                         б

<110>  Ŵҩ()޹˾
 
<120>  ȫԴĿCD30弰Ӧ

<130>  PF190633PCT

<160>  169   

<170>  PatentIn version 3.3

<210>  1
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  1

Gly Phe Ile Phe Ser Ser Tyr Trp Met Ser 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  2

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  3

Ala Ser Pro Leu Trp Phe Gly Glu Ser Pro Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210>  4
<211>  122
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Trp Phe Gly Glu Ser Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  5
<211>  366
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  5
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt catctttagt agctattgga tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat    180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagccctcta    300

tggttcgggg agtcccctga tgcttttgat atctggggcc aagggacaat ggtcaccgtc    360

tcttca                                                               366


<210>  6
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  6

Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  7

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  8

Gln Gln Leu Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  9
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  9

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  10
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  10
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca    120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtcaacag cttaatagtt accctctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  11
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  11

Gly Phe Ile Phe Ser Ser Tyr Val Met Ser 
1               5                   10  


<210>  12
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  12

Glu Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  13

Ala Ser Gln Leu Asp Tyr Tyr Tyr Ala Ile Asp Val 
1               5                   10          


<210>  14
<211>  119
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Asp Tyr Tyr Tyr Ala Ile Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  15
<211>  357
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  15
gaggtgcagc tgttggagtc tgggggaggc ttggtgcagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt catttttagc agctatgtca tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagaa attagtggca gtggtggtag cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa tacgctgtat    240

ctgcaaatga acagcctggg agccgaagac tcggccatat attactgtgc gtctcagctg    300

gactactatt acgctatcga cgtctggggc caagggacca cggtcaccgt ctcttca       357


<210>  16
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  16

Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  17

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  18

Gln Gln Leu Asn Ser Tyr Pro Ile Thr 
1               5                   


<210>  19
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  19

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  20
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  20
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca    120

gggaaagccc ctaaactcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtcaacag cttaatagtt acccgatcac cttcggccaa    300

gggacacgac tggagattaa a                                              321


<210>  21
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  21

Gly Gly Ser Ile Ser Asn Thr Asn Trp Trp Ser 
1               5                   10      


<210>  22
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  22

Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  23
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  23

Ala Arg Glu Leu Gly Met Asp Phe Asp Tyr 
1               5                   10  


<210>  24
<211>  117
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Asn Thr 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Met Asp Phe Asp Tyr Trp Gly Gln Gly Met Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  25
<211>  351
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  25
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc     60

acctgcgctg tctctggtgg ctccatcagc aatactaact ggtggagttg ggtccgccag    120

tccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccaactac    180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc    240

ctgaagctga gctctgtgac cgccgcggac acggccgtgt attactgtgc gagagaactg    300

gggatggact ttgactactg gggccaggga atgttggtca ccgtctcctc a             351


<210>  26
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  26

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  27
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  27

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  28

Met Gln Ala Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  29
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  29

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  30
<211>  336
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  30
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atctcctgca ggtctagtca gagcctccta catagtaatg gatacaacta tttggattgg    120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc    180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc    240

agcagagtgg aggctgagga tattggggtt tattactgca tgcaagctct acaaactccg    300

tacacttttg gccaggggac caagctggag atcaaa                              336


<210>  31
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  31

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  32
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  32

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  33

Val Arg Asp Leu Gly Asp Tyr 
1               5           


<210>  34
<211>  114
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Leu Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  35
<211>  342
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  35
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cgtctggatt caccttcagt agttatggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atctggtatg atggaagtaa taaatattat    180

gcagactccg tgaagggccg actcaccatc tccagagaca actccaagaa tatgttgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgt gagagatctg    300

ggggactact ggggccaggg aaccctggtc accgtctcct ca                       342


<210>  36
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  36

Arg Ser Ser Gln Ser Leu Val Tyr Ile Asn Gly Asn Thr Phe Leu Asn 
1               5                   10                  15      


<210>  37
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  37

Lys Val Ser Asn Arg Asp Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  38

Met Gln Gly Thr His Trp Pro Ile Thr 
1               5                   


<210>  39
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  39

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ile 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Ile Thr Leu Gly Gln Gly Thr Arg Leu Glu Ile Thr 
            100                 105                 110         


<210>  40
<211>  336
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  40
gatgttgtga tgacgcagtc tccactctcc ctgtccgtca cccttggaca gccggcctcc     60

atctcctgca ggtctagtca aagcctcgta tacattaatg gaaacacctt cttgaattgg    120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac    180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc    240

agcagggtgg aggctgagga tgttgggatt tattactgca tgcaaggtac acactggcct    300

atcaccctcg gccaagggac acgactggag attaca                              336


<210>  41
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  41

Gly Phe Thr Phe Gly Asn Tyr Ala Met Thr 
1               5                   10  


<210>  42
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  42

Ala Ile Ser Gly Asp Gly Val Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  43

