                         SEQUENCE LISTING

<110>  KYOWA KIRIN CO., LTD.
 
<120>  FN14 ANTIBODIES AND USES THEREOF

<130>  14233-010-228

<140>
<141>

<150>  US 62/782,912
<151>  2018-12-20

<160>  259   

<170>  PatentIn version 3.5

<210>  1
<211>  387
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Human Fn14 (full length)

<400>  1
atggctcggg gctcgctgcg ccggttgctg cggctcctcg tgctggggct ctggctggcg       60

ttgctgcgct ccgtggccgg ggagcaagcg ccaggcaccg ccccctgctc ccgcggcagc      120

tcctggagcg cggacctgga caagtgcatg gactgcgcgt cttgcagggc gcgaccgcac      180

agcgacttct gcctgggctg cgctgcagca cctcctgccc ccttccggct gctttggccc      240

atccttgggg gcgctctgag cctgaccttc gtgctggggc tgctttctgg ctttttggtc      300

tggagacgat gccgcaggag agagaagttc accaccccca tagaggagac cggcggagag      360

ggctgcccag ctgtggcgct gatccag                                          387


<210>  2
<211>  129
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human Fn14 (full length)

<400>  2

Met Ala Arg Gly Ser Leu Arg Arg Leu Leu Arg Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Trp Leu Ala Leu Leu Arg Ser Val Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala Pro Phe Arg Leu Leu Trp Pro 
65                  70                  75                  80  


Ile Leu Gly Gly Ala Leu Ser Leu Thr Phe Val Leu Gly Leu Leu Ser 
                85                  90                  95      


Gly Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr 
            100                 105                 110         


Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Ala Val Ala Leu Ile 
        115                 120                 125             


Gln 
    


<210>  3
<211>  144
<212>  DNA
<213>  Homo sapiens

<220>
<223>  human Fn14 fragment used for immunization (aa28-75)

<400>  3
gagcaagcgc caggcaccgc cccctgctcc cgcggcagct cctggagcgc ggacctggac       60

aagtgcatgg actgcgcgtc ttgcagggcg cgaccgcaca gcgacttctg cctgggctgc      120

gctgcagcac ctcctgcccc cttc                                             144


<210>  4
<211>  48
<212>  PRT
<213>  Homo sapiens

<220>
<223>  human Fn14 fragment used for immunization (aa28-75)

<400>  4

Glu Gln Ala Pro Gly Thr Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser 
1               5                   10                  15      


Ala Asp Leu Asp Lys Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro 
            20                  25                  30          


His Ser Asp Phe Cys Leu Gly Cys Ala Ala Ala Pro Pro Ala Pro Phe 
        35                  40                  45              


<210>  5
<211>  387
<212>  DNA
<213>  Mouse

<220>
<223>  mouse Fn14 (full length)

<400>  5
atggcttcgg cttggccgcg gtctctgccg cagatcctcg tgttgggatt cggcttggtg       60

ttgatgcgcg ccgcggccgg ggagcaagca ccaggcacct ccccatgctc tagcggcagc      120

tcctggagcg cggacctcga caagtgcatg gactgcgctt cttgtccagc gcgaccacac      180

agcgacttct gcctgggatg cgccgcagca cctcctgccc acttcaggct actgtggccc      240

attctggggg gcgctcttag tctggtcctg gttttggcgc tggtttctag tttcctggtc      300

tggagaagat gccgccggag agaaaagttt actaccccca tagaggagac tggtggagag      360

ggctgcccag gtgtggcact gatccag                                          387


<210>  6
<211>  129
<212>  PRT
<213>  Mouse

<220>
<223>  mouse Fn14 (full length)

<400>  6

Met Ala Ser Ala Trp Pro Arg Ser Leu Pro Gln Ile Leu Val Leu Gly 
1               5                   10                  15      


Phe Gly Leu Val Leu Met Arg Ala Ala Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ser Pro Cys Ser Ser Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Pro Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala His Phe Arg Leu Leu Trp Pro 
65                  70                  75                  80  


Ile Leu Gly Gly Ala Leu Ser Leu Val Leu Val Leu Ala Leu Val Ser 
                85                  90                  95      


Ser Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr 
            100                 105                 110         


Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Gly Val Ala Leu Ile 
        115                 120                 125             


Gln 
    


<210>  7
<211>  387
<212>  DNA
<213>  Rattus

<220>
<223>  rat Fn14 (full length)

<400>  7
atggctccgg gttggccgcg gcctctgccg cagctcctcg tgttgggatt cgggttggtg       60

ttgatacgcg ccacggccgg ggagcaagca ccaggcaacg ccccatgctc aagcggcagc      120

tcctggagcg cggacctcga caagtgcatg gactgcgctt cttgtccagc gcgaccacac      180

agcgacttct gcctgggatg cgcagcagca cctcctgccc acttcaggat gctatggccc      240

attctgggag gcgctcttag tctggccctg gttttggcgc tggtttctgg tttcctggtc      300

tggagacgat gccgccggag agaaaagttt actaccccca tagaggagac tggtggagaa      360

ggctgcccag gtgtggcact gatccag                                          387


<210>  8
<211>  129
<212>  PRT
<213>  Rattus

<220>
<223>  rat Fn14 (full length)

<400>  8

Met Ala Pro Gly Trp Pro Arg Pro Leu Pro Gln Leu Leu Val Leu Gly 
1               5                   10                  15      


Phe Gly Leu Val Leu Ile Arg Ala Thr Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Asn Ala Pro Cys Ser Ser Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Pro Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala His Phe Arg Met Leu Trp Pro 
65                  70                  75                  80  


Ile Leu Gly Gly Ala Leu Ser Leu Ala Leu Val Leu Ala Leu Val Ser 
                85                  90                  95      


Gly Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr 
            100                 105                 110         


Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Gly Val Ala Leu Ile 
        115                 120                 125             


Gln 
    


<210>  9
<211>  390
<212>  DNA
<213>  Macaca fascicularis

<220>
<223>  cynomolgus (Macaca fascicularis) Fn14 (full length)

<400>  9
atggctcggg gttcgctgcg ccggttgctg cggctcctcg tgctggggct ctggctggcg       60

ttgctgcgct ccgtggctgg ggagcaagcg ccaggcaccg ccccctgctc ccacggcagt      120

tcctggagcg cggacctgga caagtgcatg gactgcgcgt cttgcagggc gcgaccgcac      180

agcgacttct gcctgggctg ctctgcggca cctcctgccc ccttccggct gctttggccc      240

atccttgggg gcgctctgag tctgaccttc gtgctggggc tgctttctgg ctttctggtc      300

tggagacgat gccgcaggag agagaagttc accaccccca tagaggagac cggcggagag      360

ggctgcccag ctgtggcgct gatccagtga                                       390


<210>  10
<211>  129
<212>  PRT
<213>  Macaca fascicularis

<220>
<223>  cynomolgus (Macaca fascicularis) Fn14 (full length)

<400>  10

Met Ala Arg Gly Ser Leu Arg Arg Leu Leu Arg Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Trp Leu Ala Leu Leu Arg Ser Val Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ala Pro Cys Ser His Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ser Ala Ala Pro Pro Ala Pro Phe Arg Leu Leu Trp Pro 
65                  70                  75                  80  


Ile Leu Gly Gly Ala Leu Ser Leu Thr Phe Val Leu Gly Leu Leu Ser 
                85                  90                  95      


Gly Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr 
            100                 105                 110         


Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Ala Val Ala Leu Ile 
        115                 120                 125             


Gln 
    


<210>  11
<211>  465
<212>  DNA
<213>  Homo sapiens

<220>
<223>  His-SUMO-hFn14

<400>  11
catcatcacc accatcacgg gtccctgcag gactcagaag tcaatcaaga agctaagcca       60

gaggtcaagc cagaagtcaa gcctgagact cacatcaatt taaaggtgtc cgatggatct      120

tcagagatct tcttcaagat caaaaagacc actcctttaa gaaggctgat ggaagcgttc      180

gctaaaagac agggtaagga aatggactcc ttaacgttct tgtacgacgg tattgaaatt      240

caagctgatc agacccctga agatttggac atggaggata acgatattat tgaggctcac      300

cgcgaacaga ttggaggtga gcaagcgcca ggcaccgccc cctgctcccg cggcagctcc      360

tggagcgcgg acctggacaa gtgcatggac tgcgcgtctt gcagggcgcg accgcacagc      420

gacttctgcc tgggctgcgc tgcagcacct cctgccccct tctaa                      465


<210>  12
<211>  154
<212>  PRT
<213>  Homo sapiens

<220>
<223>  His-SUMO-hFn14

<400>  12

His His His His His His Gly Ser Leu Gln Asp Ser Glu Val Asn Gln 
1               5                   10                  15      


Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His Ile 
            20                  25                  30          


Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys 
        35                  40                  45              


Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg Gln 
    50                  55                  60                  


Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr Asp Gly Ile Glu Ile 
65                  70                  75                  80  


Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile 
                85                  90                  95      


Ile Glu Ala His Arg Glu Gln Ile Gly Gly Glu Gln Ala Pro Gly Thr 
            100                 105                 110         


Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys Cys 
        115                 120                 125             


Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys Leu 
    130                 135                 140                 


