                         SEQUENCE LISTING

<110>  CentryMed Pharmaceutical Inc.
 
<120>  PROTEASE CLEAVABLE BISPECIFIC ANTIBODIES AND USES THEREOF

<130>  11023.1004 PCT

<160>  172   

<170>  PatentIn version 3.5

<210>  1
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-1 Heavy chain (SEQ ID NO:1):

<400>  1

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
    130                 135                 140                 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
            180                 185                 190         


Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys 
        195                 200                 205             


Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210>  2
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-1 Light chain (SEQ ID NO:2):

<400>  2

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    130                 135                 140                 


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
145                 150                 155                 160 


Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
                165                 170                 175     


Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp 
        195                 200                 205             


Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe 
    210                 215                 220                 


Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
                245                 250                 255     


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
            260                 265                 270         


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
        275                 280                 285             


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
    290                 295                 300                 


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
305                 310                 315                 320 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
                325                 330                 335     


Arg Gly Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            340                 345                 350         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        355                 360                 365             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    370                 375                 380                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
385                 390                 395                 400 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                405                 410                 415     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            420                 425                 430         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        435                 440                 445             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    450                 455                 460                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
465                 470                 475                 480 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                485                 490                 495     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            500                 505                 510         


Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys 
        515                 520                 525             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    530                 535                 540                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
545                 550                 555                 560 


Lys 
    


<210>  3
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-2 Heavy chain (SEQ ID NO:3):

<400>  3

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
    130                 135                 140                 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
            180                 185                 190         


Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys 
        195                 200                 205             


Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210>  4
<211>  561
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-2 Light chain (SEQ ID NO:4):

<400>  4

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Pro Leu Gly Leu Ala Arg Lys Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    130                 135                 140                 


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
145                 150                 155                 160 


Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
                165                 170                 175     


Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp 
        195                 200                 205             


Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe 
    210                 215                 220                 


Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
                245                 250                 255     


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
            260                 265                 270         


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
        275                 280                 285             


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
    290                 295                 300                 


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
305                 310                 315                 320 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
                325                 330                 335     


Arg Gly Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            340                 345                 350         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        355                 360                 365             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    370                 375                 380                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
385                 390                 395                 400 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                405                 410                 415     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            420                 425                 430         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        435                 440                 445             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    450                 455                 460                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
465                 470                 475                 480 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                485                 490                 495     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            500                 505                 510         


Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys 
        515                 520                 525             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    530                 535                 540                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
545                 550                 555                 560 


Lys 
    


<210>  5
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-12 Heavy chain (SEQ ID NO:5):

<400>  5

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
    130                 135                 140                 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
            180                 185                 190         


Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys 
        195                 200                 205             


Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210>  6
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-12 Light chain (SEQ ID NO:6):

<400>  6

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Leu Ser Gly Arg Ser Asp Asn His Gly Pro Leu Gly Leu Ala 
        115                 120                 125             


Arg Lys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser 
145                 150                 155                 160 


Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp 
                165                 170                 175     


Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln 
        195                 200                 205             


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
    210                 215                 220                 


Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg Thr Val Ala 
225                 230                 235                 240 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                245                 250                 255     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            260                 265                 270         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        275                 280                 285             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    290                 295                 300                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
305                 310                 315                 320 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                325                 330                 335     


Ser Phe Asn Arg Gly Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            340                 345                 350         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        355                 360                 365             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    370                 375                 380                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
385                 390                 395                 400 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                405                 410                 415     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            420                 425                 430         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        435                 440                 445             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    450                 455                 460                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
465                 470                 475                 480 


Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                485                 490                 495     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            500                 505                 510         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr 
        515                 520                 525             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    530                 535                 540                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
545                 550                 555                 560 


Ser Pro Gly Lys 
                


<210>  7
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iBiTE Heavy chain (SEQ ID NO:7):

<400>  7

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Met Ser Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Gly Pro Lys Leu Leu Ile Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Leu Asp Ser Phe Pro Phe Ser Phe Thr Phe Gly Pro Gly Thr Lys Val 
225                 230                 235                 240 


Asp Leu Lys Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro 
            260                 265                 270         


Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             


Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    290                 295                 300                 


Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln 
305                 310                 315                 320 


Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys Ser Thr 
                325                 330                 335     


Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    370                 375                 380                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
385                 390                 395                 400 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                405                 410                 415     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            420                 425                 430         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        435                 440                 445             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    450                 455                 460                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
465                 470                 475                 480 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                485                 490                 495     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            500                 505                 510         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        515                 520                 525             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    530                 535                 540                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
545                 550                 555                 560 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                565                 570                 575     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            580                 585                 590         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        595                 600                 605             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys 
    610                 615                 620                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
625                 630                 635                 640 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                645                 650                 655     


Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            660                 665                 670         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        675                 680                 685             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695                 700     


