                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
 
<120>  Modified antibodies

<130>  P262167WO

<150>  GB1820547.6
<151>  2018-12-17

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  457
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (31)..(35)
<223>  Position of CDR1

<220>
<221>  MISC_FEATURE
<222>  (50)..(66)
<223>  Position of CDR2

<220>
<221>  MISC_FEATURE
<222>  (99)..(116)
<223>  Position of CDR3

<220>
<221>  MISC_FEATURE
<222>  (128)..(225)
<223>  Position of CH1

<220>
<221>  MISC_FEATURE
<222>  (226)..(240)
<223>  Position of hinge

<220>
<221>  MISC_FEATURE
<222>  (241)..(350)
<223>  Position of CH2

<220>
<221>  MISC_FEATURE
<222>  (241)..(249)
<223>  Position of the Fc receptor binding regions

<220>
<221>  MISC_FEATURE
<222>  (274)..(280)
<223>  Position of the Fc receptor binding regions

<220>
<221>  MISC_FEATURE
<222>  (304)..(309)
<223>  Position of the Fc receptor binding regions

<220>
<221>  MISC_FEATURE
<222>  (335)..(342)
<223>  Position of the Fc receptor binding regions

<220>
<221>  MISC_FEATURE
<222>  (351)..(457)
<223>  Position of CH3

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Gln Ala Ser Gly Tyr Arg Phe Ser Asn Phe 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Tyr Asn Gly Asn Lys Glu Phe Ser Ala Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Phe Thr Ala Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Tyr Ser Trp Asp Asp Ser Pro Gln Asp Asn Tyr 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Ile Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  2
<211>  444
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (31)..(35)
<223>  Position of CDR1

<220>
<221>  MISC_FEATURE
<222>  (50)..(66)
<223>  Position of CDR2

<220>
<221>  MISC_FEATURE
<222>  (99)..(109)
<223>  Position of CDR3

<220>
<221>  MISC_FEATURE
<222>  (121)..(217)
<223>  Position of CH1

<220>
<221>  MISC_FEATURE
<222>  (218)..(230)
<223>  Position of hinge

<220>
<221>  MISC_FEATURE
<222>  (231)..(337)
<223>  Position of CH2

<220>
<221>  MISC_FEATURE
<222>  (262)..(262)
<223>  Position of the Fc receptor binding region

<220>
<221>  MISC_FEATURE
<222>  (338)..(444)
<223>  Position of CH3

<400>  2

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Leu Tyr Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Asp Tyr Arg Tyr Asp Arg Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
            180                 185                 190         


Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
    210                 215                 220                 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
    290                 295                 300                 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
305                 310                 315                 320 


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
            340                 345                 350         


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
        355                 360                 365             


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
    370                 375                 380                 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser 
385                 390                 395                 400 


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
                405                 410                 415     


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
            420                 425                 430         


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 


<210>  3
<211>  50
<212>  PRT
<213>  Mus musculus

<400>  3

Arg Thr Thr Met Leu Pro Ser Thr Pro His Ile Thr Ala Pro Ser Thr 
1               5                   10                  15      


Ser Glu Ala Gln Asn Ala Ser Pro Ser Val Ser Val Gly Ser Gly Thr 
            20                  25                  30          


Val Asp Ser Lys Glu Thr Ile Ser Pro Trp Gly Gln Thr Thr Ile Pro 
        35                  40                  45              


Val Ser 
    50  


<210>  4
<211>  30
<212>  PRT
<213>  Mus musculus

<400>  4

Arg Thr Thr Met Leu Pro Ser Thr Pro His Ile Thr Ala Pro Ser Thr 
1               5                   10                  15      


Ser Glu Ala Gln Asn Ala Ser Pro Ser Val Ser Val Gly Ser 
            20                  25                  30  


<210>  5
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Thr Thr Ala Val Gln Thr Pro Thr Ser Gly Glu Pro Leu Val Ser 
1               5                   10                  15      


Thr Ser Glu Pro Leu Ser Ser Lys Met Tyr Thr Thr Ser Ile Thr Ser 
            20                  25                  30          


Asp Pro Lys Ala Asp Ser Thr Gly Asp Gln Thr Ser Ala Leu Pro Pro 
        35                  40                  45              


Ser Thr 
    50  


<210>  6
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Thr Thr Ala Val Gln Thr Pro Thr Ser Gly Glu Pro Leu Val Ser 
1               5                   10                  15      


Thr Ser Glu Pro Leu Ser Ser 
            20              


<210>  7
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide insert incorporating sequence derived from 
       mouse CD43 flanked by hinge sequence

<400>  7

Val Pro Arg Asp Cys Gly Ser Arg Thr Thr Met Leu Pro Ser Thr Pro 
1               5                   10                  15      


His Ile Thr Ala Pro Ser Thr Ser Glu Ala Gln Asn Ala Ser Pro Ser 
            20                  25                  30          


Val Ser Val Gly Ser Gly Thr Val Asp Ser Lys Glu Thr Ile Ser Pro 
        35                  40                  45              


Trp Gly Gln Thr Thr Ile Pro Val Ser Gly Ser Gly Cys Lys Pro Cys 
    50                  55                  60                  


Ile Cys Thr 
65          


<210>  8
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide insert incorporating sequence derived from 
       mouse CD43 flanked by hinge sequence

<400>  8

Val Pro Arg Asp Cys Gly Ser Arg Thr Thr Met Leu Pro Ser Thr Pro 
1               5                   10                  15      


His Ile Thr Ala Pro Ser Thr Ser Glu Ala Gln Asn Ala Ser Pro Ser 
            20                  25                  30          


Val Ser Val Gly Ser Gly Ser Gly Cys Lys Pro Cys Ile Cys Thr 
        35                  40                  45          


