﻿               SEQUENCE LISTING

<110> ViGeneron GmbH

<120> An optimized acceptor splice site module for biological and biotechnological applications

<130> 116313P1274PC

<150> EP18214415.4
<151> 2018-12-20

<160> 40

<170> BiSSAP 1.3.6

<210> 1
<211> 13
<212> DNA
<213> Unknown


<220> 
<223> pyrimidine tract

<400> 1
tcttttgtca tct                                                       13


<210> 2
<211> 10
<212> DNA
<213> Unknown


<220> 
<223> intronic splice enhancer

<400> 2
tggggggagg                                                           10


<210> 3
<211> 26
<212> DNA
<213> Unknown


<220> 
<223> ASS region

<400> 3
caacgagtct tttgtcatct acaggt                                         26


<210> 4
<211> 26
<212> DNA
<213> Unknown


<220> 
<223> ASS region

<400> 4
caacgagttt tttgtcatct acaggt                                         26


<210> 5
<211> 50
<212> DNA
<213> Unknown


<220> 
<223> ASS region

<400> 5
ctacacgctc aagccggagg tcaacaacga gtcttttgtc atctacaggt                50


<210> 6
<211> 38
<212> DNA
<213> Unknown


<220> 
<223> ASS region

<400> 6
gccggaggtc aacaacgagt cttttgtcat ctacaggt                             38


<210> 7
<211> 20
<212> DNA
<213> Unknown


<220> 
<223> ASS region

<400> 7
gtcttttgtc atctacaggt                                                20


<210> 8
<211> 39
<212> DNA
<213> Unknown


<220> 
<223> ASS region

<400> 8
gtcttttgtc atctacaggt gttcgtggtt cgtggtcca                            39


<210> 9
<211> 166
<212> DNA
<213> Unknown


<220> 
<223> exon 3 of rhodopsin gene (containing the c.620T>G mutation

<400> 9
gtacatcccc gagggcctgc agtgctcgtg tggaatcgac tactacacgc tcaagccgga     60

ggtcaacaac gagtcttttg tcatctacag gttcgtggtc cacttcacca tccccatgat    120

tatcatcttt ttctgctatg ggcagctcgt cttcaccgtc aaggag                   166


<210> 10
<211> 1213
<212> DNA
<213> Unknown


<220> 
<223> mutated rhodopsin

<400> 10
ccagctggag ccctgagtgg ctgagctcag gccttcgcag cattcttggg tgggagcagc      60

cacgggtcag ccacaagggc cacagccatg aatggcacag aaggccctaa cttctacgtg     120

cccttctcca atgcgacggg tgtggtacgc agccccttcg agtacccaca gtactacctg     180

gctgagccat ggcagttctc catgctggcc gcctacatgt ttctgctgat cgtgctgggc     240

ttccccatca acttcctcac gctctacgtc accgtccagc acaagaagct gcgcacgcct     300

ctcaactaca tcctgctcaa cctagccgtg gctgacctct tcatggtcct aggtggcttc     360

accagcaccc tctacacctc tctgcatgga tacttcgtct tcgggcccac aggatgcaat     420

ttggagggct tctttgccac cctgggcggt gaaattgccc tgtggtcctt ggtggtcctg     480

gccatcgagc ggtacgtggt ggtgtgtaag cccatgagca acttccgctt cggggagaac     540

catgccatca tgggcgttgc cttcacctgg gtcatggcgc tggcctgcgc cgcaccccca     600

ctcgccggct ggtccaggta catccccgag ggcctgcagt gctcgtgtgg aatcgactac     660

tacacgctca agccggaggt caacaacgag tcttttgtca tctacaggtt cgtggtccac     720

ttcaccatcc ccatgattat catctttttc tgctatgggc agctcgtctt caccgtcaag     780

gaggccgctg cccagcagca ggagtcagcc accacacaga aggcagagaa ggaggtcacc     840

cgcatggtca tcatcatggt catcgctttc ctgatctgct gggtgcccta cgccagcgtg     900

gcattctaca tcttcaccca ccagggctcc aacttcggtc ccatcttcat gaccatccca     960

gcgttctttg ccaagagcgc cgccatctac aaccctgtca tctatatcat gatgaacaag    1020

cagttccgga actgcatgct caccaccatc tgctgcggca agaacccact gggtgacgat    1080

gaggcctctg ctaccgtgtc caagacggag acgagccagg tggccccggc ctaagacctg    1140

cctaggactc tgtggccgac tataggcgtc tcccatcccc tacaccttcc cccagccaca    1200

gccatcccac cag                                                       1213


<210> 11
<211> 13
<212> DNA
<213> Unknown


<220> 
<223> pyrimidine tract

<400> 11
ttttttgtca ttt                                                       13


<210> 12
<211> 14
<212> DNA
<213> Unknown


<220> 
<223> pyrimidine tract

<400> 12
tcttttgtca tcta                                                      14


<210> 13
<211> 21
<212> DNA
<213> Unknown


<220> 
<223> pyrimidine tract

<400> 13
caacgagtct tttgtcatct a                                              21


<210> 14
<211> 130
<212> DNA
<213> Unknown


<220> 
<223> inverted repeat

<400> 14
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt     60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact    120

aggggttcct                                                           130


<210> 15
<211> 130
<212> DNA
<213> Unknown


<220> 
<223> inverted repeat

<400> 15
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc    120

gagcgcgcag                                                           130


<210> 16
<211> 82
<212> DNA
<213> Unknown


<220> 
<223> poly A sequence

<400> 16
gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     60

tataagctgc aataaacaag tt                                              82


<210> 17
<211> 100
<212> DNA
<213> Unknown


<220> 
<223> first binding domain

<400> 17
agtgcatcaa ggcgatcaca tcagtgaaaa aaagccagac aggcggttaa accaacgcag     60

attaaacagc aggatgcaaa aattcgcagg tggtcagatg                          100


<210> 18
<211> 100
<212> DNA
<213> Unknown


<220> 
<223> second binding domain

<400> 18
catctgacca cctgcgaatt tttgcatcct gctgtttaat ctgcgttggt ttaaccgcct     60

gtctggcttt ttttcactga tgtgatcgcc ttgatgcact                          100


<210> 19
<211> 4455
<212> DNA
<213> Unknown


<220> 
<223> Sequence shown in Fig 5

<400> 19
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagcga cattgattat      240

tgactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt      300

tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc      360

cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac      420

gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata      480

tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc      540

agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta      600

ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac      660

ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc      720

aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc      780

gtgtacggtg ggaggtctat ataagcagag ctggtaccac cggtgccacc atgggcttcg      840

tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg caaaagattc      900

gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc tggttaagga      960

atgccaaccc actctacagc catcatgaat gccatttccc caacaaggcg atgccctcag     1020

caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc tgttttcaaa     1080

gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc atcttggcaa     1140

gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag caccttggcc     1200

gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg actcacccgg     1260

agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa gaaacactga     1320

cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt ctgatcaact     1380

ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg aaggacatcg     1440

cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc ggggcaaaga     1500

cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata gaagacactc     1560

tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct tcccacactc ctagacagcc     1620

gttctcaagg tatcaatctg agatcttggg gaggaatatt atctgatatg tcaccaagaa     1680

ttcaagagtt tatccatcgg ccgagtatgc aggacttgct gtgggtgacc aggcccctca     1740

tgcagaatgg tggtccagag acctttacaa agctgatggg catcctgtct gacctcctgt     1800

gtggctaccc cgagggaggt ggctctcggg tgctctcctt caactggtat gaagacaata     1860

actataaggc ctttctgggg attgactcca caaggaagga tcctatctat tcttatgaca     1920

gaagaacaac atccttttgt aatgcattga tccagagcct ggagtcaaat cctttaacca     1980

aaatcgcttg gagggcggca aagcctttgc tgatgggaaa aatcctgtac actcctgatt     2040

cacctgcagc acgaaggata ctgaagaatg ccaactcaac ttttgaagaa ctggaacacg     2100

ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca gatctggtac ttctttgaca     2160

