                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> IL-10-CONTAINING VACCINES AND USES THEREOF

<130> 070772-225610PC-1169568

<140> PCT/US2019/068097
<141> 2019-12-20

<150> 62/784,039
<151> 2018-12-21

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 4148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg gatcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtgaggaatt agctggcgcg     1200

ccttcccgcc accatgggcg tgagaaactc cgtcttgtca gggaagaaag cagatgaatt     1260

agaaaaaatt aggctacgac ccaacggaaa gaaaaagtac atgttgaagc atgtagtatg     1320

ggcagcaaat gaattagata gatttggatt agcagaaagc ctgttggaga acaaagaagg     1380

atgtcaaaaa atactttcgg tcttagctcc attagtgcca acaggctcag aaaatttaaa     1440

aagcctttat aatactgtct gcgtcatctg gtgcattcac gcagaagaga aagtgaaaca     1500

cactgaggaa gcaaaacaga tagtgcagag acacctagtg gtggaaacag gaaccaccga     1560

aaccatgccg aagacctctc gaccaacagc accatctagc ggcagaggag gaaactaccc     1620

agtacagcag atcggtggca actacgtcca cctgccactg tccccgagaa ccctgaacgc     1680

ttgggtcaag ctgatcgagg agaagaagtt cggagcagaa gtagtgccag gattccaggc     1740

actgtcagaa ggttgcaccc cctacgacat caaccagatg ctgaactgcg ttggagacca     1800

tcaggcggct atgcagatca tccgtgacat catcaacgag gaggctgcag attgggactt     1860

gcagcaccca caaccagctc cacaacaagg acaacttagg gagccgtcag gatcagacat     1920

cgcaggaacc acctcctcag ttgacgaaca gatccagtgg atgtaccgtc agcagaaccc     1980

gatcccagta ggcaacatct accgtcgatg gatccagctg ggtctgcaga aatgcgtccg     2040

tatgtacaac ccgaccaaca ttctagatgt aaaacaaggg ccaaaagagc catttcagag     2100

ctatgtagac aggttctaca aaagtttaag agcagaacag acagatgcag cagtaaagaa     2160

ttggatgact caaacactgc tgattcaaaa tgctaaccca gattgcaagc tagtgctgaa     2220

ggggctgggt gtgaatccca ccctagaaga aatgctgacg gcttgtcaag gagtaggggg     2280

gccgggacag aaggctagat taatggcaga agccctgaaa gaggccctcg caccagtgcc     2340

aatccctttt gcagcagccc aacagagggg accaagaaag ccaattaagt gttggaattg     2400

tgggaaagag ggacactctg caaggcaatg cagagcccca agaagacagg gatgctggaa     2460

atgtggaaaa atggaccatg ttatggccaa atgcccagac agacaggcgg gttttttagg     2520

ccttggtcca tggggaaaga agccccgcaa tttccccatg gctcaagtgc atcaggggct     2580

gatgccaact gctcccccag aggacccagc tgtggatctg ctaaagaact acatgcagtt     2640

gggcaagcag cagagagaaa agcagagaga aagcagagag aagccttaca aggaggtgac     2700

agaggatttg ctgcacctca attctctctt tggaggagac caggactaca aagacgatga     2760

cgacaagtag tagcctgcag gcccctctcc ctcccccccc cctaacgtta ctggccgaag     2820

ccgcttggaa taaggccggt gtgcgtttgt ctatatgtta ttttccacca tattgccgtc     2880

ttttggcaat gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg     2940

tctttcccct ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc     3000

tctggaagct tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc     3060

cccacctggc gacaggtgcc tctgcggcca aaagccacgt gtataagata cacctgcaaa     3120

ggcggcacaa ccccagtgcc acgttgtgag ttggatagtt gtggaaagag tcaaatggct     3180

ctcctcaagc gtattcaaca aggggctgaa ggatgcccag aaggtacccc attgtatggg     3240

atctgatctg gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg     3300

tctaggcccc ccgaaccacg gggacgtggt tttcctttga aaaacacgat gataaagcca     3360

ccatgcacag ctcagcactg ctctgttgcc tagtcctcct gactggggtg agggccagcc     3420

caggccaggg cacccagtct gagaacagct gcacccgctt cccaggcaac ctgcctcaca     3480

tgcttcgaga cctccgagat gccttcagca gagtgaagac tttctttcaa atgaaggatc     3540

agctggacaa catattgtta aaggagtcct tgctggagga ctttaagggt tacctgggtt     3600

gccaagcctt gtctgagatg atccagtttt acctggagga ggtgatgccc caagctgaga     3660

accacgaccc agacatcaag gagcatgtga actccctggg ggagaatctg aagaccctca     3720

ggctgaggct gcggcgctgt catcgatttc ttccctgtga aaacaagagc aaggccgtgg     3780

agcaggtgaa gaatgccttt agtaagctcc aagagaaagg cgtctacaaa gccatgagtg     3840

agtttgacat cttcatcaac tacatagaag cctacatgac aatgaagata caaaactgag     3900

