                         SEQUENCE LISTING

<110>  PHILOCHEM AG
 
<120>  NUCLEIC ACID ENCODED CHEMICAL LIBRARIES

<130>  007570112

<140>  PCT/EP2019/086831
<141>  2019-12-20

<150>  GB 1821109.4
<151>  2018-12-21

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amino-modified 48-mer oligonucleotide

<400>  1
ggagcttctg aattctgtgt gctgacgtaa cgagtcccat ggcgcagc                    48


<210>  2
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amino-modified d-spacer oligonucleotide (MW = 12058.74 Da)


<220>
<221>  misc_feature
<222>  (12)..(17)
<223>  'dddddd' is an abasic region

<400>  2
catgggactc gddddddcag cacacagaat tcagaagctc c                           41


<210>  3
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-aminomodified, 48-mer oligonucleotide (Elib2_Code1)

<400>  3
ggagcttctg aattctgtgt gctgactatc cgagtcccat ggcgcagc                    48


<210>  4
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  38-mer oligonucleotide (Elib4_Code2)

<400>  4
cctgcatcga atggatccgt gaattattcg cagctgcg                               38


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  21-mer oligonucleotide RNA adaptor (Elib4_aT)


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = rG

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n = 5-methyl uracil

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = rC

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n = rG

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n = rC

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n = rA

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n = rG

<400>  5
cgannnccat ggcnnnnctg c                                                 21


<210>  6
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-amino-modified, 45-mer oligonucleotide (Elib5_Code1)


<220>
<221>  misc_feature
<222>  (25)..(30)
<223>  n is a, c, g, or t

<400>  6
ggagcttctg aattctgtgt gctgnnnnnn cgagtcccat ggcgc                       45


<210>  7
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-phosphorylated, 29-mer oligonucleotide (Elib5_Code2)


<220>
<221>  misc_feature
<222>  (11)..(17)
<223>  n is a, c, g, or t

<400>  7
cggatcgacg nnnnnnngcg tcaggcagc                                         29


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  25-mer oligonucleotide DNA adaptor (Elib5_aH)

<400>  8
cgtcgatccg gcgccatggg actgg                                             25


<210>  9
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  65-mer oligonucleotide (Elib6_Code3


<220>
<221>  misc_feature
<222>  (45)..(51)
<223>  'ddddddd' is an abasic region

<400>  9
gctctgcacg gtcgcctgag atgtaggatc acgctgcctg acgcdddddd dcgtcgatcc       60

ggcgc                                                                   65


<210>  10
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14-mer oligonucleotide DNA adaptor (Elib6_aH_14mer)

<400>  10
tcccatggcg ccgg                                                         14


<210>  11
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34-mer oligonucleotide (YL_Code3, S)

<400>  11
gctctgcacg gtcgcctgag atgctgcctg acgc                                   34


<210>  12
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  65-mer oligonucleotide (Elib6_Code3#1-n)


<220>
<221>  misc_feature
<222>  (16)..(22)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (45)..(51)
<223>  'ddddddd' is an abasic region

<400>  12
gctctgcacg gtcgcnnnnn nngtaggatc acgctgcctg acgcdddddd dcgtcgatcc       60

ggcgc                                                                   65


<210>  13
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  51-mer oligonucleotide (Primer 1aXX,)


<220>
<221>  misc_feature
<222>  (22)..(27)
<223>  n is a, c, g, or t

<400>  13
tacacgacgc tcttccgatc tnnnnnngga gcttctgaat tctgtgtgct g                51


<210>  14
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  42-mer oligonucleotide (Primer 1b-a)

<400>  14
cagacgtgtg ctcttccgat ccgatatgct ctgcacggtc gc                          42


<210>  15
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA construct built by the PCR1 of the single-pharmacophore

<400>  15
ggagcttctg aattctgtgt gctgaaggtc cgagtcccat ggcgccggat cgacggtctc       60

acgcgtcagg cagc                                                         74


<210>  16
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the single-pharmacophore

<400>  16
cgcagtccgt cgtagagtcg ctggcacgtc tcg                                    33