acagcacaca gatgaacatg atcagagata ccctggggaa cccaacagta aaagactttt     2220

tgaataggca gcttggtgaa gaaggtatta ctgctgaagc catcctaaac ttcctctaca     2280

agggccctcg ggaaagccag gctgacgaca tggccaactt cgactggagg gacatattta     2340

acatcactga tcgcaccctc cgcctggtca atcaatacct ggagtgcttg gtcctggata     2400

agtttgaaag ctacaatgat gaaactcagc tcacccaacg tgccctctct ctactggagg     2460

aaaacatgtt ctgggccgga gtggtattcc ctgacatgta tccctggacc agctctctac     2520

caccccacgt gaagtataag atccgaatgg acatagacgt ggtggagaaa accaataaga     2580

ttaaagacag gtattgggat tctggtccca gagctgatcc cgtggaagat ttccggtaca     2640

tctggggcgg gtttgcctat ctgcaggaca tggttgaaca ggggatcaca aggagccagg     2700

tgcaggcgga ggctccagtt ggaatctacc tccagcagat gccctacccc tgcttcgtgg     2760

acgattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg ctggcatgga     2820

tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg cgactgaagg     2880

agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg ttcctggaca     2940

gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg catggaagaa     3000

tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc tccactgcca     3060

ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg gcagcagcct     3120

gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc gcctggcagg     3180

accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg gcatttggat     3240

ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag tggagcaaca     3300

tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg cagatgatgc     3360

tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg tttccaggag     3420

actatggaac cccacttcct tggtactttc ttctacaaga gtcgtattgg cttggcggtg     3480

aagggtgttc aaccagagaa gaaagagccc tggaaaagac cgagccccta acagaggaaa     3540

cggaggatcc agagcaccca gaaggaatac acgactcctt ctttgaacgt gagcatccag     3600

ggtgggttcc tggggtatgc gtgaagaatc tggtaaagat ttttgagccc tgtggccggc     3660

cagctgtgga ccgtctgaac atcaccttct acgagaacca gatcaccgca ttcctgggcc     3720

acaatggagc tgggaaaacc accaccttgt ccatcctgac gggtctgttg ccaccaacct     3780

ctgggactgt gctcgttggg ggaagggaca ttgaaaccag cctggatgca gtccggcaga     3840

gccttggcat gtgtccacag cacaacatcc tgttccacca cctcacggtg gctgagcaca     3900

tgctgttcta tgcccagctg aaaggaaagt cccaggagga ggcccagctg gagatggaag     3960

ccatgttgga ggacacaggc ctccaccaca agcggaatga agaggctcag gacctatcag     4020

gtggcatgca gagaaagctg tcggttgcca ttgcctttgt gggagatgcc aaggtaaggg     4080

cactgagcag aagggaagaa gctccggggg ctctttgtag ggtaagctta gtgcatcaag     4140

gcgatcacat cagtgaaaaa aagccagaca ggcggttaaa ccaacgcaga ttaaacagca     4200

ggatgcaaaa attcgcaggt ggtcagatga agcttattct cgagttaagg gcgaattccc     4260

gattaggatc ttcctagagc atggctacgt agataagtag catggcgggt taatcattaa     4320

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4380

tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag     4440

cgagcgagcg cgcag                                                      4455


<210> 20
<211> 4855
<212> DNA
<213> Unknown


<220> 
<223> Sequence shown in Figure 6

<400> 20
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagcga cattgattat      240

tgactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt      300

tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc      360

cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac      420

gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata      480

tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc      540

agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta      600

ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac      660

ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc      720

aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc      780

gtgtacggtg ggaggtctat ataagcagag ctggtaccac cggtagaaag cttcatctga      840

ccacctgcga atttttgcat cctgctgttt aatctgcgtt ggtttaaccg cctgtctggc      900

tttttttcac tgatgtgatc gccttgatgc actaagcttc aacgagtctt ttgtcatcta      960

caggtggtga ttctggacga acccacctct ggggtggacc cttactcgag acgctcaatc     1020

tgggatctgc tcctgaagta tcgctcaggc agaaccatca tcatgtccac tcaccacatg     1080

gacgaggccg acctccttgg ggaccgcatt gccatcattg cccagggaag gctctactgc     1140

tcaggcaccc cactcttcct gaagaactgc tttggcacag gcttgtactt aaccttggtg     1200

cgcaagatga aaaacatcca gagccaaagg aaaggcagtg aggggacctg cagctgctcg     1260

tctaagggtt tctccaccac gtgtccagcc cacgtcgatg acctaactcc agaacaagtc     1320

ctggatgggg atgtaaatga gctgatggat gtagttctcc accatgttcc agaggcaaag     1380

ctggtggagt gcattggtca agaacttatc ttccttcttc caaataagaa cttcaagcac     1440

agagcatatg ccagcctttt cagagagctg gaggagacgc tggctgacct tggtctcagc     1500

agttttggaa tttctgacac tcccctggaa gagatttttc tgaaggtcac ggaggattct     1560

gattcaggac ctctgtttgc gggtggcgct cagcagaaaa gagaaaacgt caacccccga     1620

cacccctgct tgggtcccag agagaaggct ggacagacac cccaggactc caatgtctgc     1680

tccccagggg cgccggctgc tcacccagag ggccagcctc ccccagagcc agagtgccca     1740

ggcccgcagc tcaacacggg gacacagctg gtcctccagc atgtgcaggc gctgctggtc     1800

aagagattcc aacacaccat ccgcagccac aaggacttcc tggcgcagat cgtgctcccg     1860

gctacctttg tgtttttggc tctgatgctt tctattgtta tccctccttt tggcgaatac     1920

cccgctttga cccttcaccc ctggatatat gggcagcagt acaccttctt cagcatggat     1980

gaaccaggca gtgagcagtt cacggtactt gcagacgtcc tcctgaataa gccaggcttt     2040

ggcaaccgct gcctgaagga agggtggctt ccggagtacc cctgtggcaa ctcaacaccc     2100

tggaagactc cttctgtgtc cccaaacatc acccagctgt tccagaagca gaaatggaca     2160

caggtcaacc cttcaccatc ctgcaggtgc agcaccaggg agaagctcac catgctgcca     2220

gagtgccccg agggtgccgg gggcctcccg cccccccaga gaacacagcg cagcacggaa     2280

attctacaag acctgacgga caggaacatc tccgacttct tggtaaaaac gtatcctgct     2340

cttataagaa gcagcttaaa gagcaaattc tgggtcaatg aacagaggta tggaggaatt     2400

tccattggag gaaagctccc agtcgtcccc atcacggggg aagcacttgt tgggttttta     2460

agcgaccttg gccggatcat gaatgtgagc gggggcccta tcactagaga ggcctctaaa     2520

gaaatacctg atttccttaa acatctagaa actgaagaca acattaaggt gtggtttaat     2580

aacaaaggct ggcatgccct ggtcagcttt ctcaatgtgg cccacaacgc catcttacgg     2640

gccagcctgc ctaaggacag gagccccgag gagtatggaa tcaccgtcat tagccaaccc     2700

ctgaacctga ccaaggagca gctctcagag attacagtgc tgaccacttc agtggatgct     2760

gtggttgcca tctgcgtgat tttctccatg tccttcgtcc cagccagctt tgtcctttat     2820

ttgatccagg agcgggtgaa caaatccaag cacctccagt ttatcagtgg agtgagcccc     2880

accacctact gggtgaccaa cttcctctgg gacatcatga attattccgt gagtgctggg     2940

ctggtggtgg gcatcttcat cgggtttcag aagaaagcct acacttctcc agaaaacctt     3000

cctgcccttg tggcactgct cctgctgtat ggatgggcgg tcattcccat gatgtaccca     3060

gcatccttcc tgtttgatgt ccccagcaca gcctatgtgg ctttatcttg tgctaatctg     3120

ttcatcggca tcaacagcag tgctattacc ttcatcttgg aattatttga gaataaccgg     3180

acgctgctca ggttcaacgc cgtgctgagg aagctgctca ttgtcttccc ccacttctgc     3240

ctgggccggg gcctcattga ccttgcactg agccaggctg tgacagatgt ctatgcccgg     3300

tttggtgagg agcactctgc aaatccgttc cactgggacc tgattgggaa gaacctgttt     3360

gccatggtgg tggaaggggt ggtgtacttc ctcctgaccc tgctggtcca gcgccacttc     3420

ttcctctccc aatggattgc cgagcccact aaggagccca ttgttgatga agatgatgat     3480

gtggctgaag aaagacaaag aattattact ggtggaaata aaactgacat cttaaggcta     3540

catgaactaa ccaagattta tccaggcacc tccagcccag cagtggacag gctgtgtgtc     3600

ggagttcgcc ctggagagtg ctttggcctc ctgggagtga atggtgccgg caaaacaacc     3660

acattcaaga tgctcactgg ggacaccaca gtgacctcag gggatgccac cgtagcaggc     3720

aagagtattt taaccaatat ttctgaagtc catcaaaata tgggctactg tcctcagttt     3780

gatgcaattg atgagctgct cacaggacga gaacatcttt acctttatgc ccggcttcga     3840

ggtgtaccag cagaagaaat cgaaaaggtt gcaaactgga gtattaagag cctgggcctg     3900

actgtctacg ccgactgcct ggctggcacg tacagtgggg gcaacaagcg gaaactctcc     3960

acagccatcg cactcattgg ctgcccaccg ctggtgctgc tggatgagcc caccacaggg     4020

atggaccccc aggcacgccg catgctgtgg aacgtcatcg tgagcatcat cagagaaggg     4080

agggctgtgg tcctcacatc ccacagcatg gaagaatgtg aggcactgtg tacccggctg     4140

gccatcatgg taaagggcgc ctttcgatgt atgggcacca ttcagcatct caagtccaaa     4200

tttggagatg gctatatcgt cacaatgaag atcaaatccc cgaaggacga cctgcttcct     4260

gacctgaacc ctgtggagca gttcttccag gggaacttcc caggcagtgt gcagagggag     4320

aggcactaca acatgctcca gttccaggtc tcctcctcct ccctggcgag gatcttccag     4380

ctcctcctct cccacaagga cagcctgctc atcgaggagt actcagtcac acagaccaca     4440

ctggaccagg tgtttgtaaa ttttgctaaa cagcagactg aaagtcatga cctccctctg     4500

caccctcgag ctgctggagc cagtcgacaa gcccaggact gagtcgacgc ggccgcgcag     4560

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata     4620

agctgcaata aacaagttct cgagttaagg gcgaattccc gattaggatc ttcctagagc     4680

atggctacgt agataagtag catggcgggt taatcattaa ctacaaggaa cccctagtga     4740

tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg     4800

tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcag          4855


<210> 21
<211> 4390
<212> DNA
<213> Unknown


<220> 
<223> Sequence shown in Figure 7

<400> 21
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagcaa aagactaaaa      240

gagggaggga tcacttcaga tctgccgagt gagtcgattg gacttaaagg gccagtcaaa      300

ccctgactgc cggctcatgg caggctcttg ccgaggacaa atgcccagcc tatatttatg      360

caaagagatt ttgttccaaa cttaaggtca aagataccta aagacatccc cctcaggaac      420

ccctctcatg gaggagagtg cctgagggtc ttggtttccc attgcatccc ccacctcaat      480

ttccctggtg cccagccact tgtgtcttta gggttctctt tctctccata aaagggagcc      540

aacacagtgt cggcctcctc tccccaacta agggcttatg tgtaattaaa agggattatg      600

ctttgaaggg gaaaagtagc ctttaatcac caggagaagg acacagcgtc cggagccaga      660

ggcgctctta acggcgttta tgtcctttgc tgtctgaggg gcctcagctc tgaccaatct      720

ggtcttcgtg tggtcattag cggtaccggt accaccggtg ccaccatggg cttcgtgaga      780

cagatacagc ttttgctctg gaagaactgg accctgcgga aaaggcaaaa gattcgcttt      840

gtggtggaac tcgtgtggcc tttatcttta tttctggtct tgatctggtt aaggaatgcc      900

aacccactct acagccatca tgaatgccat ttccccaaca aggcgatgcc ctcagcagga      960

atgctgccgt ggctccaggg gatcttctgc aatgtgaaca atccctgttt tcaaagcccc     1020

accccaggag aatctcctgg aattgtgtca aactataaca actccatctt ggcaagggta     1080

tatcgagatt ttcaagaact cctcatgaat gcaccagaga gccagcacct tggccgtatt     1140

tggacagagc tacacatctt gtcccaattc atggacaccc tccggactca cccggagaga     1200

attgcaggaa gaggaatacg aataagggat atcttgaaag atgaagaaac actgacacta     1260

tttctcatta aaaacatcgg cctgtctgac tcagtggtct accttctgat caactctcaa     1320

gtccgtccag agcagttcgc tcatggagtc ccggacctgg cgctgaagga catcgcctgc     1380

agcgaggccc tcctggagcg cttcatcatc ttcagccaga gacgcggggc aaagacggtg     1440

cgctatgccc tgtgctccct ctcccagggc accctacagt ggatagaaga cactctgtat     1500

gccaacgtgg acttcttcaa gctcttccgt gtgcttccca cactcctaga cagccgttct     1560

caaggtatca atctgagatc ttggggagga atattatctg atatgtcacc aagaattcaa     1620

gagtttatcc atcggccgag tatgcaggac ttgctgtggg tgaccaggcc cctcatgcag     1680

aatggtggtc cagagacctt tacaaagctg atgggcatcc tgtctgacct cctgtgtggc     1740

taccccgagg gaggtggctc tcgggtgctc tccttcaact ggtatgaaga caataactat     1800

aaggcctttc tggggattga ctccacaagg aaggatccta tctattctta tgacagaaga     1860

acaacatcct tttgtaatgc attgatccag agcctggagt caaatccttt aaccaaaatc     1920

gcttggaggg cggcaaagcc tttgctgatg ggaaaaatcc tgtacactcc tgattcacct     1980

gcagcacgaa ggatactgaa gaatgccaac tcaacttttg aagaactgga acacgttagg     2040

aagttggtca aagcctggga agaagtaggg ccccagatct ggtacttctt tgacaacagc     2100

acacagatga acatgatcag agataccctg gggaacccaa cagtaaaaga ctttttgaat     2160

aggcagcttg gtgaagaagg tattactgct gaagccatcc taaacttcct ctacaagggc     2220

cctcgggaaa gccaggctga cgacatggcc aacttcgact ggagggacat atttaacatc     2280

actgatcgca ccctccgcct ggtcaatcaa tacctggagt gcttggtcct ggataagttt     2340

gaaagctaca atgatgaaac tcagctcacc caacgtgccc tctctctact ggaggaaaac     2400

atgttctggg ccggagtggt attccctgac atgtatccct ggaccagctc tctaccaccc     2460

cacgtgaagt ataagatccg aatggacata gacgtggtgg agaaaaccaa taagattaaa     2520

gacaggtatt gggattctgg tcccagagct gatcccgtgg aagatttccg gtacatctgg     2580

ggcgggtttg cctatctgca ggacatggtt gaacagggga tcacaaggag ccaggtgcag     2640

gcggaggctc cagttggaat ctacctccag cagatgccct acccctgctt cgtggacgat     2700

tctttcatga tcatcctgaa ccgctgtttc cctatcttca tggtgctggc atggatctac     2760

tctgtctcca tgactgtgaa gagcatcgtc ttggagaagg agttgcgact gaaggagacc     2820

ttgaaaaatc agggtgtctc caatgcagtg atttggtgta cctggttcct ggacagcttc     2880

tccatcatgt cgatgagcat cttcctcctg acgatattca tcatgcatgg aagaatccta     2940

cattacagcg acccattcat cctcttcctg ttcttgttgg ctttctccac tgccaccatc     3000

atgctgtgct ttctgctcag caccttcttc tccaaggcca gtctggcagc agcctgtagt     3060

ggtgtcatct atttcaccct ctacctgcca cacatcctgt gcttcgcctg gcaggaccgc     3120

atgaccgctg agctgaagaa ggctgtgagc ttactgtctc cggtggcatt tggatttggc     3180

actgagtacc tggttcgctt tgaagagcaa ggcctggggc tgcagtggag caacatcggg     3240

aacagtccca cggaagggga cgaattcagc ttcctgctgt ccatgcagat gatgctcctt     3300

gatgctgctg tctatggctt actcgcttgg taccttgatc aggtgtttcc aggagactat     3360

ggaaccccac ttccttggta ctttcttcta caagagtcgt attggcttgg cggtgaaggg     3420

tgttcaacca gagaagaaag agccctggaa aagaccgagc ccctaacaga ggaaacggag     3480

gatccagagc acccagaagg aatacacgac tccttctttg aacgtgagca tccagggtgg     3540

gttcctgggg tatgcgtgaa gaatctggta aagatttttg agccctgtgg ccggccagct     3600

gtggaccgtc tgaacatcac cttctacgag aaccagatca ccgcattcct gggccacaat     3660

ggagctggga aaaccaccac cttgtccatc ctgacgggtc tgttgccacc aacctctggg     3720

actgtgctcg ttgggggaag ggacattgaa accagcctgg atgcagtccg gcagagcctt     3780

ggcatgtgtc cacagcacaa catcctgttc caccacctca cggtggctga gcacatgctg     3840

ttctatgccc agctgaaagg aaagtcccag gaggaggccc agctggagat ggaagccatg     3900

ttggaggaca caggcctcca ccacaagcgg aatgaagagg ctcaggacct atcaggtggc     3960

atgcagagaa agctgtcggt tgccattgcc tttgtgggag atgccaaggt aagggcactg     4020

agcagaaggg aagaagctcc gggggctctt tgtagggtaa gcttagtgca tcaaggcgat     4080

cacatcagtg aaaaaaagcc agacaggcgg ttaaaccaac gcagattaaa cagcaggatg     4140

caaaaattcg caggtggtca gatgaagctt attctcgagt taagggcgaa ttcccgatta     4200

ggatcttcct agagcatggc tacgtagata agtagcatgg cgggttaatc attaactaca     4260

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     4320

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     4380

gagcgcgcag                                                            4390


<210> 22
<211> 4790
<212> DNA
<213> Unknown


<220> 
<223> Sequence shown in Figure 8

<400> 22
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagcaa aagactaaaa      240