Ala Lys Gly Gly Phe Gly Asp Pro Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  44
<211>  124
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Asp Gly Val Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Phe Gly Asp Pro Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  45
<211>  372
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  45
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttggc aactatgcca tgacctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggtg atggtgttac cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac tcggccgtat attactgtgc gaaaggaggg    300

tttggggacc cctactacta ctactacggt atggacgtct ggggccaagg gaccacggtc    360

accgtctcct ca                                                        372


<210>  46
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  46

Arg Ala Ser Gln Ser Ile Ser Ser 
1               5               


<210>  47
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  47

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  48
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  48

Gln Gln Tyr Asn Ser Tyr Trp Thr 
1               5               


<210>  49
<211>  106
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  50
<211>  318
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  50
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct    240

gatgattttg caacttatta ctgccaacag tataatagtt attggacgtt cggccaaggg    300

accaaggtgg aaatcaaa                                                  318


<210>  51
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  51

Gly Ile Thr Ile Arg Asp Ser Gly Met His 
1               5                   10  


<210>  52
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  52

Val Ile Tyr Tyr Val Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  53

Ala Arg Trp Gly Ser Gly Thr Tyr Tyr Asn Leu Ile Leu Phe Asp Tyr 
1               5                   10                  15      


<210>  54
<211>  123
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  54

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ile Thr Ile Arg Asp Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Tyr Val Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Ser Gly Thr Tyr Tyr Asn Leu Ile Leu Phe Asp Tyr 
            100                 105                 110         


Arg Asp Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  55
<211>  369
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  55
caggtgcaac tggtggagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc     60

tcctgtgcaa cgtctggaat caccatcaga gactctggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atttactatg ttggaagtaa aaaatactat    180

gcagactccg tgaggggccg attcaccatc tccagggaca attcctcgaa ctcgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagatggggt    300

tcgggaactt attataacct aatcctcttt gactaccggg accagggaac cctggtcacc    360

gtctcctca                                                            369


<210>  56
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  56

Arg Ala Ser Gln Ser Ile Ser Asn 
1               5               


<210>  57
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  57

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  58
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  58

Gln Gln Tyr Asn Thr Tyr Trp Thr 
1               5               


<210>  59
<211>  106
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Asn Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  60
<211>  318
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  60
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggccagtca gagtattagt aattggttgg cctggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcggcaa cctgcagcct    240

gatgattttg caacttatta ctgccaacag tataatactt attggacgtt cggccagggg    300

accaaggtgg aaatcaaa                                                  318


<210>  61
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  61

Gly Phe Thr Phe Ser Asn Tyr Ser Met Ser 
1               5                   10  


<210>  62
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  62

Ala Ile Ser Gly Ser Gly Gly Gly Ala Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  63

Val Lys Asp Leu Leu Leu His Ile 
1               5               


<210>  64
<211>  115
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  64

Glu Val His Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Ala Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Leu Leu Leu His Ile Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  65
<211>  345
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  65
gaggtgcacc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgacactc     60

tcctgtgcag cctcaggatt cacctttagc aactattcca tgagttgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctccgct attagtggta gtggtggtgg cgcaaaatac    180

gctgactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga accgcctgag agccgaggac acggccgtct attactgtgt gaaagattta    300

ttactgcata tctggggcca agggacaatg gtcaccgtct cttca                    345


<210>  66
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  66

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  67
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  67

Met Val Ser Asn Arg Asp Ser 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  68

Met Gln Gly Thr His Trp Pro Phe Thr 
1               5                   


<210>  69
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  69

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Met Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210>  70
<211>  336
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  70
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc     60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg    120

tttcagcaga ggccaggcca atctccaagg cgcctaattt atatggtttc taaccgggac    180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc    240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcca    300

ttcactttcg gccctgggac caaagtggat atcaaa                              336


<210>  71
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  71

Gly Asp Thr Phe Ser Asn Tyr Ala Ile Ser 
1               5                   10  


<210>  72
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  72

Gly Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  73
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  73

Ala Ile Asp Pro Gly Phe Asp Tyr 
1               5               


<210>  74
<211>  115
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Ile Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Asp Pro Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  75
<211>  345
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  75
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc     60

tcctgcaagg cttctggaga caccttcagc aactatgcta tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tccttggtac agcaaactac    180

gcacagaagt tccaggacag agtcacgatt atcgcggaca aatccacgag cacagcctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gatagatccg    300

gggtttgact actggggcca gggaaccctg gtcaccgtct cctca                    345


<210>  76
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  76

Arg Ser Ser Gln Ser Leu Leu His Arg Asn Gly Tyr Asn Tyr Leu Asn 
1               5                   10                  15      


<210>  77
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  77

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  78
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  78

Met Gln Asp Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  79
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  79

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asn Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Asp Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Met Gln Asp 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Arg 
            100                 105                 110         


<210>  80
<211>  336
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  80
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atctcctgca ggtctagtca gagcctcctg catagaaatg gatacaacta tttgaattgg    120

ttcctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc    180

tccggggtcc ctgacaggtt tagtggcagt gattcaggca cagattttac actgaaaatc    240

agcagagtgg aggctgagga tgttgggttt tattactgca tgcaagatct acaaactccg    300

tacacttttg gccaggggac caagctggag atcaga                              336


<210>  81
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  81

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  82
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  82

Val Ile Trp Tyr Asp Gly Ser Asn Lys Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  18
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  83