acctgcagga cgccacagct ctgatcataa tcagccatac cacatttgta gaggttttac     3960

ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg     4020

ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     4080

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     4140

atgtatct                                                              4148


<210> 2
<211> 509
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Gly Val Arg Asn Ser Val Leu Ser Gly Lys Lys Ala Asp Glu Leu 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Asn Gly Lys Lys Lys Tyr Met Leu Lys 
            20                  25                  30          


His Val Val Trp Ala Ala Asn Glu Leu Asp Arg Phe Gly Leu Ala Glu 
        35                  40                  45              


Ser Leu Leu Glu Asn Lys Glu Gly Cys Gln Lys Ile Leu Ser Val Leu 
    50                  55                  60                  


Ala Pro Leu Val Pro Thr Gly Ser Glu Asn Leu Lys Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Cys Val Ile Trp Cys Ile His Ala Glu Glu Lys Val Lys His 
                85                  90                  95      


Thr Glu Glu Ala Lys Gln Ile Val Gln Arg His Leu Val Val Glu Thr 
            100                 105                 110         


Gly Thr Thr Glu Thr Met Pro Lys Thr Ser Arg Pro Thr Ala Pro Ser 
        115                 120                 125             


Ser Gly Arg Gly Gly Asn Tyr Pro Val Gln Gln Ile Gly Gly Asn Tyr 
    130                 135                 140                 


Val His Leu Pro Leu Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Leu 
145                 150                 155                 160 


Ile Glu Glu Lys Lys Phe Gly Ala Glu Val Val Pro Gly Phe Gln Ala 
                165                 170                 175     


Leu Ser Glu Gly Cys Thr Pro Tyr Asp Ile Asn Gln Met Leu Asn Cys 
            180                 185                 190         


Val Gly Asp His Gln Ala Ala Met Gln Ile Ile Arg Asp Ile Ile Asn 
        195                 200                 205             


Glu Glu Ala Ala Asp Trp Asp Leu Gln His Pro Gln Pro Ala Pro Gln 
    210                 215                 220                 


Gln Gly Gln Leu Arg Glu Pro Ser Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Ser Val Asp Glu Gln Ile Gln Trp Met Tyr Arg Gln Gln Asn Pro 
                245                 250                 255     


Ile Pro Val Gly Asn Ile Tyr Arg Arg Trp Ile Gln Leu Gly Leu Gln 
            260                 265                 270         


Lys Cys Val Arg Met Tyr Asn Pro Thr Asn Ile Leu Asp Val Lys Gln 
        275                 280                 285             


Gly Pro Lys Glu Pro Phe Gln Ser Tyr Val Asp Arg Phe Tyr Lys Ser 
    290                 295                 300                 


Leu Arg Ala Glu Gln Thr Asp Ala Ala Val Lys Asn Trp Met Thr Gln 
305                 310                 315                 320 


Thr Leu Leu Ile Gln Asn Ala Asn Pro Asp Cys Lys Leu Val Leu Lys 
                325                 330                 335     


Gly Leu Gly Val Asn Pro Thr Leu Glu Glu Met Leu Thr Ala Cys Gln 
            340                 345                 350         


Gly Val Gly Gly Pro Gly Gln Lys Ala Arg Leu Met Ala Glu Ala Leu 
        355                 360                 365             


Lys Glu Ala Leu Ala Pro Val Pro Ile Pro Phe Ala Ala Ala Gln Gln 
    370                 375                 380                 


Arg Gly Pro Arg Lys Pro Ile Lys Cys Trp Asn Cys Gly Lys Glu Gly 
385                 390                 395                 400 


His Ser Ala Arg Gln Cys Arg Ala Pro Arg Arg Gln Gly Cys Trp Lys 
                405                 410                 415     


Cys Gly Lys Met Asp His Val Met Ala Lys Cys Pro Asp Arg Gln Ala 
            420                 425                 430         


