                         SEQUENCE LISTING

<110>  Gyroscope Therapeutics Limited
 
<120>  CODON-OPTIMISED COMPLEMENT FACTOR I

<130>  P116471PCT

<140>  PCT/GB2019/053668
<141>  2019-12-20

<150>  GB 1821089.8
<151>  2018-12-21

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  2
<211>  1752
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaagcttc ttcatgtttt cctgttattt ctgtgcttcc acttaaggtt ttgcaaggtc       60

acttatacat ctcaagagga tctggtggag aaaaagtgct tagcaaaaaa atatactcac      120

ctctcctgcg ataaagtctt ctgccagcca tggcagagat gcattgaggg cacctgtgtt      180

tgtaaactac cgtatcagtg cccaaagaat ggcactgcag tgtgtgcaac taacaggaga      240

agcttcccaa catactgtca acaaaagagt ttggaatgtc ttcatccagg gacaaagttt      300

ttaaataacg gaacatgcac agccgaagga aagtttagtg tttccttgaa gcatggaaat      360

acagattcag agggaatagt tgaagtaaaa cttgtggacc aagataagac aatgttcata      420

tgcaaaagca gctggagcat gagggaagcc aacgtggcct gccttgacct tgggtttcaa      480

caaggtgctg atactcaaag aaggtttaag ttgtctgatc tctctataaa ttccactgaa      540

tgtctacatg tgcattgccg aggattagag accagtttgg ctgaatgtac ttttactaag      600

agaagaacta tgggttacca ggatttcgct gatgtggttt gttatacaca gaaagcagat      660

tctccaatgg atgacttctt tcagtgtgtg aatgggaaat acatttctca gatgaaagcc      720

tgtgatggta tcaatgattg tggagaccaa agtgatgaac tgtgttgtaa agcatgccaa      780

ggcaaaggct tccattgcaa atcgggtgtt tgcattccaa gccagtatca atgcaatggt      840

gaggtggact gcattacagg ggaagatgaa gttggctgtg caggctttgc atctgtggct      900

caagaagaaa cagaaatttt gactgctgac atggatgcag aaagaagacg gataaaatca      960

ttattaccta aactatcttg tggagttaaa aacagaatgc acattcgaag gaaacgaatt     1020

gtgggaggaa agcgagcaca actgggagac ctcccatggc aggtggcaat taaggatgcc     1080

agtggaatca cctgtggggg aatttatatt ggtggctgtt ggattctgac tgctgcacat     1140

tgtctcagag ccagtaaaac tcatcgttac caaatatgga caacagtagt agactggata     1200

caccccgacc ttaaacgtat agtaattgaa tacgtggata gaattatttt ccatgaaaac     1260

tacaatgcag gcacttacca aaatgacatc gctttgattg aaatgaaaaa agacggaaac     1320

aaaaaagatt gtgagctgcc tcgttccatc cctgcctgtg tcccctggtc tccttaccta     1380

ttccaaccta atgatacatg catcgtttct ggctggggac gagaaaaaga taacgaaaga     1440

gtcttttcac ttcagtgggg tgaagttaaa ctaataagca actgctctaa gttttacgga     1500

aatcgtttct atgaaaaaga aatggaatgt gcaggtacat atgatggttc catcgatgcc     1560

tgtaaagggg actctggagg ccccttagtc tgtatggatg ccaacaatgt gacttatgtc     1620

tggggtgttg tgagttgggg ggaaaactgt ggaaaaccag agttcccagg tgtttacacc     1680

aaagtggcca attattttga ctggattagc taccatgtag gaaggccttt tatttctcag     1740

tacaatgtat aa                                                         1752


<210>  3
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  4
<211>  3696
<212>  DNA
<213>  Homo sapiens

<400>  4
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agcagaagat       60

tgcaatgaac ttcctccaag aagaaataca gaaattctga caggttcctg gtctgaccaa      120

acatatccag aaggcaccca ggctatctat aaatgccgcc ctggatatag atctcttgga      180

aatgtaataa tggtatgcag gaagggagaa tgggttgctc ttaatccatt aaggaaatgt      240

cagaaaaggc cctgtggaca tcctggagat actccttttg gtacttttac ccttacagga      300

ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg      360

ctaggtgaga ttaattaccg tgaatgtgac acagatggat ggaccaatga tattcctata      420

tgtgaagttg tgaagtgttt accagtgaca gcaccagaga atggaaaaat tgtcagtagt      480

gcaatggaac cagatcggga ataccatttt ggacaagcag tacggtttgt atgtaactca      540

ggctacaaga ttgaaggaga tgaagaaatg cattgttcag acgatggttt ttggagtaaa      600

gagaaaccaa agtgtgtgga aatttcatgc aaatccccag atgttataaa tggatctcct      660

atatctcaga agattattta taaggagaat gaacgatttc aatataaatg taacatgggt      720

tatgaataca gtgaaagagg agatgctgta tgcactgaat ctggatggcg tccgttgcct      780

tcatgtgaag aaaaatcatg tgataatcct tatattccaa atggtgacta ctcaccttta      840

aggattaaac acagaactgg agatgaaatc acgtaccagt gtagaaatgg tttttatcct      900

gcaacccggg gaaatacagc aaaatgcaca agtactggct ggatacctgc tccgagatgt      960

accttgaaac cttgtgatta tccagacatt aaacatggag gtctatatca tgagaatatg     1020

cgtagaccat actttccagt agctgtagga aaatattact cctattactg tgatgaacat     1080

tttgagactc cgtcaggaag ttactgggat cacattcatt gcacacaaga tggatggtcg     1140

ccagcagtac catgcctcag aaaatgttat tttccttatt tggaaaatgg atataatcaa     1200

aatcatggaa gaaagtttgt acagggtaaa tctatagacg ttgcctgcca tcctggctac     1260

gctcttccaa aagcgcagac cacagttaca tgtatggaga atggctggtc tcctactccc     1320

agatgcatcc gtgtcaaaac atgttccaaa tcaagtatag atattgagaa tgggtttatt     1380

tctgaatctc agtatacata tgccttaaaa gaaaaagcga aatatcaatg caaactagga     1440

tatgtaacag cagatggtga aacatcagga tcaattacat gtgggaaaga tggatggtca     1500

gctcaaccca cgtgcattaa atcttgtgat atcccagtat ttatgaatgc cagaactaaa     1560

aatgacttca catggtttaa gctgaatgac acattggact atgaatgcca tgatggttat     1620

gaaagcaata ctggaagcac cactggttcc atagtgtgtg gttacaatgg ttggtctgat     1680

ttacccatat gttatgaaag agaatgcgaa cttcctaaaa tagatgtaca cttagttcct     1740

gatcgcaaga aagaccagta taaagttgga gaggtgttga aattctcctg caaaccagga     1800

tttacaatag ttggacctaa ttccgttcag tgctaccact ttggattgtc tcctgacctc     1860

ccaatatgta aagagcaagt acaatcatgt ggtccacctc ctgaactcct caatgggaat     1920

gttaaggaaa aaacgaaaga agaatatgga cacagtgaag tggtggaata ttattgcaat     1980

cctagatttc taatgaaggg acctaataaa attcaatgtg ttgatggaga gtggacaact     2040

ttaccagtgt gtattgtgga ggagagtacc tgtggagata tacctgaact tgaacatggc     2100

tgggcccagc tttcttcccc tccttattac tatggagatt cagtggaatt caattgctca     2160

gaatcattta caatgattgg acacagatca attacgtgta ttcatggagt atggacccaa     2220

cttccccagt gtgtggcaat agataaactt aagaagtgca aatcatcaaa tttaattata     2280

cttgaggaac atttaaaaaa caagaaggaa ttcgatcata attctaacat aaggtacaga     2340

tgtagaggaa aagaaggatg gatacacaca gtctgcataa atggaagatg ggatccagaa     2400

gtgaactgct caatggcaca aatacaatta tgcccacctc cacctcagat tcccaattct     2460

cacaatatga caaccacact gaattatcgg gatggagaaa aagtatctgt tctttgccaa     2520

gaaaattatc taattcagga aggagaagaa attacatgca aagatggaag atggcagtca     2580

ataccactct gtgttgaaaa aattccatgt tcacaaccac ctcagataga acacggaacc     2640

attaattcat ccaggtcttc acaagaaagt tatgcacatg ggactaaatt gagttatact     2700

tgtgagggtg gtttcaggat atctgaagaa aatgaaacaa catgctacat gggaaaatgg     2760

agttctccac ctcagtgtga aggccttcct tgtaaatctc cacctgagat ttctcatggt     2820

gttgtagctc acatgtcaga cagttatcag tatggagaag aagttacgta caaatgtttt     2880

gaaggttttg gaattgatgg gcctgcaatt gcaaaatgct taggagaaaa atggtctcac     2940

cctccatcat gcataaaaac agattgtctc agtttaccta gctttgaaaa tgccataccc     3000

atgggagaga agaaggatgt gtataaggcg ggtgagcaag tgacttacac ttgtgcaaca     3060

tattacaaaa tggatggagc cagtaatgta acatgcatta atagcagatg gacaggaagg     3120

ccaacatgca gagacacctc ctgtgtgaat ccgcccacag tacaaaatgc ttatatagtg     3180

tcgagacaga tgagtaaata tccatctggt gagagagtac gttatcaatg taggagccct     3240

tatgaaatgt ttggggatga agaagtgatg tgtttaaatg gaaactggac ggaaccacct     3300

caatgcaaag attctacagg aaaatgtggg ccccctccac ctattgacaa tggggacatt     3360

acttcattcc cgttgtcagt atatgctcca gcttcatcag ttgagtacca atgccagaac     3420

ttgtatcaac ttgagggtaa caagcgaata acatgtagaa atggacaatg gtcagaacca     3480

ccaaaatgct tacatccgtg tgtaatatcc cgagaaatta tggaaaatta taacatagca     3540

ttaaggtgga cagccaaaca gaagctttat tcgagaacag gtgaatcagt tgaatttgtg     3600

tgtaaacggg gatatcgtct ttcatcacgt tctcacacat tgcgaacaac atgttgggat     3660

gggaaactgg agtatccaac ttgtgcaaaa agatag                               3696


<210>  5
<211>  934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example promoter sequence