<210>  8
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iBiTE Light chain (SEQ ID NO:8):

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                245                 250                 255     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            260                 265                 270         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    290                 295                 300                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        355                 360                 365             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys 
        


<210>  9
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBiTE Heavy chain (SEQ ID NO:9):

<400>  9

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
    130                 135                 140                 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
            180                 185                 190         


Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys 
        195                 200                 205             


Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210>  10
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HBiTE Light chain (SEQ ID NO:10):

<400>  10

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
        115                 120                 125             


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
    130                 135                 140                 


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
145                 150                 155                 160 


Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
                165                 170                 175     


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            180                 185                 190         


Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
        195                 200                 205             


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly 
    210                 215                 220                 


Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                245                 250                 255     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            260                 265                 270         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        275                 280                 285             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    290                 295                 300                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
305                 310                 315                 320 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  11
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-1s  Heavy chain (SEQ ID NO:11):

<400>  11

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
    130                 135                 140                 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
            180                 185                 190         


Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys 
        195                 200                 205             


Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210>  12
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-1s  Light chain (SEQ ID NO:12):

<400>  12

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Gly Ser Leu 
            100                 105                 110         


Ser Gly Arg Ser Asp Asn His Gly Gly Gly Gly Ser Asp Ile Gln Met 
        115                 120                 125             


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
    130                 135                 140                 


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
145                 150                 155                 160 


Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
                165                 170                 175     


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            180                 185                 190         


Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
        195                 200                 205             


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly 
    210                 215                 220                 


Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                245                 250                 255     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            260                 265                 270         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        275                 280                 285             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    290                 295                 300                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
305                 310                 315                 320 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  13
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-1s1  Heavy chain (SEQ ID NO:13):

<400>  13

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
    130                 135                 140                 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
            180                 185                 190         


Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys 
        195                 200                 205             


Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210>  14
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-1s1  Light chain (SEQ ID NO:14):

<400>  14

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Gly Ser Gly 
            100                 105                 110         


Ser Gly Arg Ser Asp Asn His Gly Gly Gly Gly Ser Asp Ile Gln Met 
        115                 120                 125             


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
    130                 135                 140                 


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
145                 150                 155                 160 


Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
                165                 170                 175     


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            180                 185                 190         


Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
        195                 200                 205             


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly 
    210                 215                 220                 


Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                245                 250                 255     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            260                 265                 270         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        275                 280                 285             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    290                 295                 300                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
305                 310                 315                 320 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  15
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-1s2  Heavy chain (SEQ ID NO:15):

<400>  15

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
    130                 135                 140                 


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
            180                 185                 190         


Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys 
        195                 200                 205             


Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210>  16
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  proBiTE-1s2  Light chain (SEQ ID NO:16):

<400>  16

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Gly Ser Gly 
            100                 105                 110         


Gly Ser Arg Ser Asp Asn His Gly Gly Gly Gly Ser Asp Ile Gln Met 
        115                 120                 125             


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
    130                 135                 140                 


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
145                 150                 155                 160 


Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
                165                 170                 175     


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            180                 185                 190         


Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
        195                 200                 205             


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly 
    210                 215                 220                 


Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                245                 250                 255     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            260                 265                 270         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        275                 280                 285             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    290                 295                 300                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
305                 310                 315                 320 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  17
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dproBiTE-HE  Heavy chain (SEQ ID NO:17):

<400>  17

Leu Thr Ser Ile Ile Ser Ala Val Val Gly Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Thr 
            20                  25                  30          


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 
        35                  40                  45              


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Gln 
    50                  55                  60                  


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly 
65                  70                  75                  80  


Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            100                 105                 110         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Val Ala Arg 
        115                 120                 125             


Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
            180                 185                 190         


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        195                 200                 205             


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val Lys 
    210                 215                 220                 


Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys Ser Thr Ala Phe Leu 
225                 230                 235                 240 


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                245                 250                 255     


Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        275                 280                 285             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    290                 295                 300                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
305                 310                 315                 320 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                325                 330                 335     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            340                 345                 350         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        355                 360                 365             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Pro Pro Cys 
    370                 375                 380                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
385                 390                 395                 400 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                405                 410                 415     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            420                 425                 430         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        435                 440                 445             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    450                 455                 460                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
465                 470                 475                 480 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                485                 490                 495     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            500                 505                 510         


Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr 
        515                 520                 525             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    530                 535                 540                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
545                 550                 555                 560 


Leu His Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                565                 570                 575     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            580                 585                 590         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        595                 600         


<210>  18
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dproBiTE-HE  Light chain (SEQ ID NO:18):

<400>  18

Ser Ile Ala Thr Gly Met Val Gly Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Arg Ser Asp Asn His Asp Val Val Met Thr Gln Ser Pro 
            20                  25                  30          


Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
        35                  40                  45              