Gly Phe Leu Gly Leu Gly Pro Trp Gly Lys Lys Pro Arg Asn Phe Pro 
        435                 440                 445             


Met Ala Gln Val His Gln Gly Leu Met Pro Thr Ala Pro Pro Glu Asp 
    450                 455                 460                 


Pro Ala Val Asp Leu Leu Lys Asn Tyr Met Gln Leu Gly Lys Gln Gln 
465                 470                 475                 480 


Arg Glu Lys Gln Arg Glu Ser Arg Glu Lys Pro Tyr Lys Glu Val Thr 
                485                 490                 495     


Glu Asp Leu Leu His Leu Asn Ser Leu Phe Gly Gly Asp 
            500                 505                 


<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 4
<211> 178
<212> PRT
<213> Macaca mulatta

<400> 4
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr Arg 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro His Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Ile 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn His Asp Pro Asp Ile Lys Glu His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Ser Lys Leu Gln Glu Lys Gly Val Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Gln Asn 
        


<210> 5
<211> 1175
<212> DNA
<213> Cercopithecine herpesvirus 8

<400> 5
atgcggagga ggaggaggtc tttcggcatc atcgtcgccg gcgctatcgg aacactactc       60

atgatggcgg tggtcgtgct ttcagcccat gaccatgaac acaaagaagt accaccggcc      120

tgtgaccccg ttcacggtaa cttggcaggc atcttcaagg agttgcgggc gacctacgct      180

tccattagag aaggtttggt atgttaggca acgcagttct cggatgtcag tccggatcgg      240

aggagtcaca gtctgtcatg tgatgatata ttgcttaatt tttgttttgc agcaaaagaa      300

ggacacggtg tactacacat cgctgttcaa tgaccgcgtg ctccatgaaa tgctgagtcc      360

tatgggctgt cgcgtgacca atgaactcat ggaacattat ttagatggtg ttctgcctcg      420

agcaagtcat ttagactacg ataatagcac tctgaatggc ttacatgtgt ttgcttcatc      480

catgcaggcg ctgtatcagc acatgttaaa gtgtgtaagt gtttcaggtt cgataacccc      540

gcgatatgac acgtaaatag cgatatcgtg gcaccagacg tcagtcacag tcttccccgg      600

tcgagacgca tcttatatcg cgatatatcg cggattatcg cagtatgtag cgatatatcg      660

tgtcaaagca ctccgaacga cattctgatg acggctatcg ccttatgtcg cggtatatcg      720

cggaatatcg cagtatatcg cggttatgtc gcgacataac cgtcatgtcg cgactatcgc      780

cgcatatcgc cactatcgcg acttggcacc gtgccaacga tagtcgacct tagggtggtc      840

gtgtggtggt ggggggctgc ttgcggtttg caaaccggag aggtagcaca cgctgattgt      900

cggtttggaa gcgttgttta cacatgtctt tgtcttggca gcccgcgttg gcatgtactg      960

gcaaaacgcc agcttggatg tacttcttgg aggtggaaca caaggtcagt taaggttgcc     1020

aggtaggtta aaacgcagaa accattgttc taccggtttc ctaaaacgcc gttcaacgtg     1080

ttttgcagct caacccctgg aggggcacgg caaaagccgc ggccgaggct gaccttttgc     1140

tgaactactt ggaaacgttc ctgctgcagt tctga                                1175


<210> 6
<211> 1179
<212> DNA
<213> Cercopithecine herpesvirus 8

<400> 6
atgcggagga ggaggaggtc tttcggcatc atcgtcgccg gcgctatcgg aacactactc       60

