                         SEQUENCE LISTING

<110>  Versameb AG
 
<120>  RNA encoding a protein

<130>  P5625PC00

<160>  193   

<170>  PatentIn version 3.5

<210>  1
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.1

<400>  1
atgggcaaga ttagcagcct gcctacacag ctgttcaagt gctgcttctg cgacttcctg       60

aaagtgaaga tgcacaccat gagcagcagc cacctgttct atctggccct gtgcctgctg      120

acctttacca gctctgctac cgccggacct gagacacttt gtggcgctga actggtggac      180

gccctgcagt ttgtgtgtgg cgacagaggc ttctacttca acaagcccac aggctacggc      240

agcagctcta gaagggctcc tcagaccgga atcgtggacg agtgctgttt cagaagctgc      300

gacctgcggc ggctggaaat gtattgtgcc cctctgaagc ctgccaagag cgcctaa         357


<210>  2
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.1


<210>  
<211>  modified_base
<212>  (1)..(357)
<213>  m1f (uridine is 1-methylpseudouridine)

<400>  2
augggcaaga uuagcagccu gccuacacag cuguucaagu gcugcuucug cgacuuccug       60

aaagugaaga ugcacaccau gagcagcagc caccuguucu aucuggcccu gugccugcug      120

accuuuacca gcucugcuac cgccggaccu gagacacuuu guggcgcuga acugguggac      180

gcccugcagu uugugugugg cgacagaggc uucuacuuca acaagcccac aggcuacggc      240

agcagcucua gaagggcucc ucagaccgga aucguggacg agugcuguuu cagaagcugc      300

gaccugcggc ggcuggaaau guauugugcc ccucugaagc cugccaagag cgccuaa         357


<210>  3
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.2

<400>  3
atgggaatac ctatgggcaa gagcatgctg gtgctgctga ccttcctggc cttcgcctct       60

tgttgtatcg ccgtgaagat gcacaccatg agcagcagcc acctgttcta tctggccctg      120

tgcctgctga cattcaccag ctctgctacc gccggacctg agacactttg tggcgctgaa      180

ctggtggacg ccctgcagtt tgtgtgtggc gacagaggct tctacttcaa caagcccaca      240

ggctacggca gcagctctag aagggctcct cagaccggaa tcgtggacga gtgctgcttc      300

agaagctgcg acctgcggcg gctggaaatg tattgtgccc ctctgaagcc tgccaagagc      360

gcctaa                                                                 366


<210>  4
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.2


<210>  
<211>  modified_base
<212>  (1)..(366)
<213>  m1f (uridine is 1-methylpseudouridine)

<400>  4
augggaauac cuaugggcaa gagcaugcug gugcugcuga ccuuccuggc cuucgccucu       60

uguuguaucg ccgugaagau gcacaccaug agcagcagcc accuguucua ucuggcccug      120

ugccugcuga cauucaccag cucugcuacc gccggaccug agacacuuug uggcgcugaa      180

cugguggacg cccugcaguu uguguguggc gacagaggcu ucuacuucaa caagcccaca      240

ggcuacggca gcagcucuag aagggcuccu cagaccggaa ucguggacga gugcugcuuc      300

agaagcugcg accugcggcg gcuggaaaug uauugugccc cucugaagcc ugccaagagc      360

gccuaa                                                                 366


<210>  5
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.3

<400>  5
atgaaatggg tcacctttat cagcctgctg ttcctgttca gcagcgccta cagcgtgaag       60

atgcacacca tgagcagcag ccacctgttc tatctggccc tgtgcctgct gaccttcaca      120

agctctgcta ccgccggacc tgagacactg tgtggtgctg aactggtgga cgccctgcag      180

ttcgtgtgtg gcgatagagg cttctacttc aacaagccca ccggctacgg cagcagctct      240

agaagggctc ctcagaccgg aatcgtggac gagtgctgct tcagaagctg cgacctgcgg      300

cggctggaaa tgtattgtgc ccctctgaag cctgccaaga gcgcctaa                   348


<210>  6
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.3


<210>  
<211>  modified_base
<212>  (1)..(348)
<213>  m1f (uridine is 1-methylpseudouridine)

<400>  6
augaaauggg ucaccuuuau cagccugcug uuccuguuca gcagcgccua cagcgugaag       60

augcacacca ugagcagcag ccaccuguuc uaucuggccc ugugccugcu gaccuucaca      120

agcucugcua ccgccggacc ugagacacug uguggugcug aacuggugga cgcccugcag      180

uucgugugug gcgauagagg cuucuacuuc aacaagccca ccggcuacgg cagcagcucu      240

agaagggcuc cucagaccgg aaucguggac gagugcugcu ucagaagcug cgaccugcgg      300

cggcuggaaa uguauugugc cccucugaag ccugccaaga gcgccuaa                   348


<210>  7
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.4

<400>  7
atgaccatcc tgtttctgac aatggtcatc agctacttcg gctgcatgaa ggccgtgaag       60

