcatcc caggacaact ctaagaatac agtgtatctg      240

cagatgaaca gcctgcgggc cgaggacaca gccgtgtact attgcgccgc cgatccccgg      300

agaaactgta gaggcaattg ctgtggaaac tggggacagg gaaccctggt gacagtgagc      360

tcc                                                                    363


<210>  174
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS54233VH11 sdAb

<400>  174
gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggctc cctgaggctg       60

tcttgcgcag caagcggctt cacctttgac ggacccgata tggcctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtctatc atcagcgccg acggcaggac ctactataca      180

gattccgtga agggccgctt caccgcctct caggacaacg ccaagaatac actgtatctg      240

cagatgaaca gcctgcggcc agaggacaca gccgtgtact attgcgccgc cgatccccgg      300

agaaactgta gaggcaattg ctgtggaaac tggggacagg gaaccctggt gacagtgagc      360

tcc                                                                    363


<210>  175
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS54233VH12 sdAb 

<400>  175
gaggtgcagc tggtggagag cggaggagga ctggtgcagc caggaggctc cctgaggctg       60

tcttgcgcag caagcggctt cacctttgac ggacccgata tggcctggta cagacaggcc      120

cctggcaagg gctgtgagct ggtgtctatc atcagcgccg acggcaggac ctactataca      180

gattccgtga agggccgctt caccgcctct caggacaacg ccaagaatac agtgtatctg      240

cagatgaaca gcctgcggcc agaggacaca gccgtgtact attgcgccgc cgatccccgg      300

agaaactgta gaggcaattg ctgtggaaac tggggacagg gaaccctggt gacagtgagc      360

tcc                                                                    363


<210>  176
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5F11 scFv linker

<400>  176
ggcagcacct ccggatctgg caagccagga agcggagagg gcagcacaaa gggc             54


<210>  177
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (G4S)3 linker

<400>  177
ggaggaggag gaagcggagg aggaggatcc ggcggcggcg gctct                       45


<210>  178
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G4S linker

<400>  178
ggaggaggag gaagc                                                        15


<210>  179
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS57911 scFv

<400>  179
gacatccaga tgacccagag cccgagcagc ctgagcgcga gcgttggtga ccgtgttacc       60

attacctgcc gtgcgagcca gagcgttagc agcgcggtgg cgtggtacca gcaaaagccg      120

ggtaaagcgc cgaagctgct gatctatagc gcgagcagcc tgtatagcgg cgttccgagc      180

cgtttcagcg gtagccgtag cggcaccgac tttaccctga ccattagcag cctgcagccg      240

gaagatttcg caacttatta ctgtcagcaa tctcatgctc tgatcacgtt cggacagggc      300

accaaagttg agattaaagg aggaggagga agcggaggag gaggatccgg cggcggcggc      360

tctgaggttc aactggtgga gagcggtggt ggtctggttc agccgggtgg tagcctgcgt      420

ctgagctgcg cagcttctgg cttcaacatc tcttcttctt atatccactg ggtgcgtcag      480

gcgccgggta aaggcctgga atgggttgca tatatttctt cttattatag ctatacttat      540

tatgccgata gcgtcaaggg ccgtttcacc atcagcgcgg ataccagcaa aaacaccgca      600

tacctgcaaa tgaacagcct gcgtgcggaa gataccgccg tctattattg tgctcgcggt      660

tacccgtacg gtatggacta ctggggtcaa ggcaccctgg ttaccgtgag cagc            714


<210>  180
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS57659 scFv

<400>  180
gacatccaga tgacccagag cccgagcagc ctgagcgcga gcgttggtga ccgtgttacc       60