Ala Ser Gln Ser Met Ser Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Gly Pro Lys Leu Leu Ile Tyr Ala Thr Ser Thr Leu Gln Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Leu Asp Ser Phe Pro Phe Ser Phe Thr Phe Gly Pro Gly Thr 
        115                 120                 125             


Lys Val Asp Leu Lys Gly Ser Gly Ser Gly Arg Ser Asp Asn His Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
145                 150                 155                 160 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser 
                165                 170                 175     


Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys 
            180                 185                 190         


Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser 
    210                 215                 220                 


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 
225                 230                 235                 240 


Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg Thr 
                245                 250                 255     


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
            260                 265                 270         


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
        275                 280                 285             


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
    290                 295                 300                 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
305                 310                 315                 320 


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
                325                 330                 335     


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
            340                 345                 350         


Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Pro Cys Pro Ala Pro Glu 
        355                 360                 365             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    370                 375                 380                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
385                 390                 395                 400 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                405                 410                 415     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            420                 425                 430         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        435                 440                 445             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    450                 455                 460                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
465                 470                 475                 480 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                485                 490                 495     


Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            500                 505                 510         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        515                 520                 525             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys 
    530                 535                 540                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
545                 550                 555                 560 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                565                 570                 575     


Ser Leu Ser Pro Gly Lys 
            580         


<210>  19
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dproBiTE-GS  Heavy chain (SEQ ID NO:19):

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Thr 
            20                  25                  30          


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 
        35                  40                  45              


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Gln 
    50                  55                  60                  


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly 
65                  70                  75                  80  


Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            100                 105                 110         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Val Ala Arg 
        115                 120                 125             


Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
            180                 185                 190         


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        195                 200                 205             


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val Lys 
    210                 215                 220                 


Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys Ser Thr Ala Phe Leu 
225                 230                 235                 240 


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                245                 250                 255     


Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        275                 280                 285             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    290                 295                 300                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
305                 310                 315                 320 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                325                 330                 335     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            340                 345                 350         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        355                 360                 365             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Pro Pro Cys 
    370                 375                 380                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
385                 390                 395                 400 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                405                 410                 415     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            420                 425                 430         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        435                 440                 445             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    450                 455                 460                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
465                 470                 475                 480 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                485                 490                 495     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            500                 505                 510         


Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr 
        515                 520                 525             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    530                 535                 540                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
545                 550                 555                 560 


Leu His Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                565                 570                 575     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            580                 585                 590         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        595                 600         


<210>  20
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dproBiTE-GS  Light chain (SEQ ID NO:20):

<400>  20

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Arg Ser Asp Asn His Asp Val Val Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Ala Ser Gln Ser Met Ser Arg Trp Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile Tyr Ala Thr Ser Thr Leu 
65                  70                  75                  80  


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe Ser Phe Thr Phe Gly Pro 
        115                 120                 125             


Gly Thr Lys Val Asp Leu Lys Gly Ser Gly Ser Gly Arg Ser Asp Asn 
    130                 135                 140                 


His Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
                165                 170                 175     


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
            180                 185                 190         


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile 
    210                 215                 220                 


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
225                 230                 235                 240 


Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
                245                 250                 255     


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
            260                 265                 270         


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
        275                 280                 285             


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
    290                 295                 300                 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
305                 310                 315                 320 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
                325                 330                 335     


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
            340                 345                 350         


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Pro Cys Pro Ala 
        355                 360                 365             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    370                 375                 380                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
385                 390                 395                 400 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                405                 410                 415     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            420                 425                 430         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        435                 440                 445             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    450                 455                 460                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
465                 470                 475                 480 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                485                 490                 495     


Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            500                 505                 510         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        515                 520                 525             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu His 
    530                 535                 540                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
545                 550                 555                 560 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                565                 570                 575     


Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 


<210>  21
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  23

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  24
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr 
1               5                   10          


<210>  25
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Val Asp Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Ile Ala Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Thr Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Thr Val Asp Ser Trp 
1               5       


<210>  27
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Thr Ser 
1           


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Gln Gly His Ile Ala Pro His Thr 
1               5                   


<210>  29
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  30
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  30

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys 
            100                 105                 


<210>  31
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Ser Met Ser Arg Trp 
1               5       


<210>  32
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala Thr Ser 
1           


<210>  33
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  33

Gln Gln Leu Asp Ser Phe Pro Phe Ser Phe Thr 
1               5                   10      


<210>  34
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Asn Gln Thr Ala Asp Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
                85                  90                  95      


Met Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  36
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Thr Ala Asp Ser Trp 
1               5       


<210>  37
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Ala Ser 
1           


<210>  38
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Gln Ser Tyr Ser Thr Pro Phe Met Phe Thr 
1               5                   10      


<210>  39
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  40
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ala Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Tyr Asp Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Asp Thr Phe Leu Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  41

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  42
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Ala Ser 
1           


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Gln Tyr Asp Thr Phe Leu Trp Thr 
1               5                   


