                         SEQUENCE LISTING

<110>  ADC THERAPEUTICS SA
       MEDIMMUNE LIMITED
 
<120>  PYRROLOBENZODIAZEPINE RESISTANCE

<130>  007587868

<150>  GB 1820725.8
<151>  2018-12-19

<150>  GB 1904342.1
<151>  2019-03-18

<160>  135   

<170>  PatentIn version 3.5

<210>  1
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB12 VH

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ile Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Val Glu Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Asp Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125         


<210>  2
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB12 VL

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro 
        115                 


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB12 VH CDR1

<400>  3

Arg Tyr Ile Ile Asn 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB12 VH CDR2

<400>  4

Arg Ile Ile Pro Ile Leu Gly Val Glu Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB12 VH CDR3

<400>  5

Lys Asp Trp Phe Asp Tyr 
1               5       


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB12 VL CDR1

<400>  6

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB12 VL CDR2

<400>  7

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB12 VL CDR3

<400>  8

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  9

<400>  9
000

<210>  10

<400>  10
000

<210>  11
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RB4v1.0 VH

<400>  11

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Asn Pro Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser 
        115                 


<210>  12
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RB4v1.2 VH

<400>  12

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Gln Gly Lys Ala Lys Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Asn Pro Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser 
        115                 


<210>  13
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RB4v1.0 VK

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Gly Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Arg Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Gly Ser Tyr Thr Phe Gly 
                85                  90                  95      


Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 


<210>  14
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RB4v1.2 VK

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Gly Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Arg Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Gly Ser Tyr Thr Phe Gly 
                85                  90                  95      


Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 


<210>  15
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epratuzumab VH

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Tyr Thr Glu Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Asp Ile Thr Thr Phe Tyr Trp Gly Gln Gly 
            100                 105                 


<210>  16
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epratuzumab VL

<400>  16

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ala Asn His Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Trp Thr Phe Gly Gln Gly 
            100                 105     


<210>  17
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMabC220-HC

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Tyr Thr Glu Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Asp Ile Thr Thr Phe Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Val Pro Pro Val Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  18
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EMabC220-LC

<400>  18

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ala Asn His Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Ser 
    210                 215                 


<210>  19

<400>  19
000

<210>  20

<400>  20
000

<210>  21
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 VH

<400>  21

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 VL

<400>  22

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Met Leu Asp Leu Lys 
            100                 105         


<210>  23
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 VH DeIm

<400>  23

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  24
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591 VK DeIm

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  25
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591BJ DeIm heavy chain

<400>  25

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Val 
    210                 215                 220                 


Pro Pro Val Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  26
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  J591BJ DeIm light chain

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Pro Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Ser 
    210                 


<210>  27

<400>  27
000

<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H12 VH

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Pro Ile Tyr Tyr Thr Tyr Asp Asp Thr Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  32
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H12 VL

<400>  32

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Asn Phe His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  33
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H12 Heavy Chain


<220>
<221>  MISC_FEATURE
<222>  (302)..(302)
<223>  Xaa = Asn297 (numbering according to Kabat)

<400>  33

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Pro Ile Tyr Tyr Thr Tyr Asp Asp Thr Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  34
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H12 Light Chain

<400>  34

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Ser Gly 
            20                  25                  30          


Asn Phe His Trp Tyr Gln Gln Lys Pro Gly Leu Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H12 VH CDR1

<400>  35

Ser Tyr Gly Met Ser 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H12 VH CDR2

<400>  36

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H12 VH CDR3

<400>  37

His Pro Ile Tyr Tyr Thr Tyr Asp Asp Thr Met Asp Tyr 
1               5                   10              


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H12 VL CDR1

<400>  38

Ser Ala Ser Ser Ser Val Ser Ser Gly Asn Phe His 
1               5                   10          


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H12 VL CDR2

<400>  39

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1H12 VL CDR3

<400>  40

Gln Gln Trp Ser Gly Tyr Pro Trp Thr 
1               5                   


<210>  41
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d VH

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Tyr Gly Asn Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Arg Glu Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  42
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d VL

<400>  42

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  43
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d Heavy Chain


<220>
<221>  MISC_FEATURE
<222>  (301)..(301)
<223>  Xaa = Asn297

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Tyr Gly Asn Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Arg Glu Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  44
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d Light Chain

<400>  44

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d VH CDR1

<400>  45

Asp Tyr Ala Met His 
1               5   


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d VH CDR2

<400>  46

Val Ile Ser Thr Tyr Tyr Gly Asn Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d VH CDR3

<400>  47

Gly Gly Leu Arg Glu Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d VL CDR1

<400>  48

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d VL CDR2

<400>  49

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d VL CDR3

<400>  50

Gln Gln His Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  51
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HuBa-1-3d Heavy Chain, terminal K


<220>
<221>  MISC_FEATURE
<222>  (301)..(301)
<223>  Xaa = Asn297

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Tyr Tyr Gly Asn Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Arg Glu Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55

<400>  55
000

<210>  56

<400>  56
000

<210>  57

<400>  57
000

<210>  58

<400>  58
000

<210>  59

<400>  59
000

<210>  60

<400>  60
000

<210>  61
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 VH

<400>  61

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  62
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 VL

<400>  62

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  63
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 Heavy Chain


<220>
<221>  MISC_FEATURE
<222>  (296)..(297)
<223>  Xaa = Asn297

<400>  63

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  64
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 Light Chain

<400>  64

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 VH CDR1

<400>  65

Gly Tyr Thr Phe Thr Asp Asp Tyr Met Ser 
1               5                   10  


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 VH CDR2

<400>  66

Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn 
1               5                   10  


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 VH CDR3

<400>  67

Asp Pro Gly Ala Met Asp Tyr 
1               5           


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 VL CDR1

<400>  68

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 VL CDR2

<400>  69

Thr Val Ser Asn Arg Phe Ser 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 VL CDR3

<400>  70

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  71
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 Heavy Chain, terminal K


<220>
<221>  MISC_FEATURE
<222>  (296)..(296)
<223>  Xaa = Asn297

<400>  71

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  72
<211>  84
<212>  PRT
<213>  Homo sapiens KAAG1

<400>  72

Met Asp Asp Asp Ala Ala Pro Arg Val Glu Gly Val Pro Val Ala Val 
1               5                   10                  15      


His Lys His Ala Leu His Asp Gly Leu Arg Gln Val Ala Gly Pro Gly 
            20                  25                  30          


Ala Ala Ala Ala His Leu Pro Arg Trp Pro Pro Pro Gln Leu Ala Ala 
        35                  40                  45              


Ser Arg Arg Glu Ala Pro Pro Leu Ser Gln Arg Pro His Arg Thr Gln 
    50                  55                  60                  


Gly Ala Gly Ser Pro Pro Glu Thr Asn Glu Lys Leu Thr Asn Pro Gln 
65                  70                  75                  80  


Val Lys Glu Lys 
                


<210>  73
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4-L2 VL

<400>  73

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  74
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4-L2 Light Chain

<400>  74

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  75
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4-K4 VL

<400>  75

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  76
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4-K4 Light Chain

<400>  76

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  77

<400>  77
000

<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XA4 VH

<400>  81

Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Thr Phe Arg Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Leu Trp Tyr Asp Gly Ser His Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Tyr Tyr Asp Ser Gly Ser Pro Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  82
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XA4 VL

<400>  82

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  83
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XA4 Heavy Chain


<220>
<221>  MISC_FEATURE
<222>  (302)..(302)
<223>  Xaa = Asn297

<400>  83

Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Thr Phe Arg Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Leu Trp Tyr Asp Gly Ser His Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Tyr Tyr Asp Ser Gly Ser Pro Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  84
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XA4 Light Chain

<400>  84

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XA4 Heavy Chain, terminal K


<220>
<221>  MISC_FEATURE
<222>  (302)..(302)
<223>  Xaa = Asn297

<400>  91

Gln Val His Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Thr Phe Arg Ile Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Leu Trp Tyr Asp Gly Ser His Glu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Asp Tyr Tyr Asp Ser Gly Ser Pro Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  92
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XFT VH

<400>  92

Gln Val Glu Leu Val Gln Ser Gly Ala Val Lys Lys Pro Gly Glu Ser 
1               5                   10                  15      


Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp 
            20                  25                  30          


Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ile Ile Asp Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro Ser Phe Gln 
    50                  55                  60                  


Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gln Leu Tyr Gly Gly Thr Tyr Met Asp Gly Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  93
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XFT VL

<400>  93

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr 
            20                  25                  30          


Asn Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Ile Glu 
                85                  90                  95      


Ser Ala Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  94
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XFT Heavy Chain


<220>
<221>  MISC_FEATURE
<222>  (299)..(299)
<223>  Xaa = Asn297

<400>  94

Gln Val Glu Leu Val Gln Ser Gly Ala Val Lys Lys Pro Gly Glu Ser 
1               5                   10                  15      


Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp 
            20                  25                  30          


Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ile Ile Asp Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro Ser Phe Gln 
    50                  55                  60                  


Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gln Leu Tyr Gly Gly Thr Tyr Met Asp Gly Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  95
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XFT Light Chain

<400>  95

Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr 
            20                  25                  30          


Asn Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Ile Glu 
                85                  90                  95      


Ser Ala Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  96

<400>  96
000

<210>  97

<400>  97
000

<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101

<400>  101
000

<210>  102
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XFT Heavy Chain, terminal K


<220>
<221>  MISC_FEATURE
<222>  (299)..(299)
<223>  Xaa = Asn297

<400>  102

Gln Val Glu Leu Val Gln Ser Gly Ala Val Lys Lys Pro Gly Glu Ser 
1               5                   10                  15      


Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp 
            20                  25                  30          


Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ile Ile Asp Pro Gly Asp Ser Arg Thr Arg Tyr Ser Pro Ser Phe Gln 
    50                  55                  60                  


Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gln Leu Tyr Gly Gly Thr Tyr Met Asp Gly Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  103
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X09 VH

<400>  103

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  104
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X09 VL

<400>  104

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  105
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X09 Heavy Chain


<220>
<221>  MISC_FEATURE
<222>  (299)..(299)
<223>  Xaa = Asn297

<400>  105

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  106
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X09 Light Chain

<400>  106

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  107

<400>  107
000

<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X09 Heavy Chain, terminal K


<220>
<221>  MISC_FEATURE
<222>  (299)..(299)
<223>  Xaa = Asn297

<400>  113

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  114
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X09.2 VH

<400>  114

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  115
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X09.2 VL

<400>  115

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  116
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X09.2 Heavy Chain


<220>
<221>  MISC_FEATURE
<222>  (299)..(299)
<223>  Xaa = Asn297

<400>  116

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  117
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X09.2 Light Chain

<400>  117

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  118
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  X09.2 Heavy Chain, terminal K


<220>
<221>  MISC_FEATURE
<222>  (299)..(299)
<223>  Xaa = Asn297

<400>  118

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Xaa Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  119
<211>  655
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP-binding cassette sub-family G member 2 UniProt record number:
       Q9UNQ0

<400>  119

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


<210>  120
<211>  1545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP-binding cassette sub-family C (MRP) member 2 or Canalicular 
       multispecific organic anion transporter 1 UniProt record number: 
       Q92887

<400>  120

Met Leu Glu Lys Phe Cys Asn Ser Thr Phe Trp Asn Ser Ser Phe Leu 
1               5                   10                  15      


Asp Ser Pro Glu Ala Asp Leu Pro Leu Cys Phe Glu Gln Thr Val Leu 
            20                  25                  30          


Val Trp Ile Pro Leu Gly Tyr Leu Trp Leu Leu Ala Pro Trp Gln Leu 
        35                  40                  45              


Leu His Val Tyr Lys Ser Arg Thr Lys Arg Ser Ser Thr Thr Lys Leu 
    50                  55                  60                  


Tyr Leu Ala Lys Gln Val Phe Val Gly Phe Leu Leu Ile Leu Ala Ala 
65                  70                  75                  80  


Ile Glu Leu Ala Leu Val Leu Thr Glu Asp Ser Gly Gln Ala Thr Val 
                85                  90                  95      


Pro Ala Val Arg Tyr Thr Asn Pro Ser Leu Tyr Leu Gly Thr Trp Leu 
            100                 105                 110         


Leu Val Leu Leu Ile Gln Tyr Ser Arg Gln Trp Cys Val Gln Lys Asn 
        115                 120                 125             


Ser Trp Phe Leu Ser Leu Phe Trp Ile Leu Ser Ile Leu Cys Gly Thr 
    130                 135                 140                 


Phe Gln Phe Gln Thr Leu Ile Arg Thr Leu Leu Gln Gly Asp Asn Ser 
145                 150                 155                 160 


Asn Leu Ala Tyr Ser Cys Leu Phe Phe Ile Ser Tyr Gly Phe Gln Ile 
                165                 170                 175     


Leu Ile Leu Ile Phe Ser Ala Phe Ser Glu Asn Asn Glu Ser Ser Asn 
            180                 185                 190         


Asn Pro Ser Ser Ile Ala Ser Phe Leu Ser Ser Ile Thr Tyr Ser Trp 
        195                 200                 205             


Tyr Asp Ser Ile Ile Leu Lys Gly Tyr Lys Arg Pro Leu Thr Leu Glu 
    210                 215                 220                 


Asp Val Trp Glu Val Asp Glu Glu Met Lys Thr Lys Thr Leu Val Ser 
225                 230                 235                 240 


Lys Phe Glu Thr His Met Lys Arg Glu Leu Gln Lys Ala Arg Arg Ala 
                245                 250                 255     


Leu Gln Arg Arg Gln Glu Lys Ser Ser Gln Gln Asn Ser Gly Ala Arg 
            260                 265                 270         


Leu Pro Gly Leu Asn Lys Asn Gln Ser Gln Ser Gln Asp Ala Leu Val 
        275                 280                 285             


Leu Glu Asp Val Glu Lys Lys Lys Lys Lys Ser Gly Thr Lys Lys Asp 
    290                 295                 300                 


Val Pro Lys Ser Trp Leu Met Lys Ala Leu Phe Lys Thr Phe Tyr Met 
305                 310                 315                 320 


Val Leu Leu Lys Ser Phe Leu Leu Lys Leu Val Asn Asp Ile Phe Thr 
                325                 330                 335     


Phe Val Ser Pro Gln Leu Leu Lys Leu Leu Ile Ser Phe Ala Ser Asp 
            340                 345                 350         


Arg Asp Thr Tyr Leu Trp Ile Gly Tyr Leu Cys Ala Ile Leu Leu Phe 
        355                 360                 365             


Thr Ala Ala Leu Ile Gln Ser Phe Cys Leu Gln Cys Tyr Phe Gln Leu 
    370                 375                 380                 


Cys Phe Lys Leu Gly Val Lys Val Arg Thr Ala Ile Met Ala Ser Val 
385                 390                 395                 400 


Tyr Lys Lys Ala Leu Thr Leu Ser Asn Leu Ala Arg Lys Glu Tyr Thr 
                405                 410                 415     


Val Gly Glu Thr Val Asn Leu Met Ser Val Asp Ala Gln Lys Leu Met 
            420                 425                 430         


Asp Val Thr Asn Phe Met His Met Leu Trp Ser Ser Val Leu Gln Ile 
        435                 440                 445             


Val Leu Ser Ile Phe Phe Leu Trp Arg Glu Leu Gly Pro Ser Val Leu 
    450                 455                 460                 


Ala Gly Val Gly Val Met Val Leu Val Ile Pro Ile Asn Ala Ile Leu 
465                 470                 475                 480 


Ser Thr Lys Ser Lys Thr Ile Gln Val Lys Asn Met Lys Asn Lys Asp 
                485                 490                 495     


Lys Arg Leu Lys Ile Met Asn Glu Ile Leu Ser Gly Ile Lys Ile Leu 
            500                 505                 510         


Lys Tyr Phe Ala Trp Glu Pro Ser Phe Arg Asp Gln Val Gln Asn Leu 
        515                 520                 525             


Arg Lys Lys Glu Leu Lys Asn Leu Leu Ala Phe Ser Gln Leu Gln Cys 
    530                 535                 540                 


Val Val Ile Phe Val Phe Gln Leu Thr Pro Val Leu Val Ser Val Val 
545                 550                 555                 560 


Thr Phe Ser Val Tyr Val Leu Val Asp Ser Asn Asn Ile Leu Asp Ala 
                565                 570                 575     


Gln Lys Ala Phe Thr Ser Ile Thr Leu Phe Asn Ile Leu Arg Phe Pro 
            580                 585                 590         


Leu Ser Met Leu Pro Met Met Ile Ser Ser Met Leu Gln Ala Ser Val 
        595                 600                 605             


Ser Thr Glu Arg Leu Glu Lys Tyr Leu Gly Gly Asp Asp Leu Asp Thr 
    610                 615                 620                 


Ser Ala Ile Arg His Asp Cys Asn Phe Asp Lys Ala Met Gln Phe Ser 
625                 630                 635                 640 


Glu Ala Ser Phe Thr Trp Glu His Asp Ser Glu Ala Thr Val Arg Asp 
                645                 650                 655     


Val Asn Leu Asp Ile Met Ala Gly Gln Leu Val Ala Val Ile Gly Pro 
            660                 665                 670         


Val Gly Ser Gly Lys Ser Ser Leu Ile Ser Ala Met Leu Gly Glu Met 
        675                 680                 685             


Glu Asn Val His Gly His Ile Thr Ile Lys Gly Thr Thr Ala Tyr Val 
    690                 695                 700                 


