                         SEQUENCE LISTING

<110>  Birad - Research & Development Company Ltd.
 
<120>  Anti-Hepatitis C virus antibodies

<130>  2690584

<150>  US 62/781,634
<151>  2018-12-19

<160>  211   

<170>  PatentIn version 3.5

<210>  1
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSHOOTER-sec-E2-1a-SE

<400>  1
gggaaaggta ccgtcctctc tcgtgatcga gggtaggcct gaattcagta ccatggccga       60

aacccacgtc accgg                                                        75


<210>  2
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSHOOTER-sec-E2-1a-AS

<400>  2
gggaatgcgg ccgcctcgga cctgtccctg                                        30


<210>  3
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TAB-RI

<400>  3
ccatgattac gccaagcttg ggagcc                                            26


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CBD-As

<400>  4
gaattcaacc ttcaaattgc c                                                 21


<210>  5
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK1-1

<400>  5
tttaagccat ggcccaggtb cagctkgtrc artctgg                                37


<210>  6
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK1-2

<400>  6
tttaagccat ggcccaratg cagctggtgc agtctgg                                37


<210>  7
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK1-3

<400>  7
tttaagccat ggccgargts cagctggtrc agtctgg                                37


<210>  8
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK2-1

<400>  8
tttaagccat ggcccagatc accttgaagg agtctgg                                37


<210>  9
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK2-2

<400>  9
tttaagccat ggcccaggtc accttgaggg agtctgg                                37


<210>  10
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK2-3

<400>  10
tttaagccat ggcccaggtc accttgaagg agtctgg                                37


<210>  11
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK3-1

<400>  11
tttaagccat ggccgargtr carctggtgg agtcygg                                37


<210>  12
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK3-2

<400>  12
tttaagccat ggcccaggtg cagctggtgg agtctgg                                37


<210>  13
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK3-3

<400>  13
tttaagccat ggccgaggtg cagctgttgg agtctgg                                37


<210>  14
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK3-4

<400>  14
tttaagccat ggccgaggtg cagctggtgg agwctg                                 36


<210>  15
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK4-1

<400>  15
tttaagccat ggcccaggtg carctgcagg agtcggg                                37


<210>  16
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK4-2

<400>  16
tttaagccat ggcccagctg cagctgcagg agtcsgg                                37


<210>  17
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VH-NcoI-BACK6-1

<400>  17
tttaagccat ggcccaggta cagctgcagc agtcagg                                37


<210>  18
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JH-FORF1-2-4-5

<400>  18
tcctgctgag cctgaggaga crgtgaccag ggtkcc                                 36


<210>  19
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JH-FORF3

<400>  19
tcctgctgag cctgaagaga cggtgaccat tgtccc                                 36


<210>  20
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JH-FORF6

<400>  20
tcctgctgag cctgaggaga cggtgaccgt ggtccc                                 36


<210>  21
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JH-FORF1-2-4-5L

<400>  21
ccaccaccac cggatcctcc tcctcctgct gagcctgagg agacrgtgac cagggtkcc        59


<210>  22
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JH-FORF3L

<400>  22
ccaccaccac cggatcctcc tcctcctgct gagcctgaag agacggtgac cattgtccc        59


<210>  23
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JH-FORF6L

<400>  23
ccaccaccac cggatcctcc tcctcctgct gagcctgagg agacggtgac cgtggtccc        59


<210>  24
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VK-BACKF1S

<400>  24
ggcggcggct ccrhcatcyr gwtgacccag tc                                     32


<210>  25
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VK-BACKF2-4S

<400>  25
ggcggcggct ccgayrtygt gatgacycag wc                                     32


<210>  26
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VK-BACKF3S

<400>  26
ggcggcggct ccgaaatwgt rwtgacrcag tc                                     32


<210>  27
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VK-BACKF5S

<400>  27
ggcggcggct ccgaaacgac actcacgcag tc                                     32


<210>  28
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VK-BACKF6S

<400>  28
ggcggcggct ccgawrttgt gmtgacwcag tc                                     32


<210>  29
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VK-Lin-BACKF1L

<400>  29
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctccrh catcyrgwtg       60

acccagtc                                                                68


<210>  30
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VK-Lin-BACKF2-4L

<400>  30
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctccga yrtygtgatg       60

acycagwc                                                                68


<210>  31
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VK-Lin-BACKF3L

<400>  31
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctccga aatwgtrwtg       60

acrcagtc                                                                68


<210>  32
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VK-Lin-BACKF5L

<400>  32
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctccga aacgacactc       60

acgcagtc                                                                68


<210>  33
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VK-L-BACKF6L

<400>  33
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctccga wrttgtgmtg       60

acwcagtc                                                                68


<210>  34
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JK-NotI-FORF1-3-4

<400>  34
atatatgcgg ccgctttgat htccacyttg gtcc                                   34


<210>  35
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JK-NotI-FORF2

<400>  35
atatatgcgg ccgctttgat ctccagcttg gtcc                                   34


<210>  36
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JK-NotI-FORF5

<400>  36
atatatgcgg ccgctttaat ctccagtcgt gtcc                                   34


<210>  37
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF1S

<400>  37
ggcggcggct cccagtctgt sbtgackcag cc                                     32


<210>  38
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF2S

<400>  38
ggcggcggct cccagtctgc cctgactcag cc                                     32