attacctgcc gtgcgagcca gagcgttagc agcgcggtgg cgtggtacca gcaaaagccg      120

ggtaaagcgc cgaagctgct gatctatagc gcgagcagcc tgtatagcgg cgttccgagc      180

cgtttcagcg gtagccgtag cggcaccgac tttaccctga ccattagcag cctgcagccg      240

gaagatttcg caacttatta ctgtcagcaa ccgtactacc tgatcacgtt cggacagggc      300

accaaagttg agattaaagg aggaggagga agcggaggag gaggatccgg cggcggcggc      360

tctgaggttc aactggtgga gagcggtggt ggtctggttc agccgggtgg tagcctgcgt      420

ctgagctgcg cagcttctgg cttcaacatc tattcttatt atatccactg ggtgcgtcag      480

gcgccgggta aaggcctgga atgggttgca tctatttatt cttcttatag ctctacttat      540

tatgccgata gcgtcaaggg ccgtttcacc atcagcgcgg ataccagcaa aaacaccgca      600

tacctgcaaa tgaacagcct gcgtgcggaa gataccgccg tctattattg tgctcgctct      660

tggttctctt acccgggttt ggactactgg ggtcaaggca ccctggttac cgtgagcagc      720


<210>  181
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS57765 scFv

<400>  181
gacatccaga tgacccagag cccgagcagc ctgagcgcga gcgttggtga ccgtgttacc       60

attacctgcc gtgcgagcca gagcgttagc agcgcggtgg cgtggtacca gcaaaagccg      120

ggtaaagcgc cgaagctgct gatctatagc gcgagcagcc tgtatagcgg cgttccgagc      180

cgtttcagcg gtagccgtag cggcaccgac tttaccctga ccattagcag cctgcagccg      240

gaagatttcg caacttatta ctgtcagcaa gcttactact ctctgatcac gttcggacag      300

ggcaccaaag ttgagattaa aggaggagga ggaagcggag gaggaggatc cggcggcggc      360

ggctctgagg ttcaactggt ggagagcggt ggtggtctgg ttcagccggg tggtagcctg      420

cgtctgagct gcgcagcttc tggcttcaac atctattatt cttatatgca ctgggtgcgt      480

caggcgccgg gtaaaggcct ggaatgggtt gcatatattt atccttattc tggctctact      540

tcttatgccg atagcgtcaa gggccgtttc accatcagcg cggataccag caaaaacacc      600

gcatacctgc aaatgaacag cctgcgtgcg gaagataccg ccgtctatta ttgtgctcgc      660

ccggctgttc attggcatgg ttacggtggt ggttactact acggtttgga ctactggggt      720

caaggcaccc tggttaccgt gagcagc                                          747


<210>  182
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   AS48542VH5bbz

<400>  182

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365     


<210>  183
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   AS48463VH4bbz

<400>  183

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ala Asn Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ser His Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Val Ala Asp Pro Arg Ser Asn Cys Arg Gly Gly 
        115                 120                 125             


Tyr Cys Cys Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
145                 150                 155                 160 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                165                 170                 175     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            180                 185                 190         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        195                 200                 205             


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                245                 250                 255     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            260                 265                 270         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        275                 280                 285             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    290                 295                 300                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
305                 310                 315                 320 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                325                 330                 335     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            340                 345                 350         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365         


<210>  184
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   AS47863VH4bbz

<400>  184

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
        35                  40                  45              


Thr Phe Gly Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg 
        115                 120                 125             


Cys Cys Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365     


<210>  185
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   AS53574VH7bbz

<400>  185

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Ile Tyr Ser Ser Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Trp Val Ala Arg Ile His Thr Gly Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Asp Cys Ala Ala Gly Arg Val Val Leu Gly Ala Val Val 
        115                 120                 125             


Cys Thr Asn Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
145                 150                 155                 160 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                165                 170                 175     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            180                 185                 190         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        195                 200                 205             


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                245                 250                 255     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            260                 265                 270         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        275                 280                 285             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    290                 295                 300                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
305                 310                 315                 320 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                325                 330                 335     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            340                 345                 350         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365         


<210>  186
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   AS48542VH5dil-bbz

<400>  186

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Thr Ser Ala Phe Thr Phe Asp Gly Pro Asp Met 
            180                 185                 190         


Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser Ile 
        195                 200                 205             


Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Asp 
                245                 250                 255     


Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
            340                 345                 350         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        355                 360                 365             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    370                 375                 380                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg 
            500             


