                         SEQUENCE LISTING

<110>  ULTRAGENYX PHARMACEUTICAL INC.
 
<120>  METHODS AND COMPOSITIONS FOR TREATING GLYCOGEN STORAGE DISEASES

<130>  DIM-010WO

<150>  62/781,380
<151>  2018-12-18

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  3882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: DTC177: ITR to ITR

<400>  1
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctccttt gagaatccac ggtgtctcga tgcagtcagc      180

tttctaacaa gctggggcct cacctgtttt cccacggata aaaacgtgct ggaggaagca      240

gaaaggggct ggcaggtgga aagatgagga ccagctcatc gtctcatgac tatgaggttg      300

ctctgatcca gagggtcccc ctgcctggtg gcccaccgcc aggaagactc ccactgtccc      360

tggatgccca gagtgggatg tcaactccat cacttatcaa ctccttatcc ataggggtat      420

tcttcctgag gcgtctcaga aaacagggcc ctccccatat gctgaccaca taatagaacc      480

cctcccaact cagagaccct ggctgctagc tgccctggca tgacccagac agtggccttt      540

gtatatgttt ttagactcac cttgactcac ctctgaccat agaaactctc atcccagagg      600

tcactgcaat agttactcca caacagaggc ttatctgggt agagggaggc tccctaccta      660

tggcccagca gccctgacag tgcagatcac atatacccca cgccccagca ctgcctgcca      720

cgcatgggct tactttacac ccacccacag tcaccaacac attacctgct ctccaaggtt      780

aggcgtggca ggagaagttt gcttggacca gcagaaacca tgcagtcaag gacaactgga      840

gtcagcatgg gctgggtgcg agcccttggt ggggtgggga ggagactcca ggtcatacct      900

cctggaggat gttttaatca tttccagcat ggaatgctgt caacttttgc cacagattca      960

ttagctctga gtttcttttt tctgtcccca gctacccctt acatgtcaat atggacttaa     1020

tgatgggaaa ttcaggcaag tttttaaaca ttttattccc cctggctctt atcctcaaaa     1080

aatgcatgag ttcgttacct gattcattcc ctggttcctt tcacagtcct ccgtgaccca     1140

agtgttaggg ttttggtctc tctactattt gtaggctgat atatagtata cacacacaca     1200

cacacacaca tatacacaca cacagtgtat cttgagcttt cttttgtata tctacacaca     1260

tatgtataag aaagctcaag atatagaagc cctttttcaa aaataactga aagtttcaaa     1320

ctctttaagt ctccagttac cattttgctg gtattcttat ttggaaccat acattcatca     1380

tattgttgca cagtaagact atacattcat tattttgctt aaacgtatga gttaaaacac     1440

tttaaggtca ttaaatgaat taatcactgc attcaaaaac gattactttc tggccctaag     1500

agacatgagg ccaataccag gaagggggtt gatctcccaa accagaggca gaccctagac     1560

tctaatacag ttaaggaaag accagcaaga tgatagtccc caatacaata gaactttact     1620

aattttaaaa ttaagaactt aaaacttgaa tagctagagc accaagattt ttctttgtcc     1680

ccaaataagt gcagttgcag gcatagaaaa tctgacatct ttgcaagaat catcgtggat     1740

gtagactctg tcctgtgtct ctggcctggt ttcggggacc aggagggcag acccttgcac     1800

tgccaagaag catgccaaag ttaatcattg gccctgctga gtacatggcc gatcaggctg     1860

tttttgtgtg cctgtttttc tattttacgt aaatcaccct gaacatgttt gcatcaacct     1920

actggtgatg cacctttgat caatacattt tagacaaacg tggtttttga gtccaaagat     1980

cagggctggg ttgacctgaa tactggatac agggcatata aaacaggggc aaggcacaga     2040

ctcatagcag agcaatcacc accaagcctg gaataactgc aagggctctg ctgacatctt     2100

cctgaggtgc caaggaaatg aggtctagag aagctttatt gcggtagttt atcacagtta     2160

aattgctaac gcagtcagtg cttctgacac aacagtctcg aacttaagct gcagtgactc     2220

tcttaaggta gccttgcaga agttggtcgt gaggcactgg gcaggtaagt atcaaggtta     2280

caagacaggt ttaaggagac caatagaaac tgggcttgtc gagacagaga agactcttgc     2340

gtttctgata ggcacctatt ggtcttactg acatccactt tgcctttctc tccacaggtg     2400

tccactccca gttcaattac agctcttaag gccctgcagg ccaccatgga agagggcatg     2460

aacgtgctgc acgacttcgg catccagagc acccactatc tgcaggtcaa ctaccaggac     2520

agccaggact ggttcatcct ggtgtccgtg atcgccgacc tgcggaacgc cttctacgtg     2580

ctgttcccca tctggttcca tctgcaagaa gccgtcggca tcaagctgct gtgggtggcc     2640

gtgatcggcg attggctgaa cctggtgttc aagtggatcc tgttcggcca gcggccctat     2700

tggtgggtgc tggacaccga ctactacagc aacaccagcg tgcccctgat caagcagttc     2760

cccgtgacct gcgagacagg ccctggctct ccttctggcc acgccatggg aacagccggc     2820

gtgtactacg tgatggtcac cagcaccctg agcatcttcc agggcaagat caagcccacc     2880

taccggttcc ggtgcctgaa cgtgatcctg tggctgggct tctgggccgt gcagctgaac     2940

gtgtgcctga gccggatcta cctggccgcc cacttcccac atcaagtggt ggccggcgtg     3000

ctgagcggaa tcgccgtggc cgagacattc agccacatcc acagcatcta caacgccagc     3060

ctgaagaagt acttcctgat cacattcttt ctgttcagct tcgccatcgg cttctacctg     3120

ctgctgaagg gcctgggcgt ggacctgctg tggaccctgg aaaaggccca gcggtggtgc     3180

gagcagcccg agtgggtgca catcgacacc acccccttcg ccagcctgct gaagaacctg     3240

ggcaccctgt ttggactggg cctggccctg aacagcagca tgtacagaga gagctgcaag     3300

ggcaagctga gcaagtggct gcccttccgg ctgagcagca tcgtggccag cctggtgctg     3360

ctgcacgtgt tcgacagcct gaagcccccc agccaggtgg aactggtgtt ttacgtgctg     3420

agcttctgca agagcgccgt ggtgcccctg gcctccgtgt ctgtgatccc ctactgcctg     3480

gctcaggtgc tgggccagcc ccacaagaag tccctctgag cgctctaggc ggccgcgcgg     3540

atccagacat gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa     3600

aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct     3660

gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg     3720

tgtgggaggt tttttagagg aacccctagt gatggagttg gccactccct ctctgcgcgc     3780

tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt cgggcgacct ttggtcgccc     3840

ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc aa                        3882


<210>  2
<211>  3882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of artificial sequence: DTC177wt: Replacement of 
       coG6PC sequence with wildtype coding sequence

<400>  2
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctccttt gagaatccac ggtgtctcga tgcagtcagc      180

tttctaacaa gctggggcct cacctgtttt cccacggata aaaacgtgct ggaggaagca      240

gaaaggggct ggcaggtgga aagatgagga ccagctcatc gtctcatgac tatgaggttg      300

ctctgatcca gagggtcccc ctgcctggtg gcccaccgcc aggaagactc ccactgtccc      360

tggatgccca gagtgggatg tcaactccat cacttatcaa ctccttatcc ataggggtat      420

tcttcctgag gcgtctcaga aaacagggcc ctccccatat gctgaccaca taatagaacc      480

cctcccaact cagagaccct ggctgctagc tgccctggca tgacccagac agtggccttt      540

gtatatgttt ttagactcac cttgactcac ctctgaccat agaaactctc atcccagagg      600

tcactgcaat agttactcca caacagaggc ttatctgggt agagggaggc tccctaccta      660

tggcccagca gccctgacag tgcagatcac atatacccca cgccccagca ctgcctgcca      720

cgcatgggct tactttacac ccacccacag tcaccaacac attacctgct ctccaaggtt      780

aggcgtggca ggagaagttt gcttggacca gcagaaacca tgcagtcaag gacaactgga      840

gtcagcatgg gctgggtgcg agcccttggt ggggtgggga ggagactcca ggtcatacct      900

cctggaggat gttttaatca tttccagcat ggaatgctgt caacttttgc cacagattca      960

ttagctctga gtttcttttt tctgtcccca gctacccctt acatgtcaat atggacttaa     1020

tgatgggaaa ttcaggcaag tttttaaaca ttttattccc cctggctctt atcctcaaaa     1080

aatgcatgag ttcgttacct gattcattcc ctggttcctt tcacagtcct ccgtgaccca     1140

agtgttaggg ttttggtctc tctactattt gtaggctgat atatagtata cacacacaca     1200

cacacacaca tatacacaca cacagtgtat cttgagcttt cttttgtata tctacacaca     1260

tatgtataag aaagctcaag atatagaagc cctttttcaa aaataactga aagtttcaaa     1320

ctctttaagt ctccagttac cattttgctg gtattcttat ttggaaccat acattcatca     1380

tattgttgca cagtaagact atacattcat tattttgctt aaacgtatga gttaaaacac     1440

tttaaggtca ttaaatgaat taatcactgc attcaaaaac gattactttc tggccctaag     1500

agacatgagg ccaataccag gaagggggtt gatctcccaa accagaggca gaccctagac     1560

tctaatacag ttaaggaaag accagcaaga tgatagtccc caatacaata gaactttact     1620

aattttaaaa ttaagaactt aaaacttgaa tagctagagc accaagattt ttctttgtcc     1680

ccaaataagt gcagttgcag gcatagaaaa tctgacatct ttgcaagaat catcgtggat     1740

gtagactctg tcctgtgtct ctggcctggt ttcggggacc aggagggcag acccttgcac     1800

tgccaagaag catgccaaag ttaatcattg gccctgctga gtacatggcc gatcaggctg     1860

tttttgtgtg cctgtttttc tattttacgt aaatcaccct gaacatgttt gcatcaacct     1920

actggtgatg cacctttgat caatacattt tagacaaacg tggtttttga gtccaaagat     1980

cagggctggg ttgacctgaa tactggatac agggcatata aaacaggggc aaggcacaga     2040

ctcatagcag agcaatcacc accaagcctg gaataactgc aagggctctg ctgacatctt     2100

cctgaggtgc caaggaaatg aggtctagag aagctttatt gcggtagttt atcacagtta     2160

aattgctaac gcagtcagtg cttctgacac aacagtctcg aacttaagct gcagtgactc     2220

tcttaaggta gccttgcaga agttggtcgt gaggcactgg gcaggtaagt atcaaggtta     2280

caagacaggt ttaaggagac caatagaaac tgggcttgtc gagacagaga agactcttgc     2340

gtttctgata ggcacctatt ggtcttactg acatccactt tgcctttctc tccacaggtg     2400

tccactccca gttcaattac agctcttaag gccctgcagg ccaccatgga ggaaggaatg     2460

aatgttctcc atgactttgg gatccagtca acacattacc tccaggtgaa ttaccaagac     2520

tcccaggact ggttcatctt ggtgtccgtg atcgcagacc tcaggaatgc cttctacgtc     2580

ctcttcccca tctggttcca tcttcaggaa gctgtgggca ttaaactcct ttgggtagct     2640

gtgattggag actggctcaa cctcgtcttt aagtggattc tctttggaca gcgtccatac     2700

tggtgggttt tggatactga ctactacagc aacacttccg tgcccctgat aaagcagttc     2760

cctgtaacct gtgagactgg accagggagc ccctctggcc atgccatggg cacagcaggt     2820

gtatactacg tgatggtcac atctactctt tccatctttc agggaaagat aaagccgacc     2880

tacagatttc ggtgcttgaa tgtcattttg tggttgggat tctgggctgt gcagctgaat     2940

gtctgtctgt cacgaatcta ccttgctgct cattttcctc atcaagttgt tgctggagtc     3000

ctgtcaggca ttgctgttgc agaaactttc agccacatcc acagcatcta taatgccagc     3060

ctcaagaaat attttctcat taccttcttc ctgttcagct tcgccatcgg attttatctg     3120

ctgctcaagg gactgggtgt agacctcctg tggactctgg agaaagccca gaggtggtgc     3180

gagcagccag aatgggtcca cattgacacc acaccctttg ccagcctcct caagaacctg     3240

ggcacgctct ttggcctggg gctggctctc aactccagca tgtacaggga gagctgcaag     3300

gggaaactca gcaagtggct cccattccgc ctcagctcta ttgtagcctc cctcgtcctc     3360

ctgcacgtct ttgactcctt gaaaccccca tcccaagtcg agctggtctt ctacgtcttg     3420

tccttctgca agagtgcggt agtgcccctg gcatccgtca gtgtcatccc ctactgcctc     3480

gcccaggtcc tgggccagcc gcacaagaag tcgttgtaag cgctctaggc ggccgcgcgg     3540

atccagacat gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa     3600

aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct     3660

gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg     3720

tgtgggaggt tttttagagg aacccctagt gatggagttg gccactccct ctctgcgcgc     3780

tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt cgggcgacct ttggtcgccc     3840

ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc aa                        3882


<210>  3
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Codon-optimized G6PC coding 
       sequence

