﻿                         Sequence Listing

<110>  Qyuns Therapeutics Co., Ltd.

<120>  Monoclonal Antibody Against Human Interleukin-4 Receptor Alpha and Use Thereof

<130>  FC00163PCT

<141>  2019-12-25

<150>  201811592427.X

<151>  2018-12-25

<160>  21

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<400>  1
Thr Asn Ser Met Ser 
1               5   

<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  2
Ile Ile Gly Ser Ser Gly Tyr Met Asp Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      

<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<400>  3
His Gly Asp Ser Ser Ser Phe Ala Leu 
1               5                   

<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<400>  4
Arg Ala Ser Glu Ser Val Tyr Lys Asn Asn Arg Leu Ser 
1               5                   10              

<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  5
Glu Ala Ser Lys Val Ala Ser 
1               5           

<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  6
Ala Gly Ala Tyr Arg Gly Asn Ile Tyr Pro 
1               5                   10  

<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<400>  7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Arg Thr Asn 
            20                  25                  30          
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Ile Ile Gly Ser Ser Gly Tyr Met Asp Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg His Gly Asp Ser Ser Ser Phe Ala Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  8
<211>  110
<212>  PRT
<213>  Artificial Sequence

<400>  8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Tyr Lys Asn 
            20                  25                  30          
Asn Arg Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Glu Ala Ser Lys Val Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Ala Tyr Arg Gly 
                85                  90                  95      
Asn Ile Tyr Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 

<210>  9
<211>  232
<212>  PRT
<213>  Artificial Sequence

<400>  9
Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      
Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          
Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              
Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  
Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  
Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      
Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         
Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             
Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 
Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 
Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     
Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         
Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             
Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 
Tyr Arg Glu Pro Phe Glu Gln His 
225                 230         

<210>  10
<211>  444
<212>  PRT
<213>  Artificial Sequence

<400>  10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Arg Thr Asn 
            20                  25                  30          
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Ile Ile Gly Ser Ser Gly Tyr Met Asp Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg His Gly Asp Ser Ser Ser Phe Ala Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 
Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 

<210>  11
<211>  217
<212>  PRT
<213>  Artificial Sequence

<400>  11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Tyr Lys Asn 
            20                  25                  30          
Asn Arg Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Glu Ala Ser Lys Val Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Ala Tyr Arg Gly 
                85                  90                  95      
Asn Ile Tyr Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         

<210>  12
<211>  116
<212>  PRT
<213>  Artificial Sequence

<400>  12
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asn Ser Asn 
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Phe Ile Asn Phe Ser Gly Ile Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Ser Ala Gly Ser Phe Asp Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  13
<211>  110
<212>  PRT
<213>  Artificial Sequence

<400>  13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Val Tyr Lys Asn 
            20                  25                  30          
Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Ser Ser 
                85                  90                  95      
Gly Met Tyr Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 

<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<400>  14
Ser Asn Ala Val Gly 
1               5   

<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  15
Phe Ile Asn Phe Ser Gly Ile Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      

<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<400>  16
Gly Ser Ala Gly Ser Phe Asp Leu 
1               5               

<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<400>  17
Gln Ala Ser Glu Ser Val Tyr Lys Asn Asn Tyr Leu Ala 
1               5                   10              

<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  18
Arg Ala Ser Asn Leu Ala Ser 
1               5           

<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  19
Gln Gly Gly Tyr Ser Ser Gly Met Tyr Pro 
1               5                   10  

<210>  20
<211>  443
<212>  PRT
<213>  Artificial Sequence

<400>  20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asn Ser Asn 
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Gly Phe Ile Asn Phe Ser Gly Ile Thr Tyr Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Ser Ala Gly Ser Phe Asp Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             

<210>  21
<211>  217
<212>  PRT
<213>  Artificial Sequence

<400>  21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Val Tyr Lys Asn 
            20                  25                  30          
Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Ser Ser 
                85                  90                  95      
Gly Met Tyr Pro Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         