<210>  187
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   AS48463VH4dil-bbz

<400>  187

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ala Asn Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ser His Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Val Ala Asp Pro Arg Ser Asn Cys Arg Gly Gly 
        115                 120                 125             


Tyr Cys Cys Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Ser Asp 
            180                 185                 190         


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser 
        195                 200                 205             


Ile Ile Ser Ser His Gly Gly Thr Thr Tyr Tyr Val Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                245                 250                 255     


Ala Asp Pro Arg Ser Asn Cys Arg Gly Gly Tyr Cys Cys Gly Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                325                 330                 335     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            340                 345                 350         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        355                 360                 365             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    370                 375                 380                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
385                 390                 395                 400 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                405                 410                 415     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            420                 425                 430         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        435                 440                 445             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    450                 455                 460                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
465                 470                 475                 480 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                485                 490                 495     


Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505 


<210>  188
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863VH4dil-bbz

<400>  188

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
        35                  40                  45              


Thr Phe Gly Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg 
        115                 120                 125             


Cys Cys Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser Asp Met 
            180                 185                 190         


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser Ile 
        195                 200                 205             


Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
                245                 250                 255     


Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
            340                 345                 350         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        355                 360                 365             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    370                 375                 380                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg 
            500             


<210>  189
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542VH5-AS53574VH7bil-bbz

<400>  189

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn Cys Met 
            180                 185                 190         


Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val Ala Arg 
        195                 200                 205             


Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asp Cys Ala Ala 
                245                 250                 255     


Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210>  190
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48463VH4-AS53574VH7bil-bbz

<400>  190

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ala Asn Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ser His Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Val Ala Asp Pro Arg Ser Asn Cys Arg Gly Gly 
        115                 120                 125             


Tyr Cys Cys Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn Cys 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val Ala 
        195                 200                 205             


Arg Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asp Cys Ala 
                245                 250                 255     


Ala Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                325                 330                 335     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            340                 345                 350         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        355                 360                 365             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    370                 375                 380                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
385                 390                 395                 400 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                405                 410                 415     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            420                 425                 430         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        435                 440                 445             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    450                 455                 460                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
465                 470                 475                 480 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                485                 490                 495     


Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505 


<210>  191
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863VH4-AS53574VH7bil-bbz

<400>  191

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
        35                  40                  45              


Thr Phe Gly Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg 
        115                 120                 125             


Cys Cys Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn Cys Met 
            180                 185                 190         


Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val Ala Arg 
        195                 200                 205             


Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asp Cys Ala Ala 
                245                 250                 255     


Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210>  192
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574VH7-AS48542VH5bil-bbz

<400>  192

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Ile Tyr Ser Ser Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Trp Val Ala Arg Ile His Thr Gly Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Asp Cys Ala Ala Gly Arg Val Val Leu Gly Ala Val Val 
        115                 120                 125             


Cys Thr Asn Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe Thr Phe Asp Gly Pro Asp 
            180                 185                 190         


Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser 
        195                 200                 205             


Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu 
                245                 250                 255     


Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn Trp Gly 
            260                 265                 270         


Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210>  193
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574VH7-AS48463VH4bil-bbz

<400>  193

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Ile Tyr Ser Ser Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Trp Val Ala Arg Ile His Thr Gly Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Asp Cys Ala Ala Gly Arg Val Val Leu Gly Ala Val Val 
        115                 120                 125             


Cys Thr Asn Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Ser Asp 
            180                 185                 190         


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser 
        195                 200                 205             


Ile Ile Ser Ser His Gly Gly Thr Thr Tyr Tyr Val Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                245                 250                 255     


Ala Asp Pro Arg Ser Asn Cys Arg Gly Gly Tyr Cys Cys Gly Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                325                 330                 335     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            340                 345                 350         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        355                 360                 365             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    370                 375                 380                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
385                 390                 395                 400 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                405                 410                 415     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            420                 425                 430         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        435                 440                 445             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    450                 455                 460                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
465                 470                 475                 480 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                485                 490                 495     


Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505 


<210>  194
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574VH7-AS47863VH4bil-bbz

