                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> TREATMENT OF NEURODEVELOPMENTAL DISORDERS

<130> 050759-520001WO

<140> PCT/US2019/067979
<141> 2019-12-20
<150> 62/783,963
<151> 2018-12-21
<160> 38    

<170> PatentIn version 3.5

<210> 1
<211> 555
<212> PRT
<213> Homo sapiens

<400> 1
Met Thr Leu Arg Ala Ala Val Phe Asp Leu Asp Gly Val Leu Ala Leu 
1               5                   10                  15      


Pro Ala Val Phe Gly Val Leu Gly Arg Thr Glu Glu Ala Leu Ala Leu 
            20                  25                  30          


Pro Arg Gly Leu Leu Asn Asp Ala Phe Gln Lys Gly Gly Pro Glu Gly 
        35                  40                  45              


Ala Thr Thr Arg Leu Met Lys Gly Glu Ile Thr Leu Ser Gln Trp Ile 
    50                  55                  60                  


Pro Leu Met Glu Glu Asn Cys Arg Lys Cys Ser Glu Thr Ala Lys Val 
65                  70                  75                  80  


Cys Leu Pro Lys Asn Phe Ser Ile Lys Glu Ile Phe Asp Lys Ala Ile 
                85                  90                  95      


Ser Ala Arg Lys Ile Asn Arg Pro Met Leu Gln Ala Ala Leu Met Leu 
            100                 105                 110         


Arg Lys Lys Gly Phe Thr Thr Ala Ile Leu Thr Asn Thr Trp Leu Asp 
        115                 120                 125             


Asp Arg Ala Glu Arg Asp Gly Leu Ala Gln Leu Met Cys Glu Leu Lys 
    130                 135                 140                 


Met His Phe Asp Phe Leu Ile Glu Ser Cys Gln Val Gly Met Val Lys 
145                 150                 155                 160 


Pro Glu Pro Gln Ile Tyr Lys Phe Leu Leu Asp Thr Leu Lys Ala Ser 
                165                 170                 175     


Pro Ser Glu Val Val Phe Leu Asp Asp Ile Gly Ala Asn Leu Lys Pro 
            180                 185                 190         


Ala Arg Asp Leu Gly Met Val Thr Ile Leu Val Gln Asp Thr Asp Thr 
        195                 200                 205             


Ala Leu Lys Glu Leu Glu Lys Val Thr Gly Ile Gln Leu Leu Asn Thr 
    210                 215                 220                 


Pro Ala Pro Leu Pro Thr Ser Cys Asn Pro Ser Asp Met Ser His Gly 
225                 230                 235                 240 


Tyr Val Thr Val Lys Pro Arg Val Arg Leu His Phe Val Glu Leu Gly 
                245                 250                 255     


Ser Gly Pro Ala Val Cys Leu Cys His Gly Phe Pro Glu Ser Trp Tyr 
            260                 265                 270         


Ser Trp Arg Tyr Gln Ile Pro Ala Leu Ala Gln Ala Gly Tyr Arg Val 
        275                 280                 285             


Leu Ala Met Asp Met Lys Gly Tyr Gly Glu Ser Ser Ala Pro Pro Glu 
    290                 295                 300                 


Ile Glu Glu Tyr Cys Met Glu Val Leu Cys Lys Glu Met Val Thr Phe 
305                 310                 315                 320 


Leu Asp Lys Leu Gly Leu Ser Gln Ala Val Phe Ile Gly His Asp Trp 
                325                 330                 335     


Gly Gly Met Leu Val Trp Tyr Met Ala Leu Phe Tyr Pro Glu Arg Val 
            340                 345                 350         


Arg Ala Val Ala Ser Leu Asn Thr Pro Phe Ile Pro Ala Asn Pro Asn 
        355                 360                 365             


Met Ser Pro Leu Glu Ser Ile Lys Ala Asn Pro Val Phe Asp Tyr Gln 
    370                 375                 380                 


Leu Tyr Phe Gln Glu Pro Gly Val Ala Glu Ala Glu Leu Glu Gln Asn 
385                 390                 395                 400 


Leu Ser Arg Thr Phe Lys Ser Leu Phe Arg Ala Ser Asp Glu Ser Val 
                405                 410                 415     