Pro Gln Gln Ser Trp Ile Gln Asn Gly Thr Ile Lys Asp Asn Ile Leu 
705                 710                 715                 720 


Phe Gly Thr Glu Phe Asn Glu Lys Arg Tyr Gln Gln Val Leu Glu Ala 
                725                 730                 735     


Cys Ala Leu Leu Pro Asp Leu Glu Met Leu Pro Gly Gly Asp Leu Ala 
            740                 745                 750         


Glu Ile Gly Glu Lys Gly Ile Asn Leu Ser Gly Gly Gln Lys Gln Arg 
        755                 760                 765             


Ile Ser Leu Ala Arg Ala Thr Tyr Gln Asn Leu Asp Ile Tyr Leu Leu 
    770                 775                 780                 


Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His Ile Phe 
785                 790                 795                 800 


Asn Lys Val Leu Gly Pro Asn Gly Leu Leu Lys Gly Lys Thr Arg Leu 
                805                 810                 815     


Leu Val Thr His Ser Met His Phe Leu Pro Gln Val Asp Glu Ile Val 
            820                 825                 830         


Val Leu Gly Asn Gly Thr Ile Val Glu Lys Gly Ser Tyr Ser Ala Leu 
        835                 840                 845             


Leu Ala Lys Lys Gly Glu Phe Ala Lys Asn Leu Lys Thr Phe Leu Arg 
    850                 855                 860                 


His Thr Gly Pro Glu Glu Glu Ala Thr Val His Asp Gly Ser Glu Glu 
865                 870                 875                 880 


Glu Asp Asp Asp Tyr Gly Leu Ile Ser Ser Val Glu Glu Ile Pro Glu 
                885                 890                 895     


Asp Ala Ala Ser Ile Thr Met Arg Arg Glu Asn Ser Phe Arg Arg Thr 
            900                 905                 910         


Leu Ser Arg Ser Ser Arg Ser Asn Gly Arg His Leu Lys Ser Leu Arg 
        915                 920                 925             


Asn Ser Leu Lys Thr Arg Asn Val Asn Ser Leu Lys Glu Asp Glu Glu 
    930                 935                 940                 


Leu Val Lys Gly Gln Lys Leu Ile Lys Lys Glu Phe Ile Glu Thr Gly 
945                 950                 955                 960 


Lys Val Lys Phe Ser Ile Tyr Leu Glu Tyr Leu Gln Ala Ile Gly Leu 
                965                 970                 975     


Phe Ser Ile Phe Phe Ile Ile Leu Ala Phe Val Met Asn Ser Val Ala 
            980                 985                 990         


Phe Ile Gly Ser Asn Leu Trp Leu  Ser Ala Trp Thr Ser  Asp Ser Lys 
        995                 1000                 1005             


Ile Phe  Asn Ser Thr Asp Tyr  Pro Ala Ser Gln Arg  Asp Met Arg 
    1010                 1015                 1020             


Val Gly  Val Tyr Gly Ala Leu  Gly Leu Ala Gln Gly  Ile Phe Val 
    1025                 1030                 1035             


Phe Ile  Ala His Phe Trp Ser  Ala Phe Gly Phe Val  His Ala Ser 
    1040                 1045                 1050             


Asn Ile  Leu His Lys Gln Leu  Leu Asn Asn Ile Leu  Arg Ala Pro 
    1055                 1060                 1065             


Met Arg  Phe Phe Asp Thr Thr  Pro Thr Gly Arg Ile  Val Asn Arg 
    1070                 1075                 1080             


Phe Ala  Gly Asp Ile Ser Thr  Val Asp Asp Thr Leu  Pro Gln Ser 
    1085                 1090                 1095             


Leu Arg  Ser Trp Ile Thr Cys  Phe Leu Gly Ile Ile  Ser Thr Leu 
    1100                 1105                 1110             


Val Met  Ile Cys Met Ala Thr  Pro Val Phe Thr Ile  Ile Val Ile 
    1115                 1120                 1125             


Pro Leu  Gly Ile Ile Tyr Val  Ser Val Gln Met Phe  Tyr Val Ser 
    1130                 1135                 1140             


Thr Ser  Arg Gln Leu Arg Arg  Leu Asp Ser Val Thr  Arg Ser Pro 
    1145                 1150                 1155             


Ile Tyr  Ser His Phe Ser Glu  Thr Val Ser Gly Leu  Pro Val Ile 
    1160                 1165                 1170             


Arg Ala  Phe Glu His Gln Gln  Arg Phe Leu Lys His  Asn Glu Val 
    1175                 1180                 1185             


Arg Ile  Asp Thr Asn Gln Lys  Cys Val Phe Ser Trp  Ile Thr Ser 
    1190                 1195                 1200             


Asn Arg  Trp Leu Ala Ile Arg  Leu Glu Leu Val Gly  Asn Leu Thr 
    1205                 1210                 1215             


Val Phe  Phe Ser Ala Leu Met  Met Val Ile Tyr Arg  Asp Thr Leu 
    1220                 1225                 1230             


Ser Gly  Asp Thr Val Gly Phe  Val Leu Ser Asn Ala  Leu Asn Ile 
    1235                 1240                 1245             


Thr Gln  Thr Leu Asn Trp Leu  Val Arg Met Thr Ser  Glu Ile Glu 
    1250                 1255                 1260             


Thr Asn  Ile Val Ala Val Glu  Arg Ile Thr Glu Tyr  Thr Lys Val 
    1265                 1270                 1275             


Glu Asn  Glu Ala Pro Trp Val  Thr Asp Lys Arg Pro  Pro Pro Asp 
    1280                 1285                 1290             


Trp Pro  Ser Lys Gly Lys Ile  Gln Phe Asn Asn Tyr  Gln Val Arg 
    1295                 1300                 1305             


Tyr Arg  Pro Glu Leu Asp Leu  Val Leu Arg Gly Ile  Thr Cys Asp 
    1310                 1315                 1320             


Ile Gly  Ser Met Glu Lys Ile  Gly Val Val Gly Arg  Thr Gly Ala 
    1325                 1330                 1335             


Gly Lys  Ser Ser Leu Thr Asn  Cys Leu Phe Arg Ile  Leu Glu Ala 
    1340                 1345                 1350             


Ala Gly  Gly Gln Ile Ile Ile  Asp Gly Val Asp Ile  Ala Ser Ile 
    1355                 1360                 1365             


Gly Leu  His Asp Leu Arg Glu  Lys Leu Thr Ile Ile  Pro Gln Asp 
    1370                 1375                 1380             


Pro Ile  Leu Phe Ser Gly Ser  Leu Arg Met Asn Leu  Asp Pro Phe 
    1385                 1390                 1395             


Asn Asn  Tyr Ser Asp Glu Glu  Ile Trp Lys Ala Leu  Glu Leu Ala 
    1400                 1405                 1410             


His Leu  Lys Ser Phe Val Ala  Ser Leu Gln Leu Gly  Leu Ser His 
    1415                 1420                 1425             


Glu Val  Thr Glu Ala Gly Gly  Asn Leu Ser Ile Gly  Gln Arg Gln 
    1430                 1435                 1440             


Leu Leu  Cys Leu Gly Arg Ala  Leu Leu Arg Lys Ser  Lys Ile Leu 
    1445                 1450                 1455             


Val Leu  Asp Glu Ala Thr Ala  Ala Val Asp Leu Glu  Thr Asp Asn 
    1460                 1465                 1470             


Leu Ile  Gln Thr Thr Ile Gln  Asn Glu Phe Ala His  Cys Thr Val 
    1475                 1480                 1485             


Ile Thr  Ile Ala His Arg Leu  His Thr Ile Met Asp  Ser Asp Lys 
    1490                 1495                 1500             


Val Met  Val Leu Asp Asn Gly  Lys Ile Ile Glu Cys  Gly Ser Pro 
    1505                 1510                 1515             


Glu Glu  Leu Leu Gln Ile Pro  Gly Pro Phe Tyr Phe  Met Ala Lys 
    1520                 1525                 1530             


Glu Ala  Gly Ile Glu Asn Val  Asn Ser Thr Lys Phe  
    1535                 1540                 1545 


<210>  121
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Solute carrier organic anion transporter fam. mem. 2B1 UniProt 
       record number: O94956

<400>  121

Met Gly Pro Arg Ile Gly Pro Ala Gly Glu Val Pro Gln Val Pro Asp 
1               5                   10                  15      


Lys Glu Thr Lys Ala Thr Met Gly Thr Glu Asn Thr Pro Gly Gly Lys 
            20                  25                  30          


Ala Ser Pro Asp Pro Gln Asp Val Arg Pro Ser Val Phe His Asn Ile 
        35                  40                  45              


Lys Leu Phe Val Leu Cys His Ser Leu Leu Gln Leu Ala Gln Leu Met 
    50                  55                  60                  


Ile Ser Gly Tyr Leu Lys Ser Ser Ile Ser Thr Val Glu Lys Arg Phe 
65                  70                  75                  80  


Gly Leu Ser Ser Gln Thr Ser Gly Leu Leu Ala Ser Phe Asn Glu Val 
                85                  90                  95      


Gly Asn Thr Ala Leu Ile Val Phe Val Ser Tyr Phe Gly Ser Arg Val 
            100                 105                 110         


His Arg Pro Arg Met Ile Gly Tyr Gly Ala Ile Leu Val Ala Leu Ala 
        115                 120                 125             


Gly Leu Leu Met Thr Leu Pro His Phe Ile Ser Glu Pro Tyr Arg Tyr 
    130                 135                 140                 


Asp Asn Thr Ser Pro Glu Asp Met Pro Gln Asp Phe Lys Ala Ser Leu 
145                 150                 155                 160 


Cys Leu Pro Thr Thr Ser Ala Pro Ala Ser Ala Pro Ser Asn Gly Asn 
                165                 170                 175     


Cys Ser Ser Tyr Thr Glu Thr Gln His Leu Ser Val Val Gly Ile Met 
            180                 185                 190         


Phe Val Ala Gln Thr Leu Leu Gly Val Gly Gly Val Pro Ile Gln Pro 
        195                 200                 205             


Phe Gly Ile Ser Tyr Ile Asp Asp Phe Ala His Asn Ser Asn Ser Pro 
    210                 215                 220                 


Leu Tyr Leu Gly Ile Leu Phe Ala Val Thr Met Met Gly Pro Gly Leu 
225                 230                 235                 240 


Ala Phe Gly Leu Gly Ser Leu Met Leu Arg Leu Tyr Val Asp Ile Asn 
                245                 250                 255     


Gln Met Pro Glu Gly Gly Ile Ser Leu Thr Ile Lys Asp Pro Arg Trp 
            260                 265                 270         


Val Gly Ala Trp Trp Leu Gly Phe Leu Ile Ala Ala Gly Ala Val Ala 
        275                 280                 285             


Leu Ala Ala Ile Pro Tyr Phe Phe Phe Pro Lys Glu Met Pro Lys Glu 
    290                 295                 300                 


Lys Arg Glu Leu Gln Phe Arg Arg Lys Val Leu Ala Val Thr Asp Ser 
305                 310                 315                 320 


Pro Ala Arg Lys Gly Lys Asp Ser Pro Ser Lys Gln Ser Pro Gly Glu 
                325                 330                 335     


Ser Thr Lys Lys Gln Asp Gly Leu Val Gln Ile Ala Pro Asn Leu Thr 
            340                 345                 350         


Val Ile Gln Phe Ile Lys Val Phe Pro Arg Val Leu Leu Gln Thr Leu 
        355                 360                 365             


Arg His Pro Ile Phe Leu Leu Val Val Leu Ser Gln Val Cys Leu Ser 
    370                 375                 380                 


Ser Met Ala Ala Gly Met Ala Ile Phe Leu Pro Lys Phe Leu Glu Arg 
385                 390                 395                 400 


Gln Phe Ser Ile Thr Ala Ser Tyr Ala Asn Leu Leu Ile Gly Cys Leu 
                405                 410                 415     


Ser Phe Pro Ser Val Ile Val Gly Ile Val Val Gly Gly Val Leu Val 
            420                 425                 430         


Lys Arg Leu His Leu Gly Pro Val Gly Cys Gly Ala Leu Cys Leu Leu 
        435                 440                 445             


Gly Met Leu Leu Cys Leu Phe Phe Ser Leu Pro Leu Phe Phe Ile Gly 
    450                 455                 460                 


Cys Ser Ser His Gln Ile Ala Gly Ile Thr His Gln Thr Ser Ala His 
465                 470                 475                 480 


Pro Gly Leu Glu Leu Ser Pro Ser Cys Met Glu Ala Cys Ser Cys Pro 
                485                 490                 495     


Leu Asp Gly Phe Asn Pro Val Cys Asp Pro Ser Thr Arg Val Glu Tyr 
            500                 505                 510         


Ile Thr Pro Cys His Ala Gly Cys Ser Ser Trp Val Val Gln Asp Ala 
        515                 520                 525             


Leu Asp Asn Ser Gln Val Phe Tyr Thr Asn Cys Ser Cys Val Val Glu 
    530                 535                 540                 


Gly Asn Pro Val Leu Ala Gly Ser Cys Asp Ser Thr Cys Ser His Leu 
545                 550                 555                 560 


Val Val Pro Phe Leu Leu Leu Val Ser Leu Gly Ser Ala Leu Ala Cys 
                565                 570                 575     


Leu Thr His Thr Pro Ser Phe Met Leu Ile Leu Arg Gly Val Lys Lys 
            580                 585                 590         


Glu Asp Lys Thr Leu Ala Val Gly Ile Gln Phe Met Phe Leu Arg Ile 
        595                 600                 605             


Leu Ala Trp Met Pro Ser Pro Val Ile His Gly Ser Ala Ile Asp Thr 
    610                 615                 620                 


Thr Cys Val His Trp Ala Leu Ser Cys Gly Arg Arg Ala Val Cys Arg 
625                 630                 635                 640 


Tyr Tyr Asn Asn Asp Leu Leu Arg Asn Arg Phe Ile Gly Leu Gln Phe 
                645                 650                 655     


Phe Phe Lys Thr Gly Ser Val Ile Cys Phe Ala Leu Val Leu Ala Val 
            660                 665                 670         


Leu Arg Gln Gln Asp Lys Glu Ala Arg Thr Lys Glu Ser Arg Ser Ser 
        675                 680                 685             


Pro Ala Val Glu Gln Gln Leu Leu Val Ser Gly Pro Gly Lys Lys Pro 
    690                 695                 700                 


Glu Asp Ser Arg Val 
705                 


<210>  122
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Solute carrier family 7, number 7 or Y+L amino acid transporter 1
       UniProt record number: Q9UM01

<400>  122

Met Val Asp Ser Thr Glu Tyr Glu Val Ala Ser Gln Pro Glu Val Glu 
1               5                   10                  15      


Thr Ser Pro Leu Gly Asp Gly Ala Ser Pro Gly Pro Glu Gln Val Lys 
            20                  25                  30          


Leu Lys Lys Glu Ile Ser Leu Leu Asn Gly Val Cys Leu Ile Val Gly 
        35                  40                  45              


Asn Met Ile Gly Ser Gly Ile Phe Val Ser Pro Lys Gly Val Leu Ile 
    50                  55                  60                  


Tyr Ser Ala Ser Phe Gly Leu Ser Leu Val Ile Trp Ala Val Gly Gly 
65                  70                  75                  80  


Leu Phe Ser Val Phe Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr 
                85                  90                  95      


Ile Lys Lys Ser Gly Ala Ser Tyr Ala Tyr Ile Leu Glu Ala Phe Gly 
            100                 105                 110         


Gly Phe Leu Ala Phe Ile Arg Leu Trp Thr Ser Leu Leu Ile Ile Glu 
        115                 120                 125             


Pro Thr Ser Gln Ala Ile Ile Ala Ile Thr Phe Ala Asn Tyr Met Val 
    130                 135                 140                 


Gln Pro Leu Phe Pro Ser Cys Phe Ala Pro Tyr Ala Ala Ser Arg Leu 
145                 150                 155                 160 


Leu Ala Ala Ala Cys Ile Cys Leu Leu Thr Phe Ile Asn Cys Ala Tyr 
                165                 170                 175     


Val Lys Trp Gly Thr Leu Val Gln Asp Ile Phe Thr Tyr Ala Lys Val 
            180                 185                 190         


Leu Ala Leu Ile Ala Val Ile Val Ala Gly Ile Val Arg Leu Gly Gln 
        195                 200                 205             


Gly Ala Ser Thr His Phe Glu Asn Ser Phe Glu Gly Ser Ser Phe Ala 
    210                 215                 220                 


Val Gly Asp Ile Ala Leu Ala Leu Tyr Ser Ala Leu Phe Ser Tyr Ser 
225                 230                 235                 240 


Gly Trp Asp Thr Leu Asn Tyr Val Thr Glu Glu Ile Lys Asn Pro Glu 
                245                 250                 255     


Arg Asn Leu Pro Leu Ser Ile Gly Ile Ser Met Pro Ile Val Thr Ile 
            260                 265                 270         


Ile Tyr Ile Leu Thr Asn Val Ala Tyr Tyr Thr Val Leu Asp Met Arg 
        275                 280                 285             


Asp Ile Leu Ala Ser Asp Ala Val Ala Val Thr Phe Ala Asp Gln Ile 
    290                 295                 300                 