<210>  39
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF3S

<400>  39
ggcggcggct cctcytmtgw gctgacwcag cc                                     32


<210>  40
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF3DEGS

<400>  40
ggcggcggct cctcctatga gctgayhcag swvc                                   34


<210>  41
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF4-5

<400>  41
ggcggcggct cccagsytgt gctgactcaa yc                                     32


<210>  42
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF6S

<400>  42
ggcggcggct ccaattttat gctgactcag cc                                     32


<210>  43
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF7-8S

<400>  43
ggcggcggct cccagrctgt ggtgacycag g                                      31


<210>  44
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF9-10S

<400>  44
ggcggcggct cccwgscwgk gctgactcag cc                                     32


<210>  45
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF1L

<400>  45
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctccca gtctgtsbtg       60

ackcagcc                                                                68


<210>  46
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF2L

<400>  46
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctccca gtctgccctg       60

actcagcc                                                                68


<210>  47
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF3L

<400>  47
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctcctc ytmtgwgctg       60

acwcagcc                                                                68


<210>  48
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF3DEGL

<400>  48
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctcctc ctatgagctg       60

ayhcagswvc                                                              70


<210>  49
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF4-5L

<400>  49
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctccca gsytgtgctg       60

actcaayc                                                                68


<210>  50
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF6L

<400>  50
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctccaa ttttatgctg       60

actcagcc                                                                68


<210>  51
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF7-8L

<400>  51
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctccca grctgtggtg       60

acycagg                                                                 67


<210>  52
<211>  68
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-VL-BACKF9-10L

<400>  52
ggatccggtg gtggtggttc cggaggcggc ggctccggcg gcggctcccw gscwgkgctg       60

actcagcc                                                                68


<210>  53
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JL-NotI-FORF1-2-3

<400>  53
atatatgcgg ccgctaggac ggtsacctts gtccc                                  35


<210>  54
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JL-NotI-FORF4

<400>  54
atatatgcgg ccgctaggac gatcagctgg gttcc                                  35


<210>  55
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JL-NotI-FORF5

<400>  55
atatatgcgg ccgctaggac ggtcagctcs gtccc                                  35


<210>  56
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu-JL-NotI-FORF6-7

<400>  56
atatatgcgg ccgctaggac ggtcasctkg gtkcc                                  35


<210>  57
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC1 VH

<400>  57
gaggtgcagc tggtggagtc cggggggggc ttggtaaagc ctggggagtc cctcagactc       60

tcctgtgcag cctctggatt caccttcagt gactattgga tgacttgggt ccgccaggct      120

ccagggaagg tgctggagtg ggtttcaggc attagtggga gtgccactaa gacatactac      180

gcagactctg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagtt      300

actacccggg ggcttgctct tgatatctgg ggccaaggga ccacggtcac cgtctcctca      360


<210>  58
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC1 VH

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Val Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Ala Thr Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Thr Thr Arg Gly Leu Ala Leu Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC1 VH CDR1

<400>  59

Gly Phe Thr Phe Ser Asp Tyr Trp 
1               5               


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC1 VH CDR2

<400>  60

Gly Ile Ser Gly Ser Ala Thr Lys Thr 
1               5                   


<210>  61
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC1 VH CDR3

<400>  61

Ala Arg Glu Val Thr Thr Arg Gly Leu Ala Leu Asp Ile 
1               5                   10              


<210>  62
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC1 VL KAPPA

<400>  62
gacattgtga tgacccagac tccaggcacc ctgtctttgt ctccagggga aagagctacc       60

ctctcctgca gggccagtca gactgttagc ggcaggtatt tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcgtcca gcggggccac tggcatccca      180

gacaggtcca gtggcagcgg gtctgggaca gatttcactc tcaccatcag cagcctgcag      240

gctgaagatg tggcagttta ttactgtcag caatattata gttacccccc tatcaccttc      300

ggccaaggga cacgactgga gattaaa                                          327


<210>  63
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC1 VL KAPPA

<400>  63

Asp Ile Val Met Thr Gln Thr Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Gly Ala Thr Gly Ile Pro Asp Arg Ser Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC1 VL KAPPA CDR1

<400>  64

Gln Thr Val Ser Gly Arg Tyr 
1               5           


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC1 VL KAPPA CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is null

<400>  65

Xaa Gly Ala Ser 
1               


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC1 VL KAPPA CDR3

<400>  66

Gln Gln Tyr Tyr Ser Tyr Pro Pro Ile Thr 
1               5                   10  


<210>  67
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC3 VH

<400>  67
caggtcacct tgagggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg       60

acctgcaccg tctctggatt ctcactcagc gatgatgaag tgggtgtggg ctggatccgt      120

cagcccccag ggcaggccct ggagtggctt gcactcattt attgggatga tgataagcgc      180

tacagcccat ctctgaggaa cagactcacc atcaccaagg acacctccaa aaaccaggtg      240

gtccttacaa tcaccaacat ggcccctgtt gacacggcca catattactg tgcgcactta      300

ctgctctata ccagaaaaga tgcttttgat ttctggggcc aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  68
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC3 VH

<400>  68

Gln Val Thr Leu Arg Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asp Asp 
            20                  25                  30          


Glu Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Gln Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Arg Asn Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Ile Thr Asn Met Ala Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Leu Leu Leu Tyr Thr Arg Lys Asp Ala Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC3 VH CDR1

