﻿                         序列表

<110>  黄欢

<120>  一种成骨发育不全疾病的致病突变及其检测试剂

<160>  5

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  4395
<212>  DNA
<213>  人类(Homo sapiens)

<400>  1
atgttcagct ttgtggacct ccggctcctg ctcctcttag cggccaccgc cctcctgacg        60
cacggccaag aggaaggcca agtcgagggc caagacgaag acatcccacc aatcacctgc       120
gtacagaacg gcctcaggta ccatgaccga gacgtgtgga aacccgagcc ctgccggatc       180
tgcgtctgcg acaacggcaa ggtgttgtgc gatgacgtga tctgtgacga gaccaagaac       240
tgccccggcg ccgaagtccc cgagggcgag tgctgtcccg tctgccccga cggctcagag       300
tcacccaccg accaagaaac caccggcgtc gagggaccca agggagacac tggcccccga       360
ggcccaaggg gacccgcagg cccccctggc cgagatggca tccctggaca gcctggactt       420
cccggacccc ccggaccccc cggacctccc ggaccccctg gcctcggagg aaactttgct       480
ccccagctgt cttatggcta tgatgagaaa tcaaccggag gaatttccgt gcctggcccc       540
atgggtccct ctggtcctcg tggtctccct ggcccccctg gtgcacctgg tccccaaggc       600
ttccaaggtc cccctggtga gcctggcgag cctggagctt caggtcccat gggtccccga       660
ggtcccccag gtccccctgg aaagaatgga gatgatgggg aagctggaaa acctggtcgt       720
cctggtgagc gtgggcctcc tgggcctcag ggtgctcgag gattgcccgg aacagctggc       780
ctccctggaa tgaagggaca cagaggtttc agtggtttgg atggtgccaa gggagatgct       840
ggtcctgctg gtcctaaggg tgagcctggc agccctggtg aaaatggagc tcctggtcag       900
atgggccccc gtggcctgcc tggtgagaga ggtcgccctg gagcccctgg ccctgctggt       960
gctcgtggaa atgatggtgc tactggtgct gccgggcccc ctggtcccac cggccccgct      1020
ggtcctcctg gcttccctgg tgctgttggt gctaagggtg aagctggtcc ccaagggccc      1080
cgaggctctg aaggtcccca gggtgtgcgt ggtgagcctg gcccccctgg ccctgctggt      1140
gctgctggcc ctgctggaaa ccctggtgct gatggacagc ctggtgctaa aggtgccaat      1200
ggtgctcctg gtattgctgg tgctcctggc ttccctggtg cccgaggccc ctctggaccc      1260
cagggccccg gcggccctcc tggtcccaag ggtaacagcg gtgaacctgg tgctcctggc      1320
agcaaaggag acactggtgc taagggagag cctggccctg ttggtgttca aggaccccct      1380
ggccctgctg gagaggaagg aaagcgagga gctcgaggtg aacccggacc cactggcctg      1440
cccggacccc ctggcgagcg tggtggacct ggtagccgtg gtttccctgg cgcagatggt      1500
gttgctggtc ccaagggtcc cgctggtgaa cgtggttctc ctggccctgc tggccccaaa      1560
ggatctcctg gtgaagctgg tcgtcccggt gaagctggtc tgcctggtgc caagggtctg      1620
actggaagcc ctggcagccc tggtcctgat ggcaaaactg gcccccctgg tcccgccggt      1680
caagatggtc gccccggacc cccaggccca cctggtgccc gtggtcaggc tggtgtgatg      1740
ggattccctg gacctaaagg tgctgctgga gagcccggca aggctggaga gcgaggtgtt      1800
cccggacccc ctggcgctgt cggtcctgct ggcaaagatg gagaggctgg agctcaggga      1860
ccccctggcc ctgctggtcc cgctggcgag agaggtgaac aaggccctgc tggctccccc      1920
ggattccagg gtctccctgg tcctgctggt cctccaggtg aagcaggcaa acctggtgaa      1980
cagggtgttc ctggagacct tggcgcccct ggcccctctg gagcaagagg cgagagaggt      2040
ttccctggcg agcgtggtgt gcaaggtccc cctggtcctg ctggtccccg aggggccaac      2100
ggtgctcccg gcaacgatgg tgctaagggt gatgctggtg cccctggagc tcccggtagc      2160
cagggcgccc ctggccttca gggaatgcct ggtgaacgtg gtgcagctgg tcttccaggg      2220
cctaagggtg acagaggtga tgctggtccc aaaggtgctg atggctctcc tggcaaagat      2280
ggcgtccgtg gtctgactgg ccccattggt cctcctggcc ctgctggtgc ccctggtgac      2340
aagggtgaaa gtggtcccag cggccctgct ggtcccactg gagctcgtgg tgcccccgga      2400
gaccgtggtg agcctggtcc ccccggccct gctggctttg ctggcccccc tggtgctgac      2460
ggccaacctg gtgctaaagg cgaacctggt gatgctggtg ctaaaggcga tgctggtccc      2520
cctggccctg ccggacccgc tggaccccct ggccccattg gtaatgttgg tgctcctgga      2580
gccaaaggtg ctcgcggcag cgctggtccc cctggtgcta ctggtttccc tggtgctgct      2640
ggccgagtcg gtcctcctgg cccctctgga aatgctggac cccctggccc tcctggtcct      2700
gctggcaaag aaggcggcaa aggtccccgt ggtgagactg gccctgctgg acgtcctggt      2760
gaagttggtc cccctggtcc ccctggccct gctggcgaga aaggatcccc tggtgctgat      2820
ggtcctgctg gtgctcctgg tactcccggg cctcaaggta ttgctggaca gcgtggtgtg      2880
gtcggcctgc ctggtcagag aggagagaga ggcttccctg gtcttcctgg cccctctggt      2940
gaacctggca aacaaggtcc ctctggagca agtggtgaac gtggtccccc tggtcccatg      3000
ggcccccctg gattggctgg accccctggt gaatctggac gtgagggggc tcctggtgcc      3060
gaaggttccc ctggacgaga cggttctcct ggcgccaagg gtgaccgtgg tgagaccggc      3120