atgcacacca tgagcagcag ccacctgttc tatctggccc tgtgcctgct gacctttacc      120

agctctgcta ccgccggacc tgagacactt tgtggcgctg aactggtgga cgccctgcag      180

tttgtgtgtg gcgacagagg cttctacttc aacaagccca caggctacgg cagcagctct      240

agaagggctc ctcagaccgg aatcgtggac gagtgctgct tcagaagctg cgacctgcgg      300

cggctggaaa tgtattgtgc ccctctgaag cctgccaaga gcgcctaa                   348


<210>  8
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.4


<210>  
<211>  modified_base
<212>  (1)..(348)
<213>  m1f (uridine is 1-methylpseudouridine)

<400>  8
augaccaucc uguuucugac aauggucauc agcuacuucg gcugcaugaa ggccgugaag       60

augcacacca ugagcagcag ccaccuguuc uaucuggccc ugugccugcu gaccuuuacc      120

agcucugcua ccgccggacc ugagacacuu uguggcgcug aacuggugga cgcccugcag      180

uuugugugug gcgacagagg cuucuacuuc aacaagccca caggcuacgg cagcagcucu      240

agaagggcuc cucagaccgg aaucguggac gagugcugcu ucagaagcug cgaccugcgg      300

cggcuggaaa uguauugugc cccucugaag ccugccaaga gcgccuaa                   348


<210>  9
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.5

<400>  9
atgaatgcca aagtggtggt ggtgctggtc ctggtgctga cagctctgtg tctgtccgac       60

ggcgtgaaga tgcacaccat gagcagcagc cacctgttct atctggccct gtgcctgctg      120

acctttacca gctctgctac cgccggacct gagacacttt gtggcgctga actggtggac      180

gccctgcagt ttgtgtgtgg cgacagaggc ttctacttca acaagcccac aggctacggc      240

agcagctcta gaagggctcc tcagaccgga atcgtggacg agtgctgctt cagaagctgc      300

gacctgcggc ggctggaaat gtattgtgcc cctctgaagc ctgccaagag cgcctaa         357


<210>  10
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.5

<210>  
<211>  modified_base
<212>  (1)..(357)
<213>  m1f (uridine is 1-methylpseudouridine)

<400>  10
augaaugcca aagugguggu ggugcugguc cuggugcuga cagcucugug ucuguccgac       60

ggcgugaaga ugcacaccau gagcagcagc caccuguucu aucuggcccu gugccugcug      120

accuuuacca gcucugcuac cgccggaccu gagacacuuu guggcgcuga acugguggac      180

gcccugcagu uugugugugg cgacagaggc uucuacuuca acaagcccac aggcuacggc      240

agcagcucua gaagggcucc ucagaccgga aucguggacg agugcugcuu cagaagcugc      300

gaccugcggc ggcuggaaau guauugugcc ccucugaagc cugccaagag cgccuaa         357


<210>  11
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.6

<400>  11
atgggctggt cctgcatcat cctgtttctg gtggccacag ccacaggcgt gcacagcgtg       60

aagatgcaca caatgagcag cagccacctg ttctatctgg ccctgtgcct gctgaccttt      120

accagctctg ctaccgccgg acctgagaca ctttgtggcg ctgaactggt ggacgccctg      180

cagtttgtgt gtggcgacag aggcttctac ttcaacaagc ccacaggcta cggcagcagc      240

tctagaaggg ctcctcagac cggaatcgtg gacgagtgct gcttcagaag ctgcgacctg      300

cggcggctgg aaatgtattg tgcccctctg aagcctgcca agagcgccta a               351


<210>  12
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.6


<210>  
<211>  modified_base
<212>  (1)..(351)
<213>  m1f (uridine is 1-methylpseudouridine)

<400>  12
augggcuggu ccugcaucau ccuguuucug guggccacag ccacaggcgu gcacagcgug       60

aagaugcaca caaugagcag cagccaccug uucuaucugg cccugugccu gcugaccuuu      120

accagcucug cuaccgccgg accugagaca cuuuguggcg cugaacuggu ggacgcccug      180

caguuugugu guggcgacag aggcuucuac uucaacaagc ccacaggcua cggcagcagc      240

ucuagaaggg cuccucagac cggaaucgug gacgagugcu gcuucagaag cugcgaccug      300

cggcggcugg aaauguauug ugccccucug aagccugcca agagcgccua a               351


<210>  13
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.7

<400>  13
atggactgga cttggagaat cctgttcctg gtggccgctg ccacaggcgc ccattctgtg       60

aagatgcaca ccatgagcag cagccacctg ttctatctgg ccctgtgcct gctgaccttt      120

accagctctg ctaccgccgg acctgagaca ctttgtggcg ctgaactggt ggacgccctg      180

cagtttgtgt gtggcgacag aggcttctac ttcaacaagc ccacaggcta cggcagcagc      240

tctagaaggg ctcctcagac cggaatcgtg gacgagtgct gcttcagaag ctgcgacctg      300

cggcggctgg aaatgtattg tgcccctctg aagcctgcca agagcgccta a               351


<210>  14
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.7


<210>  
<211>  modified_base
<212>  (1)..(351)
<213>  m1f (uridine is 1-methylpseudouridine)