Phe Gly Ile Phe Asn Trp Ile Ile Pro Leu Ser Val Ala Leu Ser Cys 
305                 310                 315                 320 


Phe Gly Gly Leu Asn Ala Ser Ile Val Ala Ala Ser Arg Leu Phe Phe 
                325                 330                 335     


Val Gly Ser Arg Glu Gly His Leu Pro Asp Ala Ile Cys Met Ile His 
            340                 345                 350         


Val Glu Arg Phe Thr Pro Val Pro Ser Leu Leu Phe Asn Gly Ile Met 
        355                 360                 365             


Ala Leu Ile Tyr Leu Cys Val Glu Asp Ile Phe Gln Leu Ile Asn Tyr 
    370                 375                 380                 


Tyr Ser Phe Ser Tyr Trp Phe Phe Val Gly Leu Ser Ile Val Gly Gln 
385                 390                 395                 400 


Leu Tyr Leu Arg Trp Lys Glu Pro Asp Arg Pro Arg Pro Leu Lys Leu 
                405                 410                 415     


Ser Val Phe Phe Pro Ile Val Phe Cys Leu Cys Thr Ile Phe Leu Val 
            420                 425                 430         


Ala Val Pro Leu Tyr Ser Asp Thr Ile Asn Ser Leu Ile Gly Ile Ala 
        435                 440                 445             


Ile Ala Leu Ser Gly Leu Pro Phe Tyr Phe Leu Ile Ile Arg Val Pro 
    450                 455                 460                 


Glu His Lys Arg Pro Leu Tyr Leu Arg Arg Ile Val Gly Ser Ala Thr 
465                 470                 475                 480 


Arg Tyr Leu Gln Val Leu Cys Met Ser Val Ala Ala Glu Met Asp Leu 
                485                 490                 495     


Glu Asp Gly Gly Glu Met Pro Lys Gln Arg Asp Pro Lys Ser Asn 
            500                 505                 510     


<210>  123
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Solute carrier family 22 member 3 UniProt record number: O75751

<400>  123

Met Pro Ser Phe Asp Glu Ala Leu Gln Arg Val Gly Glu Phe Gly Arg 
1               5                   10                  15      


Phe Gln Arg Arg Val Phe Leu Leu Leu Cys Leu Thr Gly Val Thr Phe 
            20                  25                  30          


Ala Phe Leu Phe Val Gly Val Val Phe Leu Gly Thr Gln Pro Asp His 
        35                  40                  45              


Tyr Trp Cys Arg Gly Pro Ser Ala Ala Ala Leu Ala Glu Arg Cys Gly 
    50                  55                  60                  


Trp Ser Pro Glu Glu Glu Trp Asn Arg Thr Ala Pro Ala Ser Arg Gly 
65                  70                  75                  80  


Pro Glu Pro Pro Glu Arg Arg Gly Arg Cys Gln Arg Tyr Leu Leu Glu 
                85                  90                  95      


Ala Ala Asn Asp Ser Ala Ser Ala Thr Ser Ala Leu Ser Cys Ala Asp 
            100                 105                 110         


Pro Leu Ala Ala Phe Pro Asn Arg Ser Ala Pro Leu Val Pro Cys Arg 
        115                 120                 125             


Gly Gly Trp Arg Tyr Ala Gln Ala His Ser Thr Ile Val Ser Glu Phe 
    130                 135                 140                 


Asp Leu Val Cys Val Asn Ala Trp Met Leu Asp Leu Thr Gln Ala Ile 
145                 150                 155                 160 


Leu Asn Leu Gly Phe Leu Thr Gly Ala Phe Thr Leu Gly Tyr Ala Ala 
                165                 170                 175     


Asp Arg Tyr Gly Arg Ile Val Ile Tyr Leu Leu Ser Cys Leu Gly Val 
            180                 185                 190         


Gly Val Thr Gly Val Val Val Ala Phe Ala Pro Asn Phe Pro Val Phe 
        195                 200                 205             


Val Ile Phe Arg Phe Leu Gln Gly Val Phe Gly Lys Gly Thr Trp Met 
    210                 215                 220                 


Thr Cys Tyr Val Ile Val Thr Glu Ile Val Gly Ser Lys Gln Arg Arg 
225                 230                 235                 240 


Ile Val Gly Ile Val Ile Gln Met Phe Phe Thr Leu Gly Ile Ile Ile 
                245                 250                 255     


Leu Pro Gly Ile Ala Tyr Phe Ile Pro Asn Trp Gln Gly Ile Gln Leu 
            260                 265                 270         


Ala Ile Thr Leu Pro Ser Phe Leu Phe Leu Leu Tyr Tyr Trp Val Val 
        275                 280                 285             


Pro Glu Ser Pro Arg Trp Leu Ile Thr Arg Lys Lys Gly Asp Lys Ala 
    290                 295                 300                 


Leu Gln Ile Leu Arg Arg Ile Ala Lys Cys Asn Gly Lys Tyr Leu Ser 
305                 310                 315                 320 


Ser Asn Tyr Ser Glu Ile Thr Val Thr Asp Glu Glu Val Ser Asn Pro 
                325                 330                 335     


Ser Phe Leu Asp Leu Val Arg Thr Pro Gln Met Arg Lys Cys Thr Leu 
            340                 345                 350         


Ile Leu Met Phe Ala Trp Phe Thr Ser Ala Val Val Tyr Gln Gly Leu 
        355                 360                 365             


Val Met Arg Leu Gly Ile Ile Gly Gly Asn Leu Tyr Ile Asp Phe Phe 
    370                 375                 380                 


Ile Ser Gly Val Val Glu Leu Pro Gly Ala Leu Leu Ile Leu Leu Thr 
385                 390                 395                 400 


Ile Glu Arg Leu Gly Arg Arg Leu Pro Phe Ala Ala Ser Asn Ile Val 
                405                 410                 415     


Ala Gly Val Ala Cys Leu Val Thr Ala Phe Leu Pro Glu Gly Ile Ala 
            420                 425                 430         


Trp Leu Arg Thr Thr Val Ala Thr Leu Gly Arg Leu Gly Ile Thr Met 
        435                 440                 445             


Ala Phe Glu Ile Val Tyr Leu Val Asn Ser Glu Leu Tyr Pro Thr Thr 
    450                 455                 460                 


Leu Arg Asn Phe Gly Val Ser Leu Cys Ser Gly Leu Cys Asp Phe Gly 
465                 470                 475                 480 


Gly Ile Ile Ala Pro Phe Leu Leu Phe Arg Leu Ala Ala Val Trp Leu 
                485                 490                 495     


Glu Leu Pro Leu Ile Ile Phe Gly Ile Leu Ala Ser Ile Cys Gly Gly 
            500                 505                 510         


Leu Val Met Leu Leu Pro Glu Thr Lys Gly Ile Ala Leu Pro Glu Thr 
        515                 520                 525             


Val Asp Asp Val Glu Lys Leu Gly Ser Pro His Ser Cys Lys Cys Gly 
    530                 535                 540                 


Arg Asn Lys Lys Thr Pro Val Ser Arg Ser His Leu 
545                 550                 555     


<210>  124
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Solute carrier organic anion transporter fam. mem. 2A1 UniProt 
       record number: Q92959

<400>  124

Met Gly Leu Leu Pro Lys Leu Gly Ala Ser Gln Gly Ser Asp Thr Ser 
1               5                   10                  15      


Thr Ser Arg Ala Gly Arg Cys Ala Arg Ser Val Phe Gly Asn Ile Lys 
            20                  25                  30          


Val Phe Val Leu Cys Gln Gly Leu Leu Gln Leu Cys Gln Leu Leu Tyr 
        35                  40                  45              


Ser Ala Tyr Phe Lys Ser Ser Leu Thr Thr Ile Glu Lys Arg Phe Gly 
    50                  55                  60                  


Leu Ser Ser Ser Ser Ser Gly Leu Ile Ser Ser Leu Asn Glu Ile Ser 
65                  70                  75                  80  


Asn Ala Ile Leu Ile Ile Phe Val Ser Tyr Phe Gly Ser Arg Val His 
                85                  90                  95      


Arg Pro Arg Leu Ile Gly Ile Gly Gly Leu Phe Leu Ala Ala Gly Ala 
            100                 105                 110         


Phe Ile Leu Thr Leu Pro His Phe Leu Ser Glu Pro Tyr Gln Tyr Thr 
        115                 120                 125             


Leu Ala Ser Thr Gly Asn Asn Ser Arg Leu Gln Ala Glu Leu Cys Gln 
    130                 135                 140                 


Lys His Trp Gln Asp Leu Pro Pro Ser Lys Cys His Ser Thr Thr Gln 
145                 150                 155                 160 


Asn Pro Gln Lys Glu Thr Ser Ser Met Trp Gly Leu Met Val Val Ala 
                165                 170                 175     


Gln Leu Leu Ala Gly Ile Gly Thr Val Pro Ile Gln Pro Phe Gly Ile 
            180                 185                 190         


Ser Tyr Val Asp Asp Phe Ser Glu Pro Ser Asn Ser Pro Leu Tyr Ile 
        195                 200                 205             


Ser Ile Leu Phe Ala Ile Ser Val Phe Gly Pro Ala Phe Gly Tyr Leu 
    210                 215                 220                 


Leu Gly Ser Val Met Leu Gln Ile Phe Val Asp Tyr Gly Arg Val Asn 
225                 230                 235                 240 


Thr Ala Ala Val Asn Leu Val Pro Gly Asp Pro Arg Trp Ile Gly Ala 
                245                 250                 255     


Trp Trp Leu Gly Leu Leu Ile Ser Ser Ala Leu Leu Val Leu Thr Ser 
            260                 265                 270         


Phe Pro Phe Phe Phe Phe Pro Arg Ala Met Pro Ile Gly Ala Lys Arg 
        275                 280                 285             


Ala Pro Ala Thr Ala Asp Glu Ala Arg Lys Leu Glu Glu Ala Lys Ser 
    290                 295                 300                 


Arg Gly Ser Leu Val Asp Phe Ile Lys Arg Phe Pro Cys Ile Phe Leu 
305                 310                 315                 320 


Arg Leu Leu Met Asn Ser Leu Phe Val Leu Val Val Leu Ala Gln Cys 
                325                 330                 335     


Thr Phe Ser Ser Val Ile Ala Gly Leu Ser Thr Phe Leu Asn Lys Phe 
            340                 345                 350         


Leu Glu Lys Gln Tyr Gly Thr Ser Ala Ala Tyr Ala Asn Phe Leu Ile 
        355                 360                 365             


Gly Ala Val Asn Leu Pro Ala Ala Ala Leu Gly Met Leu Phe Gly Gly 
    370                 375                 380                 


Ile Leu Met Lys Arg Phe Val Phe Ser Leu Gln Ala Ile Pro Arg Ile 
385                 390                 395                 400 


Ala Thr Thr Ile Ile Thr Ile Ser Met Ile Leu Cys Val Pro Leu Phe 
                405                 410                 415     


Phe Met Gly Cys Ser Thr Pro Thr Val Ala Glu Val Tyr Pro Pro Ser 
            420                 425                 430         


Thr Ser Ser Ser Ile His Pro Gln Ser Pro Ala Cys Arg Arg Asp Cys 
        435                 440                 445             


Ser Cys Pro Asp Ser Ile Phe His Pro Val Cys Gly Asp Asn Gly Ile 
    450                 455                 460                 


Glu Tyr Leu Ser Pro Cys His Ala Gly Cys Ser Asn Ile Asn Met Ser 
465                 470                 475                 480 


Ser Ala Thr Ser Lys Gln Leu Ile Tyr Leu Asn Cys Ser Cys Val Thr 
                485                 490                 495     


Gly Gly Ser Ala Ser Ala Lys Thr Gly Ser Cys Pro Val Pro Cys Ala 
            500                 505                 510         


His Phe Leu Leu Pro Ala Ile Phe Leu Ile Ser Phe Val Ser Leu Ile 
        515                 520                 525             


Ala Cys Ile Ser His Asn Pro Leu Tyr Met Met Val Leu Arg Val Val 
    530                 535                 540                 


Asn Gln Glu Glu Lys Ser Phe Ala Ile Gly Val Gln Phe Leu Leu Met 
545                 550                 555                 560 


Arg Leu Leu Ala Trp Leu Pro Ser Pro Ala Leu Tyr Gly Leu Thr Ile 
                565                 570                 575     


Asp His Ser Cys Ile Arg Trp Asn Ser Leu Cys Leu Gly Arg Arg Gly 
            580                 585                 590         


Ala Cys Ala Tyr Tyr Asp Asn Asp Ala Leu Arg Asp Arg Tyr Leu Gly 
        595                 600                 605             


Leu Gln Met Gly Tyr Lys Ala Leu Gly Met Leu Leu Leu Cys Phe Ile 
    610                 615                 620                 


Ser Trp Arg Val Lys Lys Asn Lys Glu Tyr Asn Val Gln Lys Ala Ala 
625                 630                 635                 640 


Gly Leu Ile 
            


<210>  125
<211>  1359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP-binding cassette sub-family C (MRP) member 12 or Multidrug 
       resistance-associated protein 9 UniProt record number: Q96J65

<400>  125

Met Val Gly Glu Gly Pro Tyr Leu Ile Ser Asp Leu Asp Gln Arg Gly 
1               5                   10                  15      


Arg Arg Arg Ser Phe Ala Glu Arg Tyr Asp Pro Ser Leu Lys Thr Met 
            20                  25                  30          


Ile Pro Val Arg Pro Cys Ala Arg Leu Ala Pro Asn Pro Val Asp Asp 
        35                  40                  45              


Ala Gly Leu Leu Ser Phe Ala Thr Phe Ser Trp Leu Thr Pro Val Met 
    50                  55                  60                  


Val Lys Gly Tyr Arg Gln Arg Leu Thr Val Asp Thr Leu Pro Pro Leu 
65                  70                  75                  80  


Ser Thr Tyr Asp Ser Ser Asp Thr Asn Ala Lys Arg Phe Arg Val Leu 
                85                  90                  95      


Trp Asp Glu Glu Val Ala Arg Val Gly Pro Glu Lys Ala Ser Leu Ser 
            100                 105                 110         


His Val Val Trp Lys Phe Gln Arg Thr Arg Val Leu Met Asp Ile Val 
        115                 120                 125             


Ala Asn Ile Leu Cys Ile Ile Met Ala Ala Ile Gly Pro Val Ile Leu 
    130                 135                 140                 


Ile His Gln Ile Leu Gln Gln Thr Glu Arg Thr Ser Gly Lys Val Trp 
145                 150                 155                 160 


Val Gly Ile Gly Leu Cys Ile Ala Leu Phe Ala Thr Glu Phe Thr Lys 
                165                 170                 175     


Val Phe Phe Trp Ala Leu Ala Trp Ala Ile Asn Tyr Arg Thr Ala Ile 
            180                 185                 190         


Arg Leu Lys Val Ala Leu Ser Thr Leu Val Phe Glu Asn Leu Val Ser 
        195                 200                 205             


Phe Lys Thr Leu Thr His Ile Ser Val Gly Glu Val Leu Asn Ile Leu 
    210                 215                 220                 


Ser Ser Asp Ser Tyr Ser Leu Phe Glu Ala Ala Leu Phe Cys Pro Leu 
225                 230                 235                 240 


Pro Ala Thr Ile Pro Ile Leu Met Val Phe Cys Ala Ala Tyr Ala Phe 
                245                 250                 255     


Phe Ile Leu Gly Pro Thr Ala Leu Ile Gly Ile Ser Val Tyr Val Ile 
            260                 265                 270         


Phe Ile Pro Val Gln Met Phe Met Ala Lys Leu Asn Ser Ala Phe Arg 
        275                 280                 285             


Arg Ser Ala Ile Leu Val Thr Asp Lys Arg Val Gln Thr Met Asn Glu 
    290                 295                 300                 


Phe Leu Thr Cys Ile Arg Leu Ile Lys Met Tyr Ala Trp Glu Lys Ser 
305                 310                 315                 320 


Phe Thr Asn Thr Ile Gln Asp Ile Arg Arg Arg Glu Arg Lys Leu Leu 
                325                 330                 335     


Glu Lys Ala Gly Phe Val Gln Ser Gly Asn Ser Ala Leu Ala Pro Ile 
            340                 345                 350         


Val Ser Thr Ile Ala Ile Val Leu Thr Leu Ser Cys His Ile Leu Leu 
        355                 360                 365             


Arg Arg Lys Leu Thr Ala Pro Val Ala Phe Ser Val Ile Ala Met Phe 
    370                 375                 380                 


Asn Val Met Lys Phe Ser Ile Ala Ile Leu Pro Phe Ser Ile Lys Ala 
385                 390                 395                 400 


Met Ala Glu Ala Asn Val Ser Leu Arg Arg Met Lys Lys Ile Leu Ile 
                405                 410                 415     


Asp Lys Ser Pro Pro Ser Tyr Ile Thr Gln Pro Glu Asp Pro Asp Thr 
            420                 425                 430         


Val Leu Leu Leu Ala Asn Ala Thr Leu Thr Trp Glu His Glu Ala Ser 
        435                 440                 445             


Arg Lys Ser Thr Pro Lys Lys Leu Gln Asn Gln Lys Arg His Leu Cys 
    450                 455                 460                 


Lys Lys Gln Arg Ser Glu Ala Tyr Ser Glu Arg Ser Pro Pro Ala Lys 
465                 470                 475                 480 