<400>  69

Gly Phe Ser Leu Ser Asp Asp Glu Val Gly Val 
1               5                   10      


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC3 VH CDR2

<400>  70

Ile Tyr Trp Asp Asp Asp Lys Arg 
1               5               


<210>  71
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC3 VL LAMBDA

<400>  71
tcctatgagc tgacacagcc accctcagtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaactt tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccacctcagg gacaacagtc acgttgacca tcagtggagt ccaggcagaa      240

gacgaggctg actattactg tcagtcagca gacagcagtg gtacttatgt cttcggaact      300

gggaccaagg tcaccgtc                                                    318


<210>  72
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC3 VL LAMBDA

<400>  72

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Phe Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Tyr 
                85                  90                  95      


Val Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105     


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC3 VL LAMBDA CDR1

<400>  73

Asn Phe Gly Ser Lys Ser 
1               5       


<210>  74
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC3 VL LAMBDA CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is null

<400>  74

Xaa Asp Asp Ser 
1               


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC3 VL LAMBDA CDR3

<400>  75

Gln Ser Ala Asp Ser Ser Gly Thr Tyr Val 
1               5                   10  


<210>  76
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC1 VH

<400>  76
caggtacagc tgcagcagtc aggtctggga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctta agttacagtg ctgcttggca ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc ccagtggttg      180

agtgaatctg cagtttctgt gaaaagtcga ataattttca actcagacac atccaagaac      240

cagttctccc tgcagctgca ctctgtgact cccgacgaca cggctgccta ttactgtgca      300

agagatgggg ggaaccacgg aaactactac aatctggacg tctggggcca agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  77
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC11 VH

<400>  77

Gln Val Gln Leu Gln Gln Ser Gly Leu Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Leu Ser Tyr 
            20                  25                  30          


Ser Ala Ala Trp His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Gln Trp Leu Ser Glu Ser Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Ile Phe Asn Ser Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu His Ser Val Thr Pro Asp Asp Thr Ala Ala 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Gly Gly Asn His Gly Asn Tyr Tyr Asn Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC11 VH CDR1

<400>  78

Gly Asp Ser Val Leu Ser Tyr Ser Ala Ala 
1               5                   10  


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC11 VH CDR2

<400>  79

Thr Tyr Tyr Arg Ser Gln Trp Leu Ser 
1               5                   


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC11 VH CDR3

<400>  80

Ala Arg Asp Gly Gly Asn His Gly Asn Tyr Tyr Asn Leu Asp Val 
1               5                   10                  15  


<210>  81
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC11 VL KAPPA

<400>  81
gacgtcgtga tgacacagac accagggaca ccctccctga gccccggcga gagagccaca       60

ctgtcctgcc gggccagcca gaccgtgtcc ggaaggtacc tggcctggta ccagcagaag      120

cccggccagg cccccaggct gctgatctac ggggccagca gcagggccac aggcatcccc      180

gataggttca gcgggagcgg gagcgggacc gatttcacac tgaccatcag ccggctgggc      240

cccgaggatt ttgccgtgta ttactgtctt cagtacggct ccagccctta cacctttggg      300

caaggcacta aactggagat t                                                321


<210>  82
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC11 VL KAPPA

<400>  82

Asp Val Val Met Thr Gln Thr Pro Gly Thr Pro Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gly 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105         


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC11 VL KAPPA CDR1

<400>  83

Gln Thr Val Ser Gly Arg Tyr 
1               5           


<210>  84
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V1-46*J5*13*27


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  may be substituted by t

<400>  84
tgcgcgagag atgtgggctg ggcccgggcg ggcgggccct gg                          42


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC11 VL KAPPA CDR3

<400>  85

Leu Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   


<210>  86
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CI16 VH

<400>  86
gaggtgcagc tgttggagtt tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agttatgaaa tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccctc tccagaggca acgccaagaa ttcactgtat      240

ctgcaaatga acagcctgag agtcgacgac acggctgtat attactgtgc gagaggcgac      300

tacggtgacg acatttttgc cgatgctttt gatatctggg gccaaggcac cctggtcacc      360

gtctcctca                                                              369


<210>  87
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI 16 VH

<400>  87

Glu Val Gln Leu Leu Glu Phe Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Gly Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Gly Asp Asp Ile Phe Ala Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI 16 VH CDR1

<400>  88

Gly Phe Thr Phe Ser Ser Tyr Glu 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI 16 VH CDR2

<400>  89

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI16 VH CDR3

<400>  90

Ala Arg Gly Asp Tyr Gly Asp Asp Ile Phe Ala Asp Ala Phe Asp Ile 
1               5                   10                  15      


<210>  91
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CI 16 VL KAPPA

<400>  91
gaagttgtgc tgacacagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gactgttagc ggcaggtatt tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcaatgta ttactgtcag cagtatggta gctcaccgta cacttttggc      300

caggggacca agctggagat caaa                                             324


<210>  92
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI 16 VL KAPPA

<400>  92

Glu Val Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr 
            100                 105                 110 


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI16 VL KAPPA CDR1

<400>  93

Gln Thr Val Ser Gly Arg Tyr 
1               5           


<210>  94
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V4-59*J4*16**31


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  may be substituted by c or a

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  may be substituted by T

<400>  94
tgtgcgagag gggggtatgt caagagctac gacaccattg actactgg                    48