<400>  14
auggacugga cuuggagaau ccuguuccug guggccgcug ccacaggcgc ccauucugug       60

aagaugcaca ccaugagcag cagccaccug uucuaucugg cccugugccu gcugaccuuu      120

accagcucug cuaccgccgg accugagaca cuuuguggcg cugaacuggu ggacgcccug      180

caguuugugu guggcgacag aggcuucuac uucaacaagc ccacaggcua cggcagcagc      240

ucuagaaggg cuccucagac cggaaucgug gacgagugcu gcuucagaag cugcgaccug      300

cggcggcugg aaauguauug ugccccucug aagccugcca agagcgccua a               351


<210>  15
<211>  3450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector pVAX.A120 with Cpd.1

<400>  15
gactcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catgggcaag attagcagcc tgcctacaca gctgttcaag      780

tgctgcttct gcgacttcct gaaagtgaag atgcacacca tgagcagcag ccacctgttc      840

tatctggccc tgtgcctgct gacctttacc agctctgcta ccgccggacc tgagacactt      900

tgtggcgctg aactggtgga cgccctgcag tttgtgtgtg gcgacagagg cttctacttc      960

aacaagccca caggctacgg cagcagctct agaagggctc ctcagaccgg aatcgtggac     1020

gagtgctgtt tcagaagctg cgacctgcgg cggctggaaa tgtattgtgc ccctctgaag     1080

cctgccaaga gcgcctaaga attctgcaga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaag cggccgctcg agtctagagg gcccgtttaa     1260

acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     1320

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     1380

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     1440

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct     1500

atggcttcta ctgggcggtt ttatggacag caagcgaacc ggaattgcca gctggggcgc     1560

cctctggtaa ggttgggaag ccctgcaaag taaactggat ggctttctcg ccgccaagga     1620

tctgatggcg caggggatca agctctgatc aagagacagg atgaggatcg tttcgcatga     1680

ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg ctattcggct     1740

atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc     1800

aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat gaactgcaag     1860

acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca gctgtgctcg     1920

acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg gggcaggatc     1980

tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat gcaatgcggc     2040

ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa catcgcatcg     2100

agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg gacgaagagc     2160

atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgagcatg cccgacggcg     2220

aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc     2280

gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag     2340

cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg     2400

tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg     2460

agttcttctg aattattaac gcttacaatt tcctgatgcg gtattttctc cttacgcatc     2520

tgtgcggtat ttcacaccgc atacaggtgg cacttttcgg ggaaatgtgc gcggaacccc     2580

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     2640

ataaatgctt caataatagc acgtgctaaa acttcatttt taatttaaaa ggatctaggt     2700

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     2760

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     2820

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     2880

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     2940

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     3000

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     3060

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     3120

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     3180

gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     3240

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     3300

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     3360

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggg     3420

cttttgctgg ccttttgctc acatgttctt                                      3450


<210>  16
<211>  2758
<212>  DNA
<213>  Artificial Sequence

<220>

<223>  DNA sequence of vector pMA-T with Cpd.2

<400>  16
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcggatc cgccaccatg ggaataccta tgggcaagag      420

catgctggtg ctgctgacct tcctggcctt cgcctcttgt tgtatcgccg tgaagatgca      480

caccatgagc agcagccacc tgttctatct ggccctgtgc ctgctgacat tcaccagctc      540

tgctaccgcc ggacctgaga cactttgtgg cgctgaactg gtggacgccc tgcagtttgt      600

gtgtggcgac agaggcttct acttcaacaa gcccacaggc tacggcagca gctctagaag      660

ggctcctcag accggaatcg tggacgagtg ctgcttcaga agctgcgacc tgcggcggct      720

ggaaatgtat tgtgcccctc tgaagcctgc caagagcgcc taagaattcg gtacctggag      780

cacaagactg gcctcatggg ccttccgctc actgcccgct ttccagtcgg gaaacctgtc      840

gtgccagctg cattaacatg gtcatagctg tttccttgcg tattgggcgc tctccgcttc      900

ctcgctcact gactcgctgc gctcggtcgt tcgggtaaag cctggggtgc ctaatgagca      960

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg     1020

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg     1080

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt     1140

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt     1200

tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc     1260

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt     1320

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt     1380

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc     1440

tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa     1500

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt     1560

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct     1620

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta     1680

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa     1740

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc     1800

tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact     1860

acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg agaaccacgc     1920

tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt     1980

ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta     2040

agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg     2100

tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt     2160

acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc     2220

agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt     2280

actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc     2340

tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc     2400

gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa     2460

ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac     2520

tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa     2580

aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt     2640

tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa     2700

tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccac       2758


<210>  17
<211>  2740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector pMA-T with Cpd.3