Gly Ala Thr Gly Pro Glu Glu Gln Ser Asp Ser Leu Lys Ser Val Leu 
                485                 490                 495     


His Ser Ile Ser Phe Val Val Arg Lys Gly Lys Ile Leu Gly Ile Cys 
            500                 505                 510         


Gly Asn Val Gly Ser Gly Lys Ser Ser Leu Leu Ala Ala Leu Leu Gly 
        515                 520                 525             


Gln Met Gln Leu Gln Lys Gly Val Val Ala Val Asn Gly Thr Leu Ala 
    530                 535                 540                 


Tyr Val Ser Gln Gln Ala Trp Ile Phe His Gly Asn Val Arg Glu Asn 
545                 550                 555                 560 


Ile Leu Phe Gly Glu Lys Tyr Asp His Gln Arg Tyr Gln His Thr Val 
                565                 570                 575     


Arg Val Cys Gly Leu Gln Lys Asp Leu Ser Asn Leu Pro Tyr Gly Asp 
            580                 585                 590         


Leu Thr Glu Ile Gly Glu Arg Gly Leu Asn Leu Ser Gly Gly Gln Arg 
        595                 600                 605             


Gln Arg Ile Ser Leu Ala Arg Ala Val Tyr Ser Asp Arg Gln Leu Tyr 
    610                 615                 620                 


Leu Leu Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His 
625                 630                 635                 640 


Val Phe Glu Glu Cys Ile Lys Lys Thr Leu Arg Gly Lys Thr Val Val 
                645                 650                 655     


Leu Val Thr His Gln Leu Gln Phe Leu Glu Ser Cys Asp Glu Val Ile 
            660                 665                 670         


Leu Leu Glu Asp Gly Glu Ile Cys Glu Lys Gly Thr His Lys Glu Leu 
        675                 680                 685             


Met Glu Glu Arg Gly Arg Tyr Ala Lys Leu Ile His Asn Leu Arg Gly 
    690                 695                 700                 


Leu Gln Phe Lys Asp Pro Glu His Leu Tyr Asn Ala Ala Met Val Glu 
705                 710                 715                 720 


Ala Phe Lys Glu Ser Pro Ala Glu Arg Glu Glu Asp Ala Gly Ile Ile 
                725                 730                 735     


Val Leu Ala Pro Gly Asn Glu Lys Asp Glu Gly Lys Glu Ser Glu Thr 
            740                 745                 750         


Gly Ser Glu Phe Val Asp Thr Lys Val Pro Glu His Gln Leu Ile Gln 
        755                 760                 765             


Thr Glu Ser Pro Gln Glu Gly Thr Val Thr Trp Lys Thr Tyr His Thr 
    770                 775                 780                 


Tyr Ile Lys Ala Ser Gly Gly Tyr Leu Leu Ser Leu Phe Thr Val Phe 
785                 790                 795                 800 


Leu Phe Leu Leu Met Ile Gly Ser Ala Ala Phe Ser Asn Trp Trp Leu 
                805                 810                 815     


Gly Leu Trp Leu Asp Lys Gly Ser Arg Met Thr Cys Gly Pro Gln Gly 
            820                 825                 830         


Asn Arg Thr Met Cys Glu Val Gly Ala Val Leu Ala Asp Ile Gly Gln 
        835                 840                 845             


His Val Tyr Gln Trp Val Tyr Thr Ala Ser Met Val Phe Met Leu Val 
    850                 855                 860                 


Phe Gly Val Thr Lys Gly Phe Val Phe Thr Lys Thr Thr Leu Met Ala 
865                 870                 875                 880 


Ser Ser Ser Leu His Asp Thr Val Phe Asp Lys Ile Leu Lys Ser Pro 
                885                 890                 895     


Met Ser Phe Phe Asp Thr Thr Pro Thr Gly Arg Leu Met Asn Arg Phe 
            900                 905                 910         


Ser Lys Asp Met Asp Glu Leu Asp Val Arg Leu Pro Phe His Ala Glu 
        915                 920                 925             


Asn Phe Leu Gln Gln Phe Phe Met Val Val Phe Ile Leu Val Ile Leu 
    930                 935                 940                 


Ala Ala Val Phe Pro Ala Val Leu Leu Val Val Ala Ser Leu Ala Val 
945                 950                 955                 960 


Gly Phe Phe Ile Leu Leu Arg Ile Phe His Arg Gly Val Gln Glu Leu 
                965                 970                 975     


Lys Lys Val Glu Asn Val Ser Arg Ser Pro Trp Phe Thr His Ile Thr 
            980                 985                 990         


Ser Ser Met Gln Gly Leu Gly Ile  Ile His Ala Tyr Gly  Lys Lys Glu 
        995                 1000                 1005             


Ser Cys  Ile Thr Tyr His Leu  Leu Tyr Phe Asn Cys  Ala Leu Arg 
    1010                 1015                 1020             


Trp Phe  Ala Leu Arg Met Asp  Val Leu Met Asn Ile  Leu Thr Phe 
    1025                 1030                 1035             


Thr Val  Ala Leu Leu Val Thr  Leu Ser Phe Ser Ser  Ile Ser Thr 
    1040                 1045                 1050             


Ser Ser  Lys Gly Leu Ser Leu  Ser Tyr Ile Ile Gln  Leu Ser Gly 
    1055                 1060                 1065             


Leu Leu  Gln Val Cys Val Arg  Thr Gly Thr Glu Thr  Gln Ala Lys 
    1070                 1075                 1080             


Phe Thr  Ser Val Glu Leu Leu  Arg Glu Tyr Ile Ser  Thr Cys Val 
    1085                 1090                 1095             


Pro Glu  Cys Thr His Pro Leu  Lys Val Gly Thr Cys  Pro Lys Asp 
    1100                 1105                 1110             


Trp Pro  Ser Arg Gly Glu Ile  Thr Phe Arg Asp Tyr  Gln Met Arg 
    1115                 1120                 1125             


Tyr Arg  Asp Asn Thr Pro Leu  Val Leu Asp Ser Leu  Asn Leu Asn 
    1130                 1135                 1140             


Ile Gln  Ser Gly Gln Thr Val  Gly Ile Val Gly Arg  Thr Gly Ser 
    1145                 1150                 1155             


Gly Lys  Ser Ser Leu Gly Met  Ala Leu Phe Arg Leu  Val Glu Pro 
    1160                 1165                 1170             


Ala Ser  Gly Thr Ile Phe Ile  Asp Glu Val Asp Ile  Cys Ile Leu 
    1175                 1180                 1185             


Ser Leu  Glu Asp Leu Arg Thr  Lys Leu Thr Val Ile  Pro Gln Asp 
    1190                 1195                 1200             


Pro Val  Leu Phe Val Gly Thr  Val Arg Tyr Asn Leu  Asp Pro Phe 
    1205                 1210                 1215             


Glu Ser  His Thr Asp Glu Met  Leu Trp Gln Val Leu  Glu Arg Thr 
    1220                 1225                 1230             


Phe Met  Arg Asp Thr Ile Met  Lys Leu Pro Glu Lys  Leu Gln Ala 
    1235                 1240                 1245             


Glu Val  Thr Glu Asn Gly Glu  Asn Phe Ser Val Gly  Glu Arg Gln 
    1250                 1255                 1260             


Leu Leu  Cys Val Ala Arg Ala  Leu Leu Arg Asn Ser  Lys Ile Ile 
    1265                 1270                 1275             


Leu Leu  Asp Glu Ala Thr Ala  Ser Met Asp Ser Lys  Thr Asp Thr 
    1280                 1285                 1290             


Leu Val  Gln Asn Thr Ile Lys  Asp Ala Phe Lys Gly  Cys Thr Val 
    1295                 1300                 1305             


Leu Thr  Ile Ala His Arg Leu  Asn Thr Val Leu Asn  Cys Asp His 
    1310                 1315                 1320             


Val Leu  Val Met Glu Asn Gly  Lys Val Ile Glu Phe  Asp Lys Pro 
    1325                 1330                 1335             


Glu Val  Leu Ala Glu Lys Pro  Asp Ser Ala Phe Ala  Met Leu Leu 
    1340                 1345                 1350             


Ala Ala  Glu Val Arg Leu 
    1355                 


<210>  126
<211>  1500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATPase, Cu++ transporting alpha polypeptide or 
       Copper-transporting ATPase 1 UniProt record number: Q04656

<400>  126

Met Asp Pro Ser Met Gly Val Asn Ser Val Thr Ile Ser Val Glu Gly 
1               5                   10                  15      


Met Thr Cys Asn Ser Cys Val Trp Thr Ile Glu Gln Gln Ile Gly Lys 
            20                  25                  30          


Val Asn Gly Val His His Ile Lys Val Ser Leu Glu Glu Lys Asn Ala 
        35                  40                  45              


Thr Ile Ile Tyr Asp Pro Lys Leu Gln Thr Pro Lys Thr Leu Gln Glu 
    50                  55                  60                  


Ala Ile Asp Asp Met Gly Phe Asp Ala Val Ile His Asn Pro Asp Pro 
65                  70                  75                  80  


Leu Pro Val Leu Thr Asp Thr Leu Phe Leu Thr Val Thr Ala Ser Leu 
                85                  90                  95      


Thr Leu Pro Trp Asp His Ile Gln Ser Thr Leu Leu Lys Thr Lys Gly 
            100                 105                 110         


Val Thr Asp Ile Lys Ile Tyr Pro Gln Lys Arg Thr Val Ala Val Thr 
        115                 120                 125             


Ile Ile Pro Ser Ile Val Asn Ala Asn Gln Ile Lys Glu Leu Val Pro 
    130                 135                 140                 


Glu Leu Ser Leu Asp Thr Gly Thr Leu Glu Lys Lys Ser Gly Ala Cys 
145                 150                 155                 160 


Glu Asp His Ser Met Ala Gln Ala Gly Glu Val Val Leu Lys Met Lys 
                165                 170                 175     


Val Glu Gly Met Thr Cys His Ser Cys Thr Ser Thr Ile Glu Gly Lys 
            180                 185                 190         


Ile Gly Lys Leu Gln Gly Val Gln Arg Ile Lys Val Ser Leu Asp Asn 
        195                 200                 205             


Gln Glu Ala Thr Ile Val Tyr Gln Pro His Leu Ile Ser Val Glu Glu 
    210                 215                 220                 


Met Lys Lys Gln Ile Glu Ala Met Gly Phe Pro Ala Phe Val Lys Lys 
225                 230                 235                 240 


Gln Pro Lys Tyr Leu Lys Leu Gly Ala Ile Asp Val Glu Arg Leu Lys 
                245                 250                 255     


Asn Thr Pro Val Lys Ser Ser Glu Gly Ser Gln Gln Arg Ser Pro Ser 
            260                 265                 270         


Tyr Thr Asn Asp Ser Thr Ala Thr Phe Ile Ile Asp Gly Met His Cys 
        275                 280                 285             


Lys Ser Cys Val Ser Asn Ile Glu Ser Thr Leu Ser Ala Leu Gln Tyr 
    290                 295                 300                 


Val Ser Ser Ile Val Val Ser Leu Glu Asn Arg Ser Ala Ile Val Lys 
305                 310                 315                 320 


Tyr Asn Ala Ser Ser Val Thr Pro Glu Ser Leu Arg Lys Ala Ile Glu 
                325                 330                 335     


Ala Val Ser Pro Gly Leu Tyr Arg Val Ser Ile Thr Ser Glu Val Glu 
            340                 345                 350         


Ser Thr Ser Asn Ser Pro Ser Ser Ser Ser Leu Gln Lys Ile Pro Leu 
        355                 360                 365             


Asn Val Val Ser Gln Pro Leu Thr Gln Glu Thr Val Ile Asn Ile Asp 
    370                 375                 380                 


Gly Met Thr Cys Asn Ser Cys Val Gln Ser Ile Glu Gly Val Ile Ser 
385                 390                 395                 400 


Lys Lys Pro Gly Val Lys Ser Ile Arg Val Ser Leu Ala Asn Ser Asn 
                405                 410                 415     


Gly Thr Val Glu Tyr Asp Pro Leu Leu Thr Ser Pro Glu Thr Leu Arg 
            420                 425                 430         


Gly Ala Ile Glu Asp Met Gly Phe Asp Ala Thr Leu Ser Asp Thr Asn 
        435                 440                 445             


Glu Pro Leu Val Val Ile Ala Gln Pro Ser Ser Glu Met Pro Leu Leu 
    450                 455                 460                 


Thr Ser Thr Asn Glu Phe Tyr Thr Lys Gly Met Thr Pro Val Gln Asp 
465                 470                 475                 480 


Lys Glu Glu Gly Lys Asn Ser Ser Lys Cys Tyr Ile Gln Val Thr Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ala Asn Ile Glu Arg Asn Leu Arg Arg 
            500                 505                 510         


Glu Glu Gly Ile Tyr Ser Ile Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Val Arg Tyr Asn Pro Ala Val Ile Gln Pro Pro Met Ile Ala Glu 
    530                 535                 540                 


Phe Ile Arg Glu Leu Gly Phe Gly Ala Thr Val Ile Glu Asn Ala Asp 
545                 550                 555                 560 


Glu Gly Asp Gly Val Leu Glu Leu Val Val Arg Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Lys Ile Glu Ser Ser Leu Thr Lys His Arg Gly Ile 
            580                 585                 590         


Leu Tyr Cys Ser Val Ala Leu Ala Thr Asn Lys Ala His Ile Lys Tyr 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile His Thr Ile Glu Ser 
    610                 615                 620                 


Leu Gly Phe Glu Ala Ser Leu Val Lys Lys Asp Arg Ser Ala Ser His 
625                 630                 635                 640 


Leu Asp His Lys Arg Glu Ile Arg Gln Trp Arg Arg Ser Phe Leu Val 
                645                 650                 655     


Ser Leu Phe Phe Cys Ile Pro Val Met Gly Leu Met Ile Tyr Met Met 
            660                 665                 670         


Val Met Asp His His Phe Ala Thr Leu His His Asn Gln Asn Met Ser 
        675                 680                 685             


Lys Glu Glu Met Ile Asn Leu His Ser Ser Met Phe Leu Glu Arg Gln 
    690                 695                 700                 


Ile Leu Pro Gly Leu Ser Val Met Asn Leu Leu Ser Phe Leu Leu Cys 
705                 710                 715                 720 


Val Pro Val Gln Phe Phe Gly Gly Trp Tyr Phe Tyr Ile Gln Ala Tyr 
                725                 730                 735     


Lys Ala Leu Lys His Lys Thr Ala Asn Met Asp Val Leu Ile Val Leu 
            740                 745                 750         


Ala Thr Thr Ile Ala Phe Ala Tyr Ser Leu Ile Ile Leu Leu Val Ala 
        755                 760                 765             


Met Tyr Glu Arg Ala Lys Val Asn Pro Ile Thr Phe Phe Asp Thr Pro 
    770                 775                 780                 


Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Ile 
785                 790                 795                 800 


Ala Lys Gly Lys Thr Ser Glu Ala Leu Ala Lys Leu Ile Ser Leu Gln 
                805                 810                 815     


Ala Thr Glu Ala Thr Ile Val Thr Leu Asp Ser Asp Asn Ile Leu Leu 
            820                 825                 830         


Ser Glu Glu Gln Val Asp Val Glu Leu Val Gln Arg Gly Asp Ile Ile 
        835                 840                 845             


Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Arg Val Ile Glu 
    850                 855                 860                 


Gly His Ser Met Val Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro 
865                 870                 875                 880 


Val Ala Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Gln 
                885                 890                 895     


Asn Gly Ser Leu Leu Ile Cys Ala Thr His Val Gly Ala Asp Thr Thr 
            900                 905                 910         


Leu Ser Gln Ile Val Lys Leu Val Glu Glu Ala Gln Thr Ser Lys Ala 
        915                 920                 925             


Pro Ile Gln Gln Phe Ala Asp Lys Leu Ser Gly Tyr Phe Val Pro Phe 
    930                 935                 940                 


Ile Val Phe Val Ser Ile Ala Thr Leu Leu Val Trp Ile Val Ile Gly 
945                 950                 955                 960 


Phe Leu Asn Phe Glu Ile Val Glu Thr Tyr Phe Pro Gly Tyr Asn Arg 
                965                 970                 975     


Ser Ile Ser Arg Thr Glu Thr Ile Ile Arg Phe Ala Phe Gln Ala Ser 
            980                 985                 990         


Ile Thr Val Leu Cys Ile Ala Cys  Pro Cys Ser Leu Gly  Leu Ala Thr 
        995                 1000                 1005             


Pro Thr  Ala Val Met Val Gly  Thr Gly Val Gly Ala  Gln Asn Gly 
    1010                 1015                 1020             


Ile Leu  Ile Lys Gly Gly Glu  Pro Leu Glu Met Ala  His Lys Val 
    1025                 1030                 1035             


Lys Val  Val Val Phe Asp Lys  Thr Gly Thr Ile Thr  His Gly Thr 
    1040                 1045                 1050             


Pro Val  Val Asn Gln Val Lys  Val Leu Thr Glu Ser  Asn Arg Ile 
    1055                 1060                 1065             


Ser His  His Lys Ile Leu Ala  Ile Val Gly Thr Ala  Glu Ser Asn 
    1070                 1075                 1080             


