                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
       MiroBio Limited
 
<120>  BTLA antibodies

<130>  P266301WO

<150>  GB1820554.2
<151>  2018-12-17

<160>  390   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  1

Gly Asp Ser Ile Thr Ser Ala Tyr 
1               5               


<210>  2
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  2

Ile Ser Tyr Ser Gly Ser Thr 
1               5           


<210>  3
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  3

Ala Arg Ser His Tyr Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  4
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  4

Glu Thr Ile Asp Ser Tyr Gly Asp Ser Leu 
1               5                   10  


<210>  5
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  5

Arg Ala Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Gln Thr Asp Glu Asp Pro Tyr Thr 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Phe Ser Leu Thr Thr Tyr Gly 
1               5               


<210>  8
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  8

Met Trp Pro Gly Gly Arg Thr 
1               5           


<210>  9
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  9

Val Arg Gly Asp Tyr Glu Tyr Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  10
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  10

Ser Ser Val Ser Tyr 
1               5   


<210>  11
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  11

Ala Thr Ser 
1           


<210>  12
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  12

His Gln Trp Ser Ser Asn Pro Tyr Thr 
1               5                   


<210>  13
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised antibody 2.8.6 VH region

<400>  13

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Trp Pro Gly Gly Arg Thr Ser Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Arg Gly Asp Tyr Glu Tyr Asp Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  14
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanised antibody 2.8.6 VL region

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Asn Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  15
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  15

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Asn Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  16
<211>  319
<212>  DNA
<213>  Mus musculus

<400>  16
caaattgttc tctcccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacttgca gggccagttc aagtgtaagt tacatgcact ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatgccaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagaat ggaggctgaa      240

gatgctgcca cttattactg ccaccagtgg agtagtaacc cgtacacgtt cggagggggg      300

accaagctgg aaataaaac                                                   319


<210>  17
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  17

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Trp Pro Gly Gly Arg Thr Ser Tyr Asn Pro Ala Pro Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Val 
                85                  90                  95      


Arg Gly Asp Tyr Glu Tyr Asp Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  361
<212>  DNA
<213>  Mus musculus

<400>  18
caggtgcagc tgaaggagtc tggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc acctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggagta atgtggcctg gtggaagaac aagttataat      180

ccggctccca tgtccagact gagcatcagc aaagacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacacg gccatgtact actgtgtcag aggggactat      300

gaatacgatt actatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360

g                                                                      361


<210>  19
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  19

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Thr Ile Asp Ser Tyr 
            20                  25                  30          


Gly Asp Ser Leu Met His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr Asp 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  20
<211>  333
<212>  DNA
<213>  Mus musculus

<400>  20
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aactattgat agttatggcg atagtttaat gcactggtac      120

cagcagaaag caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctcggacag acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctat tactgtcagc aaactgatga ggatccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  21
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  21

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Ala 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Phe Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asn Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser His Tyr Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly His Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  22
<211>  354
<212>  DNA
<213>  Mus musculus

<400>  22
gaggtgcagc ttcaggagtc aggacctagc ctcgtgaaac cttctcagac tctgtccctc       60

acctgttctg tcactggcga ctccatcacc agtgcttact ggaactggat ccggaaattc      120

ccagggaata aacttgagta catggggtac ataagctaca gtggtagcac ttacttcaat      180

ccatctctca aaagtcgaat ctccatcact cgaaacacat ccaagaacca gtactacctg      240

cagttgaatt ctgtgactac tgaggacaca gccacatatt actgtgcaag atctcattac      300

tacggctact actttgacta ctggggccat ggcaccactc tcacagtctc ctca            354


<210>  23
<211>  289
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(30)
<223>  signal sequence

<220>
<221>  MISC_FEATURE
<222>  (31)..(151)
<223>  extracellular region

<220>
<221>  MISC_FEATURE
<222>  (152)..(178)
<223>  transmembrane region

<220>
<221>  MISC_FEATURE
<222>  (179)..(289)
<223>  intracellular region

<400>  23

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210>  24
<211>  289
<212>  PRT
<213>  Macaca fascicularis