Ala Lys Trp Gly Ser Ser Ser Trp Glu Ala Asn Phe Cys Asn Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  84
<211>  125
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  84

Gln Val Gln Leu Val Asp Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Gly Ser Ser Ser Trp Glu Ala Asn Phe Cys Asn Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120                 125 


<210>  85
<211>  375
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  85
caggtgcagc tggtggactc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaaaagtat    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgttgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaaatggggt    300

agtagcagct gggaggccaa cttctgcaac ggtatggacg tctggggcca agggaccgcg    360

gtcaccgtct cctca                                                     375


<210>  86
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  86

Arg Ala Ser Gln Asn Ile Ser Ser Asn Leu Asp 
1               5                   10      


<210>  87
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  87

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  88
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  88

Gln Gln Tyr Asn Asn Trp Pro Leu Thr 
1               5                   


<210>  89
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  89

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Ser Ser Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  90
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  90
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gaatattagc agcaacttag actggtatca gcagaaacct    120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tattccagcc    180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct    240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  91
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  91

Gly Phe Ile Phe Ser Ser Tyr Trp Met Ser 
1               5                   10  


<210>  92
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  92

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  93

Ala Ser Pro Leu Trp Phe Gly Glu Ser Pro Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210>  94
<211>  122
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Trp Phe Gly Glu Ser Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  95
<211>  366
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  95
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc     60

tcctgtacag cctctggatt catctttagt agctattgga tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtggccaat ataaagcaag atggaagtga gaaatactat    180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat    240

ctgcaaatga acagtctgag agccgaggac acggctgtgt attactgtgc gagccctcta    300

tggttcggag agtcccctga tgcttttgat atctggggcc aagggacaat ggtcaccgtc    360

tcttca                                                               366


<210>  96
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  96

Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  97
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  97

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  98
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  98

Gln Gln Leu Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  99
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  99

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  100
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  100
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca    120

gggaaagccc ctaagttcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtcaacag cttaatagtt accctctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  101
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  101

Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   10  


<210>  102
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  102

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  103

Ala Arg Arg Tyr Leu Pro Thr Ala Ala Ser Gly Phe Asp Tyr 
1               5                   10                  


<210>  104
<211>  121
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  104

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Leu Pro Thr Ala Ala Ser Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  105
<211>  363
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  105
caggtgcagc tggtgcagag cggcgccgag gtgaaaaaac ctggcgccag cgtgaaagtg     60

agctgcaagg ccagcggcta caccttcacc agctactaca tgcactgggt gcgccaggca    120

cctggtcagg gtctggagtg gatgggcatc atcaacccta gcggcggtag caccagctat    180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat    240

atggagctga gcagcctgcg cagcgaggat accgccgtgt attactgcgc ccgtcgctat    300

ctgcctaccg ccgccagcgg cttcgattat tggggtcagg gcaccctggt gacagtgagc    360

agc                                                                  363


<210>  106
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  106

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  107
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  107

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  108
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  108

Gln Gln Ser Tyr Asn Tyr Pro Leu Thr 
1               5                   


<210>  109
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  109

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  110
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  110
gagatcgtga tgacccagag ccctgccacc ctgagcgtta gccctggcga acgcgccacc     60

ctgtcttgtc gcgccagcca gagcgtgagc agcaatctgg cctggtatca gcagaaacct    120

ggccaggccc ctcgcctgct gatctatggc gcctctacac gcgccacagg catccctgcc    180

cgtttttctg gcagcggcag cggcaccgag tttaccctga ccatcagcag cctgcagagc    240

gaggatttcg ccgtgtacta ctgccagcag agctataatt atcctctgac ttttggtggc    300

ggtaccaaag tggaaattaa a                                              321


<210>  111
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  111

Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser 
1               5                   10  


<210>  112
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  112

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  113
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  113

Ala Arg Val Gly Ser Val Thr Pro Glu Gly Ser Asp Pro 
1               5                   10              


<210>  114
<211>  120
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  114

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Ser Val Thr Pro Glu Gly Ser Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  115
<211>  360
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  115
caggtgcagc tggtgcagtc tggcgccgag gtgaaaaaac ctggcgccag cgttaaggtg     60

agctgcaaag ccagcggcta taccttcacc agctatggca tcagctgggt gcgccaggca    120

cctggtcagg gtctggaatg gatgggctgg atcagcgcct acaacggcaa caccaattac    180

gcccagaaac tgcagggccg cgtgacaatg accaccgata ccagcaccag caccgcctat    240

atggagctgc gtagcctgcg cagcgatgat accgccgtgt attactgcgc ccgtgtgggc    300

agcgtgaccc ctgagggcag cgatccttgg ggtcagggca ccctggtgac agtgagcagc    360


<210>  116
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  116

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  117
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  117

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  118
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  118