Ser Glu  His Pro Leu Gly Thr  Ala Ile Thr Lys Tyr  Cys Lys Gln 
    1085                 1090                 1095             


Glu Leu  Asp Thr Glu Thr Leu  Gly Thr Cys Ile Asp  Phe Gln Val 
    1100                 1105                 1110             


Val Pro  Gly Cys Gly Ile Ser  Cys Lys Val Thr Asn  Ile Glu Gly 
    1115                 1120                 1125             


Leu Leu  His Lys Asn Asn Trp  Asn Ile Glu Asp Asn  Asn Ile Lys 
    1130                 1135                 1140             


Asn Ala  Ser Leu Val Gln Ile  Asp Ala Ser Asn Glu  Gln Ser Ser 
    1145                 1150                 1155             


Thr Ser  Ser Ser Met Ile Ile  Asp Ala Gln Ile Ser  Asn Ala Leu 
    1160                 1165                 1170             


Asn Ala  Gln Gln Tyr Lys Val  Leu Ile Gly Asn Arg  Glu Trp Met 
    1175                 1180                 1185             


Ile Arg  Asn Gly Leu Val Ile  Asn Asn Asp Val Asn  Asp Phe Met 
    1190                 1195                 1200             


Thr Glu  His Glu Arg Lys Gly  Arg Thr Ala Val Leu  Val Ala Val 
    1205                 1210                 1215             


Asp Asp  Glu Leu Cys Gly Leu  Ile Ala Ile Ala Asp  Thr Val Lys 
    1220                 1225                 1230             


Pro Glu  Ala Glu Leu Ala Ile  His Ile Leu Lys Ser  Met Gly Leu 
    1235                 1240                 1245             


Glu Val  Val Leu Met Thr Gly  Asp Asn Ser Lys Thr  Ala Arg Ser 
    1250                 1255                 1260             


Ile Ala  Ser Gln Val Gly Ile  Thr Lys Val Phe Ala  Glu Val Leu 
    1265                 1270                 1275             


Pro Ser  His Lys Val Ala Lys  Val Lys Gln Leu Gln  Glu Glu Gly 
    1280                 1285                 1290             


Lys Arg  Val Ala Met Val Gly  Asp Gly Ile Asn Asp  Ser Pro Ala 
    1295                 1300                 1305             


Leu Ala  Met Ala Asn Val Gly  Ile Ala Ile Gly Thr  Gly Thr Asp 
    1310                 1315                 1320             


Val Ala  Ile Glu Ala Ala Asp  Val Val Leu Ile Arg  Asn Asp Leu 
    1325                 1330                 1335             


Leu Asp  Val Val Ala Ser Ile  Asp Leu Ser Arg Lys  Thr Val Lys 
    1340                 1345                 1350             


Arg Ile  Arg Ile Asn Phe Val  Phe Ala Leu Ile Tyr  Asn Leu Val 
    1355                 1360                 1365             


Gly Ile  Pro Ile Ala Ala Gly  Val Phe Met Pro Ile  Gly Leu Val 
    1370                 1375                 1380             


Leu Gln  Pro Trp Met Gly Ser  Ala Ala Met Ala Ala  Ser Ser Val 
    1385                 1390                 1395             


Ser Val  Val Leu Ser Ser Leu  Phe Leu Lys Leu Tyr  Arg Lys Pro 
    1400                 1405                 1410             


Thr Tyr  Glu Ser Tyr Glu Leu  Pro Ala Arg Ser Gln  Ile Gly Gln 
    1415                 1420                 1425             


Lys Ser  Pro Ser Glu Ile Ser  Val His Val Gly Ile  Asp Asp Thr 
    1430                 1435                 1440             


Ser Arg  Asn Ser Pro Lys Leu  Gly Leu Leu Asp Arg  Ile Val Asn 
    1445                 1450                 1455             


Tyr Ser  Arg Ala Ser Ile Asn  Ser Leu Leu Ser Asp  Lys Arg Ser 
    1460                 1465                 1470             


Leu Asn  Ser Val Val Thr Ser  Glu Pro Asp Lys His  Ser Leu Leu 
    1475                 1480                 1485             


Val Gly  Asp Phe Arg Glu Asp  Asp Asp Thr Ala Leu  
    1490                 1495                 1500 


<210>  127
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aquaporin-7 UniProt record number: O14520

<400>  127

Met Val Gln Ala Ser Gly His Arg Arg Ser Thr Arg Gly Ser Lys Met 
1               5                   10                  15      


Val Ser Trp Ser Val Ile Ala Lys Ile Gln Glu Ile Leu Gln Arg Lys 
            20                  25                  30          


Met Val Arg Glu Phe Leu Ala Glu Phe Met Ser Thr Tyr Val Met Met 
        35                  40                  45              


Val Phe Gly Leu Gly Ser Val Ala His Met Val Leu Asn Lys Lys Tyr 
    50                  55                  60                  


Gly Ser Tyr Leu Gly Val Asn Leu Gly Phe Gly Phe Gly Val Thr Met 
65                  70                  75                  80  


Gly Val His Val Ala Gly Arg Ile Ser Gly Ala His Met Asn Ala Ala 
                85                  90                  95      


Val Thr Phe Ala Asn Cys Ala Leu Gly Arg Val Pro Trp Arg Lys Phe 
            100                 105                 110         


Pro Val Tyr Val Leu Gly Gln Phe Leu Gly Ser Phe Leu Ala Ala Ala 
        115                 120                 125             


Thr Ile Tyr Ser Leu Phe Tyr Thr Ala Ile Leu His Phe Ser Gly Gly 
    130                 135                 140                 


Gln Leu Met Val Thr Gly Pro Val Ala Thr Ala Gly Ile Phe Ala Thr 
145                 150                 155                 160 


Tyr Leu Pro Asp His Met Thr Leu Trp Arg Gly Phe Leu Asn Glu Ala 
                165                 170                 175     


Trp Leu Thr Gly Met Leu Gln Leu Cys Leu Phe Ala Ile Thr Asp Gln 
            180                 185                 190         


Glu Asn Asn Pro Ala Leu Pro Gly Thr Glu Ala Leu Val Ile Gly Ile 
        195                 200                 205             


Leu Val Val Ile Ile Gly Val Ser Leu Gly Met Asn Thr Gly Tyr Ala 
    210                 215                 220                 


Ile Asn Pro Ser Arg Asp Leu Pro Pro Arg Ile Phe Thr Phe Ile Ala 
225                 230                 235                 240 


Gly Trp Gly Lys Gln Val Phe Ser Asn Gly Glu Asn Trp Trp Trp Val 
                245                 250                 255     


Pro Val Val Ala Pro Leu Leu Gly Ala Tyr Leu Gly Gly Ile Ile Tyr 
            260                 265                 270         


Leu Val Phe Ile Gly Ser Thr Ile Pro Arg Glu Pro Leu Lys Leu Glu 
        275                 280                 285             


Asp Ser Val Ala Tyr Glu Asp His Gly Ile Thr Val Leu Pro Lys Met 
    290                 295                 300                 


Gly Ser His Glu Pro Thr Ile Ser Pro Leu Thr Pro Val Ser Val Ser 
305                 310                 315                 320 


Pro Ala Asn Arg Ser Ser Val His Pro Ala Pro Pro Leu His Glu Ser 
                325                 330                 335     


Met Ala Leu Glu His Phe 
            340         


<210>  128
<211>  664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Solute carrier family 5 member 1 or Sodium/glucose cotransporter 
       1 UniProt record number: P13866

<400>  128

Met Asp Ser Ser Thr Trp Ser Pro Lys Thr Thr Ala Val Thr Arg Pro 
1               5                   10                  15      


Val Glu Thr His Glu Leu Ile Arg Asn Ala Ala Asp Ile Ser Ile Ile 
            20                  25                  30          


Val Ile Tyr Phe Val Val Val Met Ala Val Gly Leu Trp Ala Met Phe 
        35                  40                  45              


Ser Thr Asn Arg Gly Thr Val Gly Gly Phe Phe Leu Ala Gly Arg Ser 
    50                  55                  60                  


Met Val Trp Trp Pro Ile Gly Ala Ser Leu Phe Ala Ser Asn Ile Gly 
65                  70                  75                  80  


Ser Gly His Phe Val Gly Leu Ala Gly Thr Gly Ala Ala Ser Gly Ile 
                85                  90                  95      


Ala Ile Gly Gly Phe Glu Trp Asn Ala Leu Val Leu Val Val Val Leu 
            100                 105                 110         


Gly Trp Leu Phe Val Pro Ile Tyr Ile Lys Ala Gly Val Val Thr Met 
        115                 120                 125             


Pro Glu Tyr Leu Arg Lys Arg Phe Gly Gly Gln Arg Ile Gln Val Tyr 
    130                 135                 140                 


Leu Ser Leu Leu Ser Leu Leu Leu Tyr Ile Phe Thr Lys Ile Ser Ala 
145                 150                 155                 160 


Asp Ile Phe Ser Gly Ala Ile Phe Ile Asn Leu Ala Leu Gly Leu Asn 
                165                 170                 175     


Leu Tyr Leu Ala Ile Phe Leu Leu Leu Ala Ile Thr Ala Leu Tyr Thr 
            180                 185                 190         


Ile Thr Gly Gly Leu Ala Ala Val Ile Tyr Thr Asp Thr Leu Gln Thr 
        195                 200                 205             


Val Ile Met Leu Val Gly Ser Leu Ile Leu Thr Gly Phe Ala Phe His 
    210                 215                 220                 


Glu Val Gly Gly Tyr Asp Ala Phe Met Glu Lys Tyr Met Lys Ala Ile 
225                 230                 235                 240 


Pro Thr Ile Val Ser Asp Gly Asn Thr Thr Phe Gln Glu Lys Cys Tyr 
                245                 250                 255     


Thr Pro Arg Ala Asp Ser Phe His Ile Phe Arg Asp Pro Leu Thr Gly 
            260                 265                 270         


Asp Leu Pro Trp Pro Gly Phe Ile Phe Gly Met Ser Ile Leu Thr Leu 
        275                 280                 285             


Trp Tyr Trp Cys Thr Asp Gln Val Ile Val Gln Arg Cys Leu Ser Ala 
    290                 295                 300                 


Lys Asn Met Ser His Val Lys Gly Gly Cys Ile Leu Cys Gly Tyr Leu 
305                 310                 315                 320 


Lys Leu Met Pro Met Phe Ile Met Val Met Pro Gly Met Ile Ser Arg 
                325                 330                 335     


Ile Leu Tyr Thr Glu Lys Ile Ala Cys Val Val Pro Ser Glu Cys Glu 
            340                 345                 350         


Lys Tyr Cys Gly Thr Lys Val Gly Cys Thr Asn Ile Ala Tyr Pro Thr 
        355                 360                 365             


Leu Val Val Glu Leu Met Pro Asn Gly Leu Arg Gly Leu Met Leu Ser 
    370                 375                 380                 


Val Met Leu Ala Ser Leu Met Ser Ser Leu Thr Ser Ile Phe Asn Ser 
385                 390                 395                 400 


Ala Ser Thr Leu Phe Thr Met Asp Ile Tyr Ala Lys Val Arg Lys Arg 
                405                 410                 415     


Ala Ser Glu Lys Glu Leu Met Ile Ala Gly Arg Leu Phe Ile Leu Val 
            420                 425                 430         


Leu Ile Gly Ile Ser Ile Ala Trp Val Pro Ile Val Gln Ser Ala Gln 
        435                 440                 445             


Ser Gly Gln Leu Phe Asp Tyr Ile Gln Ser Ile Thr Ser Tyr Leu Gly 
    450                 455                 460                 


Pro Pro Ile Ala Ala Val Phe Leu Leu Ala Ile Phe Trp Lys Arg Val 
465                 470                 475                 480 


Asn Glu Pro Gly Ala Phe Trp Gly Leu Ile Leu Gly Leu Leu Ile Gly 
                485                 490                 495     


Ile Ser Arg Met Ile Thr Glu Phe Ala Tyr Gly Thr Gly Ser Cys Met 
            500                 505                 510         


Glu Pro Ser Asn Cys Pro Thr Ile Ile Cys Gly Val His Tyr Leu Tyr 
        515                 520                 525             


Phe Ala Ile Ile Leu Phe Ala Ile Ser Phe Ile Thr Ile Val Val Ile 
    530                 535                 540                 


Ser Leu Leu Thr Lys Pro Ile Pro Asp Val His Leu Tyr Arg Leu Cys 
545                 550                 555                 560 


Trp Ser Leu Arg Asn Ser Lys Glu Glu Arg Ile Asp Leu Asp Ala Glu 
                565                 570                 575     


Glu Glu Asn Ile Gln Glu Gly Pro Lys Glu Thr Ile Glu Ile Glu Thr 
            580                 585                 590         


Gln Val Pro Glu Lys Lys Lys Gly Ile Phe Arg Arg Ala Tyr Asp Leu 
        595                 600                 605             


Phe Cys Gly Leu Glu Gln His Gly Ala Pro Lys Met Thr Glu Glu Glu 
    610                 615                 620                 


Glu Lys Ala Met Lys Met Lys Met Thr Asp Thr Ser Glu Lys Pro Leu 
625                 630                 635                 640 


Trp Arg Thr Val Leu Asn Val Asn Gly Ile Ile Leu Val Thr Val Ala 
                645                 650                 655     


Val Phe Cys His Ala Tyr Phe Ala 
            660                 


<210>  129
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Solute carrier family 16 member 2 or Monocarboxylate transporter 
       8 UniProt record number: P36021

<400>  129

Met Ala Leu Gln Ser Gln Ala Ser Glu Glu Ala Lys Gly Pro Trp Gln 
1               5                   10                  15      


Glu Ala Asp Gln Glu Gln Gln Glu Pro Val Gly Ser Pro Glu Pro Glu 
            20                  25                  30          


Ser Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Pro Val Pro Pro 
        35                  40                  45              


Pro Glu Pro Gln Pro Glu Pro Gln Pro Leu Pro Asp Pro Ala Pro Leu 
    50                  55                  60                  


Pro Glu Leu Glu Phe Glu Ser Glu Arg Val His Glu Pro Glu Pro Thr 
65                  70                  75                  80  


Pro Thr Val Glu Thr Arg Gly Thr Ala Arg Gly Phe Gln Pro Pro Glu 
                85                  90                  95      


Gly Gly Phe Gly Trp Val Val Val Phe Ala Ala Thr Trp Cys Asn Gly 
            100                 105                 110         


Ser Ile Phe Gly Ile His Asn Ser Val Gly Ile Leu Tyr Ser Met Leu 
        115                 120                 125             


Leu Glu Glu Glu Lys Glu Lys Asn Arg Gln Val Glu Phe Gln Ala Ala 
    130                 135                 140                 


Trp Val Gly Ala Leu Ala Met Gly Met Ile Phe Phe Cys Ser Pro Ile 
145                 150                 155                 160 


Val Ser Ile Phe Thr Asp Arg Leu Gly Cys Arg Ile Thr Ala Thr Ala 
                165                 170                 175     


Gly Ala Ala Val Ala Phe Ile Gly Leu His Thr Ser Ser Phe Thr Ser 
            180                 185                 190         


Ser Leu Ser Leu Arg Tyr Phe Thr Tyr Gly Ile Leu Phe Gly Cys Gly 
        195                 200                 205             


Cys Ser Phe Ala Phe Gln Pro Ser Leu Val Ile Leu Gly His Tyr Phe 
    210                 215                 220                 


Gln Arg Arg Leu Gly Leu Ala Asn Gly Val Val Ser Ala Gly Ser Ser 
225                 230                 235                 240 


Ile Phe Ser Met Ser Phe Pro Phe Leu Ile Arg Met Leu Gly Asp Lys 
                245                 250                 255     


Ile Lys Leu Ala Gln Thr Phe Gln Val Leu Ser Thr Phe Met Phe Val 
            260                 265                 270         


Leu Met Leu Leu Ser Leu Thr Tyr Arg Pro Leu Leu Pro Ser Ser Gln 
        275                 280                 285             


Asp Thr Pro Ser Lys Arg Gly Val Arg Thr Leu His Gln Arg Phe Leu 
    290                 295                 300                 


Ala Gln Leu Arg Lys Tyr Phe Asn Met Arg Val Phe Arg Gln Arg Thr 
305                 310                 315                 320 


Tyr Arg Ile Trp Ala Phe Gly Ile Ala Ala Ala Ala Leu Gly Tyr Phe 
                325                 330                 335     


Val Pro Tyr Val His Leu Met Lys Tyr Val Glu Glu Glu Phe Ser Glu 
            340                 345                 350         


Ile Lys Glu Thr Trp Val Leu Leu Val Cys Ile Gly Ala Thr Ser Gly 
        355                 360                 365             


Leu Gly Arg Leu Val Ser Gly His Ile Ser Asp Ser Ile Pro Gly Leu 
    370                 375                 380                 


Lys Lys Ile Tyr Leu Gln Val Leu Ser Phe Leu Leu Leu Gly Leu Met 
385                 390                 395                 400 


Ser Met Met Ile Pro Leu Cys Arg Asp Phe Gly Gly Leu Ile Val Val 
                405                 410                 415     


Cys Leu Phe Leu Gly Leu Cys Asp Gly Phe Phe Ile Thr Ile Met Ala 
            420                 425                 430         