Gly Cys Ala Ala Ala Pro Pro Ala Pro Phe 
145                 150                 


<210>  13
<211>  918
<212>  DNA
<213>  Homo sapiens

<220>
<223>  human Fn14-GST

<400>  13
atggctcggg gctcgctgcg ccggttgctg cggctcctcg tgctggggct ctggctggcg       60

ttgctgcgct ccgtggccgg ggagcaagcg ccaggcaccg ccccctgctc ccgcggcagc      120

tcctggagcg cggacctgga caagtgcatg gactgcgcgt cttgcagggc gcgaccgcac      180

agcgacttct gcctgggctg cgctgcagca cctcctgccc ccttcggtac cctggaagtt      240

ctgttccagg ggcccatgtc ccctatacta ggttattgga aaattaaggg ccttgtgcaa      300

cccactcgac ttcttttgga atatcttgaa gaaaaatatg aagagcattt gtatgagcgc      360

gatgaaggtg ataaatggcg aaacaaaaag tttgaattgg gtttggagtt tcccaatctt      420

ccttattata ttgatggtga tgttaaatta acacagtcta tggccatcat acgttatata      480

gctgacaagc acaacatgtt gggtggttgt ccaaaagagc gtgcagagat ttcaatgctt      540

gaaggagcgg ttttggatat tagatacggt gtttcgagaa ttgcatatag taaagacttt      600

gaaactctca aagttgattt tcttagcaag ctacctgaaa tgctgaaaat gttcgaagat      660

cgtttatgtc ataaaacata tttaaatggt gatcatgtaa cccatcctga cttcatgttg      720

tatgacgctc ttgatgttgt tttatacatg gacccaatgt gcctggatgc gttcccaaaa      780

ttagtttgtt ttaaaaaacg tattgaagct atcccacaaa ttgataagta cttgaaatcc      840

agcaagtata tagcatggcc tttgcagggc tggcaagcca cgtttggtgg tggcgaccat      900

cctccaaaat cggattga                                                    918


<210>  14
<211>  305
<212>  PRT
<213>  Homo sapiens

<220>
<223>  human Fn14-GST

<400>  14

Met Ala Arg Gly Ser Leu Arg Arg Leu Leu Arg Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Trp Leu Ala Leu Leu Arg Ser Val Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala Pro Phe Gly Thr Leu Glu Val 
65                  70                  75                  80  


Leu Phe Gln Gly Pro Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys 
                85                  90                  95      


Gly Leu Val Gln Pro Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys 
            100                 105                 110         


Tyr Glu Glu His Leu Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn 
        115                 120                 125             


Lys Lys Phe Glu Leu Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile 
    130                 135                 140                 


Asp Gly Asp Val Lys Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile 
145                 150                 155                 160 


Ala Asp Lys His Asn Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu 
                165                 170                 175     


Ile Ser Met Leu Glu Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser 
            180                 185                 190         


Arg Ile Ala Tyr Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu 
        195                 200                 205             


Ser Lys Leu Pro Glu Met Leu Lys Met Phe Glu Asp Arg Leu Cys His 
    210                 215                 220                 


Lys Thr Tyr Leu Asn Gly Asp His Val Thr His Pro Asp Phe Met Leu 
225                 230                 235                 240 


Tyr Asp Ala Leu Asp Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp 
                245                 250                 255     


Ala Phe Pro Lys Leu Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro 
            260                 265                 270         


Gln Ile Asp Lys Tyr Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu 
        275                 280                 285             


Gln Gly Trp Gln Ala Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser 
    290                 295                 300                 


Asp 
305 


<210>  15
<211>  915
<212>  DNA
<213>  Macaca fascicularis

<220>
<223>  cyno Fn14-GST (Macaca fascicularis)

<400>  15
atggctcggg gctcgctgcg ccggttgctg cggctcctcg tgctggggct ctggctggcg       60

ttgctgcgct ccgtggccgg ggagcaagcg ccaggcaccg ccccctgctc ccacggcagc      120

tcctggagcg cggacctgga caagtgcatg gactgcgcgt cttgcagggc gcgaccgcac      180

agcgacttct gcctgggctg ctccgcagca cctcctgccc ccttcggtac cctggaagtt      240

ctgttccagg ggcccatgtc ccctatacta ggttattgga aaattaaggg ccttgtgcaa      300

cccactcgac ttcttttgga atatcttgaa gaaaaatatg aagagcattt gtatgagcgc      360

gatgaaggtg ataaatggcg aaacaaaaag tttgaattgg gtttggagtt tcccaatctt      420

ccttattata ttgatggtga tgttaaatta acacagtcta tggccatcat acgttatata      480

gctgacaagc acaacatgtt gggtggttgt ccaaaagagc gtgcagagat ttcaatgctt      540

gaaggagcgg ttttggatat tagatacggt gtttcgagaa ttgcatatag taaagacttt      600

gaaactctca aagttgattt tcttagcaag ctacctgaaa tgctgaaaat gttcgaagat      660

cgtttatgtc ataaaacata tttaaatggt gatcatgtaa cccatcctga cttcatgttg      720

tatgacgctc ttgatgttgt tttatacatg gacccaatgt gcctggatgc gttcccaaaa      780

ttagtttgtt ttaaaaaacg tattgaagct atcccacaaa ttgataagta cttgaaatcc      840

agcaagtata tagcatggcc tttgcagggc tggcaagcca cgtttggtgg tggcgaccat      900

cctccaaaat cggat                                                       915


<210>  16
<211>  305
<212>  PRT
<213>  Macaca fascicularis

<220>
<223>  cyno Fn14-GST (Macaca fascicularis)

<400>  16

Met Ala Arg Gly Ser Leu Arg Arg Leu Leu Arg Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Trp Leu Ala Leu Leu Arg Ser Val Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ala Pro Cys Ser His Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ser Ala Ala Pro Pro Ala Pro Phe Gly Thr Leu Glu Val 
65                  70                  75                  80  


Leu Phe Gln Gly Pro Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys 
                85                  90                  95      


Gly Leu Val Gln Pro Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys 
            100                 105                 110         


Tyr Glu Glu His Leu Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn 
        115                 120                 125             


Lys Lys Phe Glu Leu Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile 
    130                 135                 140                 


Asp Gly Asp Val Lys Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile 
145                 150                 155                 160 


Ala Asp Lys His Asn Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu 
                165                 170                 175     


Ile Ser Met Leu Glu Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser 
            180                 185                 190         


Arg Ile Ala Tyr Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu 
        195                 200                 205             


Ser Lys Leu Pro Glu Met Leu Lys Met Phe Glu Asp Arg Leu Cys His 
    210                 215                 220                 


Lys Thr Tyr Leu Asn Gly Asp His Val Thr His Pro Asp Phe Met Leu 
225                 230                 235                 240 


Tyr Asp Ala Leu Asp Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp 
                245                 250                 255     


Ala Phe Pro Lys Leu Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro 
            260                 265                 270         


Gln Ile Asp Lys Tyr Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu 
        275                 280                 285             


Gln Gly Trp Gln Ala Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser 
    290                 295                 300                 


Asp 
305 


<210>  17
<211>  918
<212>  DNA
<213>  Mouse

<220>
<223>  mouse Fn14-GST

<400>  17
atggcttcgg cttggccgcg gtctctgccg cagatcctcg tgttgggatt cggcttggtg       60

ttgatgcgcg ccgcggccgg ggagcaagca ccaggcacct ccccatgctc tagcggcagc      120

tcctggagcg cggacctcga caagtgcatg gactgcgctt cttgtccagc gcgaccacac      180

agcgacttct gcctgggatg cgccgcagca cctcctgccc acttcggtac cctggaagtt      240

ctgttccagg ggcccatgtc ccctatacta ggttattgga aaattaaggg ccttgtgcaa      300

cccactcgac ttcttttgga atatcttgaa gaaaaatatg aagagcattt gtatgagcgc      360

gatgaaggtg ataaatggcg aaacaaaaag tttgaattgg gtttggagtt tcccaatctt      420

ccttattata ttgatggtga tgttaaatta acacagtcta tggccatcat acgttatata      480

gctgacaagc acaacatgtt gggtggttgt ccaaaagagc gtgcagagat ttcaatgctt      540

gaaggagcgg ttttggatat tagatacggt gtttcgagaa ttgcatatag taaagacttt      600

gaaactctca aagttgattt tcttagcaag ctacctgaaa tgctgaaaat gttcgaagat      660

cgtttatgtc ataaaacata tttaaatggt gatcatgtaa cccatcctga cttcatgttg      720

tatgacgctc ttgatgttgt tttatacatg gacccaatgt gcctggatgc gttcccaaaa      780

ttagtttgtt ttaaaaaacg tattgaagct atcccacaaa ttgataagta cttgaaatcc      840

agcaagtata tagcatggcc tttgcagggc tggcaagcca cgtttggtgg tggcgaccat      900

cctccaaaat cggattga                                                    918


<210>  18
<211>  305
<212>  PRT
<213>  Mouse

<220>
<223>  mouse Fn14-GST

<400>  18

Met Ala Ser Ala Trp Pro Arg Ser Leu Pro Gln Ile Leu Val Leu Gly 
1               5                   10                  15      


Phe Gly Leu Val Leu Met Arg Ala Ala Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ser Pro Cys Ser Ser Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Pro Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala His Phe Gly Thr Leu Glu Val 
65                  70                  75                  80  


Leu Phe Gln Gly Pro Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys 
                85                  90                  95      


Gly Leu Val Gln Pro Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys 
            100                 105                 110         


Tyr Glu Glu His Leu Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn 
        115                 120                 125             


Lys Lys Phe Glu Leu Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile 
    130                 135                 140                 


Asp Gly Asp Val Lys Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile 
145                 150                 155                 160 


Ala Asp Lys His Asn Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu 
                165                 170                 175     


Ile Ser Met Leu Glu Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser 
            180                 185                 190         


Arg Ile Ala Tyr Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu 
        195                 200                 205             


Ser Lys Leu Pro Glu Met Leu Lys Met Phe Glu Asp Arg Leu Cys His 
    210                 215                 220                 


Lys Thr Tyr Leu Asn Gly Asp His Val Thr His Pro Asp Phe Met Leu 
225                 230                 235                 240 


Tyr Asp Ala Leu Asp Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp 
                245                 250                 255     


Ala Phe Pro Lys Leu Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro 
            260                 265                 270         


Gln Ile Asp Lys Tyr Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu 
        275                 280                 285             


Gln Gly Trp Gln Ala Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser 
    290                 295                 300                 


Asp 
305 


<210>  19
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GST

<400>  19
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660


<210>  20
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST

<400>  20

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp 
    210                 215                 220 


