                         SEQUENCE LISTING

<110>  Memorial Sloan-Kettering Cancer Center
       Research Foundation of the City University of New York
       The Johns Hopkins University
 
<120>  SALICYL-ADENOSINEMONOSULFAMATE ANALOGS AND USES THEREOF

<130>  S1715.70032WO00

<140>  PCT/US2019/068107
<141>  2019-12-20

<150>  US 62/784,323
<151>  2018-12-21

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Pro Pro Lys Ala Ala Asp Gly Arg Arg Pro Ser Pro Asp Gly Gly 
1               5                   10                  15      


Leu Gly Gly Phe Val Pro Phe Pro Ala Asp Arg Ala Ala Ser Tyr Arg 
            20                  25                  30          


Ala Ala Gly Tyr Trp Ser Gly Arg Thr Leu Asp Thr Val Leu Ser Asp 
        35                  40                  45              


Ala Ala Arg Arg Trp Pro Asp Arg Leu Ala Val Ala Asp Ala Gly Asp 
    50                  55                  60                  


Arg Pro Gly His Gly Gly Leu Ser Tyr Ala Glu Leu Asp Gln Arg Ala 
65                  70                  75                  80  


Asp Arg Ala Ala Ala Ala Leu His Gly Leu Gly Ile Thr Pro Gly Asp 
                85                  90                  95      


Arg Val Leu Leu Gln Leu Pro Asn Gly Cys Gln Phe Ala Val Ala Leu 
            100                 105                 110         


Phe Ala Leu Leu Arg Ala Gly Ala Ile Pro Val Met Cys Leu Pro Gly 
        115                 120                 125             


His Arg Ala Ala Glu Leu Gly His Phe Ala Ala Val Ser Ala Ala Thr 
    130                 135                 140                 


Gly Leu Val Val Ala Asp Val Ala Ser Gly Phe Asp Tyr Arg Pro Met 
145                 150                 155                 160 


Ala Arg Glu Leu Val Ala Asp His Pro Thr Leu Arg His Val Ile Val 
                165                 170                 175     


Asp Gly Asp Pro Gly Pro Phe Val Ser Trp Ala Gln Leu Cys Ala Gln 
            180                 185                 190         


Ala Gly Thr Gly Ser Pro Ala Pro Pro Ala Asp Pro Gly Ser Pro Ala 
        195                 200                 205             


Leu Leu Leu Val Ser Gly Gly Thr Thr Gly Met Pro Lys Leu Ile Pro 
    210                 215                 220                 


Arg Thr His Asp Asp Tyr Val Phe Asn Ala Thr Ala Ser Ala Ala Leu 
225                 230                 235                 240 


Cys Arg Leu Ser Ala Asp Asp Val Tyr Leu Val Val Leu Ala Ala Gly 
                245                 250                 255     


His Asn Phe Pro Leu Ala Cys Pro Gly Leu Leu Gly Ala Met Thr Val 
            260                 265                 270         


Gly Ala Thr Ala Val Phe Ala Pro Asp Pro Ser Pro Glu Ala Ala Phe 
        275                 280                 285             


Ala Ala Ile Glu Arg His Gly Val Thr Val Thr Ala Leu Val Pro Ala 
    290                 295                 300                 


Leu Ala Lys Leu Trp Ala Gln Ser Cys Glu Trp Glu Pro Val Thr Pro 
305                 310                 315                 320 


Lys Ser Leu Arg Leu Leu Gln Val Gly Gly Ser Lys Leu Glu Pro Glu 
                325                 330                 335     


Asp Ala Arg Arg Val Arg Thr Ala Leu Thr Pro Gly Leu Gln Gln Val 
            340                 345                 350         


Phe Gly Met Ala Glu Gly Leu Leu Asn Phe Thr Arg Ile Gly Asp Pro 
        355                 360                 365             


Pro Glu Val Val Glu His Thr Gln Gly Arg Pro Leu Cys Pro Ala Asp 
    370                 375                 380                 


Glu Leu Arg Ile Val Asn Ala Asp Gly Glu Pro Val Gly Pro Gly Glu 
385                 390                 395                 400 


Glu Gly Glu Leu Leu Val Arg Gly Pro Tyr Thr Leu Asn Gly Tyr Phe 
                405                 410                 415     


Ala Ala Glu Arg Asp Asn Glu Arg Cys Phe Asp Pro Asp Gly Phe Tyr 
            420                 425                 430         


Arg Ser Gly Asp Leu Val Arg Arg Arg Asp Asp Gly Asn Leu Val Val 
        435                 440                 445             


Thr Gly Arg Val Lys Asp Val Ile Cys Arg Ala Gly Glu Thr Ile Ala 
    450                 455                 460                 


Ala Ser Asp Leu Glu Glu Gln Leu Leu Ser His Pro Ala Ile Phe Ser 
465                 470                 475                 480 


Ala Ala Ala Val Gly Leu Pro Asp Gln Tyr Leu Gly Glu Lys Ile Cys 
                485                 490                 495     


Ala Ala Val Val Phe Ala Gly Ala Pro Ile Thr Leu Ala Glu Leu Asn 
            500                 505                 510         


Gly Tyr Leu Asp Arg Arg Gly Val Ala Ala His Thr Arg Pro Asp Gln 
        515                 520                 525             


Leu Val Ala Met Pro Ala Leu Pro Thr Thr Pro Ile Gly Lys Ile Asp 
    530                 535                 540                 


Lys Arg Ala Ile Val Arg Gln Leu Gly Ile Ala Thr Gly Pro Val Thr 
545                 550                 555                 560 


Thr Gln Arg Cys His 
                565 


<210>  2
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Ser Thr Leu Ala Asn Leu Thr Glu Val Leu Phe Arg Leu Asp Phe 
1               5                   10                  15      


Asp Pro Asp Thr Ala Val Tyr His Tyr Arg Gly Gln Thr Leu Ser Arg 
            20                  25                  30          


Leu Gln Cys Arg Thr Tyr Ile Leu Ser Gln Ala Ser Gln Leu Ala Arg 
        35                  40                  45              


Leu Leu Lys Pro Gly Asp Arg Val Val Leu Ala Leu Asn Asp Ser Pro 
    50                  55                  60                  


Ser Leu Ala Cys Leu Phe Leu Ala Cys Ile Ala Val Gly Ala Ile Pro 
65                  70                  75                  80  


Ala Val Ile Asn Pro Lys Ser Arg Glu Gln Ala Leu Ala Asp Ile Ala 
                85                  90                  95      


Ala Asp Cys Gln Ala Ser Leu Val Val Arg Glu Ala Asp Ala Pro Ser 
            100                 105                 110         


Leu Ser Gly Pro Leu Ala Pro Leu Thr Leu Arg Ala Ala Ala Gly Arg 
        115                 120                 125             


Pro Leu Leu Asp Asp Phe Ser Leu Asp Ala Leu Val Gly Pro Ala Asp 
    130                 135                 140                 


Leu Asp Trp Ser Ala Phe His Arg Gln Asp Pro Ala Ala Ala Cys Phe 
145                 150                 155                 160 


Leu Gln Tyr Thr Ser Gly Ser Thr Gly Ala Pro Lys Gly Val Met His 
                165                 170                 175     


Ser Leu Arg Asn Thr Leu Gly Phe Cys Arg Ala Phe Ala Thr Glu Leu 
            180                 185                 190         


Leu Ala Leu Gln Ala Gly Asp Arg Leu Tyr Ser Ile Pro Lys Met Phe 
        195                 200                 205             


Phe Gly Tyr Gly Met Gly Asn Ser Leu Phe Phe Pro Trp Phe Ser Gly 
    210                 215                 220                 


Ala Ser Ala Leu Leu Asp Asp Thr Trp Pro Ser Pro Glu Arg Val Leu 
225                 230                 235                 240 


Glu Asn Leu Val Ala Phe Arg Pro Arg Val Leu Phe Gly Val Pro Ala 
                245                 250                 255     


Ile Tyr Ala Ser Leu Arg Pro Gln Ala Arg Glu Leu Leu Ser Ser Val 
            260                 265                 270         


Arg Leu Ala Phe Ser Ala Gly Ser Pro Leu Pro Arg Gly Glu Phe Glu 
        275                 280                 285             


Phe Trp Ala Ala His Gly Leu Glu Ile Cys Asp Gly Ile Gly Ala Thr 
    290                 295                 300                 


Glu Val Gly His Val Phe Leu Ala Asn Arg Pro Gly Gln Ala Arg Ala 
305                 310                 315                 320 


Asp Ser Thr Gly Leu Pro Leu Pro Gly Tyr Glu Cys Arg Leu Val Asp 
                325                 330                 335     


Arg Glu Gly His Thr Ile Glu Glu Ala Gly Arg Gln Gly Val Leu Leu 
            340                 345                 350         


Val Arg Gly Pro Gly Leu Ser Pro Gly Tyr Trp Arg Ala Ser Glu Glu 
        355                 360                 365             


Gln Gln Ala Arg Phe Ala Gly Gly Trp Tyr Arg Thr Gly Asp Leu Phe 
    370                 375                 380                 


Glu Arg Asp Glu Ser Gly Ala Tyr Arg His Cys Gly Arg Glu Asp Asp 
385                 390                 395                 400 


Leu Phe Lys Val Asn Gly Arg Trp Val Val Pro Thr Gln Val Glu Gln 
                405                 410                 415     


Ala Ile Cys Arg His Leu Pro Glu Val Ser Glu Ala Val Leu Val Pro 
            420                 425                 430         


Thr Cys Arg Leu His Asp Gly Leu Arg Pro Thr Leu Phe Val Thr Leu 
        435                 440                 445             


Ala Thr Pro Leu Asp Asp Asn Gln Ile Leu Leu Ala Gln Arg Ile Asp 
    450                 455                 460                 


Gln His Leu Ala Glu Gln Ile Pro Ser His Met Leu Pro Ser Gln Leu 
465                 470                 475                 480 


His Val Leu Pro Ala Leu Pro Arg Asn Asp Asn Gly Lys Leu Ala Arg 
                485                 490                 495     


Ala Glu Leu Arg His Leu Ala Asp Thr Leu Tyr His Asp Asn Leu Pro 
            500                 505                 510         


Glu Glu Arg Ala Cys 
        515         


<210>  3
<211>  1770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
atgggcagca gccatcatca tcatcatcat catcatcatc acagcagcgg cctggtgccg       60

cgcggcagcc atatgccgcc gaaagcggcg gatggtcgtc gtccgagccc ggatggtggt      120

ctgggtggtt ttgtgccgtt cccggcggat cgtgcggcga gctaccgtgc ggcgggttat      180

tggagcggcc gtaccctgga caccgtgctg agcgatgcgg cgcgtcgttg gccggatcgt      240

ctggcggttg cggatgcggg tgatcgtccg ggccacggtg gcctgagcta cgcggaactg      300

gaccagcgtg cggatcgtgc tgcggcggcg ctgcacggtc tgggtatcac cccgggcgat      360

cgtgtgctgc tgcagctgcc gaacggttgc caattcgcgg ttgcgctgtt tgcgctgctg      420

cgtgcgggtg cgattccggt gatgtgcctg ccgggtcatc gtgcggcgga actgggtcac      480

tttgcggcgg tgagcgcggc gaccggcctg gtggttgcgg atgttgcgag cggttttgat      540

tatcgtccga tggcgcgtga gctggttgcg gaccacccga ccctgcgtca cgtgatcgtt      600

gacggtgatc cgggtccgtt tgttagctgg gcgcagctgt gcgcgcaagc gggcaccggc      660

agcccggctc cgccggcgga cccgggcagc ccggcgctgc tgctggttag cggtggcacc      720

accggtatgc cgaagctgat tccgcgtacc cacgacgatt atgtgtttaa cgcgaccgcg      780

agcgcggcgc tgtgccgtct gagcgcggac gatgtttatc tggtggttct ggcggcgggt      840

cacaactttc cgctggcgtg cccgggtctg ctgggtgcga tgaccgtggg tgcgaccgcg      900

gtttttgcgc cggacccgag cccggaggcg gcgtttgcgg cgattgaacg tcacggtgtt      960

accgttaccg cgctggtgcc ggcgctggcg aaactgtggg cgcagagctg cgagtgggaa     1020

ccggtgaccc cgaagagcct gcgtctgctg caagttggtg gcagcaaact ggagccggaa     1080

gatgcgcgtc gtgtgcgtac cgcgctgacc ccgggcctgc agcaagtttt cggtatggcg     1140

gaaggcctgc tgaactttac ccgtatcggt gacccgccgg aagtggttga acacacccaa     1200

ggtcgtccgc tgtgcccggc ggacgagctg cgtattgtga acgcggatgg tgaaccggtt     1260

ggtccgggcg aggaaggtga actgctggtg cgtggcccgt acaccctgaa cggttatttc     1320

gcggcggagc gtgacaacga acgttgcttc gacccggatg gtttttaccg tagcggcgat     1380

ctggttcgtc gtcgtgacga tggcaacctg gtggttaccg gtcgtgtgaa ggacgttatc     1440

tgccgtgcgg gtgaaaccat tgcggcgagc gatctggagg aacagctgct gagccatccg     1500

gcgattttca gcgctgcggc ggttggcctg ccggaccaat acctgggtga aaaaatctgc     1560

gcggcggtgg tttttgcggg tgcgccgatt accctggcgg agctgaacgg ctatctggac     1620

cgtcgtggtg tggcggcgca cacccgtccg gatcaactgg ttgcgatgcc ggcgctgccg     1680

accaccccga tcggcaagat tgataaacgt gcgattgttc gtcaactggg tattgcgacc     1740

ggcccggtta ccacccaacg ctgccactaa                                      1770


<210>  4
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Gly Ser Ser His His His His His His His His His His Ser Ser 
1               5                   10                  15      


