                         SEQUENCE LISTING

<110>  The Johns Hopkins University
 
<120>  COMPOSITIONS AND METHODS FOR DETECTING AND TREATING TYPE 1 
       DIABETES AND OTHER AUTOIMMUNE DISEASES

<130>  P14290-03

<150>  62/854,289
<151>  2019-05-29

<150>  62/854,286
<151>  2019-05-29

<150>  62/782,646
<151>  2018-12-20

<150>  62/782,624
<151>  2018-12-20

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  1

Cys Ala Arg Gln Glu Asp Thr Ala Met Val Tyr Tyr Phe Asp Tyr Trp 
1               5                   10                  15      


<210>  2
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  2
tactgtgcga gacaggagga tacagctatg gtttactact ttgactactg gggccaggga       60


<210>  3
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Phe Trp Ser Gly Pro Leu 
1               5           


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  4

His Gly Asn Glu Val Gly Thr Met Trp Leu 
1               5                   10  


<210>  5
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Asn Glu Lys Arg Trp Ile His Phe Asp Phe 
1               5                   10      


<210>  6
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Leu Gly Ile Pro 
1               5   


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser His Leu Val Glu Glu Leu Tyr Leu Val Ala Gly Glu Glu Gly 
1               5                   10                  15  


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Val Tyr Met Gln Ala Ala Thr Met Leu Trp Tyr Ser 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  9

Cys Ser Leu Tyr Ala Gly Ser Asn Asn Val Val Val Phe 
1               5                   10              


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  10

Cys Ala Ser Ser Ala Ser Gly Gly Gly Gly Ser Asn Tyr Lys Leu Thr 
1               5                   10                  15      


Phe 
    


<210>  11
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Ala Ser Ser Tyr Pro Gly Thr Ala Glu Ala Phe Phe 
1               5                   10              


<210>  12
<211>  334
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(334)
<223>  nucleotide sequence encoding IgL1 (light chain 1) of x-mAb

<400>  12
cagtctgtgc tgacgcagcc tccctccgcg tccgggtctt ttggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacattggt acttataatt atgtctcctg gtaccaacag      120

cacccaggca gggcccccaa actcatgatt tctgacatca ataagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctggactc      240

caggctgatg atgaggctga ttattattgt agtctatatg caggcagcaa caatgttgtg      300

gtattcggcg gagggaccaa gctgaccgtc ctag                                  334


<210>  13
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(333)
<223>  nucleotide sequence encoding IgL2 (light chain 2) of x-mAb

<400>  13
aattttatgc tgactcagcc tccctccgcg tccgggtctt ttggacagtc agtcaccatc       60

tcctgcactg gaaccaacag tgacattggt acttataatt atgtctcctg gtaccaacag      120

cacccaggca aggcccccaa actcatgatt tctgacatca ataagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgactcc      240

aggctgatga tgaggctgat tattattgta gtctatatgc aggcagcaac aatgttgtgg      300

tattcggcgg agggaccaag ctgaccgtcc tag                                   333


<210>  14
<211>  349
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(349)
<223>  nucleotide sequence encoding TCR-alpha

<400>  14
ctcactatag ggcgaattgg gcccgacgtc gcatgctccc ggccgccatg gcggccgcgg       60

gaattcgatt gaaacaagaa tagaaggaga tattgtatcc tatggtacaa aaaataccct      120

gctgaaggtc ctacattcct gatatctata agttccatta aggataaaaa tgaagatgga      180

agattcactg ttttcttaaa caaaagtgcc aagcacctct ctctgcacat tgtgccctcc      240

cagcctggag actctgcagt gtacttctgt gcagcaagcg cgtcgggtgg tggaggtagc      300

aactataaac tgacatttgg aaaaggaact ctcttaaccg tgaatccaa                  349


<210>  15
<211>  337
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(337)
<223>  nucleotide sequence encoding TCR-beta

<400>  15
actatagggc gaattgggcc cgacgtcgca tgctcccggc cgccatggcg gccgcgggaa       60

ttcgattgaa acaagaatag aaggagatat tgtatgtcct ggtatcgaca agacccaggc      120

atggggctga ggctgattca ttactcagtt ggtgctggta tcactgacca aggagaagtc      180

cccaatggct acaatgtctc cagatcaacc acagaggatt tcccgctcag gctgctgtcg      240

gctgctccct cccagacatc tgtgtacttc tgtgccagca gttaccccgg gacggctgaa      300

gctttctttg gacaaggcac cagactcaca gttgtag                               337


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly 
1               5                   10                  15  