Leu Ser Met His Lys Val Cys Glu Ala Gly Gly Leu Phe Val Asn Ser 
            420                 425                 430         


Pro Glu Glu Pro Ser Leu Ser Arg Met Val Thr Glu Glu Glu Ile Gln 
        435                 440                 445             


Phe Tyr Val Gln Gln Phe Lys Lys Ser Gly Phe Arg Gly Pro Leu Asn 
    450                 455                 460                 


Trp Tyr Arg Asn Met Glu Arg Asn Trp Lys Trp Ala Cys Lys Ser Leu 
465                 470                 475                 480 


Gly Arg Lys Ile Leu Ile Pro Ala Leu Met Val Thr Ala Glu Lys Asp 
                485                 490                 495     


Phe Val Leu Val Pro Gln Met Ser Gln His Met Glu Asp Trp Ile Pro 
            500                 505                 510         


His Leu Lys Arg Gly His Ile Glu Asp Cys Gly His Trp Thr Gln Met 
        515                 520                 525             


Asp Lys Pro Thr Glu Val Asn Gln Ile Leu Ile Lys Trp Leu Asp Ser 
    530                 535                 540                 


Asp Ala Arg Asn Pro Pro Val Val Ser Lys Met 
545                 550                 555 


<210> 2
<211> 2290
<212> DNA
<213> Homo sapiens

<400> 2
gtgcccctcc ccctgcctct ttcccggcca gagtccagcc ttaacccggg cagagggcgg       60

