                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  ANTI-ANGPTL3/8 COMPLEX ANTIBODIES AND METHODS OF USING THE SAME

<130>  X22621

<150>  US 62/783,260
<151>  2018-12-21

<150>  US 62/783,265
<151>  2018-12-21

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  2951
<212>  DNA
<213>  Homo sapiens

<400>  1
atatatagag ttaagaagtc taggtctgct tccagaagaa aacagttcca cgttgcttga       60

aattgaaaat caagataaaa atgttcacaa ttaagctcct tctttttatt gttcctctag      120

ttatttcctc cagaattgat caagacaatt catcatttga ttctctatct ccagagccaa      180

aatcaagatt tgctatgtta gacgatgtaa aaattttagc caatggcctc cttcagttgg      240

gacatggtct taaagacttt gtccataaga cgaagggcca aattaatgac atatttcaaa      300

aactcaacat atttgatcag tctttttatg atctatcgct gcaaaccagt gaaatcaaag      360

aagaagaaaa ggaactgaga agaactacat ataaactaca agtcaaaaat gaagaggtaa      420

agaatatgtc acttgaactc aactcaaaac ttgaaagcct cctagaagaa aaaattctac      480

ttcaacaaaa agtgaaatat ttagaagagc aactaactaa cttaattcaa aatcaacctg      540

aaactccaga acacccagaa gtaacttcac ttaaaacttt tgtagaaaaa caagataata      600

gcatcaaaga ccttctccag accgtggaag accaatataa acaattaaac caacagcata      660

gtcaaataaa agaaatagaa aatcagctca gaaggactag tattcaagaa cccacagaaa      720

tttctctatc ttccaagcca agagcaccaa gaactactcc ctttcttcag ttgaatgaaa      780

taagaaatgt aaaacatgat ggcattcctg ctgaatgtac caccatttat aacagaggtg      840

aacatacaag tggcatgtat gccatcagac ccagcaactc tcaagttttt catgtctact      900

gtgatgttat atcaggtagt ccatggacat taattcaaca tcgaatagat ggatcacaaa      960

acttcaatga aacgtgggag aactacaaat atggttttgg gaggcttgat ggagaatttt     1020

ggttgggcct agagaagata tactccatag tgaagcaatc taattatgtt ttacgaattg     1080

agttggaaga ctggaaagac aacaaacatt atattgaata ttctttttac ttgggaaatc     1140

acgaaaccaa ctatacgcta catctagttg cgattactgg caatgtcccc aatgcaatcc     1200

cggaaaacaa agatttggtg ttttctactt gggatcacaa agcaaaagga cacttcaact     1260

gtccagaggg ttattcagga ggctggtggt ggcatgatga gtgtggagaa aacaacctaa     1320

atggtaaata taacaaacca agagcaaaat ctaagccaga gaggagaaga ggattatctt     1380

ggaagtctca aaatggaagg ttatactcta taaaatcaac caaaatgttg atccatccaa     1440

cagattcaga aagctttgaa tgaactgagg caaatttaaa aggcaataat ttaaacatta     1500

acctcattcc aagttaatgt ggtctaataa tctggtatta aatccttaag agaaagcttg     1560

agaaatagat tttttttatc ttaaagtcac tgtctattta agattaaaca tacaatcaca     1620

taaccttaaa gaataccgtt tacatttctc aatcaaaatt cttataatac tatttgtttt     1680

aaattttgtg atgtgggaat caattttaga tggtcacaat ctagattata atcaataggt     1740

gaacttatta aataactttt ctaaataaaa aatttagaga cttttatttt aaaaggcatc     1800

atatgagcta atatcacaac tttcccagtt taaaaaacta gtactcttgt taaaactcta     1860

aacttgacta aatacagagg actggtaatt gtacagttct taaatgttgt agtattaatt     1920

tcaaaactaa aaatcgtcag cacagagtat gtgtaaaaat ctgtaataca aatttttaaa     1980

ctgatgcttc attttgctac aaaataattt ggagtaaatg tttgatatga tttatttatg     2040

aaacctaatg aagcagaatt aaatactgta ttaaaataag ttcgctgtct ttaaacaaat     2100

ggagatgact actaagtcac attgacttta acatgaggta tcactatacc ttatttgtta     2160

aaatatatac tgtatacatt ttatatattt taacacttaa tactatgaaa acaaataatt     2220

gtaaaggaat cttgtcagat tacagtaaga atgaacatat ttgtggcatc gagttaaagt     2280

ttatatttcc cctaaatatg ctgtgattct aatacattcg tgtaggtttt caagtagaaa     2340

taaacctcgt aacaagttac tgaacgttta aacagcctga caagcatgta tatatgttta     2400

aaattcaata aacaaagacc cagtccctaa attatagaaa tttaaattat tcttgcatgt     2460

ttatcgacat cacaacagat ccctaaatcc ctaaatccct aaagattaga tacaaatttt     2520

ttaccacagt atcacttgtc agaatttatt tttaaatatg attttttaaa actgccagta     2580

agaaatttta aattaaaccc atttgttaaa ggatatagtg cccaagttat atggtgacct     2640

acctttgtca atacttagca ttatgtattt caaattatcc aatatacatg tcatatatat     2700

ttttatatgt cacatatata aaagatatgt atgatctatg tgaatcctaa gtaaatattt     2760

tgttccagaa aagtacaaaa taataaaggt aaaaataatc tataattttc aggaccacag     2820

actaagctgt cgaaattaac gctgattttt ttagggccag aataccaaaa tggctcctct     2880

cttcccccaa aattggacaa tttcaaatgc aaaataattc attatttaat atatgagttg     2940

cttcctctat t                                                          2951


<210>  2
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser 