<400>  17
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcggatc cgccaccatg aaatgggtca cctttatcag      420

cctgctgttc ctgttcagca gcgcctacag cgtgaagatg cacaccatga gcagcagcca      480

cctgttctat ctggccctgt gcctgctgac cttcacaagc tctgctaccg ccggacctga      540

gacactgtgt ggtgctgaac tggtggacgc cctgcagttc gtgtgtggcg atagaggctt      600

ctacttcaac aagcccaccg gctacggcag cagctctaga agggctcctc agaccggaat      660

cgtggacgag tgctgcttca gaagctgcga cctgcggcgg ctggaaatgt attgtgcccc      720

tctgaagcct gccaagagcg cctaagaatt cggtacctgg agcacaagac tggcctcatg      780

ggccttccgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaaca      840

tggtcatagc tgtttccttg cgtattgggc gctctccgct tcctcgctca ctgactcgct      900

gcgctcggtc gttcgggtaa agcctggggt gcctaatgag caaaaggcca gcaaaaggcc      960

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     1020

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     1080

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     1140

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     1200

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     1260

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     1320

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     1380

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta     1440

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     1500

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     1560

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     1620

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     1680

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     1740

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     1800

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     1860

ccatctggcc ccagtgctgc aatgataccg cgagaaccac gctcaccggc tccagattta     1920

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     1980

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     2040

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     2100

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     2160

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     2220

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     2280

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     2340

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     2400

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     2460

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     2520

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2580

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2640

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     2700

caaatagggg ttccgcgcac atttccccga aaagtgccac                           2740


<210>  18
<211>  2740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector pMA-T with Cpd.4

<400>  18
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcggatc cgccaccatg accatcctgt ttctgacaat      420

ggtcatcagc tacttcggct gcatgaaggc cgtgaagatg cacaccatga gcagcagcca      480

cctgttctat ctggccctgt gcctgctgac ctttaccagc tctgctaccg ccggacctga      540

gacactttgt ggcgctgaac tggtggacgc cctgcagttt gtgtgtggcg acagaggctt      600

ctacttcaac aagcccacag gctacggcag cagctctaga agggctcctc agaccggaat      660

cgtggacgag tgctgcttca gaagctgcga cctgcggcgg ctggaaatgt attgtgcccc      720

tctgaagcct gccaagagcg cctaagaatt cggtacctgg agcacaagac tggcctcatg      780

ggccttccgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaaca      840

tggtcatagc tgtttccttg cgtattgggc gctctccgct tcctcgctca ctgactcgct      900

gcgctcggtc gttcgggtaa agcctggggt gcctaatgag caaaaggcca gcaaaaggcc      960

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     1020

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     1080

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     1140

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     1200

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     1260

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     1320

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     1380

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta     1440

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     1500

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     1560

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     1620

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     1680

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     1740

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     1800

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     1860

ccatctggcc ccagtgctgc aatgataccg cgagaaccac gctcaccggc tccagattta     1920

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     1980

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     2040

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     2100

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     2160

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     2220

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     2280

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     2340

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     2400

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     2460

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     2520

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2580

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2640

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     2700

caaatagggg ttccgcgcac atttccccga aaagtgccac                           2740


<210>  19
<211>  2749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector pMA-T with Cpd.5

<400>  19
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcggatc cgccaccatg aatgccaaag tggtggtggt      420

gctggtcctg gtgctgacag ctctgtgtct gtccgacggc gtgaagatgc acaccatgag      480

cagcagccac ctgttctatc tggccctgtg cctgctgacc tttaccagct ctgctaccgc      540

cggacctgag acactttgtg gcgctgaact ggtggacgcc ctgcagtttg tgtgtggcga      600

cagaggcttc tacttcaaca agcccacagg ctacggcagc agctctagaa gggctcctca      660

gaccggaatc gtggacgagt gctgcttcag aagctgcgac ctgcggcggc tggaaatgta      720

ttgtgcccct ctgaagcctg ccaagagcgc ctaagaattc ggtacctgga gcacaagact      780

ggcctcatgg gccttccgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct      840

gcattaacat ggtcatagct gtttccttgc gtattgggcg ctctccgctt cctcgctcac      900

tgactcgctg cgctcggtcg ttcgggtaaa gcctggggtg cctaatgagc aaaaggccag      960

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     1020

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     1080

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     1140

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     1200

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     1260

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     1320

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     1380

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     1440

agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     1500

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     1560

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     1620

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     1680

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     1740

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     1800

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     1860

gagggcttac catctggccc cagtgctgca atgataccgc gagaaccacg ctcaccggct     1920

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     1980

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg     2040

ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg     2100

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc     2160

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag     2220

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg     2280

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag     2340

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat     2400

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg     2460

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca     2520

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca     2580

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat     2640

tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag     2700

aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccac                 2749


<210>  20
<211>  2710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector pMA-RQ with Cpd.6