<210>  21
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-SUMO

<400>  21
catcatcacc accatcacgg gtccctgcag gactcagaag tcaatcaaga agctaagcca       60

gaggtcaagc cagaagtcaa gcctgagact cacatcaatt taaaggtgtc cgatggatct      120

tcagagatct tcttcaagat caaaaagacc actcctttaa gaaggctgat ggaagcgttc      180

gctaaaagac agggtaagga aatggactcc ttaacgttct tgtacgacgg tattgaaatt      240

caagctgatc agacccctga agatttggac atggaggata acgatattat tgaggctcac      300

cgcgaacaga ttggaggt                                                    318


<210>  22
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-SUMO

<400>  22

His His His His His His Gly Ser Leu Gln Asp Ser Glu Val Asn Gln 
1               5                   10                  15      


Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His Ile 
            20                  25                  30          


Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys 
        35                  40                  45              


Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg Gln 
    50                  55                  60                  


Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr Asp Gly Ile Glu Ile 
65                  70                  75                  80  


Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile 
                85                  90                  95      


Ile Glu Ala His Arg Glu Gln Ile Gly Gly 
            100                 105     


<210>  23
<211>  321
<212>  DNA
<213>  Mouse

<220>
<223>  mouse kappa constant

<400>  23
cgagctgatg ctgcaccaac tgtatccatc ttcccaccat ccagtgagca gttaacatct       60

ggaggtgcct cagtcgtgtg cttcttgaac aacttctacc ccaaagacat caatgtcaag      120

tggaagattg atggcagtga acgacaaaat ggcgtcctga acagttggac tgatcaggac      180

agcaaagaca gcacctacag catgagcagc accctcacgt tgaccaagga cgagtatgaa      240

cgacataaca gctatacctg tgaggccact cacaagacat caacttcacc catcgtcaag      300

agcttcaaca ggaatgagtg t                                                321


<210>  24
<211>  107
<212>  PRT
<213>  Mouse

<220>
<223>  mouse kappa constant

<400>  24

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210>  25
<211>  972
<212>  DNA
<213>  Mouse

<220>
<223>  mouse IgG1 (D265A) constant

<400>  25
gccaaaacga cacccccgtc tgtctatcca ctggcccctg gatctgctgc ccaaactaac       60

tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc      120

tggaactctg gctccctgtc cagcggtgtg cacaccttcc cagctgtcct ggagtctgac      180

ctctacactc tgagcagctc agtgactgtc ccctccagcc ctcggcccag cgagaccgtc      240

acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg      300

gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc      360

cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg      420

gtagccatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag      480

gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc      540

agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc      600

aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg      660

aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc      720

agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg      780

aatgggcagc cagcggagaa ctacaagaac actcagccca tcatgaacac gaatggctct      840

tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc      900

acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac      960

tctcctggta aa                                                          972


<210>  26
<211>  324
<212>  PRT
<213>  Mouse

<220>
<223>  mouse IgG1(D265A) constant

<400>  26

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Glu Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Ala Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asn Thr Asn Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  27
<211>  321
<212>  DNA
<213>  Homo sapiens

<220>
<223>  human kappa constant

<400>  27
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  28
<211>  107
<212>  PRT
<213>  Homo sapiens

<220>
<223>  human kappa constant

<400>  28

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  29
<211>  981
<212>  DNA
<213>  Homo sapiens

<220>
<223>  human IgG4 null constant

<400>  29
gctagcacca aggggccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcacctgagt tcgagggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaagcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  30
<211>  327
<212>  PRT
<213>  Homo sapiens

<220>
<223>  human IgG4 null constant

<400>  30

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  31
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41C-VH (with signal peptide) (not codon optimized)

<400>  31
atgggatgga gctggatctt tctctttctc ctgtcagaaa ctgcaggtgt cctctctgag       60

gtccagctgc aacagtctgg acctgagctg gtgaagcctg gggcttcagt gaagatgtcc      120

tgcaaggctt ctggatacac attcactgac tacaacatgc actgggtgaa gcagagccat      180

ggaaagagcc ttgaatggat tggatatatt aaccctaaca atggtggtac taactacaac      240

cagaagttca agggcaaggc cacattgact gtaaacaagt cctccaggtc agcctacatg      300

gagttccgca gcctgacatc ggaggattct gcagtctatt actgtgcctc gtcgggatgg      360

tttacttact ggggccaagg gactctggtc actgtctctg ca                         402


<210>  32
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41C-VH (with signal peptide) (not codon optimized)

<400>  32

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Glu Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg 
                85                  90                  95      


Ser Ala Tyr Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala 
    130                 


<210>  33
<211>  360
<212>  DNA
<213>  Mouse

<220>
<223>  41C-VH (no signal peptide) (not codon optimized)

<400>  33
gaggtccagc tgctccagtc tggacctgag ctggtgaagc ctgtggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca ttcactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat attaacccta acaatggtgt tactggctac      180

aaccagaagt tcaggggcaa ggccacattg actgttaaca ggtcctccaa cacagcctac      240

atggacctcc gcagcctgac atcggaggat tctgcagtct attactgtac aagacgctat      300

ggtgactacg tccatgctat ggactgctgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  34
<211>  345
<212>  DNA
<213>  Mouse

<220>
<223>  41C-VH (no signal peptide) [codon optimized]

<400>  34
gaagtgcagc tgcagcagtc tggccccgag ctcgtgaaac ctggcgcctc cgtgaagatg       60

tcctgcaagg cctccggcta caccttcacc gactacaaca tgcactgggt caagcagtcc      120

cacggcaagt ccctggaatg gatcggctac atcaacccca acaacggcgg caccaactac      180

aaccagaagt tcaagggcaa ggctaccctg accgtgaaca agtcctccag atccgcctac      240

atggaatttc ggtccctgac ctccgaggac tccgccgtgt actactgcgc ctcctctggc      300

tggttcacct actggggcca gggcaccctc gtgaccgtgt ctgct                      345


<210>  35
<211>  115
<212>  PRT
<213>  Mouse

<220>
<223>  41C-VH (no signal peptide)

<400>  35

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  36
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41C-VL (with signal peptide) (not codon optimized)

<400>  36
atgatgagtc ctgcccagtt cctgtttctg ttagtgctct ggattcggga aaccaacggt       60

gatgttgtga tgacccagac tccactcact ttgtcggttg ccattggaca accagcctcc      120

atctcttgca agtcaagtca gagcctctta aatagtgctg gaaagacata tttgaattgg      180

ttgttacaga ggccaggcca gtctccaaag cgcctaattt atctggtgtc tcaactggac      240

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      300

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg      360

tggacgttcg gtggaggcac caagctggaa atcaaa                                396


<210>  37
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41C-VL (with signal peptide) (not codon optimized)

<400>  37

Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg 
1               5                   10                  15      


Glu Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
            20                  25                  30          


Val Ala Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Ala Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Trp Gln Gly Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  38
<211>  336
<212>  DNA
<213>  Mouse

<220>
<223>  41C-VL (no signal peptide) (not codon optimized)

<400>  38
gatgttgtga tgacccagac tccactcact ttgtcggttg ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta aatagtgctg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaattt atctggtgtc tcaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  39
<211>  336
<212>  DNA
<213>  Mouse

<220>
<223>  41C-VL (no signal peptide) (codon optimized)

<400>  39
gacgtcgtga tgacccagac ccccctgaca ctgtctgtgg ccatcggcca gcctgcctcc       60

atctcctgca agtcctccca gtccctgctg aactccgccg gcaagaccta cctgaactgg      120

ctgctgcagc ggcctggcca gtcccccaag agactgatct acctggtgtc ccagctggac      180

tccggcgtgc ccgatagatt caccggctct ggctctggca ccgacttcac cctgaagatc      240

agccgggtgg aagccgagga cctgggcgtg tactactgct ggcagggcac ccacttccct      300

tggacctttg gcggaggcac caagctggaa atcaag                                336


<210>  40
<211>  112
<212>  PRT
<213>  Mouse

<220>
<223>  41C-VL (no signal peptide)

<400>  40

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  41
<211>  417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  42d-VH (with signal peptide)

<400>  41
atgggatgga gctggatctt tctctttctc ctgtcagaaa ctgcaggtgt cctctctgag       60

gtccagctgc tccagtctgg acctgagctg gtgaagcctg tggcttcagt gaagatgtcc      120

tgcaaggctt ctggatacac attcactgac tacaacattc actgggtgaa gcagagccat      180

ggaaagagcc ttgagtggat tggatatatt aaccctaaca atggtgttac tggctacaac      240

cagaagttca ggggcaaggc cacattgact gttaacaggt cctccaacac agcctacatg      300

gacctccgca gcctgacatc ggaggattct gcagtctatt actgtacaag acgctatggt      360

gactacgtcc atgctatgga ctgctggggt caaggaacct cagtcaccgt ctcctca         417


<210>  42
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  42d-VH (with signal peptide)

<400>  42

Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Glu Thr Ala Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Val Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Asn Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Asn Asn Gly Val Thr Gly Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asn Arg Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Arg Tyr Gly Asp Tyr Val His Ala Met Asp Cys 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 


<210>  43
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  42d-VH (no signal peptide)

<400>  43
gaggtccagc tgctccagtc tggacctgag ctggtgaagc ctgtggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca ttcactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat attaacccta acaatggtgt tactggctac      180

aaccagaagt tcaggggcaa ggccacattg actgttaaca ggtcctccaa cacagcctac      240

atggacctcc gcagcctgac atcggaggat tctgcagtct attactgtac aagacgctat      300

ggtgactacg tccatgctat ggactgctgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  44
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  42d-VH (no signal peptide)

<400>  44

Glu Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Val Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Val Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asn Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Tyr Gly Asp Tyr Val His Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  45
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  42d-VL (with signal peptide)

<400>  45
atggacatga gggctcctgc acagattttt ggcttcttgt tgctcttgtt tccaggtacc       60

agatgtgaca tccagatgac ccagtctcca tcctccttat ctgcctctct gggagaaaga      120

gtcagtctca cttgtcgggc aagtcaggac attggtagta ggttaaactg gcttcagcag      180

gaaccagatg gaactattaa acgcctgatc tacgccacat ccagtttaga ttctggtgtc      240

cccaaaaggt tcagtggcag taggtctggg tcagattatt ctctcaccat cagcagcctt      300

gagtctgaag attttgtaga ctattactgt ctacaatatg ctagttctcc gtacacattc      360

ggagggggga ccaagctgga aataaaa                                          387


<210>  46
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  42d-VL (with signal peptide)