<400>  24

Met Lys Thr Leu Pro Ala Met Leu Gly Ser Gly Arg Leu Phe Trp Val 
1               5                   10                  15      


Val Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Tyr His Ser Ile 
        35                  40                  45              


Phe Ala Gly Asp Pro Phe Lys Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


His Arg Pro Gln Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Gly Arg His Thr Ser Trp Lys Gln Glu Lys Asn Leu Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Ser Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Leu Ser Ala Ile Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Ser Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Phe Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Thr 
            180                 185                 190         


Gly Arg Glu Ile Thr Leu Val Asp Val Pro Phe Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Glu Pro Asp Phe Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Ile 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Ile Ile Gly Leu Asn Ser Arg Gln Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210>  25

<400>  25
000

<210>  26

<400>  26
000

<210>  27

<400>  27
000

<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  31

Ser Tyr Gly Ile Ser 
1               5   


<210>  32
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  32

Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  33

Asn Tyr Gly Ser Ser Tyr Pro Phe Ala Tyr 
1               5                   10  


<210>  34
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  34

Ser Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  35
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  35

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  36

Gln Gln Trp Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  37
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  37

Asp Tyr Tyr Met Asn 
1               5   


<210>  38
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  38

Asp Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  39

Trp Arg Gln Leu Arg Ser Asp Tyr 
1               5               


<210>  40
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  40

Leu Ala Ser Gln Thr Ile Gly Thr Trp Leu Ala 
1               5                   10      


<210>  41
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  41

Ala Ala Thr Ser Leu Ala Asp 
1               5           


<210>  42
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  42

Gln Gln Leu Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  43
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  43

Ser Tyr Trp Met His 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  44

Met Ile His Pro Asn Asn Gly Ile Pro Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  45
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  45

Glu Gly Tyr Tyr Gly Ser Glu Gly Tyr Phe Asp Val 
1               5                   10          


<210>  46
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  46

Ser Ala Ser Ser Ser Ile Ser Tyr Ile His 
1               5                   10  


<210>  47
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  47

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  48

His Gln Arg Ser Thr Tyr Pro Tyr Thr 
1               5                   


<210>  49

<400>  49
000

<210>  50

<400>  50
000

<210>  51

<400>  51
000

<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55

<400>  55
000

<210>  56
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  56

Met Ile His Pro Asn Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  57
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  57

Lys Arg Gly Gly Leu Gly Asp Tyr 
1               5               


<210>  58
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  58

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  59
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  59

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  60

Gln His Ser Arg Glu Leu Pro Tyr Thr 
1               5                   


<210>  61
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  61

Ser Ser Trp Met Asn 
1               5   


<210>  62
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  62

Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  63

Arg Gly Tyr Gly Tyr Leu Ala Tyr 
1               5               


<210>  64
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  64

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  65
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  65

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  66

Gln Gln His Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  67

<400>  67
000

<210>  68

<400>  68
000

<210>  69
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  69

Gly Tyr Gly Ser Ser Tyr Gly Phe Ala Tyr 
1               5                   10  


<210>  70

<400>  70
000

<210>  71

<400>  71
000

<210>  72
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  72

Gln Gln Trp Ser Gly Tyr Pro Trp Thr 
1               5                   


<210>  73
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  73

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  74
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  74

Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  75
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  75

Ile Tyr Gly Asn Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  76
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  76

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  77

<400>  77
000

<210>  78
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  78

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  79
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  79

Asp Tyr Tyr Met Ile 
1               5   


<210>  80
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  80

Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  81
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  81

Gly Gly Leu Arg Pro Leu Tyr Phe Asp Tyr 
1               5                   10  


<210>  82
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  82

Lys Ala Ser Glu Asn Val Asp Thr Tyr Val Ser 
1               5                   10      


<210>  83
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  83

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  84
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  84

Gly Gln Ser Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  85
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  85

Asn Thr Tyr Met His 
1               5   


<210>  86
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  86

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  87

Thr Tyr Tyr Gly Ser Ser Gln His Tyr Phe Asp Tyr 
1               5                   10          