Gly Leu Val Pro Arg Gly Ser His Met Pro Pro Lys Ala Ala Asp Gly 
            20                  25                  30          


Arg Arg Pro Ser Pro Asp Gly Gly Leu Gly Gly Phe Val Pro Phe Pro 
        35                  40                  45              


Ala Asp Arg Ala Ala Ser Tyr Arg Ala Ala Gly Tyr Trp Ser Gly Arg 
    50                  55                  60                  


Thr Leu Asp Thr Val Leu Ser Asp Ala Ala Arg Arg Trp Pro Asp Arg 
65                  70                  75                  80  


Leu Ala Val Ala Asp Ala Gly Asp Arg Pro Gly His Gly Gly Leu Ser 
                85                  90                  95      


Tyr Ala Glu Leu Asp Gln Arg Ala Asp Arg Ala Ala Ala Ala Leu His 
            100                 105                 110         


Gly Leu Gly Ile Thr Pro Gly Asp Arg Val Leu Leu Gln Leu Pro Asn 
        115                 120                 125             


Gly Cys Gln Phe Ala Val Ala Leu Phe Ala Leu Leu Arg Ala Gly Ala 
    130                 135                 140                 


Ile Pro Val Met Cys Leu Pro Gly His Arg Ala Ala Glu Leu Gly His 
145                 150                 155                 160 


Phe Ala Ala Val Ser Ala Ala Thr Gly Leu Val Val Ala Asp Val Ala 
                165                 170                 175     


Ser Gly Phe Asp Tyr Arg Pro Met Ala Arg Glu Leu Val Ala Asp His 
            180                 185                 190         


Pro Thr Leu Arg His Val Ile Val Asp Gly Asp Pro Gly Pro Phe Val 
        195                 200                 205             


Ser Trp Ala Gln Leu Cys Ala Gln Ala Gly Thr Gly Ser Pro Ala Pro 
    210                 215                 220                 


Pro Ala Asp Pro Gly Ser Pro Ala Leu Leu Leu Val Ser Gly Gly Thr 
225                 230                 235                 240 


Thr Gly Met Pro Lys Leu Ile Pro Arg Thr His Asp Asp Tyr Val Phe 
                245                 250                 255     


Asn Ala Thr Ala Ser Ala Ala Leu Cys Arg Leu Ser Ala Asp Asp Val 
            260                 265                 270         


Tyr Leu Val Val Leu Ala Ala Gly His Asn Phe Pro Leu Ala Cys Pro 
        275                 280                 285             


Gly Leu Leu Gly Ala Met Thr Val Gly Ala Thr Ala Val Phe Ala Pro 
    290                 295                 300                 


Asp Pro Ser Pro Glu Ala Ala Phe Ala Ala Ile Glu Arg His Gly Val 
305                 310                 315                 320 


Thr Val Thr Ala Leu Val Pro Ala Leu Ala Lys Leu Trp Ala Gln Ser 
                325                 330                 335     


Cys Glu Trp Glu Pro Val Thr Pro Lys Ser Leu Arg Leu Leu Gln Val 
            340                 345                 350         


Gly Gly Ser Lys Leu Glu Pro Glu Asp Ala Arg Arg Val Arg Thr Ala 
        355                 360                 365             


Leu Thr Pro Gly Leu Gln Gln Val Phe Gly Met Ala Glu Gly Leu Leu 
    370                 375                 380                 


Asn Phe Thr Arg Ile Gly Asp Pro Pro Glu Val Val Glu His Thr Gln 
385                 390                 395                 400 


Gly Arg Pro Leu Cys Pro Ala Asp Glu Leu Arg Ile Val Asn Ala Asp 
                405                 410                 415     


Gly Glu Pro Val Gly Pro Gly Glu Glu Gly Glu Leu Leu Val Arg Gly 
            420                 425                 430         


Pro Tyr Thr Leu Asn Gly Tyr Phe Ala Ala Glu Arg Asp Asn Glu Arg 
        435                 440                 445             


Cys Phe Asp Pro Asp Gly Phe Tyr Arg Ser Gly Asp Leu Val Arg Arg 
    450                 455                 460                 


Arg Asp Asp Gly Asn Leu Val Val Thr Gly Arg Val Lys Asp Val Ile 
465                 470                 475                 480 


Cys Arg Ala Gly Glu Thr Ile Ala Ala Ser Asp Leu Glu Glu Gln Leu 
                485                 490                 495     


Leu Ser His Pro Ala Ile Phe Ser Ala Ala Ala Val Gly Leu Pro Asp 
            500                 505                 510         


Gln Tyr Leu Gly Glu Lys Ile Cys Ala Ala Val Val Phe Ala Gly Ala 
        515                 520                 525             


Pro Ile Thr Leu Ala Glu Leu Asn Gly Tyr Leu Asp Arg Arg Gly Val 
    530                 535                 540                 


Ala Ala His Thr Arg Pro Asp Gln Leu Val Ala Met Pro Ala Leu Pro 
545                 550                 555                 560 


Thr Thr Pro Ile Gly Lys Ile Asp Lys Arg Ala Ile Val Arg Gln Leu 
                565                 570                 575     


Gly Ile Ala Thr Gly Pro Val Thr Thr Gln Arg Cys His 
            580                 585                 


<210>  5
<211>  7523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Thr Ala Asp Ser Leu Asp Ile Ala Glu Leu Leu Glu Leu Trp Asn 
1               5                   10                  15      


Asn His Ser Thr Pro Glu Arg Thr Ser Thr Val Pro Thr Leu Phe Ala 
            20                  25                  30          


Ala Gln Cys Ala Leu Thr Pro Asp Glu Val Ala Val Val Asp Gly Glu 
        35                  40                  45              


Arg Arg Leu Thr Tyr Arg His Leu Glu Thr His Val Ala Gln Leu Ala 
    50                  55                  60                  


His Ala Val Arg Val Ala Ala Gly Glu Gly Pro Glu Pro Ile Val Ala 
65                  70                  75                  80  


Ile Gly Val Pro Arg Ser Ala Glu Met Val Val Cys Val Leu Ala Ala 
                85                  90                  95      


Met Met Ala Gly Val Ala Phe Val Pro Leu Asp Pro Ser Trp Pro Ala 
            100                 105                 110         


His Arg Arg Arg Gln Val Leu Ala Asp Ser Gly Ala Val Ala Thr Phe 
        115                 120                 125             


Ile Thr Arg Glu Asp Glu Ser Asp Trp Gly Val Pro Gly Leu Arg Val 
    130                 135                 140                 


Asp Leu Gly Ala Trp Gln Phe Thr Ala Glu Ser Pro Val Leu Pro Gln 
145                 150                 155                 160 


Ala Asp Val His Pro Ala Gln Leu Ala Tyr Val Ile Phe Thr Ser Gly 
                165                 170                 175     


Ser Thr Gly Lys Pro Lys Gly Ala Met Ile Arg His Asp Ala Ile Ala 
            180                 185                 190         


Glu Arg Leu Gln Trp Gln Arg Asp His Ile Leu His Phe Gly Lys His 
        195                 200                 205             


Asp His Thr Asp Ala Ser Leu Phe Lys Ala Pro Leu Ser Phe Asp Ile 
    210                 215                 220                 


Ser Val Asn Glu Ile Leu Leu Pro Leu Val Ser Gly Gly Arg Val Val 
225                 230                 235                 240 


Val Ala Val Pro Asp Gly Glu Lys Asp Pro Glu Tyr Leu Leu Glu Leu 
                245                 250                 255     


Ile Arg Thr Glu Gln Val Thr Phe Val Tyr Leu Val Ser Ser Met Leu 
            260                 265                 270         


Asp Thr Leu Leu Glu Leu Asp Arg Leu Ala Thr Ala Asp Gly Ala Pro 
        275                 280                 285             


Ser Ser Leu Ala Ser Leu Arg His Val Trp Cys Gly Gly Glu Val Leu 
    290                 295                 300                 


Thr Pro Gly Leu Phe Ala Arg Phe Arg Lys Gln Leu Thr Thr Thr Leu 
305                 310                 315                 320 


Tyr His Gly Tyr Gly Pro Ala Glu Ala Thr Ile Gly Val Ser His Val 
                325                 330                 335     


Ile Tyr Arg Asp Thr Ala Glu Arg Ile Ala Thr Ser Ile Gly Arg Pro 
            340                 345                 350         


Asn Pro His Thr Gln Leu Tyr Val Leu Asp Glu Tyr Leu Arg Pro Val 
        355                 360                 365             


Pro Pro Gly Val Gly Gly Glu Leu Tyr Ala Ala Gly Phe Leu Leu Gly 
    370                 375                 380                 


Arg Gly Tyr Val Asn Ala Pro Ser Leu Thr Ala Ser Arg Phe Val Ala 
385                 390                 395                 400 


Asn Pro Phe Asp Gly Asn Gly Ser Arg Met Tyr Arg Thr Gly Asp Leu 
                405                 410                 415     


Ala Arg Trp Thr Glu Asp Gly Ser Leu Glu Phe Leu Gly Arg Ala Asp 
            420                 425                 430         


Asn Gln Val Lys Ile Gly Gly Arg Arg Val Glu Leu Glu Glu Ile Glu 
        435                 440                 445             


Ser Gln Leu Ala Asp His Pro Ala Val Arg His Ala Val Val Asp Val 
    450                 455                 460                 


His Arg Gln Gly Gly Ala Asp Val Leu Val Gly Tyr Leu Val Ala Ala 
465                 470                 475                 480 


Asp Gly Val Arg Asn Asp Ala Ala Trp His Ala Glu Val Ala Asp Trp 
                485                 490                 495     


Ala Arg Thr Arg Leu Pro Glu Tyr Met Val Pro Lys Ala Phe Val Ala 
            500                 505                 510         


Leu Asp Gln Val Pro Leu Thr Ala Asn Gly Lys Thr Asp Arg Arg Ala 
        515                 520                 525             


Leu Pro Ala Pro Asp Leu Glu Arg Ser Gly Thr Val Lys Pro Pro Arg 
    530                 535                 540                 


Thr Pro Arg Glu Thr Val Leu Cys Gln Val Phe Ala Asp Ala Leu Asp 
545                 550                 555                 560 


Ile Asp Ala Val Gly Val Asp Glu Asp Phe Phe Ala Leu Gly Gly Asp 
                565                 570                 575     


Ser Ile Val Ala Ile Arg Val Val Ser Arg Leu Arg Ala Ala Gly Tyr 
            580                 585                 590         


Thr Leu Arg Pro Arg Asp Met Phe Ala His Arg Thr Val Glu Ala Leu 
        595                 600                 605             


Ala Pro Leu Leu Gly Asp Ser Asp Val Arg Asp Thr Gly Pro Ala Val 
    610                 615                 620                 


Asp Pro Thr Gly Ala Ala Thr Pro Thr Pro Ile Leu Arg Trp Leu Asp 
625                 630                 635                 640 


Glu Val Gly Thr Ala Gly Ser Val Leu Asn Gly Phe His Gln Gly Met 
                645                 650                 655     


Ser Leu Val Thr Pro Ala Asp Ala Asp Glu Asn Thr Leu Arg Ala Ala 
            660                 665                 670         


Ile Ala Ala Thr Val Arg Arg His His Val Leu Trp Ala Pro Pro Gly 
        675                 680                 685             


Arg Thr Ala Ser Asp Ile Asp Ile Pro Gly Thr Pro Pro Glu Thr Arg 
    690                 695                 700                 


Leu Leu Ile Ala Asp Ala Ser Asp Gly Ile Pro Ala Gln Ala Glu Lys 
705                 710                 715                 720 


Val Ala Arg Gln Leu Val Ser Leu Leu Asp Thr Ala Arg Ile Ala Phe 
                725                 730                 735     


Gly Trp Ile Arg Arg Pro Ala Ala Pro Gly Arg Leu Val Val Ile Ala 
            740                 745                 750         


Asp His Thr Val Ile Asp Gly Val Ser Leu Arg Ile Leu Ala Glu Asp 
        755                 760                 765             


Ile Ala Thr Ala Tyr Gly Leu Ile Ala Glu Gly Arg Ala Val Glu Leu 
    770                 775                 780                 


Pro Thr Pro His Thr Ser Trp Arg Ala Trp Ala Gln Arg Leu Ala Asp 
785                 790                 795                 800 


Thr Ala Ala Ala Gly Gly Phe Asp Ala Asp Leu Glu His Trp Gln Gln 
                805                 810                 815     


Val Cys Ala Thr Thr Glu Thr Pro Trp Gly Asp Arg Ala Leu Asp Pro 
            820                 825                 830         


Ala Ile Asp Thr Val Ala Thr Glu Ser Arg Leu Thr Val Glu Leu Pro 
        835                 840                 845             