<210>  44
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  45
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Val Asp Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Ile Ala Pro His 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Thr Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  46
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  47
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  47

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  48
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  48

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  49
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Asn Gln Thr Ala Asp Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
                85                  90                  95      


Met Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  50
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of proBiTE-1s1sp (SEQ ID NO:50)

<400>  50

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
            180                 185                 190         


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
225                 230                 235                 240 


Ser Tyr Val Ser Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr 
                245                 250                 255     


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
            260                 265                 270         


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
        275                 280                 285             


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
    290                 295                 300                 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
305                 310                 315                 320 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
                325                 330                 335     


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
            340                 345                 350         


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    450                 455                 460                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser 
    530                 535                 540                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Pro Gly Lys 
            580             


<210>  51
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of proBiTE-1s1sp (SEQ ID NO:51)

<400>  51

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Gly Ser Gly 
            100                 105                 110         


Ser Gly Arg Ser Asp Asn His Gly Gly Gly Gly Ser Glu Ile Val Val 
        115                 120                 125             


Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr 
    130                 135                 140                 


Leu Ser Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala 
145                 150                 155                 160 


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
                165                 170                 175     


Gly Ala Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Leu Ser Gly Asp Glu Ala Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
        195                 200                 205             


Asp Phe Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val 
    210                 215                 220                 


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
                245                 250                 255     


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
            260                 265                 270         


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
        275                 280                 285             


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
305                 310                 315                 320 


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
                325                 330                 335     


Asn Arg Gly Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            340                 345                 350         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        355                 360                 365             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    370                 375                 380                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
385                 390                 395                 400 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                405                 410                 415     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            420                 425                 430         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        435                 440                 445             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    450                 455                 460                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
465                 470                 475                 480 


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                485                 490                 495     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            500                 505                 510         


Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp 
        515                 520                 525             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    530                 535                 540                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
545                 550                 555                 560 


Gly Lys 
        


<210>  52
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of proBiTE-1s1spg (SEQ ID NO:52)

<400>  52

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
            180                 185                 190         


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Gly Asn Phe Gly Ser 
225                 230                 235                 240 


Ser Tyr Val Ser Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr 
                245                 250                 255     


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
            260                 265                 270         


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
        275                 280                 285             


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
    290                 295                 300                 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
305                 310                 315                 320 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
                325                 330                 335     


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
            340                 345                 350         


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    450                 455                 460                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser 
    530                 535                 540                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Pro Gly Lys 
            580             


<210>  53
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of proBiTE-1s1spg (SEQ ID NO:53)

<400>  53

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Gly Ser Gly 
            100                 105                 110         


Ser Gly Arg Ser Asp Asn His Gly Gly Gly Gly Ser Glu Ile Val Val 
        115                 120                 125             


Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr 
    130                 135                 140                 


Leu Ser Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala 
145                 150                 155                 160 


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
                165                 170                 175     


Gly Ala Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Leu Ser Gly Asp Glu Ala Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
        195                 200                 205             


Asp Phe Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val 
    210                 215                 220                 


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
                245                 250                 255     


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
            260                 265                 270         


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
        275                 280                 285             


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
    290                 295                 300                 


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
305                 310                 315                 320 


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
                325                 330                 335     


Asn Arg Gly Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            340                 345                 350         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        355                 360                 365             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    370                 375                 380                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
385                 390                 395                 400 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                405                 410                 415     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            420                 425                 430         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        435                 440                 445             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    450                 455                 460                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
465                 470                 475                 480 


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                485                 490                 495     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            500                 505                 510         


Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp 
        515                 520                 525             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    530                 535                 540                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
545                 550                 555                 560 


Gly Lys 
        


<210>  54
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of iBiTE-sp (SEQ ID NO:54)

<400>  54

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Met Ser Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Gly Pro Lys Leu Leu Ile Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Leu Asp Ser Phe Pro Phe Ser Phe Thr Phe Gly Pro Gly Thr Lys Val 
225                 230                 235                 240 


Asp Leu Lys Gly Gly Gly Ser Ser Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
    290                 295                 300                 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
                325                 330                 335     


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
            340                 345                 350         


Gly Asn Ser Tyr Val Ser Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
        355                 360                 365             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    370                 375                 380                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
385                 390                 395                 400 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                405                 410                 415     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            420                 425                 430         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        435                 440                 445             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    450                 455                 460                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Pro Pro Cys Pro 
465                 470                 475                 480 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                485                 490                 495     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            500                 505                 510         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        515                 520                 525             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    530                 535                 540                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
545                 550                 555                 560 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                565                 570                 575     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            580                 585                 590         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        595                 600                 605             


Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro 
    610                 615                 620                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
625                 630                 635                 640 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                645                 650                 655     


His Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            660                 665                 670         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        675                 680                 685             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695         