1               5                   10                  15      


Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
    130                 135                 140                 


Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu 
145                 150                 155                 160 


Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 
                165                 170                 175     


Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln 
            180                 185                 190         


His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile 
        195                 200                 205             


Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg 
    210                 215                 220                 


Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
225                 230                 235                 240 


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
                245                 250                 255     


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            260                 265                 270         


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        275                 280                 285             


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    290                 295                 300                 


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
305                 310                 315                 320 


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                325                 330                 335     


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            340                 345                 350         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        355                 360                 365             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    370                 375                 380                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
385                 390                 395                 400 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                405                 410                 415     


Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            420                 425                 430         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        435                 440                 445             


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    450                 455                 460 


<210>  3
<211>  888
<212>  DNA
<213>  Homo sapiens

<400>  3
ataccttaga ccctcagtca tgccagtgcc tgctctgtgc ctgctctggg ccctggcaat       60

ggtgacccgg cctgcctcag cggcccccat gggcggccca gaactggcac agcatgagga      120

gctgaccctg ctcttccatg ggaccctgca gctgggccag gccctcaacg gtgtgtacag      180

gaccacggag ggacggctga caaaggccag gaacagcctg ggtctctatg gccgcacaat      240

agaactcctg gggcaggagg tcagccgggg ccgggatgca gcccaggaac ttcgggcaag      300

cctgttggag actcagatgg aggaggatat tctgcagctg caggcagagg ccacagctga      360

ggtgctgggg gaggtggccc aggcacagaa ggtgctacgg gacagcgtgc agcggctaga      420

agtccagctg aggagcgcct ggctgggccc tgcctaccga gaatttgagg tcttaaaggc      480

tcacgctgac aagcagagcc acatcctatg ggccctcaca ggccacgtgc agcggcagag      540

gcgggagatg gtggcacagc agcatcggct gcgacagatc caggagagac tccacacagc      600

ggcgctccca gcctgaatct gcctggatgg aactgaggac caatcatgct gcaaggaaca      660

cttccacgcc ccgtgaggcc cctgtgcagg gaggagctgc ctgttcactg ggatcagcca      720

gggcgccggg ccccacttct gagcacagag cagagacaga cgcaggcggg gacaaaggca      780

gaggatgtag ccccattggg gaggggtgga ggaaggacat gtaccctttc atgcctacac      840

acccctcatt aaagcagagt cgtggcatct caaaaaaaaa aaaaaaaa                   888


<210>  4
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Val Pro Ala Leu Cys Leu Leu Trp Ala Leu Ala Met Val Thr 
1               5                   10                  15      


Arg Pro Ala Ser Ala Ala Pro Met Gly Gly Pro Glu Leu Ala Gln His 
            20                  25                  30          


Glu Glu Leu Thr Leu Leu Phe His Gly Thr Leu Gln Leu Gly Gln Ala 
        35                  40                  45              