gagggaggga tcacttcaga tctgccgagt gagtcgattg gacttaaagg gccagtcaaa      300

ccctgactgc cggctcatgg caggctcttg ccgaggacaa atgcccagcc tatatttatg      360

caaagagatt ttgttccaaa cttaaggtca aagataccta aagacatccc cctcaggaac      420

ccctctcatg gaggagagtg cctgagggtc ttggtttccc attgcatccc ccacctcaat      480

ttccctggtg cccagccact tgtgtcttta gggttctctt tctctccata aaagggagcc      540

aacacagtgt cggcctcctc tccccaacta agggcttatg tgtaattaaa agggattatg      600

ctttgaaggg gaaaagtagc ctttaatcac caggagaagg acacagcgtc cggagccaga      660

ggcgctctta acggcgttta tgtcctttgc tgtctgaggg gcctcagctc tgaccaatct      720

ggtcttcgtg tggtcattag cggtaccggt accaccggta gaaagcttca tctgaccacc      780

tgcgaatttt tgcatcctgc tgtttaatct gcgttggttt aaccgcctgt ctggcttttt      840

ttcactgatg tgatcgcctt gatgcactaa gcttcaacga gtcttttgtc atctacaggt      900

ggtgattctg gacgaaccca cctctggggt ggacccttac tcgagacgct caatctggga      960

tctgctcctg aagtatcgct caggcagaac catcatcatg tccactcacc acatggacga     1020

ggccgacctc cttggggacc gcattgccat cattgcccag ggaaggctct actgctcagg     1080

caccccactc ttcctgaaga actgctttgg cacaggcttg tacttaacct tggtgcgcaa     1140

gatgaaaaac atccagagcc aaaggaaagg cagtgagggg acctgcagct gctcgtctaa     1200

gggtttctcc accacgtgtc cagcccacgt cgatgaccta actccagaac aagtcctgga     1260

tggggatgta aatgagctga tggatgtagt tctccaccat gttccagagg caaagctggt     1320

ggagtgcatt ggtcaagaac ttatcttcct tcttccaaat aagaacttca agcacagagc     1380

atatgccagc cttttcagag agctggagga gacgctggct gaccttggtc tcagcagttt     1440

tggaatttct gacactcccc tggaagagat ttttctgaag gtcacggagg attctgattc     1500

aggacctctg tttgcgggtg gcgctcagca gaaaagagaa aacgtcaacc cccgacaccc     1560

ctgcttgggt cccagagaga aggctggaca gacaccccag gactccaatg tctgctcccc     1620

aggggcgccg gctgctcacc cagagggcca gcctccccca gagccagagt gcccaggccc     1680

gcagctcaac acggggacac agctggtcct ccagcatgtg caggcgctgc tggtcaagag     1740

attccaacac accatccgca gccacaagga cttcctggcg cagatcgtgc tcccggctac     1800

ctttgtgttt ttggctctga tgctttctat tgttatccct ccttttggcg aataccccgc     1860

tttgaccctt cacccctgga tatatgggca gcagtacacc ttcttcagca tggatgaacc     1920

aggcagtgag cagttcacgg tacttgcaga cgtcctcctg aataagccag gctttggcaa     1980

ccgctgcctg aaggaagggt ggcttccgga gtacccctgt ggcaactcaa caccctggaa     2040

gactccttct gtgtccccaa acatcaccca gctgttccag aagcagaaat ggacacaggt     2100

caacccttca ccatcctgca ggtgcagcac cagggagaag ctcaccatgc tgccagagtg     2160

ccccgagggt gccgggggcc tcccgccccc ccagagaaca cagcgcagca cggaaattct     2220

acaagacctg acggacagga acatctccga cttcttggta aaaacgtatc ctgctcttat     2280

aagaagcagc ttaaagagca aattctgggt caatgaacag aggtatggag gaatttccat     2340

tggaggaaag ctcccagtcg tccccatcac gggggaagca cttgttgggt ttttaagcga     2400

ccttggccgg atcatgaatg tgagcggggg ccctatcact agagaggcct ctaaagaaat     2460

acctgatttc cttaaacatc tagaaactga agacaacatt aaggtgtggt ttaataacaa     2520

aggctggcat gccctggtca gctttctcaa tgtggcccac aacgccatct tacgggccag     2580

cctgcctaag gacaggagcc ccgaggagta tggaatcacc gtcattagcc aacccctgaa     2640

cctgaccaag gagcagctct cagagattac agtgctgacc acttcagtgg atgctgtggt     2700

tgccatctgc gtgattttct ccatgtcctt cgtcccagcc agctttgtcc tttatttgat     2760

ccaggagcgg gtgaacaaat ccaagcacct ccagtttatc agtggagtga gccccaccac     2820

ctactgggtg accaacttcc tctgggacat catgaattat tccgtgagtg ctgggctggt     2880

ggtgggcatc ttcatcgggt ttcagaagaa agcctacact tctccagaaa accttcctgc     2940

ccttgtggca ctgctcctgc tgtatggatg ggcggtcatt cccatgatgt acccagcatc     3000

cttcctgttt gatgtcccca gcacagccta tgtggcttta tcttgtgcta atctgttcat     3060

cggcatcaac agcagtgcta ttaccttcat cttggaatta tttgagaata accggacgct     3120

gctcaggttc aacgccgtgc tgaggaagct gctcattgtc ttcccccact tctgcctggg     3180

ccggggcctc attgaccttg cactgagcca ggctgtgaca gatgtctatg cccggtttgg     3240

tgaggagcac tctgcaaatc cgttccactg ggacctgatt gggaagaacc tgtttgccat     3300

ggtggtggaa ggggtggtgt acttcctcct gaccctgctg gtccagcgcc acttcttcct     3360

ctcccaatgg attgccgagc ccactaagga gcccattgtt gatgaagatg atgatgtggc     3420

tgaagaaaga caaagaatta ttactggtgg aaataaaact gacatcttaa ggctacatga     3480

actaaccaag atttatccag gcacctccag cccagcagtg gacaggctgt gtgtcggagt     3540

tcgccctgga gagtgctttg gcctcctggg agtgaatggt gccggcaaaa caaccacatt     3600

caagatgctc actggggaca ccacagtgac ctcaggggat gccaccgtag caggcaagag     3660

tattttaacc aatatttctg aagtccatca aaatatgggc tactgtcctc agtttgatgc     3720

aattgatgag ctgctcacag gacgagaaca tctttacctt tatgcccggc ttcgaggtgt     3780

accagcagaa gaaatcgaaa aggttgcaaa ctggagtatt aagagcctgg gcctgactgt     3840

ctacgccgac tgcctggctg gcacgtacag tgggggcaac aagcggaaac tctccacagc     3900

catcgcactc attggctgcc caccgctggt gctgctggat gagcccacca cagggatgga     3960

cccccaggca cgccgcatgc tgtggaacgt catcgtgagc atcatcagag aagggagggc     4020

tgtggtcctc acatcccaca gcatggaaga atgtgaggca ctgtgtaccc ggctggccat     4080

catggtaaag ggcgcctttc gatgtatggg caccattcag catctcaagt ccaaatttgg     4140

agatggctat atcgtcacaa tgaagatcaa atccccgaag gacgacctgc ttcctgacct     4200

gaaccctgtg gagcagttct tccaggggaa cttcccaggc agtgtgcaga gggagaggca     4260

ctacaacatg ctccagttcc aggtctcctc ctcctccctg gcgaggatct tccagctcct     4320

cctctcccac aaggacagcc tgctcatcga ggagtactca gtcacacaga ccacactgga     4380

ccaggtgttt gtaaattttg ctaaacagca gactgaaagt catgacctcc ctctgcaccc     4440

tcgagctgct ggagccagtc gacaagccca ggactgagtc gacgcggccg cgcagtgaaa     4500

aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg     4560

caataaacaa gttctcgagt taagggcgaa ttcccgatta ggatcttcct agagcatggc     4620

tacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag     4680

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     4740

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                4790


<210> 23
<211> 240
<212> DNA
<213> Unknown


<220> 
<223> ASS sequence

<400> 23
ctcggcagcc accttggctg ttcccaagtc cctcacaggc agggtctccc tacctgcctg     60