<400>  5
attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg       60

tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat      120

gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca      180

gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat      240

taccatggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc      300

acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg gggcgggggg      360

gggggggggg cgcgcgccag gcggggcggg gcggggcgag gggcggggcg gggcgaggcg      420

gagaggtgcg gcggcagcca atcagagcgg cgcgctccga aagtttcctt ttatggcgag      480

gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg cgggcgggag tcgctgcgcg      540

ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact      600

gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg gctgtaatta      660

gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc ttgaggggct      720

ccgggagggc cctttgtgcg gggggagcgg ctcggggctg tccgcggggg gacggctgcc      780

ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc ggctctagag      840

cctctgctaa ccatgttcat gccttcttct ttttcctaca gctcctgggc aacgtgctgg      900

ttattgtgct gtctcatcat tttggcaaag aatt                                  934


<210>  6
<211>  270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bovine Growth Hormone poly-A (bGH poly-A) signal sequence

<400>  6
tcgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc       60

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga      120

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga      180

cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat      240

ggcttctgag gcggaaagaa ccagctgggg                                       270


<210>  7
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example woodchuck hepatitis post-transcriptional regulatory 
       element (WPRE) sequence

<400>  7
atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc       60

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta      120

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt      180

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg      240

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta      300

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt      360

tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg      420

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca      480

atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc      540

gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgc                   588


<210>  8
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimised nucleotide sequence encoding Complement Factor I

<400>  8
atgaagctgc tgcatgtctt tctgctgttt ctgtgcttcc atctgcggtt ctgtaaagtg       60

acctatacta gccaggagga tctggtggag aagaagtgtc tggccaagaa gtacacacac      120

ctgagctgcg acaaggtgtt ctgtcagcct tggcagcggt gcatcgaggg cacctgcgtg      180

tgcaagctgc cttaccagtg cccaaagaac ggcaccgccg tgtgcgccac aaatcggaga      240

tcttttccaa catattgcca gcagaagagc ctggagtgtc tgcaccccgg caccaagttc      300

ctgaacaatg gcacctgcac agccgagggc aagttttctg tgagcctgaa gcacggcaac      360

acagatagcg agggcatcgt ggaggtgaag ctggtggacc aggataagac catgttcatc      420

tgtaagagct cctggtccat gagggaggca aacgtggcat gcctggatct gggattccag      480

cagggagcag acacacagag gcgctttaag ctgtccgacc tgtctatcaa tagcaccgag      540

tgcctgcacg tgcactgtag gggcctggag acatccctgg cagagtgcac cttcacaaag      600

cggagaacca tgggctacca ggactttgcc gacgtggtgt gctataccca gaaggccgat      660

agccccatgg acgatttctt tcagtgcgtg aacggcaagt atatctccca gatgaaggcc      720

tgcgacggca tcaatgactg tggcgatcag tctgacgagc tgtgctgtaa ggcctgtcag      780

ggcaagggct tccactgcaa gagcggcgtg tgcatccctt cccagtacca gtgcaacggc      840

gaggtggatt gtatcacagg agaggacgaa gtgggatgcg caggatttgc atctgtggca      900

caggaggaga cagagatcct gacagccgac atggatgccg agaggcgccg gatcaagtct      960

ctgctgccta agctgagctg tggcgtgaag aatcggatgc acatcagaag gaagcgcatc     1020

gtgggaggca agagggcaca gctgggcgat ctgccatggc aggtggccat caaggacgcc     1080

tctggcatca cctgcggcgg catctacatc ggaggatgtt ggatcctgac cgcagcacac     1140

tgcctgagag caagcaagac acacaggtat cagatctgga ccacagtggt ggattggatc     1200

cacccagacc tgaagagaat cgtgatcgag tacgtggata ggatcatctt tcacgagaac     1260

tacaatgccg gcacatatca gaacgacatc gccctgatcg agatgaagaa ggatggcaat     1320

aagaaggact gtgagctgcc cagatccatc cctgcatgcg tgccatggag cccctatctg     1380

ttccagccca acgatacctg catcgtgtcc ggatggggaa gggagaagga caatgagcgg     1440

gtgttttctc tgcagtgggg cgaggtgaag ctgatctcca actgttctaa gttctacggc     1500

aataggtttt atgagaagga gatggagtgc gccggcacct acgatggcag catcgacgcc     1560

tgtaagggcg attccggagg accactggtg tgcatggacg caaacaatgt gacatacgtg     1620

tggggagtgg tgtcctgggg agagaactgc ggcaagccag agttccccgg cgtatatacc     1680

aaggtggcca attattttga ttggatttcc taccacgtcg gcaggccctt tatttcccag     1740

tataatgtct aa                                                         1752


<210>  9
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Ala Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  10
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding Complement Factor I

<400>  10
atgaaactgc tgcatgtctt cctcctcttc ctgtgcttcc acctccgttt ctgtaaagtc       60

acctacacta gccaggagga tctggtggag aagaaatgcc tggccaagaa gtatacccac      120

ctgagctgcg acaaagtgtt ctgccagccc tggcaacgct gcattgaagg tacttgtgtg      180

tgcaagctgc cctaccagtg ccccaagaac ggcacggccg tgtgtgccac caacaggagg      240

agcttcccca cctactgcca gcagaagagc ctggaatgcc tccaccctgg caccaagttt      300

ctgaacaacg ggacctgcac agccgagggg aaattcagcg tctccctcaa gcacggcaat      360

acagactccg agggcattgt ggaagtgaag ctggtggacc aggacaagac catgttcatc      420

tgcaaaagca gctggtccat gcgggaggcc aatgtcgcct gcctggacct gggcttccag      480

cagggcgctg atacacagcg ccgctttaaa ctcagtgacc tcagcatcaa cagcactgag      540

tgtctgcacg tgcactgccg gggcctggag accagcctgg ctgagtgcac cttcaccaag      600

cgcaggacca tgggctacca ggattttgca gatgtggtct gctacaccca gaaggcagac      660

agccccatgg atgacttctt ccagtgtgtc aatggcaagt acatttccca gatgaaggct      720

tgtgacggga tcaatgattg cggggatcag agcgatgagc tctgctgcaa ggcctgccaa      780

gggaagggct ttcactgtaa gtctggggtg tgcatccctt ctcagtatca gtgcaacgga      840

gaggtggact gcatcactgg ggaggacgag gtgggctgtg ctggcttcgc ctctgtggcc      900

caggaggaga cagagatcct cacagctgac atggatgcag agcggcggcg catcaagagt      960

ctgctcccaa agctctcctg cggcgttaag aatcgcatgc acatccggag gaagcggatc     1020

gttggaggca aacgggctca gctgggggac ttgccgtggc aggtggccat caaagatgcc     1080

tccggaatca cctgtggtgg catctacatc ggcggctgct ggatcctgac cgccgcccac     1140

tgccttcggg ccagcaagac tcaccgctac cagatctgga ccaccgtggt ggattggatt     1200

caccccgacc tgaagaggat tgtcattgag tatgtcgacc gcatcatctt ccatgaaaac     1260

tacaatgccg ggacgtatca gaacgacatc gccctcatcg agatgaagaa ggatgggaac     1320

aagaaggact gtgagctgcc tcgctccatc cccgcctgtg taccatggtc tccgtacctg     1380

ttccagccaa atgacacatg catcgtgagc ggctggggcc gcgagaaaga caacgagagg     1440

gtcttctccc tgcagtgggg tgaagtcaag ctgatcagca actgctccaa gttctacggc     1500

aaccgcttct atgagaagga gatggagtgc gccggcacct atgacggcag cattgacgcg     1560

tgcaagggag acagtggggg ccccctggtc tgcatggacg ccaacaatgt gacctacgtg     1620

tggggagttg tgtcctgggg cgagaactgt ggcaagcctg agttcccggg cgtgtacaca     1680

aaggtggcaa actattttga ctggatctcc tatcacgttg gcaggccctt catttcacag     1740

tacaacgtat aa                                                         1752


<210>  11
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of Complement Factor H-like Protein 1 (FHL1)

<400>  11

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Ile Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu 
    


<210>  12
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding FHL1

<400>  12
atgcgcctcc tggccaagat catctgcctc atgctgtggg ccatctgcgt ggctgaggac       60

tgcaatgagc tgccgcccag gaggaacaca gagatcctga cagggagctg gtctgaccag      120

acctaccctg agggcaccca ggcgatctac aagtgccggc cgggctacag gagcctgggg      180

aacatcatca tggtgtgtag aaagggcgaa tgggtggccc tcaaccccct gaggaagtgc      240

cagaagcggc cctgtggcca ccccggggac acacccttcg ggaccttcac cctgaccggc      300

ggcaatgtgt ttgagtacgg cgtgaaggct gtctacacat gcaacgaggg gtaccagctg      360

ctgggcgaga ttaactaccg ggagtgtgac accgatgggt ggaccaacga cattcccatc      420

tgtgaggtgg tcaagtgtct ccccgtgaca gccccagaaa atggcaaaat cgtgagcagc      480

gccatggagc ctgaccgcga atatcacttt gggcaggccg tgaggtttgt gtgcaactcg      540

ggctacaaaa ttgaaggtga tgaggagatg cactgcagcg atgatggctt ctggtccaag      600

gagaagccca aatgtgtgga gatctcctgc aagtctcccg acgtgatcaa cggcagccca      660

atcagccaga agattattta caaagagaac gagcgcttcc agtacaagtg taacatgggc      720

tatgagtatt cagagagggg agatgccgtc tgcactgaga gcggctggag accactgcct      780

agctgcgagg aaaagagttg tgacaaccct tacatcccaa atggcgacta ctcccctctg      840

cggatcaaac accggaccgg ggatgaaatc acctatcagt gccgcaatgg attctacccg      900

gccacccgcg gcaacaccgc caaatgcacc agcacaggct ggatccccgc cccccgctgt      960

acgctgaagc cttgcgacta tccagacatc aagcacggag gcctgtacca cgaaaacatg     1020

cggcggcctt atttccctgt ggcagtgggg aagtactaca gctactactg cgacgagcac     1080

ttcgagaccc cctctggctc ctactgggac cacatccact gcacacagga cggctggtct     1140

ccagctgtgc cctgcctgag gaaatgctac ttcccctacc tggagaacgg atacaaccag     1200

aactatggcc gcaagttcgt gcagggcaag agcatcgatg tggcctgcca ccctggctac     1260

gccctgccca aggcccagac aactgtgacc tgcatggaga atggttggag ccccaccccg     1320

cgctgcatcc gggtgtcctt cacgctctga                                      1350


<210>  13
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example CMV (cytomegalovirus) promoter sequence