cccgctggac cccctggtgc tcctggtgct cctggtgccc ctggccccgt tggccctgct      3180
ggcaagagtg gtgatcgtgg tgagactggt cctgctggtc ccgccggtcc tgtcggccct      3240
gttggcgccc gtggccccgc cggaccccaa ggcccccgtg gtgacaaggg tgagacaggc      3300
gaacagggcg acagaggcat aaagggtcac cgtggcttct ctggcctcca gggtccccct      3360
ggccctcctg gctctcctgg tgaacaaggt ccctctggag cctctggtcc tgctggtccc      3420
cgaggtcccc ctggctctgc tggtgctcct ggcaaagatg gactcaacgg tctccctggc      3480
cccattgggc cccctggtcc tcgcggtcgc actggtgatg ctggtcctgt tggtcccccc      3540
ggccctcctg gacctcctgg tccccctggt cctcccagcg ctggtttcga cttcagcttc      3600
ctgccccagc cacctcaaga gaaggctcac gatggtggcc gctactaccg ggctgatgat      3660
gccaatgtgg ttcgtgaccg tgacctcgag gtggacacca ccctcaagag cctgagccag      3720
cagatcgaga acatccggag cccagagggc agccgcaaga accccgcccg cacctgccgt      3780
gacctcaaga tgtgccactc tgactggaag agtggagagt actggattga ccccaaccaa      3840
ggctgcaacc tggatgccat caaagtcttc tgcaacatgg agactggtga gacctgcgtg      3900
taccccactc agcccagtgt ggcccagaag aactggtaca tcagcaagaa ccccaaggac      3960
aagaggcatg tctggttcgg cgagagcatg accgatggat tccagttcga gtatggcggc      4020
cagggctccg accctgccga tgtggccatc cagctgacct tcctgcgcct gatgtccacc      4080
gaggcctccc agaacatcac ctaccactgc aagaacagcg tggcctacat ggaccagcag      4140
actggcaacc tcaagaaggc cctgctcctc cagggctcca acgagatcga gatccgcgcc      4200
gagggcaaca gccgcttcac ctacagcgtc actgtcgatg gctgcacgag tcacaccgga      4260
gcctggggca agacagtgat tgaatacaaa accaccaaga cctcccgcct gcccatcatc      4320
gatgtggccc ccttggacgt tggtgcccca gaccaggaat tcggcttcga cgttggccct      4380
gtctgcttcc tgtaa                                                       4395

<210>  2
<211>  1464
<212>  PRT
<213>  人类(Homo sapiens)

<400>  2
Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      
Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          
Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              
Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  
Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  
Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      
Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         
Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             
Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 
Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 
Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     
Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         
Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             
Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 
Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 
Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     
Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         
Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             
Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 
Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 
Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     
Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         
Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             
Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 
Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 
Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     
Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         
Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             
Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 
Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 
Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     
Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         
Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             
Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 
Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 
Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     
Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         
Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             
Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 
Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 
Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     
Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         
Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             
Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 
Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 
Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     
Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         
Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             
Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 
Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 
Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     
Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         
Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             
Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 
Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 
Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     
Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         
Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             
Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 
Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 
Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     
Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         
Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             
Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser Pro 
    1010                 1015                 1020                 
Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu Thr Gly  
1025                 1030                 1035                 1040 
Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala Pro Gly  Pro 
                1045                 1050                 1055     
Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu Thr Gly  Pro Ala 
            1060                 1065                 1070         
Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala Arg Gly  Pro Ala Gly 
        1075                 1080                 1085             
Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu Thr Gly  Glu Gln Gly Asp 
    1090                 1095                 1100                 
Arg  Gly Ile Lys Gly His  Arg Gly Phe Ser Gly  Leu Gln Gly Pro Pro  
1105                 1110                 1115                 1120 
Gly Pro Pro Gly Ser  Pro Gly Glu Gln Gly  Pro Ser Gly Ala Ser  Gly 
                1125                 1130                 1135     
Pro Ala Gly Pro  Arg Gly Pro Pro Gly  Ser Ala Gly Ala Pro  Gly Lys 
            1140                 1145                 1150         
Asp Gly Leu  Asn Gly Leu Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg 
        1155                 1160                 1165             
Gly Arg  Thr Gly Asp Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly 
    1170                 1175                 1180                 
Pro  Pro Gly Pro Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  
1185                 1190                 1195                 1200 
Leu Pro Gln Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr 
                1205                 1210                 1215     
Arg Ala Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp 
            1220                 1225                 1230         
Thr Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
        1235                 1240                 1245             
Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys Met 
    1250                 1255                 1260                 
Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro Asn Gln  
1265                 1270                 1275                 1280 
Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met Glu Thr  Gly 
                1285                 1290                 1295     
Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala Gln Lys  Asn Trp 
            1300                 1305                 1310         
Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His Val Trp  Phe Gly Glu 
        1315                 1320                 1325             
Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr Gly Gly  Gln Gly Ser Asp 
    1330                 1335                 1340                 
Pro  Ala Asp Val Ala Ile  Gln Leu Thr Phe Leu  Arg Leu Met Ser Thr  
1345                 1350                 1355                 1360 
Glu Ala Ser Gln Asn  Ile Thr Tyr His Cys  Lys Asn Ser Val Ala  Tyr 
                1365                 1370                 1375     
Met Asp Gln Gln  Thr Gly Asn Leu Lys  Lys Ala Leu Leu Leu  Gln Gly 
            1380                 1385                 1390         
Ser Asn Glu  Ile Glu Ile Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr 
        1395                 1400                 1405             
Ser Val  Thr Val Asp Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys 
    1410                 1415                 1420                 
Thr  Val Ile Glu Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  
1425                 1430                 1435                 1440 
Asp Val Ala Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe 
                1445                 1450                 1455     
Asp Val Gly Pro  Val Cys Phe Leu 
            1460                 

<210>  3
<211>  18
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  3
tggcgctgtc gtaagtat                                                      18

<210>  4
<211>  18
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  4
cctgtaggtg ggaaatgg                                                      18

<210>  5
<211>  8733
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  5
tatagtgagt cgtattacaa ttcactggcc gtcgttttac aacgtcgtga ctgggaaaac        60
cctggcgtta cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat       120
agcgaagagg cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg       180
acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg       240
ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca       300
cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta       360
gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc       420
catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg       480
gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat       540
aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta       600
acgcgaattt taacaaaata ttaacgctta caatttcctg atgcggtatt ttctccttac       660
gcatctgtgc ggtatttcac accgcatcag gtggcacttt tcggggaaat gtgcgcggaa       720
cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac       780
cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg       840
tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc       900
tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg       960
atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga      1020
gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc      1080
aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag      1140
aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga      1200
gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg      1260
cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga      1320
atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt      1380
tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact      1440
ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt      1500
ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg      1560
ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta      1620
tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac      1680
tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat ttttaattta      1740
aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt      1800
tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt      1860
tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt      1920
gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc      1980
agataccaaa tactgttctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg      2040
tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg      2100
ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt      2160
cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac      2220
tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg      2280
acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg      2340
gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat      2400
ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt      2460
tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg      2520
attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa      2580
cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc      2640
ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga      2700
aagcgggcag tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg      2760
ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc      2820
acacaggaaa cagctatgac catgattacg ccaagctatt taggtgacac tatagaatac      2880
tcaagctatg catccaacgc gttgggagct ctcccatatg gtcgagcaga ggtgtaaaaa      2940
gtactcaaaa attttactca agtgaaagta caagtactta gggaaaattt tactcaatta      3000
aaagtaaaag tatctggcta gaatcttact tgagtaaaag taaaaaagta ctccattaaa      3060
attgtacttg agtattaagg aagtaaaagt aaaagcaaga aagaaaacta gagattcttg      3120
tttaagcgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt      3180
catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga      3240
ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca      3300
atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca      3360
gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg      3420
cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc      3480
tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt      3540
ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt      3600
ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg      3660
acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tctctggcta      3720
actagagaac ccactgctta ctggcttatc gaaattaata cgactcacta tagggagacc      3780
caagctggct agttaagctt gccaccatgt tcagctttgt ggatattcgg ctggcgctgt      3840
tgctcagcgc aacggtgctt ttggcaagag gacaaggcga ggacgatcgc actggcggca      3900
gctgcacatt ggacggccag gtctacaatg acagggacgt ctggaaacca gagccatgcc      3960
aaatctgcgt gtgcgacagc ggcaccgtaa tgtgcgacga agtgatctgc gaggacacaa      4020
gcgactgccc caacccagtg attccccacg acgagtgctg ccccgtctgc ccagacgacg      4080
atttccagga gcccagtgtt gagggaccta gaggttctcc cggtgacaag ggtgagaggg      4140
gtcctgctgg ccctcccggc aatgatggaa tccctggaca gcctggcctc cctgggcctc      4200
caggccctcc tggacctcct ggccttggtg gaaacttttc tcctcagatg tctggtggct      4260
ttgatgagaa atcctctcca atggctgtcc caggccccat gggacctatg ggcccccgtg      4320
gagcccctgg acctcctgga ccttccggac cccaaggatt tactggtccc cctggcgagc      4380
ctggtgaggc tggtgctcct ggtccaatgg gtccccgtgg cgctgctggt ccccctggaa      4440
agaatggaga ggatggtgag tctggcaaac ctggtcgccc tggtgagcgc ggaccccctg      4500
gaccacaggg tgctcgtgga ttccccggaa cccctggact tccaggcatc aagggacaca      4560
gaggattcag cggtctagat ggagctaagg gggatgctgg ccctgctgga cctaagggtg      4620
agcctggtgc acctggtgag aatggaactc ctggtgccat gggtccccgt ggtctgcctg      4680
gcgagagagg ccgtgctggt cctcctggtg ctgctggtgc tcgtggtaat gatggtgccg      4740
ctggagctgc tggtcctcct ggcccaactg gccctgctgg tcccccagga ttccctggcg      4800
gccctggatc taagggagag gttggtcctc agggatcccg tggtgcagag ggacctcagg      4860
gagcccgtgg tgaagctggt aaccctggac ctgctggtcc tgctggtccc gctggtaaca      4920
acggagctga tggtgcccct ggtgccaagg gtgctcctgg cgctcctggt attgctggtg      4980
ctcctggttt ccctggaccc cgtggtcctc ctggagctgc tggagcggct ggtgcccctg      5040
gccctaaggg taacaccggt gaggctggtg ccccaggtgc caaaggagag gctggtgcta      5100
agggagaggc tggtgcccaa ggagttcagg gtccccctgg tccccctggt gaggaaggca      5160
agagaggacc ccgtggtgag cccggtgctg gtggtgcccg cggacctact ggtgaacgtg      5220
gtgctcctgg tgctcgtggt ttccctggtg ctgatggagc tgcaggtcca agaggtgccc      5280
ctggtgagcg tggaggccct ggagttgttg gacctaaggg tgccactggt gagcctggcc      5340
gcaatggtga acctggtatg ccaggatcca agggtatgac tggtagccct ggcagccctg      5400
gacctgatgg aaagaccgga cctggtggtg ctcctggaca agatggccgc cctggaccac      5460
ctggccctgt tggagccaga ggacagcctg gtgtcatggg attccctgga cctaagggtg      5520