<210>  88
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  88

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  89
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  89

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  90
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  90

Trp Gln Asp Thr His Phe Pro Gln Thr 
1               5                   


<210>  91

<400>  91
000

<210>  92
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  92

Arg Ile Tyr Pro Gly Asp Gly Asp Ala Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  93

Glu Gly His Tyr Tyr Gly Ser Gly Tyr Arg Trp Tyr Leu Asp Val 
1               5                   10                  15  


<210>  94
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  94

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  95
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  95

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  96
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  96

Gln His Phe Arg Gly Ala Pro Phe Thr 
1               5                   


<210>  97
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  97

Asp Tyr Glu Ile His 
1               5   


<210>  98
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  98

Pro Ile Asp Pro Asp Thr Gly Asn Thr Ala Tyr Asn Gln Asn Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  99

Gly Gly Tyr Asp Ser Asp Trp Gly Phe Ala Tyr 
1               5                   10      


<210>  100
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  100

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Phe Leu Phe 
1               5                   10                  15      


<210>  101
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  101

Arg Met Ser Asp Leu Ala Ser 
1               5           


<210>  102
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  102

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  103
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  103

Asp Tyr Tyr Leu Asn 
1               5   


<210>  104
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  104

Leu Ile Asp Pro Tyr Asn Gly Gly Ser Ser Cys Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  105

Gly Asn Ala Met Asp Tyr 
1               5       


<210>  106

<400>  106
000

<210>  107
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  107

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  108
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  108

Gln Gln His Tyr Ile Ile Pro Tyr Met 
1               5                   


<210>  109
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  109

Asn Thr Tyr Met Tyr 
1               5   


<210>  110
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  110

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  111
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  111

Leu Tyr Tyr Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  112

<400>  112
000

<210>  113

<400>  113
000

<210>  114
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  114

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  117

Thr Tyr Tyr Gly Ser Ser Gln Tyr Tyr Phe Asp Tyr 
1               5                   10          


<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  121

Asp Tyr Tyr Ile Asn 
1               5   


<210>  122
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  122

Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  123

Gly Tyr Gly Asn Ser Asp Tyr 
1               5           


<210>  124
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  124

Arg Ala Ser Gln Ser Ile Gly Thr Arg Ile His 
1               5                   10      


<210>  125
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  125

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  126
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  126

Gln Gln Ser Asn Ser Trp Pro Tyr Thr 
1               5                   


<210>  127
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  127

Ser Tyr Ala Ile Arg 
1               5   


<210>  128
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  128

Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  129

Ser Gly Gly Ala Ser Tyr Thr Met Asp Tyr 
1               5                   10  


<210>  130

<400>  130
000

<210>  131

<400>  131
000

<210>  132

<400>  132
000

<210>  133
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  133

Ser Tyr Gly Leu Ile 
1               5   


<210>  134
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  134

Glu Ile Tyr Pro Arg Ser Gly Ser Thr Tyr Tyr Asn Glu Trp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  135

Arg Arg Gly Thr Gly Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  136
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  136

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  137
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  137

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  138
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  138

Gln Gln Tyr Ile Glu Leu Pro Phe Thr 
1               5                   


<210>  139
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  139

Asp Tyr Tyr Met His 
1               5   


<210>  140
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  140

Tyr Ile Tyr Pro Asn Asn Gly Gly Asn Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  141

Gly Asp Tyr Tyr Gly Ser Leu Arg Leu Thr Phe Ala Tyr 
1               5                   10              


<210>  142
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  142

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  143
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  143

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  144
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  144

Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  145
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  145

Thr Tyr Gly Val Ser 
1               5   


<210>  146
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  146

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  147
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  147

Val Thr Thr Ile Leu His Trp Tyr Phe Asp Val 
1               5                   10      


<210>  148
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  148

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  149
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  149

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  150
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  150