<210>  55
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of iBiTE-sp (SEQ ID NO:55)

<400>  55

Glu Ile Val Val Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Thr Gly Ala Val Thr Thr 
            20                  25                  30          


Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Gly Leu Ile Gly Gly Ala Asn Lys Arg Ala Pro Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Ser Gly Asp Glu Ala Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Ala Leu Trp Tyr Ser 
                85                  90                  95      


Asn Leu Trp Val Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys Pro Pro Cys Pro Ala Pro Glu 
    210                 215                 220                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            260                 265                 270         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        275                 280                 285             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                325                 330                 335     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            340                 345                 350         


Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        355                 360                 365             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    370                 375                 380                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser Lys 
385                 390                 395                 400 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                405                 410                 415     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            420                 425                 430         


Ser Leu Ser Pro Gly Lys 
        435             


<210>  56
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of HBiTE-spg (SEQ ID NO:56)

<400>  56

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Val Ala Arg Gly Asp Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
            180                 185                 190         


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Gly Asn Phe Gly Ser 
225                 230                 235                 240 


Ser Tyr Val Ser Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr 
                245                 250                 255     


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
            260                 265                 270         


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
        275                 280                 285             


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
    290                 295                 300                 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
305                 310                 315                 320 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
                325                 330                 335     


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
            340                 345                 350         


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    450                 455                 460                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu His Ser 
    530                 535                 540                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Pro Gly Lys 
            580             


<210>  57
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of HBiTE-spg (SEQ ID NO:57)

<400>  57

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Met Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gly Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Phe Pro Phe 
                85                  90                  95      


Ser Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Leu Lys Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Val Thr Gln Ser 
        115                 120                 125             


Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
    130                 135                 140                 


Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Ala Asn 
                165                 170                 175     


Lys Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ser Gly 
            180                 185                 190         


Asp Glu Ala Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala 
        195                 200                 205             


Val Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gln 
    210                 215                 220                 


Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
                245                 250                 255     


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
            260                 265                 270         


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
        275                 280                 285             


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
    290                 295                 300                 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
305                 310                 315                 320 


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
                325                 330                 335     


Glu Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            340                 345                 350         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        355                 360                 365             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    370                 375                 380                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
385                 390                 395                 400 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                405                 410                 415     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            420                 425                 430         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        435                 440                 445             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    450                 455                 460                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu 
465                 470                 475                 480 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                485                 490                 495     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            500                 505                 510         


Asp Gly Ser Phe Phe Leu His Ser Lys Leu Thr Val Asp Lys Ser Arg 
        515                 520                 525             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    530                 535                 540                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker GGGGSLSGRSDNHGGGGS (SEQ ID NO:58)

<400>  58

Gly Gly Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  59
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker GGGGSGPLGLARKGGGGS (SEQ ID NO:59)

<400>  59

Gly Gly Gly Gly Ser Gly Pro Leu Gly Leu Ala Arg Lys Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  60
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker GGGGSLSGRSDNHGPLGLARK (SEQ ID NO:60)

<400>  60

Gly Gly Gly Gly Ser Leu Ser Gly Arg Ser Asp Asn His Gly Pro Leu 
1               5                   10                  15      


Gly Leu Ala Arg Lys 
            20      


<210>  61
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker GSLSGRSDNHGGGGS (SEQ ID NO:61)

<400>  61

Gly Ser Leu Ser Gly Arg Ser Asp Asn His Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker GSGSGRSDNHGGGGS (SEQ ID NO:62)

<400>  62

Gly Ser Gly Ser Gly Arg Ser Asp Asn His Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker, GSGGSRSDNHGGGGS (SEQ ID NO:63)

<400>  63

Gly Ser Gly Gly Ser Arg Ser Asp Asn His Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge sequence  DKTHTCPPCP (SEQ ID NO:64)

<400>  64

Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heterodimerization motif of human HER2 transmembrane domain 
       LTSIISAVVG, (SEQ ID NO:65)

<400>  65

Leu Thr Ser Ile Ile Ser Ala Val Val Gly 
1               5                   10  


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heterodimerization motif of human EGFR transmembrane domain 
       SIATGMVG, (SEQ ID NO:66)

<400>  66

Ser Ile Ala Thr Gly Met Val Gly 
1               5               


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker GGGGSGGGGSGRSDNH (SEQ ID NO:67)

<400>  67

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn His 
1               5                   10                  15      


<210>  68
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OKTVLF (sense) (SEQ ID NO:68)

<400>  68
ggtgtccact ccgacatcca gatgacccag                                        30


<210>  69
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OKTVLR (antisense) (SEQ ID NO:69)

<400>  69
tgcagccaca gttcgggtta tctgcaactt tg                                     32


<210>  70
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CKF1 (sense) (SEQ ID NO:70)

<400>  70
cgaactgtgg ctgcacca                                                     18


