                         SEQUENCE LISTING

<110>  4TEEN4 Pharmaceuticals GmbH
 
<120>  Therapy Guidance and/or Therapy Monitoring for a treatment with 
       Angiotensin-Receptor-Agonist and/or a Precursor thereof

<130>  S75285WO

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Asp Thr Gln Tyr Ile Leu Pro Asn Asp Ile Gly Val Ser Ser 
1               5                   10                  15      


Leu Asp Cys Arg Glu Ala Phe Arg Leu Leu Ser Pro Thr Glu Arg Leu 
            20                  25                  30          


Tyr Ala Tyr His Leu Ser Arg Ala Ala Trp Tyr Gly Gly Leu Ala Val 
        35                  40                  45              


Leu Leu Gln Thr Ser Pro Glu Ala Pro Tyr Ile Tyr Ala Leu Leu Ser 
    50                  55                  60                  


Arg Leu Phe Arg Ala Gln Asp Pro Asp Gln Leu Arg Gln His Ala Leu 
65                  70                  75                  80  


Ala Glu Gly Leu Thr Glu Glu Glu Tyr Gln Ala Phe Leu Val Tyr Ala 
                85                  90                  95      


Ala Gly Val Tyr Ser Asn Met Gly Asn Tyr Lys Ser Phe Gly Asp Thr 
            100                 105                 110         


Lys Phe Val Pro Asn Leu Pro Lys Glu Lys Leu Glu Arg Val Ile Leu 
        115                 120                 125             


Gly Ser Glu Ala Ala Gln Gln His Pro Glu Glu Val Arg Gly Leu Trp 
    130                 135                 140                 


Gln Thr Cys Gly Glu Leu Met Phe Ser Leu Glu Pro Arg Leu Arg His 
145                 150                 155                 160 


Leu Gly Leu Gly Lys Glu Gly Ile Thr Thr Tyr Phe Ser Gly Asn Cys 
                165                 170                 175     


Thr Met Glu Asp Ala Lys Leu Ala Gln Asp Phe Leu Asp Ser Gln Asn 
            180                 185                 190         


Leu Ser Ala Tyr Asn Thr Arg Leu Phe Lys Glu Val Asp Gly Glu Gly 
        195                 200                 205             


Lys Pro Tyr Tyr Glu Val Arg Leu Ala Ser Val Leu Gly Ser Glu Pro 
    210                 215                 220                 


Ser Leu Asp Ser Glu Val Thr Ser Lys Leu Lys Ser Tyr Glu Phe Arg 
225                 230                 235                 240 


Gly Ser Pro Phe Gln Val Thr Arg Gly Asp Tyr Ala Pro Ile Leu Gln 
                245                 250                 255     


Lys Val Val Glu Gln Leu Glu Lys Ala Lys Ala Tyr Ala Ala Asn Ser 
            260                 265                 270         


His Gln Gly Gln Met Leu Ala Gln Tyr Ile Glu Ser Phe Thr Gln Gly 
        275                 280                 285             


Ser Ile Glu Ala His Lys Arg Gly Ser Arg Phe Trp Ile Gln Asp Lys 
    290                 295                 300                 


Gly Pro Ile Val Glu Ser Tyr Ile Gly Phe Ile Glu Ser Tyr Arg Asp 
305                 310                 315                 320 


Pro Phe Gly Ser Arg Gly Glu Phe Glu Gly Phe Val Ala Val Val Asn 
                325                 330                 335     


Lys Ala Met Ser Ala Lys Phe Glu Arg Leu Val Ala Ser Ala Glu Gln 
            340                 345                 350         


Leu Leu Lys Glu Leu Pro Trp Pro Pro Thr Phe Glu Lys Asp Lys Phe 
        355                 360                 365             


Leu Thr Pro Asp Phe Thr Ser Leu Asp Val Leu Thr Phe Ala Gly Ser 
    370                 375                 380                 


Gly Ile Pro Ala Gly Ile Asn Ile Pro Asn Tyr Asp Asp Leu Arg Gln 
385                 390                 395                 400 


Thr Glu Gly Phe Lys Asn Val Ser Leu Gly Asn Val Leu Ala Val Ala 
                405                 410                 415     


Tyr Ala Thr Gln Arg Glu Lys Leu Thr Phe Leu Glu Glu Asp Asp Lys 
            420                 425                 430         


Asp Leu Tyr Ile Leu Trp Lys Gly Pro Ser Phe Asp Val Gln Val Gly 
        435                 440                 445             


Leu His Glu Leu Leu Gly His Gly Ser Gly Lys Leu Phe Val Gln Asp 
    450                 455                 460                 


Glu Lys Gly Ala Phe Asn Phe Asp Gln Glu Thr Val Ile Asn Pro Glu 
465                 470                 475                 480 


Thr Gly Glu Gln Ile Gln Ser Trp Tyr Arg Ser Gly Glu Thr Trp Asp 
                485                 490                 495     


Ser Lys Phe Ser Thr Ile Ala Ser Ser Tyr Glu Glu Cys Arg Ala Glu 
            500                 505                 510         