<400>  3
atggaagagg gcatgaacgt gctgcacgac ttcggcatcc agagcaccca ctatctgcag       60

gtcaactacc aggacagcca ggactggttc atcctggtgt ccgtgatcgc cgacctgcgg      120

aacgccttct acgtgctgtt ccccatctgg ttccatctgc aagaagccgt cggcatcaag      180

ctgctgtggg tggccgtgat cggcgattgg ctgaacctgg tgttcaagtg gatcctgttc      240

ggccagcggc cctattggtg ggtgctggac accgactact acagcaacac cagcgtgccc      300

ctgatcaagc agttccccgt gacctgcgag acaggccctg gctctccttc tggccacgcc      360

atgggaacag ccggcgtgta ctacgtgatg gtcaccagca ccctgagcat cttccagggc      420

aagatcaagc ccacctaccg gttccggtgc ctgaacgtga tcctgtggct gggcttctgg      480

gccgtgcagc tgaacgtgtg cctgagccgg atctacctgg ccgcccactt cccacatcaa      540

gtggtggccg gcgtgctgag cggaatcgcc gtggccgaga cattcagcca catccacagc      600

atctacaacg ccagcctgaa gaagtacttc ctgatcacat tctttctgtt cagcttcgcc      660

atcggcttct acctgctgct gaagggcctg ggcgtggacc tgctgtggac cctggaaaag      720

gcccagcggt ggtgcgagca gcccgagtgg gtgcacatcg acaccacccc cttcgccagc      780

ctgctgaaga acctgggcac cctgtttgga ctgggcctgg ccctgaacag cagcatgtac      840

agagagagct gcaagggcaa gctgagcaag tggctgccct tccggctgag cagcatcgtg      900

gccagcctgg tgctgctgca cgtgttcgac agcctgaagc cccccagcca ggtggaactg      960

gtgttttacg tgctgagctt ctgcaagagc gccgtggtgc ccctggcctc cgtgtctgtg     1020

atcccctact gcctggctca ggtgctgggc cagccccaca agaagtccct ctga           1074


<210>  4
<211>  1074
<212>  DNA
<213>  Homo sapiens

<400>  4
atggaggaag gaatgaatgt tctccatgac tttgggatcc agtcaacaca ttacctccag       60

gtgaattacc aagactccca ggactggttc atcttggtgt ccgtgatcgc agacctcagg      120

aatgccttct acgtcctctt ccccatctgg ttccatcttc aggaagctgt gggcattaaa      180

ctcctttggg tagctgtgat tggagactgg ctcaacctcg tctttaagtg gattctcttt      240

ggacagcgtc catactggtg ggttttggat actgactact acagcaacac ttccgtgccc      300

ctgataaagc agttccctgt aacctgtgag actggaccag ggagcccctc tggccatgcc      360

atgggcacag caggtgtata ctacgtgatg gtcacatcta ctctttccat ctttcaggga      420

aagataaagc cgacctacag atttcggtgc ttgaatgtca ttttgtggtt gggattctgg      480

gctgtgcagc tgaatgtctg tctgtcacga atctaccttg ctgctcattt tcctcatcaa      540

gttgttgctg gagtcctgtc aggcattgct gttgcagaaa ctttcagcca catccacagc      600

atctataatg ccagcctcaa gaaatatttt ctcattacct tcttcctgtt cagcttcgcc      660

atcggatttt atctgctgct caagggactg ggtgtagacc tcctgtggac tctggagaaa      720

gcccagaggt ggtgcgagca gccagaatgg gtccacattg acaccacacc ctttgccagc      780

ctcctcaaga acctgggcac gctctttggc ctggggctgg ctctcaactc cagcatgtac      840

agggagagct gcaaggggaa actcagcaag tggctcccat tccgcctcag ctctattgta      900

gcctccctcg tcctcctgca cgtctttgac tccttgaaac ccccatccca agtcgagctg      960

gtcttctacg tcttgtcctt ctgcaagagt gcggtagtgc ccctggcatc cgtcagtgtc     1020

atcccctact gcctcgccca ggtcctgggc cagccgcaca agaagtcgtt gtaa           1074


<210>  5
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Glu Gly Met Asn Val Leu His Asp Phe Gly Ile Gln Ser Thr 
1               5                   10                  15      


His Tyr Leu Gln Val Asn Tyr Gln Asp Ser Gln Asp Trp Phe Ile Leu 
            20                  25                  30          


Val Ser Val Ile Ala Asp Leu Arg Asn Ala Phe Tyr Val Leu Phe Pro 
        35                  40                  45              


Ile Trp Phe His Leu Gln Glu Ala Val Gly Ile Lys Leu Leu Trp Val 
    50                  55                  60                  


Ala Val Ile Gly Asp Trp Leu Asn Leu Val Phe Lys Trp Ile Leu Phe 
65                  70                  75                  80  


Gly Gln Arg Pro Tyr Trp Trp Val Leu Asp Thr Asp Tyr Tyr Ser Asn 
                85                  90                  95      


Thr Ser Val Pro Leu Ile Lys Gln Phe Pro Val Thr Cys Glu Thr Gly 
            100                 105                 110         


Pro Gly Ser Pro Ser Gly His Ala Met Gly Thr Ala Gly Val Tyr Tyr 
        115                 120                 125             


Val Met Val Thr Ser Thr Leu Ser Ile Phe Gln Gly Lys Ile Lys Pro 
    130                 135                 140                 


Thr Tyr Arg Phe Arg Cys Leu Asn Val Ile Leu Trp Leu Gly Phe Trp 
145                 150                 155                 160 


Ala Val Gln Leu Asn Val Cys Leu Ser Arg Ile Tyr Leu Ala Ala His 
                165                 170                 175     


Phe Pro His Gln Val Val Ala Gly Val Leu Ser Gly Ile Ala Val Ala 
            180                 185                 190         


Glu Thr Phe Ser His Ile His Ser Ile Tyr Asn Ala Ser Leu Lys Lys 
        195                 200                 205             


Tyr Phe Leu Ile Thr Phe Phe Leu Phe Ser Phe Ala Ile Gly Phe Tyr 
    210                 215                 220                 


Leu Leu Leu Lys Gly Leu Gly Val Asp Leu Leu Trp Thr Leu Glu Lys 
225                 230                 235                 240 


Ala Gln Arg Trp Cys Glu Gln Pro Glu Trp Val His Ile Asp Thr Thr 
                245                 250                 255     


Pro Phe Ala Ser Leu Leu Lys Asn Leu Gly Thr Leu Phe Gly Leu Gly 
            260                 265                 270         


Leu Ala Leu Asn Ser Ser Met Tyr Arg Glu Ser Cys Lys Gly Lys Leu 
        275                 280                 285             