agtcccgtta agggggtgtg gggaggaggc ggggccaggg caggggcggg gcagagccgg      120

gccaagctgg gcgggtcatg cgccctggcc ttcgcgcatc tcccaggtta gctgcgtgtc      180

cgggtgctag gctgcagacc cgccgccatg acgctgcgcg cggccgtctt cgaccttgac      240

ggggtgctgg cgctgccagc ggtgttcggc gtcctcggcc gcacggagga ggccctggcg      300

ctgcccagag gacttctgaa tgatgctttc cagaaagggg gaccagaggg tgccactacc      360

cggcttatga aaggagagat cacactttcc cagtggatac cactcatgga agaaaactgc      420

aggaagtgct ccgagaccgc taaagtctgc ctccccaaga atttctccat aaaagaaatc      480

tttgacaagg cgatttcagc cagaaagatc aaccgcccca tgctccaggc agctctcatg      540

ctcaggaaga aaggattcac tactgccatc ctcaccaaca cctggctgga cgaccgtgct      600

gagagagatg gcctggccca gctgatgtgt gagctgaaga tgcactttga cttcctgata      660

gagtcgtgtc aggtgggaat ggtcaaacct gaacctcaga tctacaagtt tctgctggac      720

accctgaagg ccagccccag tgaggtcgtt tttttggatg acatcggggc taatctgaag      780

ccagcccgtg acttgggaat ggtcaccatc ctggtccagg acactgacac ggccctgaaa      840

gaactggaga aagtgaccgg aatccagctt ctcaataccc cggcccctct gccgacctct      900

tgcaatccaa gtgacatgag ccatgggtac gtgacagtaa agcccagggt ccgtctgcat      960

tttgtggagc tgggctccgg ccctgctgtg tgcctctgcc atggatttcc cgagagttgg     1020

tattcttgga ggtaccagat ccctgctctg gcccaggcag gttaccgggt cctagctatg     1080

gacatgaaag gctatggaga gtcatctgct cctcccgaaa tagaagaata ttgcatggaa     1140

gtgttatgta aggagatggt aaccttcctg gataaactgg gcctctctca agcagtgttc     1200

attggccatg actggggtgg catgctggtg tggtacatgg ctctcttcta ccccgagaga     1260

gtgagggcgg tggccagttt gaatactccc ttcataccag caaatcccaa catgtcccct     1320

ttggagagta tcaaagccaa cccagtattt gattaccagc tctacttcca agaaccagga     1380

gtggctgagg ctgaactgga acagaacctg agtcggactt tcaaaagcct cttcagagca     1440

agcgatgaga gtgttttatc catgcataaa gtctgtgaag cgggaggact ttttgtaaat     1500

agcccagaag agcccagcct cagcaggatg gtcactgagg aggaaatcca gttctatgtg     1560

cagcagttca agaagtctgg tttcagaggt cctctaaact ggtaccgaaa catggaaagg     1620

aactggaagt gggcttgcaa aagcttggga cggaagatcc tgattccggc cctgatggtc     1680

acggcggaga aggacttcgt gctcgttcct cagatgtccc agcacatgga ggactggatt     1740

ccccacctga aaaggggaca cattgaggac tgtgggcact ggacacagat ggacaagcca     1800

accgaggtga atcagatcct cattaagtgg ctggattctg atgcccggaa cccaccggtg     1860

gtctcaaaga tgtagaacgc agcgtgtgcc cacgctcagc aggtgtgcca tccttccacc     1920

tgctggggca ccattcttag tatacagagg tggccttaca cacatcttgc atggatggca     1980

gcattgttct gaaggggttt gcagaaaaaa aagattttct ttacataaag tgaatcaaat     2040

ttgacattat tttagatccc agagaaatca ggtgtgatta gttctccagg catgaatgca     2100

tcgtcccttt atctgtaaga acccttagtg tcctgtaggg ggacagaatg gggtggccag     2160

gtggtgattt ctctttgacc aatgcatagt ttggcagaaa aatcagccgt tcatttagaa     2220

gaatcttagc agagattggg atgccttact caataaagct aagatgacta tgctgaaaaa     2280

aaaaaaaaaa                                                            2290


<210> 3
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
cagtgttcat tggccatgac tgg                                               23


<210> 4
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 4
guguucauug gccaugacut t                                                 21


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 5
agucauggcc aaugaacact t                                                 21


<210> 6
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
gaaaggctat ggagagtcat ctg                                               23


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 7
aaggcuaugg agagucauct t                                                 21


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 8
gaugacucuc cauagccuut t                                                 21


<210> 9
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
aaaggctatg gagagtcatc tgc                                               23


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 10
aggcuaugga gagucaucut t                                                 21


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 11
agaugacucu ccauagccut t                                                 21


<210> 12
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
caagcagtgt tcattggcca tga                                               23


<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 13
agcaguguuc auuggccaut t                                                 21


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 14
auggccaaug aacacugcut t                                                 21


<210> 15
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
cagcacatgg aggactggat tcc                                               23


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 16
gcacauggag gacuggauut t                                                 21


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 17
aauccagucc uccaugugct t                                                 21


<210> 18
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
ttcaagaga                                                                9


<210> 19
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
cagtgttcat tggccatgac tgg                                               23


<210> 20
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
gatccccgtg ttcattggcc atgactttca agagaagtca tggccaatga acacttttt        59


<210> 21
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
agctaaaaag tgttcattgg ccatgacttc tcttgaaagt catggccaat gaacacggg        59


<210> 22
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
gaaaggctat ggagagtcat ctg                                               23


<210> 23
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
gatccccaag gctatggaga gtcatcttca agagagatga ctctccatag ccttttttt        59


<210> 24
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
agctaaaaaa aggctatgga gagtcatctc tcttgaagat gactctccat agccttggg        59


<210> 25
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
aaaggctatg gagagtcatc tgc                                               23


<210> 26
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
gatccccagg ctatggagag tcatctttca agagaagatg actctccata gcctttttt        59


<210> 27
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
agctaaaaaa ggctatggag agtcatcatc tcttgaaaga tgactctcca tagcctggg        59


<210> 28
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
caagcagtgt tcattggcca tga                                               23


<210> 29
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
gatccccagc agtgttcatt ggccatttca agagaatggc caatgaacac tgctttttt        59


<210> 30
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
agctaaaaaa gcagtgttca ttggccattc tcttgaaatg gccaatgaac actgctggg        59


<210> 31
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
cagcacatgg aggactggat tcc                                               23


<210> 32
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
gatccccgca catggaggac tggattttca agagaaatcc agtcctccat gtgcttttt        59


<210> 33
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
agctaaaaag cacatggagg actggatttc tcttgaaaat ccagtcctcc atgtgcggg        59


<210> 34
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
uguccagugc ccacaguccu                                                   20


<210> 35
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
uucccaccug acacgacucu                                                   20


<210> 36
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
guucagccuc agccacuccu                                                   20


<210> 37
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
aguccucccg cuucacaga                                                    19


<210> 38
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
gcccacuucc aguuccuuuc c                                                 21