<400>  46

Met Asp Met Arg Ala Pro Ala Gln Ile Phe Gly Phe Leu Leu Leu Leu 
1               5                   10                  15      


Phe Pro Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Gly Ser Arg Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly 
    50                  55                  60                  


Thr Ile Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Ser Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Ala Ser Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys 
    


<210>  47
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  42d-VL (no signal peptide)

<400>  47
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggacattggt agtaggttaa actggcttca gcaggaacca      120

gatggaacta ttaaacgcct gatctacgcc acatccagtt tagattctgg tgtccccaaa      180

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct      240

gaagattttg tagactatta ctgtctacaa tatgctagtt ctccgtacac attcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  48
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  42d-VL (no signal peptide)

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Arg 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  49
<211>  345
<212>  DNA
<213>  Mouse

<220>
<223>  R35B9-VH

<400>  49
gaggtgcagc tgcagcaaag cggcccggag ctggtgaaac cgggtgcgag cgttaaaatg       60

agctgcaagg cgagcggtta catttttcag gattataata tgcattgggt taaacagagc      120

cacggtaaaa gcctggagtg gatcggctct attaatccgc gtaatggttg gaccaactat      180

aaccaaaagt tcaaaggcaa ggcgaccctg accgtgaaca agagcagccg tagcgcgtac      240

atggagtttc gtagcctgac cagcgaagat agcgcggttt actattgcgc gtcttcgggg      300

tggttcacgt attggggtca aggcaccctg gtgaccgtta gcgcg                      345


<210>  50
<211>  115
<212>  PRT
<213>  Mouse

<220>
<223>  R35B9-VH

<400>  50

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  51
<211>  336
<212>  DNA
<213>  Mouse

<220>
<223>  R35B9-VL

<400>  51
gacgtggtta tgacccaaac cccgctgacc ctgagcgtgg cgattggtca gccggcgagc       60

attagctgca agagcagcca aagcctgctg aacagcgcgg gtaaaaccta cctgaactgg      120

ctgctgcagc gtccgggtca aagcccgaag cgtctgatct atctggtgag ccagctggac      180

agcggtgtgc cggaccgttt caccggtagc ggtagcggca ccgactttac cctgaaaatt      240

agccgtgtgg aggcggaaga tctgggtgtt tactattgct ggcaaggtac tttttatccg      300

tggacctttg gtggcggtac caagctggag atcaaa                                336


<210>  52
<211>  112
<212>  PRT
<213>  Mouse

<220>
<223>  R35B9-VL

<400>  52

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  53
<211>  345
<212>  DNA
<213>  Mouse

<220>
<223>  R35B9(Y50G57)-VH

<400>  53
gaggtgcagc tgcagcaaag cggcccggag ctggtgaaac cgggtgcgag cgttaaaatg       60

agctgcaagg cgagcggtta catttttcag gattataata tgcattgggt taaacagagc      120

cacggtaaaa gcctggagtg gatcggctat attaatccgc gtaatggtgg gaccaactat      180

aaccaaaagt tcaaaggcaa ggcgaccctg accgtgaaca agagcagccg tagcgcgtac      240

atggagtttc gtagcctgac cagcgaagat agcgcggttt actattgcgc gtcttcgggg      300

tggttcacgt attggggtca aggcaccctg gtgaccgtta gcgcg                      345


<210>  54
<211>  115
<212>  PRT
<213>  Mouse

<220>
<223>  R35B9(Y50G57)-VH

<400>  54

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  55
<211>  345
<212>  DNA
<213>  Mouse

<220>
<223>  R35B9(Y50A56G57)-VH

<400>  55
gaggtgcagc tgcagcaaag cggcccggag ctggtgaaac cgggtgcgag cgttaaaatg       60

agctgcaagg cgagcggtta catttttcag gattataata tgcattgggt taaacagagc      120

cacggtaaaa gcctggagtg gatcggctat attaatccgc gtaatgccgg gaccaactat      180

aaccaaaagt tcaaaggcaa ggcgaccctg accgtgaaca agagcagccg tagcgcgtac      240

atggagtttc gtagcctgac cagcgaagat agcgcggttt actattgcgc gtcttcgggg      300

tggttcacgt attggggtca aggcaccctg gtgaccgtta gcgcg                      345


<210>  56
<211>  115
<212>  PRT
<213>  Mouse

<220>
<223>  R35B9(Y50A56G57)-VH

<400>  56

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Ala Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  57
<211>  336
<212>  DNA
<213>  Mouse

<220>
<223>  R35B9(H98)-VL

<400>  57
gacgtggtta tgacccaaac cccgctgacc ctgagcgtgg cgattggtca gccggcgagc       60

attagctgca agagcagcca aagcctgctg aacagcgcgg gtaaaaccta cctgaactgg      120

ctgctgcagc gtccgggtca aagcccgaag cgtctgatct atctggtgag ccagctggac      180

agcggtgtgc cggaccgttt caccggtagc ggtagcggca ccgactttac cctgaaaatt      240

agccgtgtgg aggcggaaga tctgggtgtt tactattgct ggcaaggtac tcattatccg      300

tggacctttg gtggcggtac caagctggag atcaaa                                336


<210>  58
<211>  112
<212>  PRT
<213>  Mouse

<220>
<223>  R35B9(H98)-VL

<400>  58

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  59
<211>  345
<212>  DNA
<213>  Mouse

<220>
<223>  R35B9(A56)-VH

<400>  59
gaggtgcagc tgcagcaaag cggcccggag ctggtgaaac cgggtgcgag cgttaaaatg       60

agctgcaagg cgagcggtta catttttcag gattataata tgcattgggt taaacagagc      120

cacggtaaaa gcctggagtg gatcggctct attaatccgc gtaatgcttg gaccaactat      180

aaccaaaagt tcaaaggcaa ggcgaccctg accgtgaaca agagcagccg tagcgcgtac      240

atggagtttc gtagcctgac cagcgaagat agcgcggttt actattgcgc gtcttcgggg      300

tggttcacgt attggggtca aggcaccctg gtgaccgtta gcgcg                      345


<210>  60
<211>  115
<212>  PRT
<213>  Mouse

<220>
<223>  R35B9(A56)-VH

<400>  60

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  61
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRCBT-06-002_VH (no signal peptide)

<400>  61
gaagtgaagc tgcagcagag cggcggagga ctggtgcagc ctggcggatc tatgaagctg       60

agctgtgtgg ccagcggctt caccttcagc tactactgga tgaactgggt gcgccagagc      120

cccgagcagg gcctggaatg gatcgccgaa atcagactgc agagcaacga ctaccccacc      180

cactacgccg agagcgtgaa gggcagattc accatcagcc gggacgacag caagaacagc      240

gtgtacctgc agatgaacaa cctgcggccc gaggacaccg gcatctacta ctgcgcctgc      300

agatacgccg actacttcga ccactggggc cagggcacaa ccctgaccgt gtcatct         357


<210>  62
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRCBT-06-002_VH (no signal peptide)

<400>  62

Glu Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Glu Ile Arg Leu Gln Ser Asn Asp Tyr Pro Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Pro Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Cys Arg Tyr Ala Asp Tyr Phe Asp His Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  63
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRCBT-06-002_VL (no signal peptide)

<400>  63
gacaccgtgc tgacccagag ccctgcttct ctggtggtgt ccctgggcca gagagccacc       60

atcagctgta gagccagcca gagcgtgtcc accagcgact acagctacat ccactggtat      120

cagcagaagc ccggccagcc ccccaagttc ctgattaagt acgccagcaa ccgggacagc      180

ggcgtgcccg ccagattttc tggcagcggc tctggcaccg acttcaccct gaacatccac      240

cccgtggaag aggacgatac cgccatctac tactgccagc acagctggga gatccccccc      300

acatttggag ccggcaccaa gctggaactg cag                                   333


<210>  64
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRCBT-06-002_VL (no signal peptide)

<400>  64

Asp Thr Val Leu Thr Gln Ser Pro Ala Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Asp Tyr Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Phe Leu Ile Lys Tyr Ala Ser Asn Arg Asp Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Thr Ala Ile Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Gln 
            100                 105                 110     


<210>  65
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV5a

<400>  65
caagtgcaac tggtgcaaag cggagctgaa gtaaagaagc ctggagcatc cgtcaaggta       60

agttgcaagg ctagtggcta tatcttccag gactataata tgcattgggt acgccaggct      120

cccggacaag ggctggagtg gatagggagc atcaatccac gcaacggatg gaccaactac      180

aatcagaagt tcaaaggacg agcaactatc actgcagata catcaacctc cactgcttac      240

atggaattga gttccctgcg ttccgaagac accgcagtgt actattgtgc cagttcaggg      300

tggtttactt actggggaca aggcacactg gtgaccgttt ctagc                      345


<210>  66
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV5a

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  67
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV5b

<400>  67
caagttcagc ttgtccagag cggtgctgaa gtggtcaaac caggcgcaag tgttaaagtt       60

tcttgcaagg catctggata tatttttcag gactacaaca tgcactgggt acgacaagcc      120

cacggtcagg gattggaatg gatgggatcc atcaacccaa gaaacggttg gacaaattac      180

aatcaaaagt tcaaaggcag ggtaacaatc accgcagaca caagcaccag taccgcttac      240

atggagctga gctctttgag atcagaggac actgctgtgt actattgcgc atctagcggg      300

tggttcactt actggggaca gggcactctt gtgactgtga gctct                      345


<210>  68
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV5b

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  69
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV6a