Ser Lys Trp Leu Pro Phe Arg Leu Ser Ser Ile Val Ala Ser Leu Val 
    290                 295                 300                 


Leu Leu His Val Phe Asp Ser Leu Lys Pro Pro Ser Gln Val Glu Leu 
305                 310                 315                 320 


Val Phe Tyr Val Leu Ser Phe Cys Lys Ser Ala Val Val Pro Leu Ala 
                325                 330                 335     


Ser Val Ser Val Ile Pro Tyr Cys Leu Ala Gln Val Leu Gly Gln Pro 
            340                 345                 350         


His Lys Lys Ser Leu 
        355         


<210>  6
<211>  2864
<212>  DNA
<213>  Homo sapiens

<400>  6
cctttgagaa tccacggtgt ctcgatgcag tcagctttct aacaagctgg ggcctcacct       60

gttttcccac ggataaaaac gtgctggagg aagcagaaag gggctggcag gtggaaagat      120

gaggaccagc tcatcgtctc atgactatga ggttgctctg atccagaggg tccccctgcc      180

tggtggccca ccgccaggaa gactcccact gtccctggat gcccagagtg ggatgtcaac      240

tccatcactt atcaactcct tatccatagg ggtattcttc ctgaggcgtc tcagaaaaca      300

gggccctccc catatgctga ccacataata gaacccctcc caactcagag accctggctg      360

ctagctgccc tggcatgacc cagacagtgg cctttgtata tgtttttaga ctcaccttga      420

ctcacctctg accatagaaa ctctcatccc agaggtcact gcaatagtta ctccacaaca      480

gaggcttatc tgggtagagg gaggctccct acctatggcc cagcagccct gacagtgcag      540

atcacatata ccccacgccc cagcactgcc tgccacgcat gggcttactt tacacccacc      600

cacagtcacc aacacattac ctgctctcca aggttaggcg tggcaggaga agtttgcttg      660

gaccagcaga aaccatgcag tcaaggacaa ctggagtcag catgggctgg gtgcgagccc      720

ttggtggggt ggggaggaga ctccaggtca tacctcctgg aggatgtttt aatcatttcc      780

agcatggaat gctgtcaact tttgccacag attcattagc tctgagtttc ttttttctgt      840

ccccagctac cccttacatg tcaatatgga cttaatgatg ggaaattcag gcaagttttt      900

aaacatttta ttccccctgg ctcttatcct caaaaaatgc atgaatttgg aggcagtggc      960

tcatgcctgt aatcccaatg ctttgctagg ttgaggcggg aggatcactt gaagccagga     1020

atttgagacc agcctgggcc gcatagtgag accccgtttc tacaaaaata aataaataaa     1080

taataaataa tagtgatatg aagcatgatt aaatagccct attttttaaa atgcatgagt     1140

tcgttacctg attcattccc tggttccttt cacagtcctc cgtgacccaa gtgttagggt     1200

tttggtctct ctactatttg taggctgata tatagtatac acacacacac acacacacat     1260

atacacacac acagtgtatc ttgagctttc ttttgtatat ctacacacat atgtataaga     1320

aagctcaaga tatagaagcc ctttttcaaa aataactgaa agtttcaaac tctttaagtc     1380

tccagttacc attttgctgg tattcttatt tggaaccata cattcatcat attgttgcac     1440

agtaagacta tacattcatt attttgctta aacgtatgag ttaaaacact tggccaggca     1500

tggtggttca cacctgtaat cccagagctt tgggaagcca agactggcag atctcttgag     1560

ctcaggaatt caagaccagc ctgggcaaca tggaaaaacc ccatctctac aaaagataga     1620

aaaattagcc aggcatggtg gcgtgtgcct gtggtcccag ctactcagga ggctgaggtg     1680

ggaggatcac attagcccag gaggttgagg ctgcagtgag ccgtgattat gccactgcac     1740

tccagcctgg gagacagagt gagaccctgt ttcaaaaaaa agagagagaa aatttaaaaa     1800

agaaaacaac accaagggct gtaactttaa ggtcattaaa tgaattaatc actgcattca     1860

aaaacgatta ctttctggcc ctaagagaca tgaggccaat accaggaagg gggttgatct     1920

cccaaaccag aggcagaccc tagactctaa tacagttaag gaaagaccag caagatgata     1980

gtccccaata caatagaagt tactatattt tatttgttgt ttttcttttg ttttgttttg     2040

ttttgttttg ttttgtttta gagactgggg tcttgctcga ttgcccaggc tgtagtgcag     2100

cggtgggaca atagctcact gcagactcca actcctgggc tcaagcaatc ctcctgcctc     2160

agcctcctga atagctggga ctacaagggt acaccatcac acacaccaaa acaatttttt     2220

aaatttttgt gtagaaacga gggtcttgct ttgttgccca ggctggtctc caactcctgg     2280

cttcaaggga tcctcccacc tcagcctccc aaattgctgg gattacaggt gtgagccacc     2340

acaaccagcc agaactttac taattttaaa attaagaact taaaacttga atagctagag     2400

caccaagatt tttctttgtc cccaaataag tgcagttgca ggcatagaaa atctgacatc     2460

tttgcaagaa tcatcgtgga tgtagactct gtcctgtgtc tctggcctgg tttcggggac     2520

caggagggca gacccttgca ctgccaagaa gcatgccaaa gttaatcatt ggccctgctg     2580

agtacatggc cgatcaggct gtttttgtgt gcctgttttt ctattttacg taaatcaccc     2640

tgaacatgtt tgcatcaacc tactggtgat gcacctttga tcaatacatt ttagacaaac     2700

gtggtttttg agtccaaaga tcagggctgg gttgacctga atactggata cagggcatat     2760

aaaacagggg caaggcacag actcatagca gagcaatcac caccaagcct ggaataactg     2820

caagggctct gctgacatct tcctgaggtg ccaaggaaat gagg                      2864


<210>  7
<211>  2670
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: wildtype GPE but lacking Alu 
       - 1