atgatggcgg tggtcgtgct ttcagcccat gaacacaaag aagtaccacc ggcctgtgac      120

cccgttcacg gtaacttggc aggcatcttc aaggagttgc gggcgaccta cgcttccatt      180

agagaaggtt tggtatgtta ggcaacgcag ttctcggatg tcagtccgga tcggaggagt      240

cacagtctgt catgtgatga tatattgctt catttttgtt ttgcagcaaa agaaggacac      300

ggtgtactac acatcgctgt tcaatgaccg cgtgctccat gagatgctga gtcctatggg      360

ctgtcgcgtg accaacgaac tcatggaaca ttatttagat ggtgttctgc ctcgagcaag      420

tcatttagac tacgataata gcactctgaa tggcttacat gtgtttgctt catccatgca      480

ggcgctgtat cagcacatgt taaagtgtgt aagtgtttca ggttcgataa ccccgcgata      540

tgacacgtaa atagcgatat cgtggcacca gacgtcagtc acagtcttcc ccggtcgaga      600

cgcatcttat atcgcgatat atcgcggttt atcgcagtat gtcgcgatat atcgctccaa      660

aacactccgg atgactttct atcgccgaat atcacctcat atcgtcttat atcgcggtgt      720

atcgcgggtt atcgtcatat atcgcggtta tgtcgcgaca taaccgtcat gtcgcgacta      780

tcgccgcata tcgccactat cgcgacttgg cacggtgcca acaatagttg cctctagggt      840

ggtcgtgtgg tggtaggggg ctgcttacgg tttgcaaacc ggagaggtcg cacacgctga      900

ttgtcggttt ggaagcgttg tttacacatg tctttgtctt ggcagcccgc gttggcatgt      960

actggcaaaa cgccagcttg gatgtacttc ttggaggtgg aacacaaggt cagttaaggt     1020

tgccaggtag gttaaaacgc agaaaccatt gttctaccgg tttcctaaaa cgccgttcaa     1080

cgtgttttgc agctcaaccc ctggaggggc acggcaaaag ccgcggccga ggctgacctt     1140

ttgctgaact acttggaaac gttcctgctg cagttctga                            1179


<210> 7
<211> 178
<212> PRT
<213> Homo sapiens

<400> 7
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 8
<211> 3545
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg gatcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctgtcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtgaggaatt agctggcgcg     1200

ccttcccgcc accatgtctt ctgagcagaa gagtcagcac tgcaagcctg aggaaggcgt     1260

tgaggcccaa gaagaggccc tgggcctggt gggtgcacag gctcctacta ctgaggagca     1320

ggaggctgct gtctcctcct cctctcctct ggtccctggc accctggagg aagtgcctgc     1380

tgctgagtca gcaggtcctc cccagagtcc tcagggagcc tctgccttac ccactaccat     1440

cagcttcact tgctggaggc aacccaatga gggttccagc agccaagaag aggaggggcc     1500

aagcacctcg cctgacgcag agtccttgtt ccgagaagca ctcagtaaca aggtggatga     1560

gttggctcat tttctgctcc gcaagtatcg agccaaggag ctggtcacaa aggcagaaat     1620

gctggagaga gtcatcaaaa attacaagcg ctgctttcct gtgatcttcg gcaaagcctc     1680

cgagtccctg aagatgatct ttggcattga cgtgaaggaa gtggaccccg ccagcaacac     1740

ctacaccctt gtcacctgcc tgggcctttc ctatgatggc ctgctgggta ataatcagat     1800

ctttcccaag acaggccttc tgataatcgt cctgggcaca attgcaatgg agggcgacag     1860

cgcctctgag gaggaaatct gggaggagct gggtgtgatg ggggtgtatg atgggaggga     1920

gcacactgtc tatggggagc ccaggaaact gctcacccaa gattgggtgc aggaaaacta     1980

cctggagtac cggcaggtac ccggcagtaa tcctgcgcgc tatgagttcc tgtggggtcc     2040

aagggctctg gctgaaacca gctatgtgaa agtcctggag catgtggtca gggtcaatgc     2100

aagagttcgc attgcctacc catccctgcg tgaagcagct ttgttagagg aggaagaggg     2160

agtctgatag cctgcaggcc cctctccctc ccccccccct aacgttactg gccgaagccg     2220

cttggaataa ggccggtgtg cgtttgtcta tatgttattt tccaccatat tgccgtcttt     2280

tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct     2340

ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct     2400

ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc     2460

acctggcgac aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc     2520

ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc     2580

ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc     2640

tgatctgggg cctcggtgca catgctttac atgtgtttag tcgaggttaa aaaaacgtct     2700

aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgatgat aaagccacca     2760

tgcacagctc agcactgctc tgttgcctag tcctcctgac tggggtgagg gccagcccag     2820

gccagggcac ccagtctgag aacagctgca cccgcttccc aggcaacctg cctcacatgc     2880

ttcgagacct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc     2940

tggacaacat attgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc     3000

aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc     3060

acgacccaga catcaaggag catgtgaact ccctggggga gaatctgaag accctcaggc     3120

tgaggctgcg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc     3180

aggtgaagaa tgcctttagt aagctccaag agaaaggcgt ctacaaagcc atgagtgagt     3240

ttgacatctt catcaactac atagaagcct acatgacaat gaagatacaa aactgagacc     3300

tgcaggacgc cacagctctg atcataatca gccataccac atttgtagag gttttacttg     3360

ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat gcaattgttg     3420

ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt     3480

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg     3540

tatct                                                                 3545


<210> 9
<211> 3701
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg gatcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctgtcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtgaggaatt agctggcgcg     1200