<210>  17
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the single-pharmacophore

<400>  17
ggagcttctg aattctgtgt gctgaaggtc cgagtcccat ggcgccggat cgacggtctc       60

acgcgtcagg cagcatctca gcgaccgtgc agagc                                  95


<210>  18
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the single-pharmacophore

<400>  18
cctcgaagac ttaagacaca cgacttccag gctcagggta ccgcggccta gctgccagag       60

tgcgcagtcc gtcgtagagt cgctggcacg tctcg                                  95


<210>  19
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the single-pharmacophore

<400>  19
cgctggcacg tctcgtatag cctagccttc tcgtgtgcag ac                          42


<210>  20
<211>  149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the single-pharmacophore


<220>
<221>  misc_feature
<222>  (22)..(27)
<223>  n is a, c, g, or t

<400>  20
tacacgacgc tcttccgatc tnnnnnngga gcttctgaat tctgtgtgct gaaggtccga       60

gtcccatggc gccggatcga cggtctcacg cgtcaggcag catctcagcg accgtgcaga      120

gcatatcgga tcggaagagc acacgtctg                                        149


<210>  21
<211>  149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the single-pharmacophore


<220>
<221>  misc_feature
<222>  (123)..(128)
<223>  n is a, c, g, or t

<400>  21
cagacgtgtg ctcttccgat ccgatatgct ctgcacggtc gctgagatgc tgcctgacgc       60

gtgagaccgt cgatccggcg ccatgggact cggaccttca gcacacagaa ttcagaagct      120

ccnnnnnnag atcggaagag cgtcgtgta                                        149


<210>  22
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the dual-pharmacophores


<220>
<221>  misc_feature
<222>  (35)..(40)
<223>  'dddddd' is an abasic region

<220>
<221>  misc_feature
<222>  (56)..(62)
<223>  'ddddddd' is an abasic region

<400>  22
cctcgaagac ttaagacaca cgacdddddd gctcagggta ccgcggccta gctgcddddd       60

ddcgcagtcc gtcgcactag gatgttaggc tcgctggcac gtctcg                     106


<210>  23
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the dual-pharmacophores

<400>  23
ggagcttctg aattctgtgt gctgaaggtc cgagtcccat ggcgccggat cgacggtctc       60

acgcgtcagg cagcgtgatc ctacttaggc tgcgaccgtg cagagc                     106


<210>  24
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the dual-pharmacophores


<220>
<221>  misc_feature
<222>  (35)..(40)
<223>  'dddddd' is an abasic region

<220>
<221>  misc_feature
<222>  (56)..(62)
<223>  'ddddddd' is an abasic region

<400>  24
cctcgaagac ttaagacaca cgacdddddd gctcagggta ccgcggccta gctgcddddd       60

ddcgcagtcc gtcgcactag gatgaatccg acgctggcac gtctcg                     106


<210>  25
<211>  160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the dual-pharmacophores


<220>
<221>  misc_feature
<222>  (22)..(27)
<223>  n is a, c, g, or t

<400>  25
tacacgacgc tcttccgatc tnnnnnngga gcttctgaat tctgtgtgct gaaggtccga       60

gtcccatggc gccggatcga cggtctcacg cgtcaggcag cgtgatccta cttaggctgc      120

gaccgtgcag agcatatcgg atcggaagag cacacgtctg                            160


<210>  26
<211>  160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA constructs built by the PCR1 of the dual-pharmacophores


<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  'ddddddd' is an abasic region

<220>
<221>  misc_feature
<222>  (104)..(109)
<223>  'dddddd' is an abasic region

<220>
<221>  misc_feature
<222>  (134)..(139)
<223>  n is a, c, g, or t

<400>  26
cagacgtgtg ctcttccgat ccgatatgct ctgcacggtc gcagcctaag taggatcacg       60

ctgcctgacg cdddddddcg tcgatccggc gccatgggac tcgddddddc agcacacaga      120

attcagaagc tccnnnnnna gatcggaaga gcgtcgtgta                            160