<400>  7
cctttgagaa tccacggtgt ctcgatgcag tcagctttct aacaagctgg ggcctcacct       60

gttttcccac ggataaaaac gtgctggagg aagcagaaag gggctggcag gtggaaagat      120

gaggaccagc tcatcgtctc atgactatga ggttgctctg atccagaggg tccccctgcc      180

tggtggccca ccgccaggaa gactcccact gtccctggat gcccagagtg ggatgtcaac      240

tccatcactt atcaactcct tatccatagg ggtattcttc ctgaggcgtc tcagaaaaca      300

gggccctccc catatgctga ccacataata gaacccctcc caactcagag accctggctg      360

ctagctgccc tggcatgacc cagacagtgg cctttgtata tgtttttaga ctcaccttga      420

ctcacctctg accatagaaa ctctcatccc agaggtcact gcaatagtta ctccacaaca      480

gaggcttatc tgggtagagg gaggctccct acctatggcc cagcagccct gacagtgcag      540

atcacatata ccccacgccc cagcactgcc tgccacgcat gggcttactt tacacccacc      600

cacagtcacc aacacattac ctgctctcca aggttaggcg tggcaggaga agtttgcttg      660

gaccagcaga aaccatgcag tcaaggacaa ctggagtcag catgggctgg gtgcgagccc      720

ttggtggggt ggggaggaga ctccaggtca tacctcctgg aggatgtttt aatcatttcc      780

agcatggaat gctgtcaact tttgccacag attcattagc tctgagtttc ttttttctgt      840

ccccagctac cccttacatg tcaatatgga cttaatgatg ggaaattcag gcaagttttt      900

aaacatttta ttccccctgg ctcttatcct caaaaaatgc atgagttcgt tacctgattc      960

attccctggt tcctttcaca gtcctccgtg acccaagtgt tagggttttg gtctctctac     1020

tatttgtagg ctgatatata gtatacacac acacacacac acacatatac acacacacag     1080

tgtatcttga gctttctttt gtatatctac acacatatgt ataagaaagc tcaagatata     1140

gaagcccttt ttcaaaaata actgaaagtt tcaaactctt taagtctcca gttaccattt     1200

tgctggtatt cttatttgga accatacatt catcatattg ttgcacagta agactataca     1260

ttcattattt tgcttaaacg tatgagttaa aacacttggc caggcatggt ggttcacacc     1320

tgtaatccca gagctttggg aagccaagac tggcagatct cttgagctca ggaattcaag     1380

accagcctgg gcaacatgga aaaaccccat ctctacaaaa gatagaaaaa ttagccaggc     1440

atggtggcgt gtgcctgtgg tcccagctac tcaggaggct gaggtgggag gatcacatta     1500

gcccaggagg ttgaggctgc agtgagccgt gattatgcca ctgcactcca gcctgggaga     1560

cagagtgaga ccctgtttca aaaaaaagag agagaaaatt taaaaaagaa aacaacacca     1620

agggctgtaa ctttaaggtc attaaatgaa ttaatcactg cattcaaaaa cgattacttt     1680

ctggccctaa gagacatgag gccaatacca ggaagggggt tgatctccca aaccagaggc     1740

agaccctaga ctctaataca gttaaggaaa gaccagcaag atgatagtcc ccaatacaat     1800

agaagttact atattttatt tgttgttttt cttttgtttt gttttgtttt gttttgtttt     1860

gttttagaga ctggggtctt gctcgattgc ccaggctgta gtgcagcggt gggacaatag     1920

ctcactgcag actccaactc ctgggctcaa gcaatcctcc tgcctcagcc tcctgaatag     1980

ctgggactac aagggtacac catcacacac accaaaacaa ttttttaaat ttttgtgtag     2040

aaacgagggt cttgctttgt tgcccaggct ggtctccaac tcctggcttc aagggatcct     2100

cccacctcag cctcccaaat tgctgggatt acaggtgtga gccaccacaa ccagccagaa     2160

ctttactaat tttaaaatta agaacttaaa acttgaatag ctagagcacc aagatttttc     2220

tttgtcccca aataagtgca gttgcaggca tagaaaatct gacatctttg caagaatcat     2280

cgtggatgta gactctgtcc tgtgtctctg gcctggtttc ggggaccagg agggcagacc     2340

cttgcactgc caagaagcat gccaaagtta atcattggcc ctgctgagta catggccgat     2400

caggctgttt ttgtgtgcct gtttttctat tttacgtaaa tcaccctgaa catgtttgca     2460

tcaacctact ggtgatgcac ctttgatcaa tacattttag acaaacgtgg tttttgagtc     2520

caaagatcag ggctgggttg acctgaatac tggatacagg gcatataaaa caggggcaag     2580

gcacagactc atagcagagc aatcaccacc aagcctggaa taactgcaag ggctctgctg     2640

acatcttcct gaggtgccaa ggaaatgagg                                      2670


<210>  8
<211>  2528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: wildtype GPE but lacking Alu 
       - 2

<400>  8
cctttgagaa tccacggtgt ctcgatgcag tcagctttct aacaagctgg ggcctcacct       60