ccttcccgcc accatgcctc gagctccaaa gcgtcagcgc tgcatgcctg aagaagatct     1260

tcaatcccaa agtgagacac agggcctcga gggtgcacag gctcccctgg ctgtggagga     1320

ggatgcttca tcatccactt ccaccagctc ctcttttcca tcctcttttc cctcctcctc     1380

ctcttcctcc tcctcctcct gctatcctct aataccaagc accccagagg aggtttctgc     1440

tgatgatgag acaccaaatc ctccccagag tgctcagata gcctgctcct ccccctcggt     1500

cgttgcttcc cttccattag atcaatctga tgagggctcc agcagccaaa aggaggagag     1560

tccaagcacc ctacaggtcc tgccagacag tgagtcttta cccagaagtg agatagatga     1620

aaaggtgact gatttggtgc agtttctgct cttcaagtat caaatgaagg agccgatcac     1680

aaaggcagaa atactggaga gtgtcataag aaattatgaa gaccacttcc ctttgttgtt     1740

tagtgaagcc tccgagtgca tgctgctggt ctttggcatt gatgtaaagg aagtggatcc     1800

cactggccac tcctttgtcc ttgtcacctc cctgggcctc acctatgatg ggatgctgag     1860

tgatgtccag agcatgccca agactggcat tctcatactt atcctaagca tagtcttcat     1920

agagggctac tgcacccctg aggaggtcat ctgggaagca ctgaatatga tggggctgta     1980

tgatgggatg gagcacctca tttatgggga gcccaggaag ctgctcaccc aagattgggt     2040

gcaggaaaac tacctggagt accggcaggt gcctggcagt gatcctgcac ggtatgagtt     2100

tctgtggggt ccaagggctc atgctgaaat taggaagatg agtctcctga aatttttggc     2160

caaggtaaat gggagtgatc caagatcctt cccactgtgg tatgaggagg ctttgaaaga     2220

tgaggaagag agagcccagg acagaattgc caccacagat gatactactg ccatggccag     2280

tgcaagttct agcgctacag gtagcttctc ctaccctgaa taatagcctg caggcccctc     2340

tccctccccc ccccctaacg ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt     2400

tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg cccggaaacc     2460

tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca aaggaatgca     2520

aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa gacaaacaac     2580

gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg     2640

ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt gccacgttgt     2700

gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca acaaggggct     2760

gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc ggtgcacatg     2820

ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc acggggacgt     2880

ggttttcctt tgaaaaacac gatgataaag ccaccatgca cagctcagca ctgctctgtt     2940

gcctagtcct cctgactggg gtgagggcca gcccaggcca gggcacccag tctgagaaca     3000

gctgcacccg cttcccaggc aacctgcctc acatgcttcg agacctccga gatgccttca     3060

gcagagtgaa gactttcttt caaatgaagg atcagctgga caacatattg ttaaaggagt     3120

ccttgctgga ggactttaag ggttacctgg gttgccaagc cttgtctgag atgatccagt     3180

tttacctgga ggaggtgatg ccccaagctg agaaccacga cccagacatc aaggagcatg     3240

tgaactccct gggggagaat ctgaagaccc tcaggctgag gctgcggcgc tgtcatcgat     3300

ttcttccctg tgaaaacaag agcaaggccg tggagcaggt gaagaatgcc tttagtaagc     3360

tccaagagaa aggcgtctac aaagccatga gtgagtttga catcttcatc aactacatag     3420

aagcctacat gacaatgaag atacaaaact gagacctgca ggacgccaca gctctgatca     3480

taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc ccacacctcc     3540

ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt     3600

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     3660

tgcattctag ttgtggtttg tccaaactca tcaatgtatc t                         3701


<210> 10
<211> 770
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210> 11
<211> 874
<212> PRT
<213> Macaca mulatta

<400> 11
Met Thr Ala Cys Pro Gly Gln Ala Gly Ala Gly Arg Gly Leu Ala Glu 
1               5                   10                  15      


Gly Ala Val Ile Gln Arg Phe Pro Glu Leu Arg Arg Arg Arg Pro Gly 
            20                  25                  30          


Gly Gly Ala Gly Gly Ser Asp Val Ala Ala Glu Gly Thr Ser Pro Asn 
        35                  40                  45              