<400>  13
ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc       60

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      120

ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta      180

tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta      240

tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat      300

cgctattacc atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga      360

ctcacgggga tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca      420

aaatcaacgg gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg      480

taggcgtgta cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcgc      540

ctggagacgc catccacgct gttttgacct ccatagaaga caccg                      585


<210>  14
<211>  223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bovine Growth Hormone poly-A (bGH poly-A) signal sequence

<400>  14
gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg       60

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg      120

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg      180

gaagacaata gcaggcatgc tggggatgcg gtgggctcta tgg                        223


<210>  15
<211>  245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE3 sequence (shortened version of WPRE, contains only minimal 
       gamma and alpha elements)

<400>  15
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc      180

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc      240

gtggt                                                                  245


<210>  16
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GT005: CFI wild type sequence

<400>  16
atgaagcttc ttcatgtttt cctgttattt ctgtgcttcc acttaaggtt ttgcaaggtc       60

acttatacat ctcaagagga tctggtggag aaaaagtgct tagcaaaaaa atatactcac      120

ctctcctgcg ataaagtctt ctgccagcca tggcagagat gcattgaggg cacctgtgtt      180

tgtaaactac cgtatcagtg cccaaagaat ggcactgcag tgtgtgcaac taacaggaga      240

agcttcccaa catactgtca acaaaagagt ttggaatgtc ttcatccagg gacaaagttt      300

ttaaataacg gaacatgcac agccgaagga aagtttagtg tttccttgaa gcatggaaat      360

acagattcag agggaatagt tgaagtaaaa cttgtggacc aagataagac aatgttcata      420

tgcaaaagca gctggagcat gagggaagcc aacgtggcct gccttgacct tgggtttcaa      480

caaggtgctg atactcaaag aaggtttaag ttgtctgatc tctctataaa ttccactgaa      540

tgtctacatg tgcattgccg aggattagag accagtttgg ctgaatgtac ttttactaag      600

agaagaacta tgggttacca ggatttcgct gatgtggttt gttatacaca gaaagcagat      660

tctccaatgg atgacttctt tcagtgtgtg aatgggaaat acatttctca gatgaaagcc      720

tgtgatggta tcaatgattg tggagaccaa agtgatgaac tgtgttgtaa agcatgccaa      780

ggcaaaggct tccattgcaa atcgggtgtt tgcattccaa gccagtatca atgcaatggt      840

gaggtggact gcattacagg ggaagatgaa gttggctgtg caggctttgc atctgtggct      900

caagaagaaa cagaaatttt gactgctgac atggatgcag aaagaagacg gataaaatca      960

ttattaccta aactatcttg tggagttaaa aacagaatgc acattcgaag gaaacgaatt     1020

gtgggaggaa agcgagcaca actgggagac ctcccatggc aggtggcaat taaggatgcc     1080

agtggaatca cctgtggggg aatttatatt ggtggctgtt ggattctgac tgctgcacat     1140

tgtctcagag ccagtaaaac tcatcgttac caaatatgga caacagtagt agactggata     1200

caccccgacc ttaaacgtat agtaattgaa tacgtggata gaattatttt ccatgaaaac     1260

tacaatgcag gcacttacca aaatgacatc gctttgattg aaatgaaaaa agacggaaac     1320

aaaaaagatt gtgagctgcc tcgttccatc cctgcctgtg tcccctggtc tccttaccta     1380

ttccaaccta atgatacatg catcgtttct ggctggggac gagaaaaaga taacgaaaga     1440

gtcttttcac ttcagtgggg tgaagttaaa ctaataagca actgctctaa gttttacgga     1500

aatcgtttct atgaaaaaga aatggaatgt gcaggtacat atgatggttc catcgatgcc     1560

tgtaaagggg actctggagg ccccttagtc tgtatggatg ccaacaatgt gacttatgtc     1620

tggggtgttg tgagttgggg ggaaaactgt ggaaaaccag agttcccagg tgtttacacc     1680

aaagtggcca attattttga ctggattagc taccatgtag gaaggccttt tatttctcag     1740

tacaatgtat aa                                                         1752


<210>  17
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC001: FHL-1 wild type sequence

<400>  17
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agcagaagat       60

tgcaatgaac ttcctccaag aagaaataca gaaattctga caggttcctg gtctgaccaa      120

acatatccag aaggcaccca ggctatctat aaatgccgcc ctggatatag atctcttgga      180

aatataataa tggtatgcag gaagggagaa tgggttgctc ttaatccatt aaggaaatgt      240

cagaaaaggc cctgtggaca tcctggagat actccttttg gtacttttac ccttacagga      300

ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg      360

ctaggtgaga ttaattaccg tgaatgtgac acagatggat ggaccaatga tattcctata      420

tgtgaagttg tgaagtgttt accagtgaca gcaccagaga atggaaaaat tgtcagtagt      480

gcaatggaac cagatcggga ataccatttt ggacaagcag tacggtttgt atgtaactca      540

ggctacaaga ttgaaggaga tgaagaaatg cattgttcag acgatggttt ttggagtaaa      600

gagaaaccaa agtgtgtgga aatttcatgc aaatccccag atgttataaa tggatctcct      660

atatctcaga agattattta taaggagaat gaacgatttc aatataaatg taacatgggt      720

tatgaataca gtgaaagagg agatgctgta tgcactgaat ctggatggcg tccgttgcct      780

tcatgtgaag aaaaatcatg tgataatcct tatattccaa atggtgacta ctcaccttta      840

aggattaaac acagaactgg agatgaaatc acgtaccagt gtagaaatgg tttttatcct      900

gcaacccggg gaaatacagc aaaatgcaca agtactggct ggatacctgc tccgagatgt      960

accttgaaac cttgtgatta tccagacatt aaacatggag gtctatatca tgagaatatg     1020

cgtagaccat actttccagt agctgtagga aaatattact cctattactg tgatgaacat     1080

tttgagactc cgtcaggaag ttactgggat cacattcatt gcacacaaga tggatggtcg     1140

ccagcagtac catgcctcag aaaatgttat tttccttatt tggaaaatgg atataatcaa     1200

aattatggaa gaaagtttgt acagggtaaa tctatagacg ttgcctgcca tcctggctac     1260

gctcttccaa aagcgcagac cacagttaca tgtatggaga atggctggtc tcctactccc     1320

agatgcatcc gtgtcagctt taccctctga                                      1350


<210>  18
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC128: CFI GeneArt - Basic

<400>  18
atgaagctgc tgcatgtgtt tctgctgttc ctctgcttcc acctgaggtt ctgcaaagtg       60

acctacacca gccaagagga cctggtggaa aagaagtgcc tggccaagaa gtacacccac      120

ctgagctgcg acaaggtgtt ctgccagcct tggcagagat gcatcgaggg cacctgtgtg      180

tgcaagctgc cctatcagtg ccccaagaat ggcacagccg tgtgcgccac caacagaaga      240

agcttcccta cctactgcca gcagaaaagc ctggaatgtc tgcaccccgg caccaagttt      300

ctgaacaacg gcacctgtac cgccgagggc aagtttagcg tgtccctgaa gcacggcaac      360

accgactctg agggcatcgt ggaagtgaag ctggtggacc aggacaagac catgttcatc      420

tgcaagagca gctggtccat gcgcgaggcc aatgtggctt gtctggatct gggattccag      480

cagggcgccg acacacagag aagattcaag ctgagcgacc tgagcatcaa cagcaccgag      540

tgcctgcatg tgcactgtag aggcctggaa acaagcctgg ccgagtgcac cttcaccaag      600

agaaggacca tgggctacca ggacttcgcc gacgtcgtgt gctacaccca gaaagccgac      660

tctcccatgg acgatttctt ccagtgcgtg aacggcaagt acatcagcca gatgaaggcc      720

tgcgacggca tcaacgattg cggcgatcag agcgacgagc tgtgctgcaa agcctgtcaa      780

ggcaagggct tccactgcaa gtccggcgtg tgtatcccta gccagtacca gtgcaatggc      840

gaggtggact gtatcaccgg cgaggatgaa gtgggctgtg ccggatttgc cagcgtggcc      900

caagaggaaa ccgagatcct gaccgccgat atggacgccg agcggcggag aatcaaaagc      960

ctgctgccta agctgtcctg cggcgtgaag aaccggatgc acatccggcg caagagaatc     1020

gtcggaggca aaagagcaca gctgggcgat ctgccttggc aagtggccat caaggatgcc     1080

agcggcatca catgtggcgg catctacatc ggcggctgct ggattctgac agccgctcat     1140

tgtctgcggg ccagcaagac ccaccggtat cagatctgga ccaccgtggt ggactggatt     1200

caccccgacc tgaagcggat cgtgatcgag tacgtggacc ggatcatctt ccacgagaac     1260

tacaacgccg gcacctacca gaacgatatc gccctgatcg agatgaagaa ggacgggaac     1320

aagaaggact gcgagctgcc tagatctatc cccgcctgtg ttccttggag cccctacctg     1380

ttccagccta acgatacctg catcgtgtcc ggctggggca gagagaagga taacgagagg     1440

gtgttcagcc tgcagtgggg cgaagtgaaa ctgatcagca actgcagcaa gttctacggc     1500

aaccggttct acgagaaaga aatggaatgc gccggcacat acgacggctc catcgatgcc     1560

tgtaaaggcg attctggcgg ccctctcgtg tgcatggatg ccaacaatgt gacctacgtg     1620

tggggcgtcg tgtcctgggg agagaattgt ggcaagcctg agttccccgg cgtgtacacc     1680

aaggtggcca actacttcga ctggatcagc taccacgtgg gcagaccctt tatcagccag     1740

tacaacgtgt ga                                                         1752


<210>  19
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC129: CFI GeneArt - Manually optimised