Ser Ala Val Thr Asp Ala Ile Leu Thr Thr Val Pro Asp Arg Ile His 
    850                 855                 860                 


Gly His Val Asn Asp Ala Leu Val Ala Ala Leu Tyr Leu Ala Leu Arg 
865                 870                 875                 880 


Arg Trp Leu His Thr Arg Gly Val Gly Ala Asp Thr Leu Leu Val Glu 
                885                 890                 895     


Met Glu Gly His Gly Arg Glu Gly His Leu Val Asp Ser Asp Thr Ala 
            900                 905                 910         


Gly Leu Asp Leu Ser Asn Thr Val Gly Trp Phe Thr Thr Leu Tyr Pro 
        915                 920                 925             


Val Ala Leu Arg Asp Ala Glu Phe Asp Trp Gln Ala Ala Val Ser Gly 
    930                 935                 940                 


Gly Pro Gln Leu Gly Ala Ala Val Arg Ser Val Lys Asp Gln Leu Arg 
945                 950                 955                 960 


Ser Val Pro Ser His Gly Phe Ser Tyr Gly Ala Leu Arg Tyr Leu Arg 
                965                 970                 975     


Asp Gly Thr Ser Gly Leu Glu Ala Ala Pro Gln Val Leu Phe Asn Tyr 
            980                 985                 990         


Leu Gly Arg Phe Gly Thr Ala Asp  Arg Pro Trp Ala Leu  Ala Asn Asp 
        995                 1000                 1005             


Thr Thr  Ala Val Leu Glu Asp  Arg Asp Pro Gly Met  Pro Leu Pro 
    1010                 1015                 1020             


Arg Leu  Leu Glu Val Asn Ala  Glu Ala Val Thr Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ser Val  Leu Arg Ala Thr Phe  Ser Trp Pro Ala His  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Asp Val Arg Thr Leu  Ala Gly Met Trp Thr  Asp Leu Leu 
    1055                 1060                 1065             


Thr Ala  Ile Ala Ser Ser Asp  Asp Val Arg Gly His  Ser Ala Ser 
    1070                 1075                 1080             


Asp Phe  Asp Arg Val Ser Val  Thr Ala Asp Asp Val  Ala Glu Leu 
    1085                 1090                 1095             


Glu Arg  Arg Tyr Pro Gly Leu  Thr Asp Leu Leu Pro  Leu Thr Pro 
    1100                 1105                 1110             


Thr Gln  Gln Gly Ile Tyr Phe  His Ser Thr Phe Ser  Arg Asp Arg 
    1115                 1120                 1125             


Asp Pro  Tyr Val Val Gln Gln  Ile Val Asp Ile Thr  Gly Pro Leu 
    1130                 1135                 1140             


Asp Thr  Glu Arg Phe Gln Arg  Ala Thr Glu Ser Val  Ala Ala Arg 
    1145                 1150                 1155             


His Arg  Ala Leu Gly Ala Val  Phe Thr Thr Leu Ser  Asp Gly Thr 
    1160                 1165                 1170             


Pro Val  Ala Val His Ala Ala  Thr Val Ala Pro Asp  Phe Asp Val 
    1175                 1180                 1185             


Leu Asp  Ala Arg His Ala Ala  Asp Pro Ser Thr Val  Val Ala Gln 
    1190                 1195                 1200             


Arg Ala  Arg Trp Glu Arg Glu  Arg Arg Phe Asp Leu  Ala Ala Ala 
    1205                 1210                 1215             


Pro Leu  Thr Arg Tyr Thr Leu  Val Arg Arg Arg Asp  Asp Leu His 
    1220                 1225                 1230             


Thr Met  Ile Glu Thr Val His  His Ile Val Ala Asp  Gly Trp Ser 
    1235                 1240                 1245             


Val Pro  Ile Val Leu Asp Asp  Leu Leu Thr Ala Tyr  Ala Gly Asp 
    1250                 1255                 1260             


Asp Phe  Asp Gly Pro Ala Pro  Glu Phe Ala Arg Phe  Val Asp Trp 
    1265                 1270                 1275             


Leu Glu  Gln Arg Asp Thr Asp  Ser Asp Arg Ala Ala  Trp Ala Pro 
    1280                 1285                 1290             


Ala Leu  Glu Asp Ile Thr Glu  Pro Thr Arg Leu Ala  Ala Ala Asp 
    1295                 1300                 1305             


Gly Ala  Arg Gly Arg Thr Thr  Gly Ser Gly Phe Gly  Thr Arg Thr 
    1310                 1315                 1320             


Val Thr  Leu Gln Ser Arg Ser  Ala Val Ala Asp Ala  Ala Asn Gly 
    1325                 1330                 1335             


Ala Ala  Val Thr Val Gly Thr  Leu Leu His Thr Ala  Trp Gly Leu 
    1340                 1345                 1350             


Ala Leu  Gly Arg Leu Thr Gly  Arg Asp Asp Val Val  Phe Gly Thr 
    1355                 1360                 1365             


Val Val  Ser Gly Arg Gly Ala  Asp Val His Gly Ile  Glu Ser Met 
    1370                 1375                 1380             


Val Gly  Leu Leu Val Asn Thr  Val Pro Val Arg Val  Ala Trp Ser 
    1385                 1390                 1395             


Ala Asp  Asp Thr Gly Ala Asp  Val Ala Gly Arg Leu  Ala Ala Val 
    1400                 1405                 1410             


Glu Ser  Thr Leu Leu Glu His  His His Leu Pro Leu  Thr Glu Ala 
    1415                 1420                 1425             


His Arg  Leu Ala Gly Val Gly  Glu Leu Phe Asp Thr  Leu Val Val 
    1430                 1435                 1440             


Ile Glu  Asn Leu Gly Ala Thr  Thr His Thr Arg Gly  Asp Leu Thr 
    1445                 1450                 1455             


Leu Gly  Asp Ile Gly Val Ile  Glu Ala Pro His Tyr  Pro Leu Thr 
    1460                 1465                 1470             


Leu Met  Ile Ser Val Arg Asp  Thr Ile Thr Val Thr  Val Thr Asn 
    1475                 1480                 1485             


Asp Arg  Glu His Val Ser Asp  Val Leu Ala Asp Thr  Ala Val Ala 
    1490                 1495                 1500             


Ala Phe  Thr Glu Val Leu Thr  Ala Leu Thr Ala Asp  Pro Gly Val 
    1505                 1510                 1515             


Ser Pro  Gly Asp Ile Ala Leu  Pro Ala Pro Gln Ala  Thr Ala Pro 
    1520                 1525                 1530             


Pro Thr  Gln Ala Pro Gln Thr  Val Thr Asp Leu Ile  Ala Ala Ala 
    1535                 1540                 1545             


Ile Ala  Glu His Arg Asp Asp  Ile Ala Leu Val Val  Gly Glu Thr 
    1550                 1555                 1560             


Glu Trp  Thr Tyr Gly Gln Leu  Gly Ala Arg Ala Gly  Glu Leu Ala 
    1565                 1570                 1575             


Ala Ala  Leu Ala Glu Ala Gly  Val Arg Arg Gly Asp  Ile Val Ala 
    1580                 1585                 1590             


Leu Ala  Thr Ala Arg Ser Ala  Asp Leu Val Ala Ala  Ile Trp Ala 
    1595                 1600                 1605             


Ile Ile  Ala Ala Gly Ala Ala  Tyr Leu Pro Val Asp  Leu Ala Tyr 
    1610                 1615                 1620             


Pro Arg  Thr Arg Ile Glu Tyr  Met Leu Arg His Ala  Arg Pro Thr 
    1625                 1630                 1635             


Ala Val  Ile Ala Asp Gly Val  Gly Ala His Val Val  Ser Gly Ala 
    1640                 1645                 1650             


Leu Pro  Ala Asp Thr Ile Val  Val Ser Thr Thr Ala  Thr His Ala 
    1655                 1660                 1665             


Ala Val  Pro Phe Thr Pro Val  Pro Val Asp Gly Ala  Asp Ala Val 
    1670                 1675                 1680             


Ser Val  Leu Tyr Thr Ser Gly  Ser Thr Gly Glu Pro  Lys Ala Val 
    1685                 1690                 1695             


Val Gly  Thr His Ala Ala Leu  Ala Asn Arg Leu Ala  Trp Ala Val 
    1700                 1705                 1710             


Glu Ala  Trp Pro Ala Ala Thr  Arg Ile Ala Lys Ser  Pro Leu Ser 
    1715                 1720                 1725             


Phe Ile  Asp Gly Thr Thr Glu  Leu Leu Ala Gly Leu  Ala Ala Gly 
    1730                 1735                 1740             


Ala Arg  Thr Val Leu Ala Gly  Asp Glu Thr Ala Arg  Asp Gly Arg 
    1745                 1750                 1755             


Arg Leu  Ala Gln Leu Val Ala  Ala His Gly Val Glu  Gln Leu Leu 
    1760                 1765                 1770             


Ala Val  Pro Ser Leu Ala Ala  Val Leu Ala Asp Glu  Arg Thr Glu 
    1775                 1780                 1785             


Asp Val  Ala Glu Leu Asn Arg  Trp Ile Val Ser Gly  Glu Ala Leu 
    1790                 1795                 1800             


Glu Pro  Arg His Leu His Ala  Leu Arg Thr Ala Cys  Pro Thr Ala 
    1805                 1810                 1815             


Glu Ile  Val Asn Ser Tyr Gly  Ser Ser Glu Val Ala  Gly Asp Val 
    1820                 1825                 1830             


Leu Ala  Gly Val Gln Asp Asp  Ala Gly Ile Thr Leu  Gly Ala Ala 
    1835                 1840                 1845             


Val Pro  Gly Ala Gly Ile Arg  Ile Leu Asp Ser Arg  Leu Arg Gln 
    1850                 1855                 1860             


Leu Pro  Ala Gly Val Ile Gly  Glu Ile Tyr Val Thr  Gly Gly Gln 
    1865                 1870                 1875             


Leu Ala  Arg Gly Tyr Leu Gly  Arg Pro Gly Gln Thr  Ala Thr Arg 
    1880                 1885                 1890             


Phe Val  Ala Ala Pro Gly Gly  Glu Arg Met Tyr Arg  Thr Gly Asp 
    1895                 1900                 1905             


Leu Gly  Ala Leu Leu Pro Gly  Gly Arg Val Val Phe  Ala Gly Arg 
    1910                 1915                 1920             


Ala Asp  Asp Gln Leu Lys Ile  Asn Gly His Arg Val  Glu Pro Gly 
    1925                 1930                 1935             


Glu Ile  Glu Ser Val Leu Ala  Arg Gln Pro Gly Val  Arg Glu Ala 
    1940                 1945                 1950             


Ala Val  Ile Gly Thr Gly Thr  Gln Leu Ala Ala Phe  Val Val Leu 
    1955                 1960                 1965             


Glu Ser  Asp Ala Pro Gly Ala  Gly Asp Leu Leu Thr  Ala Val Ser 
    1970                 1975                 1980             


Ala Glu  Leu Pro Gly His Leu  Val Pro Ser Ser Leu  Arg Pro Val 
    1985                 1990                 1995             


Asp Ala  Ile Pro Leu Leu Pro  Asn Gly Lys Arg Asp  Asn Asn Ala 
    2000                 2005                 2010             


Leu Arg  Ser Leu Leu Val Pro  Gly Glu Ser Thr Gly  Thr Ala Pro 
    2015                 2020                 2025             


Thr Asn  Asp Val Glu Arg Ala  Val Leu Asp Val Met  Thr Gly Val 
    2030                 2035                 2040             


Leu Gly  Arg Asp Pro Leu Gly  Ala Asp Asp Asp Phe  Phe Ala Val 
    2045                 2050                 2055             


Gly Gly  Asp Ser Ile Ser Ala  Ile Arg Val Thr Ser  Arg Leu Ala 
    2060                 2065                 2070             


Arg Ala  Gly Tyr His Ile Ala  Thr Glu Asp Val Phe  Arg Gly Arg 
    2075                 2080                 2085             


Thr Ala  Ala Gly Val Ala Ala  Leu Val Asp Thr Val  Glu Ser Leu 
    2090                 2095                 2100             


Ala His  Asp Ala Ala Ile Glu  Pro Phe Ala Thr Val  Arg Leu Ser 
    2105                 2110                 2115             


Pro Gln  Thr Ile Asp Arg Ile  Arg Glu Ser Gly Gln  Val Glu Asp 
    2120                 2125                 2130             


Ile Trp  Ala Met Ser Pro Leu  Gln Leu Gly Val Tyr  Tyr Gln Ser 
    2135                 2140                 2145             


Thr Leu  Ala Asp Ala Gly Pro  Thr Tyr Ile Ala Gln  Asn Val Phe 
    2150                 2155                 2160             


Glu Phe  Asp Arg Arg Ile Asp  Val Asp Ala Met Arg  Arg Ala Phe 
    2165                 2170                 2175             


Thr Ala  Leu Leu Arg Arg His  Pro Gln Leu Arg Ala  Gly Phe Arg 
    2180                 2185                 2190             


Thr Val  Glu His Ala Glu Pro  Glu Pro Ala Pro Asp  Ala Thr Pro 
    2195                 2200                 2205             