<400>  20
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg gatccgccac catgggctgg tcctgcatca tcctgtttct ggtggccaca      420

gccacaggcg tgcacagcgt gaagatgcac acaatgagca gcagccacct gttctatctg      480

gccctgtgcc tgctgacctt taccagctct gctaccgccg gacctgagac actttgtggc      540

gctgaactgg tggacgccct gcagtttgtg tgtggcgaca gaggcttcta cttcaacaag      600

cccacaggct acggcagcag ctctagaagg gctcctcaga ccggaatcgt ggacgagtgc      660

tgcttcagaa gctgcgacct gcggcggctg gaaatgtatt gtgcccctct gaagcctgcc      720

aagagcgcct aagaattcct gggcctcatg ggccttccgc tcactgcccg ctttccagtc      780

gggaaacctg tcgtgccagc tgcattaaca tggtcatagc tgtttccttg cgtattgggc      840

gctctccgct tcctcgctca ctgactcgct gcgctcggtc gttcgggtaa agcctggggt      900

gcctaatgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg      960

tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg     1020

tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg     1080

cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga     1140

agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc     1200

tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt     1260

aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact     1320

ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg     1380

cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt     1440

accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt     1500

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct     1560

ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg     1620

gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt     1680

aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt     1740

gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc     1800

gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg     1860

cgagaaccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc     1920

gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg     1980

gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca     2040

ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga     2100

tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct     2160

ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg     2220

cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca     2280

accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata     2340

cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct     2400

tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact     2460

cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa     2520

acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc     2580

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga     2640

tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga     2700

aaagtgccac                                                            2710


<210>  21
<211>  2710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector pMA-RQ with Cpd.7

<400>  21
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg gatccgccac catggactgg acttggagaa tcctgttcct ggtggccgct      420

gccacaggcg cccattctgt gaagatgcac accatgagca gcagccacct gttctatctg      480

gccctgtgcc tgctgacctt taccagctct gctaccgccg gacctgagac actttgtggc      540

gctgaactgg tggacgccct gcagtttgtg tgtggcgaca gaggcttcta cttcaacaag      600

cccacaggct acggcagcag ctctagaagg gctcctcaga ccggaatcgt ggacgagtgc      660

tgcttcagaa gctgcgacct gcggcggctg gaaatgtatt gtgcccctct gaagcctgcc      720

aagagcgcct aagaattcct gggcctcatg ggccttccgc tcactgcccg ctttccagtc      780

gggaaacctg tcgtgccagc tgcattaaca tggtcatagc tgtttccttg cgtattgggc      840

gctctccgct tcctcgctca ctgactcgct gcgctcggtc gttcgggtaa agcctggggt      900

gcctaatgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg      960

tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg     1020

tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg     1080

cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga     1140

agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc     1200

tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt     1260

aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact     1320

ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg     1380

cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt     1440

accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt     1500

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct     1560

ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg     1620

gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt     1680

aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt     1740

gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc     1800

gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg     1860

cgagaaccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc     1920

gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg     1980

gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca     2040

ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga     2100

tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct     2160

ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg     2220

cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca     2280

accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata     2340

cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct     2400

tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact     2460

cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa     2520

acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc     2580

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga     2640

tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga     2700

aaagtgccac                                                            2710


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Primer

<400>  22
gctgcaaggc gattaagttg                                                   20


<210>  23
<211>  140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Primer


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  um

<400>  23
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttcag      120

ctatgaccat gttaatgcag                                                  140


<210>  24
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGF1 signal peptide

<400>  24
atgggcaaga ttagcagcct gcctacacag ctgttcaagt gctgcttctg cgacttcctg       60

aaa                                                                     63


<210>  25
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys 
            20      


<210>  26
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGF2 signal peptide


<400>  26
atgggaatac ctatgggcaa gagcatgctg gtgctgctga ccttcctggc cttcgcctct       60

tgttgtatcg cc                                                           72


<210>  27
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala 
            20                  


<210>  28
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223> ALB signal peptide

<400>  28
atgaaatggg tcacctttat cagcctgctg ttcctgttca gcagcgccta cagc             54


<210>  29
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  30
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BDNF signal peptide

<400>  30
atgaccatcc tgtttctgac aatggtcatc agctacttcg gctgcatgaa ggcc             54


<210>  31
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala 
        


<210>  32
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL12 signal peptide


<400>  32
atgaatgcca aagtggtggt ggtgctggtc ctggtgctga cagctctgtg tctgtccgac       60

ggc                                                                     63


<210>  33
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly 
            20      


<210>  34
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SEQ1 signal peptide

<400>  34
atgggctggt cctgcatcat cctgtttctg gtggccacag ccacaggcgt gcacagc          57