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI16 VL KAPPA CDR3

<400>  95

Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   


<210>  96
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC17 VH

<400>  96
gtgcagctgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc       60

tgtgcagcct ctggattcac ctttagtagc tattggatga gttgggtccg ccaggcccca      120

gggaaggggc tggagtgggt ggccaacata aagcaagatg gaagtgagaa atactatgtg      180

gactctgtga agggccggtt caccatctcc agagacaatt ccaagaacac actgtatctg      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agaagttact      300

acccgggggc ttgctcttga tatctggggc cagggcaccc tggtcaccgt ctcctca         357


<210>  97
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC17 VH

<400>  97

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Trp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Val Thr Thr Arg Gly Leu Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC17 VH CDR1

<400>  98

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC17 VH CDR2

<400>  99

Ile Lys Gln Asp Gly Ser Glu Lys 
1               5               


<210>  100
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC17 VH CDR3

<400>  100

Ala Arg Glu Val Thr Thr Arg Gly Leu Ala Leu Asp Ile 
1               5                   10              


<210>  101
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC17 VL KAPPA

<400>  101
gaaatagtga tgacccagtc tccagtcatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcaaagaaca      120

aatggttctc cgaggcttct cataaagtat gctcctgagt ctacctctgg aatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtagagtct      240

gaagatattg cagattatta ctgtcaacaa aataataact ggccaaccac gttcggtgct      300

gggacacgac tggagattaa a                                                321


<210>  102
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC17 VL KAPPA

<400>  102

Glu Ile Val Met Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Pro Glu Ser Thr Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  103
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC17 VL KAPPA CDR1

<400>  103

Gln Ser Ile Gly Thr Asn 
1               5       


<210>  104
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC17 VL KAPPA CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is null

<400>  104

Xaa Tyr Ala Pro 
1               


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC17 VL KAPPA CDR3

<400>  105

Gln Gln Asn Asn Asn Trp Pro Thr Thr 
1               5                   


<210>  106
<211>  377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC28 VH

<400>  106
gcgcgcactc ccagctgcag ctgcaggagt cgggcccagg actggtgaag ccttcggaga       60

ccctgtccct cacctgcact gtttctggtg actccatcag cgttgatcac ttctggggct      120

ggatccgcca gcccccaggg aaggggctgg aatatattgg gagtatcctt tacactggaa      180

atacccacta taatccggcc ctcaggagtc gagtcatcat ctccgtagac acgtctaaga      240

accagttctc cctgaagctg agctctgtga ccgccgcaga cacggctgtg tattactgtg      300

cgagactggg cgcagcagca gctggtattc cgggccgtga ctactggggc caggggacca      360

cggtcaccgt ctcctca                                                     377


<210>  107
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC28 VH

<400>  107

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Val Asp 
            20                  25                  30          


His Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr 
        35                  40                  45              


Ile Gly Ser Ile Leu Tyr Thr Gly Asn Thr His Tyr Asn Pro Ala Leu 
    50                  55                  60                  


Arg Ser Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Ala Ala Ala Gly Ile Pro Gly Arg Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC28 VH CDR1

<400>  108

Gly Asp Ser Ile Ser Val Asp His Phe 
1               5                   


<210>  109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC28 VH CDR2

<400>  109

Ile Leu Tyr Thr Gly Asn Thr 
1               5           


<210>  110
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC28 VH CDR3

<400>  110

Ala Arg Leu Gly Ala Ala Ala Ala Gly Ile Pro Gly Arg Asp Tyr 
1               5                   10                  15  


<210>  111
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC28 VL KAPPA

<400>  111
gaaattgtgt tgactcaacc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gactgttagc ggcaggtatt tagcctggta ccagcaggaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagttta ttactgtcag cacagttaca gtcccaggta cacttttggg      300

acaggcacca aagtg                                                       315


<210>  112
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC28 VL KAPPA

<400>  112

Glu Ile Val Leu Thr Gln Pro Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Glu Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Tyr Ser Pro Arg 
                85                  90                  95      


Tyr Thr Phe Gly Thr Gly Thr Lys Val 
            100                 105 


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC28 VL KAPPA CDR1

<400>  113

Gln Thr Val Ser Gly Arg Tyr 
1               5           


<210>  114
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V2-26*J6*20**2


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by c, g or t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  may be substituted by a or c

<400>  114
tgtgcacggg tatcaacgga gttactgctg tggaattggt ggtactactt ggacgtctgg       60


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC28 VL KAPPA CDR3

<400>  115

Gln His Ser Tyr Ser Pro Arg Tyr Thr 
1               5                   


<210>  116
<211>  358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC76 VH

<400>  116
gaggtgcagt tggtggagac agggggcggc ctggtgcagc ccggcgggag cttgagattg       60

agctgtgcag ctagtggctt cacattttcc gactactgga tgacatgggt gaggcaggcg      120

cccggaaagg gcctcgagtg ggtgtccgga atctcaggat ccgccactaa gacctattac      180

gctgatagcg tgaaagggcg gttcaccatc tcacgcgata acagtaagaa cactctttac      240

ctccagatga acagcctgag agccgaggat acagccgtct actactgcgc cagggaggtc      300

accactcggg gcctggccct ggacatttgg ggccagggga ctatggtgac agtcagct        358


<210>  117
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC76 VH

<400>  117

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Ala Thr Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Thr Thr Arg Gly Leu Ala Leu Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val 
        115             