Gln Gln Arg Gly Ser Trp Pro Trp Thr 
1               5                   


<210>  119
<211>  108
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  119

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Gly Ser Trp Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  120
<211>  324
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  120
gagatcgtgc tgacccagag ccctggcaca ctgagcctga gccctggcga acgcgccaca     60

ctgagctgtc gcgccagcca gagcgtgagc agcagctatc tggcctggta tcagcagaag    120

cctggccagg ccccacgtct gctgatttat ggcgccagca gccgcgccac cggcattcct    180

gatcgctttt ctggcagcgg cagcggcacc gattttaccc tgaccatcag ccgcctggag    240

cctgaagact tcgccgtgta ctactgccag cagcgcggca gctggccttg gacttttggt    300

ggcggtacca aagtggagat caaa                                           324


<210>  121
<211>  244
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Trp Phe Gly Glu Ser Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Leu Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  122
<211>  732
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  122
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt catctttagt agctattgga tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat    180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagccctcta    300

tggttcgggg agtcccctga tgcttttgat atctggggcc aagggacaat ggtcaccgtc    360

tcttcaggag gcggaggatc tggtggcgga ggaagcggtg gcggcggatc agacatccag    420

ttgacccagt ctccatcctt cctgtctgca tctgtaggag acagagtcac catcacttgc    480

cgggccagtc agggcattag cagttattta gcctggtatc agcaaaaacc agggaaagcc    540

cctaagctcc tgatctatgc tgcatccact ttgcaaagtg gggtcccatc aaggttcagc    600

ggcagtggat ctgggacaga attcactctc acaatcagca gcctgcagcc tgaagatttt    660

gcaacttatt actgtcaaca gcttaatagt taccctctca ctttcggcgg agggaccaag    720

gtggagatca aa                                                        732


<210>  123
<211>  516
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Trp Phe Gly Glu Ser Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Leu Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    290                 295                 300                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
305                 310                 315                 320 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                325                 330                 335     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            340                 345                 350         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        355                 360                 365             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    370                 375                 380                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
385                 390                 395                 400 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                405                 410                 415     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            420                 425                 430         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        435                 440                 445             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    450                 455                 460                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
465                 470                 475                 480 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                485                 490                 495     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            500                 505                 510         


Ser Pro Gly Lys 
        515     


<210>  124
<211>  241
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  124

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Asp Tyr Tyr Tyr Ala Ile Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Leu Asn Ser Tyr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  125
<211>  723
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  125
gaggtgcagc tgttggagtc tgggggaggc ttggtgcagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt catttttagc agctatgtca tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagaa attagtggca gtggtggtag cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa tacgctgtat    240

ctgcaaatga acagcctggg agccgaagac tcggccatat attactgtgc gtctcagctg    300

gactactatt acgctatcga cgtctggggc caagggacca cggtcaccgt ctcttcagga    360

ggcggaggat ctggtggcgg aggaagcggt ggcggcggat cagacatcca gttgacccag    420

tctccatcct tcctgtctgc atctgtagga gacagagtca ccatcacttg ccgggccagt    480

cagggcatta gcagttattt agcctggtat cagcaaaaac cagggaaagc ccctaaactc    540

ctgatctatg ctgcatccac tttgcaaagt ggggtcccat caaggttcag cggcagtgga    600

tctgggacag aattcactct cacaatcagc agcctgcagc ctgaagattt tgcaacttat    660

tactgtcaac agcttaatag ttacccgatc accttcggcc aagggacacg actggagatt    720

aaa                                                                  723


<210>  126
<211>  513
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  126

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Leu Asp Tyr Tyr Tyr Ala Ile Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Leu Asn Ser Tyr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
225                 230                 235                 240 


Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Asp Lys 
        275                 280                 285             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    290                 295                 300                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
305                 310                 315                 320 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                325                 330                 335     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            340                 345                 350         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        355                 360                 365             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
385                 390                 395                 400 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                405                 410                 415     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            420                 425                 430         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        435                 440                 445             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    450                 455                 460                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
465                 470                 475                 480 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                485                 490                 495     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 505                 510         


Lys 
    


<210>  127
<211>  244
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  127

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Asn Thr 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Met Asp Phe Asp Tyr Trp Gly Gln Gly Met Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Met Gln Ala Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  128
<211>  732
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  128
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc     60

acctgcgctg tctctggtgg ctccatcagc aatactaact ggtggagttg ggtccgccag    120

tccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccaactac    180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc    240

ctgaagctga gctctgtgac cgccgcggac acggccgtgt attactgtgc gagagaactg    300

gggatggact ttgactactg gggccaggga atgttggtca ccgtctcctc aggaggcgga    360

ggatctggtg gcggaggaag cggtggcggc ggatcagata ttgtgatgac tcagtctcca    420

ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtcagagc    480

ctcctacata gtaatggata caactatttg gattggtacc tgcagaagcc agggcagtct    540

ccacagctcc tgatctattt gggttctaat cgggcctccg gggtccctga caggttcagt    600

ggcagtggat caggcacaga ttttacactg aaaatcagca gagtggaggc tgaggatatt    660

ggggtttatt actgcatgca agctctacaa actccgtaca cttttggcca ggggaccaag    720

ctggagatca aa                                                        732


<210>  129
<211>  516
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  129

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Asn Thr 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Gly Met Asp Phe Asp Tyr Trp Gly Gln Gly Met Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Ile Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Met Gln Ala Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    290                 295                 300                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
305                 310                 315                 320 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                325                 330                 335     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            340                 345                 350         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        355                 360                 365             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    370                 375                 380                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
385                 390                 395                 400 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                405                 410                 415     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            420                 425                 430         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        435                 440                 445             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    450                 455                 460                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
465                 470                 475                 480 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                485                 490                 495     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            500                 505                 510         