gttttcccac ggataaaaac gtgctggagg aagcagaaag gggctggcag gtggaaagat      120

gaggaccagc tcatcgtctc atgactatga ggttgctctg atccagaggg tccccctgcc      180

tggtggccca ccgccaggaa gactcccact gtccctggat gcccagagtg ggatgtcaac      240

tccatcactt atcaactcct tatccatagg ggtattcttc ctgaggcgtc tcagaaaaca      300

gggccctccc catatgctga ccacataata gaacccctcc caactcagag accctggctg      360

ctagctgccc tggcatgacc cagacagtgg cctttgtata tgtttttaga ctcaccttga      420

ctcacctctg accatagaaa ctctcatccc agaggtcact gcaatagtta ctccacaaca      480

gaggcttatc tgggtagagg gaggctccct acctatggcc cagcagccct gacagtgcag      540

atcacatata ccccacgccc cagcactgcc tgccacgcat gggcttactt tacacccacc      600

cacagtcacc aacacattac ctgctctcca aggttaggcg tggcaggaga agtttgcttg      660

gaccagcaga aaccatgcag tcaaggacaa ctggagtcag catgggctgg gtgcgagccc      720

ttggtggggt ggggaggaga ctccaggtca tacctcctgg aggatgtttt aatcatttcc      780

agcatggaat gctgtcaact tttgccacag attcattagc tctgagtttc ttttttctgt      840

ccccagctac cccttacatg tcaatatgga cttaatgatg ggaaattcag gcaagttttt      900

aaacatttta ttccccctgg ctcttatcct caaaaaatgc atgaatttgg aggcagtggc      960

tcatgcctgt aatcccaatg ctttgctagg ttgaggcggg aggatcactt gaagccagga     1020

atttgagacc agcctgggcc gcatagtgag accccgtttc tacaaaaata aataaataaa     1080

taataaataa tagtgatatg aagcatgatt aaatagccct attttttaaa atgcatgagt     1140

tcgttacctg attcattccc tggttccttt cacagtcctc cgtgacccaa gtgttagggt     1200

tttggtctct ctactatttg taggctgata tatagtatac acacacacac acacacacat     1260

atacacacac acagtgtatc ttgagctttc ttttgtatat ctacacacat atgtataaga     1320

aagctcaaga tatagaagcc ctttttcaaa aataactgaa agtttcaaac tctttaagtc     1380

tccagttacc attttgctgg tattcttatt tggaaccata cattcatcat attgttgcac     1440

agtaagacta tacattcatt attttgctta aacgtatgag ttaaaacact ttaaggtcat     1500

taaatgaatt aatcactgca ttcaaaaacg attactttct ggccctaaga gacatgaggc     1560

caataccagg aagggggttg atctcccaaa ccagaggcag accctagact ctaatacagt     1620

taaggaaaga ccagcaagat gatagtcccc aatacaatag aagttactat attttatttg     1680

ttgtttttct tttgttttgt tttgttttgt tttgttttgt tttagagact ggggtcttgc     1740

tcgattgccc aggctgtagt gcagcggtgg gacaatagct cactgcagac tccaactcct     1800

gggctcaagc aatcctcctg cctcagcctc ctgaatagct gggactacaa gggtacacca     1860

tcacacacac caaaacaatt ttttaaattt ttgtgtagaa acgagggtct tgctttgttg     1920

cccaggctgg tctccaactc ctggcttcaa gggatcctcc cacctcagcc tcccaaattg     1980

ctgggattac aggtgtgagc caccacaacc agccagaact ttactaattt taaaattaag     2040

aacttaaaac ttgaatagct agagcaccaa gatttttctt tgtccccaaa taagtgcagt     2100

tgcaggcata gaaaatctga catctttgca agaatcatcg tggatgtaga ctctgtcctg     2160

tgtctctggc ctggtttcgg ggaccaggag ggcagaccct tgcactgcca agaagcatgc     2220

caaagttaat cattggccct gctgagtaca tggccgatca ggctgttttt gtgtgcctgt     2280

ttttctattt tacgtaaatc accctgaaca tgtttgcatc aacctactgg tgatgcacct     2340

ttgatcaata cattttagac aaacgtggtt tttgagtcca aagatcaggg ctgggttgac     2400

ctgaatactg gatacagggc atataaaaca ggggcaaggc acagactcat agcagagcaa     2460

tcaccaccaa gcctggaata actgcaaggg ctctgctgac atcttcctga ggtgccaagg     2520

aaatgagg                                                              2528


<210>  9
<211>  2508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: wildtype GPE but  lacking Alu
       - 3

<400>  9
cctttgagaa tccacggtgt ctcgatgcag tcagctttct aacaagctgg ggcctcacct       60

gttttcccac ggataaaaac gtgctggagg aagcagaaag gggctggcag gtggaaagat      120

gaggaccagc tcatcgtctc atgactatga ggttgctctg atccagaggg tccccctgcc      180

tggtggccca ccgccaggaa gactcccact gtccctggat gcccagagtg ggatgtcaac      240

tccatcactt atcaactcct tatccatagg ggtattcttc ctgaggcgtc tcagaaaaca      300

gggccctccc catatgctga ccacataata gaacccctcc caactcagag accctggctg      360

ctagctgccc tggcatgacc cagacagtgg cctttgtata tgtttttaga ctcaccttga      420

ctcacctctg accatagaaa ctctcatccc agaggtcact gcaatagtta ctccacaaca      480

gaggcttatc tgggtagagg gaggctccct acctatggcc cagcagccct gacagtgcag      540

atcacatata ccccacgccc cagcactgcc tgccacgcat gggcttactt tacacccacc      600

cacagtcacc aacacattac ctgctctcca aggttaggcg tggcaggaga agtttgcttg      660

gaccagcaga aaccatgcag tcaaggacaa ctggagtcag catgggctgg gtgcgagccc      720

ttggtggggt ggggaggaga ctccaggtca tacctcctgg aggatgtttt aatcatttcc      780

agcatggaat gctgtcaact tttgccacag attcattagc tctgagtttc ttttttctgt      840

ccccagctac cccttacatg tcaatatgga cttaatgatg ggaaattcag gcaagttttt      900

aaacatttta ttccccctgg ctcttatcct caaaaaatgc atgaatttgg aggcagtggc      960

tcatgcctgt aatcccaatg ctttgctagg ttgaggcggg aggatcactt gaagccagga     1020

atttgagacc agcctgggcc gcatagtgag accccgtttc tacaaaaata aataaataaa     1080

taataaataa tagtgatatg aagcatgatt aaatagccct attttttaaa atgcatgagt     1140

tcgttacctg attcattccc tggttccttt cacagtcctc cgtgacccaa gtgttagggt     1200

tttggtctct ctactatttg taggctgata tatagtatac acacacacac acacacacat     1260

atacacacac acagtgtatc ttgagctttc ttttgtatat ctacacacat atgtataaga     1320

aagctcaaga tatagaagcc ctttttcaaa aataactgaa agtttcaaac tctttaagtc     1380

tccagttacc attttgctgg tattcttatt tggaaccata cattcatcat attgttgcac     1440

agtaagacta tacattcatt attttgctta aacgtatgag ttaaaacact tggccaggca     1500

tggtggttca cacctgtaat cccagagctt tgggaagcca agactggcag atctcttgag     1560

ctcaggaatt caagaccagc ctgggcaaca tggaaaaacc ccatctctac aaaagataga     1620

aaaattagcc aggcatggtg gcgtgtgcct gtggtcccag ctactcagga ggctgaggtg     1680

ggaggatcac attagcccag gaggttgagg ctgcagtgag ccgtgattat gccactgcac     1740

tccagcctgg gagacagagt gagaccctgt ttcaaaaaaa agagagagaa aatttaaaaa     1800

agaaaacaac accaagggct gtaactttaa ggtcattaaa tgaattaatc actgcattca     1860

aaaacgatta ctttctggcc ctaagagaca tgaggccaat accaggaagg gggttgatct     1920

cccaaaccag aggcagaccc tagactctaa tacagttaag gaaagaccag caagatgata     1980

gtccccaata caatagaact ttactaattt taaaattaag aacttaaaac ttgaatagct     2040

agagcaccaa gatttttctt tgtccccaaa taagtgcagt tgcaggcata gaaaatctga     2100

catctttgca agaatcatcg tggatgtaga ctctgtcctg tgtctctggc ctggtttcgg     2160

ggaccaggag ggcagaccct tgcactgcca agaagcatgc caaagttaat cattggccct     2220

gctgagtaca tggccgatca ggctgttttt gtgtgcctgt ttttctattt tacgtaaatc     2280

accctgaaca tgtttgcatc aacctactgg tgatgcacct ttgatcaata cattttagac     2340

aaacgtggtt tttgagtcca aagatcaggg ctgggttgac ctgaatactg gatacagggc     2400

atataaaaca ggggcaaggc acagactcat agcagagcaa tcaccaccaa gcctggaata     2460

actgcaaggg ctctgctgac atcttcctga ggtgccaagg aaatgagg                  2508


<210>  10
<211>  2334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: wildtype GPE, but lacking Alu
       - 1 and Alu - 2