Val Val  Gln Val Val Val Thr  Asp Pro Pro Ser Asp  Leu Thr Val 
    2210                 2215                 2220             


Val Asp  Leu Thr Asp Gln Asp  Asp Pro Ala Ala Ala  Gln His Ile 
    2225                 2230                 2235             


Val Asp  Thr Asp Arg Thr Ala  Pro Phe Asp Val Ala  Thr Pro Pro 
    2240                 2245                 2250             


Leu Leu  Arg Leu Thr Val Ile  Arg Leu Pro Gly Gly  Arg Asp Arg 
    2255                 2260                 2265             


Met Leu  Phe Thr Tyr His Phe  Leu Leu Phe Asp Gly  Trp Ser Arg 
    2270                 2275                 2280             


Glu Leu  Val Leu Arg Asp Leu  Phe Ala Leu Tyr Asp  Ser Asp Ala 
    2285                 2290                 2295             


Gln His  Gly Ala Ile Ala Pro  His Gly Asp Leu Val  Val Arg His 
    2300                 2305                 2310             


Leu Gln  Trp Leu Ala Thr Asp  Gly Asp Pro Gln Ala  Ser Gly Ala 
    2315                 2320                 2325             


Arg Asp  Ala Trp Arg Asp Leu  Leu Ala Gly Leu Thr  Glu Pro Thr 
    2330                 2335                 2340             


Leu Ala  Ser Gly Val Ser Pro  Asp His Pro Asp Ala  Arg Pro Gly 
    2345                 2350                 2355             


Thr Glu  Pro Gly Arg Ile Val  Val Arg Val Pro Glu  Asp Val Thr 
    2360                 2365                 2370             


Thr Gln  Leu His Thr Cys Ala  Thr Ala His Gly Ala  Thr Leu Asn 
    2375                 2380                 2385             


Ser Val  Val Thr Ala Ala Val  Ala Leu Val Thr Gly  Tyr His Ala 
    2390                 2395                 2400             


Gly Thr  Thr Asp Val Val Ile  Gly Thr Thr Val Ala  Gly Arg Pro 
    2405                 2410                 2415             


Gly His  Leu Val Gly Ile Asp  Glu Thr Ile Gly Leu  Phe Leu Asn 
    2420                 2425                 2430             


Thr Val  Pro Val Arg Val Asp  Met Ser Pro Thr Arg  Ser Val Ala 
    2435                 2440                 2445             


Ala Ala  Met Ala Ser Ile Gly  Glu Gln Arg Val Ala  Met Met Arg 
    2450                 2455                 2460             


His Asp  His Leu Gly Leu Gly  Gln Ile Gln Arg Ala  Ala Gly Asp 
    2465                 2470                 2475             


Ser Gly  Ser Ala Leu Phe Asp  Ser Leu Leu Val Leu  Gln Asn Phe 
    2480                 2485                 2490             


Leu Asp  Asp Asp Thr Phe Thr  Asp Leu Glu Ser Arg  His Gly Ile 
    2495                 2500                 2505             


Val Asp  Val Ser Tyr His Asp  Thr Thr His Phe Pro  Leu Thr Trp 
    2510                 2515                 2520             


Val Leu  Thr Pro Gly Arg Glu  Leu Ala Ile Lys Leu  Glu His Arg 
    2525                 2530                 2535             


Val Val  Asp Asp Ala Arg Ala  Thr Glu Met Val Glu  Gln Leu Val 
    2540                 2545                 2550             


Thr Val  Leu Arg Thr Ile Ala  Ala Glu Pro Asp Thr  Ala Val Gly 
    2555                 2560                 2565             


Ala Val  Asp Leu Ile Gly Ala  Asp Arg Arg Ala Gln  Leu Glu Arg 
    2570                 2575                 2580             


Arg Trp  Ser Ser Thr Glu Arg  Pro Leu Glu Pro Val  Thr Ile Ala 
    2585                 2590                 2595             


Glu Leu  Leu Ala Arg Arg Ala  Glu Gln Asn Pro Asp  Asp Val Ala 
    2600                 2605                 2610             


Leu Val  Phe Gly Ala Gln Ser  Val Thr Tyr Arg Glu  Phe Asp Asp 
    2615                 2620                 2625             


Arg Val  Ser Gln Phe Ala Arg  His Leu Arg Ala Arg  Gly Ala Ala 
    2630                 2635                 2640             


Pro Glu  Thr Phe Val Ala Leu  Ala Leu Pro Arg Ser  Ile Asp Met 
    2645                 2650                 2655             


Val Val  Ala Leu Phe Ala Val  Leu Arg Ala Gly Ala  Ala Tyr Leu 
    2660                 2665                 2670             


Pro Leu  Glu Leu Asp Leu Pro  Ile Asp Arg Leu Arg  Thr Ile Ile 
    2675                 2680                 2685             


Asp Asn  Ala Glu Pro Val Leu  Leu Val Thr Thr Thr  Asp Arg Thr 
    2690                 2695                 2700             


Glu Leu  Ile Gly His Ala Arg  Ala Arg Gly Ala Asp  Val Ile Ala 
    2705                 2710                 2715             


Leu Asp  Asp Ala Glu Thr Ala  Ala Thr Leu Ala Asp  Thr Pro Ala 
    2720                 2725                 2730             


His Pro  Leu Thr Ala Gly Glu  Leu Gly Ala Phe Ala  Ser Asp Ser 
    2735                 2740                 2745             


Thr Arg  Leu Asn His Pro Ala  Tyr Leu Ile Tyr Thr  Ser Gly Ser 
    2750                 2755                 2760             


Thr Gly  Arg Pro Lys Gly Val  Leu Thr Gly Tyr Ala  Gly Leu Thr 
    2765                 2770                 2775             


Asn Met  Tyr Phe Asn His Arg  Glu Ala Ile Phe Ala  Pro Thr Val 
    2780                 2785                 2790             


Ala Arg  Ala Gly Ser Ala Glu  Gln Leu Arg Ile Ala  His Thr Val 
    2795                 2800                 2805             


Ser Phe  Ser Phe Asp Met Ser  Trp Glu Glu Leu Phe  Trp Leu Val 
    2810                 2815                 2820             


Glu Gly  His Gln Val His Val  Cys Asp Glu Glu Leu  Arg Arg Asp 
    2825                 2830                 2835             


Ala Pro  Ala Leu Val Ala Tyr  Cys His Arg His Arg  Ile Asp Val 
    2840                 2845                 2850             


Ile Asn  Val Thr Pro Thr Tyr  Ala His His Leu Phe  Asp Ala Gly 
    2855                 2860                 2865             


Leu Leu  Asp Asp Gly Ala His  Thr Pro Pro Leu Val  Leu Leu Gly 
    2870                 2875                 2880             


Gly Glu  Ala Val Gly Asp Gly  Val Trp Ser Ala Leu  Arg Asp His 
    2885                 2890                 2895             


Pro Asp  Ser Ala Gly Tyr Asn  Leu Tyr Gly Pro Thr  Glu Tyr Thr 
    2900                 2905                 2910             


Ile Asn  Thr Leu Gly Gly Gly  Thr Asp Asp Ser Asp  Thr Pro Thr 
    2915                 2920                 2925             


Val Gly  Gln Pro Ile Trp Asn  Thr Arg Gly Tyr Ile  Leu Asp Ala 
    2930                 2935                 2940             


Ala Leu  Arg Pro Val Pro Asp  Gly Ala Val Gly Glu  Leu Tyr Ile 
    2945                 2950                 2955             


Ala Gly  Thr Gly Leu Ala Leu  Gly Tyr His Arg Arg  Ala Gly Leu 
    2960                 2965                 2970             


Thr Ala  Ala Thr Met Val Ala  Asp Pro Tyr Val Pro  Gly Gly Arg 
    2975                 2980                 2985             


Met Tyr  Arg Thr Gly Asp Leu  Val Arg Arg Arg Pro  Gly Ser Ala 
    2990                 2995                 3000             


Glu Leu  Leu Asp Tyr Leu Gly  Arg Val Asp Asp Gln  Val Lys Ile 
    3005                 3010                 3015             


Arg Gly  Tyr Arg Val Glu Leu  Gly Glu Ile Glu Ser  Val Leu Thr 
    3020                 3025                 3030             


Arg Ala  Asp Gly Val Ala Arg  Cys Ala Val Val Ala  Arg Ala Thr 
    3035                 3040                 3045             


Gly Ala  Asn Pro Pro Val Lys  Thr Leu Ala Ala Tyr  Val Ile Pro 
    3050                 3055                 3060             


Asp Arg  Trp Pro Ala Glu Asp  Ala Ala Phe Ile Thr  Gly Leu Arg 
    3065                 3070                 3075             


Asp His  Leu Ala Arg Val Leu  Pro Gly Tyr Met Val  Pro Thr Arg 
    3080                 3085                 3090             


Tyr Gly  Ile Val Asp Thr Leu  Pro Leu Thr Ile Asn  Gly Lys Leu 
    3095                 3100                 3105             


Asp Val  Ala Ala Leu Pro Glu  Pro Ile Ala Ala Thr  Ser Gly Thr 
    3110                 3115                 3120             


Gly Arg  Thr Pro Arg Thr Asp  Arg Glu Ala Thr Leu  Leu Glu Ile 
    3125                 3130                 3135             


Val Ala  Ser Val Leu Gly Ile  Asp Gly Ile Gly Val  Asp Asp Asp 
    3140                 3145                 3150             


Phe Phe  Thr Leu Gly Gly Asp  Ser Ile Ser Ser Ile  Ser Val Cys 
    3155                 3160                 3165             


Gly Arg  Ala Arg Lys Ala Gly  Leu Asn Ile Thr Pro  Arg Asp Val 
    3170                 3175                 3180             


Phe Arg  Arg Arg Thr Ile Ala  Ala Leu Ala Ala Ser  Ala Asp Thr 
    3185                 3190                 3195             


Thr Gln  Thr Pro Glu Ser Gly  Pro Asp Thr Gly Thr  Gly Ala Ile 
    3200                 3205                 3210             


Thr Ala  Thr Pro Met Leu Ala  Glu Thr Ala Gln Ala  Asn Thr Pro 
    3215                 3220                 3225             


Leu Thr  Asn Phe Tyr Gln Ala  Met Val Leu Ala Thr  Pro Ala Gly 
    3230                 3235                 3240             


Ile Thr  Ala His Glu Val Gln  Arg Val Leu Gln Thr  Val Val Asp 
    3245                 3250                 3255             


Ala His  Ala Met Leu Arg Ala  Arg Leu Val Thr Thr  Ala Thr Gly 
    3260                 3265                 3270             


Trp Thr  Leu Thr Val Pro Asp  Gln Thr Ala Ala Ile  Gly Leu Thr 
    3275                 3280                 3285             


Val Arg  Ser Gly Ala Leu Thr  Ser Asp Cys Val Glu  Ala Glu Lys 
    3290                 3295                 3300             


Ala Ala  Ala Ala Ala Glu Leu  Asp Pro Arg Ala Gly  Asn Met Val 
    3305                 3310                 3315             


Arg Ala  Val Trp Phe Asp Ala  Pro Glu Ala Ser Gly  Gln Leu Leu 
    3320                 3325                 3330             


Leu Val  Ile His His Leu Val  Ile Asp Gly Val Ser  Trp Arg Ile 
    3335                 3340                 3345             


Leu Ser  Glu Asp Leu Ser Arg  Ala Trp Asn Asp Leu  Ala Ala Gly 
    3350                 3355                 3360             


Arg Asp  Val Ala Ala Asp Ala  Val Pro Thr Ser Phe  His Thr Trp 
    3365                 3370                 3375             


Ala Asn  Ala Leu Ala Gln Arg  Thr Phe Asp Asp Glu  Ser Glu Tyr 
    3380                 3385                 3390             


Trp Ala  Asp Val Leu Ala Thr  Pro Asp Pro Asp Leu  Gly Ser Arg 
    3395                 3400                 3405             


Pro Pro  Asp Pro Ala Ile Asp  Thr Ala Asp Thr Val  Arg Ser His 
    3410                 3415                 3420             


Glu Val  Thr Leu Ala Ser Asp  Val Thr Glu Ala Leu  Leu Thr Ser 
    3425                 3430                 3435             


Val Pro  Ala Ala Met His Gly  Gly Val Asn Asp Val  Leu Leu Thr 
    3440                 3445                 3450             


Gly Leu  Ala Val Ala Leu Ala  Gln Trp Arg Ala Asp  Arg Gly His 
    3455                 3460                 3465             


Ser Gln  Asn Thr Ala Ala Val  Ile Ser Leu Glu Gly  His Gly Arg 
    3470                 3475                 3480             


Glu Ser  Asp Leu Val Ala Ala  Asp Leu Asp Leu Ser  Arg Thr Val 
    3485                 3490                 3495             


Gly Trp  Phe Thr Ser Ile Tyr  Pro Val Arg Ile Asp  Pro Gly Pro 
    3500                 3505                 3510             


Leu Glu  Trp Asp Thr Val Arg  Ser Ala Gly Ala Glu  Leu Ala Ala 
    3515                 3520                 3525             


Ala Ala  Lys Ala Val Lys Glu  Gln Leu Arg Ala Val  Pro Asn Arg 
    3530                 3535                 3540             