Leu Gln Tyr Ala Ser Tyr Pro Phe Thr 
1               5                   


<210>  151

<400>  151
000

<210>  152

<400>  152
000

<210>  153

<400>  153
000

<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  159

Arg Arg Gly Ala Gly Asp Gly Phe Asp Tyr 
1               5                   10  


<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  162

Gln Gln Tyr Ser Lys Leu Pro Phe Thr 
1               5                   


<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  169

Asp His Thr Ile His 
1               5   


<210>  170
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  170

Tyr Ile Tyr Pro Arg Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  171
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  171

Ser Asn Trp Asn Phe Asp Tyr 
1               5           


<210>  172
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  172

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  173
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  173

Trp Ala Ser Thr Arg Arg Thr 
1               5           


<210>  174
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  174

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  180

Gln Gln His Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  181

<400>  181
000

<210>  182
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  182

Glu Ile Tyr Pro Arg Ser Gly Thr Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  183
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  183

Arg Ile Ser Ser Gly Ser Gly Val Asp Tyr 
1               5                   10  


<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  186

Gln Gln Tyr Ser Glu Leu Pro Trp Thr 
1               5                   


<210>  187
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  187

Ser Gly Tyr Asp Trp His 
1               5       


<210>  188
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  188

Tyr Ile Ser Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  189
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  189

Gly Thr Pro Val Val Ala Glu Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  190
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  190

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  191
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  191

Ala Thr Asn Asn Arg Ala Pro 
1               5           


<210>  192
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  192

Ala Leu Trp Tyr Ser Asn His Leu Val 
1               5                   


<210>  193
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  193

Thr Tyr Gly Val His 
1               5   


<210>  194
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  194

Val Met Trp Pro Gly Gly Arg Thr Ser Tyr Asn Pro Ala Pro Met Ser 
1               5                   10                  15      


<210>  195
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  195

Gly Asp Tyr Glu Tyr Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  196
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  196

Arg Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  197
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  197

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  198

<400>  198
000

<210>  199
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  199

Ser Ala Tyr Trp Asn 
1               5   


<210>  200
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  200

Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Phe Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  201
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  201

Ser His Tyr Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  202
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  202

Arg Ala Ser Glu Thr Ile Asp Ser Tyr Gly Asp Ser Leu Met His 
1               5                   10                  15  


<210>  203
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  203

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  204

<400>  204
000

<210>  205
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  205

Ser Tyr Gly Met Ser 
1               5   


<210>  206
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  206

Ser Ile Arg Ser Asp Gly Asn Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  207
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  207

Gly Gly Tyr Tyr Gly Ser Ser Pro Tyr Tyr 
1               5                   10  


<210>  208

<400>  208
000

<210>  209
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  209

Trp Ala Ser Thr Arg Asp Ser 
1               5           


<210>  210
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  210

Gln Gln Tyr Tyr Asn Tyr Leu Thr 
1               5               


<210>  211
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  211

Ser Gly Tyr Ser Trp His 
1               5       


<210>  212
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  212

Tyr Ile His Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  213
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  213

Gly Pro His Arg Tyr Asp Gly Val Trp Phe Ala Tyr 
1               5                   10          


<210>  214
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  214

Ser Ala Ser Ser Ser Ile Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  215