<210>  71
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CKR1 (antisense) (SEQ ID NO:71)

<400>  71
tgctgggcac ggtggacact ctcccctgtt g                                      31


<210>  72
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MFCPAF (sense) (SEQ ID NO:72)

<400>  72
ccaccgtgcc cagcacc                                                      17


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAAR (antisense) (SEQ ID NO:73)

<400>  73
cccgaggtcg acgctctc                                                     18


<210>  74
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OKT3VHF (sense) (SEQ ID NO:74)

<400>  74
gcaagcttat gtgagctcag gcggaggtgg ctctggcggt ggcggatcac aggtgcagct       60

ggtgcag                                                                 67


<210>  75
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OKT3VHR (antisense) (SEQ ID NO:75)

<400>  75
gcccttggtg gaggctgagg agactgtgag                                        30


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHCKF1MFCF (sense) (SEQ ID NO:76)

<400>  76
gcctccacca agggccca                                                     18


<210>  77
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHMFCR (antisense) (SEQ ID NO:77)

<400>  77
gatcgaattc ttatttaccc ggagacag                                          28


<210>  78
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bnIgG20H1 (sense) (SEQ ID NO:78)

<400>  78
gtgttctaga gccgccacca tggaatggag ctgggtcttt ctcttc                      46


<210>  79
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12VHF (sense) (SEQ ID NO:79)

<400>  79
gatgccagat gtgaggtgca gctggtggag                                        30


<210>  80
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12VHR (antisense) (SEQ ID NO:80)

<400>  80
gatcgagctc cctccacctg aggagacggt gaccag                                 36


<210>  81
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12VLF (sense) (SEQ ID NO:81)

<400>  81
ggtgtccact ccgatgttgt gatgactcag                                        30


<210>  82
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12VLR (antisense) (SEQ ID NO:82)

<400>  82
gatcggatcc ccctccacct ttgagatcca ctttgg                                 36


<210>  83
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bnIgG20L1 (sense) (SEQ ID NO:83)

<400>  83
gtgtaagctt accatgggtg tgcccactca ggtcctgggg ttgctg                      46


<210>  84
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHF (sense) (SEQ ID NO:84)

<400>  84
gatcggatcc ctgagtggaa ggagcgacaa ccacggcggt ggcggatcag acatccagat       60

gacccag                                                                 67


<210>  85
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHF1 (sense) (SEQ ID NO:85)

<400>  85
gatcggatcc ggacctctgg gcctcgctag gaagggcggt ggcggatcag acatccagat       60

gacccag                                                                 67


<210>  86
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHF2 (sense) (SEQ ID NO:86)

<400>  86
gatcggatcc ctgagtggaa ggagcgacaa ccacggacct ctgggcctcg ctaggaagga       60

catccagatg acccag                                                       76


<210>  87
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H12LR (antisense) (SEQ ID NO:87)

<400>  87
gatcggatcc tttgagatcc actttgg                                           27


<210>  88
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1S1F (sense) (SEQ ID NO:88)

<400>  88
gatcggatcc gggagtggaa ggagcgacaa ccac                                   34


<210>  89
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1S2F (antisense) (SEQ ID NO:89)

<400>  89
gatcggatcc gggggaagta ggagcgacaa ccacggc                                37


<210>  90
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEHR (antisense) (SEQ ID NO:90)

<400>  90
acttcccccg ccaccgctgc caccccctcc gccaaccacc gcagagatga tggacgtcag       60

acatctggca tctgtaag                                                     78


<210>  91
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEHF (sense) (SEQ ID NO:91)

<400>  91
agcggtggcg ggggaagtgg cggtggaggg agcgaggtgc agctggtgga g                51


<210>  92
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HEHR1 (antisense) (SEQ ID NO:92)

<400>  92
gatcgagctc cctccacctg aggagacggt gaccag                                 36


<210>  93
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HELR (antisense) (SEQ ID NO:93)

<400>  93
acttcccccg ccaccgctgc caccccctcc ccccaccatc ccagtggcga tggaggagtg       60

gacacctgta g                                                            71


<210>  94
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HELF (sense) (SEQ ID NO:94)

<400>  94
agcggtggcg ggggaagtgg aaggagcgac aaccacgatg ttgtgatgac tcag             54


<210>  95
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HELR1 (antisense) (SEQ ID NO:95)

<400>  95
gatcggatcc tttgagatcc actttgg                                           27


<210>  96
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSHR (antisense) (SEQ ID NO:96)

<400>  96
gctccctcca ccgccacttc ccccgccacc gctgccaccc cctccacatc tggcatctgt       60

aag                                                                     63


<210>  97
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSHF (sense) (SEQ ID NO:97)

<400>  97
agtggcggtg gagggagcgg gggcggaggt agtgggggag ggggatcgga ggtgcagctg       60

gtggag                                                                  66


<210>  98
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSLR (antisense) (SEQ ID NO:98)