Gly Leu  Gly Tyr Gly Val Leu  Arg His Leu His Gly  Ala Leu Asp 
    3545                 3550                 3555             


Gly Thr  Pro Pro Gln Ile Leu  Phe Asn Tyr Leu Gly  Arg Phe Thr 
    3560                 3565                 3570             


Gly Gly  Ser Gly Asn Asp Trp  Arg Pro Val Ala Gly  Ile Gly Ala 
    3575                 3580                 3585             


Leu Thr  Glu Gly Val Asp Pro  Ser Asn Pro Ala Met  Ser Leu Glu 
    3590                 3595                 3600             


Ile Asn  Ala Leu Ala Glu Glu  Arg Pro Asp Gly Thr  Val Leu Ser 
    3605                 3610                 3615             


Met Thr  Leu Ala Trp Pro Gly  Gly Leu Leu Asp Ala  Asp Asp Val 
    3620                 3625                 3630             


Ser Glu  Leu Gly Ser Met Trp  Ala Asp Val Leu Val  Ala Leu Thr 
    3635                 3640                 3645             


Arg Cys  Asp Ala Leu Arg Gly  His Thr Pro Ser Asp  Phe Gly Leu 
    3650                 3655                 3660             


Val Thr  Val Ser Gln Asp Asp  Ile Asp Gly Trp Asp  Arg Leu Gly 
    3665                 3670                 3675             


Glu Val  Glu Glu Val Leu Pro  Leu Leu Pro Leu Gln  Glu Gly Met 
    3680                 3685                 3690             


Tyr Phe  His Ser Met Phe Gly  Asp Pro Ala Thr Asp  Thr Tyr Arg 
    3695                 3700                 3705             


Val Gln  Gln Ile Ala Gln Leu  Ser Gly Pro Val Asp  Pro Glu Val 
    3710                 3715                 3720             


Leu Arg  Thr Ser Leu Thr Val  Val Met Arg Arg His  Gln Ala Leu 
    3725                 3730                 3735             


Arg Ala  Ser Phe Asn Glu Leu  Thr Asp Gly Arg Val  Ala Gln Val 
    3740                 3745                 3750             


Ile Trp  Ser Asp Val Pro Val  Gln Leu Thr Val Val  Asp Thr Asp 
    3755                 3760                 3765             


Asp Leu  Glu Ser Ile Ala Ala  Glu Glu Leu Ala Arg  Pro Phe Asn 
    3770                 3775                 3780             


Leu Ala  Glu Ala Pro Leu Val  Arg Tyr Met Leu Val  Arg Leu Gly 
    3785                 3790                 3795             


Asp Asp  Asp His Arg Leu Val  Gln Thr Met His His  Ile Ile Ala 
    3800                 3805                 3810             


Asp Gly  Trp Ser Tyr Pro Val  Leu Phe Gly Asp Ile  Val Asp His 
    3815                 3820                 3825             


Tyr Asn  Ala Ala Ile Gly Val  Gly Ser Ala Pro Gln  Pro Ile Thr 
    3830                 3835                 3840             


Val Thr  Leu Arg Asp His Ile  Glu Thr Val Thr Asp  Arg Asp Arg 
    3845                 3850                 3855             


Gly Ala  Ala Arg Gln Ala Trp  Glu Gln Ala Leu Ala  Gly Ala Glu 
    3860                 3865                 3870             


Pro Thr  Ala Leu Val Pro Arg  Pro Asp Gly Ala Pro  Val Gly Glu 
    3875                 3880                 3885             


His Arg  Ser Val Val Arg Arg  Leu Asp Ser Ala Arg  Thr Ala Ala 
    3890                 3895                 3900             


Val Gly  Arg Ala Ala Arg Val  His Gly Val Thr Val  Gly Thr Val 
    3905                 3910                 3915             


Leu His  Gly Ala Trp Gly Leu  Met Leu Gly Arg Leu  Leu Gly Arg 
    3920                 3925                 3930             


Asn Arg  Val Val Phe Gly Ser  Thr Val Ser Gly Arg  Gly Gly Asp 
    3935                 3940                 3945             


Leu Ala  Gly Thr Glu Ser Ile  Val Gly Leu Leu Ile  Asn Thr Ile 
    3950                 3955                 3960             


Pro Val  Pro Met Ser Trp Glu  Pro His Ala Thr Leu  Ala Ser Ala 
    3965                 3970                 3975             


Leu Ile  Asp Leu Gln Asp Gln  Gln Ser Ala Leu Leu  Asp Ala Gln 
    3980                 3985                 3990             


Gln Met  Gly Leu Ala Glu Leu  Ala Arg Leu Ala Gly  Val Arg Glu 
    3995                 4000                 4005             


Phe Phe  Asp Thr Met Val Ile  Val Glu Asn Phe Pro  Ser Thr Ser 
    4010                 4015                 4020             


Ser Ala  Glu His Thr Asp Pro  Arg Ala Val Ala Phe  Arg Gly Phe 
    4025                 4030                 4035             


Thr Gly  Thr Asp Ser Pro His  Tyr Pro Val Ser Phe  Val Ala Tyr 
    4040                 4045                 4050             


Ala Asp  Asp Gln Leu Thr Val  Glu Ile Lys Tyr Asp  Ala Gly Val 
    4055                 4060                 4065             


Val Thr  Pro Glu Gln Ala Glu  Arg Tyr Ala Glu Arg  Val Glu Arg 
    4070                 4075                 4080             


Ile Leu  Thr Ala Phe Ala Glu  Thr Pro Asp Leu Pro  Val Ser Arg 
    4085                 4090                 4095             


Ile Asp  Leu Arg Thr Asn Ala  Glu Arg Gln Phe Thr  Ala Gly His 
    4100                 4105                 4110             


Ala Ser  Arg Pro Gly Pro Gly  Arg Thr Leu Gly Ala  Ser Phe Ala 
    4115                 4120                 4125             


Glu Val  Ala Ala Thr Tyr Pro  Asp Ala Val Ala Val  Ser Cys Gly 
    4130                 4135                 4140             


Asp Thr  Arg Leu Thr Tyr Arg  Glu Leu Asp Asp Arg  Ala Ala Ala 
    4145                 4150                 4155             


Val Ala  Ala Thr Leu Ala Glu  Arg Gly Val Gly Ala  Glu Ser Arg 
    4160                 4165                 4170             


Val Ala  Ile Ala Leu Pro Arg  Ser Ala Asp Leu Ile  Val Ala Val 
    4175                 4180                 4185             


Leu Ala  Val Ile Lys Ala Gly  Gly Thr Tyr Val Pro  Ile Asp Ile 
    4190                 4195                 4200             


Gly Ala  Pro Ala Ala Arg Val  Gln His Ile Leu Ala  Asp Ser Ala 
    4205                 4210                 4215             


Pro Val  Cys Leu Leu Thr Asp  Thr Ala Glu Arg Phe  Thr Gly Val 
    4220                 4225                 4230             


Pro His  Val Ile Leu Ala Glu  Ala Ala Gln Asn Pro  Ala Arg Pro 
    4235                 4240                 4245             


Gln Ala  Pro Thr Val Ser Pro  Asp His Ala Ala Tyr  Val Ile Tyr 
    4250                 4255                 4260             


Thr Ser  Gly Ser Thr Gly Val  Pro Lys Gly Val Glu  Val Thr His 
    4265                 4270                 4275             


Arg Asn  Val Ala Ala Leu Phe  Ala Gly Thr Thr Ser  Gly Leu Tyr 
    4280                 4285                 4290             


Asp Phe  Gly Pro Asp Asp Val  Trp Thr Met Phe His  Ser Ala Ala 
    4295                 4300                 4305             


Phe Asp  Phe Ser Val Trp Glu  Leu Trp Gly Pro Leu  Leu His Gly 
    4310                 4315                 4320             


Gly Arg  Leu Val Val Val Glu  His Asp Val Ala Arg  Asp Pro Glu 
    4325                 4330                 4335             


Arg Phe  Val Asp Leu Leu Ala  Arg Glu Arg Val Thr  Val Leu Asn 
    4340                 4345                 4350             


Gln Thr  Pro Ser Ala Phe Tyr  Pro Leu Leu Glu Ala  Asp Ala Arg 
    4355                 4360                 4365             


Leu Arg  Arg Gln Leu Ala Leu  Arg Tyr Val Ile Phe  Gly Gly Glu 
    4370                 4375                 4380             


Ala Leu  Asp Val Arg Arg Leu  Ala Pro Trp Tyr Ala  Asn His Glu 
    4385                 4390                 4395             


Ser His  Ser Pro Arg Leu Val  Asn Met Tyr Gly Ile  Thr Glu Thr 
    4400                 4405                 4410             


Cys Val  His Val Ser His Arg  Ala Leu Asp Thr Ala  Asp Thr Gly 
    4415                 4420                 4425             


Ala Ala  Gly Ser Val Ile Gly  Gly Pro Leu Pro Gly  Leu Arg Ile 
    4430                 4435                 4440             


His Leu  Leu Asp Asn Asn Leu  Gln Pro Val Pro Ala  Gly Val Val 
    4445                 4450                 4455             


Gly Glu  Met Tyr Ile Ala Gly  Gly Gln Val Ala Arg  Gly Tyr Thr 
    4460                 4465                 4470             


Gly Arg  Pro Gly Leu Thr Ala  Thr Arg Phe Val Ala  Asn Pro Phe 
    4475                 4480                 4485             


Asp Gly  Ala Gly Glu Arg Leu  Tyr Arg Ser Gly Asp  Leu Ala Met 
    4490                 4495                 4500             


Trp Thr  Asp Ala Gly Glu Leu  Val Tyr Leu Gly Arg  Ser Asp Ala 
    4505                 4510                 4515             


Gln Val  Lys Val Arg Gly Tyr  Arg Ile Glu Leu Gly  Glu Val Glu 
    4520                 4525                 4530             


Ala Ala  Leu Val Thr Leu Pro  Gly Val Thr Asn Ala  Ala Ala Asp 
    4535                 4540                 4545             


Val Arg  His Asp Asp Thr Gly  Arg Ala Arg Leu Ile  Gly Tyr Val 
    4550                 4555                 4560             


Val Gly  Asp Ala Leu Asp Ile  Gly Ala Leu Arg Ser  Thr Leu Ala 
    4565                 4570                 4575             


Glu Arg  Leu Pro Asp Tyr Met  Val Pro Ser Val Leu  Leu Arg Leu 
    4580                 4585                 4590             


Asp Val  Leu Pro Leu Thr Val  Asn Gly Lys Leu Asp  Arg Ala Ala 
    4595                 4600                 4605             


Leu Pro  Asp Pro Glu Pro Val  Glu Gln Ala Pro Ala  Pro Val Ala 
    4610                 4615                 4620             


Gly Thr  Gly Thr Ala Ser Leu  Leu Ala Gly Leu Cys  Thr Glu Ile 
    4625                 4630                 4635             


Leu Gly  Thr Thr Val Gly Val  Glu Asp Asp Phe Phe  Thr Ala Gly 
    4640                 4645                 4650             


Gly Asp  Ser Ile Ile Ala Ile  Gln Leu Val Asn Arg  Ala Arg Arg 
    4655                 4660                 4665             


Glu Gly  Val Arg Ile Thr Pro  Gln Gln Val Phe Val  His Arg Thr 
    4670                 4675                 4680             


Pro Ala  Ala Leu Ala Ser Val  Leu Asp Thr Gly Ser  Val Ala Ala 
    4685                 4690                 4695             


Pro Asp  Ala Thr Pro Asp Glu  Asp Ala Gly Pro Asp  Leu Gly Glu 
    4700                 4705                 4710             


Val Met  Leu Thr Pro Ile Val  Gln Arg Leu Ala Glu  Leu Gly Gly 
    4715                 4720                 4725             


Thr Val  Thr Arg Phe Asn Gln  Ser Glu Leu Leu Arg  Thr Pro Ala 
    4730                 4735                 4740             


Gly Ala  Thr Val Ala Arg Leu  Glu Thr Ala Ile Asn  Ala Val Ile 
    4745                 4750                 4755             


Ala Arg  His Asp Ala Leu Arg  Ile Arg Leu His Arg  Pro Ala Pro 
    4760                 4765                 4770             


Met Leu  Trp Ser Leu Glu Thr  Thr Ala Ala Ala Pro  Val Ser Ile 
    4775                 4780                 4785             


Thr Arg  Ile Asp Ala His Gly  Phe Asp Asp Glu Gln  Leu Arg Thr 
    4790                 4795                 4800             


Val Ile  Ala Thr Glu Ser Asp  Ala Ala Ala Asp Arg  Leu Asp Pro 
    4805                 4810                 4815             


Glu Asn  Gly Val Val Val Val  Ala Val Trp Phe Asp  Arg Gly Thr 
    4820                 4825                 4830             


Asp Thr  Gln Gly Arg Leu Leu  Leu Val Val His His  Leu Ala Val 
    4835                 4840                 4845             


Asp Gly  Val Ser Trp Arg Ile  Leu Leu Asp Asp Leu  Ala Glu Ala 
    4850                 4855                 4860             


Tyr Arg  Gln Ala Leu Ser Gly  Gln Arg Val Ala Pro  Ala Pro Val 
    4865                 4870                 4875             