<400>  215
000

<210>  216
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  216

Gln Gln Gly Thr Asn Ile Pro Leu Thr 
1               5                   


<210>  217

<400>  217
000

<210>  218

<400>  218
000

<210>  219

<400>  219
000

<210>  220

<400>  220
000

<210>  221

<400>  221
000

<210>  222

<400>  222
000

<210>  223

<400>  223
000

<210>  224

<400>  224
000

<210>  225

<400>  225
000

<210>  226

<400>  226
000

<210>  227

<400>  227
000

<210>  228

<400>  228
000

<210>  229

<400>  229
000

<210>  230

<400>  230
000

<210>  231

<400>  231
000

<210>  232

<400>  232
000

<210>  233

<400>  233
000

<210>  234

<400>  234
000

<210>  235

<400>  235
000

<210>  236

<400>  236
000

<210>  237

<400>  237
000

<210>  238

<400>  238
000

<210>  239

<400>  239
000

<210>  240

<400>  240
000

<210>  241

<400>  241
000

<210>  242

<400>  242
000

<210>  243

<400>  243
000

<210>  244

<400>  244
000

<210>  245

<400>  245
000

<210>  246

<400>  246
000

<210>  247

<400>  247
000

<210>  248

<400>  248
000

<210>  249

<400>  249
000

<210>  250

<400>  250
000

<210>  251

<400>  251
000

<210>  252

<400>  252
000

<210>  253

<400>  253
000

<210>  254

<400>  254
000

<210>  255

<400>  255
000

<210>  256

<400>  256
000

<210>  257

<400>  257
000

<210>  258

<400>  258
000

<210>  259

<400>  259
000

<210>  260

<400>  260
000

<210>  261

<400>  261
000

<210>  262

<400>  262
000

<210>  263

<400>  263
000

<210>  264

<400>  264
000

<210>  265

<400>  265
000

<210>  266

<400>  266
000

<210>  267

<400>  267
000

<210>  268

<400>  268
000

<210>  269

<400>  269
000

<210>  270

<400>  270
000

<210>  271

<400>  271
000

<210>  272

<400>  272
000

<210>  273

<400>  273
000

<210>  274

<400>  274
000

<210>  275

<400>  275
000

<210>  276

<400>  276
000

<210>  277

<400>  277
000

<210>  278

<400>  278
000

<210>  279

<400>  279
000

<210>  280

<400>  280
000

<210>  281

<400>  281
000

<210>  282

<400>  282
000

<210>  283

<400>  283
000

<210>  284

<400>  284
000

<210>  285

<400>  285
000

<210>  286

<400>  286
000

<210>  287

<400>  287
000

<210>  288

<400>  288
000

<210>  289

<400>  289
000

<210>  290

<400>  290
000

<210>  291

<400>  291
000

<210>  292

<400>  292
000

<210>  293

<400>  293
000

<210>  294

<400>  294
000

<210>  295

<400>  295
000

<210>  296

<400>  296
000

<210>  297

<400>  297
000

<210>  298

<400>  298
000

<210>  299

<400>  299
000

<210>  300

<400>  300
000

<210>  301
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  301

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Tyr Gly Ser Ser Tyr Pro Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  302
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  302

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Arg Gln Leu Arg Ser Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  303
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  303

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Arg Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asn Asn Gly Ile Pro Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Tyr Gly Ser Glu Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  304

<400>  304
000

<210>  305
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  305

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asn Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Arg Gly Gly Leu Gly Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  306
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  306

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Gly Tyr Leu Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  307
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  307

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ser Ser Tyr Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  308
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  308

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Tyr Gly Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  309
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  309

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ile Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gly Leu Pro Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Arg Pro Leu Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  310
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  310

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Val Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Thr Tyr Tyr Gly Ser Ser Gln His Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  311
<211>  124
<212>  PRT
<213>  Mus musculus

<400>  311

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Lys Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asp Ala Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Gly Glu Gly His Tyr Tyr Gly Ser Gly Tyr Arg Trp Tyr Leu Asp 
            100                 105                 110         


Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  312
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  312

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile His Trp Val Lys Gln Thr Leu Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Pro Ile Asp Pro Asp Thr Gly Asn Thr Ala Tyr Asn Gln Asn Leu 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Tyr Asp Ser Asp Trp Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  313
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  313

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asp Pro Tyr Asn Gly Gly Ser Ser Cys Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  314
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  314

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Leu Tyr Tyr Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  315
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  315

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Thr Tyr Tyr Gly Ser Ser Gln Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  316
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  316

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  317
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  317

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Ile Arg Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Ala Ser Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  318
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  318

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Leu Ile Trp Leu Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Ser Thr Tyr Tyr Asn Glu Trp Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Thr Gly Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ile Leu Thr Val Ser Ser 
        115                 


<210>  319
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  319

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Asn Asn Gly Gly Asn Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Gly Asp Tyr Tyr Gly Ser Leu Arg Leu Thr Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  320
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  320