ctgctggtga ggctggcaaa cctggtgaga gaggagtgat gggtgctatt ggtgccacta      5580
gcgctcctgg taaggatggt gatgttggtg cccctggtgc tcctggacct gctggacctg      5640
ctggtgagag aggtgaacaa ggagctgctg gtcctcctgg attccagggt ctgccaggac      5700
ctcagggtgc tactggtgag ccaggaaagt ctggtgagca gggtgctcct ggagaagctg      5760
gagctcctgg accttctggt tctagaggtg acagaggatt ccctggtgag cgtggtgccc      5820
ctggccctgc tggccctgtt ggtgcccgtg gttctcctgg ttcagctggt aacgatggtg      5880
ccaagggtga aagtggtgcc gcaggtgctc ctggtgccca gggtcctcct ggacttcaag      5940
gaatgcctgg agagcgtggg gctgctggcc tccctggtct taagggtgac agaggtgacc      6000
aaggtgccaa gggtgctgat ggtgctgctg gtaaagatgg cattcgtggt atgaccggac      6060
caattggacc ccccggacct gctggagctc ctggtgacaa gggagaatct ggtgctcaag      6120
gacttgttgg acctactggt gcccgtggac cacctggtga gcgtggagag actggtgctc      6180
ctggacctgc cggatttgct ggacctcctg gtgctgatgg tctgcctggt gccaagggag      6240
aacctggaga taatggtgct aagggtgatg ctggtgctcc aggacctgca ggagcaactg      6300
gtgcccctgg acctcagggt cccgttggtg ctactggacc caagggtgcc cgtggtgctg      6360
ctggtcctcc tggtgctact ggcttccctg gtgctgctgg cagagttgga cctcctggcc      6420
cttctggaaa ttctggaccc ccaggacctc ctggacccgc tggtaaggag ggccagaaag      6480
gtaaccgtgg tgagactgga cctgctggtc gtactggtga agttggtgct gctggaccac      6540
ctggtgcccc tggtgagaaa ggaaatcccg gagctgaggg tgccactggc cctgctggta      6600
tccctggacc tcaaggtatt ggtggtcagc gtggtattgt aggtctccct ggacaaagag      6660
gcgagcgtgg tttccccggt ctccctggcc catctggaga gattggcaaa cagggacctt      6720
ctggtccatc tggtgaacgt ggacctcctg gccccatggg accccctgga ctggctggac      6780
ctcctggtga gcctggtcgt gagggtactc caggaaatga gggctctgct ggacgtgacg      6840
gtgctgctgg ccccaagggt gaccgtggtg agactggccc atctggcact cctggagccc      6900
ctggacctcc tggtgctgct ggacctattg gccctgctgg aaagactggt gatcgtggag      6960
agaccggccc tgctggtgtc cccggccctg ctggcccctc tggtccccgc ggaccctctg      7020
gacccgctgg agctcgtgga gacaagggtg agactggtga ggctggtgag agaggcatga      7080
agggacacag aggattcact ggaatgccag gaccccctgg tcctcctgga ccctctggag      7140
agtctggacc cgctggtgct tctggacccg ctggaccaag aggcccagct ggatctgctg      7200
gatcagctgg taaggatggt atgagtggcc tccctggacc cattggacct cctggacccc      7260
gtggtcgcaa tggagaaatt ggaccagctg gacctcctgg acctcccggc ccccctggag      7320
cacctggacc ctctggtggt ggattcgaca ttggcttcat tgcccagcca caggagaagg      7380
cccctgatcc cttccgtcac ttccgtgccg acgatgccaa tgtgatgcgc gaccgtgatc      7440
ttgaggttga caccaccctt aagtccctga gccagcagat tgagagcatc atcagcccag      7500
acggcaccaa gaagaaccct gcccgcactt gccgtgacct gaagatgtgc cacccagact      7560
ggaagagcgg cgagtactgg attgaccctg accagggctg caaccaggat gccatcaagg      7620
tctactgcaa catggaaact ggcgagactt gcgtcaaccc aactgagtct gctattccca      7680
agaagaactg gtacacaagc aagaacatta aggagaagaa acacgtctgg ttcggagagg      7740
ccatgaccga tggcttccag ttcgagtatg gcagcgaggg ctccaagcct gaggatgtca      7800
acattcagct caccttcctg cgcctcatgt ccactgaggc ctcccagaac attacatacc      7860
actgcaagaa cagcattgca tacatggacc aggcttctgg caacctgaag aaggctcttc      7920
tcctgcaggg ctccaacgaa attgagatca gagcagaggg caacagccgc ttcacataca      7980
gtgtcactga ggatggttgc acgtcgcaca ccggtgcatg gggcaagaca gtcattgact      8040
acaaaacaac gaaaacatcc cgtctgccta ttattgacat cgcccctatg gacgttggtg      8100
cacctaatca ggaatttggc attgaagttg gcccagtctg cttcttgtaa ggatccaccg      8160
gatctagata actgatcata atcagccata ccacatttgt agaggtttta cttgctttaa      8220
aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta      8280
acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa      8340
ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt      8400
aacgcgatcc atggaattca ctagtgcgcg cggccgctct agatggccag atctatttaa      8460
attaaactgg gcatcagcgc aattcaattg gtttggtaat agcaagggaa aatagaatga      8520
agtgatctcc aaaaaataag tactttttga ctgtaaataa aattgtaagg agtaaaaagt      8580
actttttttt ctaaaaaaat gtaattaagt aaaagtaaaa gtattgattt ttaattgtac      8640
tcaagtaaag taaaaatccc caaaaataat acttaagtac agtaatcaag taaaattact      8700
caagtacttt acacctctgg gcccaattcg ccc                                   8733