Thr Thr  Ser Leu Arg Gln Tyr  Ala Arg Thr Val Asn  Glu Asn Ala 
    4880                 4885                 4890             


Gln His  Ser Ser Arg Leu Thr  Glu Phe Glu His Trp  Thr Glu Val 
    4895                 4900                 4905             


Leu Ala  Pro Gly Gly Glu Leu  Val Ala Thr Ala Asp  Val Val Thr 
    4910                 4915                 4920             


Leu Thr  Val Gly Ala Thr Arg  Asp His Glu Ile Arg  Leu Ser Thr 
    4925                 4930                 4935             


Glu Asp  Thr Ala Pro Leu Leu  Thr Thr Val Pro Ala  Ala Ala Asn 
    4940                 4945                 4950             


Ala Asp  Val Thr Glu Thr Leu  Val Ala Ala Leu His  Leu Ala Val 
    4955                 4960                 4965             


Ser Arg  Trp Arg Ala Ala Arg  Gly Glu Ala Ala Asp  Ala Pro Leu 
    4970                 4975                 4980             


Val Leu  Ser Leu Glu Arg His  Gly Arg Asp Gly Trp  Pro Asp Asp 
    4985                 4990                 4995             


Val Asp  Leu Ser Arg Thr Val  Gly Trp Phe Thr Ser  Ile Ala Pro 
    5000                 5005                 5010             


Val Arg  Leu Pro Ala Pro Gly  Glu Asp Leu Leu Asn  Thr Leu Lys 
    5015                 5020                 5025             


Ala Val  Lys Glu Ser Leu Arg  Ala Ala Pro Asp Gly  Gly Leu Gly 
    5030                 5035                 5040             


Phe Gly  Gln Leu Arg Tyr Cys  Asn Pro Arg Thr Ser  Ala Val Leu 
    5045                 5050                 5055             


Ala Arg  Leu Gly Thr Pro Gln  Leu Leu Phe Asn Tyr  Leu Gly Arg 
    5060                 5065                 5070             


Trp Ala  Ala Asp Ala Cys Asp  Asp Trp Ala Ser Ala  Pro Glu Val 
    5075                 5080                 5085             


Asp Ala  Leu Arg Thr Glu Pro  Asn Pro Asp Leu Gly  Thr Pro Tyr 
    5090                 5095                 5100             


Leu Val  Glu Val Asn Ala Ile  Cys Asp Asp Thr Val  Asp Gly Pro 
    5105                 5110                 5115             


Arg Leu  Arg Ala Thr Leu Thr  Tyr Ala Asp Gly Glu  Leu Asp Glu 
    5120                 5125                 5130             


Pro Ser  Val Ala Glu Leu Gly  Glu Leu Trp Val Ala  Ala Leu Arg 
    5135                 5140                 5145             


Glu Leu  Gly Ser Leu Ala Thr  Gly Gly Asp Ala Ala  Leu Thr Pro 
    5150                 5155                 5160             


Ser Asp  Leu Pro Leu Val Thr  Leu Thr Gln Glu His  Ile Asp Arg 
    5165                 5170                 5175             


Val Thr  Gly Ala Val Pro Gly  Asn Val Glu Thr Ile  Trp Pro Leu 
    5180                 5185                 5190             


Ser Pro  Leu Gln Glu Gly Val  Tyr Leu Gln Ala Arg  Tyr Ala Thr 
    5195                 5200                 5205             


Ala Ala  Val Tyr Ile Val Gln  Asn Val Phe Asp Phe  Ala Glu Pro 
    5210                 5215                 5220             


Val Asp  Thr Thr Ala Leu Arg  Thr Ala Tyr Ser Ala  Val Met Ala 
    5225                 5230                 5235             


Arg Asn  Pro Val Leu Arg Ser  Ala Phe Trp Ala Asp  Asp Leu Pro 
    5240                 5245                 5250             


Gln Pro  Val Ala Ala Ile Val  Ala Asp Pro Val Cys  Glu Pro Arg 
    5255                 5260                 5265             


Val Val  Asp Leu Gly Gly Leu  Pro Ala Thr Gln Val  Glu Arg Arg 
    5270                 5275                 5280             


Val Glu  Glu Ile Thr Ala Asp  Asp Arg Gln Gln Thr  Phe Asp Leu 
    5285                 5290                 5295             


Ala Ala  Ala Pro Leu Ala Arg  Met Thr Val Leu Arg  Thr Pro Asp 
    5300                 5305                 5310             


Arg Asp  Arg Leu Ile Phe Ser  Tyr His Phe Leu Leu  Leu Asp Gly 
    5315                 5320                 5325             


Trp Ser  Arg Glu Gln Leu Leu  Arg Glu Leu Phe Ala  Glu Tyr Thr 
    5330                 5335                 5340             


Ala Ala  Arg Gly Gly Ala Val  Ala Gln Leu Pro Ala  Pro Thr Ala 
    5345                 5350                 5355             


Asp Phe  Thr Asp Tyr Leu Arg  Trp Leu Ala Arg Gln  Asp Arg Asp 
    5360                 5365                 5370             


Val Ser  Ala Arg Glu Trp Ser  Glu Ala Leu Arg Asp  Leu Glu Ala 
    5375                 5380                 5385             


Pro Thr  Leu Leu Val Pro Asp  Ala Val Gly Thr Asp  Pro Thr Leu 
    5390                 5395                 5400             


Ala Leu  Arg Leu Glu Phe Leu  Leu Ser Glu Ala Asp  Thr Ala Ala 
    5405                 5410                 5415             


Leu Thr  Ala Ala Ala Arg Ser  Ala Gly Val Thr Leu  Asn Ala Leu 
    5420                 5425                 5430             


Ile Ser  Thr Ala Leu Ala Met  Val Leu Ala Tyr Glu  Thr Gly Arg 
    5435                 5440                 5445             


Asp Asp  Val Val Phe Gly Ser  Thr Val Ala Gly Arg  Pro Thr Asp 
    5450                 5455                 5460             


Leu Asp  Gly Ile Asp Ser Val  Ile Gly Leu Phe Leu  Asn Thr Val 
    5465                 5470                 5475             


Pro Thr  Arg Val Arg Leu Ala  Pro His Arg Thr Val  Ala Asp Thr 
    5480                 5485                 5490             


Met Arg  Ala Val Gln Ser Asp  Arg Leu Arg Leu Met  Asp His Glu 
    5495                 5500                 5505             


Tyr Leu  Gly Leu Gly Asp Ile  Gln Arg Ala Val Ser  Thr Gly Gly 
    5510                 5515                 5520             


Gly Pro  Leu Phe Asp Ser Leu  Tyr Val Leu Gln Asn  Phe Leu Asp 
    5525                 5530                 5535             


Asp Asp  Thr Phe Thr Asp Met  Glu Ala Gln Tyr Gly  Ile Val Gly 
    5540                 5545                 5550             


His Asp  Ser Ile Asp Ala Ser  His Tyr Pro Leu Thr  Trp Val Ala 
    5555                 5560                 5565             


Ser Pro  Gly Arg Arg Leu Trp  Met Lys Leu Glu Tyr  Arg Pro Asp 
    5570                 5575                 5580             


Val Val  Glu Arg Asp Arg Ala  Gln Gly Leu Leu Asp  Arg Leu Arg 
    5585                 5590                 5595             


Gln Val  Leu Leu Gln Val Gly  Thr Gly Val Glu Arg  Pro Ser Ala 
    5600                 5605                 5610             


Ala Leu  Thr Leu Pro Leu Pro  Ala Glu Ala Asp His  Lys Arg Thr 
    5615                 5620                 5625             


Arg Asp  Ala Ala Thr Glu His  Asp Leu Pro His Ala  Ser Val Leu 
    5630                 5635                 5640             


Asp Leu  Leu Ala Glu Arg Ala  Val Gln Ser Gly Asp  Leu Thr Ala 
    5645                 5650                 5655             


Leu Val  Cys Gly Gly Glu Phe  Val Asp Tyr Ala Glu  Leu Leu Ala 
    5660                 5665                 5670             


Arg Val  Asn Arg Leu Ala Trp  Val Leu Arg Ser Arg  Gly Ile Gly 
    5675                 5680                 5685             


Pro Glu  Asp Thr Val Ala Leu  Ala Val Pro Arg Ser  Ile Asp Ala 
    5690                 5695                 5700             


Val Val  Ala Leu Phe Ala Val  Leu Arg Ala Gly Ala  Ala Tyr Leu 
    5705                 5710                 5715             


Pro Leu  Glu Leu Asp Tyr Pro  Asp Glu Arg Leu Ala  Val Met Leu 
    5720                 5725                 5730             


Gly Asp  Ala Glu Pro Val Arg  Val Leu Val Thr Gly  Ala Thr Ala 
    5735                 5740                 5745             


Gln Arg  Ile Ala Arg Val Ala  Ser Ala Pro Leu Thr  Val Leu Asp 
    5750                 5755                 5760             


Ala Pro  Asp Thr Cys Asp Glu  Leu Ala Arg Ala Arg  Ser Asp Trp 
    5765                 5770                 5775             


Asp Gly  Tyr Ser Pro His Pro  Asp Gln Pro Ala Tyr  Val Ile Tyr 
    5780                 5785                 5790             


Thr Ser  Gly Ser Thr Gly Lys  Pro Lys Gly Val Val  Thr Pro His 
    5795                 5800                 5805             


Arg Gly  Leu Thr Asn Met His  Leu Asn His Arg Glu  Ala Ile Phe 
    5810                 5815                 5820             


Ala Pro  Thr Ile Ala Arg Ala  His Gly Arg Arg Leu  Lys Ile Ala 
    5825                 5830                 5835             


His Thr  Val Ser Phe Ser Phe  Asp Met Ser Trp Glu  Glu Leu Leu 
    5840                 5845                 5850             


Trp Leu  Ile Glu Gly His Glu  Val His Ile Cys Asp  Glu Val Leu 
    5855                 5860                 5865             


Arg Arg  Asp Ala Thr Ser Leu  Val Arg Tyr Cys His  Asp His Arg 
    5870                 5875                 5880             


Ile Asp  Val Ile Asn Val Thr  Pro Thr Tyr Ala Ala  Leu Leu Phe 
    5885                 5890                 5895             


Glu Glu  Gly Leu Leu Glu Gln  Ala Gly His Pro Pro  Val Leu Val 
    5900                 5905                 5910             


Leu Leu  Gly Gly Glu Ala Val  Ser Thr Thr Val Trp  Asn Arg Leu 
    5915                 5920                 5925             


Arg Asp  Ser Glu Arg Trp Tyr  Gly Tyr Asn Leu Tyr  Gly Pro Thr 
    5930                 5935                 5940             


Glu Tyr  Thr Ile Asn Thr Leu  Gly Gly Gly Thr Asp  Asp Ser Ala 
    5945                 5950                 5955             


Thr Pro  Thr Val Gly Thr Pro  Ile Trp Asn Thr Arg  Ala His Ile 
    5960                 5965                 5970             


Leu Asp  Asn Trp Leu Arg Pro  Val Pro Asp Gly Val  Pro Gly Glu 
    5975                 5980                 5985             


Leu Tyr  Ile Ala Gly Ala Gly  Leu Ala Arg Gly Tyr  Leu Gly Gln 
    5990                 5995                 6000             


Pro Gly  Leu Thr Ala Ser Arg  Phe Val Ala Asn Pro  Phe Glu Pro 
    6005                 6010                 6015             


Gly Arg  Met Tyr Arg Thr Gly  Asp Leu Val Val Arg  Arg Ala Asp 
    6020                 6025                 6030             


Asp Asn  Ile Asp Phe Leu Gly  Arg Thr Asp Asp Gln  Val Lys Ile 
    6035                 6040                 6045             


Arg Gly  Tyr Arg Val Glu Leu  Gly Asp Ile Glu Ala  Ala Leu Val 
    6050                 6055                 6060             


Ser His  Pro Gly Val Ser Gln  Ala Ala Val Ile Ala  Arg Pro Asp 
    6065                 6070                 6075             


Thr Ala  Gly Ser Ser Arg Leu  Val Ala Tyr Val Val  Pro Thr Thr 
    6080                 6085                 6090             


Glu Asn  Pro Asp Val Leu Asp  Asp Leu Arg Met His  Leu Thr Ala 
    6095                 6100                 6105             


Thr Leu  Pro Ala Tyr Met Val  Pro Thr Ala Met Ala  Thr Leu Thr 
    6110                 6115                 6120             


Glu Ile  Pro Leu Thr Asp Asn  Gly Lys Leu Asp Thr  Arg Ala Leu 
    6125                 6130                 6135             


Pro Asp  Val Ala Pro Ile Gly  Arg His Gly Ala Gly  Arg Ala Pro 
    6140                 6145                 6150             


Gln Gly  Ala Val Glu Ala Thr  Leu Cys Ser Val Phe  Ala Glu Val 
    6155                 6160                 6165             


Leu Gly  Leu Asp Gly Pro Asp  Gly Leu Ser Val Asp  Asp Asp Phe 
    6170                 6175                 6180             


Phe Asp  Leu Gly Gly His Ser  Leu Leu Thr Ile Arg  Leu Ile Ser 
    6185                 6190                 6195             


Arg Ile  Arg Ser Glu Leu Gly  Ala Glu Leu Thr Leu  Gly Asp Val 
    6200                 6205                 6210             