Arg Ile Leu Asp Arg His Pro Gly Ser Ala Leu Ser Leu Pro Leu Gly 
    50                  55                  60                  


Ser Asp Lys Pro Ser Gly Leu Arg Glu Pro Arg Arg Pro Pro Pro Ala 
65                  70                  75                  80  


His Ala Gln Pro Arg Pro Leu Gly Leu Cys Trp Arg Asn Ser Arg Met 
                85                  90                  95      


Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu Gln 
            100                 105                 110         


Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln Phe 
        115                 120                 125             


Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser Lys 
    130                 135                 140                 


Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile Asp 
145                 150                 155                 160 


Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln His 
                165                 170                 175     


Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu Lys 
            180                 185                 190         


Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu Ser 
        195                 200                 205             


Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln Ala 
    210                 215                 220                 


Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu Glu 
225                 230                 235                 240 


Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln Lys 
                245                 250                 255     


Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr Lys 
            260                 265                 270         


Thr Leu Lys Ser Gln Gly Gly Gln Gly Val Ser Pro Ser Ser Ala Asp 
        275                 280                 285             


Met Gln Asp Leu Asn Gly Asn Asn Gln Ser Val Thr Arg Gln Lys Met 
    290                 295                 300                 


Gln Gln Leu Glu Gln Met Leu Thr Ala Leu Asp Gln Met Arg Arg Ser 
305                 310                 315                 320 


Ile Val Ser Glu Leu Ala Gly Leu Leu Ser Ala Met Glu Tyr Val Gln 
                325                 330                 335     


Lys Thr Leu Thr Asp Glu Glu Leu Ala Asp Trp Lys Arg Arg Gln Gln 
            340                 345                 350         


Ile Ala Cys Ile Gly Gly Pro Pro Asn Ile Cys Leu Asp Arg Leu Glu 
        355                 360                 365             


Asn Trp Ile Thr Ser Leu Ala Glu Ser Gln Leu Gln Thr Arg Gln Gln 
    370                 375                 380                 


Ile Lys Lys Leu Glu Glu Leu Gln Gln Lys Val Ser Tyr Lys Gly Asp 
385                 390                 395                 400 


Pro Ile Val Gln His Arg Pro Met Leu Glu Glu Arg Ile Val Glu Leu 
                405                 410                 415     


Phe Arg Asn Leu Met Lys Ser Ala Phe Val Val Glu Arg Gln Pro Cys 
            420                 425                 430         


Met Pro Met His Pro Asp Arg Pro Leu Val Ile Lys Thr Gly Val Gln 
        435                 440                 445             


Phe Thr Thr Lys Val Arg Leu Leu Val Lys Phe Pro Glu Leu Asn Tyr 
    450                 455                 460                 


Gln Leu Lys Ile Lys Val Cys Ile Asp Lys Asp Ser Gly Asp Val Ala 
465                 470                 475                 480 


Ala Leu Arg Gly Ser Arg Lys Phe Asn Ile Leu Gly Thr Asn Thr Lys 
                485                 490                 495     


Val Met Asn Met Glu Glu Ser Asn Asn Gly Ser Leu Ser Ala Glu Phe 
            500                 505                 510         


Lys His Leu Thr Leu Arg Glu Gln Arg Cys Gly Asn Gly Gly Arg Ala 
        515                 520                 525             


Asn Cys Asp Ala Ser Leu Ile Val Thr Glu Glu Leu His Leu Ile Thr 
    530                 535                 540                 


Phe Glu Thr Glu Val Tyr His Gln Gly Leu Lys Ile Asp Leu Glu Thr 
545                 550                 555                 560 


His Ser Leu Pro Val Val Val Ile Ser Asn Ile Cys Gln Met Pro Asn 
                565                 570                 575     


Ala Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Thr Asn Asn Pro Lys 
            580                 585                 590         


Asn Val Asn Phe Phe Thr Lys Pro Pro Ile Gly Thr Trp Asp Gln Val 
        595                 600                 605             


Ala Glu Val Leu Ser Trp Gln Phe Ser Ser Thr Thr Lys Arg Gly Leu 
    610                 615                 620                 


Ser Ile Glu Gln Leu Thr Thr Leu Ala Glu Lys Leu Leu Gly Pro Gly 
625                 630                 635                 640 


Val Asn Tyr Ser Gly Cys Gln Ile Thr Trp Ala Lys Phe Cys Lys Glu 
                645                 650                 655     