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  x-Id forward primer 1

<400>  17
gctggagtgg attgggagta                                                   20


<210>  18
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  x-Id reverse primer 1

<400>  18
cccagtagtc aaagtagtaa accata                                            26


<210>  19
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  x-Id reverse primer 2

<400>  19
tccctggccc cagtagtcaa agtagta                                           27


<210>  20
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Ala Gly Gly His Asn Tyr Gly Ile Lys Ser Tyr Trp 
1               5                   10              


<210>  21
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  21

Cys Ala Arg Gln Arg Phe Trp Ser Gly Pro Leu Phe Asp Tyr Trp 
1               5                   10                  15  


<210>  22
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Gln Glu Asn Phe Asp Thr Ala Met Val Tyr Tyr Phe 
1               5                   10              


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  x-Id forward primer 2

<400>  23
ctgcgctgtc tctggttac                                                    19


<210>  24
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  x-Id reverse primer 3

<400>  24
tccctggccc ccagtagtca aagtagta                                          28


<210>  25
<211>  48
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(48)
<223>  nucleotide sequence encoding CDR3 (x-Id clonotype)

<400>  25
tgtgcgagac aggaggatac agctatggtt tactactttg actactgg                    48


<210>  26
<211>  926
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleotide sequence encoding heavy chain of x-mAb (including 
       vector sequence)

<400>  26
tatgtatcat acacatacga tttaggtgac actatagaat aacatccact ttgcctttct       60

ctccacaggt gtccactccc aggtccaact gcacctcggt tctatcgatt gaattccacc      120

atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag      180

gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcacc      240

tgcgctgtct ctggctactc catcagcagt ggttactact ggggctggat ccggcagccc      300

ccagggaagg ggctggagtg gattgggagt atctatcata gtgggagcac ctactacaac      360

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      420

aagctgagct ctgtgaccgc cgcagacacg gccgtgtatt actgtgcgag acaggaggat      480

acagctatgg tttactactt tgactactgg ggccagggaa ccctggtcac cgtctcctca      540

gcgtcgacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      600

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaacctgt gacggtctcg      660

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      720

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      780

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      840

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      900

ccgtcagtct tcctcttccc cccaaa                                           926


<210>  27
<211>  364
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(364)
<223>  nucleotide sequence encoding heavy chain of x-mAb

<400>  27
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcgctg tctctggcta ctccatcagc agtggttact actggggctg gatccggcag      120

cccccaggga aggggctgga gtggattggg agtatctatc atagtgggag cacctactac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca cgtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgccgcagac acggccgtgt attactgtgc gagacaggag      300

gatacagcta tggtttacta ctttgactac tggggccagg gaaccctggt caccgtctcc      360

tcag                                                                   364


<210>  28
<211>  121
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(121)
<223>  amino acid sequence of heavy chain of x-mAb

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Glu Asp Thr Ala Met Val Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  29
<211>  581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding IgL1 (light chain 1) of x-mAb 
       (including vector sequence)

<400>  29
ttctctccac caggtgtccc actcccaggt ccaactgcac ctcggttcta tcgattgaat       60

tccaccatgg gatggtcatg tatcatcctt tttctagtag caactgcaac cggttccaat      120

tctcagactg tggtgaccca gttctcaggc tgtggcgttc ttgagccaat tttatgctgc      180

tctgtgacct ccctatgagc tgagtcagca cagactgggc ccaggaaccg gttcttgggc      240

caattttatg ctgactcagc ctccctccgc gtccgggtct tttggacagt cagtcaccat      300

ctcctgcact ggaaccagca gtgacattgg tacttataat tatgtctcct ggtaccaaca      360

gcacccaggc aaggccccca aactcatgat ttctgacatc aataagcggc tctcaggggt      420

ccctgatcgc ttctctggct ccaagtctgg caacacggcc tccctgaccg tctctggact      480

ccaggctgat gatgaggctg attattattg tagtctatat gcaggcagca acaatgttgt      540

ggtattcggc ggagggacca agctgaccgt cctagtcagc c                          581


<210>  30
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(111)
<223>  amino acid sequence of IgL1 (light chain 1) of x-mAb