Pro Ile Ala Phe Glu Leu Val Gly Pro Met Gln Ala Ser Gln Ala Ile 
        435                 440                 445             


Gly Tyr Leu Leu Gly Met Met Ala Leu Pro Met Ile Ala Gly Pro Pro 
    450                 455                 460                 


Ile Ala Gly Leu Leu Arg Asn Cys Phe Gly Asp Tyr His Val Ala Phe 
465                 470                 475                 480 


Tyr Phe Ala Gly Val Pro Pro Ile Ile Gly Ala Val Ile Leu Phe Phe 
                485                 490                 495     


Val Pro Leu Met His Gln Arg Met Phe Lys Lys Glu Gln Arg Asp Ser 
            500                 505                 510         


Ser Lys Asp Lys Met Leu Ala Pro Asp Pro Asp Pro Asn Gly Glu Leu 
        515                 520                 525             


Leu Pro Gly Ser Pro Asn Pro Glu Glu Pro Ile 
    530                 535                 


<210>  130
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Solute carrier family 7 member 9 or b(0,+)-type amino acid 
       transporter 1 UniProt record number: P82251

<400>  130

Met Gly Asp Thr Gly Leu Arg Lys Arg Arg Glu Asp Glu Lys Ser Ile 
1               5                   10                  15      


Gln Ser Gln Glu Pro Lys Thr Thr Ser Leu Gln Lys Glu Leu Gly Leu 
            20                  25                  30          


Ile Ser Gly Ile Ser Ile Ile Val Gly Thr Ile Ile Gly Ser Gly Ile 
        35                  40                  45              


Phe Val Ser Pro Lys Ser Val Leu Ser Asn Thr Glu Ala Val Gly Pro 
    50                  55                  60                  


Cys Leu Ile Ile Trp Ala Ala Cys Gly Val Leu Ala Thr Leu Gly Ala 
65                  70                  75                  80  


Leu Cys Phe Ala Glu Leu Gly Thr Met Ile Thr Lys Ser Gly Gly Glu 
                85                  90                  95      


Tyr Pro Tyr Leu Met Glu Ala Tyr Gly Pro Ile Pro Ala Tyr Leu Phe 
            100                 105                 110         


Ser Trp Ala Ser Leu Ile Val Ile Lys Pro Thr Ser Phe Ala Ile Ile 
        115                 120                 125             


Cys Leu Ser Phe Ser Glu Tyr Val Cys Ala Pro Phe Tyr Val Gly Cys 
    130                 135                 140                 


Lys Pro Pro Gln Ile Val Val Lys Cys Leu Ala Ala Ala Ala Ile Leu 
145                 150                 155                 160 


Phe Ile Ser Thr Val Asn Ser Leu Ser Val Arg Leu Gly Ser Tyr Val 
                165                 170                 175     


Gln Asn Ile Phe Thr Ala Ala Lys Leu Val Ile Val Ala Ile Ile Ile 
            180                 185                 190         


Ile Ser Gly Leu Val Leu Leu Ala Gln Gly Asn Thr Lys Asn Phe Asp 
        195                 200                 205             


Asn Ser Phe Glu Gly Ala Gln Leu Ser Val Gly Ala Ile Ser Leu Ala 
    210                 215                 220                 


Phe Tyr Asn Gly Leu Trp Ala Tyr Asp Gly Trp Asn Gln Leu Asn Tyr 
225                 230                 235                 240 


Ile Thr Glu Glu Leu Arg Asn Pro Tyr Arg Asn Leu Pro Leu Ala Ile 
                245                 250                 255     


Ile Ile Gly Ile Pro Leu Val Thr Ala Cys Tyr Ile Leu Met Asn Val 
            260                 265                 270         


Ser Tyr Phe Thr Val Met Thr Ala Thr Glu Leu Leu Gln Ser Gln Ala 
        275                 280                 285             


Val Ala Val Thr Phe Gly Asp Arg Val Leu Tyr Pro Ala Ser Trp Ile 
    290                 295                 300                 


Val Pro Leu Phe Val Ala Phe Ser Thr Ile Gly Ala Ala Asn Gly Thr 
305                 310                 315                 320 


Cys Phe Thr Ala Gly Arg Leu Ile Tyr Val Ala Gly Arg Glu Gly His 
                325                 330                 335     


Met Leu Lys Val Leu Ser Tyr Ile Ser Val Arg Arg Leu Thr Pro Ala 
            340                 345                 350         


Pro Ala Ile Ile Phe Tyr Gly Ile Ile Ala Thr Ile Tyr Ile Ile Pro 
        355                 360                 365             


Gly Asp Ile Asn Ser Leu Val Asn Tyr Phe Ser Phe Ala Ala Trp Leu 
    370                 375                 380                 


Phe Tyr Gly Leu Thr Ile Leu Gly Leu Ile Val Met Arg Phe Thr Arg 
385                 390                 395                 400 


Lys Glu Leu Glu Arg Pro Ile Lys Val Pro Val Val Ile Pro Val Leu 
                405                 410                 415     


Met Thr Leu Ile Ser Val Phe Leu Val Leu Ala Pro Ile Ile Ser Lys 
            420                 425                 430         


Pro Thr Trp Glu Tyr Leu Tyr Cys Val Leu Phe Ile Leu Ser Gly Leu 
        435                 440                 445             


Leu Phe Tyr Phe Leu Phe Val His Tyr Lys Phe Gly Trp Ala Gln Lys 
    450                 455                 460                 


Ile Ser Lys Pro Ile Thr Met His Leu Gln Met Leu Met Glu Val Val 
465                 470                 475                 480 


Pro Pro Glu Glu Asp Pro Glu 
                485         


<210>  131
<211>  1286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP-binding cassette sub-family B (MDR) member 4 or 
       Phosphatidylcholine translocator ABCB4 UniProt record number: 
       P21439

<400>  131

Met Asp Leu Glu Ala Ala Lys Asn Gly Thr Ala Trp Arg Pro Thr Ser 
1               5                   10                  15      


Ala Glu Gly Asp Phe Glu Leu Gly Ile Ser Ser Lys Gln Lys Arg Lys 
            20                  25                  30          


Lys Thr Lys Thr Val Lys Met Ile Gly Val Leu Thr Leu Phe Arg Tyr 
        35                  40                  45              


Ser Asp Trp Gln Asp Lys Leu Phe Met Ser Leu Gly Thr Ile Met Ala 
    50                  55                  60                  


Ile Ala His Gly Ser Gly Leu Pro Leu Met Met Ile Val Phe Gly Glu 
65                  70                  75                  80  


Met Thr Asp Lys Phe Val Asp Thr Ala Gly Asn Phe Ser Phe Pro Val 
                85                  90                  95      


Asn Phe Ser Leu Ser Leu Leu Asn Pro Gly Lys Ile Leu Glu Glu Glu 
            100                 105                 110         


Met Thr Arg Tyr Ala Tyr Tyr Tyr Ser Gly Leu Gly Ala Gly Val Leu 
        115                 120                 125             


Val Ala Ala Tyr Ile Gln Val Ser Phe Trp Thr Leu Ala Ala Gly Arg 
    130                 135                 140                 


Gln Ile Arg Lys Ile Arg Gln Lys Phe Phe His Ala Ile Leu Arg Gln 
145                 150                 155                 160 


Glu Ile Gly Trp Phe Asp Ile Asn Asp Thr Thr Glu Leu Asn Thr Arg 
                165                 170                 175     


Leu Thr Asp Asp Ile Ser Lys Ile Ser Glu Gly Ile Gly Asp Lys Val 
            180                 185                 190         


Gly Met Phe Phe Gln Ala Val Ala Thr Phe Phe Ala Gly Phe Ile Val 
        195                 200                 205             


Gly Phe Ile Arg Gly Trp Lys Leu Thr Leu Val Ile Met Ala Ile Ser 
    210                 215                 220                 


Pro Ile Leu Gly Leu Ser Ala Ala Val Trp Ala Lys Ile Leu Ser Ala 
225                 230                 235                 240 


Phe Ser Asp Lys Glu Leu Ala Ala Tyr Ala Lys Ala Gly Ala Val Ala 
                245                 250                 255     


Glu Glu Ala Leu Gly Ala Ile Arg Thr Val Ile Ala Phe Gly Gly Gln 
            260                 265                 270         


Asn Lys Glu Leu Glu Arg Tyr Gln Lys His Leu Glu Asn Ala Lys Glu 
        275                 280                 285             


Ile Gly Ile Lys Lys Ala Ile Ser Ala Asn Ile Ser Met Gly Ile Ala 
    290                 295                 300                 


Phe Leu Leu Ile Tyr Ala Ser Tyr Ala Leu Ala Phe Trp Tyr Gly Ser 
305                 310                 315                 320 


Thr Leu Val Ile Ser Lys Glu Tyr Thr Ile Gly Asn Ala Met Thr Val 
                325                 330                 335     


Phe Phe Ser Ile Leu Ile Gly Ala Phe Ser Val Gly Gln Ala Ala Pro 
            340                 345                 350         


Cys Ile Asp Ala Phe Ala Asn Ala Arg Gly Ala Ala Tyr Val Ile Phe 
        355                 360                 365             


Asp Ile Ile Asp Asn Asn Pro Lys Ile Asp Ser Phe Ser Glu Arg Gly 
    370                 375                 380                 


His Lys Pro Asp Ser Ile Lys Gly Asn Leu Glu Phe Asn Asp Val His 
385                 390                 395                 400 


Phe Ser Tyr Pro Ser Arg Ala Asn Val Lys Ile Leu Lys Gly Leu Asn 
                405                 410                 415     


Leu Lys Val Gln Ser Gly Gln Thr Val Ala Leu Val Gly Ser Ser Gly 
            420                 425                 430         


Cys Gly Lys Ser Thr Thr Val Gln Leu Ile Gln Arg Leu Tyr Asp Pro 
        435                 440                 445             


Asp Glu Gly Thr Ile Asn Ile Asp Gly Gln Asp Ile Arg Asn Phe Asn 
    450                 455                 460                 


Val Asn Tyr Leu Arg Glu Ile Ile Gly Val Val Ser Gln Glu Pro Val 
465                 470                 475                 480 


Leu Phe Ser Thr Thr Ile Ala Glu Asn Ile Cys Tyr Gly Arg Gly Asn 
                485                 490                 495     


Val Thr Met Asp Glu Ile Lys Lys Ala Val Lys Glu Ala Asn Ala Tyr 
            500                 505                 510         


Glu Phe Ile Met Lys Leu Pro Gln Lys Phe Asp Thr Leu Val Gly Glu 
        515                 520                 525             


Arg Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Ile Ala 
    530                 535                 540                 


Arg Ala Leu Val Arg Asn Pro Lys Ile Leu Leu Leu Asp Glu Ala Thr 
545                 550                 555                 560 


Ser Ala Leu Asp Thr Glu Ser Glu Ala Glu Val Gln Ala Ala Leu Asp 
                565                 570                 575     


Lys Ala Arg Glu Gly Arg Thr Thr Ile Val Ile Ala His Arg Leu Ser 
            580                 585                 590         


Thr Val Arg Asn Ala Asp Val Ile Ala Gly Phe Glu Asp Gly Val Ile 
        595                 600                 605             


Val Glu Gln Gly Ser His Ser Glu Leu Met Lys Lys Glu Gly Val Tyr 
    610                 615                 620                 


Phe Lys Leu Val Asn Met Gln Thr Ser Gly Ser Gln Ile Gln Ser Glu 
625                 630                 635                 640 


Glu Phe Glu Leu Asn Asp Glu Lys Ala Ala Thr Arg Met Ala Pro Asn 
                645                 650                 655     


Gly Trp Lys Ser Arg Leu Phe Arg His Ser Thr Gln Lys Asn Leu Lys 
            660                 665                 670         


Asn Ser Gln Met Cys Gln Lys Ser Leu Asp Val Glu Thr Asp Gly Leu 
        675                 680                 685             


Glu Ala Asn Val Pro Pro Val Ser Phe Leu Lys Val Leu Lys Leu Asn 
    690                 695                 700                 


Lys Thr Glu Trp Pro Tyr Phe Val Val Gly Thr Val Cys Ala Ile Ala 
705                 710                 715                 720 


Asn Gly Gly Leu Gln Pro Ala Phe Ser Val Ile Phe Ser Glu Ile Ile 
                725                 730                 735     


Ala Ile Phe Gly Pro Gly Asp Asp Ala Val Lys Gln Gln Lys Cys Asn 
            740                 745                 750         


Ile Phe Ser Leu Ile Phe Leu Phe Leu Gly Ile Ile Ser Phe Phe Thr 
        755                 760                 765             


Phe Phe Leu Gln Gly Phe Thr Phe Gly Lys Ala Gly Glu Ile Leu Thr 
    770                 775                 780                 


Arg Arg Leu Arg Ser Met Ala Phe Lys Ala Met Leu Arg Gln Asp Met 
785                 790                 795                 800 


Ser Trp Phe Asp Asp His Lys Asn Ser Thr Gly Ala Leu Ser Thr Arg 
                805                 810                 815     


Leu Ala Thr Asp Ala Ala Gln Val Gln Gly Ala Thr Gly Thr Arg Leu 
            820                 825                 830         


Ala Leu Ile Ala Gln Asn Ile Ala Asn Leu Gly Thr Gly Ile Ile Ile 
        835                 840                 845             


Ser Phe Ile Tyr Gly Trp Gln Leu Thr Leu Leu Leu Leu Ala Val Val 
    850                 855                 860                 


Pro Ile Ile Ala Val Ser Gly Ile Val Glu Met Lys Leu Leu Ala Gly 
865                 870                 875                 880 


Asn Ala Lys Arg Asp Lys Lys Glu Leu Glu Ala Ala Gly Lys Ile Ala 
                885                 890                 895     


Thr Glu Ala Ile Glu Asn Ile Arg Thr Val Val Ser Leu Thr Gln Glu 
            900                 905                 910         


Arg Lys Phe Glu Ser Met Tyr Val Glu Lys Leu Tyr Gly Pro Tyr Arg 
        915                 920                 925             


Asn Ser Val Gln Lys Ala His Ile Tyr Gly Ile Thr Phe Ser Ile Ser 
    930                 935                 940                 


Gln Ala Phe Met Tyr Phe Ser Tyr Ala Gly Cys Phe Arg Phe Gly Ala 
945                 950                 955                 960 


Tyr Leu Ile Val Asn Gly His Met Arg Phe Arg Asp Val Ile Leu Val 
                965                 970                 975     


Phe Ser Ala Ile Val Phe Gly Ala Val Ala Leu Gly His Ala Ser Ser 
            980                 985                 990         


Phe Ala Pro Asp Tyr Ala Lys Ala  Lys Leu Ser Ala Ala  His Leu Phe 
        995                 1000                 1005             


Met Leu  Phe Glu Arg Gln Pro  Leu Ile Asp Ser Tyr  Ser Glu Glu 
    1010                 1015                 1020             


Gly Leu  Lys Pro Asp Lys Phe  Glu Gly Asn Ile Thr  Phe Asn Glu 
    1025                 1030                 1035             


Val Val  Phe Asn Tyr Pro Thr  Arg Ala Asn Val Pro  Val Leu Gln 
    1040                 1045                 1050             


Gly Leu  Ser Leu Glu Val Lys  Lys Gly Gln Thr Leu  Ala Leu Val 
    1055                 1060                 1065             


Gly Ser  Ser Gly Cys Gly Lys  Ser Thr Val Val Gln  Leu Leu Glu 
    1070                 1075                 1080             


Arg Phe  Tyr Asp Pro Leu Ala  Gly Thr Val Phe Val  Asp Phe Gly 
    1085                 1090                 1095             


Phe Gln  Leu Leu Asp Gly Gln  Glu Ala Lys Lys Leu  Asn Val Gln 
    1100                 1105                 1110             


Trp Leu  Arg Ala Gln Leu Gly  Ile Val Ser Gln Glu  Pro Ile Leu 
    1115                 1120                 1125             


Phe Asp  Cys Ser Ile Ala Glu  Asn Ile Ala Tyr Gly  Asp Asn Ser 
    1130                 1135                 1140             


Arg Val  Val Ser Gln Asp Glu  Ile Val Ser Ala Ala  Lys Ala Ala 
    1145                 1150                 1155             


Asn Ile  His Pro Phe Ile Glu  Thr Leu Pro His Lys  Tyr Glu Thr 
    1160                 1165                 1170             


Arg Val  Gly Asp Lys Gly Thr  Gln Leu Ser Gly Gly  Gln Lys Gln 
    1175                 1180                 1185             


Arg Ile  Ala Ile Ala Arg Ala  Leu Ile Arg Gln Pro  Gln Ile Leu 
    1190                 1195                 1200             


Leu Leu  Asp Glu Ala Thr Ser  Ala Leu Asp Thr Glu  Ser Glu Lys 
    1205                 1210                 1215             


Val Val  Gln Glu Ala Leu Asp  Lys Ala Arg Glu Gly  Arg Thr Cys 
    1220                 1225                 1230             


Ile Val  Ile Ala His Arg Leu  Ser Thr Ile Gln Asn  Ala Asp Leu 
    1235                 1240                 1245             


Ile Val  Val Phe Gln Asn Gly  Arg Val Lys Glu His  Gly Thr His 
    1250                 1255                 1260             


Gln Gln  Leu Leu Ala Gln Lys  Gly Ile Tyr Phe Ser  Met Val Ser 
    1265                 1270                 1275             