tcctcaggta catccccgag ggcctgcagt gctcgtgtgg aatcgactac tacacgctca    120

agccggaggt caacaacgag tcttttgtca tctacatgtt cgtggtccac ttcaccatcc    180

ccatgattat catctttttc tgctatgggc agctcgtctt caccgtcaag gaggtacggg    240


<210> 24
<211> 240
<212> DNA
<213> Unknown


<220> 
<223> ASS sequence

<400> 24
ctcggcagcc accttggctg ttcccaagtc cctcacaggc agggtctccc tacctgcctg     60

tcctcaggta catccccgag ggcctgcagt gctcgtgtgg aatcgactac tacacgctca    120

agccggaggt caacaacgag tcttttgtca tctacaggtt cgtggtccac ttcaccatcc    180

ccatgattat catctttttc tgctatgggc agctcgtctt caccgtcaag gaggtacggg    240


<210> 25
<211> 50
<212> DNA
<213> Unknown


<220> 
<223> ASS sequence

<400> 25
ctacacgctc aagccggagg tcaacaacga gtcttttgtc atctacatgt                50


<210> 26
<211> 27
<212> DNA
<213> Unknown


<220> 
<223> ASS sequence

<400> 26
gtcttttgtc atctacaggt gttcgtg                                        27


<210> 27
<211> 102
<212> DNA
<213> Artificial Sequence


<220> 
<223> binding domain BD_g

<400> 27
gttccaggga gggaatgtga agccccagaa agggccagcg ccaggtggaa ttcgctagct     60

cggcagccac cttggctgtt cccaagtccc tcacaggcag gg                       102


<210> 28
<211> 105
<212> DNA
<213> Artificial Sequence


<220> 
<223> Binding domain BD_h+i

<400> 28
gttaaccctc cagtcaggac tcaaacccag tagtgtctgg ttccaggcac tgacctgcta     60

gctcggcagc caccttggct gttcccaagt ccctcacagg caggg                    105


<210> 29
<211> 149
<212> DNA
<213> Artificial Sequence


<220> 
<223> Binding domain PTM1, B2

<400> 29
caccattcat ggtgatagcc gggctgctgt ttgtgcaggg ctggcactga acactgcctt     60

gatcttattt ggagcaatat gcgcttgtct aatttcacag caagaaaact gagctgaggc    120

tcaaagaagt caagcgccct gctggggcg                                      149


<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR2 forward primer

<400> 30
ggaaccccta gtgatggagt t                                              21


<210> 31
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR2 reverse primer

<400> 31
cggcctcagt gagcga                                                    16


<210> 32
<211> 100
<212> DNA
<213> Artificial Sequence


<220> 
<223> Binding domain BD_j

<400> 32
catctgacca ccagcgaatt tttgcatcca gctgtttaat cagcgttggt ttaaccgcca     60

gtcaggcttt ctttcaaaga tgtgatcgcc ttgcagcact                          100


<210> 33
<211> 100
<212> DNA
<213> Artificial Sequence


<220> 
<223> Binding domain BD_I

<400> 33
ccatcccgca tctgaccacc agcgaaatgg atttttgcat ccagctgggt aacgttggca     60

atttaaccgc cagtcaggct ttctttcaaa gatgtggatt                          100


<210> 34
<211> 100
<212> DNA
<213> Artificial Sequence


<220> 
<223> Binding domain BD_m

<400> 34
ccatcccgca tctgaccacc tgcgaaatgg atttttgcat cctgctgggt aacgttggca     60

atttaaccgc ctgtctggct ttctttcaat gatgtggatt                          100


<210> 35
<211> 1324
<212> DNA
<213> Artificial Sequence


<220> 
<223> 5' cerulean + BD_g

<400> 35
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc      60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc     240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat     360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc     420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt     480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa     540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctctctgg ctaactagag     600

aacccactgc ttactggctt atcgaaatta atacgactca ctatagggag acccaagctg     660

gctagttaag cttatggtga gcaagggcga ggagctgttc accggggtgg tgcccatcct     720

ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg     780

cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accacaggta agggcactga     840

gcagaaggga agaagctccg ggggctcttt gtagggtgga tccccctgcc tgtgagggac     900

ttgggaacag ccaaggtggc tgccgagcta gcgaattcca cctggcgctg gccctttctg     960

gggcttcaca ttccctccct ggaacggatc cctcgaggtc acccattcga acaaaaactc    1020

atctcagaag aggatctgaa tatgcatacc ggtcatcatc accatcacca ttgagtttaa    1080

acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc    1140

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag    1200

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag    1260

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct    1320

atgg                                                                 1324


<210> 36
<211> 1710
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3' cerulean + BD_g

<400> 36
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc      60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc     240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat     360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc     420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt     480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa     540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctctctgg ctaactagag     600

aacccactgc ttactggctt atcgaaatta atacgactca ctatagggag acccaagctg     660

gctagttaag cttggatccg ttccagggag ggaatgtgaa gccccagaaa gggccagcgc     720

caggtggaat tcgctagctc ggcagccacc ttggctgttc ccaagtccct cacaggcagg     780

gggatcccaa cgagtctttt gtcatctaca ggtaagctgc ccgtgccctg gcccaccctc     840

gtgaccaccc tgacctgggg cgtgcagtgc ttcgcccgct accccgacca catgaagcag     900

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc     960

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg    1020

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag    1080

ctggagtaca acgccatcag cgacaacgtc tatatcaccg ccgacaagca gaagaacggc    1140

atcaaggcca acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac    1200

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac    1260

ctgagcaccc agtccaagct gagcaaagac cccaacgaga agcgcgatca catggtcctg    1320

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaactc    1380

gaggtcaccc attcgaacaa aaactcatct cagaagagga tctgaatatg cataccggtc    1440

atcatcacca tcaccattga gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt    1500

gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc    1560

ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt    1620

ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca    1680

ggcatgctgg ggatgcggtg ggctctatgg                                     1710


<210> 37
<211> 3142
<212> DNA
<213> Artificial Sequence


<220> 
<223> 5' SpCas9-VPR + BD_k

<400> 37
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc      60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc     240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat     360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc     420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt     480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa     540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc     600