Asn Met Ala Gly Lys Gly Phe Ser Phe Trp Val Trp Leu Asp Asn Ile 
            660                 665                 670         


Ile Asp Leu Val Lys Lys Tyr Ile Leu Ala Leu Trp Asn Glu Gly Tyr 
        675                 680                 685             


Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Ile Leu Ser Thr 
    690                 695                 700                 


Lys Pro Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Lys Glu 
705                 710                 715                 720 


Gly Gly Val Thr Phe Thr Trp Val Glu Lys Asp Ile Ser Gly Lys Thr 
                725                 730                 735     


Gln Ile Gln Ser Val Glu Pro Tyr Thr Lys Gln Gln Leu Asn Asn Met 
            740                 745                 750         


Ser Phe Ala Glu Ile Ile Met Gly Tyr Lys Ile Met Asp Ala Thr Asn 
        755                 760                 765             


Ile Leu Val Ser Pro Leu Val Tyr Leu Tyr Pro Asp Ile Pro Lys Glu 
    770                 775                 780                 


Glu Ala Phe Gly Lys Tyr Cys Arg Pro Glu Ser Gln Glu His Pro Glu 
785                 790                 795                 800 


Ala Asp Pro Gly Ser Ala Ala Pro Tyr Leu Lys Thr Lys Phe Ile Cys 
                805                 810                 815     


Val Thr Pro Thr Thr Cys Ser Asn Thr Ile Asp Leu Pro Met Ser Pro 
            820                 825                 830         


Arg Thr Leu Asp Ser Leu Met Gln Phe Gly Asn Asn Gly Glu Gly Ala 
        835                 840                 845             


Glu Pro Ser Ala Gly Gly Gln Phe Glu Ser Leu Thr Phe Asp Met Glu 
    850                 855                 860                 


Leu Thr Ser Glu Cys Ala Thr Ser Pro Met 
865                 870                 


<210> 12
<211> 770
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Cys Thr Cys Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210> 13
<211> 874
<212> PRT
<213> Macaca mulatta

<400> 13
Met Thr Ala Cys Pro Gly Gln Ala Gly Ala Gly Arg Gly Leu Ala Glu 
1               5                   10                  15      


Gly Ala Val Ile Gln Arg Phe Pro Glu Leu Arg Arg Arg Arg Pro Gly 
            20                  25                  30          


Gly Gly Ala Gly Gly Ser Asp Val Ala Ala Glu Gly Thr Ser Pro Asn 
        35                  40                  45              


Arg Ile Leu Asp Arg His Pro Gly Ser Ala Leu Ser Leu Pro Leu Gly 
    50                  55                  60                  


Ser Asp Lys Pro Ser Gly Leu Arg Glu Pro Arg Arg Pro Pro Pro Ala 
65                  70                  75                  80  


His Ala Gln Pro Arg Pro Leu Gly Leu Cys Trp Arg Asn Ser Arg Met 
                85                  90                  95      


Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu Gln 
            100                 105                 110         


Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln Phe 
        115                 120                 125             


Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser Lys 
    130                 135                 140                 


Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile Asp 
145                 150                 155                 160 


Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln His 
                165                 170                 175     


Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu Lys 
            180                 185                 190         


Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu Ser 
        195                 200                 205             


Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln Ala 
    210                 215                 220                 


Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu Glu 
225                 230                 235                 240 


Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln Lys 
                245                 250                 255     


Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr Lys 
            260                 265                 270         


Thr Leu Lys Ser Gln Gly Gly Gln Gly Val Ser Pro Ser Ser Ala Asp 
        275                 280                 285             


Met Gln Asp Leu Asn Gly Asn Asn Gln Ser Val Thr Arg Gln Lys Met 
    290                 295                 300                 


Gln Gln Leu Glu Gln Met Leu Thr Ala Leu Asp Gln Met Arg Arg Ser 
305                 310                 315                 320 


Ile Val Ser Glu Leu Ala Gly Leu Leu Ser Ala Met Glu Tyr Val Gln 
                325                 330                 335     


Lys Thr Leu Thr Asp Glu Glu Leu Ala Asp Trp Lys Arg Arg Gln Gln 
            340                 345                 350         


Ile Ala Cys Ile Gly Gly Pro Pro Asn Ile Cys Leu Asp Arg Leu Glu 
        355                 360                 365             


Asn Trp Ile Thr Ser Leu Ala Glu Ser Gln Leu Gln Thr Arg Gln Gln 
    370                 375                 380                 