<400>  69
caagttcaac ttgttcaatc aggcgcagaa gtagtgaaac ctggtgcttc tgtgaaggtg       60

tcatgtaagg ccagcggtta tatctttcag gactacaata tgcattgggt tcgccaagca      120

catgggcagt ccctggagtg gatggggtct atcaatcctc gcaatggctg gaccaactat      180

aaccaaaagt tcaagggtag ggtcactatc actgctgaca catccacctc taccgcctac      240

atggaattgt catctttgcg ctctgaggac actgctgtgt actattgcgc ttcatcaggc      300

tggttcacct attggggaca gggcacattg gtgactgtgt cttcc                      345


<210>  70
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV6a

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  71
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV6b

<400>  71
caagtccaac tggtgcaaag cggagctgaa gtgaagaagc caggtgccag tgtcaaggta       60

tcctgcaagg caagtggtta tattttccag gactataata tgcattgggt taggcaggca      120

catggacagg ggctcgaatg gatcgggagt attaacccac gtaatgggtg gactaattac      180

aaccagaagt tcaaaggaag ggccaccatt acagccgaca aatcaacctc aactgcttat      240

atggagctta gcagcctgcg ttctgaggac actgctgtat actattgtgc ccgttcaggt      300

tggttcacct actggggaca gggcactctt gttacagtca gttct                      345


<210>  72
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV6b

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  73
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV6c

<400>  73
caggtacagc tcgttcaaag cggtgccgag gtaaaaaagc ctggggcctc tgttaaagtt       60

tcatgcaagg cctcaggata tatctttcaa gactacaaca tgcattgggt gcgtcaggca      120

catggccagg gcctcgaatg gatcggcagc ataaatccac ggaacggttg gaccaactac      180

aaccagaaat tcaaaggaag ggccactata accgccgaca catctacttc taccgcatac      240

atggaactct ccagtctcag gtcagaagat acagccgtct actattgcgc cagtagcggt      300

tggtttacat actgggggca aggaactctc gttaccgtgt ccagc                      345


<210>  74
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV6c

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  75
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV7a

<400>  75
caggtacaac tggtacagtc tggagctgag gtggttaagc caggggccag cgtcaaagta       60

tcctgtaagg cttccggata tatattccag gactacaata tgcactgggt tcggcaagcc      120

cacggacaat ctctggagtg gatgggctcc atcaatccca ggaatggatg gaccaattac      180

aatcagaagt tcaaggggcg agtcacaatc acagctgata caagtactag aaccgcttac      240

atggagcttt cttcattgag gtccgaggat acagctgtct actactgcgc ttcctcagga      300

tggtttactt attggggtca aggaactctg gtgacagtta gcagc                      345


<210>  76
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV7a

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  77
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV7b

<400>  77
caagtgcagc tcgttcagtc tggagccgag gtagtcaagc ccggcgcatc tgttaaagtc       60

agttgcaaag cttccggcta tatcttccag gattacaaca tgcactgggt cagacaggct      120

cacggtcaag ggctcgaatg gatgggaagt attaaccctc gtaatggatg gactaactat      180

aaccaaaagt ttaaggggag ggtgactatt acagcagata agtctactcg cactgcctat      240

atggagctta gctcactccg ctccgaagac accgctgtgt attactgtgc tagttccggg      300

tggttcacct attgggggca aggaactctt gtaacagttt cctct                      345


<210>  78
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV7b

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  79
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV7c

<400>  79
caagttcaac tggtgcagtc tggcgctgag gtaaaaaaac ccggcgcctc tgttaaagta       60

agttgtaaag catctgggta tatctttcaa gattacaaca tgcactgggt taagcaggct      120

cccggacagg gtcttgagtg gatagggtcc ataaatcccc gcaatggctg gactaattat      180

aaccaaaagt tcaaaggaaa agccaccatc acagcagaca ccagtacatc taccgcctac      240

atggaattga gttctctgcg gagcgaggat accgcagtct attactgcgc ctcatctgga      300

tggtttactt actggggtca gggcactctg gtgactgttt caagt                      345


<210>  80
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV7c

<400>  80

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  81
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV9a

<400>  81
caagttcagc tcgtgcagtc tggagcagag gtaaagaaac ccggcgcatc agtgaagatg       60

agttgtaagg ctagtggtta tatattccag gattataata tgcactgggt acgacaggct      120

ccaggccaag ggcttgaatg gataggcagc attaaccccc gaaacggctg gactaattac      180

aaccagaaat tcaagggacg cgcaaccctc actgtggata cttccacatc tactgcttac      240

atggagtttt catcactcag gtcagaagac acagcagtgt actactgtgc ctcctctggg      300

tggttcacat attggggaca aggcacattg gtgacagtct cctct                      345


<210>  82
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV9a

<400>  82

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  83
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV9b

<400>  83
caggtccaac tggtacagtc cggcgctgaa gtaaaaaaac caggcgctag tgtcaaggta       60

tcatgcaaag caagtgggta tatctttcag gattataata tgcactgggt aaaacaggct      120

cacggccaat ccctggagtg gatcggttcc atcaatccac ggaacggctg gaccaactac      180

aaccagaagt ttaagggccg tgctaccatt acagccgaca ctagcactag cacagcttac      240

atggaattct cctccctgcg aagcgaagac accgcagtgt attactgcgc tagttccggt      300

tggttcactt actggggcca gggcacactc gtcactgtct caagc                      345


<210>  84
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV9b

<400>  84

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala His Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  85
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV10

<400>  85
caggtgcaac tggtgcaatc tggggcagaa gttaaaaaac caggcgctag cgtaaaagtt       60

tcttgcaaag caagtgggta catattccaa gattacaata tgcattgggt caggcaggcc      120

cacggtcagg gattggagtg gatcggctct atcaacccta gaaatggttg gactaactac      180

aaccagaagt tcaaaggaaa agccaccatt accgccgata aatccaccag gacagcctat      240

atggagtttt ctagccttcg tagcgaagac accgctgtgt attattgcgc ttctagtgga      300

tggttcactt attggggtca ggggaccttg gtcactgtta gttct                      345


<210>  86
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV10

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  87
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV11

<400>  87
caagttcaac ttgtccaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt tagacaggca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacggatg gacaaattac      180

aaccaaaagt tcaaagggag agctactatc actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  88
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV11

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  89
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV18

<400>  89
gaggtccaac tggttcaaag tggaccagag gtggtgaaac caggagctag cgtaaaaatg       60

agctgtaagg cttcaggtta tatctttcag gattacaaca tgcactgggt aaaacaagcc      120

cacggccagt ctctcgaatg gattgggtca atcaatcccc gaaacggttg gacaaactat      180

aatcagaaat tcaaaggtaa agcaacattg actgttgaca aatcaaccag gaccgcatac      240

atggagtttt catccctgcg tagtgaagac actgctgttt actactgtgc tagttctggg      300

tggttcactt actgggggca gggaactctt gtcactgttt cttca                      345


<210>  90
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV18

<400>  90

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala His Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  91
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV0

<400>  91
gacgtagtga tgactcagag ccctctgtca ctccccgtca cactgggaca accagcttcc       60

atctcctgca agtcatctca atctttgttg aatagcgcag gaaagacata cctgaactgg      120

ttccaacaac gccctggtca aagcccacgc aggctgatct atttggtaag tcaactggat      180

agcggagtac ctgaccgttt ctctggaagt ggaagtggta ctgacttcac cttgaaaatc      240

tccagggttg aagccgagga cgtgggggtg tattactgtt ggcaaggtac tttctaccct      300

tggactttcg gcggcggtac caaggtagag attaaa                                336


<210>  92
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV0

<400>  92

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  93
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV1a

<400>  93
gatgtagtaa tgacccagtc cccacttagc ttgcccgtta cactcggcca acccgcaagc       60

atatcttgca aatccagtca gagcctcctg aactctgctg gaaagaccta tctgaattgg      120

cttcaacaac gtcccggtca atcccccaga cgacttatct acttggtaag tcagcttgac      180

tccggggttc cagacaggtt ttccggatct ggaagtggaa ctgattttac actcaaaatt      240

agtcgagtcg aggccgaaga cgtgggtgtc tattattgct ggcaaggcac cttttatcca      300

tggacttttg gtgggggcac caaggttgaa attaag                                336


<210>  94
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV1a

<400>  94

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  95
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV1b

<400>  95
gatgttgtga tgacacaaag tcctctgagc cttccagtca cattgggtca gcctgcatct       60

attagttgta agagcagtca atcactgctg aatagtgccg gaaaaacata cttgaattgg      120

ttccttcagc gcccaggcca gtctcctcgg cggttgattt atcttgtgtc tcaactggat      180

tctggtgtcc ccgatagatt ttcaggttca gggtcaggga ccgattttac actgaagatt      240

tctcgcgtcg aggcagagga cgttggggtt tattactgtt ggcagggaac attttatcca      300

tggacattcg ggggaggaac caaggtagag attaaa                                336


<210>  96
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV1b

<400>  96

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  97
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV3a

<400>  97
gacgtagtta tgactcagtc tccactctct ctccccgtga ccattggaca gcctgcatca       60

atatcctgca aaagtagcca gtccttgctc aactcagccg gtaaaaccta cctcaactgg      120

ttccttcagc gccccggtca gtctccaaag cgtttgatat acctggtgag tcaactcgac      180

tcaggtgtcc ccgatcgctt ctctgggagc ggttcaggca cagattttac tctcaaaata      240

tccagagttg aagctgaaga cgttggggtt tactattgct ggcagggaac attctatcct      300

tggacttttg gaggaggcac aaaggttgag atcaag                                336


<210>  98
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV3a

<400>  98

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  99
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV3b

<400>  99
gacgttgtaa tgacccaaag tccactgtca cttcccgtaa ccatagggca acccgccagc       60

atctcctgca aatcatccca aagtcttctt aacagtgccg gaaaaacata cttgaactgg      120

ctcttgcaga ggccagggca atctcctcga cgactgatat accttgtatc ccagttggat      180

tctggcgtgc ccgacagatt cagtggaagc ggatctggca cagactttac ccttaaaatc      240

agccgcgtgg aggccgagga tgttggagtg tactactgtt ggcaaggaac attttaccct      300

tggacctttg gcggggggac caaagtcgag ataaag                                336


<210>  100
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV3b

<400>  100

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  101
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV4