<400>  194

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Ile Tyr Ser Ser Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Trp Val Ala Arg Ile His Thr Gly Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Asp Cys Ala Ala Gly Arg Val Val Leu Gly Ala Val Val 
        115                 120                 125             


Cys Thr Asn Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser Asp 
            180                 185                 190         


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser 
        195                 200                 205             


Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                245                 250                 255     


Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp Gly 
            260                 265                 270         


Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            340                 345                 350         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        355                 360                 365             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    370                 375                 380                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210>  195
<211>  969
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TR2D-AS48542VH5bbz-4C

<400>  195

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe Thr Phe Asp 
            260                 265                 270         


Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu 
        275                 280                 285             


Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala 
            340                 345                 350         


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro 
        355                 360                 365             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    370                 375                 380                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
385                 390                 395                 400 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                405                 410                 415     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            420                 425                 430         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        435                 440                 445             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    450                 455                 460                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                485                 490                 495     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            500                 505                 510         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        515                 520                 525             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    530                 535                 540                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
545                 550                 555                 560 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                565                 570                 575     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
            580                 585                 590         


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
        595                 600                 605             


Pro Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile 
    610                 615                 620                 


Tyr Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys 
625                 630                 635                 640 


Glu Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser 
                645                 650                 655     


Leu Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val 
            660                 665                 670         


Leu Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu 
        675                 680                 685             


Asn Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp 
    690                 695                 700                 


Gly Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys 
705                 710                 715                 720 


Met Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe 
                725                 730                 735     


Val Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val 
            740                 745                 750         


Phe Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu 
        755                 760                 765             


Ala Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe 
    770                 775                 780                 


Ser Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr 
785                 790                 795                 800 


Ser Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn 
                805                 810                 815     


Ile Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser 
            820                 825                 830         


Met Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys 
        835                 840                 845             


Ala Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp 
    850                 855                 860                 


Thr Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu 
865                 870                 875                 880 


Val Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln 
                885                 890                 895     


Ala Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile 
            900                 905                 910         


Tyr Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe 
        915                 920                 925             


Lys Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu 
    930                 935                 940                 


Gln Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr 
945                 950                 955                 960 


Met Asp His Asp Leu His Asp Ala Leu 
                965                 


<210>  196
<211>  587
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TR2D-AS48542VH5bbz

<400>  196

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe Thr Phe Asp 
            260                 265                 270         


Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu 
        275                 280                 285             


Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala 
            340                 345                 350         


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro 
        355                 360                 365             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    370                 375                 380                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
385                 390                 395                 400 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                405                 410                 415     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            420                 425                 430         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        435                 440                 445             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    450                 455                 460                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                485                 490                 495     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            500                 505                 510         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        515                 520                 525             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    530                 535                 540                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
545                 550                 555                 560 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                565                 570                 575     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585         


<210>  197
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1CD28-AS48542VH5bbz

<400>  197

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Cys Pro Ser Pro Leu 
145                 150                 155                 160 


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
                165                 170                 175     


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            180                 185                 190         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        195                 200                 205             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    210                 215                 220                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Ser Gly Ala Thr 
225                 230                 235                 240 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                245                 250                 255     


Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
            260                 265                 270         


Leu His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala 
    290                 295                 300                 


Phe Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Cys Glu Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
            340                 345                 350         


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly 
    370                 375                 380                 


Tyr Cys Cys Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395                 400 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
                405                 410                 415     


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            420                 425                 430         


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        435                 440                 445             


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    450                 455                 460                 


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
465                 470                 475                 480 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                485                 490                 495     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            500                 505                 510         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        515                 520                 525             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    530                 535                 540                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
545                 550                 555                 560 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                565                 570                 575     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            580                 585                 590         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        595                 600                 605             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620             


<210>  198
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542VH5bbz-4C

<400>  198

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            180                 185                 190         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        195                 200                 205             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
        355                 360                 365             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    370                 375                 380                 


Asn Pro Gly Pro Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp 
385                 390                 395                 400 


Glu Ser Ile Tyr Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro 
                405                 410                 415     


Cys Thr Lys Glu Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro 
            420                 425                 430         


Leu Tyr Ser Leu Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val 
        435                 440                 445             