<400>  19
atgaagctgc tccatgtgtt tctgctcttc ctctgcttcc acctgaggtt ctgcaaagtg       60

acctacacca gccaagagga cctggtggaa aagaaatgcc tggccaagaa atacacccac      120

ctgagctgcg acaaggtgtt ctgccagcct tggcagagat gcatcgaggg cacctgtgtg      180

tgcaagctgc cctatcagtg ccccaagaat ggcacagccg tgtgcgctac aaacagaagg      240

agcttcccta cctactgcca gcaaaaaagc ctggagtgcc tgcaccccgg caccaagttt      300

ctgaacaatg gcacctgtac cgccgagggc aagtttagcg tgtccctgaa gcacggcaac      360

accgactctg agggcatcgt ggaagtgaag ctggtggacc aggacaagac catgttcatc      420

tgcaagagct cctggtccat gcgcgaggcc aatgtggctt gtctggatct gggattccag      480

caaggcgccg acacacagag aaggttcaag ctgagcgacc tgagcatcaa cagcaccgag      540

tgcctgcatg tgcactgtag aggcctggaa acaagcctgg ccgagtgcac cttcaccaag      600

agaaggacca tgggctacca ggacttcgcc gacgtcgtgt gctacaccca gaaagccgac      660

tctcccatgg acgatttctt tcagtgcgtg aacggcaagt acatcagcca gatgaaggcc      720

tgcgacggca tcaacgattg cggcgatcag agcgacgagc tgtgctgtaa agcctgtcaa      780

ggcaagggct tccactgcaa gtccggcgtg tgtatcccta gccagtacca gtgcaatggc      840

gaggtggact gtatcaccgg cgaggatgaa gtgggctgtg ccggatttgc cagcgtggcc      900

caagaggaaa ccgagatcct gaccgccgat atggacgccg agcggaggag aatcaaaagc      960

ctgctcccta agctgtcctg cggcgtgaag aaccggatgc acatccggcg caagagaatc     1020

gtcggaggca aaagagcaca gctgggcgat ctgccttggc aagtggccat caaggatgcc     1080

agcggcatca catgtggcgg gatctacatc ggcggatgct ggattctgac agccgctcat     1140

tgtctgcggg ccagcaagac ccaccggtat cagatctgga ccacagtggt cgactggatt     1200

caccccgacc tgaagcggat cgtgatcgag tacgtggacc ggatcatttt ccacgagaac     1260

tacaacgccg gcacctacca gaacgatatc gccctgatcg agatgaaaaa ggacgggaac     1320

aagaaagact gcgagctgcc tagatctatc cccgcctgtg ttccttggag cccctacctg     1380

ttccagccta acgatacctg catcgtgtcc ggctggggca gagagaagga taacgagagg     1440

gtgttcagcc tgcagtgggg cgaagtgaaa ctgatcagca actgcagcaa gttctacggc     1500

aaccggttct acgagaaaga aatggaatgc gccggcacat acgacggctc catcgatgcc     1560

tgtaaaggcg attctggcgg acctctcgtg tgcatggatg ccaacaatgt gacctacgtg     1620

tggggcgtcg tgtcctgggg agagaattgt ggcaagcctg agttccccgg cgtgtacacc     1680

aaggtggcca actacttcga ctggatcagc taccacgtgg gcagaccctt tatcagccag     1740

tacaacgtgt ga                                                         1752


<210>  20
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC130: CFI Genscript - Basic

<400>  20
atgaagctgc tgcatgtctt tctgctgttt ctgtgcttcc atctgaggtt ctgcaaggtc       60

acttacacta gccaggagga tctggtcgag aagaagtgtc tggccaagaa gtacacacac      120

ctgagctgcg acaaggtgtt ctgtcagcct tggcagcggt gcatcgaggg cacctgcgtg      180

tgcaagctgc cttaccagtg cccaaagaac ggcaccgccg tgtgcgccac aaatcggaga      240

tcttttccaa catattgcca gcagaagagc ctggagtgtc tgcaccccgg caccaagttc      300

ctgaacaatg gcacctgcac agccgagggc aagttttctg tgagcctgaa gcacggcaac      360

acagatagcg agggcatcgt ggaggtgaag ctggtggacc aggataagac catgttcatc      420

tgtaagagca gctggtccat gagggaggca aacgtggcat gcctggatct gggattccag      480

cagggagcag acacacagag gcgctttaag ctgtccgacc tgtctatcaa tagcaccgag      540

tgcctgcacg tgcactgtag gggcctggag acatccctgg cagagtgcac cttcacaaag      600

cggagaacaa tgggctacca ggactttgcc gacgtggtgt gctataccca gaaggccgat      660

agccctatgg acgatttctt tcagtgcgtg aacggcaagt atatctccca gatgaaggcc      720

tgcgacggca tcaatgactg tggcgatcag tctgacgagc tgtgctgtaa ggcctgtcag      780

ggcaagggct tccactgcaa gagcggcgtg tgcatccctt cccagtacca gtgcaacggc      840

gaggtggatt gtatcacagg agaggacgaa gtgggatgcg caggatttgc atctgtggca      900

caggaggaga cagagatcct gacagccgac atggatgccg agaggcgccg gatcaagtct      960

ctgctgccta agctgagctg tggcgtgaag aatcggatgc acatcagaag gaagcgcatc     1020

gtgggaggca agcgggccca gctgggcgat ctgccctggc aggtggccat caaggacgcc     1080

tctggcatca cctgcggcgg catctacatc ggcggctgtt ggattctgac cgcagcacac     1140

tgcctgagag caagcaagac acacaggtat cagatctgga ccacagtggt ggattggatt     1200

cacccagacc tgaagagaat cgtgatcgag tacgtggata ggatcatctt ccacgagaac     1260

tacaatgccg gcacatatca gaacgacatc gccctgatcg agatgaagaa ggatggcaat     1320

aagaaggact gtgagctgcc cagatccatc cctgcatgcg tgccctggag cccctatctg     1380

ttccagccca acgatacctg catcgtgtcc ggatggggaa gggagaagga caatgagcgg     1440

gtgttttctc tgcagtgggg cgaggtgaag ctgatctcca actgttctaa gttctacggc     1500

aataggtttt atgagaagga gatggagtgc gccggcacct acgatggcag catcgacgcc     1560

tgtaagggcg attccggagg accactggtg tgcatggacg caaacaatgt gacatacgtg     1620

tggggagtgg tgtcctgggg agagaactgc ggcaagccag agtttcccgg cgtgtatacc     1680

aaggtggcca attattttga ttggatttca taccatgtcg ggagaccatt cattagtcag     1740

tacaacgtgt ga                                                         1752


<210>  21
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC131: CFI Genscript - Manually optimised

<400>  21
atgaagctgc tccatgtctt tctgctcttt ctgtgcttcc atctgaggtt ctgcaaggtc       60

acttacacta gccaggagga tctggtcgag aagaaatgtc tggccaagaa atacacacac      120

ctgagctgcg acaaggtgtt ctgtcagcct tggcagcggt gcatcgaggg cacctgcgtg      180

tgcaagctgc cttaccagtg cccaaagaac ggcaccgccg tgtgcgccac aaatcggaga      240

tcttttccaa catattgcca gcaaaagagc ctggagtgtc tgcaccccgg caccaagttc      300

ctgaacaatg gcacctgcac agccgagggc aagttttctg tgagcctgaa gcacggcaac      360

acagatagcg agggcatcgt ggaggtgaag ctggtggacc aggataagac catgttcatc      420

tgtaagagct cctggtccat gagggaggca aacgtggcat gcctggatct gggattccag      480

caaggagcag acacacagag gcgctttaag ctgtccgatc tgagtatcaa tagcaccgag      540

tgcctgcacg tgcactgtag gggcctggag acatccctgg cagagtgcac cttcacaaag      600

cggagaacaa tgggctacca ggactttgcc gacgtggtct gctataccca gaaggccgat      660

agccctatgg acgatttctt tcagtgcgtg aacggcaagt atatctccca gatgaaggcc      720

tgcgacggca tcaatgactg tggcgatcag tctgacgagc tgtgctgtaa ggcctgtcag      780

ggcaagggct tccactgcaa gagcggcgtg tgcatccctt cccagtacca gtgcaacggc      840

gaggtggatt gtatcacagg agaggacgaa gtgggatgcg caggatttgc atctgtggca      900

caggaggaaa cagagatcct gacagccgac atggatgccg agaggcgccg gatcaagtct      960

ctgctcccta agctgagctg tggcgtgaag aatcggatgc acatcagaag gaagcgcatc     1020

gtgggaggca agcgggccca gctgggcgat ctgccctggc aggtggccat caaggacgcc     1080

tctggcatca cctgcggcgg gatctacatc ggcggatgtt ggattctgac cgcagcccac     1140

tgcctgagag caagcaagac acacagatat cagatctgga ccacagtggt cgattggatt     1200

cacccagacc tgaagagaat cgtgatcgag tacgtggata ggatcatttt ccacgagaat     1260

tacaatgctg gcacatatca gaatgatatc gctctcatcg agatgaagaa agatggcaat     1320

aagaaagact gtgagctgcc cagatccatc cctgcatgcg tgccctggag cccctatctg     1380

ttccagccca acgatacctg catcgtgtcc ggatggggaa gggagaagga caatgagcgg     1440

gtgttttctc tgcagtgggg cgaggtgaag ctgatctcca actgttctaa gttctacggc     1500

aataggtttt atgagaagga gatggagtgc gccggcacct acgatggcag catcgacgcc     1560

tgtaagggcg attccggagg cccactggtg tgcatggacg caaacaatgt gacatacgtg     1620

tggggagtgg tctcctgggg agagaactgc ggcaagccag agtttcccgg cgtgtatacc     1680

aaggtggcca attattttga ttggatttca taccatgtcg ggagaccatt cattagtcaa     1740

tacaacgttt ga                                                         1752


<210>  22
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC132: CFI IDT - Basic