Ser Pro Gly Lys 
        515     


<210>  130
<211>  241
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  130

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Leu Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu 
    130                 135                 140                 


Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr 
145                 150                 155                 160 


Ile Asn Gly Asn Thr Phe Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln 
                165                 170                 175     


Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
        195                 200                 205             


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln 
    210                 215                 220                 


Gly Thr His Trp Pro Ile Thr Leu Gly Gln Gly Thr Arg Leu Glu Ile 
225                 230                 235                 240 


Thr 
    


<210>  131
<211>  723
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  131
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cgtctggatt caccttcagt agttatggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atctggtatg atggaagtaa taaatattat    180

gcagactccg tgaagggccg actcaccatc tccagagaca actccaagaa tatgttgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgt gagagatctg    300

ggggactact ggggccaggg aaccctggtc accgtctcct caggaggcgg aggatctggt    360

ggcggaggaa gcggtggcgg cggatcagat gttgtgatga cgcagtctcc actctccctg    420

tccgtcaccc ttggacagcc ggcctccatc tcctgcaggt ctagtcaaag cctcgtatac    480

attaatggaa acaccttctt gaattggttt cagcagaggc caggccaatc tccaaggcgc    540

ctaatttata aggtttctaa ccgggactct ggggtcccag acagattcag cggcagtggg    600

tcaggcactg atttcacact gaaaatcagc agggtggagg ctgaggatgt tgggatttat    660

tactgcatgc aaggtacaca ctggcctatc accctcggcc aagggacacg actggagatt    720

aca                                                                  723


<210>  132
<211>  513
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  132

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Leu Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu 
    130                 135                 140                 


Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr 
145                 150                 155                 160 


Ile Asn Gly Asn Thr Phe Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln 
                165                 170                 175     


Ser Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
        195                 200                 205             


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln 
    210                 215                 220                 


Gly Thr His Trp Pro Ile Thr Leu Gly Gln Gly Thr Arg Leu Glu Ile 
225                 230                 235                 240 


Thr Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Asp Lys 
        275                 280                 285             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    290                 295                 300                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
305                 310                 315                 320 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                325                 330                 335     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            340                 345                 350         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        355                 360                 365             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
385                 390                 395                 400 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                405                 410                 415     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            420                 425                 430         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        435                 440                 445             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    450                 455                 460                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
465                 470                 475                 480 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                485                 490                 495     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 505                 510         


Lys 
    


<210>  133
<211>  245
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  133

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Asp Gly Val Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Phe Gly Asp Pro Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  134
<211>  735
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  134
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttggc aactatgcca tgacctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggtg atggtgttac cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac tcggccgtat attactgtgc gaaaggaggg    300

tttggggacc cctactacta ctactacggt atggacgtct ggggccaagg gaccacggtc    360

accgtctcct caggaggcgg aggatctggt ggcggaggaa gcggtggcgg cggatcagac    420

atccagatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc    480

acttgccggg ccagtcagag tattagtagc tggttggcct ggtatcagca gaaaccaggg    540

aaagccccta agctcctgat ctataaggcg tctagtttag aaagtggggt cccatcaagg    600

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat    660

gattttgcaa cttattactg ccaacagtat aatagttatt ggacgttcgg ccaagggacc    720

aaggtggaaa tcaaa                                                     735


<210>  135
<211>  517
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  135

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Asp Gly Val Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Phe Gly Asp Pro Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser 
            180                 185                 190         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    290                 295                 300                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
305                 310                 315                 320 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                325                 330                 335     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            340                 345                 350         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        355                 360                 365             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                405                 410                 415     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            420                 425                 430         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        435                 440                 445             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    450                 455                 460                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
465                 470                 475                 480 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                485                 490                 495     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            500                 505                 510         


Leu Ser Pro Gly Lys 
        515         


<210>  136
<211>  244
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  136

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ile Thr Ile Arg Asp Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Tyr Val Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Ser Gly Thr Tyr Tyr Asn Leu Ile Leu Phe Asp Tyr 
            100                 105                 110         


Arg Asp Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu 
            180                 185                 190         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
        195                 200                 205             


Phe Thr Leu Thr Ile Gly Asn Leu Gln Pro Asp Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Asn Thr Tyr Trp Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  137
<211>  732
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  137
caggtgcaac tggtggagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc     60

tcctgtgcaa cgtctggaat caccatcaga gactctggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atttactatg ttggaagtaa aaaatactat    180

gcagactccg tgaggggccg attcaccatc tccagggaca attcctcgaa ctcgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagatggggt    300

tcgggaactt attataacct aatcctcttt gactaccggg accagggaac cctggtcacc    360

gtctcctcag gaggcggagg atctggtggc ggaggaagcg gtggcggcgg atcagacatc    420

cagatgaccc agtctccttc caccctgtct gcatctgtag gagacagagt caccatcact    480

tgccgggcca gtcagagtat tagtaattgg ttggcctggt atcagcagaa accagggaaa    540

gcccctaagc tcctgatcta taaggcgtct agtttagaaa gtggggtccc atcaaggttc    600

agcggcagtg gatctgggac agaattcact ctcacaatcg gcaacctgca gcctgatgat    660

tttgcaactt attactgcca acagtataat acttattgga cgttcggcca ggggaccaag    720

gtggaaatca aa                                                        732


<210>  138
<211>  516
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  138

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ile Thr Ile Arg Asp Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Tyr Val Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Ser Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Ser Gly Thr Tyr Tyr Asn Leu Ile Leu Phe Asp Tyr 
            100                 105                 110         