<400>  10
cctttgagaa tccacggtgt ctcgatgcag tcagctttct aacaagctgg ggcctcacct       60

gttttcccac ggataaaaac gtgctggagg aagcagaaag gggctggcag gtggaaagat      120

gaggaccagc tcatcgtctc atgactatga ggttgctctg atccagaggg tccccctgcc      180

tggtggccca ccgccaggaa gactcccact gtccctggat gcccagagtg ggatgtcaac      240

tccatcactt atcaactcct tatccatagg ggtattcttc ctgaggcgtc tcagaaaaca      300

gggccctccc catatgctga ccacataata gaacccctcc caactcagag accctggctg      360

ctagctgccc tggcatgacc cagacagtgg cctttgtata tgtttttaga ctcaccttga      420

ctcacctctg accatagaaa ctctcatccc agaggtcact gcaatagtta ctccacaaca      480

gaggcttatc tgggtagagg gaggctccct acctatggcc cagcagccct gacagtgcag      540

atcacatata ccccacgccc cagcactgcc tgccacgcat gggcttactt tacacccacc      600

cacagtcacc aacacattac ctgctctcca aggttaggcg tggcaggaga agtttgcttg      660

gaccagcaga aaccatgcag tcaaggacaa ctggagtcag catgggctgg gtgcgagccc      720

ttggtggggt ggggaggaga ctccaggtca tacctcctgg aggatgtttt aatcatttcc      780

agcatggaat gctgtcaact tttgccacag attcattagc tctgagtttc ttttttctgt      840

ccccagctac cccttacatg tcaatatgga cttaatgatg ggaaattcag gcaagttttt      900

aaacatttta ttccccctgg ctcttatcct caaaaaatgc atgagttcgt tacctgattc      960

attccctggt tcctttcaca gtcctccgtg acccaagtgt tagggttttg gtctctctac     1020

tatttgtagg ctgatatata gtatacacac acacacacac acacatatac acacacacag     1080

tgtatcttga gctttctttt gtatatctac acacatatgt ataagaaagc tcaagatata     1140

gaagcccttt ttcaaaaata actgaaagtt tcaaactctt taagtctcca gttaccattt     1200

tgctggtatt cttatttgga accatacatt catcatattg ttgcacagta agactataca     1260

ttcattattt tgcttaaacg tatgagttaa aacactttaa ggtcattaaa tgaattaatc     1320

actgcattca aaaacgatta ctttctggcc ctaagagaca tgaggccaat accaggaagg     1380

gggttgatct cccaaaccag aggcagaccc tagactctaa tacagttaag gaaagaccag     1440

caagatgata gtccccaata caatagaagt tactatattt tatttgttgt ttttcttttg     1500

ttttgttttg ttttgttttg ttttgtttta gagactgggg tcttgctcga ttgcccaggc     1560

tgtagtgcag cggtgggaca atagctcact gcagactcca actcctgggc tcaagcaatc     1620

ctcctgcctc agcctcctga atagctggga ctacaagggt acaccatcac acacaccaaa     1680

acaatttttt aaatttttgt gtagaaacga gggtcttgct ttgttgccca ggctggtctc     1740

caactcctgg cttcaaggga tcctcccacc tcagcctccc aaattgctgg gattacaggt     1800

gtgagccacc acaaccagcc agaactttac taattttaaa attaagaact taaaacttga     1860

atagctagag caccaagatt tttctttgtc cccaaataag tgcagttgca ggcatagaaa     1920

atctgacatc tttgcaagaa tcatcgtgga tgtagactct gtcctgtgtc tctggcctgg     1980

tttcggggac caggagggca gacccttgca ctgccaagaa gcatgccaaa gttaatcatt     2040

ggccctgctg agtacatggc cgatcaggct gtttttgtgt gcctgttttt ctattttacg     2100

taaatcaccc tgaacatgtt tgcatcaacc tactggtgat gcacctttga tcaatacatt     2160

ttagacaaac gtggtttttg agtccaaaga tcagggctgg gttgacctga atactggata     2220

cagggcatat aaaacagggg caaggcacag actcatagca gagcaatcac caccaagcct     2280

ggaataactg caagggctct gctgacatct tcctgaggtg ccaaggaaat gagg           2334


<210>  11
<211>  2172
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: wildtype GPE, but lacking Alu
       - 2 and Alu - 3

<400>  11
cctttgagaa tccacggtgt ctcgatgcag tcagctttct aacaagctgg ggcctcacct       60