Val Leu Val Leu Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val 
    450                 455                 460                 


Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu 
465                 470                 475                 480 


Pro Phe Trp Gly Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly 
                485                 490                 495     


Leu Cys Lys Met Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly 
            500                 505                 510         


Ile Phe Phe Val Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val 
        515                 520                 525             


His Ala Val Phe Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile 
    530                 535                 540                 


Thr Ser Leu Ala Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly 
545                 550                 555                 560 


Phe Leu Phe Ser Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys 
                565                 570                 575     


Thr Lys Tyr Ser Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu 
            580                 585                 590         


Glu Ile Asn Ile Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe 
        595                 600                 605             


Cys Tyr Ser Met Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys 
    610                 615                 620                 


Lys Asn Lys Ala Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu 
625                 630                 635                 640 


Gly Phe Trp Thr Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val 
                645                 650                 655     


Glu Leu Glu Val Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr 
            660                 665                 670         


Ala Ile Gln Ala Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn 
        675                 680                 685             


Pro Ile Ile Tyr Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu 
    690                 695                 700                 


Gln Leu Phe Lys Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys 
705                 710                 715                 720 


Gly Leu Leu Gln Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr 
                725                 730                 735     


Gln Ser Thr Met Asp His Asp Leu His Asp Ala Leu 
            740                 745             


<210>  199
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS53574VH7

<400>  199

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Tyr Ser Ser Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Arg Ile His Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Asp Cys 
                85                  90                  95      


Ala Ala Gly Arg Val Val Leu Gly Ala Val Val Cys Thr Asn Glu Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  200
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS53574VH7 sdAb

<400>  200
gaggtgcagc tggtggagtc cggaggagga ctggtgcagc caggaggcag cctgcggctg       60

tcctgcgccg cctctggcta catctatagc tccaactgta tgggctggtt caggcaggca      120

cctggcaagg gaagggagtg ggtggccaga atccacaccg gctccggctc tacatactat      180

gccgactctg tgaagggccg gtttaccatc agccaggata actccaagaa tacactgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt atgattgcgc agcaggaagg      300

gtggtgctgg gagcagtggt gtgcacaaat gagtactggg gccagggcac cctggtgaca      360

gtgtctagc                                                              369


<210>  201
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542-28z

<400>  201

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Met Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Glu Thr Leu Arg Leu Ser Cys Thr Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Asn 
    50                  55                  60                  


Glu Cys Val Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Val Phe Leu Asn Leu Asn Ser Leu Gln Pro Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Pro Gly Thr Gln Val Thr Val Ser Ser Ile 
    130                 135                 140                 


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
145                 150                 155                 160 


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                165                 170                 175     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            180                 185                 190         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        195                 200                 205             


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
    210                 215                 220                 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
225                 230                 235                 240 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
                245                 250                 255     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            260                 265                 270         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        275                 280                 285             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    290                 295                 300                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
305                 310                 315                 320 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                325                 330                 335     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            340                 345                 350         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360         


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  202

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  203
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  amino acid no.1-5 can be repeated 4-6 times

<400>  203

Gly Gly Gly Gly Ser 
1               5  


<210>  204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  204

Ser Gly Gly Gly Ser 
1               5   


<210>  205
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TR2D-AS48542VH5dil-bbz

<400>  205

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe Thr Phe Asp 
            260                 265                 270         


Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu 
        275                 280                 285             


Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala 
            340                 345                 350         


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Thr Ser Ala Phe Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser Ile Ile Ser Ala 
            420                 425                 430         


Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        435                 440                 445             


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
    450                 455                 460                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys 
465                 470                 475                 480 


Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            500                 505                 510         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        515                 520                 525             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    530                 535                 540                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
545                 550                 555                 560 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                565                 570                 575     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            580                 585                 590         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        595                 600                 605             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    610                 615                 620                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
625                 630                 635                 640 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                645                 650                 655     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            660                 665                 670         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        675                 680                 685             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    690                 695                 700                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
705                 710                 715                 720 


Leu Pro Pro Arg 
                


<210>  206
<211>  587
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TR2D-AS47863VH4bbz