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Lys Gln Ala Pro Gly Lys Val Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Pro Val Thr Thr Ile Leu His Trp Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  321
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  321

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Tyr Gly Ser Ser Tyr Pro Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  322
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  322

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Arg Gly Ala Gly Asp Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  323

<400>  323
000

<210>  324
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  324

Gln Asp Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Thr Ile His Trp Met Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Arg Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Ser Asn Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  325

<400>  325
000

<210>  326
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  326

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Thr Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ile Ser Ser Gly Ser Gly Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  327
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  327

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Met Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Asp Trp His Trp Ile Arg His Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr His Asp Thr Ser Lys Asn His Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Pro Val Val Ala Glu Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  328

<400>  328
000

<210>  329

<400>  329
000

<210>  330
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  330

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ile Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Arg Ser Asp Gly Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Gly Tyr Tyr Gly Ser Ser Pro Tyr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  331
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  331

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Pro His Arg Tyr Asp Gly Val Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  332

<400>  332
000

<210>  333

<400>  333
000

<210>  334

<400>  334
000

<210>  335

<400>  335
000

<210>  336

<400>  336
000

<210>  337

<400>  337
000

<210>  338

<400>  338
000

<210>  339

<400>  339
000

<210>  340

<400>  340
000

<210>  341

<400>  341
000

<210>  342

<400>  342
000

<210>  343

<400>  343
000

<210>  344

<400>  344
000

<210>  345

<400>  345
000

<210>  346

<400>  346
000

<210>  347

<400>  347
000

<210>  348

<400>  348
000

<210>  349

<400>  349
000

<210>  350

<400>  350
000

<210>  351
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  351

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ala Ala Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Pro Leu 
        35                  40                  45              


Ile His Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  352
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  352

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  353
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  353

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  354

<400>  354
000

<210>  355
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  355

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  356
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  356

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  357
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  357

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ala Ala Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Pro Leu 
        35                  40                  45              


Ile His Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  358
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  358

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  359
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  359

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Asp Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Ile 
            100                 105         


<210>  360
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  360

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Asp 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  361
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  361

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Arg Gly Ala Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  362
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  362

Asp Ile Val Met Thr Gln Ala Thr Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu Phe Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asp Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  363
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  363

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Glu Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ile Leu Asn Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ile Ile Pro Tyr 
                85                  90                  95      


Met Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  364
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  364

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  365

<400>  365
000

<210>  366
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  366

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Arg 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  367
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  367

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ala Ala Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Pro Leu 
        35                  40                  45              


Ile His Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  368
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  368

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Glu Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  369
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  369

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  370
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  370

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Arg Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  371

<400>  371
000

<210>  372
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  372

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  373

<400>  373
000

<210>  374
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  374

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg Arg Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  375
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  375

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  376
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  376

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  377
<211>  110
<212>  PRT
<213>  Mus musculus

<400>  377

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Ser Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Ala Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  378
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  engineered humanised 6.2 VL

<400>  378

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  379

<400>  379
000

<210>  380
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  380

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Pro Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Ile Ser Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asn Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  381
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  381

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Thr Asn Ile Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  382
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanised 3E8 VH

<400>  382

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Ile Arg Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Ala Ser Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  383
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanised 3E8 VL

<400>  383

Glu Asn Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Pro Leu 
        35                  40                  45              


Ile His Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  384
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanised 6.2 VH

<400>  384

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Arg Ser Asp Gly Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Gly Tyr Tyr Gly Ser Ser Pro Tyr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  385
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanised 6.2 VL

<400>  385

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  386
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  386

Glu Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  387
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  387

Ser Ile Arg Ser Glu Gly Gln Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  388
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  388

Glu Ile Tyr Pro Arg Ser Gly Gln Thr Tyr Tyr Ala Gln Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  389
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  engineered humanised 3E8 VH

<400>  389

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Ile Arg Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Gly Gln Thr Tyr Tyr Ala Gln Ser Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Ala Ser Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  390
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  engineered humanised 6.2 VH 2nd

<400>  390

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Arg Ser Glu Gly Gln Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Gly Tyr Tyr Gly Ser Ser Pro Tyr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