gttttcccac ggataaaaac gtgctggagg aagcagaaag gggctggcag gtggaaagat      120

gaggaccagc tcatcgtctc atgactatga ggttgctctg atccagaggg tccccctgcc      180

tggtggccca ccgccaggaa gactcccact gtccctggat gcccagagtg ggatgtcaac      240

tccatcactt atcaactcct tatccatagg ggtattcttc ctgaggcgtc tcagaaaaca      300

gggccctccc catatgctga ccacataata gaacccctcc caactcagag accctggctg      360

ctagctgccc tggcatgacc cagacagtgg cctttgtata tgtttttaga ctcaccttga      420

ctcacctctg accatagaaa ctctcatccc agaggtcact gcaatagtta ctccacaaca      480

gaggcttatc tgggtagagg gaggctccct acctatggcc cagcagccct gacagtgcag      540

atcacatata ccccacgccc cagcactgcc tgccacgcat gggcttactt tacacccacc      600

cacagtcacc aacacattac ctgctctcca aggttaggcg tggcaggaga agtttgcttg      660

gaccagcaga aaccatgcag tcaaggacaa ctggagtcag catgggctgg gtgcgagccc      720

ttggtggggt ggggaggaga ctccaggtca tacctcctgg aggatgtttt aatcatttcc      780

agcatggaat gctgtcaact tttgccacag attcattagc tctgagtttc ttttttctgt      840

ccccagctac cccttacatg tcaatatgga cttaatgatg ggaaattcag gcaagttttt      900

aaacatttta ttccccctgg ctcttatcct caaaaaatgc atgaatttgg aggcagtggc      960

tcatgcctgt aatcccaatg ctttgctagg ttgaggcggg aggatcactt gaagccagga     1020

atttgagacc agcctgggcc gcatagtgag accccgtttc tacaaaaata aataaataaa     1080

taataaataa tagtgatatg aagcatgatt aaatagccct attttttaaa atgcatgagt     1140

tcgttacctg attcattccc tggttccttt cacagtcctc cgtgacccaa gtgttagggt     1200

tttggtctct ctactatttg taggctgata tatagtatac acacacacac acacacacat     1260

atacacacac acagtgtatc ttgagctttc ttttgtatat ctacacacat atgtataaga     1320

aagctcaaga tatagaagcc ctttttcaaa aataactgaa agtttcaaac tctttaagtc     1380

tccagttacc attttgctgg tattcttatt tggaaccata cattcatcat attgttgcac     1440

agtaagacta tacattcatt attttgctta aacgtatgag ttaaaacact ttaaggtcat     1500

taaatgaatt aatcactgca ttcaaaaacg attactttct ggccctaaga gacatgaggc     1560

caataccagg aagggggttg atctcccaaa ccagaggcag accctagact ctaatacagt     1620

taaggaaaga ccagcaagat gatagtcccc aatacaatag aactttacta attttaaaat     1680

taagaactta aaacttgaat agctagagca ccaagatttt tctttgtccc caaataagtg     1740

cagttgcagg catagaaaat ctgacatctt tgcaagaatc atcgtggatg tagactctgt     1800

cctgtgtctc tggcctggtt tcggggacca ggagggcaga cccttgcact gccaagaagc     1860

atgccaaagt taatcattgg ccctgctgag tacatggccg atcaggctgt ttttgtgtgc     1920

ctgtttttct attttacgta aatcaccctg aacatgtttg catcaaccta ctggtgatgc     1980

acctttgatc aatacatttt agacaaacgt ggtttttgag tccaaagatc agggctgggt     2040

tgacctgaat actggataca gggcatataa aacaggggca aggcacagac tcatagcaga     2100

gcaatcacca ccaagcctgg aataactgca agggctctgc tgacatcttc ctgaggtgcc     2160

aaggaaatga gg                                                         2172


<210>  12
<211>  2314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: wildtype GPE, but lacking Alu
       - 1 and Alu - 3

<400>  12
cctttgagaa tccacggtgt ctcgatgcag tcagctttct aacaagctgg ggcctcacct       60

gttttcccac ggataaaaac gtgctggagg aagcagaaag gggctggcag gtggaaagat      120

gaggaccagc tcatcgtctc atgactatga ggttgctctg atccagaggg tccccctgcc      180

tggtggccca ccgccaggaa gactcccact gtccctggat gcccagagtg ggatgtcaac      240

tccatcactt atcaactcct tatccatagg ggtattcttc ctgaggcgtc tcagaaaaca      300

gggccctccc catatgctga ccacataata gaacccctcc caactcagag accctggctg      360

ctagctgccc tggcatgacc cagacagtgg cctttgtata tgtttttaga ctcaccttga      420

ctcacctctg accatagaaa ctctcatccc agaggtcact gcaatagtta ctccacaaca      480

gaggcttatc tgggtagagg gaggctccct acctatggcc cagcagccct gacagtgcag      540

atcacatata ccccacgccc cagcactgcc tgccacgcat gggcttactt tacacccacc      600

cacagtcacc aacacattac ctgctctcca aggttaggcg tggcaggaga agtttgcttg      660

gaccagcaga aaccatgcag tcaaggacaa ctggagtcag catgggctgg gtgcgagccc      720

ttggtggggt ggggaggaga ctccaggtca tacctcctgg aggatgtttt aatcatttcc      780

agcatggaat gctgtcaact tttgccacag attcattagc tctgagtttc ttttttctgt      840

ccccagctac cccttacatg tcaatatgga cttaatgatg ggaaattcag gcaagttttt      900

aaacatttta ttccccctgg ctcttatcct caaaaaatgc atgagttcgt tacctgattc      960

attccctggt tcctttcaca gtcctccgtg acccaagtgt tagggttttg gtctctctac     1020

tatttgtagg ctgatatata gtatacacac acacacacac acacatatac acacacacag     1080

tgtatcttga gctttctttt gtatatctac acacatatgt ataagaaagc tcaagatata     1140

gaagcccttt ttcaaaaata actgaaagtt tcaaactctt taagtctcca gttaccattt     1200

tgctggtatt cttatttgga accatacatt catcatattg ttgcacagta agactataca     1260

ttcattattt tgcttaaacg tatgagttaa aacacttggc caggcatggt ggttcacacc     1320

tgtaatccca gagctttggg aagccaagac tggcagatct cttgagctca ggaattcaag     1380

accagcctgg gcaacatgga aaaaccccat ctctacaaaa gatagaaaaa ttagccaggc     1440

atggtggcgt gtgcctgtgg tcccagctac tcaggaggct gaggtgggag gatcacatta     1500

gcccaggagg ttgaggctgc agtgagccgt gattatgcca ctgcactcca gcctgggaga     1560

cagagtgaga ccctgtttca aaaaaaagag agagaaaatt taaaaaagaa aacaacacca     1620

agggctgtaa ctttaaggtc attaaatgaa ttaatcactg cattcaaaaa cgattacttt     1680

ctggccctaa gagacatgag gccaatacca ggaagggggt tgatctccca aaccagaggc     1740

agaccctaga ctctaataca gttaaggaaa gaccagcaag atgatagtcc ccaatacaat     1800

agaactttac taattttaaa attaagaact taaaacttga atagctagag caccaagatt     1860

tttctttgtc cccaaataag tgcagttgca ggcatagaaa atctgacatc tttgcaagaa     1920

tcatcgtgga tgtagactct gtcctgtgtc tctggcctgg tttcggggac caggagggca     1980

gacccttgca ctgccaagaa gcatgccaaa gttaatcatt ggccctgctg agtacatggc     2040

cgatcaggct gtttttgtgt gcctgttttt ctattttacg taaatcaccc tgaacatgtt     2100

tgcatcaacc tactggtgat gcacctttga tcaatacatt ttagacaaac gtggtttttg     2160

agtccaaaga tcagggctgg gttgacctga atactggata cagggcatat aaaacagggg     2220

caaggcacag actcatagca gagcaatcac caccaagcct ggaataactg caagggctct     2280

gctgacatct tcctgaggtg ccaaggaaat gagg                                 2314


<210>  13
<211>  301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Intron

<400>  13
agctttattg cggtagttta tcacagttaa attgctaacg cagtcagtgc ttctgacaca       60

acagtctcga acttaagctg cagtgactct cttaaggtag ccttgcagaa gttggtcgtg      120

aggcactggg caggtaagta tcaaggttac aagacaggtt taaggagacc aatagaaact      180

gggcttgtcg agacagagaa gactcttgcg tttctgatag gcacctattg gtcttactga      240

catccacttt gcctttctct ccacaggtgt ccactcccag ttcaattaca gctcttaagg      300

c                                                                      301


<210>  14
<211>  137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: SV40 polyA tail

<400>  14
ggccgctatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa       60

taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg      120

ggaggttttt taggcat                                                     137


<210>  15
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: AAV2 ITR

<400>  15
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