<400>  206

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly 
            260                 265                 270         


Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu 
        275                 280                 285             


Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro 
        355                 360                 365             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    370                 375                 380                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
385                 390                 395                 400 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                405                 410                 415     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            420                 425                 430         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        435                 440                 445             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    450                 455                 460                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                485                 490                 495     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            500                 505                 510         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        515                 520                 525             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    530                 535                 540                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
545                 550                 555                 560 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                565                 570                 575     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585         


<210>  207
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TR2D-AS47863VH4dil-bbz

<400>  207

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly 
            260                 265                 270         


Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu 
        275                 280                 285             


Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser Asp Met Gly Trp Tyr 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser Ile Ile Ser Ser 
            420                 425                 430         


Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile 
        435                 440                 445             


Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    450                 455                 460                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Leu Arg Gln 
465                 470                 475                 480 


Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            500                 505                 510         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        515                 520                 525             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    530                 535                 540                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
545                 550                 555                 560 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                565                 570                 575     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            580                 585                 590         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        595                 600                 605             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    610                 615                 620                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
625                 630                 635                 640 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                645                 650                 655     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            660                 665                 670         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        675                 680                 685             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    690                 695                 700                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
705                 710                 715                 720 


Leu Pro Pro Arg 
                


<210>  208
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542VH5-28z

<400>  208

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ile 
    130                 135                 140                 


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
145                 150                 155                 160 


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                165                 170                 175     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            180                 185                 190         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        195                 200                 205             


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
    210                 215                 220                 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
225                 230                 235                 240 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
                245                 250                 255     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            260                 265                 270         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        275                 280                 285             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    290                 295                 300                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
305                 310                 315                 320 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                325                 330                 335     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            340                 345                 350         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360         


<210>  209
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS48542VH5dil-28z

<400>  209

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe 
        35                  40                  45              


Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr 
        115                 120                 125             


Cys Cys Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Thr Ser Ala Phe Thr Phe Asp Gly Pro Asp Met 
            180                 185                 190         


Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser Ile 
        195                 200                 205             


Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Asp 
                245                 250                 255     


Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro 
        275                 280                 285             


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    290                 295                 300                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  210
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863VH4-28z

<400>  210

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
        35                  40                  45              


Thr Phe Gly Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg 
        115                 120                 125             


Cys Cys Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ile 
    130                 135                 140                 


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
145                 150                 155                 160 


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
                165                 170                 175     


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            180                 185                 190         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        195                 200                 205             


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
    210                 215                 220                 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
225                 230                 235                 240 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
                245                 250                 255     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            260                 265                 270         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        275                 280                 285             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    290                 295                 300                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
305                 310                 315                 320 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                325                 330                 335     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            340                 345                 350         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360         


<210>  211
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS47863VH4dil-28z

<400>  211

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
        35                  40                  45              


Thr Phe Gly Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Cys Glu Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg 
        115                 120                 125             


Cys Cys Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser Asp Met 
            180                 185                 190         


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser Ile 
        195                 200                 205             


Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
                245                 250                 255     


Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro 
        275                 280                 285             


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    290                 295                 300                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  212
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TR2D-AS48542VH5-28z

<400>  212

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe Thr Phe Asp 
            260                 265                 270         


Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu 
        275                 280                 285             


Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala 
            340                 345                 350         


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ile Glu Val Met 
        355                 360                 365             


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
    370                 375                 380                 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
385                 390                 395                 400 


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
                405                 410                 415     


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
            420                 425                 430         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        435                 440                 445             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    450                 455                 460                 


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
465                 470                 475                 480 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                485                 490                 495     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            500                 505                 510         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        515                 520                 525             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    530                 535                 540                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
545                 550                 555                 560 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                565                 570                 575     


Met Gln Ala Leu Pro Pro Arg 
            580             


<210>  213
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TR2D-AS48542VH5dil-28z

<400>  213

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Ala Phe Thr Phe Asp 
            260                 265                 270         


Gly Pro Asp Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu 
        275                 280                 285             