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SEQ1 signal peptide

<400>  35

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  36
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic SEQ2 signal peptide

<400>  36
atggactgga cttggagaat cctgttcctg gtggccgctg ccacaggcgc ccattct          57


<210>  37
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic SEQ2 signal peptide

<400>  37

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  38
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Propeptide of human IGF1

<400>  38
gtgaagatgc acaccatgag cagcagccac ctgttctatc tggccctgtg cctgctgacc       60

tttaccagct ctgctaccgc c                                                 81


<210>  39
<211>  210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mature human IGF1


<400>  39
ggacctgaga cactttgtgg cgctgaactg gtggacgccc tgcagtttgt gtgtggcgac       60

agaggcttct acttcaacaa gcccacaggc tacggcagca gctctagaag ggctcctcag      120

accggaatcg tggacgagtg ctgtttcaga agctgcgacc tgcggcggct ggaaatgtat      180

tgtgcccctc tgaagcctgc caagagcgcc                                       210


<210>  40
<211>  2749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequcence of vector_pMA-T with compound 1

<400>  40
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcggatc cgccaccatg ggcaagatta gcagcctgcc      420

tacacagctg ttcaagtgct gcttctgcga cttcctgaaa gtgaagatgc acaccatgag      480

cagcagccac ctgttctatc tggccctgtg cctgctgacc tttaccagct ctgctaccgc      540

cggacctgag acactttgtg gcgctgaact ggtggacgcc ctgcagtttg tgtgtggcga      600

cagaggcttc tacttcaaca agcccacagg ctacggcagc agctctagaa gggctcctca      660

gaccggaatc gtggacgagt gctgtttcag aagctgcgac ctgcggcggc tggaaatgta      720

ttgtgcccct ctgaagcctg ccaagagcgc ctaagaattc ggtacctgga gcacaagact      780

ggcctcatgg gccttccgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct      840

gcattaacat ggtcatagct gtttccttgc gtattgggcg ctctccgctt cctcgctcac      900

tgactcgctg cgctcggtcg ttcgggtaaa gcctggggtg cctaatgagc aaaaggccag      960

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     1020

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     1080

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     1140

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     1200

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     1260

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     1320

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     1380

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     1440

agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     1500

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     1560

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     1620

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     1680

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     1740

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     1800

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     1860

gagggcttac catctggccc cagtgctgca atgataccgc gagaaccacg ctcaccggct     1920

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     1980

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg     2040

ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg     2100

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc     2160

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag     2220

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg     2280

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag     2340

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat     2400

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg     2460

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca     2520

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca     2580

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat     2640

tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag     2700

aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccac                 2749


<210>  41
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Arg Pro Arg Thr Lys Ala Arg Ser Pro Gly Arg Ala Leu Arg Asn 
1               5                   10                  15      


Pro Trp Arg Gly Phe Leu Pro Leu Thr Leu Ala Leu Phe Val Gly Ala 
            20                  25                  30          


Gly His Ala 
        35  


<210>  42
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LTBP2 SP

<400>  42
atgcggccca ggaccaaagc cagatctcct ggcagagccc tgcggaatcc ttggagagga       60

ttcctgcctc tgacactggc cctgtttgtt ggagccggac acgcc                      105


<210>  43
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.08

<400>  43
atgcggccca ggaccaaagc cagatctcct ggcagagccc tgcggaatcc ttggagagga       60

ttcctgcctc tgacactggc cctgtttgtt ggagccggac acgccgtgaa gatgcacaca      120

atgagcagca gccacctgtt ctacctggct ctgtgcctgc tgacctttac cagctctgcc      180

acagccggac ctgagacact ttgtggcgct gaactggtgg acgccctgca gtttgtgtgt      240

ggcgacagag gcttctactt caacaagccc acaggctacg gcagcagctc tagaagggct      300

cctcagaccg gaatcgtgga cgagtgctgc ttcagaagct gcgacctgcg gcggctggaa      360

atgtattgtg cccctctgaa gcctgccaag agcgcctaa                             399


<210>  44
<211>  399
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.08


<220>
<221>  modified_base
<222>  (1)..(399)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  44
augcggccca ggaccaaagc cagaucuccu ggcagagccc ugcggaaucc uuggagagga       60

uuccugccuc ugacacuggc ccuguuuguu ggagccggac acgccgugaa gaugcacaca      120

augagcagca gccaccuguu cuaccuggcu cugugccugc ugaccuuuac cagcucugcc      180

acagccggac cugagacacu uuguggcgcu gaacuggugg acgcccugca guuugugugu      240

ggcgacagag gcuucuacuu caacaagccc acaggcuacg gcagcagcuc uagaagggcu      300

ccucagaccg gaaucgugga cgagugcugc uucagaagcu gcgaccugcg gcggcuggaa      360

auguauugug ccccucugaa gccugccaag agcgccuaa                             399


<210>  45
<211>  2859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.08

<400>  45
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg gatcctatca tccctttgaa tggaagcctc cgtaaaacga cggccagtta      420