Ile Lys Lys Leu Glu Glu Leu Gln Gln Lys Val Ser Tyr Lys Gly Asp 
385                 390                 395                 400 


Pro Ile Val Gln His Arg Pro Met Leu Glu Glu Arg Ile Val Glu Leu 
                405                 410                 415     


Phe Arg Asn Leu Met Lys Ser Ala Phe Val Val Glu Arg Gln Pro Cys 
            420                 425                 430         


Met Pro Met His Pro Asp Arg Pro Leu Val Ile Lys Thr Gly Val Gln 
        435                 440                 445             


Phe Thr Thr Lys Val Arg Leu Leu Val Lys Phe Pro Glu Leu Asn Tyr 
    450                 455                 460                 


Gln Leu Lys Ile Lys Val Cys Ile Asp Lys Asp Ser Gly Asp Val Ala 
465                 470                 475                 480 


Ala Leu Arg Gly Ser Arg Lys Phe Asn Ile Leu Gly Thr Asn Thr Lys 
                485                 490                 495     


Val Met Asn Met Glu Glu Ser Asn Asn Gly Ser Leu Ser Ala Glu Phe 
            500                 505                 510         


Lys His Leu Thr Leu Arg Glu Gln Arg Cys Gly Asn Gly Gly Arg Ala 
        515                 520                 525             


Asn Cys Asp Ala Ser Leu Ile Val Thr Glu Glu Leu His Leu Ile Thr 
    530                 535                 540                 


Phe Glu Thr Glu Val Tyr His Gln Gly Leu Lys Ile Asp Leu Glu Thr 
545                 550                 555                 560 


His Ser Leu Pro Val Val Val Ile Ser Asn Ile Cys Gln Met Pro Asn 
                565                 570                 575     


Ala Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Thr Asn Asn Pro Lys 
            580                 585                 590         


Asn Val Asn Phe Phe Thr Lys Pro Pro Ile Gly Thr Trp Asp Gln Val 
        595                 600                 605             


Ala Glu Val Leu Ser Trp Gln Phe Ser Ser Thr Thr Lys Arg Gly Leu 
    610                 615                 620                 


Ser Ile Glu Gln Leu Thr Thr Leu Ala Glu Lys Leu Leu Gly Pro Gly 
625                 630                 635                 640 


Val Asn Tyr Ser Gly Cys Gln Ile Thr Trp Ala Lys Phe Cys Lys Glu 
                645                 650                 655     


Asn Met Ala Gly Lys Gly Phe Ser Phe Trp Val Trp Leu Asp Asn Ile 
            660                 665                 670         


Ile Asp Leu Val Lys Lys Tyr Ile Leu Ala Leu Trp Asn Glu Gly Tyr 
        675                 680                 685             


Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Ile Leu Ser Thr 
    690                 695                 700                 


Lys Pro Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Lys Glu 
705                 710                 715                 720 


Gly Gly Val Thr Phe Thr Trp Val Glu Lys Asp Ile Ser Gly Lys Thr 
                725                 730                 735     


Gln Ile Gln Ser Val Glu Pro Tyr Thr Lys Gln Gln Leu Asn Asn Met 
            740                 745                 750         


Ser Phe Ala Glu Ile Ile Met Gly Tyr Lys Ile Met Asp Cys Thr Cys 
        755                 760                 765             


Ile Leu Val Ser Pro Leu Val Tyr Leu Tyr Pro Asp Ile Pro Lys Glu 
    770                 775                 780                 


Glu Ala Phe Gly Lys Tyr Cys Arg Pro Glu Ser Gln Glu His Pro Glu 
785                 790                 795                 800 


Ala Asp Pro Gly Ser Ala Ala Pro Tyr Leu Lys Thr Lys Phe Ile Cys 
                805                 810                 815     


Val Thr Pro Thr Thr Cys Ser Asn Thr Ile Asp Leu Pro Met Ser Pro 
            820                 825                 830         


Arg Thr Leu Asp Ser Leu Met Gln Phe Gly Asn Asn Gly Glu Gly Ala 
        835                 840                 845             


Glu Pro Ser Ala Gly Gly Gln Phe Glu Ser Leu Thr Phe Asp Met Glu 
    850                 855                 860                 


Leu Thr Ser Glu Cys Ala Thr Ser Pro Met 
865                 870                 


<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      His tag


<220>
<221> MISC_FEATURE
<222> (1)...(10)
<223> This sequence may encompass 6-10 residues

<400> 14
His His His His His His His His His His 
1               5                   10  