Leu Asn Gly Val Tyr Arg Thr Thr Glu Gly Arg Leu Thr Lys Ala Arg 
    50                  55                  60                  


Asn Ser Leu Gly Leu Tyr Gly Arg Thr Ile Glu Leu Leu Gly Gln Glu 
65                  70                  75                  80  


Val Ser Arg Gly Arg Asp Ala Ala Gln Glu Leu Arg Ala Ser Leu Leu 
                85                  90                  95      


Glu Thr Gln Met Glu Glu Asp Ile Leu Gln Leu Gln Ala Glu Ala Thr 
            100                 105                 110         


Ala Glu Val Leu Gly Glu Val Ala Gln Ala Gln Lys Val Leu Arg Asp 
        115                 120                 125             


Ser Val Gln Arg Leu Glu Val Gln Leu Arg Ser Ala Trp Leu Gly Pro 
    130                 135                 140                 


Ala Tyr Arg Glu Phe Glu Val Leu Lys Ala His Ala Asp Lys Gln Ser 
145                 150                 155                 160 


His Ile Leu Trp Ala Leu Thr Gly His Val Gln Arg Gln Arg Arg Glu 
                165                 170                 175     


Met Val Ala Gln Gln His Arg Leu Arg Gln Ile Gln Glu Arg Leu His 
            180                 185                 190         


Thr Ala Ala Leu Pro Ala 
        195             


<210>  5
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Met Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  6
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Ile Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Arg Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Leu Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Tyr Ser Ser Gly Trp Tyr Gly Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly 
    


<210>  7
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
gatattgtga tgacccagac ccccctgtct ctgcctgtca ctccggggga accggcctcg       60

atctcatgcc ggtcgagcca gtccctgctg gactccgatg acgggaacac ttatttggat      120

tggtacctcc aaaagcctgg acagagcccg cagctcctga tctacatgct gtcctaccgg      180

gcctccggag tgccagaccg cttctcggga agcggctccg gtaccgactt cacactgaag      240

atctcccgcg tggaagctga ggacgtgggc atctactact gtatgcaaag aatcgagttc      300

cccctcacct tcggcggcgg gactaaggtc gagattaaga gaaccgtggc cgcaccatcc      360

gtgttcattt ttcccccgtc cgatgaacag ctgaagtccg gaaccgcctc cgtcgtgtgc      420

ctgctcaaca acttctaccc gagggaagcg aaagtgcagt ggaaagtgga caatgcgctg      480

cagtccggaa actcccaaga gtccgtgacc gaacaggact ccaaggactc aacctactcg      540

ctgagctcaa cgctgaccct gagcaaggcc gactacgaga agcacaaggt ctacgcctgc      600

gaagtgaccc atcagggttt gagctcgccc gtgaccaagt ccttcaaccg gggagagtgc      660


<210>  8
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
caagtcacat tgaaggagag cggtccgacc ctggtcaagc cgactcagac cctgaccctg       60