Val Gln  Ala Gly Thr Gln Asn  Leu 
    1280                 1285     


<210>  132
<211>  1382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP-binding cassette sub-family C member 11 UniProt record 
       number: Q96J66

<400>  132

Met Thr Arg Lys Arg Thr Tyr Trp Val Pro Asn Ser Ser Gly Gly Leu 
1               5                   10                  15      


Val Asn Arg Gly Ile Asp Ile Gly Asp Asp Met Val Ser Gly Leu Ile 
            20                  25                  30          


Tyr Lys Thr Tyr Thr Leu Gln Asp Gly Pro Trp Ser Gln Gln Glu Arg 
        35                  40                  45              


Asn Pro Glu Ala Pro Gly Arg Ala Ala Val Pro Pro Trp Gly Lys Tyr 
    50                  55                  60                  


Asp Ala Ala Leu Arg Thr Met Ile Pro Phe Arg Pro Lys Pro Arg Phe 
65                  70                  75                  80  


Pro Ala Pro Gln Pro Leu Asp Asn Ala Gly Leu Phe Ser Tyr Leu Thr 
                85                  90                  95      


Val Ser Trp Leu Thr Pro Leu Met Ile Gln Ser Leu Arg Ser Arg Leu 
            100                 105                 110         


Asp Glu Asn Thr Ile Pro Pro Leu Ser Val His Asp Ala Ser Asp Lys 
        115                 120                 125             


Asn Val Gln Arg Leu His Arg Leu Trp Glu Glu Glu Val Ser Arg Arg 
    130                 135                 140                 


Gly Ile Glu Lys Ala Ser Val Leu Leu Val Met Leu Arg Phe Gln Arg 
145                 150                 155                 160 


Thr Arg Leu Ile Phe Asp Ala Leu Leu Gly Ile Cys Phe Cys Ile Ala 
                165                 170                 175     


Ser Val Leu Gly Pro Ile Leu Ile Ile Pro Lys Ile Leu Glu Tyr Ser 
            180                 185                 190         


Glu Glu Gln Leu Gly Asn Val Val His Gly Val Gly Leu Cys Phe Ala 
        195                 200                 205             


Leu Phe Leu Ser Glu Cys Val Lys Ser Leu Ser Phe Ser Ser Ser Trp 
    210                 215                 220                 


Ile Ile Asn Gln Arg Thr Ala Ile Arg Phe Arg Ala Ala Val Ser Ser 
225                 230                 235                 240 


Phe Ala Phe Glu Lys Leu Ile Gln Phe Lys Ser Val Ile His Ile Thr 
                245                 250                 255     


Ser Gly Glu Ala Ile Ser Phe Phe Thr Gly Asp Val Asn Tyr Leu Phe 
            260                 265                 270         


Glu Gly Val Cys Tyr Gly Pro Leu Val Leu Ile Thr Cys Ala Ser Leu 
        275                 280                 285             


Val Ile Cys Ser Ile Ser Ser Tyr Phe Ile Ile Gly Tyr Thr Ala Phe 
    290                 295                 300                 


Ile Ala Ile Leu Cys Tyr Leu Leu Val Phe Pro Leu Ala Val Phe Met 
305                 310                 315                 320 


Thr Arg Met Ala Val Lys Ala Gln His His Thr Ser Glu Val Ser Asp 
                325                 330                 335     


Gln Arg Ile Arg Val Thr Ser Glu Val Leu Thr Cys Ile Lys Leu Ile 
            340                 345                 350         


Lys Met Tyr Thr Trp Glu Lys Pro Phe Ala Lys Ile Ile Glu Asp Leu 
        355                 360                 365             


Arg Arg Lys Glu Arg Lys Leu Leu Glu Lys Cys Gly Leu Val Gln Ser 
    370                 375                 380                 


Leu Thr Ser Ile Thr Leu Phe Ile Ile Pro Thr Val Ala Thr Ala Val 
385                 390                 395                 400 


Trp Val Leu Ile His Thr Ser Leu Lys Leu Lys Leu Thr Ala Ser Met 
                405                 410                 415     


Ala Phe Ser Met Leu Ala Ser Leu Asn Leu Leu Arg Leu Ser Val Phe 
            420                 425                 430         


Phe Val Pro Ile Ala Val Lys Gly Leu Thr Asn Ser Lys Ser Ala Val 
        435                 440                 445             


Met Arg Phe Lys Lys Phe Phe Leu Gln Glu Ser Pro Val Phe Tyr Val 
    450                 455                 460                 


Gln Thr Leu Gln Asp Pro Ser Lys Ala Leu Val Phe Glu Glu Ala Thr 
465                 470                 475                 480 


Leu Ser Trp Gln Gln Thr Cys Pro Gly Ile Val Asn Gly Ala Leu Glu 
                485                 490                 495     


Leu Glu Arg Asn Gly His Ala Ser Glu Gly Met Thr Arg Pro Arg Asp 
            500                 505                 510         


Ala Leu Gly Pro Glu Glu Glu Gly Asn Ser Leu Gly Pro Glu Leu His 
        515                 520                 525             


Lys Ile Asn Leu Val Val Ser Lys Gly Met Met Leu Gly Val Cys Gly 
    530                 535                 540                 


Asn Thr Gly Ser Gly Lys Ser Ser Leu Leu Ser Ala Ile Leu Glu Glu 
545                 550                 555                 560 


Met His Leu Leu Glu Gly Ser Val Gly Val Gln Gly Ser Leu Ala Tyr 
                565                 570                 575     


Val Pro Gln Gln Ala Trp Ile Val Ser Gly Asn Ile Arg Glu Asn Ile 
            580                 585                 590         


Leu Met Gly Gly Ala Tyr Asp Lys Ala Arg Tyr Leu Gln Val Leu His 
        595                 600                 605             


Cys Cys Ser Leu Asn Arg Asp Leu Glu Leu Leu Pro Phe Gly Asp Met 
    610                 615                 620                 


Thr Glu Ile Gly Glu Arg Gly Leu Asn Leu Ser Gly Gly Gln Lys Gln 
625                 630                 635                 640 


Arg Ile Ser Leu Ala Arg Ala Val Tyr Ser Asp Arg Gln Ile Tyr Leu 
                645                 650                 655     


Leu Asp Asp Pro Leu Ser Ala Val Asp Ala His Val Gly Lys His Ile 
            660                 665                 670         


Phe Glu Glu Cys Ile Lys Lys Thr Leu Arg Gly Lys Thr Val Val Leu 
        675                 680                 685             


Val Thr His Gln Leu Gln Tyr Leu Glu Phe Cys Gly Gln Ile Ile Leu 
    690                 695                 700                 


Leu Glu Asn Gly Lys Ile Cys Glu Asn Gly Thr His Ser Glu Leu Met 
705                 710                 715                 720 


Gln Lys Lys Gly Lys Tyr Ala Gln Leu Ile Gln Lys Met His Lys Glu 
                725                 730                 735     


Ala Thr Ser Asp Met Leu Gln Asp Thr Ala Lys Ile Ala Glu Lys Pro 
            740                 745                 750         


Lys Val Glu Ser Gln Ala Leu Ala Thr Ser Leu Glu Glu Ser Leu Asn 
        755                 760                 765             


Gly Asn Ala Val Pro Glu His Gln Leu Thr Gln Glu Glu Glu Met Glu 
    770                 775                 780                 


Glu Gly Ser Leu Ser Trp Arg Val Tyr His His Tyr Ile Gln Ala Ala 
785                 790                 795                 800 


Gly Gly Tyr Met Val Ser Cys Ile Ile Phe Phe Phe Val Val Leu Ile 
                805                 810                 815     


Val Phe Leu Thr Ile Phe Ser Phe Trp Trp Leu Ser Tyr Trp Leu Glu 
            820                 825                 830         


Gln Gly Ser Gly Thr Asn Ser Ser Arg Glu Ser Asn Gly Thr Met Ala 
        835                 840                 845             


Asp Leu Gly Asn Ile Ala Asp Asn Pro Gln Leu Ser Phe Tyr Gln Leu 
    850                 855                 860                 


Val Tyr Gly Leu Asn Ala Leu Leu Leu Ile Cys Val Gly Val Cys Ser 
865                 870                 875                 880 


Ser Gly Ile Phe Thr Lys Val Thr Arg Lys Ala Ser Thr Ala Leu His 
                885                 890                 895     


Asn Lys Leu Phe Asn Lys Val Phe Arg Cys Pro Met Ser Phe Phe Asp 
            900                 905                 910         


Thr Ile Pro Ile Gly Arg Leu Leu Asn Cys Phe Ala Gly Asp Leu Glu 
        915                 920                 925             


Gln Leu Asp Gln Leu Leu Pro Ile Phe Ser Glu Gln Phe Leu Val Leu 
    930                 935                 940                 


Ser Leu Met Val Ile Ala Val Leu Leu Ile Val Ser Val Leu Ser Pro 
945                 950                 955                 960 


Tyr Ile Leu Leu Met Gly Ala Ile Ile Met Val Ile Cys Phe Ile Tyr 
                965                 970                 975     


Tyr Met Met Phe Lys Lys Ala Ile Gly Val Phe Lys Arg Leu Glu Asn 
            980                 985                 990         


Tyr Ser Arg Ser Pro Leu Phe Ser  His Ile Leu Asn Ser  Leu Gln Gly 
        995                 1000                 1005             


Leu Ser  Ser Ile His Val Tyr  Gly Lys Thr Glu Asp  Phe Ile Ser 
    1010                 1015                 1020             


Gln Phe  Lys Arg Leu Thr Asp  Ala Gln Asn Asn Tyr  Leu Leu Leu 
    1025                 1030                 1035             


Phe Leu  Ser Ser Thr Arg Trp  Met Ala Leu Arg Leu  Glu Ile Met 
    1040                 1045                 1050             


Thr Asn  Leu Val Thr Leu Ala  Val Ala Leu Phe Val  Ala Phe Gly 
    1055                 1060                 1065             


Ile Ser  Ser Thr Pro Tyr Ser  Phe Lys Val Met Ala  Val Asn Ile 
    1070                 1075                 1080             


Val Leu  Gln Leu Ala Ser Ser  Phe Gln Ala Thr Ala  Arg Ile Gly 
    1085                 1090                 1095             


Leu Glu  Thr Glu Ala Gln Phe  Thr Ala Val Glu Arg  Ile Leu Gln 
    1100                 1105                 1110             


Tyr Met  Lys Met Cys Val Ser  Glu Ala Pro Leu His  Met Glu Gly 
    1115                 1120                 1125             


Thr Ser  Cys Pro Gln Gly Trp  Pro Gln His Gly Glu  Ile Ile Phe 
    1130                 1135                 1140             


Gln Asp  Tyr His Met Lys Tyr  Arg Asp Asn Thr Pro  Thr Val Leu 
    1145                 1150                 1155             


His Gly  Ile Asn Leu Thr Ile  Arg Gly His Glu Val  Val Gly Ile 
    1160                 1165                 1170             


Val Gly  Arg Thr Gly Ser Gly  Lys Ser Ser Leu Gly  Met Ala Leu 
    1175                 1180                 1185             


Phe Arg  Leu Val Glu Pro Met  Ala Gly Arg Ile Leu  Ile Asp Gly 
    1190                 1195                 1200             


Val Asp  Ile Cys Ser Ile Gly  Leu Glu Asp Leu Arg  Ser Lys Leu 
    1205                 1210                 1215             


Ser Val  Ile Pro Gln Asp Pro  Val Leu Leu Ser Gly  Thr Ile Arg 
    1220                 1225                 1230             


Phe Asn  Leu Asp Pro Phe Asp  Arg His Thr Asp Gln  Gln Ile Trp 
    1235                 1240                 1245             


Asp Ala  Leu Glu Arg Thr Phe  Leu Thr Lys Ala Ile  Ser Lys Phe 
    1250                 1255                 1260             


Pro Lys  Lys Leu His Thr Asp  Val Val Glu Asn Gly  Gly Asn Phe 
    1265                 1270                 1275             


Ser Val  Gly Glu Arg Gln Leu  Leu Cys Ile Ala Arg  Ala Val Leu 
    1280                 1285                 1290             


Arg Asn  Ser Lys Ile Ile Leu  Ile Asp Glu Ala Thr  Ala Ser Ile 
    1295                 1300                 1305             


Asp Met  Glu Thr Asp Thr Leu  Ile Gln Arg Thr Ile  Arg Glu Ala 
    1310                 1315                 1320             


Phe Gln  Gly Cys Thr Val Leu  Val Ile Ala His Arg  Val Thr Thr 
    1325                 1330                 1335             


Val Leu  Asn Cys Asp His Ile  Leu Val Met Gly Asn  Gly Lys Val 
    1340                 1345                 1350             


Val Glu  Phe Asp Arg Pro Glu  Val Leu Arg Lys Lys  Pro Gly Ser 
    1355                 1360                 1365             


Leu Phe  Ala Ala Leu Met Ala  Thr Ala Thr Ser Ser  Leu Arg 
    1370                 1375                 1380         


<210>  133
<211>  845
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP-binding cassette sub-family F member 1

       UniProt record number: Q8NE71

<400>  133

Met Pro Lys Ala Pro Lys Gln Gln Pro Pro Glu Pro Glu Trp Ile Gly 
1               5                   10                  15      


Asp Gly Glu Ser Thr Ser Pro Ser Asp Lys Val Val Lys Lys Gly Lys 
            20                  25                  30          


Lys Asp Lys Lys Ile Lys Lys Thr Phe Phe Glu Glu Leu Ala Val Glu 
        35                  40                  45              


Asp Lys Gln Ala Gly Glu Glu Glu Lys Val Leu Lys Glu Lys Glu Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Lys Lys Lys Arg Asp Thr Arg 
65                  70                  75                  80  


Lys Gly Arg Arg Lys Lys Asp Val Asp Asp Asp Gly Glu Glu Lys Glu 
                85                  90                  95      


Leu Met Glu Arg Leu Lys Lys Leu Ser Val Pro Thr Ser Asp Glu Glu 
            100                 105                 110         


Asp Glu Val Pro Ala Pro Lys Pro Arg Gly Gly Lys Lys Thr Lys Gly 
        115                 120                 125             


Gly Asn Val Phe Ala Ala Leu Ile Gln Asp Gln Ser Glu Glu Glu Glu 
    130                 135                 140                 


Glu Glu Glu Lys His Pro Pro Lys Pro Ala Lys Pro Glu Lys Asn Arg 
145                 150                 155                 160 


Ile Asn Lys Ala Val Ser Glu Glu Gln Gln Pro Ala Leu Lys Gly Lys 
                165                 170                 175     


Lys Gly Lys Glu Glu Lys Ser Lys Gly Lys Ala Lys Pro Gln Asn Lys 
            180                 185                 190         


Phe Ala Ala Leu Asp Asn Glu Glu Glu Asp Lys Glu Glu Glu Ile Ile 
        195                 200                 205             


Lys Glu Lys Glu Pro Pro Lys Gln Gly Lys Glu Lys Ala Lys Lys Ala 
    210                 215                 220                 


Glu Gln Gly Ser Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Glu Glu 
225                 230                 235                 240 


Gly Gly Glu Ser Lys Ala Asp Asp Pro Tyr Ala His Leu Ser Lys Lys 
                245                 250                 255     


Glu Lys Lys Lys Leu Lys Lys Gln Met Glu Tyr Glu Arg Gln Val Ala 
            260                 265                 270         


Ser Leu Lys Ala Ala Asn Ala Ala Glu Asn Asp Phe Ser Val Ser Gln 
        275                 280                 285             


Ala Glu Met Ser Ser Arg Gln Ala Met Leu Glu Asn Ala Ser Asp Ile 
    290                 295                 300                 


Lys Leu Glu Lys Phe Ser Ile Ser Ala His Gly Lys Glu Leu Phe Val 
305                 310                 315                 320 


Asn Ala Asp Leu Tyr Ile Val Ala Gly Arg Arg Tyr Gly Leu Val Gly 
                325                 330                 335     


Pro Asn Gly Lys Gly Lys Thr Thr Leu Leu Lys His Ile Ala Asn Arg 
            340                 345                 350         


Ala Leu Ser Ile Pro Pro Asn Ile Asp Val Leu Leu Cys Glu Gln Glu 
        355                 360                 365             


Val Val Ala Asp Glu Thr Pro Ala Val Gln Ala Val Leu Arg Ala Asp 
    370                 375                 380                 


Thr Lys Arg Leu Lys Leu Leu Glu Glu Glu Arg Arg Leu Gln Gly Gln 
385                 390                 395                 400 


Leu Glu Gln Gly Asp Asp Thr Ala Ala Glu Arg Leu Glu Lys Val Tyr 
                405                 410                 415     


Glu Glu Leu Arg Ala Thr Gly Ala Ala Ala Ala Glu Ala Lys Ala Arg 
            420                 425                 430         


Arg Ile Leu Ala Gly Leu Gly Phe Asp Pro Glu Met Gln Asn Arg Pro 
        435                 440                 445             


Thr Gln Lys Phe Ser Gly Gly Trp Arg Met Arg Val Ser Leu Ala Arg 
    450                 455                 460                 


Ala Leu Phe Met Glu Pro Thr Leu Leu Met Leu Asp Glu Pro Thr Asn 
465                 470                 475                 480 