Arg Asp Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu 
            180                 185                 190         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
        195                 200                 205             


Phe Thr Leu Thr Ile Gly Asn Leu Gln Pro Asp Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Asn Thr Tyr Trp Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    290                 295                 300                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
305                 310                 315                 320 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                325                 330                 335     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            340                 345                 350         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        355                 360                 365             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    370                 375                 380                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
385                 390                 395                 400 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                405                 410                 415     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            420                 425                 430         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        435                 440                 445             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    450                 455                 460                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
465                 470                 475                 480 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                485                 490                 495     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            500                 505                 510         


Ser Pro Gly Lys 
        515     


<210>  139
<211>  242
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  139

Glu Val His Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Ala Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Leu Leu Leu His Ile Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
    130                 135                 140                 


Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


Tyr Ser Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly 
                165                 170                 175     


Gln Ser Pro Arg Arg Leu Ile Tyr Met Val Ser Asn Arg Asp Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
    210                 215                 220                 


Gln Gly Thr His Trp Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp 
225                 230                 235                 240 


Ile Lys 
        


<210>  140
<211>  726
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  140
gaggtgcacc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgacactc     60

tcctgtgcag cctcaggatt cacctttagc aactattcca tgagttgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctccgct attagtggta gtggtggtgg cgcaaaatac    180

gctgactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga accgcctgag agccgaggac acggccgtct attactgtgt gaaagattta    300

ttactgcata tctggggcca agggacaatg gtcaccgtct cttcaggagg cggaggatct    360

ggtggcggag gaagcggtgg cggcggatca gatgttgtga tgactcagtc tccactctcc    420

ctgcccgtca cccttggaca gccggcctcc atctcctgca ggtctagtca aagcctcgta    480

tacagtgatg gaaacaccta cttgaattgg tttcagcaga ggccaggcca atctccaagg    540

cgcctaattt atatggtttc taaccgggac tctggggtcc cagacagatt cagcggcagt    600

gggtcaggca ctgatttcac actgaaaatc agcagggtgg aggctgagga tgttggggtt    660

tattactgca tgcaaggtac acactggcca ttcactttcg gccctgggac caaagtggat    720

atcaaa                                                               726


<210>  141
<211>  514
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  141

Glu Val His Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Ala Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Leu Leu Leu His Ile Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
    130                 135                 140                 


Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


Tyr Ser Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly 
                165                 170                 175     


Gln Ser Pro Arg Arg Leu Ile Tyr Met Val Ser Asn Arg Asp Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
    210                 215                 220                 


Gln Gly Thr His Trp Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp 
225                 230                 235                 240 


Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Asp 
        275                 280                 285             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    290                 295                 300                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
305                 310                 315                 320 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                325                 330                 335     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            340                 345                 350         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        355                 360                 365             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    370                 375                 380                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
385                 390                 395                 400 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                405                 410                 415     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            420                 425                 430         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        435                 440                 445             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    450                 455                 460                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
465                 470                 475                 480 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                485                 490                 495     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            500                 505                 510         


Gly Lys 
        


<210>  142
<211>  242
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  142

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Ile Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Asp Pro Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
    130                 135                 140                 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
145                 150                 155                 160 


His Arg Asn Gly Tyr Asn Tyr Leu Asn Trp Phe Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Asp Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Met 
    210                 215                 220                 


Gln Asp Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Arg 
        


<210>  143
<211>  726
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  143
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc     60

tcctgcaagg cttctggaga caccttcagc aactatgcta tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tccttggtac agcaaactac    180

gcacagaagt tccaggacag agtcacgatt atcgcggaca aatccacgag cacagcctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gatagatccg    300

gggtttgact actggggcca gggaaccctg gtcaccgtct cctcaggagg cggaggatct    360

ggtggcggag gaagcggtgg cggcggatca gatattgtga tgactcagtc tccactctcc    420

ctgcccgtca cccctggaga gccggcctcc atctcctgca ggtctagtca gagcctcctg    480

catagaaatg gatacaacta tttgaattgg ttcctgcaga agccagggca gtctccacag    540

ctcctgatct atttgggttc taatcgggcc tccggggtcc ctgacaggtt tagtggcagt    600

gattcaggca cagattttac actgaaaatc agcagagtgg aggctgagga tgttgggttt    660

tattactgca tgcaagatct acaaactccg tacacttttg gccaggggac caagctggag    720

atcaga                                                               726


<210>  144
<211>  514
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  144

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Ile Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Asp Pro Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr 
    130                 135                 140                 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
145                 150                 155                 160 


His Arg Asn Gly Tyr Asn Tyr Leu Asn Trp Phe Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Asp Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Met 
    210                 215                 220                 