<400>  22
atgaagctcc tccacgtctt cttgttgttt ctctgtttcc acctgagatt ttgcaaagta       60

acttacacca gtcaagaaga cttggtcgag aagaagtgtc tcgccaaaaa gtatactcac      120

ctgagctgtg ataaagtgtt ctgtcagccg tggcagcgct gcattgaggg tacatgtgtc      180

tgtaaactgc cttatcagtg tccgaagaac ggtacggctg tctgtgctac taacagacgg      240

tcttttccta cttattgcca gcagaagagt ttggaatgtc tccaccctgg taccaagttt      300

ctcaacaatg gcacctgtac tgctgaaggt aaattctccg tcagtctcaa gcatggtaac      360

actgacagtg aagggatagt agaggtaaag ttggttgacc aggacaagac gatgttcata      420

tgcaagtcaa gctggtccat gcgcgaggcg aatgtcgctt gtcttgattt gggcttccag      480

caaggggcag acacacagag aagattcaaa ttgagcgacc tgagtataaa ttcaaccgag      540

tgcctccatg tacattgcag agggctcgag acttcacttg ccgaatgtac atttacgaag      600

aggcggacta tgggatatca ggactttgcc gacgtagtat gttatactca gaaagcagac      660

agtcctatgg atgacttttt ccaatgcgtc aacggcaaat acatcagtca aatgaaagcg      720

tgcgacggta tcaacgattg tggtgaccag tctgatgagc tttgctgtaa agcatgtcaa      780

ggaaaggggt tccattgcaa gagtggtgta tgtattccct cacaatatca gtgcaatggg      840

gaagtcgatt gcataacagg tgaggatgag gtgggctgcg cgggatttgc ttctgtggcg      900

caagaggaga ctgagatcct tacagcggat atggacgccg aacgaagacg catcaaatct      960

ctccttccca aactttcatg cggcgtcaaa aaccgaatgc atatacgcag gaagagaatt     1020

gttgggggaa agcgggcaca gctgggcgac ctcccctggc aagttgcaat aaaggatgca     1080

agtgggataa cgtgcggggg catctacatc ggggggtgct ggatcttgac tgccgcccac     1140

tgtcttagag cctctaagac ccataggtac caaatctgga caactgtagt tgactggata     1200

catccggacc ttaaacgcat agttattgaa tacgttgacc gcataatatt tcatgagaat     1260

tataacgcgg gtacctatca gaatgacatc gccctcatcg agatgaaaaa agacgggaat     1320

aaaaaggact gcgagctgcc gcgctctata cctgcgtgtg tcccctggag tccttatctt     1380

ttccaaccta acgatacgtg tatagtgagc ggctggggcc gggagaagga caatgaacga     1440

gttttttcct tgcaatgggg agaagtgaag cttatttcca attgttcaaa gttttatgga     1500

aatagatttt atgaaaaaga aatggagtgt gcgggcactt atgacgggtc aattgatgct     1560

tgcaaaggtg atagcggggg cccacttgtc tgcatggacg ctaacaacgt gacttatgtg     1620

tggggtgttg tgtcctgggg cgaaaactgt ggcaagcccg agtttcccgg cgtatacacc     1680

aaagtagcta attatttcga ctggattagt tatcatgttg ggcggccatt tatatcccag     1740

tataatgtct aa                                                         1752


<210>  23
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC133: CFI IDT - Manually optimised

<400>  23
atgaagctcc tgcacgtctt cttgctgttt ctctgtttcc acctgagatt ttgcaaagta       60

acttacacca gtcaagaaga cttggtcgag aagaaatgtc tcgccaaaaa gtatactcac      120

ctgagctgtg ataaagtgtt ctgtcagccg tggcagcgct gcattgaggg tacatgtgtc      180

tgtaaactgc cttatcagtg tccgaagaac ggcacggctg tctgtgctac taacagacgg      240

tcttttccta cttattgcca gcaaaagagt ttggaatgtc tccaccctgg taccaagttt      300

ctcaacaatg gcacctgtac tgctgaaggc aaattctccg tcagtctcaa gcatggtaac      360

actgattctg aagggatagt agaagtaaag ttggttgacc aggacaagac gatgttcata      420

tgcaagtcaa gctggtccat gcgcgaggcg aatgtcgctt gtcttgattt gggcttccag      480

caaggggcag acacacagag aagattcaaa ttgagcgacc tgagtataaa ttcaaccgag      540

tgcctccatg tacattgcag agggctcgag acttctcttg ctgagtgtac atttacgaag      600

aggcggacta tgggatatca ggactttgct gacgtagtgt gttatactca gaaagcagac      660

agtcctatgg atgacttttt ccaatgcgtc aacggcaaat acatcagtca aatgaaagcg      720

tgcgacggta tcaacgattg tggtgaccag tctgatgagc tttgctgtaa agcatgtcaa      780

ggaaaggggt tccattgcaa gagtggtgta tgtattccct cacaatatca gtgcaatggg      840

gaagtcgatt gcataacagg cgaggatgag gtgggctgcg cgggatttgc ttctgtggcg      900

caagaggaaa ctgagatcct tacagcggat atggacgccg aacgaagacg catcaaatct      960

ctccttccca aactttcatg cggcgtcaaa aaccgaatgc atatacgcag gaagagaatt     1020

gttgggggaa agcgggcaca gctgggcgac ctcccctggc aagttgcaat aaaggatgca     1080

agtgggataa cgtgcggggg catctacatc gggggctgct ggatcttgac tgccgctcac     1140

tgtcttagag cctctaagac ccatagatac caaatctgga caactgtagt tgactggata     1200

catccggacc ttaaacgcat agttattgaa tacgttgacc gcataatctt tcatgagaat     1260

tataacgcgg gcacatacca aaatgacatc gccctgatcg agatgaaaaa ggacgggaat     1320

aaaaaggact gcgagctgcc gcgctctata cctgcgtgtg tcccctggag tccttatctt     1380

ttccaaccta acgatacgtg tatagtgagc ggctggggcc gggagaagga caatgaacga     1440

gttttttcct tgcaatgggg agaagtgaag cttatttcca attgttcaaa gttttatgga     1500

aatagatttt atgaaaaaga aatggagtgt gcgggcactt atgacgggtc aattgatgct     1560

tgcaaaggtg atagcggggg cccacttgtc tgcatggacg ctaacaatgt gacttatgtg     1620

tggggtgttg tgtcctgggg cgaaaactgt ggcaagcccg agtttcccgg cgtatacacc     1680

aaagtagcta attatttcga ctggattagt tatcatgttg ggcggccatt tatatcccag     1740

tataatgtct aa                                                         1752


<210>  24
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC134: CFI JCat - Basic

<400>  24
atgaagctgc tgcacgtgtt cctgctgttc ctgtgcttcc acctgcgctt ctgcaaggtg       60

acctacacca gccaggagga cctggtggag aagaagtgcc tggccaagaa gtacacccac      120

ctgagctgcg acaaggtgtt ctgccagccc tggcagcgct gcatcgaggg cacctgcgtg      180

tgcaagctgc cctaccagtg ccccaagaac ggcaccgccg tgtgcgccac caaccgccgc      240

agcttcccca cctactgcca gcagaagagc ctggagtgcc tgcaccccgg caccaagttc      300

ctgaacaacg gcacctgcac cgccgagggc aagttcagcg tgagcctgaa gcacggcaac      360

accgacagcg agggcatcgt ggaggtgaag ctggtggacc aggacaagac catgttcatc      420

tgcaagagca gctggagcat gcgcgaggcc aacgtggcct gcctggacct gggcttccag      480

cagggcgccg acacccagcg ccgcttcaag ctgagcgacc tgagcatcaa cagcaccgag      540

tgcctgcacg tgcactgccg cggcctggag accagcctgg ccgagtgcac cttcaccaag      600

cgccgcacca tgggctacca ggacttcgcc gacgtggtgt gctacaccca gaaggccgac      660

agccccatgg acgacttctt ccagtgcgtg aacggcaagt acatcagcca gatgaaggcc      720

tgcgacggca tcaacgactg cggcgaccag agcgacgagc tgtgctgcaa ggcctgccag      780

ggcaagggct tccactgcaa gagcggcgtg tgcatcccca gccagtacca gtgcaacggc      840

gaggtggact gcatcaccgg cgaggacgag gtgggctgcg ccggcttcgc cagcgtggcc      900

caggaggaga ccgagatcct gaccgccgac atggacgccg agcgccgccg catcaagagc      960

ctgctgccca agctgagctg cggcgtgaag aaccgcatgc acatccgccg caagcgcatc     1020

gtgggcggca agcgcgccca gctgggcgac ctgccctggc aggtggccat caaggacgcc     1080

agcggcatca cctgcggcgg catctacatc ggcggctgct ggatcctgac cgccgcccac     1140

tgcctgcgcg ccagcaagac ccaccgctac cagatctgga ccaccgtggt ggactggatc     1200

caccccgacc tgaagcgcat cgtgatcgag tacgtggacc gcatcatctt ccacgagaac     1260

tacaacgccg gcacctacca gaacgacatc gccctgatcg agatgaagaa ggacggcaac     1320

aagaaggact gcgagctgcc ccgcagcatc cccgcctgcg tgccctggag cccctacctg     1380

ttccagccca acgacacctg catcgtgagc ggctggggcc gcgagaagga caacgagcgc     1440

gtgttcagcc tgcagtgggg cgaggtgaag ctgatcagca actgcagcaa gttctacggc     1500

aaccgcttct acgagaagga gatggagtgc gccggcacct acgacggcag catcgacgcc     1560

tgcaagggcg acagcggcgg ccccctggtg tgcatggacg ccaacaacgt gacctacgtg     1620

tggggcgtgg tgagctgggg cgagaactgc ggcaagcccg agttccccgg cgtgtacacc     1680

aaggtggcca actacttcga ctggatcagc taccacgtgg gccgcccctt catcagccag     1740

tacaacgtgt aa                                                         1752


<210>  25
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC135: CFI JCat - Manually optimised