<400>  101
gatgtcgtga tgacacaaag tcccctgagc ttgcccgtaa ctattgggca accagcctct       60

atctcttgta aatcatcaca atctttgctc aattctgctg gcaagacata ccttaactgg      120

cttttgcaac gccctggtca aagccctaag agattgattt atctcgtcag ccagctggac      180

tctggggtcc cagatcgctt tagtgggtca ggctctggaa ccgacttcac actgaagatc      240

tccagggttg aagccgagga tgtaggggtt tattactgtt ggcaaggcac cttttatccc      300

tggacttttg ggggcggcac caaggtcgaa ataaag                                336


<210>  102
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV4

<400>  102

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  103
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV5

<400>  103
gatgttgtca tgactcaatc accattgagc ctccccgtga caataggcca gcctgcttcc       60

atttcctgta agtcaagcca gagtctgctt aatagtgccg ggaagaccta tctgaactgg      120

ctcttgcaga gaccaggaca atctccaaaa cggttgatct acctggtcag ccagttggac      180

agcggcgttc cagatcgatt cagtggcagt ggatctggaa ctgattttac cttgaagatt      240

agtagagtag aggcagagga cgtgggagta tattactgct ggcagggaac cttctacccc      300

tggacctttg gcggcggcac caagctcgag atcaaa                                336


<210>  104
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VL_LV5

<400>  104

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  105
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-VH_HV7c

<400>  105
caagttcaac tggtgcagtc tggcgctgag gtaaaaaaac ccggcgcctc tgttaaagta       60

agttgtaaag catctgggta tatctttcaa gattacaaca tgcactgggt taagcaggct      120

cccggacagg gtcttgagtg gatagggtcc ataaatcccc gcaatgcctg gactaattat      180

aaccaaaagt tcaaaggaaa agccaccatc acagcagaca ccagtacatc taccgcctac      240

atggaattga gttctctgcg gagcgaggat accgcagtct attactgcgc ctcatctgga      300

tggtttactt actggggtca gggcactctg gtgactgttt caagt                      345


<210>  106
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-VH_HV7c

<400>  106

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  107
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-VH_HV11

<400>  107
caagttcaac ttgtccaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt tagacaggca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcaaagggag agctactatc actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  108
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-VH_HV11

<400>  108

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  109
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(Y50A56G57)-VH_HV7b

<400>  109
caagtgcagc tcgttcagtc tggagccgag gtagtcaagc ccggcgcatc tgttaaagtc       60

agttgcaaag cttccggcta tatcttccag gattacaaca tgcactgggt cagacaggct      120

cacggtcaag ggctcgaatg gatgggatat attaaccctc gtaatgccgg gactaactat      180

aaccaaaagt ttaaggggag ggtgactatt acagcagata agtctactcg cactgcctat      240

atggagctta gctcactccg ctccgaagac accgctgtgt attactgtgc tagttccggg      300

tggttcacct attgggggca aggaactctt gtaacagttt cctct                      345


<210>  110
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(Y50A56G57)-VH_HV7b

<400>  110

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Ala Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  111
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(H98)-VL_LV1a

<400>  111
gatgtagtaa tgacccagtc cccacttagc ttgcccgtta cactcggcca acccgcaagc       60

atatcttgca aatccagtca gagcctcctg aactctgctg gaaagaccta tctgaattgg      120

cttcaacaac gtcccggtca atcccccaga cgacttatct acttggtaag tcagcttgac      180

tccggggttc cagacaggtt ttccggatct ggaagtggaa ctgattttac actcaaaatt      240

agtcgagtcg aggccgaaga cgtgggtgtc tattattgct ggcaaggcac ccattatcca      300

tggacttttg gtgggggcac caaggttgaa attaag                                336


<210>  112
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(H98)-VL_LV1a

<400>  112

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  113
<211>  10
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR1 42d

<400>  113

Gly Tyr Thr Phe Thr Asp Tyr Asn Ile His 
1               5                   10  


<210>  114
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR2 42d

<400>  114

Tyr Ile Asn Pro Asn Asn Gly Val Thr Gly Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  11
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR3 42d

<400>  115

Arg Tyr Gly Asp Tyr Val His Ala Met Asp Cys 
1               5                   10      


<210>  116
<211>  11
<212>  PRT
<213>  Mouse

<220>
<223>  LCDR1 42d

<400>  116

Arg Ala Ser Gln Asp Ile Gly Ser Arg Leu Asn 
1               5                   10      


<210>  117
<211>  7
<212>  PRT
<213>  Mouse

<220>
<223>  LCDR2 42d

<400>  117

Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210>  118
<211>  9
<212>  PRT
<213>  Mouse

<220>
<223>  LCDR3 42d

<400>  118

Leu Gln Tyr Ala Ser Ser Pro Tyr Thr 
1               5                   


<210>  119
<211>  10
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR1 41c

<400>  119

Gly Tyr Thr Phe Thr Asp Tyr Asn Met His 
1               5                   10  


<210>  120
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR2 41c

<400>  120

Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  121
<211>  6
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR3 all 41c and R35B9-related antibodies

<400>  121

Ser Gly Trp Phe Thr Tyr 
1               5       


<210>  122
<211>  10
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR1 R35B9

<400>  122

Gly Tyr Ile Phe Gln Asp Tyr Asn Met His 
1               5                   10  


<210>  123
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR2 R35B9

<400>  123

Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  124
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR2 R35B9(A56)

<400>  124

Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  125
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR2 R35B9(Y50G57)

<400>  125

Tyr Ile Asn Pro Arg Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR2 R35B9(Y50A56G57)

<400>  126

Tyr Ile Asn Pro Arg Asn Ala Gly Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  16
<212>  PRT
<213>  Mouse

<220>
<223>  LCDR1 all 41c and R35B9-related antibodies

<400>  127

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ala Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  128
<211>  7
<212>  PRT
<213>  Mouse

<220>
<223>  LCDR2 all 41c and R35B9-related antibodies

<400>  128

Leu Val Ser Gln Leu Asp Ser 
1               5           


<210>  129
<211>  9
<212>  PRT
<213>  Mouse

<220>
<223>  LCDR3 41C

<400>  129

Trp Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  130
<211>  9
<212>  PRT
<213>  Mouse

<220>
<223>  LCDR3 R35B9 mouse and humanized

<400>  130

Trp Gln Gly Thr Phe Tyr Pro Trp Thr 
1               5                   


<210>  131
<211>  9
<212>  PRT
<213>  Mouse

<220>
<223>  LCDR3 R35B9(H98)

<400>  131

Trp Gln Gly Thr His Tyr Pro Trp Thr 
1               5                   


<210>  132
<211>  25
<212>  PRT
<213>  Mouse

<220>
<223>  H-FR1 mouse R35B9 and 41c

<400>  132

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  133
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR1 humanized HV0, HV5a,HV6b, HV6c, HV7c, HV9b, HV10

<400>  133

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  134
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR1 humanized HV5b, HV6a, HV7a, HV7b

<400>  134

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  135
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR1 humanized HV9a

<400>  135

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  136
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR1 humanized HV11

<400>  136

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  137
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR1 humanized HV18

<400>  137

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  138
<211>  14
<212>  PRT
<213>  Mouse

<220>
<223>  H-FR2 mouse R35B9 and 41c

<400>  138

Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  139
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV5a, HV9a

<400>  139

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  140
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV5b, HV7b

<400>  140

Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  141
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV6a, HV7a, HV11

<400>  141

Trp Val Arg Gln Ala His Gly Gln Ser Leu Glu Trp Met Gly 
1               5                   10                  


<210>  142
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV6b, HV6c, HV10

<400>  142

Trp Val Arg Gln Ala His Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  143
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV7c

<400>  143

Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  144
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV9b, HV18

<400>  144

Trp Val Lys Gln Ala His Gly Gln Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  145
<211>  32
<212>  PRT
<213>  Mouse

<220>
<223>  H-FR3 mouse R35B9 and 41c

<400>  145

Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr Met Glu 
1               5                   10                  15      


Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  146
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV5a, HV6c

<400>  146

Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  147
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV5b, HV6a

<400>  147

Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  148
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV6b

<400>  148

Arg Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  149
<211>  17
<212>  PRT
<213>  Mouse

<220>
<223>  HCDR2 R35B9(Y50)

<400>  149

Tyr Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  150
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV7a

<400>  150

Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Arg Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  151
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV7b

<400>  151

Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Arg Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  152
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV7c

<400>  152

Lys Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  153
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV9a

<400>  153

Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  154
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV9b

<400>  154

Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  155
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV10

<400>  155

Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Arg Thr Ala Tyr Met Glu 
1               5                   10                  15      


Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  156
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV11

<400>  156

Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  157
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV18

<400>  157

Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr Met Glu 
1               5                   10                  15      


Phe Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  158
<211>  11
<212>  PRT
<213>  Mouse

<220>
<223>  H-FR4 mouse R35B9 and 41c

<400>  158

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  159
<211>  11
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR4 humanized (all)

<400>  159

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  160
<211>  23
<212>  PRT
<213>  Mouse

<220>
<223>  L-FR1 mouse R35B9 and 41c

<400>  160

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  161
<211>  23
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR1 human LV0, LV1a, LV1b

<400>  161

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  162
<211>  23
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR1 humanized LV3a, LV3b, LV4, LV5

<400>  162

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  163
<211>  15
<212>  PRT
<213>  Mouse

<220>
<223>  L-FR2 mouse R35B9, 41C, LV4, LV5

<400>  163

Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  164
<211>  15
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR2 human LV0

<400>  164

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  165
<211>  15
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR2 humanized LV1a

<400>  165

Trp Leu Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  166
<211>  15
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR2 humanized LV1b

<400>  166

Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  167
<211>  15
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR2 humanized LV3a

<400>  167

Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  168
<211>  15
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR2 humanized LV3b

<400>  168

Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  169
<211>  32
<212>  PRT
<213>  Mouse

<220>
<223>  L-FR3 mouse R35B9 and 41c

<400>  169

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  170
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR3 human LV0, LV1a, LV1b, LV3a, LV3b, LV4, LV5