Ser Val Gly Leu Tyr Leu Cys Leu His Pro Gln Val Leu Glu Ile Phe 
        515                 520                 525             


Gly Phe Glu Gly Ala Asp Ala Glu Asp Val Ile Tyr Val Asn Trp Leu 
    530                 535                 540                 


Asn Met Val Arg Ala Gly Leu Leu Ala Leu Glu Phe Tyr Thr Pro Glu 
545                 550                 555                 560 


Ala Phe Asn Trp Arg Gln Ala His Met Gln Ala Arg Phe Val Ile Leu 
                565                 570                 575     


Arg Val Leu Leu Glu Ala Gly Glu Gly Leu Val Thr Ile Thr Pro Thr 
            580                 585                 590         


Thr Gly Ser Asp Gly Arg Pro Asp Ala Arg Val Arg Leu Asp Arg Ser 
        595                 600                 605             


Lys Ile Arg Ser Val Gly Lys Pro Ala Leu Glu Arg Phe Leu Arg Arg 
    610                 615                 620                 


Leu Gln Val Leu Lys Ser Thr Gly Asp Val Ala Gly Gly Arg Ala Leu 
625                 630                 635                 640 


Tyr Glu Gly Tyr Ala Thr Val Thr Asp Ala Pro Pro Glu Cys Phe Leu 
                645                 650                 655     


Thr Leu Arg Asp Thr Val Leu Leu Arg Lys Glu Ser Arg Lys Leu Ile 
            660                 665                 670         


Val Gln Pro Asn Thr Arg Leu Glu Gly Ser Asp Val Gln Leu Leu Glu 
        675                 680                 685             


Tyr Glu Ala Ser Ala Ala Gly Leu Ile Arg Ser Phe Ser Glu Arg Phe 
    690                 695                 700                 


Pro Glu Asp Gly Pro Glu Leu Glu Glu Ile Leu Thr Gln Leu Ala Thr 
705                 710                 715                 720 


Ala Asp Ala Arg Phe Trp Lys Gly Pro Ser Glu Ala Pro Ser Gly Gln 
                725                 730                 735     


Ala 
    


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Glu Thr Val Ile Asn Pro Glu Thr Gly Glu Gln Ile Gln Ser Trp 
1               5                   10                  15      


Tyr Arg Ser Gly Glu 
            20      


<210>  3
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Asn Pro Glu Thr Gly 
1               5       


<210>  4
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Ser Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Val Thr Ala Asp Thr Gly Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asn Tyr Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  5
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  5

Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Val His Ser 
            20                  25                  30          


Ile Gly Ser Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  6
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Phe Ser Leu Ser Thr Ser Gly Met Ser 
1               5                   10  


<210>  7
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  7

Ile Trp Trp Asn Asp Asn Lys 
1               5           


<210>  8
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  8

Ala Arg Asn Tyr Ser Tyr Asp Tyr 
1               5               


<210>  9
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  9

Arg Ser Leu Val His Ser Ile Gly Ser Thr Tyr 
1               5                   10      


<210>  10
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  10

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  11
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Ile Thr Leu Lys Glu Ser Gly 
            20                  25                  30          


Pro Thr Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe 
        35                  40                  45              


Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Ser Val Gly Trp Ile Arg 
    50                  55                  60                  


Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala His Ile Trp Trp Asn 
65                  70                  75                  80  


Asp Asn Lys Ser Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Thr 
                85                  90                  95      


Arg Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp 
            100                 105                 110         


Pro Val Asp Thr Gly Thr Tyr Tyr Cys Ala Arg Asn Tyr Ser Tyr Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  12
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Arg Ser 
        35                  40                  45              


Leu Val His Ser Ile Gly Ser Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Arg Val Tyr Ile His Pro Phe 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin II variant

<400>  14

Asp Arg Val Tyr Val His Pro Phe 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin II variant

<400>  15

Asn Arg Val Phe Ile His Pro Phe 
1               5               


<210>  16
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  16

Val Tyr Ile His Pro Phe 
1               5       


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Asn Arg Val Tyr Tyr Val His Pro Phe 
1               5                   


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin II analogue

<400>  18

Asn Arg Val Tyr Ile His Pro Ile 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin II analogue

<400>  19

Asn Arg Val Tyr Ile His Pro Ala 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin II analogue

<400>  20

Asn Arg Val Tyr Ile His Pro Phe 
1               5               


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Arg Val Tyr Ile His Pro Phe 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin III analogue

<400>  22

Arg Val Tyr Val His Pro Phe 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin III analogue

<400>  23

Arg Val Phe Ile His Pro Phe 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin III analogue

<400>  24

Arg Val Tyr Ile His Pro Ala 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin III analogue

<400>  25

Arg Val Tyr Ile His Pro Phe 
1               5           


<210>  26
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  26

Val Tyr Ile His Pro Phe 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin IV analogue

<400>  27

Val Tyr Val His Pro Phe 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin IV analogue

<400>  28

Val Phe Ile His Pro Phe 
1               5       


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensing IV analogue

<400>  29

Val Tyr Ile His Pro Ala 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin IV analogue

<400>  30

Val Tyr Ile His Pro Phe 
1               5       