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC76 VH CDR1

<400>  118

Gly Phe Thr Phe Ser Asp Tyr Trp 
1               5               


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC76 VH CDR2

<400>  119

Ile Ser Gly Ser Ala Thr Lys Thr 
1               5               


<210>  120
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC76 VH CDR3

<400>  120

Ala Arg Glu Val Thr Thr Arg Gly Leu Ala Leu Asp Ile 
1               5                   10              


<210>  121
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC76 VL LAMBDA

<400>  121
acaggcgcgc actcccagga gcccagcctg accgtgagcc ccggcggcac agtgaccctg       60

acatgcgggt ccagcaccgg ggccgtgaca agcgggcact ggccctactg gttccagcag      120

aagcccggcc aggcacccag gacactgatc cacgatactt ccgataagga cagctggaca      180

ccagcccggt ttagcggctc actgctggga ggcaaagccg ccttgacact tagtggggcc      240

caaccagagg acgagtccga atactactgt ctcctgtcct acagcggggc tagagtcttc      300

ggcgggggaa ctgagctgac a                                                321


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC76 VL LAMBDA

<400>  122

Thr Gly Ala His Ser Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


His Trp Pro Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile His Asp Thr Ser Asp Lys Asp Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ser Glu Tyr Tyr Cys Leu Leu Ser Tyr Ser Gly 
                85                  90                  95      


Ala Arg Val Phe Gly Gly Gly Thr Glu Leu Thr 
            100                 105         


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC76 VL LAMBDA CDR1

<400>  123

Thr Gly Ala Val Thr Ser Gly His Trp 
1               5                   


<210>  124
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC76 VL LAMBDA CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is null

<400>  124

Xaa Asp Thr Ser 
1               


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC76 VL LAMBDA CDR3

<400>  125

Leu Leu Ser Tyr Ser Gly Ala Arg Val 
1               5                   


<210>  126
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CI 81 VH

<400>  126
gaggtacagc tggtggagtc cgggggaggc gtggtccagc ctgggaggtc ccttagactc       60

tcctgtgcag cctctggatt cacctttagt acctatgcca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta ctggtagtta catatactac      180

gcagactcac tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac atggctgtgt attactgtgc gagaggtgtg      300

ttagtaccag ctgctacctt acgttttgac tactggggcc agggcaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  127
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI 81 VH

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Thr Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Leu Val Pro Ala Ala Thr Leu Arg Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI 81 VH CDR1

<400>  128

Gly Phe Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI 81 VH CDR2

<400>  129

Ile Ser Ser Thr Gly Ser Tyr Ile 
1               5               


<210>  130
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI 81 VH CDR3

<400>  130

Ala Arg Gly Val Leu Val Pro Ala Ala Thr Leu Arg Phe Asp Tyr 
1               5                   10                  15  


<210>  131
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CI81 VL LAMBDA

<400>  131
cagtctgccc tgactcagcc agtctcaatg tcagtggccc tgggccagac ggccaccatc       60

tcctgcactg gaaccagcag tgatgttggt ggttatgact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc acctcagcct ccctggccgt cagtgggctc      240

cagtctgagg atgagtcttc ttattactgt gccgcatggg ataacagtgt gaatggtgtg      300

gtattcggcg gagggacgaa ggtcaccgtc cta                                   333


<210>  132
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI81 VL LAMBDA

<400>  132

Gln Ser Ala Leu Thr Gln Pro Val Ser Met Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ser Ser Tyr Tyr Cys Ala Ala Trp Asp Asn Ser 
                85                  90                  95      


Val Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI81 VL LAMBDA CDR1

<400>  133

Ser Ser Asp Val Gly Gly Tyr Asp Tyr 
1               5                   


<210>  134
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI81 VL LAMBDA CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is null

<400>  134

Xaa Asp Val Ser 
1               


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI81 VL LAMBDA CDR3

<400>  135

Ala Ala Trp Asp Asn Ser Val Asn Gly Val Val 
1               5                   10      


<210>  136
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CI 92 VH

<400>  136
caggtccagc tggtgcaatc tggggctgag gtgaggaagc ctgggtcctc ggtgaaggtc       60

tcttgtaagg cttctggagg caccttcagc aggtatccta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtag cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgt gagagcccgg      300

acgcggaacg ggcgcgttgg agtggccgta tggggccaag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  137
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI92 VH

<400>  137

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr 
            20                  25                  30          


Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Ser Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ala Arg Thr Arg Asn Gly Arg Val Gly Val Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI92 VH CDR1

<400>  138

Gly Thr Phe Ser Arg Tyr Pro 
1               5           


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI92 VH CDR2

<400>  139

Met Asn Pro Asn Ser Gly Ser Thr 
1               5               


<210>  140
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI92 VH CDR3

<400>  140

Val Arg Ala Arg Thr Arg Asn Gly Arg Val Gly Val Ala Val 
1               5                   10                  


<210>  141
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CI92 VL KAPPA


<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (280)..(280)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (306)..(306)
<223>  n is a, c, g, or t

<400>  141
gatgttgtga tgactcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gactgttagc ggcaggtatt tagcctggta ccancagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctggaaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagttta ttactgtcaa cacagttacn gtcccaggta cacttttggc      300

cagggnacca agctggagat caaa                                             324


<210>  142
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI92 VL KAPPA


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa can be any naturally occurring amino acid