<400>  98
gctccctcca ccgccacttc ccccgccacc gctgccaccc cctccggagt ggacacctgt       60

ag                                                                      62


<210>  99
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSLF (sense) (SEQ ID NO:99)

<400>  99
agtggcggtg gagggagcgg gggcggaggt agtggaagga gcgacaacca cgatgttgtg       60

atgactcag                                                               69


<210>  100
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER1HF (sense) (SEQ ID NO:100)

<400>  100
ggtgtccact ccgaggtgca gctggtggag                                        30


<210>  101
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER1HR (antisense) (SEQ ID NO:101)

<400>  101
gatcgagctc acggtgacca gggttcc                                           27


<210>  102
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER1LF (sense) (SEQ ID NO:102)

<400>  102
gatgccagat gtgacatcca gatgacccag                                        30


<210>  103
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER1LR (antisense) (SEQ ID NO:103)

<400>  103
gatcgaattc ttaacactct cccctgttg                                         29


<210>  104
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER12LF1 (sense) (SEQ ID NO:104)

<400>  104
gatgccagat gtgatgttgt gatgactcag                                        30


<210>  105
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER12LR1 (antisense) (SEQ ID NO:105)

<400>  105
tgtcccagat ccactgcc                                                     18


<210>  106
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER12LF2 (sense) (SEQ ID NO:106)

<400>  106
ggatctggga cagagttcac tctcacaatc ag                                     32


<210>  107
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ER13LF (sense) (SEQ ID NO:107)

<400>  107
gatgccagat gtgacatcca gttgacccag                                        30


<210>  108
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bnIgG20H1 (sense) (SEQ ID NO:108)

<400>  108
gtgttctaga gccgccacca tggaatggag ctgggtcttt ctcttc                      46


<210>  109
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bnIgG20L1 (sense) (SEQ ID NO:109)

<400>  109
gtgtaagctt accatgggtg tgcccactca ggtcctgggg ttgctg                      46


<210>  110
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP34HF (sense) (SEQ ID NO:110)

<400>  110
gatcgagctc agaggtgcag ctggtggag                                         29


<210>  111
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP34HR (antisense) (SEQ ID NO:111)

<400>  111
gcccttggtg gaggctgagg agacggtgac                                        30


<210>  112
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CFCF (sense) (SEQ ID NO:112)

<400>  112
gcctccacca agggccca                                                     18


<210>  113
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MFc7.2R1 (antisense) (SEQ ID NO:113)

<400>  113
gatcgaattc ttatttaccc ggagacaggg                                        30


<210>  114
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP34LF (sense) (SEQ ID NO:114)

<400>  114
ggtgtccact ccgaaatagt ggtgacgcag                                        30


<210>  115
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SP34LR (antisense) (SEQ ID NO:115)

<400>  115
tgcagccaca gttcgtttga tctccagctt gg                                     32


<210>  116
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CFCPAF (sense) (SEQ ID NO:116)

<400>  116
cgaactgtgg ctgcacca                                                     18


<210>  117
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAAR (antisense) (SEQ ID NO:117)

<400>  117
cccgaggtcg acgctctc                                                     18


<210>  118
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bnIgG20H1 (sense) (SEQ ID NO:118)

<400>  118
gtgttctaga gccgccacca tggaatggag ctgggtcttt ctcttc                      46


<210>  119
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SFPAF (sense) (SEQ ID NO:119)

<400>  119
gatcggatcc gggagtggaa ggagcgacaa ccacggcggt ggcggatcag aaatagtggt       60

gacgcag                                                                 67


<210>  120
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SFF (sense) (SEQ ID NO:120)

<400>  120
gatcgagctc aggcggaggt ggctctggcg gtggcggatc agaggtgcag ctggtggag        59


<210>  121
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VNFR (antisense) (SEQ ID NO:121)

<400>  121
cccgaagttt ccgtgtctcg cacagtaata tacggc                                 36


<210>  122
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bnIgG20L1 (sense) (SEQ ID NO:122)

<400>  122
gtgtaagctt accatgggtg tgcccactca ggtcctgggg ttgctg                      46


<210>  123
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VNFF (sense) (SEQ ID NO:123)

<400>  123
cacggaaact tcgggagttc ctacgtgtct tacttc                                 36


<210>  124
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HSPGF (antisense) (SEQ ID NO:124)

<400>  124
gatcggatcc gggggatccg gcggaggtgg ctctggcggt ggcggatcag aaatagtggt       60

gacg                                                                    64


<210>  125
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker (SEQ ID NO:125)

<400>  125
ggggsggggs ggggs                                                        15


<210>  126
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker (SEQ ID NO:126)

<400>  126
gggssggggs ggggs                                                        15