Gln Asp Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Asp 
        275                 280                 285             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    290                 295                 300                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
305                 310                 315                 320 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                325                 330                 335     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            340                 345                 350         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        355                 360                 365             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    370                 375                 380                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
385                 390                 395                 400 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                405                 410                 415     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            420                 425                 430         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        435                 440                 445             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    450                 455                 460                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
465                 470                 475                 480 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                485                 490                 495     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            500                 505                 510         


Gly Lys 
        


<210>  145
<211>  247
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  145

Gln Val Gln Leu Val Asp Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Gly Ser Ser Ser Trp Glu Ala Asn Phe Cys Asn Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asn Ile Ser Ser Asn Leu Asp Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
            180                 185                 190         


Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  146
<211>  741
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  146
caggtgcagc tggtggactc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaaaagtat    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgttgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaaatggggt    300

agtagcagct gggaggccaa cttctgcaac ggtatggacg tctggggcca agggaccgcg    360

gtcaccgtct cctcaggagg cggaggatct ggtggcggag gaagcggtgg cggcggatca    420

gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc    480

ctctcctgca gggccagtca gaatattagc agcaacttag actggtatca gcagaaacct    540

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tattccagcc    600

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct    660

gaagattttg cagtttatta ctgtcagcag tataataact ggcctctcac tttcggcgga    720

gggaccaagg tggagatcaa a                                              741


<210>  147
<211>  519
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  147

Gln Val Gln Leu Val Asp Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Gly Ser Ser Ser Trp Glu Ala Asn Phe Cys Asn Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asn Ile Ser Ser Asn Leu Asp Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
            180                 185                 190         


Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    290                 295                 300                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
305                 310                 315                 320 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                325                 330                 335     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            340                 345                 350         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        355                 360                 365             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    370                 375                 380                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
385                 390                 395                 400 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                405                 410                 415     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            420                 425                 430         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        435                 440                 445             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    450                 455                 460                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
465                 470                 475                 480 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                485                 490                 495     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            500                 505                 510         


Leu Ser Leu Ser Pro Gly Lys 
        515                 


<210>  148
<211>  244
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Trp Phe Gly Glu Ser Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Phe Leu Ile Tyr Ala Ala Ser Thr Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Leu Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  149
<211>  732
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  149
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc     60

tcctgtacag cctctggatt catctttagt agctattgga tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtggccaat ataaagcaag atggaagtga gaaatactat    180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat    240

ctgcaaatga acagtctgag agccgaggac acggctgtgt attactgtgc gagccctcta    300

tggttcggag agtcccctga tgcttttgat atctggggcc aagggacaat ggtcaccgtc    360

tcttcaggag gcggaggatc tggtggcgga ggaagcggtg gcggcggatc agacatccag    420

ttgacccagt ctccatcctt cctgtctgca tctgtaggag acagagtcac catcacttgc    480

cgggccagtc agggcattag cagttattta gcctggtatc agcaaaaacc agggaaagcc    540

cctaagttcc tgatctatgc tgcatccact ttgcaaagtg gggtcccatc aaggttcagc    600

ggcagtggat ctgggacaga attcactctc acaatcagca gcctgcagcc tgaagatttt    660

gcaacttatt actgtcaaca gcttaatagt taccctctca ctttcggcgg agggaccaag    720

gtggagatca aa                                                        732


<210>  150
<211>  516
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Trp Phe Gly Glu Ser Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Phe Leu Ile Tyr Ala Ala Ser Thr Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Leu Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    290                 295                 300                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
305                 310                 315                 320 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                325                 330                 335     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            340                 345                 350         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        355                 360                 365             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    370                 375                 380                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
385                 390                 395                 400 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                405                 410                 415     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            420                 425                 430         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        435                 440                 445             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    450                 455                 460                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
465                 470                 475                 480 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                485                 490                 495     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            500                 505                 510         


Ser Pro Gly Lys 
        515     


<210>  151
<211>  243
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  151

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Leu Pro Thr Ala Ala Ser Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  152
<211>  729
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  152
caggtgcagc tggtgcagag cggcgccgag gtgaaaaaac ctggcgccag cgtgaaagtg     60

agctgcaagg ccagcggcta caccttcacc agctactaca tgcactgggt gcgccaggca    120

cctggtcagg gtctggagtg gatgggcatc atcaacccta gcggcggtag caccagctat    180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat    240

atggagctga gcagcctgcg cagcgaggat accgccgtgt attactgcgc ccgtcgctat    300

ctgcctaccg ccgccagcgg cttcgattat tggggtcagg gcaccctggt gacagtgagc    360

agcggaggcg gaggatctgg tggcggagga agcggtggcg gcggatcaga gatcgtgatg    420

acccagagcc ctgccaccct gagcgttagc cctggcgaac gcgccaccct gtcttgtcgc    480

gccagccaga gcgtgagcag caatctggcc tggtatcagc agaaacctgg ccaggcccct    540

cgcctgctga tctatggcgc ctctacacgc gccacaggca tccctgcccg tttttctggc    600

agcggcagcg gcaccgagtt taccctgacc atcagcagcc tgcagagcga ggatttcgcc    660

gtgtactact gccagcagag ctataattat cctctgactt ttggtggcgg taccaaagtg    720

gaaattaaa                                                            729


<210>  153
<211>  515
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  153

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Leu Pro Thr Ala Ala Ser Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        355                 360                 365             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys 
        515 