Phe Asn  Ser Arg Thr Val Ala  Ala Leu Ala Arg His  Val Thr Ala 
    6215                 6220                 6225             


Asp Glu  Gly Asp Asn Arg Arg  Pro Arg Leu Val Ala  Gly Pro Arg 
    6230                 6235                 6240             


Pro Gln  His Ile Pro Ala Ser  Pro Ala Gln Arg Arg  Met Leu Met 
    6245                 6250                 6255             


Leu Asp  Arg Leu Gly Glu Thr  Gly Ser Ala Tyr Asn  Tyr Pro Leu 
    6260                 6265                 6270             


Val Phe  Arg Val Arg Gly Ala  Leu Asp Val Asp Ala  Leu Arg Asp 
    6275                 6280                 6285             


Ala Leu  Thr Ala Val Val Asp  Arg His Glu Ala Leu  Arg Thr Val 
    6290                 6295                 6300             


Phe Asp  Asp Arg Asp Gly Val  Tyr His Gln Arg Ile  Leu Pro Arg 
    6305                 6310                 6315             


Gly Thr  Gln Pro Pro Leu His  Val Ser Asp Cys Pro  Glu His Glu 
    6320                 6325                 6330             


Leu Ala  Thr Arg Ala Asp Ala  Leu Val Glu His Arg  Phe Asp Leu 
    6335                 6340                 6345             


Thr Gly  Glu Ile Pro Leu Arg  Val Asp Val Leu Arg  Ser Gly Pro 
    6350                 6355                 6360             


Glu Asp  His Thr Val Val Met  Leu Leu His His Ile  Ala Ile Asp 
    6365                 6370                 6375             


Glu Trp  Ser Asp Ala Val Phe  Leu Ala Asp Leu Asp  Ala Ala Tyr 
    6380                 6385                 6390             


Ala Ala  His Arg Ala Gly Thr  Ala Ala Pro Leu Pro  Glu Pro Val 
    6395                 6400                 6405             


Val Gln  Tyr Ala Asp His Thr  Leu Trp Gln Arg Asp  Val Leu Ala 
    6410                 6415                 6420             


Gln Leu  Gly Asp Arg Gln Arg  Glu Phe Trp Arg Thr  Ala Leu Ala 
    6425                 6430                 6435             


Gly Ala  Pro Asp Glu Leu Ala  Leu Pro Ala Asp Arg  Pro Arg Pro 
    6440                 6445                 6450             


Ala Arg  Pro Thr Gly Ala Gly  Gly Thr Leu Asp Val  Glu Ile Thr 
    6455                 6460                 6465             


Ala Glu  Thr Ala Ser Ala Leu  Arg Arg Leu Ala Ala  Asp Lys Gln 
    6470                 6475                 6480             


Val Ser  Met Leu Met Val Leu  His Ala Ala Val Ala  Val Leu Ile 
    6485                 6490                 6495             


His Arg  Leu Gly Ala Gly Asp  Asp Ile Val Val Gly  Thr Pro Val 
    6500                 6505                 6510             


Ala Gly  Arg Asp Asp Ala Ala  Leu Asp Asp Val Val  Gly Leu Phe 
    6515                 6520                 6525             


Val Asn  Thr Val Val Leu Arg  Ala Asp Leu Ala Gly  Asn Pro Thr 
    6530                 6535                 6540             


Phe Thr  Glu Leu Leu Asp Arg  Val Arg Thr Ala Asp  Leu Ala Ala 
    6545                 6550                 6555             


Phe Ala  His Gln Asp Leu Pro  Phe Asp His Leu Val  Glu Glu Leu 
    6560                 6565                 6570             


Asn Pro  Pro Arg Val Ala Gly  Arg Asn Pro Leu Phe  Asn Leu Phe 
    6575                 6580                 6585             


Val Gly  Tyr His Leu Arg Ser  Gly Thr Asp Ser Asp  Met Phe Gly 
    6590                 6595                 6600             


Leu Pro  Thr Glu Trp Thr Glu  Pro Ala Val Ser Ala  Ala Met Phe 
    6605                 6610                 6615             


Asp Leu  Gly Phe Thr Leu Val  Asp His Gly Gly Asp  Glu Ser Ala 
    6620                 6625                 6630             


Ser Ile  Thr Ala Glu Tyr Ala  Ala Asp Leu Phe Asp  Ala Ser Thr 
    6635                 6640                 6645             


Val His  Thr Leu Ala Arg Arg  Leu Val Ala Leu Leu  Asp His Val 
    6650                 6655                 6660             


Val Ala  Asp Ala Glu Thr Arg  Ile Gly Ala Leu Asp  Leu Leu Ala 
    6665                 6670                 6675             


Pro Gly  Glu His Asp Thr Leu  Val Val Glu His Asn  Ala Thr Glu 
    6680                 6685                 6690             


His Pro  Leu Glu Pro Ile Thr  Leu Gly Ala Leu Val  Ser Arg Gln 
    6695                 6700                 6705             


Ala Thr  Ser Thr Pro His Ala  Thr Ala Leu Arg Tyr  Glu Glu Ser 
    6710                 6715                 6720             


Glu Leu  Ser Tyr Arg Asp Leu  Asp Gly Trp Ser Asp  Arg Leu Ala 
    6725                 6730                 6735             


Ala His  Leu Ser Ala Arg Gly  Ala Ala Pro Gly Thr  Val Val Gly 
    6740                 6745                 6750             


Val Ser  Leu Pro Arg Ser Val  Glu Leu Val Val Ala  Leu Val Ala 
    6755                 6760                 6765             


Val Ala  Lys Ser Gly Ala Ala  Phe Leu Pro Leu Asp  Pro Glu Tyr 
    6770                 6775                 6780             


Pro Arg  Glu Arg Leu Glu Tyr  Met Val Ser Asp Ala  Arg Pro Ile 
    6785                 6790                 6795             


Thr Val  Leu Asp Asp Pro Asp  Ala Val Arg Arg Ser  Arg Gly Glu 
    6800                 6805                 6810             


Pro Asp  Gly Glu Leu Pro Arg  Ile Asp Pro Ala Ala  Trp Ala Tyr 
    6815                 6820                 6825             


Val Leu  Tyr Thr Ser Gly Ser  Thr Gly Arg Pro Lys  Gly Val Ala 
    6830                 6835                 6840             


Val Ala  His Ala Gly Ile Val  Asn Arg Ile Ala Cys  Leu Gln His 
    6845                 6850                 6855             


Ala Tyr  Pro Leu Gly Thr Asp  Asp Arg Met Leu Val  Lys Thr Pro 
    6860                 6865                 6870             


Ile Ser  Phe Asp Thr Ser Val  Trp Glu Val Phe Trp  Pro Leu Ser 
    6875                 6880                 6885             


Val Gly  Ala Thr Leu Val Val  Ala Arg Pro Gly Gly  His Arg Glu 
    6890                 6895                 6900             


Pro Ala  Tyr Leu Ala Ala Met  Ile Ala Glu Gln Cys  Val Thr Ala 
    6905                 6910                 6915             


Val Asp  Phe Val Pro Ser Met  Leu Glu Val Phe Leu  Asp Glu Val 
    6920                 6925                 6930             


Ala Gly  Thr Cys Ala Ser Leu  Thr Arg Val Thr Val  Gly Gly Glu 
    6935                 6940                 6945             


Ala Leu  Thr Thr Glu Leu Ala  Ala Arg Phe Ala Glu  Ala Phe Pro 
    6950                 6955                 6960             


Gly Val  Pro Leu His Asn Leu  Tyr Gly Pro Thr Glu  Ala Ala Val 
    6965                 6970                 6975             


Asp Val  Leu Gly Trp Thr Ala  Asp Gly Gly Pro Val  Ala Leu Gly 
    6980                 6985                 6990             


Val Pro  Gly Trp Asn Val Arg  Ala Tyr Val Leu Asp  Asp Tyr Leu 
    6995                 7000                 7005             


Asn Pro  Val Pro Ala Gly Ala  Pro Gly Glu Leu Tyr  Leu Ala Gly 
    7010                 7015                 7020             


Ile Gln  Leu Ala Asp Gly Tyr  Leu His Arg Gly Ala  Leu Thr Ala 
    7025                 7030                 7035             


Ala Arg  Phe Val Ala Ser Pro  Phe Asp Gln Gly Ala  Arg Met Tyr 
    7040                 7045                 7050             


Arg Thr  Gly Asp Val Val Arg  Trp Arg Ala Asp Gly  Gln Leu Glu 
    7055                 7060                 7065             


Tyr Leu  Gly Arg Ser Asp Asp  Gln Ile Lys Leu Arg  Gly Val Arg 
    7070                 7075                 7080             


Ile Glu  Pro Gly Glu Ile Glu  Thr Val Leu Ala Thr  His Pro Ala 
    7085                 7090                 7095             


Val Ser  Ser Val Arg Val Ile  Ala Arg Gly Gly Arg  Leu Met Ala 
    7100                 7105                 7110             


Tyr Tyr  Val Pro Ala Gly Val  Glu Ala Ser Ala Gly  Glu Leu Arg 
    7115                 7120                 7125             


Asp Glu  Leu Arg Glu His Ala  Ala Ala Ala Leu Pro  Ser His Met 
    7130                 7135                 7140             


Val Pro  Ser Gly Phe Val Ala  Leu Thr Glu Phe Pro  Leu Thr Pro 
    7145                 7150                 7155             


Ser Gly  Lys Leu Asp Arg Arg  Ala Leu Pro Glu Phe  Ala Gly Ala 
    7160                 7165                 7170             


Thr Ala  Gly Val Pro Gly Arg  Ala Pro Thr Thr Glu  Arg Gln His 
    7175                 7180                 7185             


Arg Leu  Cys Glu Leu Phe Ser  Asp Val Leu Gly Leu  Glu Val Thr 
    7190                 7195                 7200             


Gly Ile  Asp Asp Asp Phe Phe  Val Leu Gly Gly His  Ser Leu Leu 
    7205                 7210                 7215             


Leu Val  Arg Leu Ala Ala Ala  Leu Arg Arg Glu Phe  Ser Val Asp 
    7220                 7225                 7230             


Val Pro  Val Ala Asp Leu Met  Val Ser Pro Thr Val  Ala Asp Ile 
    7235                 7240                 7245             


Asp Gln  Arg Leu Asp Ala Ala  Gly Ser Ser Val Asp  Ser Leu Ala 
    7250                 7255                 7260             


Pro Val  Leu Pro Phe Arg Ala  Ser Gly Thr Asp Ala  Pro Leu Phe 
    7265                 7270                 7275             


Cys Val  His Pro Ala Ser Gly  Leu Ser Trp Gln Phe  Ala Gly Leu 
    7280                 7285                 7290             


Lys Arg  His Leu Pro Arg Gln  Ile Pro Ile Tyr Gly  Leu Gln Ser 
    7295                 7300                 7305             


Pro Leu  Phe Thr Gly Thr Pro  Leu Pro Glu Ser Ile  Ala Glu Leu 
    7310                 7315                 7320             


Thr Ala  Arg Tyr Ala Asp Thr  Ile Val Ala Val Ala  Pro Ser Gly 
    7325                 7330                 7335             


Pro Val  Arg Leu Leu Gly Trp  Ser Phe Gly Gly Ser  Met Ala Leu 
    7340                 7345                 7350             


Leu Ile  Ala Gln Glu Leu Ser  Arg Arg Gly Arg Glu  Val Thr Phe 
    7355                 7360                 7365             


Val Gly  Met Leu Asp Ala Arg  Thr Asp Thr Ala Asp  Pro Asn Ala 
    7370                 7375                 7380             


Gly Phe  Asp Pro Glu Ala Val  Leu Ala Gly Leu Leu  Arg Glu Met 
    7385                 7390                 7395             


Gly Phe  Gly Val Asp Pro Gln  Ala Arg Met Thr Val  Ala Asp Ala 
    7400                 7405                 7410             


Val Ala  Leu Val Arg Asp Thr  Asp Asp Ala Ile Thr  Val Leu Asp 
    7415                 7420                 7425             


Asp Glu  Gln Ile Ala Leu Val  Ile Glu Asn Tyr Val  Ala Ala Glu 
    7430                 7435                 7440             


Arg Leu  Thr Ala Asp Ala Asp  Tyr Gly Arg Tyr Asp  Gly Asp Val 
    7445                 7450                 7455             


Phe Phe  Val Asp Ala Thr Ile  Leu Glu Met Asp Leu  Ala Gly Val 
    7460                 7465                 7470             


Ala Ser  Arg Gly Trp His Asp  His Val Gly Gly Arg  Leu Lys Val 
    7475                 7480                 7485             


Ala Glu  Leu Asp Cys Arg His  Ser Glu Leu Met Asp  Ala Glu Val 
    7490                 7495                 7500             


Leu Glu  Arg Leu Gly Pro Leu  Ile Ala Ala Glu Leu  Arg Gly Gly 
    7505                 7510                 7515             


Asp Val  Ala Ser Gly 
    7520             


<210>  6
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Thr Leu Thr Thr Pro His Pro Arg Pro Glu Gln Ser Glu Ser Ala 
1               5                   10                  15      