agaaccggtc gactagagga tccatggccc caaagaagaa gcggaaggtc ggtatccacg     660

gagtcccagc agccgacaag aagtactcca ttgggctcgc tatcggcaca aacagcgtcg     720

gctgggccgt cattacggac gagtacaagg tgccgagcaa aaaattcaaa gttctgggca     780

ataccgatcg ccacagcata aagaagaacc tcattggcgc cctcctgttc gactccgggg     840

aaacggccga agccacgcgg ctcaaaagaa cagcacggcg cagatatacc cgcagaaaga     900

atcggatctg ctacctgcag gagatcttta gtaatgagat ggctaaggtg gatgactctt     960

tcttccatag gctggaggag tcctttttgg tggaggagga taaaaagcac gagcgccacc    1020

caatctttgg caatatcgtg gacgaggtgg cgtaccatga aaagtaccca accatatatc    1080

atctgaggaa gaagcttgta gacagtactg ataaggctga cttgcggttg atctatctcg    1140

cgctggcgca tatgatcaaa tttcggggac acttcctcat cgagggggac ctgaacccag    1200

acaacagcga tgtcgacaaa ctctttatcc aactggttca gacttacaat cagcttttcg    1260

aagagaaccc gatcaacgca tccggagttg acgccaaagc aatcctgagc gctaggctgt    1320

ccaaatcccg gcggctcgaa aacctcatcg cacagctccc tggggagaag aagaacggcc    1380

tgtttggtaa tcttatcgcc ctgtcactcg ggctgacccc caactttaaa tctaacttcg    1440

acctggccga agatgccaag cttcaactga gcaaagacac ctacgatgat gatctcgaca    1500

atctgctggc ccagatcggc gaccagtacg cagacctttt tttggcggca aagaacctgt    1560

cagacgccat tctgctgagt gatattctgc gagtgaacac ggagatcacc aaagctccgc    1620

tgagcgctag tatgatcaag cgctatgatg agcaccacca agacttgact ttgctgaagg    1680

cccttgtcag acagcaactg cctgagaagt acaaggaaat tttcttcgat cagtctaaaa    1740

atggctacgc cggatacatt gacggcggag caagccagga ggaattttac aaatttatta    1800

agcccatctt ggaaaaaatg gacggcaccg aggagctgct ggtaaagctt aacagagaag    1860

atctgttgcg caaacagcgc actttcgaca atggaagcat cccccaccag attcacctgg    1920

gcgaactgca cgctatcctc aggcggcaag aggatttcta cccctttttg aaagataaca    1980

gggaaaagat tgagaaaatc ctcacatttc ggatacccta ctatgtaggc cccctcgccc    2040

ggggaaattc cagattcgcg tggatgactc gcaaatcaga agagaccatc actccctgga    2100

acttcgagga agtcgtggat aagggggcct ctgcccagtc cttcatcgaa aggatgacta    2160

actttgataa aaatctgcct aacgaaaagg tgcttcctaa acactctctg ctgtacgagt    2220

acttcacagt ttataacgag ctcaccaagg tcaaatacgt cacagaaggg atgagaaagc    2280

cagcattcct gtctggagag cagaagaaag ctatcgtgga cctcctcttc aagacgaacc    2340

ggaaagttac cgtgaaacag ctcaaagaag actatttcaa aaagattgaa tgtttcgact    2400

ctgttgaaat cagcggagtg gaggatcgct tcaacgcatc cctgggaacg tatcacgatc    2460

tcctgaaaat cattaaagac aaggacttcc tggacaatga ggagaacgag gacattcttg    2520

aggacattgt cctcaccctt acgttgtttg aagataggga gatgattgaa gaacgcttga    2580

aaacttacgc tcatctcttc gacgacaaag tcatgaaaca gctcaagagg cgccgatata    2640

caggatgggg gcggctgtca agaaaactga tcaatgggat ccgagacaag cagagtggaa    2700

agacaatcct ggattttctt aagtccgatg gatttgccaa ccggaacttc atgcagttga    2760

tccatgatga ctctctcacc tttaaggagg acatccagaa agcacaagtt tctggccagg    2820

gggacagtct tcacgagcac atcgctaatc ttgcaggtaa gggcactgag cagaagggaa    2880

gaagctccgg gggctctttg tagggtgcgg ccgcagtgca tcaaggcgat cacatcagtg    2940

aaaaaaagcc agacaggcgg ttaaaccaac gcagattaaa cagcaggatg caaaaattcg    3000

caggtggtca gatggcggcc gctctagact cgatgagttt ggacaaacca caactagaat    3060

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat    3120

tataagctgc aataaacaag tt                                             3142


<210> 38
<211> 4430
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3' SpCas9-VPR + BD_k