acgtgcactt tctcgggctt ctcattgtcc atttctggag tgggcgtggg atggatcaga      120

cagcccccgg ggaaggccct cgagtggctc gcgctgatct accgcaacga cgacaaacgc      180

tactccccct cactgaaatc ccggctgacc atcactaagg atacgtccaa gaaccaggtc      240

gtgttgaccc tcaccaacat ggatcccgtg gatactgcca cctactattg tgcacggacc      300

tatagcagcg gttggtacgg aaactggttc gacccgtggg gccagggaac tcttgtgacg      360

gtgtcctccg caagcaccaa gggtccttct gtgttccccc tggcgccgtg ctcgcggagc      420

acctcagagt ccaccgccgc cctcggctgc cttgtgaagg actacttccc ggagccagtc      480

accgtgtcct ggaacagcgg ggccctgact tccggcgtgc acaccttccc tgcggtgctg      540

cagagctcag gcctctattc gctgtcatcc gtcgtgaccg tgccttcctc gtccctgggc      600

actaagacct acacttgcaa cgtggaccat aagcccagca acaccaaagt ggacaagaga      660

gtggaatcca aatacggacc gccatgtccg ccctgccccg ccccggaagc tgccggggga      720

cccagcgtgt tcctgttccc acctaagccg aaggacactc tgatgatctc aaggactccc      780

gaagtcactt gcgtggtcgt ggacgtgtcc caggaggacc ccgaagtcca gtttaattgg      840

tacgtggatg gtgtcgaggt ccacaacgcc aagaccaagc ctcgcgagga acagttcaat      900

tccacctacc gggtcgtgtc cgtcctgacc gtgctgcatc aggactggct gaacggaaag      960

gagtacaagt gcaaagtgtc caacaaggga ctcccttcct ccatcgaaaa gaccatcagc     1020

aaggccaagg gccagcctcg cgaaccacaa gtctacaccc tgcccccatc gcaagaggaa     1080

atgaccaaga accaagtgtc gctgacatgc ctcgtcaagg gattctaccc gtcggatatt     1140

gcggtggaat gggagtccaa cggacagccc gagaacaact acaagaccac cccgccggtg     1200

ttggactccg acggctcctt tttcctgtac tcccggctca ctgtggacaa gtcgcggtgg     1260

caggagggga acgtgttctc ctgttccgtg atgcacgaag ctctgcacaa ccactacacc     1320

cagaagtcgc tgagcctctc actggga                                         1347


<210>  9
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Met Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  10
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Ile Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Arg Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Leu Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Tyr Ser Ser Gly Trp Tyr Gly Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Tyr Met Leu Ser Tyr Arg Ala Ser 
1               5               


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Met Gln Arg Ile Glu Phe Pro Leu Thr 
1               5                   


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Thr Phe Ser Gly Phe Ser Leu Ser Ile Ser Gly Val Gly Val Gly 
1               5                   10                  15  


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Leu Ile Tyr Arg Asn Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Ala Arg Thr Tyr Ser Ser Gly Trp Tyr Gly Asn Trp Phe Asp Pro 
1               5                   10                  15  


<210>  17
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser 
1               5                   10                  15      


Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
    130                 135                 140                 


Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu 
145                 150                 155                 160 


Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 
                165                 170                 175     


Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln 
            180                 185                 190         


His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile 
        195                 200                 205             


Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg 
    210                 215                 220                 


Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
225                 230                 235                 240 


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
                245                 250                 255     


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            260                 265                 270         


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        275                 280                 285             


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    290                 295                 300                 


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
305                 310                 315                 320 


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                325                 330                 335     


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            340                 345                 350         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        355                 360                 365             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    370                 375                 380                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
385                 390                 395                 400 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                405                 410                 415     


Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            420                 425                 430         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        435                 440                 445             


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu Ala Ala Ala Asp 
    450                 455                 460                 


Tyr Lys Asp Asp Asp Asp Lys 
465                 470     


<210>  18
<211>  820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp His His His His His His Asp Ala His Lys Ser 
            20                  25                  30          


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
        35                  40                  45              


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu 
    50                  55                  60                  


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
65                  70                  75                  80  


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
                85                  90                  95      


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
            100                 105                 110         


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
        115                 120                 125             


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
    130                 135                 140                 


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
145                 150                 155                 160 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
                165                 170                 175     


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
            180                 185                 190         


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
        195                 200                 205             


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
    210                 215                 220                 


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
225                 230                 235                 240 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
                245                 250                 255     


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
            260                 265                 270         


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
        275                 280                 285             


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
    290                 295                 300                 


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
305                 310                 315                 320 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
                325                 330                 335     


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
            340                 345                 350         


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
        355                 360                 365             


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
    370                 375                 380                 


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
385                 390                 395                 400 


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
                405                 410                 415     


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
            420                 425                 430         


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
        435                 440                 445             


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
    450                 455                 460                 


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
465                 470                 475                 480 


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
                485                 490                 495     


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
            500                 505                 510         


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
        515                 520                 525             


Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
    530                 535                 540                 


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
545                 550                 555                 560 


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
                565                 570                 575     


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
            580                 585                 590         


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
        595                 600                 605             


Ala Leu Gly Leu Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
    610                 615                 620                 


Ala Pro Ala Pro Ala Pro Ala Pro Leu Glu Val Leu Phe Gln Gly Pro 
625                 630                 635                 640 


Gly Arg Ala Ala Pro Met Gly Gly Pro Glu Leu Ala Gln His Glu Glu 
                645                 650                 655     


Leu Thr Leu Leu Phe His Gly Thr Leu Gln Leu Gly Gln Ala Leu Asn 
            660                 665                 670         