<400>  30

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Phe Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Thr Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Arg Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Ser Asp Ile Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Leu Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  31
<211>  885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding IgL2 (light chain 2) of x-mAb 
       (including vector sequence)

<400>  31
caatttaacc ctttatgtat catacacata cgatttaggt gacactatag aataacatcc       60

actttgcctt tctctccaca ggtgtccact cccaggtcca actgcacctc ggttctatcg      120

attgaattcc accatgggat ggtcatgtat catccttttt ctagtagcaa ctgcaaccgg      180

ttcttgggcc aattttatgc tgactcagcc tccctccgcg tccgggtctt ttggacagtc      240

agtcaccatc tcctgcactg gaaccaacag tgacattggt acttataatt atgtctcctg      300

gtaccaacag cacccaggca aggcccccaa actcatgatt tctgacatca ataagcggcc      360

ctcaggggtc cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt      420

ctctgactcc aggctgatga tgaggctgat tattattgta gtctatatgc aggcagcaac      480

aatgttgtgg tattcggcgg agggaccaag ctgaccgtcc taggtcagcc cagggctgcc      540

ccctcggtca ctctgttccc gccctcgagt gaggagcttc aagccaacaa ggccacactg      600

gtgtgtctca taagtgactt ctacccggga gccgtgacag tggcctggaa ggcagatagc      660

agccccgtca aggcgggagt ggagaccacc acaccctccc aaacaaagca acaacaagta      720

cgcggccagc agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag      780

ctgccaggtc acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc      840

atagaagctt ggccgccatg gcccaaactt gtttattgca gcctt                      885


<210>  32
<211>  109
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(109)
<223>  amino acid sequence of IgL2 (light chain 2) of x-mAb

<400>  32

Asn Phe Met Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Phe Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Ile Gly Thr Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Ser Asp Ile Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Asp Ser 
65                  70                  75                  80  


Arg Leu Met Met Arg Leu Ile Ile Ile Val Val Tyr Met Gln Ala Ala 
                85                  90                  95      


Thr Met Leu Trp Tyr Ser Ala Glu Gly Pro Ser Pro Ser 
            100                 105                 


<210>  33
<211>  115
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(115)
<223>  amino acid sequence of TCR-alpha

<400>  33

Leu Thr Ile Gly Arg Ile Gly Pro Asp Val Ala Cys Ser Arg Pro Pro 
1               5                   10                  15      


Trp Arg Pro Arg Glu Phe Asp Asn Lys Asn Arg Arg Arg Tyr Cys Ile 
            20                  25                  30          


Leu Trp Tyr Lys Lys Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser 
        35                  40                  45              


Ile Ser Ser Ile Lys Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe 
    50                  55                  60                  


Leu Asn Lys Ser Ala Lys His Leu Ser Leu His Ile Val Pro Ser Gln 
65                  70                  75                  80  


Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser Ala Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu Leu Thr 
            100                 105                 110         


Val Asn Pro 
        115 


<210>  34
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(111)
<223>  amino acid sequence of TCR-beta

<400>  34

Thr Ile Gly Arg Ile Gly Pro Asp Val Ala Cys Ser Arg Pro Pro Trp 
1               5                   10                  15      


Arg Pro Arg Glu Phe Asp Asn Lys Asn Arg Arg Arg Tyr Cys Met Ser 
            20                  25                  30          


Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr Ser 
        35                  40                  45              


Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr Asn 
    50                  55                  60                  


Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser Ala 
65                  70                  75                  80  


Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Pro Gly 
                85                  90                  95      


Thr Ala Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val 
            100                 105                 110     


<210>  35
<211>  349
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(349)
<223>  nucleotide sequence encoding TCR-alpha

<400>  35
gaccagcaag ttaagcaaaa ttcaccatcc ctgagcgtcc aggaaggaag aatttctatt       60

ctgaactgtg actatactaa cagcatgttt gattatttcc tatggtacaa aaaataccct      120

gctgaaggtc ctacattcct gatatctata agttccatta aggataaaaa tgaagatgga      180

agattcactg tcttcttaaa caaaagtgcc aagcacctct ctctgcacat tgtgccctcc      240

cagcctggag actctgcagt gtacttctgt gcagcaagcg cgtcgggtgg tggaggtagc      300

aactataaac tgacatttgg aaaaggaact ctcttaaccg tgaatccaa                  349


<210>  36
<211>  244
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(244)
<223>  nucleotide sequence encoding TCR-beta

