                         SEQUENCE LISTING

<110>  ݸ־Ƽ޹˾
 
<120>  űԭHRP-II

<130>  IP190435

<160>  38    

<170>  PatentIn version 3.3

<210>  1
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR-VH1


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be Tyr, Thr or Ser

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be Leu or Ile

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be Asp or Glu, preferably Asp

<400>  1

Gly Xaa Thr Xaa Thr Xaa Tyr Tyr Met Asn 
1               5                   10  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR-VH2


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be Leu, Val or Ile

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be Gln or Asn

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be Ala or Pro, preferably Ala

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be Gln or Asn

<400>  2

Asp Xaa Asn Pro Ile Xaa Gly Gly Thr Xaa Tyr Xaa Gln Lys Phe 
1               5                   10                  15  


<210>  3
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR-VH3


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be Lys or Arg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be Asp or Glu, preferably Asp

<400>  3

Thr Xaa Gly Ala Glu Xaa Tyr 
1               5           


<210>  4
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR-VL1


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be Leu or Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be Leu or Ile

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be Gln or Asn

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be Ile or Leu, preferably Leu

<400>  4

Ser Gln Ser Xaa Xaa Tyr Ser Xaa Gly Lys Ile Tyr Xaa Asn 
1               5                   10                  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR-VL2


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be Ile, Val or Leu

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be Ile or Leu, preferably Leu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be Asp or Glu

<400>  5

Gln Xaa Ser Lys Xaa Xaa Pro 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR-VL3


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be Ala or Gly

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be Ser, Tyr or Thr

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be Gln or Asn, preferably Gln

<400>  6

Leu Gln Xaa Thr Tyr Xaa Pro Xaa Thr 
1               5                   


<210>  7
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  SMARTER II A Oligonucleotide


<220>
<221>  misc_feature
<222>  (26)..(30)
<223>  n is a, c, g, or t

<400>  7
aagcagtggt atcaacgcag agtacnnnnn                                      30


<210>  8
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  5'RACE CDS Primer5'CDS)


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  v is a or g or c

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is a, c, g, or t

<400>  8
tttttttttt tttttttttt tttttvn                                         27


<210>  9
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Universal Primer A Mix(UPM)

<400>  9
ctaatacgac tcactatagg gcaagcagtg gtatcaacgc agagt                     45


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Nested Universal Primer A(NUP)

<400>  10
aagcagtggt atcaacgcag agt                                             23


<210>  11
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  mIgG CKR

<400>  11
cgcctaacac tcattcctgt tgaagc                                          26


<210>  12
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  mIgG CHR

<400>  12
ccgctcattt acccggagac cg                                              22


<210>  13
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Anti HRPII3R5HF

<400>  13
cccaagcttg ccaccatgta cttgggactg aactgtgtat tc                        42


<210>  14
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Anti HRPII3R5HR

<400>  14
ggggaattct cattactttc cgggagatct ggagatggtt tgcttg                    46


<210>  15
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Anti HRPII3R5LF

<400>  15
cccaagcttg ccaccatgga catcagggct cctgctcagt ttcttggc                  48


<210>  16
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Anti HRPII3R5LR

<400>  16
ggggaattct cattaacatt catttctgtt aaaagatttg acaatg                    46


<210>  17
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 1 Heavy Chain variable region

<400>  17

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Ser Thr Leu Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Leu Asn Pro Ile Asn Gly Gly Thr Ala Tyr Gln Gln Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ala Glu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  18
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 1 Heavy Chain

<400>  18

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Ser Thr Leu Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Leu Asn Pro Ile Asn Gly Gly Thr Ala Tyr Gln Gln Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ala Glu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
        115                 120                 125             


Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu 
145                 150                 155                 160 


Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr 
                165                 170                 175     


Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln 
            180                 185                 190         


Thr Val Thr Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp 
        195                 200                 205             


Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro 
    210                 215                 220                 


Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile 
                245                 250                 255     


Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
            260                 265                 270         


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
        275                 280                 285             