<400>  142

Val Val Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Xaa Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Tyr Xaa Pro Arg Tyr 
                85                  90                  95      


Thr Phe Gly Gln Xaa Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI92 VL KAPPA CDR1

<400>  143

Gln Thr Val Ser Gly Arg Tyr 
1               5           


<210>  144
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIRST SEQUENCE ON FIGURE 8D

<400>  144

Cys Ala Ser Ser Leu Gly Gly Thr Glu Ala Phe Phe 
1               5                   10          


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CI92 VL KAPPA CDR3


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  145

Gln His Ser Tyr Xaa Pro Arg Tyr Thr 
1               5                   


<210>  146
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC93 VH

<400>  146
gtgcagctgc aggagtcggg gggaggcttg gtacagcctg gggggtccct gagactctcc       60

tgtgcagcct ctggattcgc cttcagtgac tattggatga cttgggtccg ccaggctcca      120

gggaagggcc tggagtgggt ttcaggcatt agtgggagtg ccactaagac atactacgca      180

gactctgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgagca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agaagttact      300

acccgggggc ttgctcttga tatctggggc caggggacca cggtcaccgt ctcctca         357


<210>  147
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC93 VH

<400>  147

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Ala Thr Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Thr Thr Arg Gly Leu Ala Leu Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC93 VH CDR1

<400>  148

Gly Phe Ala Phe Ser Asp Tyr Trp 
1               5               


<210>  149
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC93 VH CDR2

<400>  149

Ile Ser Gly Ser Ala Thr Lys Thr 
1               5               


<210>  150
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC93 VH CDR3

<400>  150

Ala Arg Glu Val Thr Thr Arg Gly Leu Ala Leu Asp Ile 
1               5                   10              


<210>  151
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SC93 VL KAPPA

<400>  151
accatccgga tgacccagtc tccaggcacc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcaaagaaca      120

aatggttctc cgaggcttct cataaagtat gctcctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaagatattg cagattatta ctgtcaacaa aataataact ggccaaccac gttcggtgct      300

gggacacgac tggagattaa a                                                321


<210>  152
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC93 VL KAPPA

<400>  152

Thr Ile Arg Met Thr Gln Ser Pro Gly Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Pro Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  153
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC93 VL KAPPA CDR1

<400>  153

Gln Ser Ile Gly Thr Asn 
1               5       


<210>  154
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-23*J4*10**707


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by a or t

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by c, t or a

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  may be substituted by t

<400>  154
tgtgtgaaag gggcgtggct tgactactgg                                        30


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC93 VL KAPPA CDR3

<400>  155

Gln Gln Asn Asn Asn Trp Pro Thr Thr 
1               5                   


<210>  156
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH510520 (RMS28) VH

<400>  156
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tttctggtga ctccatcagc gttgatcact tctggggctg gatccgccag      120

cccccaggga aggggctgga atatattggg agtatccttt acactggaaa tacccactat      180

aatccggccc tcaggagtcg agtcatcatc tccgtagaca cgtctaagaa tcagttctcc      240

ctgaacctga gctctgtgac cgccgcagac acggctgtat attactgtgc gagactgggg      300

ctgggcagca gctggttcta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  157
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH510520 (RMS28) VH

<400>  157

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Val Asp 
            20                  25                  30          


His Phe Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr 
        35                  40                  45              


Ile Gly Ser Ile Leu Tyr Thr Gly Asn Thr His Tyr Asn Pro Ala Leu 
    50                  55                  60                  


Arg Ser Arg Val Ile Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Leu Gly Ser Ser Trp Phe Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  158
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH510520 (RMS28) VH CDR1

<400>  158

Gly Asp Ser Ile Ser Val Asp His Phe 
1               5                   


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH510520 (RMS28) VH CDR2

<400>  159

Ile Leu Tyr Thr Gly Asn Thr 
1               5           


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH510520 (RMS28) VH CDR3

<400>  160

Ala Arg Leu Gly Leu Gly Ser Ser Trp Phe Tyr 
1               5                   10      


<210>  161
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH510520 (RMS28) VL KAPPA

<400>  161
gaaattgtgt tgactcaacc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gactgttagc ggcaggtatt tagcctggta ccagcaggaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagttta ttactgtcag cacagttaca gtcccaggta cacttttggg      300

acaggcacca aagtg                                                       315


<210>  162
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH510520 (RMS28) VL KAPPA

<400>  162

Glu Ile Val Leu Thr Gln Pro Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Glu Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Tyr Ser Pro Arg 
                85                  90                  95      


Tyr Thr Phe Gly Thr Gly Thr Lys Val 
            100                 105 


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH510520 (RMS28) VL KAPPA CDR1

<400>  163

Gln Thr Val Ser Gly Arg Tyr 
1               5           


<210>  164
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-15*J6*16**97

<400>  164
tgtaccacag gagcgccggg tgggttcgga ctactatttg gacgtctgg                   49


<210>  165
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH510520 (RMS28) VL KAPPA CDR3

<400>  165

Gln His Ser Tyr Ser Pro Arg Tyr Thr 
1               5                   


<210>  166
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH16618 (RMS11) VH