Leu Val Ser Ile Ile Ser Ala Asp Gly Arg Thr Tyr Tyr Ala Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Leu Asp Pro Arg Lys Asn Cys Arg Gly Gly Tyr Cys Cys Ala 
            340                 345                 350         


Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Thr Ser Ala Phe Thr Phe Asp Gly Pro Asp Met Ala Trp Tyr 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser Ile Ile Ser Ala 
            420                 425                 430         


Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        435                 440                 445             


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
    450                 455                 460                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu Asp Pro Arg Lys 
465                 470                 475                 480 


Asn Cys Arg Gly Gly Tyr Cys Cys Ala Asn Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
            500                 505                 510         


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
        515                 520                 525             


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
    530                 535                 540                 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
545                 550                 555                 560 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
                565                 570                 575     


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            580                 585                 590         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        595                 600                 605             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    610                 615                 620                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
625                 630                 635                 640 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                645                 650                 655     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            660                 665                 670         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        675                 680                 685             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    690                 695                 700                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715                 720 


<210>  214
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TR2D-AS47863VH4-28z

<400>  214

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly 
            260                 265                 270         


Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu 
        275                 280                 285             


Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ile Glu Val Met 
        355                 360                 365             


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
    370                 375                 380                 


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
385                 390                 395                 400 


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
                405                 410                 415     


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
            420                 425                 430         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        435                 440                 445             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    450                 455                 460                 


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
465                 470                 475                 480 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                485                 490                 495     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            500                 505                 510         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        515                 520                 525             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    530                 535                 540                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
545                 550                 555                 560 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                565                 570                 575     


Met Gln Ala Leu Pro Pro Arg 
            580             


<210>  215
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TR2D-AS47863VH4dil-28z

<400>  215

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        195                 200                 205             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
    210                 215                 220                 


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
225                 230                 235                 240 


Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                245                 250                 255     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly 
            260                 265                 270         


Asp Ser Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gly Cys Glu 
        275                 280                 285             


Leu Val Ser Ile Ile Ser Ser Asp Gly Arg Thr Tyr Tyr Val Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Leu 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Ala Asp Leu Arg Gln Tyr Cys Arg Asp Gly Arg Cys Cys Gly 
            340                 345                 350         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Ala Ser Gly Ser Thr Phe Gly Asp Ser Asp Met Gly Trp Tyr 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Cys Glu Leu Val Ser Ile Ile Ser Ser 
            420                 425                 430         


Asp Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile 
        435                 440                 445             


Ser Gln Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    450                 455                 460                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Leu Arg Gln 
465                 470                 475                 480 


Tyr Cys Arg Asp Gly Arg Cys Cys Gly Tyr Trp Gly Gln Gly Thr Leu 
                485                 490                 495     


Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
            500                 505                 510         


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
        515                 520                 525             


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
    530                 535                 540                 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
545                 550                 555                 560 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
                565                 570                 575     


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
            580                 585                 590         


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        595                 600                 605             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    610                 615                 620                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
625                 630                 635                 640 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                645                 650                 655     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            660                 665                 670         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        675                 680                 685             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    690                 695                 700                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715                 720 


<210>  216
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5F11 scFv

<400>  216

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln 
        115                 120                 125             


Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser 
    130                 135                 140                 


Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ala Tyr Tyr Trp Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Asp Ile 
                165                 170                 175     


Asn His Gly Gly Gly Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val 
            180                 185                 190         


Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Asn 
        195                 200                 205             


Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr 
    210                 215                 220                 


Ala Tyr Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser 
225                 230                 235         


<210>  217
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  217

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  218
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57911VH

<400>  218

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ala Leu Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  219
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57911VL

<400>  219

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Ser Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Tyr Tyr Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Pro Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  220
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57659VH

<400>  220

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Tyr Leu Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  221
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57659VL

<400>  221

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Ser Tyr Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Trp Phe Ser Tyr Pro Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  222
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57765VH

<400>  222

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Tyr Ser Leu Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  223
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS57765VL

<400>  223

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Tyr Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Tyr Pro Tyr Ser Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Ala Val His Trp His Gly Tyr Gly Gly Gly Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