<210>  127
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker (SEQ ID NO:127)

<400>  127
gsggggsggg gs                                                           12


<210>  128
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:128)

<400>  128

Pro Leu Gly Leu Trp Ala 
1               5       


<210>  129
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:129)

<400>  129

Gly Pro Leu Gly Leu Trp Ala 
1               5           


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:130)

<400>  130

Gly Pro Leu Gly Leu Trp Ala Gln 
1               5               


<210>  131
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:131)

<400>  131

Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu 
1               5                   10          


<210>  132
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:132)

<400>  132

Gly Val Pro Asp Val Gly His Phe Ser Leu Phe Pro 
1               5                   10          


<210>  133
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:133)

<400>  133

Gly Val Pro Asp Val Gly Glu Phe Ser Leu Phe Pro 
1               5                   10          


<210>  134
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:134)

<400>  134

Gly Val Pro Asp Val Gly Asn Phe Ser Leu Phe Pro 
1               5                   10          


<210>  135
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:135)

<400>  135

Gly Val Pro Asp Val Gly Arg Phe Ser Leu Phe Pro 
1               5                   10          


<210>  136
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:136)

<400>  136

Gly Val Pro Asp Val Gly His Tyr Ser Leu Phe Pro 
1               5                   10          


<210>  137
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:137)

<400>  137

Gly Val Pro Asp Val Gly Glu Tyr Ser Leu Phe Pro 
1               5                   10          


<210>  138
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:138)

<400>  138

Gly Val Pro Asp Val Gly Asn Tyr Ser Leu Phe Pro 
1               5                   10          


<210>  139
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:139)

<400>  139

Gly Val Pro Asp Val Gly Arg Tyr Ser Leu Phe Pro 
1               5                   10          


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage sites for urokinase (uPA) (SEQ ID NO:140)

<400>  140

Pro Arg Phe Lys Ile Ile Gly Gly 
1               5               


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage sites for urokinase (uPA) (SEQ ID NO:141)

<400>  141

Pro Arg Phe Arg Ile Ile Gly Gly 
1               5               


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site for TGF-beta (SEQ ID NO:142)

<400>  142

Ser Ser Arg His Arg Arg Ala Leu Asp 
1               5                   


<210>  143
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site for plasminogen (SEQ ID NO:143)

<400>  143

Arg Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu 
1               5                   10                  


<210>  144
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site for staphylokinase: (SEQ ID NO:144)

<400>  144

Ser Ser Ser Phe Asp Lys Gly Lys Tyr Lys Lys Gly Asp Asp Ala 
1               5                   10                  15  


<210>  145
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage sites for factor Xa: (SEQ ID NO:145)

<400>  145

Ile Glu Gly Arg 
1               


<210>  146
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage sites for factor Xa (SEQ ID NO:146)

<400>  146

Ile Asp Gly Arg 
1               


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage sites for factor Xa (SEQ ID NO:147)

<400>  147

Gly Gly Ser Ile Asp Gly Arg 
1               5           


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site for human liver collagen: (SEQ ID NO:148)

<400>  148

Gly Pro Leu Gly Ile Ala Gly Ile 
1               5               


<210>  149
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site for human alpha-2M  (SEQ ID NO:149)

<400>  149

Gly Pro Glu Gly Leu Arg Val Gly 
1               5               


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage sites for human PZP: (SEQ ID NO:150)

<400>  150

Tyr Gly Ala Gly Leu Gly Val Val 
1               5               


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage sites for human PZP (SEQ ID NO:151)

<400>  151

Ala Gly Leu Gly Val Val Glu Arg 
1               5               


<210>  152
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage sites for human PZP (SEQ ID NO:152)

<400>  152

Ala Gly Leu Gly Ile Ser Ser Thr 
1               5               


<210>  153
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible motif (SEQ ID NO:153)

<400>  153

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  154
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  part of the human IgG1 hinge sequence  (SEQ ID NO:154)

<400>  154

Cys Pro Pro Cys Pro 
1               5   


<210>  155
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:155)

<400>  155

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Asp Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Ile Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  156
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:156)

<400>  156

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Phe Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  157
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:157)

<400>  157

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Leu Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  158
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:158)

<400>  158

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Met Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  159
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:159)

<400>  159

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  160
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:160)

<400>  160

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Phe Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  161
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:161)

<400>  161

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Asn Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Leu Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  162
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:162)

<400>  162

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu His Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  163
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:163)

<400>  163

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Lys Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  164
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:164)

<400>  164

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Ser Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  165
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:165)

<400>  165

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Gln Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  166
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:166)

<400>  166

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  167
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:167)

<400>  167

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Trp Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  168
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:168)

<400>  168

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Ala Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  169
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:169)

<400>  169

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Gly Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  170
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:170)

<400>  170

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Asn Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  171
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (SEQ ID NO:171)

<400>  171

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  172
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  172

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


His Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