<400>  166
caggtacagc tgcagcagtc aggtctggga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctta agttacagtg ctgcttggca ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc ccagtggttg      180

agtgaatctg cagtttctgt gaaaagtcga ataattttca acccagacac atccaagaac      240

cagttctccc tgcagctgca ctctgtgact cccgacgaca cggctgtcta ttactgtgca      300

agagatgggg ggaaccacgg aaactactac aatctggacg tctggggcca agggaccacg      360

gtcaccgtct cctca                                                       375


<210>  167
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH16618 (RMS11) VH

<400>  167

Gln Val Gln Leu Gln Gln Ser Gly Leu Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Leu Ser Tyr 
            20                  25                  30          


Ser Ala Ala Trp His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Gln Trp Leu Ser Glu Ser Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Ile Phe Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu His Ser Val Thr Pro Asp Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Gly Gly Asn His Gly Asn Tyr Tyr Asn Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  168
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH16618 (RMS11) VH CDR1

<400>  168

Gly Asp Ser Val Leu Ser Tyr Ser Ala Ala 
1               5                   10  


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH16618 (RMS11) VH CDR2

<400>  169

Thr Tyr Tyr Arg Ser Gln Trp Leu Ser 
1               5                   


<210>  170
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH16618 (RMS11) VH CDR3

<400>  170

Ala Arg Asp Gly Gly Asn His Gly Asn Tyr Tyr Asn Leu Asp Val 
1               5                   10                  15  


<210>  171
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH16618 (RMS11) VL KAPPA

<400>  171
gacgtcgtga tgacacagac accagggaca ccctccctga gccccggcga gagagccaca       60

ctgtcctgcc gggccagcca gaccgtgtcc ggaaggtacc tggcctggta ccagcagaag      120

cccggccagg cccccaggct gctgatctac ggggccagca gcagggccac aggcatcccc      180

gataggttca gcgggagcgg gagcgggacc gatttcacac tgaccatcag ccggctgggc      240

cccgaggatt ttgccgtgta ttactgtctt cagtacggct ccagccctta cacctttggg      300

caaggcacta aactggagat t                                                321


<210>  172
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH16618 (RMS11) VL KAPPA

<400>  172

Asp Val Val Met Thr Gln Thr Pro Gly Thr Pro Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Gly Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gly 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105         


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH16618 (RMS11) VL KAPPA CDR1

<400>  173

Gln Thr Val Ser Gly Arg Tyr 
1               5           


<210>  174
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V4-34*J6*14**97


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  may be substituted by c

<400>  174
tgcggagaca tctctcggga tttaacgcta tggacgtctg g                           41


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH16618 (RMS11) VL KAPPA CDR3

<400>  175

Leu Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   


<210>  176
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CONSTANT REGION- HEAVY CHAIN

<400>  176
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctggggaga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggtaaa tga                                   993


<210>  177
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CONSTANT REGION- HEAVY CHAIN

<400>  177

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Arg Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  178
<211>  320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CONSTANT REGION- KAPPA LIGHT CHAIN

<400>  178
gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg       60

gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt      120

ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca      180

gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga      240

aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga      300

gcttcaacag gggagagtgt                                                  320


<210>  179
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CONSTANT REGION- KAPPA LIGHT CHAIN

<400>  179

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  180
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CONSTANT REGION - LAMBDA LIGHT CHAIN

<400>  180
ctaggtcagc ccaaggctgc cccctcggtc actctgttcc cgccctcctc tgaggagctt       60

caagccaaca aggccacact ggtgtgtctc ataagtgact tctacccggg agccgtgaca      120

gtggcctgga aggcagatag cagccccgtc aaggcgggag tggagaccac cacaccctcc      180

aaacaaagca acaacaagta cgcggccagc agctatctga gcctgacgcc tgagcagtgg      240

aagtcccaca gaagctacag ctgccaggtc acgcatgaag ggagcaccgt ggagaagaca      300

gtggcccctg cagaatgttc t                                                321


<210>  181
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CONSTANT REGION - LAMBDA LIGHT CHAIN

<400>  181

Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
1               5                   10                  15      


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
            20                  25                  30          


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
        35                  40                  45              


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
    50                  55                  60                  


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
65                  70                  75                  80  


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
                85                  90                  95      


Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105         


<210>  182
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC3 VH CDR3

<400>  182

Ala His Leu Leu Leu Tyr Thr Arg Lys Asp Ala Phe 
1               5                   10          


<210>  183
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  one of the best CDR3 in example 3

<400>  183

Cys Ala Ser Ser Thr Ala Gly Gln Gly Leu Thr Glu Ala Phe Phe 
1               5                   10                  15  


<210>  184
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQUENCE  10 IN FIGURE 8D

<400>  184

Cys Ala Ser Ser Leu Gly Thr Pro Asn Glu Gln Phe Phe 
1               5                   10              


<210>  185
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of binders

<400>  185

Phe Ala Leu Gly Ala Ala Ala Gly Ile Asp Tyr 
1               5                   10      


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of non-binders


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  may be substituted by Lys, Ile or Thr

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  may be substituted by Val, Ser, Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  may be substituted by Gln, Ile or Gly

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  may be substituted by Met, Asn, Val or Arg

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  may be substituted by Pro, Gly or Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  may be substituted by Tyr, Ile, Ser, or Gly

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  may be substituted by Pro, Thr, Ala or Leu

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  may be substituted by Leu, Val, Tyr or Glu

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  may be substituted by Ala, Phe, Arg or Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  may be substituted by Tyr or Gln