<400>  170

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  171
<211>  10
<212>  PRT
<213>  Mouse

<220>
<223>  L-FR4 mouse R35B9, 41c, LV5

<400>  171

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  172
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR4 human LV0, LV1a, LV1b, LV3a, LV3b, LV4

<400>  172

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  173
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV0

<400>  173

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  174
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV0

<400>  174

Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  175
<211>  232
<212>  PRT
<213>  Mouse

<220>
<223>  41C mIgG1 heavy chain for crystal

<400>  175

Leu Glu Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Asp Tyr Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser 
65                  70                  75                  80  


Ala Tyr Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Thr Ser Gly Gln Ala 
    210                 215                 220                 


Gly Gln His His His His His His 
225                 230         


<210>  176
<211>  221
<212>  PRT
<213>  Mouse

<220>
<223>  41C mK light chain for crystal

<400>  176

Ser Arg Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Ala 
1               5                   10                  15      


Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu 
            20                  25                  30          


Asn Ser Ala Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly 
        35                  40                  45              


Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly 
    50                  55                  60                  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
65                  70                  75                  80  


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp 
                85                  90                  95      


Gln Gly Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
        115                 120                 125             


Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn 
    130                 135                 140                 


Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser 
145                 150                 155                 160 


Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys 
                165                 170                 175     


Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu 
            180                 185                 190         


Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser 
        195                 200                 205             


Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 220     


<210>  177
<211>  224
<212>  PRT
<213>  Mouse

<220>
<223>  R35B9 mIgG1 heavy fab frag for crystal

<400>  177

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Glu Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Val Pro Arg Asp Cys Gly His His His His His His 
    210                 215                 220                 


<210>  178
<211>  219
<212>  PRT
<213>  Mouse

<220>
<223>  R35B9 mK light chain for crystal

<400>  178

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  179
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9-VH_HV0

<400>  179

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  180
<211>  345
<212>  DNA
<213>  Mouse

<220>
<223>  R35B9(Y50)-VH

<400>  180
gaggtgcagc tgcagcaaag cggcccggag ctggtgaaac cgggtgcgag cgttaaaatg       60

agctgcaagg cgagcggtta catttttcag gattataata tgcattgggt taaacagagc      120

cacggtaaaa gcctggagtg gatcggctat attaatccgc gtaatggttg gaccaactat      180

aaccaaaagt tcaaaggcaa ggcgaccctg accgtgaaca agagcagccg tagcgcgtac      240

atggagtttc gtagcctgac cagcgaagat agcgcggttt actattgcgc gtcttcgggg      300

tggttcacgt attggggtca aggcaccctg gtgaccgtta gcgcg                      345


<210>  181
<211>  115
<212>  PRT
<213>  Mouse

<220>
<223>  R35B9(Y50)-VH

<400>  181

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  182
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subdomain 1 (AA30-50)

<400>  182

Ala Pro Gly Thr Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser Ala Asp 
1               5                   10                  15      


Leu Asp Lys Cys Met 
            20      


<210>  183
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subdomain 2 (AA51-70)

<400>  183

Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys Leu Gly 
1               5                   10                  15      


Cys Ala Ala Ala 
            20  


<210>  184
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus CDR H1


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is T, I or R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is T or Q

<400>  184

Gly Tyr Xaa Phe Xaa Asp Tyr Asn Met His 
1               5                   10  


<210>  185
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus CDR H2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Y or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is N or R

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is G or W

<400>  185

Xaa Ile Asn Pro Xaa Asn Xaa Xaa Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  186
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus CDR L3


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is H or F

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is F or Y

<400>  186

Trp Gln Gly Thr Xaa Xaa Pro Trp Thr 
1               5                   


<210>  187
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Consensus CDR H2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Y or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is G or W

<400>  187

Xaa Ile Asn Pro Arg Asn Xaa Xaa Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second Consensus CDR L3


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is H or F

<400>  188

Trp Gln Gly Thr Xaa Tyr Pro Trp Thr 
1               5                   


<210>  189
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R35B9(G57)-VH A428 nucleotide

<400>  189
gaggtgcagc tgcagcaaag cggcccggag ctggtgaaac cgggtgcgag cgttaaaatg       60

agctgcaagg cgagcggtta catttttcag gattataata tgcattgggt taaacagagc      120

cacggtaaaa gcctggagtg gatcggctct attaatccgc gtaatggtgg gaccaactat      180

aaccaaaagt tcaaaggcaa ggcgaccctg accgtgaaca agagcagccg tagcgcgtac      240

atggagtttc gtagcctgac cagcgaagat agcgcggttt actattgcgc gtcttcgggg      300

tggttcacgt attggggtca aggcaccctg gtgaccgtta gcgcg                      345


<210>  190
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R35B9(G57)-VH A428 amino acid

<400>  190

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  191
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R35B9(T28)-VH A435 nucleotide

<400>  191
gaggtgcagc tgcagcaaag cggcccggag ctggtgaaac cgggtgcgag cgttaaaatg       60

agctgcaagg cgagcggtta cacctttcag gattataata tgcattgggt taaacagagc      120

cacggtaaaa gcctggagtg gatcggctct attaatccgc gtaatggttg gaccaactat      180

aaccaaaagt tcaaaggcaa ggcgaccctg accgtgaaca agagcagccg tagcgcgtac      240

atggagtttc gtagcctgac cagcgaagat agcgcggttt actattgcgc gtcttcgggg      300

tggttcacgt attggggtca aggcaccctg gtgaccgtta gcgcg                      345


<210>  192
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R35B9(T28)-VH A435 amino acid

<400>  192

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  193
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R35B9(T30)-VH A436 nucleotide

<400>  193
gaggtgcagc tgcagcaaag cggcccggag ctggtgaaac cgggtgcgag cgttaaaatg       60

agctgcaagg cgagcggtta catttttact gattataata tgcattgggt taaacagagc      120

cacggtaaaa gcctggagtg gatcggctct attaatccgc gtaatggttg gaccaactat      180

aaccaaaagt tcaaaggcaa ggcgaccctg accgtgaaca agagcagccg tagcgcgtac      240

atggagtttc gtagcctgac cagcgaagat agcgcggttt actattgcgc gtcttcgggg      300

tggttcacgt attggggtca aggcaccctg gtgaccgtta gcgcg                      345


<210>  194
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R35B9(T30)-VH A436 amino acid

<400>  194

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  195
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R35B9(N54)-VH A438 nucleotide

<400>  195
gaggtgcagc tgcagcaaag cggcccggag ctggtgaaac cgggtgcgag cgttaaaatg       60

agctgcaagg cgagcggtta catttttcag gattataata tgcattgggt taaacagagc      120

cacggtaaaa gcctggagtg gatcggctct attaatccga ataatggttg gaccaactat      180

aaccaaaagt tcaaaggcaa ggcgaccctg accgtgaaca agagcagccg tagcgcgtac      240

atggagtttc gtagcctgac cagcgaagat agcgcggttt actattgcgc gtcttcgggg      300

tggttcacgt attggggtca aggcaccctg gtgaccgtta gcgcg                      345


<210>  196
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R35B9(N54)-VH A438 amino acid

<400>  196

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Asn Asn Gly Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  197
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41C(R28Q30R54)-VH A450 nucleotide

<400>  197
gaggtgcagc tgcagcaaag cggcccggag ctggtgaaac cgggtgcgag cgttaaaatg       60

agctgcaagg cgagcggtta caggtttcag gattataata tgcattgggt taaacagagc      120

cacggtaaaa gcctggagtg gatcggctat attaatccgc gtaatggtgg gaccaactat      180

aaccaaaagt tcaaaggcaa ggcgaccctg accgtgaaca agagcagccg tagcgcgtac      240

atggagtttc gtagcctgac cagcgaagat agcgcggttt actattgcgc gtcttcgggg      300

tggttcacgt attggggtca aggcaccctg gtgaccgtta gcgcg                      345


<210>  198
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41C(R28Q30R54)-VH A450 amino acid

<400>  198

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Arg Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Arg Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  199
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R35B9(F99)-VL A440 nucleotide

<400>  199
gacgtggtta tgacccaaac cccgctgacc ctgagcgtgg cgattggtca gccggcgagc       60

attagctgca agagcagcca aagcctgctg aacagcgcgg gtaaaaccta cctgaactgg      120

ctgctgcagc gtccgggtca aagcccgaag cgtctgatct atctggtgag ccagctggac      180

agcggtgtgc cggaccgttt caccggtagc ggtagcggca ccgactttac cctgaaaatt      240

agccgtgtgg aggcggaaga tctgggtgtt tactattgct ggcaaggtac tttttttccg      300

tggacctttg gtggcggtac caagctggag atcaaa                                336


<210>  200
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R35B9(F99)-VL A440 amino acid

<400>  200

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Ala Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  201
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hzR35B9-VH_HV0 (nucleotide corresponding to amino acid SEQ ID NO:
       179)

<400>  201
caagtccaac tggtccaaag cggggcagag gtaaagaagc caggtgcatc tgtaaaagtg       60

tcatgcaaag cctctgggta cacttttaca gactacaata tgcactgggt tcgtcaggct      120

cccggccagg gcctggagtg gatggggtcc ataaatccta ggaatggatg gacaaactat      180

aaccaaaaat tcaaaggtcg cgtaacaatt accgccgaca catcaacttc cacagcctat      240

atggaactca gcagtctgcg ctccgaagat actgccgtat attactgtgc ccgatccggc      300

tggttcacat actgggggca aggcacactt gtgactgtct ccagc                      345


<210>  202
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV12a nucleotide

<400>  202
caagttcaac ttgtccaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt tagacaggca      120

gacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcaaagggag agctactatc actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  203
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV12a amino acid

<400>  203

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Asp Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  204
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV12b nucleotide

<400>  204
caagttcaac ttgtccaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt tagacaggca      120

cccggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcaaagggag agctactatc actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  205
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV12b amino acid

<400>  205

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  206
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV13a nucleotide