Gly Val Tyr Arg Thr Thr Glu Gly Arg Leu Thr Lys Ala Arg Asn Ser 
        675                 680                 685             


Leu Gly Leu Tyr Gly Arg Thr Ile Glu Leu Leu Gly Gln Glu Val Ser 
    690                 695                 700                 


Arg Gly Arg Asp Ala Ala Gln Glu Leu Arg Ala Ser Leu Leu Glu Thr 
705                 710                 715                 720 


Gln Met Glu Glu Asp Ile Leu Gln Leu Gln Ala Glu Ala Thr Ala Glu 
                725                 730                 735     


Val Leu Gly Glu Val Ala Gln Ala Gln Lys Val Leu Arg Asp Ser Val 
            740                 745                 750         


Gln Arg Leu Glu Val Gln Leu Arg Ser Ala Trp Leu Gly Pro Ala Tyr 
        755                 760                 765             


Arg Glu Phe Glu Val Leu Lys Ala His Ala Asp Lys Gln Ser His Ile 
    770                 775                 780                 


Leu Trp Ala Leu Thr Gly His Val Gln Arg Gln Arg Arg Glu Met Val 
785                 790                 795                 800 


Ala Gln Gln His Arg Leu Arg Gln Ile Gln Glu Arg Leu His Thr Ala 
                805                 810                 815     


Ala Leu Pro Ala 
            820 


<210>  19
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 
1               5                   10                  15      


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
            20                  25                  30          


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
        35                  40                  45              


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
    50                  55                  60                  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
65                  70                  75                  80  


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
                85                  90                  95      


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
            100                 105                 110         


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
        115                 120                 125             


Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu 
    130                 135                 140                 


Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 
145                 150                 155                 160 


Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln 
                165                 170                 175     


His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile 
            180                 185                 190         


Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg 
        195                 200                 205             


Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
    210                 215                 220                 


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
225                 230                 235                 240 


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
                245                 250                 255     


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
            260                 265                 270         


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
        275                 280                 285             


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
    290                 295                 300                 


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
305                 310                 315                 320 


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
                325                 330                 335     


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
            340                 345                 350         


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
        355                 360                 365             


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
    370                 375                 380                 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
385                 390                 395                 400 


Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Leu 
                405                 410                 415     


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
            420                 425                 430         


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu Ala Ala Ala Asp 
        435                 440                 445             


Tyr Lys Asp Asp Asp Asp Lys 
    450                 455 


<210>  20
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Gly Pro Gly Arg Ala Ala Pro Met Gly Gly Pro Glu Leu Ala Gln His 
1               5                   10                  15      


Glu Glu Leu Thr Leu Leu Phe His Gly Thr Leu Gln Leu Gly Gln Ala 
            20                  25                  30          


Leu Asn Gly Val Tyr Arg Thr Thr Glu Gly Arg Leu Thr Lys Ala Arg 
        35                  40                  45              


Asn Ser Leu Gly Leu Tyr Gly Arg Thr Ile Glu Leu Leu Gly Gln Glu 
    50                  55                  60                  


Val Ser Arg Gly Arg Asp Ala Ala Gln Glu Leu Arg Ala Ser Leu Leu 
65                  70                  75                  80  


Glu Thr Gln Met Glu Glu Asp Ile Leu Gln Leu Gln Ala Glu Ala Thr 
                85                  90                  95      


Ala Glu Val Leu Gly Glu Val Ala Gln Ala Gln Lys Val Leu Arg Asp 
            100                 105                 110         


Ser Val Gln Arg Leu Glu Val Gln Leu Arg Ser Ala Trp Leu Gly Pro 
        115                 120                 125             


Ala Tyr Arg Glu Phe Glu Val Leu Lys Ala His Ala Asp Lys Gln Ser 
    130                 135                 140                 


His Ile Leu Trp Ala Leu Thr Gly His Val Gln Arg Gln Arg Arg Glu 
145                 150                 155                 160 


Met Val Ala Gln Gln His Arg Leu Arg Gln Ile Gln Glu Arg Leu His 
                165                 170                 175     


Thr Ala Ala Leu Pro Ala 
            180         


<210>  21
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Met Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  22
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Ala Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Met Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  23
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Thr Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Met Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  24
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  25
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Met Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Ile Gln Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