<400> 38
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      600

agaggtacca ccggtcgact agaggatccc ggccgccatc tgaccacctg cgaatttttg      660

catcctgctg tttaatctgc gttggtttaa ccgcctgtct ggcttttttt cactgatgtg      720

atcgccttga tgcactcggc cgccaacgag tcttttgtca tctacaggta gcccagctat      780

caaaaaggga atactgcaga ccgttaaggt cgtggatgaa ctcgtcaaag taatgggaag      840

gcataagccc gagaatatcg ttatcgagat ggcccgagag aaccaaacta cccagaaggg      900

acagaagaac agtagggaaa ggatgaagag gattgaagag ggtataaaag aactggggtc      960

ccaaatcctt aaggaacacc cagttgaaaa cacccagctt cagaatgaga agctctacct     1020

gtactacctg cagaacggca gggacatgta cgtggatcag gaactggaca tcaatcggct     1080

ctccgactac gacgtggatc atatcgtgcc ccagtctttt ctcaaagatg attctattga     1140

taataaagtg ttgacaagat ccgataaaaa tagagggaag agtgataacg tcccctcaga     1200

agaagttgtc aagaaaatga aaaattattg gcggcagctg ctgaacgcca aactgatcac     1260

acaacggaag ttcgataatc tgactaaggc tgaacgaggt ggcctgtctg agttggataa     1320

agccggcttc atcaaaaggc agcttgttga gacacgccag atcaccaagc acgtggccca     1380

aattctcgat tcacgcatga acaccaagta cgatgaaaat gacaaactga ttcgagaggt     1440

gaaagttatt actctgaagt ctaagctggt ctcagatttc agaaaggact ttcagtttta     1500

taaggtgaga gagatcaaca attaccacca tgcgcatgat gcctacctga atgcagtggt     1560

aggcactgca cttatcaaaa aatatcccaa gcttgaatct gaatttgttt acggagacta     1620

taaagtgtac gatgttagga aaatgatcgc aaagtctgag caggaaatag gcaaggccac     1680

cgctaagtac ttcttttaca gcaatattat gaattttttc aagaccgaga ttacactggc     1740

caatggagag attcggaagc gaccacttat cgaaacaaac ggagaaacag gagaaatcgt     1800

gtgggacaag ggtagggatt tcgcgacagt ccggaaggtc ctgtccatgc cgcaggtgaa     1860

catcgttaaa aagaccgaag tacagaccgg aggcttctcc aaggaaagta tcctcccgaa     1920

aaggaacagc gacaagctga tcgcacgcaa aaaagattgg gaccccaaga aatacggcgg     1980

attcgattct cctacagtcg cttacagtgt actggttgtg gccaaagtgg agaaagggaa     2040

gtctaaaaaa ctcaaaagcg tcaaggaact gctgggcatc acaatcatgg agcgatcaag     2100

cttcgaaaaa aaccccatcg actttctcga ggcgaaagga tataaagagg tcaaaaaaga     2160

cctcatcatt aagcttccca agtactctct ctttgagctt gaaaacggcc ggaaacgaat     2220

gctcgctagt gcgggcgagc tgcagaaagg taacgagctg gcactgccct ctaaatacgt     2280

taatttcttg tatctggcca gccactatga aaagctcaaa gggtctcccg aagataatga     2340

gcagaagcag ctgttcgtgg aacaacacaa acactacctt gatgagatca tcgagcaaat     2400

aagcgaattc tccaaaagag tgatcctcgc cgacgctaac ctcgataagg tgctttctgc     2460

ttacaataag cacagggata agcccatcag ggagcaggca gaaaacatta tccacttgtt     2520

tactctgacc aacttgggcg cgcctgcagc cttcaagtac ttcgacacca ccatagacag     2580

aaagcggtac acctctacaa aggaggtcct ggacgccaca ctgattcatc agtcaattac     2640

ggggctctat gaaacaagaa tcgacctctc tcagctcggt ggagacagca gggctgaccc     2700

caagaagaag aggaaggtgt cgccagggat ccgtcgactt gacgcgttga tatcaacaag     2760

tttgtacaaa aaagcaggct acaaagaggc cagcggttcc ggacgggctg acgcattgga     2820

cgattttgat ctggatatgc tgggaagtga cgccctcgat gattttgacc ttgacatgct     2880

tggttcggat gcccttgatg actttgacct cgacatgctc ggcagtgacg cccttgatga     2940

tttcgacctg gacatgctga ttaactctag aagttccgga tctccgaaaa agaaacgcaa     3000

agttggtagc cagtacctgc ccgacaccga cgaccggcac cggatcgagg aaaagcggaa     3060

gcggacctac gagacattca agagcatcat gaagaagtcc cccttcagcg gccccaccga     3120

ccctagacct ccacctagaa gaatcgccgt gcccagcaga tccagcgcca gcgtgccaaa     3180

acctgccccc cagccttacc ccttcaccag cagcctgagc accatcaact acgacgagtt     3240

ccctaccatg gtgttcccca gcggccagat ctctcaggcc tctgctctgg ctccagcccc     3300

tcctcaggtg ctgcctcagg ctcctgctcc tgcaccagct ccagccatgg tgtctgcact     3360

ggctcaggca ccagcacccg tgcctgtgct ggctcctgga cctccacagg ctgtggctcc     3420

accagcccct aaacctacac aggccggcga gggcacactg tctgaagctc tgctgcagct     3480

gcagttcgac gacgaggatc tgggagccct gctgggaaac agcaccgatc ctgccgtgtt     3540

caccgacctg gccagcgtgg acaacagcga gttccagcag ctgctgaacc agggcatccc     3600

tgtggcccct cacaccaccg agcccatgct gatggaatac cccgaggcca tcacccggct     3660

cgtgacaggc gctcagaggc ctcctgatcc agctcctgcc cctctgggag caccaggcct     3720

gcctaatgga ctgctgtctg gcgacgagga cttcagctct atcgccgata tggatttctc     3780

agccttgctg ggctctggca gcggcagccg ggattccagg gaagggatgt ttttgccgaa     3840

gcctgaggcc ggctccgcta ttagtgacgt gtttgagggc cgcgaggtgt gccagccaaa     3900

acgaatccgg ccatttcatc ctccaggaag tccatgggcc aaccgcccac tccccgccag     3960

cctcgcacca acaccaaccg gtccagtaca tgagccagtc gggtcactga ccccggcacc     4020

agtccctcag ccactggatc cagcgcccgc agtgactccc gaggccagtc acctgttgga     4080

ggatcccgat gaagagacga gccaggctgt caaagccctt cgggagatgg ccgatactgt     4140

gattccccag aaggaagagg ctgcaatctg tggccaaatg gacctttccc atccgccccc     4200

aaggggccat ctggatgagc tgacaaccac acttgagtcc atgaccgagg atctgaacct     4260

ggactcaccc ctgaccccgg aattgaacga gattctggat accttcctga acgacgagtg     4320

cctcttgcat gccatgcata tcagcacagg actgtccatc ttcgacacat ctctgttttg     4380

acaataaaat atctttattt tcattacatc tgtgtgttgg ttttttgtgt                4430


<210> 39
<211> 4775
<212> DNA
<213> Artificial Sequence


<220> 
<223> Dual AAV vector-5’ABCA4_w introns

<400> 39
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagcga cattgattat      240

tgactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt      300

tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc      360

cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac      420

gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata      480

tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc      540

agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta      600

ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac      660

ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc      720

aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc      780

gtgtacggtg ggaggtctat ataagcagag ctggtaccac cggtgccacc atgggcttcg      840

tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg caaaagattc      900

gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc tggttaagga      960

atgccaaccc actctacagc catcatgaat gccatttccc caacaaggcg atgccctcag     1020

caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc tgttttcaaa     1080

gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc atcttggcaa     1140

gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag caccttggcc     1200

gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg actcacccgg     1260

agagaattgc aggtaagtgg cgaccgtgcc ccacagccct agccgccctc cccactgccc     1320

gggcttaccc tggtcctgct cccgcaggaa gaggaatacg aataagggat atcttgaaag     1380

atgaagaaac actgacacta tttctcatta aaaacatcgg cctgtctgac tcagtggtct     1440

accttctgat caactctcaa gtccgtccag agcagttcgc tcatggagtc ccggacctgg     1500

cgctgaagga catcgcctgc agcgaggccc tcctggagcg cttcatcatc ttcagccaga     1560

gacgcggggc aaagacggtg cgctatgccc tgtgctccct ctcccagggc accctacagt     1620

ggatagaaga cactctgtat gccaacgtgg acttcttcaa gctcttccgt gtgcttccca     1680

cactcctaga cagccgttct caaggtatca atctgagatc ttggggagga atattatctg     1740

atatgtcacc aagaattcaa gagtttatcc atcggccgag tatgcaggac ttgctgtggg     1800

tgaccaggcc cctcatgcag aatggtggtc cagagacctt tacaaagctg atgggcatcc     1860

tgtctgacct cctgtgtggc taccccgagg gaggtggctc tcgggtgctc tccttcaact     1920

ggtatgaaga caataactat aaggcctttc tggggattga ctccacaagg aaggatccta     1980

tctattctta tgacagaaga acaacatcct tttgtaatgc attgatccag agcctggagt     2040

caaatccttt aaccaaaatc gcttggaggg cggcaaagcc tttgctgatg ggaaaaatcc     2100

tgtacactcc tgattcacct gcagcacgaa ggatactgaa gaatgccaac tcaacttttg     2160

aagaactgga acacgttagg aagttggtca aagcctggga agaagtaggg ccccagatct     2220

ggtacttctt tgacaacagc acacagatga acatgatcag agataccctg gggaacccaa     2280

cagtaaaaga ctttttgaat aggcagcttg gtgaagaagg tattactgct gaagccatcc     2340

taaacttcct ctacaagggc cctcgggaaa gccaggctga cgacatggcc aacttcgact     2400

ggagggacat atttaacatc actgatcgca ccctccgcct ggtcaatcaa tacctggagt     2460

gcttggtcct ggataagttt gaaagctaca atgatgaaac tcagctcacc caacgtgccc     2520

tctctctact ggaggaaaac atgttctggg ccggagtggt attccctgac atgtatccct     2580

ggaccagctc tctaccaccc cacgtgaagt ataagatccg aatggacata gacgtggtgg     2640

agaaaaccaa taagattaaa gacaggtgag tggactggag cctgggcacg aggtgtgggg     2700

tggcccctgc cctgccactt acaccacctg cctcttcctg caggtattgg gattctggtc     2760

ccagagctga tcccgtggaa gatttccggt acatctgggg cgggtttgcc tatctgcagg     2820

acatggttga acaggggatc acaaggagcc aggtgcaggc ggaggctcca gttggaatct     2880

acctccagca gatgccctac ccctgcttcg tggacgattc tttcatgatc atcctgaacc     2940

gctgtttccc tatcttcatg gtgctggcat ggatctactc tgtctccatg actgtgaaga     3000

gcatcgtctt ggagaaggag ttgcgactga aggagacctt gaaaaatcag ggtgtctcca     3060

atgcagtgat ttggtgtacc tggttcctgg acagcttctc catcatgtcg atgagcatct     3120

tcctcctgac gatattcatc atgcatggaa gaatcctaca ttacagcgac ccattcatcc     3180

tcttcctgtt cttgttggct ttctccactg ccaccatcat gctgtgcttt ctgctcagca     3240

ccttcttctc caaggccagt ctggcagcag cctgtagtgg tgtcatctat ttcaccctct     3300

acctgccaca catcctgtgc ttcgcctggc aggaccgcat gaccgctgag ctgaagaagg     3360

ctgtgagctt actgtctccg gtggcatttg gatttggcac tgagtacctg gttcgctttg     3420

aagagcaagg cctggggctg cagtggagca acatcgggaa cagtcccacg gaaggggacg     3480

aattcagctt cctgctgtcc atgcagatga tgctccttga tgctgctgtc tatggcttac     3540

tcgcttggta ccttgatcag gtgtttccag gagactatgg aaccccactt ccttggtact     3600

ttcttctaca agagtcgtat tggcttggcg gtgaaggtaa gtagtctgat tatacacaag     3660

atattgtcta gaacttgatg agactgtgga tatgaatatt tcactctttt ctcagggtgt     3720

tcaaccagag aagaaagagc cctggaaaag accgagcccc taacagagga aacggaggat     3780

ccagagcacc cagaaggaat acacgactcc ttctttgaac gtgagcatcc agggtgggtt     3840

cctggggtat gcgtgaagaa tctggtaaag atttttgagc cctgtggccg gccagctgtg     3900

gaccgtctga acatcacctt ctacgagaac cagatcaccg cattcctggg ccacaatgga     3960

gctgggaaaa ccaccacctt gtccatcctg acgggtctgt tgccaccaac ctctgggact     4020

gtgctcgttg ggggaaggga cattgaaacc agcctggatg cagtccggca gagccttggc     4080

atgtgtccac agcacaacat cctgttccac cacctcacgg tggctgagca catgctgttc     4140

tatgcccagc tgaaaggaaa gtcccaggag gaggcccagc tggagatgga agccatgttg     4200

gaggacacag gcctccacca caagcggaat gaagaggctc aggacctatc aggtggcatg     4260

cagagaaagc tgtcggttgc cattgccttt gtgggagatg ccaaggtaag ggcactgagc     4320

agaagggaag aagctccggg ggctctttgt agggtaagct tagtgcatca aggcgatcac     4380

atcagtgaaa aaaagccaga caggcggtta aaccaacgca gattaaacag caggatgcaa     4440

aaattcgcag gtggtcagat gaagcttatt gtcgaggcag tgaaaaaaat gctttatttg     4500

tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagttct     4560

cgagttaagg gcgaattccc gattaggatc ttcctagagc atggctacgt agataagtag     4620

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct     4680

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     4740

gcccgggcgg cctcagtgag cgagcgagcg cgcag                                4775


<210> 40
<211> 5092
<212> DNA
<213> Artificial Sequence


<220> 
<223> Dual AAV vector-3’ABCA4_w introns

<400> 40
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagcga cattgattat      240

tgactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt      300

tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc      360

cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac      420

gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata      480

tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc      540

agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta      600

ttaccatggt gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac      660

ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc      720

aacgggactt tccaaaatgt cgtaacaact ccgccccatt gacgcaaatg ggcggtaggc      780

gtgtacggtg ggaggtctat ataagcagag ctggtaccac cggtagaaag cttcatctga      840

ccacctgcga atttttgcat cctgctgttt aatctgcgtt ggtttaaccg cctgtctggc      900

tttttttcac tgatgtgatc gccttgatgc actaagcttc aacgagtctt ttgtcatcta      960

caggtggtga ttctggacga acccacctct ggggtggacc cttactcgag acgctcaatc     1020

tgggatctgc tcctgaagta tcgctcaggc agaaccatca tcatgtccac tcaccacatg     1080

gacgaggccg acctccttgg ggaccgcatt gccatcattg cccagggaag gctctactgc     1140

tcaggcaccc cactcttcct gaagaactgc tttggcacag gcttgtactt aaccttggtg     1200

cgcaagatga aaaacatcca gagccaaagg aaaggcagtg aggtgagtca ggctgggcgc     1260

ccccgccccc aggggccctc cctccccaag ccccccggac gcgcctcacc cacgttcctc     1320

tcgcagggga cctgcagctg ctcgtctaag ggtttctcca ccacgtgtcc agcccacgtc     1380

gatgacctaa ctccagaaca agtcctggat ggggatgtaa atgagctgat ggatgtagtt     1440

ctccaccatg ttccagaggc aaagctggtg gagtgcattg gtcaagaact tatcttcctt     1500

cttccaaata agaacttcaa gcacagagca tatgccagcc ttttcagaga gctggaggag     1560

acgctggctg accttggtct cagcagtttt ggaatttctg acactcccct ggaagagatt     1620

tttctgaagg tcacggagga ttctgattca ggacctctgt ttgcgggtgg cgctcagcag     1680

aaaagagaaa acgtcaaccc ccgacacccc tgcttgggtc ccagagagaa ggctggacag     1740

acaccccagg actccaatgt ctgctcccca ggggcgccgg ctgctcaccc agagggccag     1800

cctcccccag agccagagtg cccaggcccg cagctcaaca cggggacaca gctggtcctc     1860

cagcatgtgc aggcgctgct ggtcaagaga ttccaacaca ccatccgcag ccacaaggac     1920

ttcctggcgc agatcgtgct cccggctacc tttgtgtttt tggctctgat gctttctatt     1980

gttatccctc cttttggcga ataccccgct ttgacccttc acccctggat atatgggcag     2040

cagtacacct tcttcagcat ggatgaacca ggcagtgagc agttcacggt acttgcagac     2100

gtcctcctga ataagccagg ctttggcaac cgctgcctga aggaagggtg gcttccggag     2160

tacccctgtg gcaactcaac accctggaag actccttctg tgtccccaaa catcacccag     2220

ctgttccaga agcagaaatg gacacaggtc aacccttcac catcctgcag gtgcagcacc     2280

agggagaagc tcaccatgct gccagagtgc cccgagggtg ccgggggcct cccgcccccc     2340

cagagaacac agcgcagcac ggaaattcta caagacctga cggacaggaa catctccgac     2400

ttcttggtaa aaacgtatcc tgctcttata agaagcagct taaagagcaa attctgggtc     2460

aatgaacaga ggtatggagg aatttccatt ggaggaaagc tcccagtcgt ccccatcacg     2520

ggggaagcac ttgttgggtt tttaagcgac cttggccgga tcatgaatgt gagcgggggc     2580

cctatcacta gagaggcctc taaagaaata cctgatttcc ttaaacatct agaaactgaa     2640

gacaacatta aggtgtggtt taataacaaa ggctggcatg ccctggtcag ctttctcaat     2700

gtggcccaca acgccatctt gtaagtccta ccttttttgt tcctttgaaa gcctcctgga     2760

aagcttttcc tgaagtgttt gttctgtaat ttctttgcag acgggccagc ctgcctaagg     2820

acaggagccc cgaggagtat ggaatcaccg tcattagcca acccctgaac ctgaccaagg     2880

agcagctctc agagattaca gtgctgacca cttcagtgga tgctgtggtt gccatctgcg     2940

tgattttctc catgtccttc gtcccagcca gctttgtcct ttatttgatc caggagcggg     3000

tgaacaaatc caagcacctc cagtttatca gtggagtgag ccccaccacc tactgggtga     3060

ccaacttcct ctgggacatc atgaattatt ccgtgagtgc tgggctggtg gtgggcatct     3120

tcatcgggtt tcagaagaaa gcctacactt ctccagaaaa ccttcctgcc cttgtggcac     3180

tgctcctgct gtatggatgg gcggtcattc ccatgatgta cccagcatcc ttcctgtttg     3240

atgtccccag cacagcctat gtggctttat cttgtgctaa tctgttcatc ggcatcaaca     3300

gcagtgctat taccttcatc ttggaattat ttgagaataa ccggacgctg ctcaggttca     3360

acgccgtgct gaggaagctg ctcattgtct tcccccactt ctgcctgggc cggggcctca     3420

ttgaccttgc actgagccag gctgtgacag atgtctatgc ccggtttggt gaggagcact     3480

ctgcaaatcc gttccactgg gacctgattg ggaagaacct gtttgccatg gtggtggaag     3540

gggtggtgta cttcctcctg accctgctgg tccagcgcca cttcttcctc tcccaatgga     3600

ttgccgagcc cactaaggag cccattgttg atgaagatga tgatgtggct gaagaaagac     3660

aaagaattat tactggtgga aataaaactg acatcttaag gctacatgaa ctaaccaaga     3720

tttatccagg cacctccagc ccagcagtgg acaggctgtg tgtcggagtt cgccctggag     3780

agtgctttgg cctcctggga gtgaatggtg ccggcaaaac aaccacattc aagatgctca     3840

ctggggacac cacagtgacc tcaggggatg ccaccgtagc aggcaagagt attttaacca     3900

atatttctga agtccatcaa aatatgggct actgtcctca gtttgatgca attgatgagc     3960

tgctcacagg acgagaacat ctttaccttt atgcccggct tcgaggtgta ccagcagaag     4020

aaatcgaaaa ggtaagtgat tcctagggct ggggaaggtg ggtgggaatc ctctcctgct     4080

cacctcctct ctcctgcccc acaggttgca aactggagta ttaagagcct gggcctgact     4140

gtctacgccg actgcctggc tggcacgtac agtgggggca acaagcggaa actctccaca     4200

gccatcgcac tcattggctg cccaccgctg gtgctgctgg atgagcccac cacagggatg     4260

gacccccagg cacgccgcat gctgtggaac gtcatcgtga gcatcatcag agaagggagg     4320

gctgtggtcc tcacatccca cagcatggaa gaatgtgagg cactgtgtac ccggctggcc     4380

atcatggtaa agggcgcctt tcgatgtatg ggcaccattc agcatctcaa gtccaaattt     4440

ggagatggct atatcgtcac aatgaagatc aaatccccga aggacgacct gcttcctgac     4500

ctgaaccctg tggagcagtt cttccagggg aacttcccag gcagtgtgca gagggagagg     4560

cactacaaca tgctccagtt ccaggtctcc tcctcctccc tggcgaggat cttccagctc     4620

ctcctctccc acaaggacag cctgctcatc gaggagtact cagtcacaca gaccacactg     4680

gaccaggtgt ttgtaaattt tgctaaacag cagactgaaa gtcatgacct ccctctgcac     4740

cctcgagctg ctggagccag tcgacaagcc caggactgag tcgacgcggc cgcgcagtga     4800

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     4860

tgcaataaac aagttctcga gttaagggcg aattcccgat taggatcttc ctagagcatg     4920

gctacgtaga taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg     4980

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     5040

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             5092