<400>  206
caagttcaac ttgtccaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt tagagaagca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcaaagggag agctactatc actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  207
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV13a amino acid

<400>  207

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Glu Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  208
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV13b nucleotide

<400>  208
caagttcaac ttgtccaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt tagacaggca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcggagggag agctactatc actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  209
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV13b amino acid

<400>  209

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gly Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  210
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV13d nucleotide

<400>  210
caagttcaac ttgtccaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggg cagacaggca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcaaagggag agctactatc actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  211
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV13d amino acid

<400>  211

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Gly Arg Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  212
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV13f nucleotide

<400>  212
caagttcaac ttgtccaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt tagacaggca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aacgataagt tcaaagggag agctactatc actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  213
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV13f amino acid

<400>  213

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  214
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV13g nucleotide

<400>  214
caagttcaac ttgtccaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt tagacaggca      120

cacggtgact cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcaaagggag agctactatc actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  215
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV13g amino acid

<400>  215

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala His Gly Asp Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  216
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV16 nucleotide

<400>  216
caagttcaac ttcagcaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt taaacaggca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcaaagggaa agctactctg actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  217
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV16 amino acid

<400>  217

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  218
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV17a nucleotide

<400>  218
caagttcaac ttcagcaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt taaacaggga      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcaaagggaa agctactctg actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  219
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV17a amino acid

<400>  219

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Gly His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  220
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV17b nucleotide

<400>  220
caagttcaac ttcagcaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt taaacaggca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tccacgggaa agctactctg actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  221
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV17b amino acid

<400>  221

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


His Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  222
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV17d nucleotide

<400>  222
caagttcaac ttcagcaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt taaacaggca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcgacgggaa agctactctg actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  223
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV17d amino acid

<400>  223

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asp Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  224
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV17g nucleotide

<400>  224
caagttcaac ttcagcaatc cggtccagaa gtcgtaaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt taaacaggca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aacgacaagt tcaaagggaa agctactctg actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  225
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV17g amino acid

<400>  225

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  226
<211>  345
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV17i nucleotide

<400>  226
caagttcaac ttcagcaatc cggtccagaa gtcgccaaac caggtgctag tgtgaaagtc       60

tcatgcaagg cttcaggcta catatttcaa gactataata tgcattgggt taaacaggca      120

cacggtcagt cactggaatg gatggggtca atcaaccctc gcaacgcctg gacaaattac      180

aaccaaaagt tcaaagggaa agctactctg actgtcgata aatctaccag aacagcttac      240

atggagctga gtagtctgag atcagaggac accgccgtct actattgtgc ttcttctggg      300

tggtttacat actgggggca ggggacactg gtgactgtga gttct                      345


<210>  227
<211>  115
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-HV17i amino acid

<400>  227

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Gln Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ala His Gly Gln Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  228
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-LV2a nucleotide

<400>  228
gatgtagtaa tgacccagtc cccacttagc ttgcccgtta cactcggcca acccgcaagc       60

atatcttgca aatccagtca gagcctcctg aactctgctg gaaagaccta tctgaattgg      120

cttcaacaac gtcccggtca atcccccaga cgaggtatct acttggtaag tcagcttgac      180

tccggggttc cagacaggtt ttccggatct ggaagtggaa ctgattttac actcaaaatt      240

agtcgagtcg aggccgaaga cgtgggtgtc tattattgct ggcaaggcac cttttatcca      300

tggacttttg gtgggggcac caaggttgaa attaag                                336


<210>  229
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-LV2a amino acid

<400>  229

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Gly Ile Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  230
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-LV2b nucleotide

<400>  230
gatgtagtaa tgacccagtc cccacttagc ttgcccgtta cactcggcca acccgcaagc       60

atatcttgca aatccagtca gagcctcctg aactctgctg gaaagaccta tctgaattgg      120

cttcaacaac gtcccggtca atcccccaga cgacttgcct acttggtaag tcagcttgac      180

tccggggttc cagacaggtt ttccggatct ggaagtggaa ctgattttac actcaaaatt      240

agtcgagtcg aggccgaaga cgtgggtgtc tattattgct ggcaaggcac cttttatcca      300

tggacttttg gtgggggcac caaggttgaa attaag                                336


<210>  231
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-LV2b amino acid

<400>  231

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ala Tyr Leu Val Ser Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  232
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-LV2c nucleotide

<400>  232
gatgtagtaa tgacccagtc cccacttagc ttgcccgtta cactcggcca acccgcaagc       60

atatcttgca aatccagtca gagcctcctg aactctgctg gaaagaccta tctgaattgg      120

cttcaacaac gtcccggtca atcccccaga cgacttatct acttggtaag tgagcttgac      180

tccggggttc cagacaggtt ttccggatct ggaagtggaa ctgattttac actcaaaatt      240

agtcgagtcg aggccgaaga cgtgggtgtc tattattgct ggcaaggcac cttttatcca      300

tggacttttg gtgggggcac caaggttgaa attaag                                336


<210>  233
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-LV2c amino acid

<400>  233

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  234
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-LV2d nucleotide

<400>  234
gatgtagtaa tgacccagtc cccacttagc ttgcccgtta cactcggcca acccgcaagc       60

atatcttgca aatccagtca gagcctcctg aactctgctg gaaagaccta tctgaattgg      120

cttcaacaac gtcccggtca atcccccaga cgacttatct acttggtaag tcagcttgac      180

gacggggttc cagacaggtt ttccggatct ggaagtggaa ctgattttac actcaaaatt      240

agtcgagtcg aggccgaaga cgtgggtgtc tattattgct ggcaaggcac cttttatcca      300

tggacttttg gtgggggcac caaggttgaa attaag                                336


<210>  235
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-LV2d amino acid

<400>  235

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Gln Leu Asp Asp Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  236
<211>  336
<212>  DNA
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-LV2f nucleotide

<400>  236
gatgtagtaa tgacccagtc cccacttagc ttgcccgtta cactcggcca acccgcaagc       60

atatcttgca aatccagtca gagcctcctg aactctgctg gaaagaccta tctgaattgg      120

cttcaacaac gtcccggtca atcccccaga cgacttatct acttggtagc ccagcttgac      180

tccggggttc cagacaggtt ttccggatct ggaagtggaa ctgattttac actcaaaatt      240

agtcgagtcg aggccgaaga cgtgggtgtc tattattgct ggcaaggcac cttttatcca      300

tggacttttg gtgggggcac caaggttgaa attaag                                336


<210>  237
<211>  112
<212>  PRT
<213>  Homo sapiens

<220>
<223>  hzR35B9(A56)-LV2f amino acid

<400>  237

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ala Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ala Gln Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr Phe Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  238
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR1 humanized HV16, HV17a, HV17b, HV17d, HV17g,

<400>  238

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  239
<211>  25
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR1 humanized HV17i

<400>  239

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  240
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV12a

<400>  240

Trp Val Arg Gln Ala Asp Gly Gln Ser Leu Glu Trp Met Gly 
1               5                   10                  


<210>  241
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV12b

<400>  241

Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Met Gly 
1               5                   10                  


<210>  242
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV13a

<400>  242

Trp Val Arg Glu Ala His Gly Gln Ser Leu Glu Trp Met Gly 
1               5                   10                  


<210>  243
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV13d

<400>  243

Trp Gly Arg Gln Ala His Gly Gln Ser Leu Glu Trp Met Gly 
1               5                   10                  


<210>  244
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV13g

<400>  244

Trp Val Arg Gln Ala His Gly Asp Ser Leu Glu Trp Met Gly 
1               5                   10                  


<210>  245
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized HV16, HV17b, HV17d, HV17g, HV17i

<400>  245

Trp Val Lys Gln Ala His Gly Gln Ser Leu Glu Trp Met Gly 
1               5                   10                  


<210>  246
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR2 humanized 17a

<400>  246

Trp Val Lys Gln Gly His Gly Gln Ser Leu Glu Trp Met Gly 
1               5                   10                  


<210>  247
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-CDR2 deimmunized HV13b

<400>  247

Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe Gly 
1               5                   10                  15      


Gly 
    


<210>  248
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-CDR2 deimmunized HV17d

<400>  248

Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe Asp 
1               5                   10                  15      


Gly 
    


<210>  249
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-CDR2 deimmunized HV13f, HV17g

<400>  249

Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Asp Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  250
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-CDR2 humanized HV17b

<400>  250

Ser Ile Asn Pro Arg Asn Ala Trp Thr Asn Tyr Asn Gln Lys Phe His 
1               5                   10                  15      


Gly 
    


<210>  251
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  H-FR3 humanized HV16, HV17a, HV17b, HV17d, HV17g, HV17i

<400>  251

Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Arg Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  252
<211>  15
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR2 humanized LV2a

<400>  252

Trp Leu Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Gly Ile Tyr 
1               5                   10                  15  


<210>  253
<211>  15
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-FR2 humanized LV2b

<400>  253

Trp Leu Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ala Tyr 
1               5                   10                  15  


<210>  254
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-CDR2 humanized LV2d

<400>  254

Leu Val Ser Gln Leu Asp Asp 
1               5           


<210>  255
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-CDR2 humanized LV2c

<400>  255

Leu Val Ser Glu Leu Asp Ser 
1               5           


<210>  256
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223>  L-CDR2 humanized LV2f

<400>  256

Leu Val Ala Gln Leu Asp Ser 
1               5           


<210>  257
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third Consensus CDR H2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Y or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is N or R

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is G or W

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is Q or D

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is K, G, H, or D

<400>  257

Xaa Ile Asn Pro Xaa Asn Xaa Xaa Thr Asn Tyr Asn Xaa Lys Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus CDR L2


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is S or A

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is Q or E

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is S or D

<400>  258

Leu Val Xaa Xaa Leu Asp Xaa 
1               5           


<210>  259
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fourth Consensus CDR H2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is Y or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is A or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is G or W

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is Q or D

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is K, G, H, or D

<400>  259

Xaa Ile Asn Pro Arg Asn Xaa Xaa Thr Asn Tyr Asn Xaa Lys Phe Xaa 
1               5                   10                  15      


Gly 
    