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  may be substituted by Tyr or Asn

<400>  186

Tyr Ala His Ser Ile Pro Glu Asp Tyr Pro Pro 
1               5                   10      


<210>  187
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-30*J4*8**9


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  may be substituted by g or a

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  may be substituted by c or g

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by a, c or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be substituted by g or t

<400>  187
tgtgcgaaag atcagggcta ctgg                                              24


<210>  188
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V1-69*J1*18**85


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be substituted by g

<400>  188
tgtgcgactg ttagggctag tgtgacccac cgggccgaat acttccaaca ctgg             54


<210>  189
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V4-39*J4*15**248

<400>  189
tgtgcgagag attctttggc agtggctggg acgattgact actgg                       45


<210>  190
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V6-1*J6*17**20


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  may be substituted by g

<400>  190
tgtgcaagag atggggggaa ccacggaaac tactacaatc tggacgtctg g                51


<210>  191
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-23*J6*20**367


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  may be substituted by g or c

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be substituted by c or g

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  may be substituted by a

<400>  191
tgtgcgaaag tagcggttat attgtggttc ggagagcggg gccggggatg gacgtctgg        59


<210>  192
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-15*J4*8**130


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by t, g or a

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be substituted by c, a or t

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  may be substituted by c or g

<400>  192
tgtaccacag atccccggta ctgg                                              24


<210>  193
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-43*J2*5**0

<400>  193
ataaaagacg atctc                                                        15


<210>  194
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQUENCE 2 ON FIG 8D

<400>  194

Cys Ala Ser Ser Leu Ala Gly Asp Gln Pro Gln His Phe 
1               5                   10              


<210>  195
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQUENCE 3 ON FIG 8D

<400>  195

Cys Ala Ser Ser Leu Ala Gly Gly Gln Glu Thr Gln Tyr Phe 
1               5                   10                  


<210>  196
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQUENCE 4 ON FIG 8D

<400>  196

Cys Ala Ser Ser Leu Gly Asn Thr Gly Glu Leu Phe Phe 
1               5                   10              


<210>  197
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQUENCE 5 ON FIG 8D

<400>  197

Cys Ala Ser Ser Leu Gly Ser Ser Gly Ala Asn Val Leu Thr Phe 
1               5                   10                  15  


<210>  198
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQUENCE 6 ON FIG 8D

<400>  198

Cys Ala Ser Ser Leu Arg Asn Thr Gly Glu Leu Phe Phe 
1               5                   10              


<210>  199
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQUENCE 7 ON FIG 8D

<400>  199

Cys Ala Ser Ser Gln Gly Asn Glu Gln Phe Phe 
1               5                   10      


<210>  200
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQUENCE 8 ON FIG 8D

<400>  200

Cys Ala Ser Ser Gln Gly Gly Tyr Glu Gln Tyr Phe 
1               5                   10          


<210>  201
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQUENCE 9 ON FIG 8D

<400>  201

Cys Ala Ser Ser Phe Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10          


<210>  202
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V4-59*J2*20**8


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  may be substituted by a, t or c

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  may be substituted by g, t or a

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by g or c

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  may be substituted by c or g

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  may be substituted by g, a or c

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  may be substituted by t

<400>  202
tgtgcgagag acgcatattg tagtggtggt agctgcttcg actggtactt cgatctctgg       60


<210>  203
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-30*J4*8**9


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  may be substituted by g or a

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  may be substituted by c or g

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by a, c or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be substituted by g or t

<400>  203
tgtgcgaaag atcagggcta ctgg                                              24


<210>  204
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-15*J4*7**99


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by t or g

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by t

<400>  204
tgtaccacag tcgactactg g                                                 21


<210>  205
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-23*J4*14**1433


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  may be substituted by g or a

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  may be substituted by g, t or a

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  may be substituted by t or g

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  may be substituted by c or g

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  may be substituted by c

<400>  205
tgtgcgaaat cccagtatag cagtggctgg tacgattact gg                          42


<210>  206
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-23*J4*10**707


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by a or t

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by c, t or a

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  may be substituted by g

<400>  206
tgtgtgaaag gggcgtggct tgactactgg                                        30


<210>  207
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-21*J6*17**240


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  may be substituted by c or g

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  may be substituted by t

<400>  207
tgtgcgagag agtattacag gctcgtccta ctactacggt atggacgtct gg               52


<210>  208
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-15*J4*8**130


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by t, g or a

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be substituted by c, a or t

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  may be substituted by c or g

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  may be substituted by t

<400>  208
tgtaccacag atccccggta ctgg                                              24


<210>  209
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V4-34*J6*13**72


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by c, t or a

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  may be substituted by a or c

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  may be substituted by c or t

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by a

<400>  209
tgtgcgaggg ggtactacta ctacggtatg gacgtctgg                              39


<210>  210
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V3-23*J6*20**367


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  may be substituted by g or c

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  may be substituted by c or g

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  may be substituted by c

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  may be substituted by c

<400>  210
tgtgcgaaag tagcggttat attgtggttc ggagagcggg gccgggggat ggacgtctgg       60


<210>  211
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V4-34*J6*14**103


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  may be substituted by a

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  may be substituted by g

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  may be substituted by t

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  may be substituted by c

<400>  211
tgcgcgagac atctctcggg atttaacgct atggacgtct gg                          42