Ala Gln Ser Ser Leu Leu Ala Gly Phe Thr Pro Phe Pro Ala Glu Arg 
            20                  25                  30          


Ala Gln Ala Tyr Arg Ala Ala Gly Tyr Trp Arg Asp Gln Leu Leu Asp 
        35                  40                  45              


Ser Val Leu Arg Thr Ala Ala Arg Thr Trp Pro Asp His Ile Ala Val 
    50                  55                  60                  


Ile Asp Ala Asp His Arg His Thr Tyr Ala Glu Leu Asp Arg Leu Ala 
65                  70                  75                  80  


Asp Arg Ala Ala Ala Gly Ile Ala Gly Leu Gly Ile Arg Pro Gly Asp 
                85                  90                  95      


Arg Val Leu Val Gln Leu Pro Asn Thr Ala Glu Phe Ala Val Ala Leu 
            100                 105                 110         


Phe Gly Leu Leu Arg Ala Gly Ala Val Pro Val Met Cys Leu Pro Gly 
        115                 120                 125             


His Arg Leu Ala Glu Leu Thr His Phe Ala Glu Val Ser Ser Ala Val 
    130                 135                 140                 


Ala Leu Val Val Ala Asp Thr Ala Gly Gly Phe Asp His Arg Asp Leu 
145                 150                 155                 160 


Ala Arg Glu Leu Val Arg Ser His Pro Asp Val Arg His Val Leu Val 
                165                 170                 175     


Asp Gly Asp Ala Ala Glu Phe Leu Ser Trp Ala Glu Val Thr Arg Ala 
            180                 185                 190         


Ala Pro Gly Pro Val Pro Glu Ile Ala Pro Asp Pro Ala Ala Pro Ala 
        195                 200                 205             


Leu Leu Leu Val Ser Gly Gly Thr Thr Gly Ala Pro Lys Leu Ile Pro 
    210                 215                 220                 


Arg Thr His Gln Asp Tyr Val Tyr Asn Ala Thr Ala Ser Ala Glu Leu 
225                 230                 235                 240 


Cys Arg Leu Thr Ala Asp Asp Val Tyr Leu Val Ala Leu Pro Ala Ala 
                245                 250                 255     


His Asn Phe Pro Leu Ala Cys Pro Gly Leu Leu Gly Ala Met Thr Val 
            260                 265                 270         


Gly Ala Thr Thr Val Phe Thr Thr Asp Pro Ser Pro Glu Ala Ala Phe 
        275                 280                 285             


Ala Ala Ile Asp Glu His Gly Val Thr Ala Thr Ala Leu Val Pro Ala 
    290                 295                 300                 


Leu Ala Lys Leu Trp Ala Gln Ala Cys Ala Trp Glu Pro Leu Ala Pro 
305                 310                 315                 320 


Lys Thr Leu Arg Leu Leu Gln Val Gly Gly Ala Lys Leu Ala Ala Pro 
                325                 330                 335     


Asp Ala Ala Leu Val Arg Gly Ala Leu Thr Pro Gly Leu Gln Gln Val 
            340                 345                 350         


Phe Gly Met Ala Glu Gly Leu Leu Asn Tyr Thr Arg Ile Gly Asp Pro 
        355                 360                 365             


Pro Glu Val Leu Glu Asn Thr Gln Gly Arg Pro Leu Ser Pro Asp Asp 
    370                 375                 380                 


Glu Ile Arg Ile Val Asp Glu Val Gly Asn Glu Val Pro Pro Gly Ala 
385                 390                 395                 400 


Glu Gly Glu Leu Leu Val Arg Gly Pro Tyr Thr Leu Asn Gly Tyr Phe 
                405                 410                 415     


Asn Ala Glu Ala Ala Asn Glu Arg Ser Phe Ser Pro Asp Gly Phe Tyr 
            420                 425                 430         


Arg Ser Gly Asp Arg Val Arg Arg Phe Ala Asp Gly Pro Leu Ala Gly 
        435                 440                 445             


Tyr Leu Glu Val Thr Gly Arg Ile Lys Asp Val Ile Val Arg Gly Gly 
    450                 455                 460                 


Glu Asn Val Ser Ala Leu Asp Leu Glu Glu His Leu Leu Thr His Pro 
465                 470                 475                 480 


Ser Val Trp Ala Ala Ala Ala Val Ala Leu Pro Asp Glu Phe Leu Gly 
                485                 490                 495     


Glu Lys Ile Cys Ala Val Val Val Phe Asn Gly Pro Pro Val Ser Leu 
            500                 505                 510         


Ala Glu Leu His Ala His Leu Glu Gln Arg Gly Val Ala Ala His Ser 
        515                 520                 525             


Arg Pro Asp Ala Leu Val Pro Met Pro Ser Leu Pro Thr Thr Ala Val 
    530                 535                 540                 


Gly Lys Ile Asp Lys Lys Ala Ile Val Arg Gln Leu Gly Gly 
545                 550                 555             


<210>  7
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
atgccaccga aggcggcaga tggccgccga cccagtcccg acggcggact gggtggcttt       60

gtaccgttcc ccgcggatcg ggccgcgtcg taccgggcgg ccggctattg gtcggggcga      120

accctggaca ccgtgctctc cgatgccgcg cggcgctggc ctgaccgcct cgcggtggcc      180

gacgccggtg atcgtcccgg ccacggcggc ctcagttacg ccgaactcga ccagcgggcc      240

gaccgggccg ccgcggcgct gcacggcctg ggcatcacgc caggcgaccg ggtactgctc      300

cagctgccaa acggctgcca gttcgcggtt gccctgttcg cgttattgcg ggcgggagcg      360

atcccagtga tgtgcctgcc cggtcaccgc gccgccgaat tgggccactt cgccgccgtc      420

agcgcggcca ccgggctggt ggtcgccgat gtggccagcg ggttcgacta tcggccgatg      480

gcgcgcgaac ttgttgccga tcaccccacc ctgcgccatg tcatcgtcga tggcgatccg      540

ggaccgttcg tgtcgtgggc gcagctgtgc gcccaggccg gcaccggttc gccggcaccg      600

ccggccgatc ccggatcgcc agcgctgctg ctggtctccg gcggcaccac tggcatgccc      660

aaactcattc cacgcaccca cgacgactac gtgttcaacg cgacggccag cgccgcactc      720

tgtcggctta gcgccgacga cgtctatctg gtggtgctgg ccgccggcca caatttcccg      780

ctggcctgcc cgggcctgct cggcgcgatg accgtcgggg ccaccgccgt gttcgccccc      840

gatcccagcc cggaggccgc cttcgccgcc atcgagcgcc acggtgtcac cgtcaccgcg      900

ttggttccgg cactggccaa actgtgggcc caatcctgtg agtgggagcc ggtgacaccg      960

aagtcactgc ggttgttgca ggttggcggg tccaagctag aacccgagga cgctcgccgg     1020

gtacgcaccg cgctcacccc gggcctgcag caggtgttcg gcatggcgga ggggctgctg     1080

aacttcaccc gcatcggcga cccacccgaa gtggtggagc acacccaggg gcggccacta     1140

tgcccggccg acgaactgcg catcgtcaac gccgatggtg agccggtggg gcccggggag     1200

gaaggcgaac tcttggtgcg cgggccctac acgctgaacg gctattttgc tgccgaacgc     1260

gacaacgagc gctgcttcga tccggacggc ttctaccgca gcggcgacct ggtccgccgc     1320

cgcgacgacg gcaatctggt ggtcaccggg cgcgtcaagg atgtcatctg ccgtgcggga     1380

gaaaccatcg ccgccagcga cctcgaagaa cagctgctga gccatccggc gatcttctcg     1440

gccgcggcgg tgggactacc tgaccagtat ctgggggaaa aaatctgcgc tgcagtcgtt     1500

ttcgctggag ctccgattac gcttgcggag ttgaacggct accttgaccg gcgtggtgtg     1560

gccgcgcata cgcgacccga ccagctggtc gcgatgccgg cgctgcccac aacgccgatc     1620

gggaagatcg acaaacgagc gatcgtccgc cagctcggca tcgcgacggg tcccgtgacg     1680

acccagcgct gccattga                                                   1698


<210>  8
<211>  1778
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
atgccgccga aagcggcgga tggtcgtcgt ccgagcccgg atggtggtct gggtggtttt       60

gtgccgttcc cggcggatcg tgcggcgagc taccgtgcgg cgggttattg gagcggccgt      120

accctggaca ccgtgctgag cgatgcggcg cgtcgttggc cggatcgtct ggcggttgcg      180

gatgcgggtg atcgtccggg ccacggtggc ctgagctacg cggaactgga ccagcgtgcg      240

gatcgtgctg cggcggcgct gcacggtctg ggtatcaccc cgggcgatcg tgtgctgctg      300

cagctgccga acggttgcca attcgcggtt gcgctgtttg cgctgctgcg tgcgggtgcg      360

attccggtga tgtgcctgcc gggtcatcgt gcggcggaac tgggtcactt tgcggcggtg      420

agcgcggcga ccggcctggt ggttgcggat gttgcgagcg gttttgatta tcgtccgatg      480

gcgcgtgagc tggttgcgga ccacccgacc ctgcgtcacg tgatcgttga cggtgatccg      540

ggtccgtttg ttagctgggc gcagctgtgc gcgcaagcgg gcaccggcag cccggctccg      600

ccggcggacc cgggcagccc ggcgctgctg ctggttagcg gcagctgtgc gcgcaagcgg      660

gcaccggcag cccggctccg ccggcggacc cgggcagccc ggcgctgctg ctggttagcg      720

gtggcaccac cggtatgccg aagctgattc cgcgtaccca cgacgattat gtgtttaacg      780

cgaccgcgag cgcggcgctg tgccgtctga gcgcggacga tgtttatctg gtggttctgg      840

cggcgggtca caactttccg ctggcgtgcc cgggtctgct gggtgcgatg accgtgggtg      900

cgaccgcggt ttttgcgccg gacccgagcc cggaggcggc gtttgcggcg attgaacgtc      960

acggtgttac cgttaccgcg ctggtgccgg cgctggcgaa actgtgggcg cagagctgcg     1020

agtgggaacc ggtgaccccg aagagcctgc gtctgctgca agttggtggc agcaaactgg     1080

agccggaaga tgcgcgtcgt gtgcgtaccg cgctgacccc gggcctgcag caagttttcg     1140

gtatggcgga aggcctgctg aactttaccc gtatcggtga cccgccggaa gtggttgaac     1200

acacccaagg tcgtccgctg tgcccggcgg acgagctgcg tattgtgaac gcggatggtg     1260

aaccggttgg tccgggcgag gaaggtgaac tgctggtgcg tggcccgtac accctgaacg     1320

gttatttcgc ggcggagcgt gacaacgaac gttgcttcga cccggatggt ttttaccgta     1380

gcggcgatct ggttcgtcgt cgtgacgatg gcaacctggt ggttaccggt cgtgtgaagg     1440

acgttatctg ccgtgcgggt gaaaccattg cggggagcga tctggaggaa cagctgctga     1500

gccatccggc gattttcagc gctgcggcgg ttggcctgcc ggaccaatac ctgggtgaaa     1560

aaatctgcgc ggcggtggtt tttgcgggtg cgccgattac cctggcggag ctgaacggct     1620

atctggaccg tcgtggtgtg gcggcgcaca cccgtccgga tcaactggtt gcgatgccgg     1680

cgctgccgac caccccgatc ggcaagattg ataaacgtgc gattgttcgt caactgggta     1740

ttgcgaccgg cccggttacc acccaacgct gccactaa                             1778


<210>  9
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
actttggtcg tcggattcct gctggtgcg                                         29


<210>  10
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
ctatccagaa gccacatccg cggtcacgtg cgagcgtcc                              39


<210>  11
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
acattggctt cgcgccatgg caccgatttt                                        30


<210>  12
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
cacgtgaccg cggatgtggc ttctggatag tggccggaa                              39


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
atcttctgaa cacgctcaag gc                                                22


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
aggtagttga acagcagttg cg                                                22


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
tagttaacga ggaaacccac atgccaccga                                        30


<210>  16
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
tagctagctc aatggcagcg ctgggtcgtc a                                      31


<210>  17
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
taccatgggc atgccgccga aagcggcgga t                                      31


<210>  18
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
taccatgggc agcagccatc atcatcatca tcacagc                                37


<210>  19
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
taccatgggc agcagccatc atcatcatca tcatcatcac agcagcggcc                  50


<210>  20
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
taccatgggc agcagccatc atcatcatca tcatcatcat catcacagca gcggcc           56


<210>  21
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
taccatgggc agcagccatc atcatcatca tcacagccgt gcgtggcgtc atccgcagtt       60

tggcggtcat catcatcatc atcacagcag cggcc                                  95


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
ccggatcctt agtggcagcg ttg                                               23


<210>  23
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
ccggatcctt agtggtggtg gtggtggtgc aggccgctgc tgtggcagcg ttgggtggta       60

ac                                                                      62


<210>  24
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
ccggatcctt agtggtggtg gtggtggtgg tggtgcaggc cgctgctgtg gcagcgttgg       60

gtggtaac                                                                68


<210>  25
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
ccggatcctt agtggtggtg gtggtggtgg tggtggtggt gcaggccgct gctgtggcag       60

cgttgggtgg taac                                                         74