His Leu Asp Leu Asn Ala Val Ile Trp Leu Asn Asn Tyr Leu Gln Gly 
                485                 490                 495     


Trp Arg Lys Thr Leu Leu Ile Val Ser His Asp Gln Gly Phe Leu Asp 
            500                 505                 510         


Asp Val Cys Thr Asp Ile Ile His Leu Asp Ala Gln Arg Leu His Tyr 
        515                 520                 525             


Tyr Arg Gly Asn Tyr Met Thr Phe Lys Lys Met Tyr Gln Gln Lys Gln 
    530                 535                 540                 


Lys Glu Leu Leu Lys Gln Tyr Glu Lys Gln Glu Lys Lys Leu Lys Glu 
545                 550                 555                 560 


Leu Lys Ala Gly Gly Lys Ser Thr Lys Gln Ala Glu Lys Gln Thr Lys 
                565                 570                 575     


Glu Ala Leu Thr Arg Lys Gln Gln Lys Cys Arg Arg Lys Asn Gln Asp 
            580                 585                 590         


Glu Glu Ser Gln Glu Ala Pro Glu Leu Leu Lys Arg Pro Lys Glu Tyr 
        595                 600                 605             


Thr Val Arg Phe Thr Phe Pro Asp Pro Pro Pro Leu Ser Pro Pro Val 
    610                 615                 620                 


Leu Gly Leu His Gly Val Thr Phe Gly Tyr Gln Gly Gln Lys Pro Leu 
625                 630                 635                 640 


Phe Lys Asn Leu Asp Phe Gly Ile Asp Met Asp Ser Arg Ile Cys Ile 
                645                 650                 655     


Val Gly Pro Asn Gly Val Gly Lys Ser Thr Leu Leu Leu Leu Leu Thr 
            660                 665                 670         


Gly Lys Leu Thr Pro Thr His Gly Glu Met Arg Lys Asn His Arg Leu 
        675                 680                 685             


Lys Ile Gly Phe Phe Asn Gln Gln Tyr Ala Glu Gln Leu Arg Met Glu 
    690                 695                 700                 


Glu Thr Pro Thr Glu Tyr Leu Gln Arg Gly Phe Asn Leu Pro Tyr Gln 
705                 710                 715                 720 


Asp Ala Arg Lys Cys Leu Gly Arg Phe Gly Leu Glu Ser His Ala His 
                725                 730                 735     


Thr Ile Gln Ile Cys Lys Leu Ser Gly Gly Gln Lys Ala Arg Val Val 
            740                 745                 750         


Phe Ala Glu Leu Ala Cys Arg Glu Pro Asp Val Leu Ile Leu Asp Glu 
        755                 760                 765             


Pro Thr Asn Asn Leu Asp Ile Glu Ser Ile Asp Ala Leu Gly Glu Ala 
    770                 775                 780                 


Ile Asn Glu Tyr Lys Gly Ala Val Ile Val Val Ser His Asp Ala Arg 
785                 790                 795                 800 


Leu Ile Thr Glu Thr Asn Cys Gln Leu Trp Val Val Glu Glu Gln Ser 
                805                 810                 815     


Val Ser Gln Ile Asp Gly Asp Phe Glu Asp Tyr Lys Arg Glu Val Leu 
            820                 825                 830         


Glu Ala Leu Gly Glu Val Met Val Ser Arg Pro Arg Glu 
        835                 840                 845 


<210>  134
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Solute carrier family 28 member 3 UniProt record number: Q9HAS3

<400>  134

Met Glu Leu Arg Ser Thr Ala Ala Pro Arg Ala Glu Gly Tyr Ser Asn 
1               5                   10                  15      


Val Gly Phe Gln Asn Glu Glu Asn Phe Leu Glu Asn Glu Asn Thr Ser 
            20                  25                  30          


Gly Asn Asn Ser Ile Arg Ser Arg Ala Val Gln Ser Arg Glu His Thr 
        35                  40                  45              


Asn Thr Lys Gln Asp Glu Glu Gln Val Thr Val Glu Gln Asp Ser Pro 
    50                  55                  60                  


Arg Asn Arg Glu His Met Glu Asp Asp Asp Glu Glu Met Gln Gln Lys 
65                  70                  75                  80  


Gly Cys Leu Glu Arg Arg Tyr Asp Thr Val Cys Gly Phe Cys Arg Lys 
                85                  90                  95      


His Lys Thr Thr Leu Arg His Ile Ile Trp Gly Ile Leu Leu Ala Gly 
            100                 105                 110         


Tyr Leu Val Met Val Ile Ser Ala Cys Val Leu Asn Phe His Arg Ala 
        115                 120                 125             


Leu Pro Leu Phe Val Ile Thr Val Ala Ala Ile Phe Phe Val Val Trp 
    130                 135                 140                 


Asp His Leu Met Ala Lys Tyr Glu His Arg Ile Asp Glu Met Leu Ser 
145                 150                 155                 160 


Pro Gly Arg Arg Leu Leu Asn Ser His Trp Phe Trp Leu Lys Trp Val 
                165                 170                 175     


Ile Trp Ser Ser Leu Val Leu Ala Val Ile Phe Trp Leu Ala Phe Asp 
            180                 185                 190         


Thr Ala Lys Leu Gly Gln Gln Gln Leu Val Ser Phe Gly Gly Leu Ile 
        195                 200                 205             


Met Tyr Ile Val Leu Leu Phe Leu Phe Ser Lys Tyr Pro Thr Arg Val 
    210                 215                 220                 


Tyr Trp Arg Pro Val Leu Trp Gly Ile Gly Leu Gln Phe Leu Leu Gly 
225                 230                 235                 240 


Leu Leu Ile Leu Arg Thr Asp Pro Gly Phe Ile Ala Phe Asp Trp Leu 
                245                 250                 255     


Gly Arg Gln Val Gln Thr Phe Leu Glu Tyr Thr Asp Ala Gly Ala Ser 
            260                 265                 270         


Phe Val Phe Gly Glu Lys Tyr Lys Asp His Phe Phe Ala Phe Lys Val 
        275                 280                 285             


Leu Pro Ile Val Val Phe Phe Ser Thr Val Met Ser Met Leu Tyr Tyr 
    290                 295                 300                 


Leu Gly Leu Met Gln Trp Ile Ile Arg Lys Val Gly Trp Ile Met Leu 
305                 310                 315                 320 


Val Thr Thr Gly Ser Ser Pro Ile Glu Ser Val Val Ala Ser Gly Asn 
                325                 330                 335     


Ile Phe Val Gly Gln Thr Glu Ser Pro Leu Leu Val Arg Pro Tyr Leu 
            340                 345                 350         


Pro Tyr Ile Thr Lys Ser Glu Leu His Ala Ile Met Thr Ala Gly Phe 
        355                 360                 365             


Ser Thr Ile Ala Gly Ser Val Leu Gly Ala Tyr Ile Ser Phe Gly Val 
    370                 375                 380                 


Pro Ser Ser His Leu Leu Thr Ala Ser Val Met Ser Ala Pro Ala Ser 
385                 390                 395                 400 


Leu Ala Ala Ala Lys Leu Phe Trp Pro Glu Thr Glu Lys Pro Lys Ile 
                405                 410                 415     


Thr Leu Lys Asn Ala Met Lys Met Glu Ser Gly Asp Ser Gly Asn Leu 
            420                 425                 430         


Leu Glu Ala Ala Thr Gln Gly Ala Ser Ser Ser Ile Ser Leu Val Ala 
        435                 440                 445             


Asn Ile Ala Val Asn Leu Ile Ala Phe Leu Ala Leu Leu Ser Phe Met 
    450                 455                 460                 


Asn Ser Ala Leu Ser Trp Phe Gly Asn Met Phe Asp Tyr Pro Gln Leu 
465                 470                 475                 480 


Ser Phe Glu Leu Ile Cys Ser Tyr Ile Phe Met Pro Phe Ser Phe Met 
                485                 490                 495     


Met Gly Val Glu Trp Gln Asp Ser Phe Met Val Ala Arg Leu Ile Gly 
            500                 505                 510         


Tyr Lys Thr Phe Phe Asn Glu Phe Val Ala Tyr Glu His Leu Ser Lys 
        515                 520                 525             


Trp Ile His Leu Arg Lys Glu Gly Gly Pro Lys Phe Val Asn Gly Val 
    530                 535                 540                 


Gln Gln Tyr Ile Ser Ile Arg Ser Glu Ile Ile Ala Thr Tyr Ala Leu 
545                 550                 555                 560 


Cys Gly Phe Ala Asn Ile Gly Ser Leu Gly Ile Val Ile Gly Gly Leu 
                565                 570                 575     


Thr Ser Met Ala Pro Ser Arg Lys Arg Asp Ile Ala Ser Gly Ala Val 
            580                 585                 590         


Arg Ala Leu Ile Ala Gly Thr Val Ala Cys Phe Met Thr Ala Cys Ile 
        595                 600                 605             


Ala Gly Ile Leu Ser Ser Thr Pro Val Asp Ile Asn Cys His His Val 
    610                 615                 620                 


Leu Glu Asn Ala Phe Asn Ser Thr Phe Pro Gly Asn Thr Thr Lys Val 
625                 630                 635                 640 


Ile Ala Cys Cys Gln Ser Leu Leu Ser Ser Thr Val Ala Lys Gly Pro 
                645                 650                 655     


Gly Glu Val Ile Pro Gly Gly Asn His Ser Leu Tyr Ser Leu Lys Gly 
            660                 665                 670         


Cys Cys Thr Leu Leu Asn Pro Ser Thr Phe Asn Cys Asn Gly Ile Ser 
        675                 680                 685             


Asn Thr Phe 
    690     


<210>  135
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATP-binding cassette sub-family B member 6, mito. UniProt record 
       number:	Q9NP58

<400>  135

Met Val Thr Val Gly Asn Tyr Cys Glu Ala Glu Gly Pro Val Gly Pro 
1               5                   10                  15      


Ala Trp Met Gln Asp Gly Leu Ser Pro Cys Phe Phe Phe Thr Leu Val 
            20                  25                  30          


Pro Ser Thr Arg Met Ala Leu Gly Thr Leu Ala Leu Val Leu Ala Leu 
        35                  40                  45              


Pro Cys Arg Arg Arg Glu Arg Pro Ala Gly Ala Asp Ser Leu Ser Trp 
    50                  55                  60                  


Gly Ala Gly Pro Arg Ile Ser Pro Tyr Val Leu Gln Leu Leu Leu Ala 
65                  70                  75                  80  


Thr Leu Gln Ala Ala Leu Pro Leu Ala Gly Leu Ala Gly Arg Val Gly 
                85                  90                  95      


Thr Ala Arg Gly Ala Pro Leu Pro Ser Tyr Leu Leu Leu Ala Ser Val 
            100                 105                 110         


Leu Glu Ser Leu Ala Gly Ala Cys Gly Leu Trp Leu Leu Val Val Glu 
        115                 120                 125             


Arg Ser Gln Ala Arg Gln Arg Leu Ala Met Gly Ile Trp Ile Lys Phe 
    130                 135                 140                 


Arg His Ser Pro Gly Leu Leu Leu Leu Trp Thr Val Ala Phe Ala Ala 
145                 150                 155                 160 


Glu Asn Leu Ala Leu Val Ser Trp Asn Ser Pro Gln Trp Trp Trp Ala 
                165                 170                 175     


Arg Ala Asp Leu Gly Gln Gln Val Gln Phe Ser Leu Trp Val Leu Arg 
            180                 185                 190         


Tyr Val Val Ser Gly Gly Leu Phe Val Leu Gly Leu Trp Ala Pro Gly 
        195                 200                 205             


Leu Arg Pro Gln Ser Tyr Thr Leu Gln Val His Glu Glu Asp Gln Asp 
    210                 215                 220                 


Val Glu Arg Ser Gln Val Arg Ser Ala Ala Gln Gln Ser Thr Trp Arg 
225                 230                 235                 240 


Asp Phe Gly Arg Lys Leu Arg Leu Leu Ser Gly Tyr Leu Trp Pro Arg 
                245                 250                 255     


Gly Ser Pro Ala Leu Gln Leu Val Val Leu Ile Cys Leu Gly Leu Met 
            260                 265                 270         


Gly Leu Glu Arg Ala Leu Asn Val Leu Val Pro Ile Phe Tyr Arg Asn 
        275                 280                 285             


Ile Val Asn Leu Leu Thr Glu Lys Ala Pro Trp Asn Ser Leu Ala Trp 
    290                 295                 300                 


Thr Val Thr Ser Tyr Val Phe Leu Lys Phe Leu Gln Gly Gly Gly Thr 
305                 310                 315                 320 


Gly Ser Thr Gly Phe Val Ser Asn Leu Arg Thr Phe Leu Trp Ile Arg 
                325                 330                 335     


Val Gln Gln Phe Thr Ser Arg Arg Val Glu Leu Leu Ile Phe Ser His 
            340                 345                 350         


Leu His Glu Leu Ser Leu Arg Trp His Leu Gly Arg Arg Thr Gly Glu 
        355                 360                 365             


Val Leu Arg Ile Ala Asp Arg Gly Thr Ser Ser Val Thr Gly Leu Leu 
    370                 375                 380                 


Ser Tyr Leu Val Phe Asn Val Ile Pro Thr Leu Ala Asp Ile Ile Ile 
385                 390                 395                 400 


Gly Ile Ile Tyr Phe Ser Met Phe Phe Asn Ala Trp Phe Gly Leu Ile 
                405                 410                 415     


Val Phe Leu Cys Met Ser Leu Tyr Leu Thr Leu Thr Ile Val Val Thr 
            420                 425                 430         


Glu Trp Arg Thr Lys Phe Arg Arg Ala Met Asn Thr Gln Glu Asn Ala 
        435                 440                 445             


Thr Arg Ala Arg Ala Val Asp Ser Leu Leu Asn Phe Glu Thr Val Lys 
    450                 455                 460                 


Tyr Tyr Asn Ala Glu Ser Tyr Glu Val Glu Arg Tyr Arg Glu Ala Ile 
465                 470                 475                 480 


Ile Lys Tyr Gln Gly Leu Glu Trp Lys Ser Ser Ala Ser Leu Val Leu 
                485                 490                 495     


Leu Asn Gln Thr Gln Asn Leu Val Ile Gly Leu Gly Leu Leu Ala Gly 
            500                 505                 510         


Ser Leu Leu Cys Ala Tyr Phe Val Thr Glu Gln Lys Leu Gln Val Gly 
        515                 520                 525             


Asp Tyr Val Leu Phe Gly Thr Tyr Ile Ile Gln Leu Tyr Met Pro Leu 
    530                 535                 540                 


Asn Trp Phe Gly Thr Tyr Tyr Arg Met Ile Gln Thr Asn Phe Ile Asp 
545                 550                 555                 560 


Met Glu Asn Met Phe Asp Leu Leu Lys Glu Glu Thr Glu Val Lys Asp 
                565                 570                 575     


Leu Pro Gly Ala Gly Pro Leu Arg Phe Gln Lys Gly Arg Ile Glu Phe 
            580                 585                 590         


Glu Asn Val His Phe Ser Tyr Ala Asp Gly Arg Glu Thr Leu Gln Asp 
        595                 600                 605             


Val Ser Phe Thr Val Met Pro Gly Gln Thr Leu Ala Leu Val Gly Pro 
    610                 615                 620                 


Ser Gly Ala Gly Lys Ser Thr Ile Leu Arg Leu Leu Phe Arg Phe Tyr 
625                 630                 635                 640 


Asp Ile Ser Ser Gly Cys Ile Arg Ile Asp Gly Gln Asp Ile Ser Gln 
                645                 650                 655     


Val Thr Gln Ala Ser Leu Arg Ser His Ile Gly Val Val Pro Gln Asp 
            660                 665                 670         


Thr Val Leu Phe Asn Asp Thr Ile Ala Asp Asn Ile Arg Tyr Gly Arg 
        675                 680                 685             


Val Thr Ala Gly Asn Asp Glu Val Glu Ala Ala Ala Gln Ala Ala Gly 
    690                 695                 700                 


Ile His Asp Ala Ile Met Ala Phe Pro Glu Gly Tyr Arg Thr Gln Val 
705                 710                 715                 720 


Gly Glu Arg Gly Leu Lys Leu Ser Gly Gly Glu Lys Gln Arg Val Ala 
                725                 730                 735     


Ile Ala Arg Thr Ile Leu Lys Ala Pro Gly Ile Ile Leu Leu Asp Glu 
            740                 745                 750         


Ala Thr Ser Ala Leu Asp Thr Ser Asn Glu Arg Ala Ile Gln Ala Ser 
        755                 760                 765             


Leu Ala Lys Val Cys Ala Asn Arg Thr Thr Ile Val Val Ala His Arg 
    770                 775                 780                 


Leu Ser Thr Val Val Asn Ala Asp Gln Ile Leu Val Ile Lys Asp Gly 
785                 790                 795                 800 


Cys Ile Val Glu Arg Gly Arg His Glu Ala Leu Leu Ser Arg Gly Gly 
                805                 810                 815     


Val Tyr Ala Asp Met Trp Gln Leu Gln Gln Gly Gln Glu Glu Thr Ser 
            820                 825                 830         


Glu Asp Thr Lys Pro Gln Thr Met Glu Arg 
        835                 840         