<400>  25
atgaagctgc tccacgtgtt cctgctcttc ctgtgcttcc acctgcgctt ctgcaaggtg       60

acctacacca gccaggagga cctggtggag aagaaatgcc tggccaagaa atacacccac      120

ctgagctgcg acaaggtgtt ctgccagccc tggcagcgct gcatcgaggg cacctgcgtg      180

tgcaagctgc cctaccagtg ccccaagaac ggcaccgccg tgtgcgccac caaccgccgg      240

agcttcccca cctactgcca gcaaaagagc ctggagtgcc tgcaccccgg caccaagttc      300

ctgaacaatg gcacctgcac cgccgagggc aagttcagcg tgagcctgaa gcacggcaac      360

accgacagcg agggcatcgt ggaggtgaag ctggtggacc aggacaagac catgttcatc      420

tgcaagagct cctggagcat gcgcgaggcc aacgtggcct gcctggacct gggcttccag      480

caaggcgccg acacccagcg ccggttcaag ctgagcgacc tgagcatcaa cagcaccgag      540

tgcctgcacg tgcactgccg cggcctggag accagcctgg ccgagtgcac cttcaccaag      600

cgccggacca tgggctacca ggacttcgcc gacgtggtct gctacaccca gaaggctgac      660

tctcccatgg acgatttctt tcagtgcgtg aacggcaagt acatcagcca gatgaaggcc      720

tgcgacggca tcaacgactg cggcgaccag agcgacgagc tgtgctgtaa ggcctgccag      780

ggcaagggct tccactgcaa gagcggcgtg tgcatcccca gccagtacca gtgcaacggc      840

gaggtggact gcatcaccgg cgaggacgag gtgggctgcg ccggcttcgc cagcgtggcc      900

caggaggaaa ccgagatcct gaccgccgac atggacgccg agcgcagaag gatcaagagc      960

ctgctcccca agctgagctg cggcgtgaag aaccgcatgc acatccgcag aaagcgcatc     1020

gtgggcggga agcgcgccca gctgggcgac ctgccctggc aggtggccat caaggacgcc     1080

agcggcatca cctgcggcgg aatctacatc ggcgggtgct ggatcctgac cgccgctcac     1140

tgcctgcgcg ccagcaagac ccaccgctac cagatctgga ccacagtggt cgactggatc     1200

caccccgacc tgaagcgcat cgtgatcgag tacgtggacc gcatcatttt ccacgagaac     1260

tacaacgccg gcacctacca gaacgacatc gccctgatcg agatgaagaa agatggaaac     1320

aagaaagact gcgagctgcc ccgcagcatc cccgcctgcg tgccctggag cccctacctg     1380

ttccagccca acgacacctg catcgtgagc ggctggggcc gcgagaagga caacgagcgc     1440

gtgttcagcc tgcagtgggg cgaggtgaag ctgatcagca actgcagcaa gttctacggc     1500

aaccgcttct acgagaagga gatggagtgc gccggcacct acgacggcag catcgacgcc     1560

tgcaagggcg acagcggcgg gcccctggtg tgcatggacg ccaacaatgt gacctacgtg     1620

tggggcgtgg tcagctgggg cgagaactgc ggcaagcccg agttccccgg cgtgtacacc     1680

aaggtggcca actacttcga ctggatcagc taccacgtgg gccgcccctt tatctctcaa     1740

tacaacgtct aa                                                         1752


<210>  26
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC137: CFI COOL - Manually optimised

<400>  26
atgaaactgc tccatgtctt cctcctgttc ctgtgcttcc acctccgttt ctgtaaagtc       60

acctacacta gccaggagga tctggtggag aagaaatgcc tggccaagaa atatacccac      120

ctgagctgcg acaaagtgtt ctgccagccc tggcaacgct gcattgaagg cacttgtgtg      180

tgcaagctgc cctaccagtg ccccaagaac ggcacggccg tgtgtgccac caacaggaga      240

agcttcccca cctactgcca gcaaaagagc ctggaatgcc tccaccctgg caccaagttt      300

ctgaacaatg ggacctgcac agccgagggg aaattcagcg tctccctcaa gcacggcaat      360

acagactccg agggcattgt ggaagtgaag ctggtggacc aggacaagac catgttcatc      420

tgcaaaagct cctggtccat gcgggaggcc aatgtcgcct gcctggacct gggcttccag      480

caaggcgctg atacacagcg cagatttaaa ctcagtgacc tcagcatcaa cagcactgag      540

tgtctgcacg tgcactgccg gggcctggag accagcctgg ctgagtgcac cttcaccaag      600

cgcaggacca tgggctacca ggattttgca gatgtggtct gctacaccca gaaggcagac      660

agccccatgg atgacttctt tcagtgtgtc aatggcaagt acatttccca gatgaaggct      720

tgtgacggga tcaatgattg cggggatcag agcgatgagc tctgctgtaa ggcctgccaa      780

gggaagggct ttcactgcaa gtctggggtg tgcatccctt ctcagtatca gtgcaacgga      840

gaggtggact gcatcactgg ggaggacgag gtgggctgtg ctggcttcgc ctctgtggcc      900

caggaggaaa cagagatcct cacagctgac atggatgcag agcggaggcg catcaagagt      960

ctgctcccaa agctctcctg cggcgttaag aatcgcatgc acatccggag gaagcggatc     1020

gttggaggca aacgggctca gctgggggac ttgccgtggc aggtggccat caaagatgcc     1080

tccggaatca cctgtggtgg catctacatc ggcgggtgct ggatcctgac cgccgctcac     1140

tgccttcggg ccagcaagac ccatcgctac cagatctgga ccacagtggt cgattggatt     1200

caccccgacc tgaagaggat tgtcattgag tatgtcgacc gcatcatttt ccatgaaaac     1260

tacaatgccg ggacgtatca gaacgacatc gccctcatcg agatgaagaa agatgggaac     1320

aagaaagact gtgagctgcc tcgctccatc cccgcctgtg taccatggtc tccgtacctg     1380

ttccagccaa atgacacatg catcgtgagc ggctggggcc gcgagaaaga caacgagagg     1440

gtcttctccc tgcagtgggg tgaagtcaag ctgatcagca actgctccaa gttctacggc     1500

aaccgcttct atgagaagga gatggagtgc gccggcacct atgacggcag cattgacgcg     1560

tgcaagggag acagtggggg ccccctggtc tgcatggacg ccaacaatgt gacctacgtg     1620

tggggagttg tgtcctgggg cgagaactgt ggcaagcctg agttcccggg cgtgtacaca     1680

aaggtggcaa actattttga ctggatctcc tatcacgttg gcaggccctt cattagccag     1740

tataatgtat aa                                                         1752


<210>  27
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC138: FHL-1 GeneArt - Basic

<400>  27
atgagactgc tggccaagat catctgcctg atgctgtggg ccatctgcgt ggccgaggat       60

tgcaatgagc tgcctcctcg gagaaacacc gagatcctga caggctcttg gagcgaccag      120

acataccctg agggaaccca ggccatctac aagtgcagac ccggctacag aagcctgggc      180

aacatcatca tggtctgccg gaaaggcgag tgggtcgccc tgaatcctct gcggaagtgc      240

cagaaaagac cctgcggaca ccctggcgat acccctttcg gaacctttac actgaccggc      300

ggcaacgtgt tcgagtacgg cgtgaaagcc gtgtacacct gtaacgaggg ctaccagctg      360

ctgggcgaga tcaactacag agagtgcgat accgacggct ggaccaacga catccctatc      420

tgcgaggtgg tcaagtgcct gcctgtgaca gcccctgaga acggcaagat tgtgtccagc      480

gccatggaac ccgacagaga gtaccacttt ggccaggccg tcagattcgt gtgcaacagc      540

ggctacaaga tcgagggcga cgaggaaatg cactgcagcg acgatggctt ctggtccaaa      600

gaaaagccta agtgcgtgga aatcagctgc aagagccccg acgtgatcaa cggcagccct      660

atcagccaga agattatcta caaagagaac gagcggttcc agtacaagtg taacatgggc      720

tacgagtaca gcgagagggg cgacgccgtg tgtacagaat ctggatggcg acctctgcct      780

agctgcgagg aaaagagctg cgacaaccct tacatcccca acggcgacta cagcccactg      840

cggatcaaac acagaaccgg cgacgagatc acctaccagt gccggaatgg cttctaccct      900

gccaccagag gcaataccgc caagtgtaca agcaccggct ggatccctgc tcctcggtgt      960

acactgaagc cctgcgacta ccccgatatc aagcacggcg gactgtacca cgagaacatg     1020

cggaggcctt acttccctgt ggccgtgggc aagtactaca gctactactg cgacgagcac     1080

ttcgagacac ccagcggcag ctactgggat cacatccact gtacccagga cggctggtca     1140

ccagctgtgc cttgcctgag aaagtgctac ttcccctacc tggaaaacgg ctacaaccag     1200

aactacggcc ggaagttcgt gcagggcaag agcatcgatg tggcctgcca tcctggatac     1260

gccctgccta aggctcagac caccgtgacc tgcatggaaa atggctggtc cccaacacct     1320

cggtgcatcc gggtgtcctt cacactgtaa                                      1350


<210>  28
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC139: FHL-1 GeneArt - Manually optimised