<400>  36
atgtcctggt atcgacaaga cccaggcatg gggctgaggc tgattcatta ctcagttggt       60

gctggtatca ctgaccaagg agaagtcccc aatggctaca atgtctccag atcaaccaca      120

gaggatttcc cgctcaggct gctgtcggct gctccctccc agacatctgt gtacttctgt      180

gccagcagtt acctcgggac ggctgaagct ttctttggac aaggcaccag actcacagtt      240

gtag                                                                   244


<210>  37
<211>  27
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  nucleotide sequence encoding IGL1 CDR1

<400>  37
agcagtgaca ttggtactta taattat                                           27


<210>  38
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  amino acid sequence of IGL1 CDR1

<400>  38

Ser Ser Asp Ile Gly Thr Tyr Asn Tyr 
1               5                   


<210>  39
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  nucleotide sequence encoding IGL1 CDR2

<400>  39
gacatcaat                                                                9


<210>  40
<211>  3
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  amino acid sequence of IGL1 CDR2

<400>  40

Asp Ile Asn 
1           


<210>  41
<211>  36
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  nucleotide sequence encoding IGL1 CDR3

<400>  41
tgtagtctat atgcaggcag caacaatgtt gtggta                                 36


<210>  42
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  amino acid sequence of IGL1 CDR3

<400>  42

Cys Ser Leu Tyr Ala Gly Ser Asn Asn Val Val Val 
1               5                   10          


<210>  43
<211>  26
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(26)
<223>  nucleotide sequence encoding IGH CDR1

<400>  43
ggctactcca tcagcagtgg ttacta                                            26


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  amino acid of IGH CDR1

<400>  44

Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr 
1               5                   


<210>  45
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  nucleotide sequence encoding IGH CDR2

<400>  45
atctatcata gtgggagcac c                                                 21


<210>  46
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  amino acid sequence of IGH CDR2

<400>  46

Ile Tyr His Ser Gly Ser Thr 
1               5           


<210>  47
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  nucleotide sequence encoding TCR-alpha CDR1

<400>  47
aacagcatgt ttgattat                                                     18


<210>  48
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  amino acid sequence of TCR-alpha CDR1

<400>  48

Asn Ser Met Phe Asp Tyr 
1               5       


<210>  49
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  nucleotide sequence of TCR-alpha CDR2

<400>  49
ataagttcca ttaaggataa a                                                 21


<210>  50
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  amino acid sequence of TCR-alpha CDR2

<400>  50

Ile Ser Ser Ile Lys Asp Lys 
1               5           


<210>  51
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(51)
<223>  nucleotide sequence encoding TCR-alpha CDR3

<400>  51
tgtgcagcaa gcgcgtcggg tggtggaggt agcaactata aactgacatt t                51


<210>  52
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  amino acid sequence of TCR-alpha CDR3

<400>  52

Cys Ala Ala Ser Ala Ser Gly Gly Gly Gly Ser Asn Tyr Lys Leu Thr 
1               5                   10                  15      


Phe 
    


<210>  53
<211>  15
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  nucleotide sequence encoding TCR-beta CDR1

<400>  53
atgaaccatg aatac                                                        15


<210>  54
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  amino acid sequence of TCR-beta CDR1

<400>  54

Met Asn His Glu Tyr 
1               5   


<210>  55
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  nucleotide sequence encoding TCR-beta CDR2

<400>  55
tcagttggtg ctggtatc                                                     18


<210>  56
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  amino acid sequence of TCR-beta CDR2

<400>  56

Ser Val Gly Ala Gly Ile 
1               5       


<210>  57
<211>  48
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(48)
<223>  nucleotide sequence encoding TCR-beta CDR3

<400>  57
gccagcagtt acctcgggac ggctgaagct ttctttggac aaggcacc                    48


<210>  58
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  amino acid sequence of TCR-beta CDR3

<400>  58

Cys Ala Ser Ser Tyr Leu Gly Thr Ala Glu Ala Phe Phe 
1               5                   10              