<210>  154
<211>  243
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  154

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Ser Val Thr Pro Glu Gly Ser Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Gly Ser Trp Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  155
<211>  729
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  155
caggtgcagc tggtgcagtc tggcgccgag gtgaaaaaac ctggcgccag cgttaaggtg     60

agctgcaaag ccagcggcta taccttcacc agctatggca tcagctgggt gcgccaggca    120

cctggtcagg gtctggaatg gatgggctgg atcagcgcct acaacggcaa caccaattac    180

gcccagaaac tgcagggccg cgtgacaatg accaccgata ccagcaccag caccgcctat    240

atggagctgc gtagcctgcg cagcgatgat accgccgtgt attactgcgc ccgtgtgggc    300

agcgtgaccc ctgagggcag cgatccttgg ggtcagggca ccctggtgac agtgagcagc    360

ggaggcggag gatctggtgg cggaggaagc ggtggcggcg gatcagagat cgtgctgacc    420

cagagccctg gcacactgag cctgagccct ggcgaacgcg ccacactgag ctgtcgcgcc    480

agccagagcg tgagcagcag ctatctggcc tggtatcagc agaagcctgg ccaggcccca    540

cgtctgctga tttatggcgc cagcagccgc gccaccggca ttcctgatcg cttttctggc    600

agcggcagcg gcaccgattt taccctgacc atcagccgcc tggagcctga agacttcgcc    660

gtgtactact gccagcagcg cggcagctgg ccttggactt ttggtggcgg taccaaagtg    720

gagatcaaa                                                            729


<210>  156
<211>  515
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  156

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Ser Val Thr Pro Glu Gly Ser Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Gly Ser Trp Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        355                 360                 365             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys 
        515 


<210>  157
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  ͷ

<400>  157

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  158
<211>  45
<212>  DNA
<213>  ˹

<220>
<223>  ͷDNA

<400>  158
ggaggcggag gatctggtgg cggaggaagc ggtggcggcg gatca                     45


<210>  159
<211>  45
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  159

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  160
<211>  135
<212>  DNA
<213>  ˹

<220>
<223>  DNA 

<400>  160
accacaacac cagcccctag acctcctacc ccagctccta caatcgcctc tcagcctctg     60

agcctgagac ccgaggcctg cagaccagcc gcaggaggag cagtgcatac aagaggcctg    120

gatttcgctt gcgac                                                     135


<210>  161
<211>  227
<212>  PRT
<213>  ˹

<220>
<223>  IgG1 Fc 

<400>  161

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  162
<211>  595
<212>  PRT
<213>  ˹

<220>
<223>  CD30ȫ

<400>  162

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Arg Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  163
<211>  361
<212>  PRT
<213>  ˹

<220>
<223>  CD30 ECD 

<400>  163

Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn Pro Ser 
1               5                   10                  15      


His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys Pro Met 
            20                  25                  30          


Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp Cys Arg 
        35                  40                  45              


Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg Cys Thr 
    50                  55                  60                  


Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro Cys 
65                  70                  75                  80  


Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met Phe Cys 
                85                  90                  95      


Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His Ser Val 
            100                 105                 110         


Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln Lys Asn 
        115                 120                 125             


Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys Ala Ser 
    130                 135                 140                 


Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln Ala Lys 
145                 150                 155                 160 


Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met Pro Val 
                165                 170                 175     


Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu Thr Arg 
            180                 185                 190         


Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp Pro Gly 
        195                 200                 205             


Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys Arg Lys 
    210                 215                 220                 


Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys Thr Ala 
225                 230                 235                 240 


Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro Cys Ala 
                245                 250                 255     


Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile Cys Ala 
            260                 265                 270         


Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro Ile Cys 
        275                 280                 285             


Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys Asp Thr 
    290                 295                 300                 


Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn Pro Thr 
305                 310                 315                 320 


Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln Ser Leu 
                325                 330                 335     


Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr Ser Ala 
            340                 345                 350         


Pro Val Ala Leu Ser Ser Thr Gly Lys 
        355                 360     


<210>  164
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  Դ IgG ź

<400>  164

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  165
<211>  60
<212>  DNA
<213>  ˹

<220>
<223>  Դ IgG ź DNA 

<400>  165
atggagaccg acaccctgct gctctgggtc ctgctgctgt gggtgcccgg atccacagga     60


<210>  166
<211>  111
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  166

Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Phe Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  167
<211>  117
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  167

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Phe Val Phe Ser Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  168
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  168

Asp Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr His Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  169
<211>  143
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  169

Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser Val Ile Met 
1               5                   10                  15      


Ser Arg Met Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Thr Tyr Thr Ile His Trp Val Arg Gln Arg Pro Gly His Asp 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Asp Tyr 
65                  70                  75                  80  


Asn Gln Asn Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser 
                85                  90                  95      


Asn Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Arg Ala Asp Tyr Gly Asn Tyr Glu Tyr Thr 
        115                 120                 125             


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140             