atacgactca ctatagggcc accatgcggc ccaggaccaa agccagatct cctggcagag      480

ccctgcggaa tccttggaga ggattcctgc ctctgacact ggccctgttt gttggagccg      540

gacacgccgt gaagatgcac acaatgagca gcagccacct gttctacctg gctctgtgcc      600

tgctgacctt taccagctct gccacagccg gacctgagac actttgtggc gctgaactgg      660

tggacgccct gcagtttgtg tgtggcgaca gaggcttcta cttcaacaag cccacaggct      720

acggcagcag ctctagaagg gctcctcaga ccggaatcgt ggacgagtgc tgcttcagaa      780

gctgcgacct gcggcggctg gaaatgtatt gtgcccctct gaagcctgcc aagagcgcct      840

aacaggaaac agctatgacg caaagcgttg agagtggtaa cgaattcctg ggcctcatgg      900

gccttccgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaacat      960

ggtcatagct gtttccttgc gtattgggcg ctctccgctt cctcgctcac tgactcgctg     1020

cgctcggtcg ttcgggtaaa gcctggggtg cctaatgagc aaaaggccag caaaaggcca     1080

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     1140

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     1200

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     1260

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta     1320

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     1380

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     1440

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     1500

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat     1560

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat     1620

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc     1680

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt     1740

ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct     1800

agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt     1860

ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc     1920

gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac     1980

catctggccc cagtgctgca atgataccgc gagaaccacg ctcaccggct ccagatttat     2040

cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg     2100

cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata     2160

gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta     2220

tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt     2280

gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag     2340

tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa     2400

gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc     2460

gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt     2520

taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc     2580

tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta     2640

ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa     2700

taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca     2760

tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac     2820

aaataggggt tccgcgcaca tttccccgaa aagtgccac                            2859


<210>  46
<211>  27
<212>  PRT
<213>  Homo sapiens
4
<400>  46

Met Ala Leu Arg Lys Gly Gly Leu Ala Leu Ala Leu Leu Leu Leu Ser 
1               5                   10                  15      


Trp Val Ala Leu Gly Pro Arg Ser Leu Glu Gly 
            20                  25          


<210>  47
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGFALS SP

<400>  47
atggctctgc ggaaaggtgg acttgctctg gctctgctgc tgctgtcttg ggttgcactg       60

ggccctagat ctctggaagg c                                                 81


<210>  48
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.09

<400>  48
atggctctgc ggaaaggtgg acttgctctg gctctgctgc tgctgtcttg ggttgcactg       60

ggccctagat ctctggaagg cgtgaagatg cacaccatga gcagcagcca cctgttctat      120

ctggccctgt gcctgctgac ctttaccagc tctgctaccg ccggacctga gacactttgt      180

ggcgctgaac tggtggacgc cctgcagttt gtgtgtggcg acagaggctt ctacttcaac      240

aagcccacag gctacggcag cagctctaga agggctcctc agaccggaat cgtggacgag      300

tgctgcttca gaagctgcga cctgcggcgg ctggaaatgt attgtgcccc tctgaagcct      360

gccaagagcg cctaa                                                       375


<210>  49
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.09


<220>
<221>  modified_base
<222>  (1)..(375)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  49
auggcucugc ggaaaggugg acuugcucug gcucugcugc ugcugucuug gguugcacug       60

ggcccuagau cucuggaagg cgugaagaug cacaccauga gcagcagcca ccuguucuau      120

cuggcccugu gccugcugac cuuuaccagc ucugcuaccg ccggaccuga gacacuuugu      180

ggcgcugaac ugguggacgc ccugcaguuu guguguggcg acagaggcuu cuacuucaac      240

aagcccacag gcuacggcag cagcucuaga agggcuccuc agaccggaau cguggacgag      300

ugcugcuuca gaagcugcga ccugcggcgg cuggaaaugu auugugcccc ucugaagccu      360

gccaagagcg ccuaa                                                       375


<210>  50
<211>  2835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA sequence of vector_ pMA-RQ with Cpd.9