<210>  59
<211>  24
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  nucleotide sequence encoding IGH CDR1 of anti-idiotypic Ab

<400>  59
ggttacaggt ttaccagata tggg                                              24


<210>  60
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  amino acid sequence of IGH CDR1 of anti-idiotypic Ab

<400>  60

Gly Tyr Arg Phe Thr Arg Tyr Gly 
1               5               


<210>  61
<211>  24
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  nucleotide sequence encoding IGH CDR2 of anti-idiotypic Ab

<400>  61
atcagcgcat acagtggaga caca                                              24


<210>  62
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  amino acid sequence of IGH CDR2 of anti-idiotypic Ab

<400>  62

Ile Ser Ala Tyr Ser Gly Asp Thr 
1               5               


<210>  63
<211>  57
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(57)
<223>  nucleotide sequence encoding IGH CDR3 of anti-idiotypic Ab

<400>  63
tgtgcgagag atcacgtcca aggggaagtg agcatatatt attatgccat ggacgtc          57


<210>  64
<211>  19
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  amino acid sequence of IGH CDR3 of anti-idiotypic Ab

<400>  64

Cys Ala Arg Asp His Val Gln Gly Glu Val Ser Ile Tyr Tyr Tyr Ala 
1               5                   10                  15      


Met Asp Val 
            


<210>  65
<211>  27
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  nucleotide sequence encoding IGL CDR1 of anti-idiotypic Ab

<400>  65
agcagtgaca ttggtactta taattat                                           27


<210>  66
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  amino acid sequence of IGL CDR1 of anti-idiotypic Ab

<400>  66

Ser Ser Asp Ile Gly Thr Tyr Asn Tyr 
1               5                   


<210>  67
<211>  9
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  nucleotide sequence encoding IGL CDR2 of anti-idiotypic Ab

<400>  67
gacatcaat                                                                9


<210>  68
<211>  3
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  amino acid sequence of IGL CDR2 of anti-idiotypic Ab

<400>  68

Asp Ile Asn 
1           


<210>  69
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(33)
<223>  nucleotide sequence encoding IGL CDR3 of anti-idiotypic Ab

<400>  69
agtctatatg caggcagcaa caatgttgtg gta                                    33


<210>  70
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  amino acid sequence of IGL CDR3 of anti-idiotypic Ab

<400>  70

Ser Leu Tyr Ala Gly Ser Asn Asn Val Val Val 
1               5                   10      


<210>  71
<211>  36
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  nucleotide sequence of IGL CDR3 of anti-idiotypic Ab

<400>  71
tgtagtctat atgcaggcag caacaatgtt gtggta                                 36


<210>  72
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  amino acid sequence of IGL CDR3 of anti-idiotypic Ab

<400>  72

Cys Ser Leu Tyr Ala Gly Ser Asn Asn Val Val Val 
1               5                   10          


<210>  73
<211>  376
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(376)
<223>  nucleotide sequence encoding IGH of anti-idiotypic Ab

<400>  73
gaggtgcagc tggtgcagtc tggacctgag atgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaaga cttctggtta caggtttacc agatatggga tcagttgggt gcggcaggcc      120

cctggacggg ggctggagtg gctggggtgg atcagcgcat acagtggaga cacatattat      180

ggacagaaat tccaggacag agtcaccatg actacagaca gagccacgag tacagcctat      240

atggagttgc ggaacctggg atctgacgac tcggccgttt atttctgtgc gagagatcac      300

gtccaagggg aagtgagcat atattattat gccatggacg tctggggcga agggaccacg      360

gtcaccgtct cctcag                                                      376


<210>  74
<211>  125
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(125)
<223>  amino acid sequence of IGH of anti-idiotypic Ab

<400>  74

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Arg Phe Thr Arg Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Ser Gly Asp Thr Tyr Tyr Gly Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Thr Asp Arg Ala Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Gly Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp His Val Gln Gly Glu Val Ser Ile Tyr Tyr Tyr Ala Met 
            100                 105                 110         


Asp Val Trp Gly Glu Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  75
<211>  334
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(334)
<223>  nucleotide sequence encoding IGL of anti-idiotypic Ab