<400>  28
atgagactgc tcgccaagat catttgcctg atgctgtggg ccatctgcgt ggccgaggat       60

tgcaatgagc tgcctccccg gagaaacacc gagatcctga caggctcttg gagcgaccag      120

acataccctg agggaaccca ggccatctac aagtgcagac ccggctacag aagcctgggc      180

aacatcatta tggtctgccg gaaaggcgag tgggtcgccc tgaatcctct gcggaagtgc      240

cagaaaagac cctgcggaca ccctggcgat acccctttcg gaacctttac actgaccggc      300

gggaacgtgt tcgagtacgg cgtgaaagcc gtgtacacct gtaacgaggg ctaccagctg      360

ctcggcgaga tcaactacag agagtgcgat accgacggct ggaccaacga catccctatc      420

tgcgaggtgg tcaagtgcct gcctgtgaca gcccctgaga acggcaagat tgtgtccagc      480

gccatggaac ccgacagaga gtaccacttt ggccaggccg tcagattcgt gtgcaacagc      540

ggctacaaga tcgagggcga cgaggaaatg cactgcagcg acgatggctt ctggtccaaa      600

gaaaagccta agtgcgtgga aatcagctgc aagagccccg acgtgatcaa cggcagccct      660

atcagccaga agattatcta caaagagaac gagcggttcc agtacaagtg taacatgggc      720

tacgagtaca gcgagagggg cgacgccgtg tgtacagaat ctggatggcg acctctgcct      780

agctgcgagg aaaagagctg cgacaaccct tacatcccca acggcgacta cagcccactg      840

cggatcaaac acagaaccgg cgacgagatc acctaccagt gccggaatgg cttctaccct      900

gccaccagag gcaataccgc caagtgtaca agcaccggct ggatccctgc tcctcggtgt      960

acactgaagc cctgcgacta ccccgatatc aagcacggcg gactgtacca cgagaacatg     1020

cggaggcctt acttccctgt ggccgtgggc aagtactata gctactattg cgacgagcac     1080

ttcgagacac ccagcggcag ctactgggat cacatccact gtacccagga cggctggtca     1140

ccagctgtgc cttgcctgag aaagtgctac ttcccctacc tggaaaacgg ctacaaccag     1200

aactacggcc ggaagttcgt gcagggcaag agcatcgatg tggcctgcca tcctggatac     1260

gccctgccta aggctcagac cacagtgacc tgcatggaaa atggctggtc cccaacacct     1320

cggtgcatcc gggtgtcctt cacactgtaa                                      1350


<210>  29
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC140: FHL-1 Genscript - Basic

<400>  29
atgcggctgc tggccaagat catctgcctg atgctgtggg ccatctgcgt ggccgaggac       60

tgtaacgagc tgccccctcg gagaaataca gagatcctga ccggctcttg gagcgatcag      120

acatatcctg agggcaccca ggccatctac aagtgcaggc caggctatcg ctccctgggc      180

aacatcatca tggtgtgcag gaagggagag tgggtggccc tgaatcctct gaggaagtgc      240

cagaagaggc catgtggaca cccaggcgac acccctttcg gcacctttac actgaccggc      300

ggcaacgtgt tcgagtacgg cgtgaaggcc gtgtatacat gcaacgaggg ctaccagctg      360

ctgggcgaga tcaattacag agagtgtgac acagatggct ggaccaacga tatcccaatc      420

tgcgaggtgg tgaagtgtct gccagtgacc gcccccgaga atggcaagat cgtgagctcc      480

gccatggagc ccgacaggga gtatcacttc ggccaggccg tgcgcttcgt gtgcaactct      540

ggctacaaga tcgagggcga tgaggagatg cactgtagcg acgatggctt ctggtccaag      600

gagaagccca agtgcgtgga gatcagctgt aagtccccag acgtgatcaa tggctctccc      660

atcagccaga agatcatcta taaggagaac gagaggtttc agtacaagtg caatatgggc      720

tacgagtatt ccgagagggg cgatgccgtg tgcaccgagt ctggctggag accactgccc      780

tcctgcgagg agaagtcttg tgacaaccca tatatcccca atggcgatta ctctcccctg      840

cggatcaagc acagaacagg cgacgagatc acctatcagt gccggaacgg cttctaccct      900

gccacaagag gcaataccgc caagtgtaca agcaccggat ggatccctgc accaaggtgc      960

accctgaagc cttgtgacta tccagatatc aagcacggcg gcctgtatca cgagaatatg     1020

aggcgccctt acttcccagt ggccgtgggc aagtactata gctactattg cgacgagcac     1080

tttgagaccc cttccggctc ttactgggac cacatccact gtacacagga tggatggtcc     1140

ccagcagtgc cttgcctgag gaagtgttac ttcccatatc tggagaacgg ctacaaccag     1200

aattatggcc gcaagtttgt gcagggcaag agcatcgatg tggcatgcca cccaggatac     1260

gcactgccta aggcacagac cacagtgaca tgcatggaga atggctggtc tcccacccct     1320

cggtgtatca gagtgagctt tacactgtga                                      1350


<210>  30
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC141: FHL-1 Genscript - Manually optimised

<400>  30
atgcggctgc tcgccaagat catttgcctg atgctgtggg ccatctgcgt ggccgaggac       60

tgtaacgagc tgccccctcg gagaaataca gagatcctga ccggctcttg gagcgatcag      120

acatatcctg agggcaccca ggccatctac aagtgcaggc caggctatcg ctccctgggc      180

aacatcatta tggtgtgcag gaagggagag tgggtggccc tgaatcctct gaggaagtgc      240

cagaagaggc catgtggaca cccaggcgac acccctttcg gcacctttac actgaccggc      300

gggaacgtgt tcgagtacgg cgtgaaggcc gtgtatacat gcaacgaggg ctaccagctg      360

ctcggcgaga tcaattacag agagtgtgac acagatggct ggaccaacga tatcccaatc      420

tgcgaggtgg tcaagtgtct gccagtgacc gcccccgaga atggcaagat cgtgagctcc      480

gccatggagc ccgacaggga gtatcacttc ggccaggccg tgcgcttcgt gtgcaactct      540

ggctacaaga tcgagggcga tgaggaaatg cactgtagcg acgatggctt ctggtccaag      600

gagaagccca agtgcgtgga gatcagctgc aagtccccag acgtgatcaa tggctctccc      660

atcagccaga agatcattta taaggagaac gagaggtttc agtacaagtg caatatgggc      720

tacgagtatt ccgagagggg cgatgccgtg tgcaccgagt ctggctggag accactgccc      780

tcctgcgagg aaaagtcttg tgacaaccca tatatcccca atggcgatta ctctcccctg      840

cggatcaagc acagaacagg cgacgagatc acctatcagt gccggaacgg cttctaccct      900

gccacaagag gcaataccgc caagtgtaca agcaccggat ggatccctgc accaaggtgc      960

accctgaagc cttgtgacta tccagatatc aagcacggcg ggctgtatca cgagaatatg     1020

aggcgccctt acttcccagt ggccgtgggc aagtactata gctactattg cgacgagcac     1080

tttgagaccc cttccggctc ttactgggac cacatccact gtacacagga tggatggtcc     1140

ccagcagtgc cttgcctgag gaagtgttac ttcccatatc tggagaacgg ctacaaccag     1200

aattatggcc gcaagtttgt gcagggcaag agcatcgatg tggcatgcca cccaggatac     1260

gcactgccta aggcacagac cacagtgaca tgcatggaga atggctggtc tcccacccct     1320

cggtgtatca gagtgagctt tacactgtga                                      1350


<210>  31
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC142: FHL-1 IDT - Basic

<400>  31
atgagactgc ttgcgaaaat tatatgcctg atgctttggg ctatttgcgt tgcggaagac       60

tgtaacgaac tcccgccccg ccgaaataca gagatcctca caggcagttg gagcgaccaa      120

acgtaccctg aaggtacgca ggccatatat aagtgtaggc caggctacag atcacttggt      180

aacataataa tggtatgtcg gaaaggagag tgggtcgctc tcaaccctct taggaaatgt      240

caaaaaagac cctgtgggca tccgggagat acgcctttcg ggacattcac tctcacgggc      300

ggaaacgtat tcgaatatgg cgtgaaggca gtgtatacct gcaatgaagg gtatcagctg      360

cttggggaaa ttaattatag ggaatgtgac acggatgggt ggacaaacga tattccaata      420

tgcgaagtag ttaaatgcct gcccgttact gcaccggaga atggcaaaat agtcagtagt      480

gcaatggagc cggatcgcga gtatcatttt ggtcaggccg tgcggttcgt atgtaattct      540

gggtacaaga tcgaaggtga cgaagagatg cattgctcag atgacggctt ttggagtaaa      600

gaaaagccta agtgtgttga aatcagctgt aagagtccag acgtgattaa cggttccccg      660

atctctcaga agataattta caaggaaaac gaacgattcc aatataagtg taacatgggc      720

tacgagtatt ccgagcgagg tgacgcagta tgtacggaaa gcgggtggcg acctctgccc      780

tcctgcgagg aaaagagctg tgataatccg tatatcccca acggtgacta tagcccactg      840

cgcataaaac atcggacggg agatgagatt acataccaat gccgcaatgg tttttacccc      900

gccacccgag ggaacacggc aaagtgcact tctacggggt ggattccagc tcctaggtgc      960

actcttaaac cctgcgacta cccagatatc aagcatggtg gactgtatca tgagaatatg     1020

aggagaccat actttccagt tgcagtgggc aagtactata gctattactg tgatgagcac     1080

tttgaaactc cgtctgggag ctactgggat catatccatt gtacgcaaga cggctggagt     1140

ccagcagttc catgcttgcg gaaatgttat tttccctacc tcgaaaacgg atataatcag     1200

aactatggga ggaagtttgt tcaaggcaaa agcattgatg tggcatgtca ccccggttat     1260

gccctgccca aggcgcaaac cacagtaact tgcatggaga atggatggag ccccacaccc     1320

agatgtatac gagtatcctt cacgctttga                                      1350


<210>  32
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC143: FHL-1 IDT - Manually optimised

