               SEQUENCE LISTING



<110> AVA Lifescience GmbH



<120> Verfahren zur Selektion biologischer Bindemoleküle



<130> Prio vom 20.12.2018



<160> 12



<170> BiSSAP 1.3.6



<210> 1

<211> 221

<212> PRT

<213> Homo sapiens





<400> 1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 

            20                  25                  30          

Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              

Ser Ser Ile Ile Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 

    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 

65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 

                85                  90                  95      

Ala Arg Asp Gln Asn Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val 

            100                 105                 110         

Thr Val Ser Ser Asp Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val 

        115                 120                 125             

Ser Cys Glu Asn Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys 

    130                 135                 140                 

Leu Ala Gln Asp Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr 

145                 150                 155                 160 

Lys Asn Asn Ser Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu 

                165                 170                 175     

Arg Gly Gly Lys Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys 

            180                 185                 190         

Asp Val Met Gln Gly Thr Asp Glu His Val Val Cys Lys Val Gln His 

        195                 200                 205             

Pro Asn Gly Asn Lys Glu Lys Asn Val Pro Leu Pro Val 

    210                 215                 220     



<210> 2

<211> 246

<212> PRT

<213> Homo sapiens





<400> 2

Ile Arg Ser Leu Glu Ala Thr Met Ala Trp Thr Val Leu Leu Leu Gly 

1               5                   10                  15      

Leu Leu Ser His Cys Thr Gly Ser Val Thr Ser Tyr Glu Leu Thr Gln 

            20                  25                  30          

Pro Pro Ser Val Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys 

        35                  40                  45              

Ala Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys 

    50                  55                  60                  

Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Tyr Asp Ser Asp Arg Pro 

65                  70                  75                  80  

Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala 

                85                  90                  95      

Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 

            100                 105                 110         

Cys Gln Val Trp Asp Ser Gly Ser Asp His Pro Trp Val Phe Gly Gly 

        115                 120                 125             

Gly Thr Lys Leu Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val 

    130                 135                 140                 

Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr 

145                 150                 155                 160 

Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala 

                165                 170                 175     

Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr 

            180                 185                 190         

Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser 

        195                 200                 205             

Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val 

    210                 215                 220                 

Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys 

225                 230                 235                 240 

Ser Glu Phe Arg Pro Ser 

                245     



<210> 3

<211> 221

<212> PRT

<213> Homo sapiens





<400> 3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 

1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 

            20                  25                  30          

Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 

        35                  40                  45              

Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 

    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 

65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 

                85                  90                  95      

Ala Arg Asp Gln Asn Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val 

            100                 105                 110         

Thr Val Ser Ser Asp Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val 

        115                 120                 125             

Ser Cys Glu Asn Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys 

    130                 135                 140                 

Leu Ala Gln Asp Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr 

145                 150                 155                 160 

Lys Asn Asn Ser Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu 

                165                 170                 175     

Arg Gly Gly Lys Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys 

            180                 185                 190         

Asp Val Met Gln Gly Thr Asp Glu His Val Val Cys Lys Val Gln His 

        195                 200                 205             

Pro Asn Gly Asn Lys Glu Lys Asn Val Pro Leu Pro Val 

    210                 215                 220     



<210> 4

<211> 220

<212> PRT

<213> Homo sapiens





<400> 4

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 

1               5                   10                  15      

Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 

            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 

        35                  40                  45              

Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 

    50                  55                  60                  

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 

65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 

                85                  90                  95      

Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Gln Pro 

            100                 105                 110         

Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 

        115                 120                 125             

Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 

    130                 135                 140                 

Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 

145                 150                 155                 160 

Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 

                165                 170                 175     

Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 

            180                 185                 190         

Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 

        195                 200                 205             

Val Ala Pro Thr Glu Cys Ser Glu Phe Arg Pro Ser 

    210                 215                 220 



<210> 5

<211> 119

<212> PRT

<213> Homo sapiens





<400> 5

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 

1               5                   10                  15      

Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 

            20                  25                  30          

Gly Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 

        35                  40                  45              

Gly Val Ile Trp Arg Gly Gly Gly Thr Asp Ser Asn Ala Ala Phe Met 

    50                  55                  60                  

Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 

65                  70                  75                  80  

Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 

                85                  90                  95      

Arg Ser Arg Tyr Asp Glu Glu Glu Ser Met Asn Tyr Trp Gly Gln Gly 

            100                 105                 110         

Thr Ser Val Thr Val Ser Ser 

        115                 



<210> 6

<211> 107

<212> PRT

<213> Homo sapiens





<400> 6

Gln Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 

1               5                   10                  15      

Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Ser Tyr 

            20                  25                  30          

Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 

        35                  40                  45              

Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 

    50                  55                  60                  

Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 

65                  70                  75                  80  

Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Asn Thr Pro Pro 

                85                  90                  95      

Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 

            100                 105         



<210> 7

<211> 8

<212> PRT

<213> Homo sapiens





<400> 7

Gly Phe Ser Leu Thr Ser Tyr Gly 

1               5               



<210> 8

<211> 7

<212> PRT

<213> Homo sapiens





<400> 8

Ile Trp Arg Gly Gly Gly Thr 

1               5           



<210> 9

<211> 13

<212> PRT

<213> Homo sapiens





<400> 9

Ala Arg Ser Arg Tyr Asp Glu Glu Glu Ser Met Asn Tyr 

1               5                   10              



<210> 10

<211> 6

<212> PRT

<213> Homo sapiens





<400> 10

Gly Asn Ile His Ser Tyr 

1               5       



<210> 11

<211> 4

<212> PRT

<213> Homo sapiens





<400> 11

Asn Ala Lys Thr 

1               



<210> 12

<211> 9

<212> PRT

<213> Homo sapiens





<400> 12

Gln His Phe Trp Asn Thr Pro Pro Thr 

1               5                   