<400>  75
cagcttgtgc tgactcagcc tccctccgcg tccgggtctt ttggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacattggt acttataatt atatctcctg gtaccaacag      120

cacccaggca aggcccccaa actcatgatt tctgacatca ataagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctggactc      240

caggctgatg atgaggctga ttattattgt agtctatatg caggcagcaa caatgttgtg      300

gtattcggcg gagggaccaa gctgaccgtc ctag                                  334


<210>  76
<211>  111
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(111)
<223>  amino acid sequence of IGL of anti-idiotypic Ab

<400>  76

Gln Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Phe Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Thr Tyr 
            20                  25                  30          


Asn Tyr Ile Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Ser Asp Ile Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Leu Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  77
<211>  24
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  nucleotide sequence encoding IGH CDR1 of anti-idiotypic Ab

<400>  77
ggattcagcg tcagtgacaa ctac                                              24


<210>  78
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  amino acid sequence of IGH CDR1 of anti-idiotypic Ab

<400>  78

Gly Phe Ser Val Ser Asp Asn Tyr 
1               5               


<210>  79
<211>  21
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  nucleotide sequence encoding IGH CDR2 of anti-idiotypic Ab

<400>  79
atttatagcg gtggtagcac a                                                 21


<210>  80
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  amino acid sequence of IGH CDR2 of anti-idiotypic Ab

<400>  80

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  81
<211>  39
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(39)
<223>  nucleotide sequence encoding IGH CDR3 of anti-idiotypic Ab

<400>  81
tgtgcgggtg gacacaacta tggtataaag tcctactgg                              39


<210>  82
<211>  13
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  amino acid sequence of IGH CDR3 of anti-idiotypic Ab

<400>  82

Cys Ala Gly Gly His Asn Tyr Gly Ile Lys Ser Tyr Trp 
1               5                   10              


<210>  83
<211>  18
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  nucleotide sequence encoding IGL CDR1 of anti-idiotypic Ab

<400>  83
cacgatatta acgacaac                                                     18


<210>  84
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  amino acid sequence encoding IGL CDR1 of anti-idiotypic Ab

<400>  84

His Asp Ile Asn Asp Asn 
1               5       


<210>  85
<211>  9
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  nucleotide sequence encoding IGL CDR2 of anti-idiotypic Ab

<400>  85
ggtgcatcc                                                                9


<210>  86
<211>  3
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  amino acid sequence encoding IGL CDR2 of anti-idiotypic Ab

<400>  86

Gly Ala Ser 
1           


<210>  87
<211>  36
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  nucleotide sequence encoding IGL CDR3 of anti-idiotypic Ab

<400>  87
tgtcagcagt attataggtg gcctccgctc actttc                                 36


<210>  88
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  amino acid sequence encoding IGL CDR3 of anti-idiotypic Ab

<400>  88

Cys Gln Gln Tyr Tyr Arg Trp Pro Pro Leu Thr Phe 
1               5                   10          


<210>  89
<211>  352
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(352)
<223>  nucleotide sequence encoding IGH of anti-idiotypic Ab

<400>  89
gaggtgcagc tgcaggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagcgtcagt aacaactaca tgagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtttctt      240

caagtcaaca gcctgggagc tgaggacacg gctgtctatt actgtgcggg tggacacaac      300

tatggtataa agtcctactg gggccaggga accctggtca ccgtctcctc ag              352


<210>  90
<211>  117
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(117)
<223>  amino acid sequence of IGH of anti-idiotypic Ab

<400>  90

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Asn Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Val Asn Ser Leu Gly Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Gly His Asn Tyr Gly Ile Lys Ser Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  91
<211>  325
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(325)
<223>  nucleotide sequence encoding IGL of anti-idiotypic Ab

<400>  91
gaaatagtga tgacgcagtc tccagccacc ctatctttgt ctccaggtga aacggccacc       60

ctctcctgca gggccagtca cgatattaac gacaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcgt catctatggt gcatccacca gggtcactgc tttcccagcc      180

aggttcactg gcagtgggac tgggacagag ttcactctca ccatcagtag cctgcagtct      240

gaagatcttg cagtttatta ctgtcagcag tattataggt ggcctccgct cactttcggc      300

ggagggacca aggtggaaat caaac                                            325


<210>  92
<211>  108
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  amino acid sequence of IGL of anti-idiotypic Ab

<400>  92

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser His Asp Ile Asn Asp Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Val Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Val Thr Ala Phe Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Thr Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Arg Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