<400>  32
atgagactgc ttgcgaaaat tatatgcctg atgctttggg ctatttgcgt tgcggaagac       60

tgtaacgaac tcccgccccg ccgaaataca gagatcctca caggcagttg gagcgaccaa      120

acgtaccctg aaggcacgca ggccatatat aagtgtaggc caggctacag atcacttggt      180

aacataatca tggtgtgtcg gaaaggagag tgggtcgctc tcaaccctct tcgcaaatgt      240

caaaaaagac cctgtgggca tccgggagat acgcctttcg ggacattcac tctcacgggc      300

ggaaacgtat tcgaatatgg cgtgaaggca gtgtatacct gcaatgaagg gtatcagctg      360

cttggggaaa ttaattatag ggaatgtgac acggatgggt ggacaaacga tattccaata      420

tgcgaagtag ttaaatgcct gcccgttact gcaccggaga atggcaaaat agtcagtagc      480

gcaatggagc cggatcgcga gtatcatttt ggtcaggccg tgcggttcgt atgtaattct      540

gggtacaaga tcgaaggtga cgaagagatg cattgctcag atgacggctt ttggagcaag      600

gaaaagccta agtgtgttga aatcagctgt aagagtccag acgtgattaa cggttccccg      660

atctctcaga agataattta caaggaaaac gaacgattcc aatataagtg taacatgggc      720

tacgagtatt ccgagcgagg tgacgcagta tgtacggaaa gcgggtggcg acctctgccc      780

tcctgcgagg aaaagagctg tgataatccg tatatcccca acggcgacta tagcccactg      840

cgcataaaac atcggacggg agatgagatt acataccaat gccgcaatgg tttttacccc      900

gccacccgag ggaacacggc aaagtgcact tctacggggt ggattccagc tcctaggtgc      960

actcttaaac cctgcgacta cccagatatc aagcatggtg gactgtatca tgagaatatg     1020

aggagaccat actttccagt tgcagtgggc aagtactata gctattactg tgatgagcac     1080

tttgaaactc cgtctgggag ctactgggat catatccatt gtacgcaaga cggctggagt     1140

ccagcagttc catgcttgcg gaaatgttat tttccctacc tcgaaaacgg atataatcag     1200

aattacggca ggaaatttgt gcaaggcaaa agcattgatg tggcatgtca ccccggttat     1260

gccctgccca aggcgcaaac cacagtaact tgcatggaga atggatggag ccccacaccc     1320

agatgtatac gagtatcctt cacgctttga                                      1350


<210>  33
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC144: FHL-1 JCat - Basic

<400>  33
atgcgcctgc tggccaagat catctgcctg atgctgtggg ccatctgcgt ggccgaggac       60

tgcaacgagc tgcccccccg ccgcaacacc gagatcctga ccggcagctg gagcgaccag      120

acctaccccg agggcaccca ggccatctac aagtgccgcc ccggctaccg cagcctgggc      180

aacatcatca tggtgtgccg caagggcgag tgggtggccc tgaaccccct gcgcaagtgc      240

cagaagcgcc cctgcggcca ccccggcgac acccccttcg gcaccttcac cctgaccggc      300

ggcaacgtgt tcgagtacgg cgtgaaggcc gtgtacacct gcaacgaggg ctaccagctg      360

ctgggcgaga tcaactaccg cgagtgcgac accgacggct ggaccaacga catccccatc      420

tgcgaggtgg tgaagtgcct gcccgtgacc gcccccgaga acggcaagat cgtgagcagc      480

gccatggagc ccgaccgcga gtaccacttc ggccaggccg tgcgcttcgt gtgcaacagc      540

ggctacaaga tcgagggcga cgaggagatg cactgcagcg acgacggctt ctggagcaag      600

gagaagccca agtgcgtgga gatcagctgc aagagccccg acgtgatcaa cggcagcccc      660

atcagccaga agatcatcta caaggagaac gagcgcttcc agtacaagtg caacatgggc      720

tacgagtaca gcgagcgcgg cgacgccgtg tgcaccgaga gcggctggcg ccccctgccc      780

agctgcgagg agaagagctg cgacaacccc tacatcccca acggcgacta cagccccctg      840

cgcatcaagc accgcaccgg cgacgagatc acctaccagt gccgcaacgg cttctacccc      900

gccacccgcg gcaacaccgc caagtgcacc agcaccggct ggatccccgc cccccgctgc      960

accctgaagc cctgcgacta ccccgacatc aagcacggcg gcctgtacca cgagaacatg     1020

cgccgcccct acttccccgt ggccgtgggc aagtactaca gctactactg cgacgagcac     1080

ttcgagaccc ccagcggcag ctactgggac cacatccact gcacccagga cggctggagc     1140

cccgccgtgc cctgcctgcg caagtgctac ttcccctacc tggagaacgg ctacaaccag     1200

aactacggcc gcaagttcgt gcagggcaag agcatcgacg tggcctgcca ccccggctac     1260

gccctgccca aggcccagac caccgtgacc tgcatggaga acggctggag ccccaccccc     1320

cgctgcatcc gcgtgagctt caccctgtaa                                      1350


<210>  34
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC145: FHL-1 JCat - Manually optimised

<400>  34
atgcgcctgc tcgccaagat catttgcctg atgctgtggg ccatctgcgt ggccgaggac       60

tgcaacgagc tgccccctcg ccggaacacc gagatcctga ccggcagctg gagcgaccag      120

acctaccccg agggcaccca ggccatctac aagtgccgcc ccggctaccg cagcctgggc      180

aacatcatta tggtgtgccg caagggcgag tgggtggccc tgaaccccct gcgcaagtgc      240

cagaagcgcc cctgcggcca ccccggcgac acccccttcg gcaccttcac cctgaccggc      300

ggcaacgtgt tcgagtacgg cgtgaaggcc gtgtacacct gcaacgaggg ctaccagctg      360

ctcggcgaga tcaactaccg cgagtgcgac accgacggct ggaccaacga catccccatc      420

tgcgaggtgg tcaagtgcct gcccgtgacc gcccccgaga acggcaagat cgtgagctcc      480

gccatggagc ccgaccgcga gtaccacttc ggccaggccg tgcgcttcgt gtgcaacagc      540

ggctacaaga tcgagggcga cgaggagatg cactgcagcg acgatggctt ctggagcaag      600

gagaagccca agtgcgtgga gatcagctgc aagagccccg acgtgatcaa cggcagcccc      660

atcagccaga agatcattta caaggagaac gagcgcttcc agtacaagtg caacatgggc      720

tacgagtaca gcgagcgcgg cgacgccgtg tgcaccgaga gcggctggcg ccccctgccc      780

agctgcgagg aaaagagctg cgacaacccc tacatcccca acggcgacta cagccccctg      840

cgcatcaagc accgcaccgg cgacgagatc acctaccagt gccgcaacgg cttctacccc      900

gccacccgcg gcaacaccgc caagtgcacc agcaccggct ggatccccgc cccccgctgc      960

accctgaagc cctgcgacta ccccgacatc aagcacggcg ggctgtacca cgagaacatg     1020

cgccggccct acttccccgt ggccgtgggc aagtactata gctactattg cgacgagcac     1080

ttcgagaccc ccagcggcag ctactgggac cacatccact gcacccagga cggctggagc     1140

cccgccgtgc cctgcctgcg caagtgctac ttcccctacc tggagaacgg ctacaaccag     1200

aactacggcc gcaagttcgt gcagggcaag agcatcgacg tggcctgcca ccccggctac     1260

gccctgccca aggcccagac cacagtgacc tgcatggaga acggctggag ccccaccccc     1320

cgctgcatcc gcgtgagctt caccctgtaa                                      1350


<210>  35
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RC147: FHL-1 COOL - Manually optimised

<400>  35
atgcgcctcc tggccaagat catttgcctc atgctgtggg ccatctgcgt ggctgaggac       60

tgcaatgagc tgccgcccag gagaaacaca gagatcctga cagggagctg gtctgaccag      120

acctaccctg agggcaccca ggcgatctac aagtgccggc cgggctacag gagcctgggg      180

aacatcatta tggtgtgtag aaagggcgaa tgggtggccc tcaaccccct gaggaagtgc      240

cagaagcggc cctgtggcca ccccggggac acacccttcg ggaccttcac cctgaccggc      300

gggaatgtgt ttgagtacgg cgtgaaggct gtctacacat gcaacgaggg gtaccagctg      360

ctcggcgaga ttaactaccg ggagtgtgac accgatgggt ggaccaacga cattcccatc      420

tgtgaggtgg tcaagtgtct ccccgtgaca gccccagaaa atggcaaaat tgtgagctcc      480

gccatggagc ctgaccgcga atatcacttt gggcaggccg tgaggtttgt gtgcaactcg      540

ggctacaaaa ttgaaggtga tgaggaaatg cactgcagcg atgacggctt ctggtccaag      600

gagaagccca aatgtgtgga gatctcctgc aagtctcccg acgtgatcaa cggcagccca      660

atcagccaga agattatcta caaagagaac gagcgcttcc agtacaagtg taacatgggc      720

tatgagtatt cagagagggg agatgccgtc tgcactgaga gcggctggag accactgcct      780

agctgcgagg aaaagagttg tgacaaccct tacatcccaa atggcgacta ctcccctctg      840

cggatcaaac accggaccgg ggatgaaatc acctatcagt gccgcaatgg attctacccg      900

gccacccgcg gcaacaccgc caaatgcacc agcacaggct ggatccccgc cccccgctgt      960

acgctgaagc cttgcgacta tccagacatc aagcacggag gcctgtacca cgaaaacatg     1020

cggaggcctt atttccctgt ggcagtgggg aagtactata gctactattg cgacgagcac     1080

ttcgagaccc cctctggctc ctactgggac cacatccact gcacacagga cggctggtct     1140

ccagctgtgc cctgcctgag gaaatgctac ttcccctacc tggagaacgg atacaaccag     1200

aactatggcc gcaagttcgt gcagggcaag agcatcgatg tggcctgcca ccctggctac     1260

gccctgccca aggcccagac aactgtgacc tgcatggaga atggttggag ccccaccccg     1320

cgctgcatcc gggtgtcctt cacgctctga                                      1350