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg 
    290                 295                 300                 


Val Val Ser Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr 
            340                 345                 350         


Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp 
    370                 375                 380                 


Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys 
                405                 410                 415     


Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His 
            420                 425                 430         


Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro 
        435                 440                 445             


Gly 
    


<210>  19
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 1 Light Chain variable region

<400>  19

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Ile Tyr Ser 
            20                  25                  30          


Asn Gly Lys Ile Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Met Tyr Gln Leu Ser Lys Leu Asp Pro Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr Tyr Ser Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  20
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 1 Light Chain

<400>  20

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Ile Tyr Ser 
            20                  25                  30          


Asn Gly Lys Ile Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Met Tyr Gln Leu Ser Lys Leu Asp Pro Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr Tyr Ser Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  21
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 1 HEAVY CHAIN CDR1

<400>  21

Gly Ser Thr Leu Thr Asp Tyr Tyr Met Asn 
1               5                   10  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 1 HEAVY CHAIN CDR2

<400>  22

Asp Leu Asn Pro Ile Asn Gly Gly Thr Ala Tyr Gln Gln Lys Phe 
1               5                   10                  15  


<210>  23
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 1 HEAVY CHAIN CDR3

<400>  23

Thr Arg Gly Ala Glu Asp Tyr 
1               5           

<210>  24
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 1 LIGHT CHAIN CDR1

<400>  24

Ser Gln Ser Ile Ile Tyr Ser Asn Gly Lys Ile Tyr Leu Asn 
1               5                   10                  


<210>  25
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 1 LIGHT CHAIN CDR2 

<400>  25

Gln Leu Ser Lys Leu Asp Pro 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Variant 1 LIGHT CHAIN CDR3

<400>  26

Leu Gln Gly Thr Tyr Ser Pro Gln Thr 
1               5                   


<210>  27
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  FR-H1 

<400>  27

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  28
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  FR-H2

<400>  28

Trp Val Lys Gln Ser His Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  29
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  FR-H3 

<400>  29

Arg Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
1               5                   10                  15      


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
            20                  25                  30          


<210>  30
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  FR-H4

<400>  30

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  31
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  FR-L1

<400>  31

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser 
            20                  25  


<210>  32
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  FR-L2

<400>  32

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Met Tyr 
1               5                   10                  15  


<210>  33
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  FR-L3 

<400>  33

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  34
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  FR-L4

<400>  34

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  35
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  WT Heavy Chain variable region

<400>  35

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Ser Thr Leu Thr Glu Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Leu Asn Pro Ile Asn Gly Gly Thr Pro Tyr Gln Gln Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ala Glu Glu Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  36
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  WT Heavy Chain

<400>  36

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Ser Thr Leu Thr Glu Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Leu Asn Pro Ile Asn Gly Gly Thr Pro Tyr Gln Gln Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Ala Glu Glu Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
        115                 120                 125             


Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu 
145                 150                 155                 160 


Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr 
                165                 170                 175     


Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln 
            180                 185                 190         


Thr Val Thr Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp 
        195                 200                 205             


Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro 
    210                 215                 220                 


Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile 
                245                 250                 255     


Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
            260                 265                 270         


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
        275                 280                 285             


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg 
    290                 295                 300                 


Val Val Ser Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr 
            340                 345                 350         


Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp 
    370                 375                 380                 


Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys 
                405                 410                 415     


Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His 
            420                 425                 430         


Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro 
        435                 440                 445             


Gly 
    


<210>  37
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  WT Light Chain variable region

<400>  37

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Ile Tyr Ser 
            20                  25                  30          


Asn Gly Lys Ile Tyr Ile Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Met Tyr Gln Leu Ser Lys Ile Asp Pro Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr Tyr Ser Pro Asn Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  38
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  WT Light Chain

<400>  38

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Ile Tyr Ser 
            20                  25                  30          


Asn Gly Lys Ile Tyr Ile Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Met Tyr Gln Leu Ser Lys Ile Asp Pro Gly Ile Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr Tyr Ser Pro Asn Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 