<400>  50
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg gatcctatca tccctttgaa tggaagcctc cgtaaaacga cggccagtta      420

atacgactca ctatagggcc accatggctc tgcggaaagg tggacttgct ctggctctgc      480

tgctgctgtc ttgggttgca ctgggcccta gatctctgga aggcgtgaag atgcacacca      540

tgagcagcag ccacctgttc tatctggccc tgtgcctgct gacctttacc agctctgcta      600

ccgccggacc tgagacactt tgtggcgctg aactggtgga cgccctgcag tttgtgtgtg      660

gcgacagagg cttctacttc aacaagccca caggctacgg cagcagctct agaagggctc      720

ctcagaccgg aatcgtggac gagtgctgct tcagaagctg cgacctgcgg cggctggaaa      780

tgtattgtgc ccctctgaag cctgccaaga gcgcctaaca ggaaacagct atgacgcaaa      840

gcgttgagag tggtaacgaa ttcctgggcc tcatgggcct tccgctcact gcccgctttc      900

cagtcgggaa acctgtcgtg ccagctgcat taacatggtc atagctgttt ccttgcgtat      960

tgggcgctct ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg ggtaaagcct     1020

ggggtgccta atgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     1080

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     1140

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     1200

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     1260

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     1320

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     1380

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     1440

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     1500

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc     1560

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     1620

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     1680

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     1740

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     1800

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     1860

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc     1920

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga     1980

taccgcgaga accacgctca ccggctccag atttatcagc aataaaccag ccagccggaa     2040

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt     2100

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg     2160

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc     2220

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg     2280

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag     2340

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt     2400

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt     2460

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac     2520

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac     2580

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag     2640

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa     2700

tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga     2760

gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc     2820

cccgaaaagt gccac                                                      2835


<210>  51
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala 
            20                  


<210>  52
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INS SP

<400>  52
atggctctgt ggatgagact gctgcctctg ctggcactgc ttgctctgtg gggacctgat       60

cctgccgccg ct                                                           72


<210>  53
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.10

<400>  53
atggctctgt ggatgagact gctgcctctg ctggcactgc ttgctctgtg gggacctgat       60

cctgccgccg ctgtgaagat gcacacaatg agcagcagcc acctgttcta tctggccctg      120

tgcctgctga cctttaccag ctctgctacc gccggacctg agacactttg tggcgctgaa      180

ctggtggacg ccctgcagtt tgtgtgtggc gacagaggct tctacttcaa caagcccaca      240

ggctacggca gcagctctag aagggctcct cagaccggaa tcgtggacga gtgctgcttc      300

agaagctgcg acctgcggcg gctggaaatg tattgtgccc ctctgaagcc tgccaagagc      360

gcctaa                                                                 366


<210>  54
<211>  366
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.10


<220>
<221>  modified_base
<222>  (1)..(366)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  54
auggcucugu ggaugagacu gcugccucug cuggcacugc uugcucugug gggaccugau       60

ccugccgccg cugugaagau gcacacaaug agcagcagcc accuguucua ucuggcccug      120

ugccugcuga ccuuuaccag cucugcuacc gccggaccug agacacuuug uggcgcugaa      180

cugguggacg cccugcaguu uguguguggc gacagaggcu ucuacuucaa caagcccaca      240

ggcuacggca gcagcucuag aagggcuccu cagaccggaa ucguggacga gugcugcuuc      300

agaagcugcg accugcggcg gcuggaaaug uauugugccc cucugaagcc ugccaagagc      360

gccuaa                                                                 366


<210>  55
<211>  2713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.10

<400>  55
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatggc tctgtggatg agactgctgc ctctgctggc actgcttgct      420

ctgtggggac ctgatcctgc cgccgctgtg aagatgcaca caatgagcag cagccacctg      480

ttctatctgg ccctgtgcct gctgaccttt accagctctg ctaccgccgg acctgagaca      540

ctttgtggcg ctgaactggt ggacgccctg cagtttgtgt gtggcgacag aggcttctac      600

ttcaacaagc ccacaggcta cggcagcagc tctagaaggg ctcctcagac cggaatcgtg      660

gacgagtgct gcttcagaag ctgcgacctg cggcggctgg aaatgtattg tgcccctctg      720

aagcctgcca agagcgccta actgggcctc atgggccttc cgctcactgc ccgctttcca      780

gtcgggaaac ctgtcgtgcc agctgcatta acatggtcat agctgtttcc ttgcgtattg      840

ggcgctctcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggg taaagcctgg      900

ggtgcctaat gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg      960

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     1020

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     1080

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     1140

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     1200

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     1260

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     1320

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     1380

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     1440

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     1500

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     1560

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     1620

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     1680

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     1740

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc     1800

gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata     1860

ccgcgagaac cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg     1920

gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc     1980

cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct     2040

acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa     2100

cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt     2160

cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca     2220

ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac     2280

tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca     2340

atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt     2400

tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc     2460

actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca     2520

aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata     2580

ctcatactct tcctttttca atattattga agcatttatc agggttattg tctcatgagc     2640

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc     2700

cgaaaagtgc cac                                                        2713


<210>  56
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Pro Leu Gly Leu Pro Val Leu Gly 
            20                  25          


<210>  57
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Epo SP

<400>  57
atgggagtgc atgaatgtcc tgcttggctg tggctgctgc tgagcctgct gtctctgcct       60

ctgggactgc ctgtgctggg a                                                 81


<210>  58
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.11

<400>  58
atgggagtgc atgaatgtcc tgcttggctg tggctgctgc tgagcctgct gtctctgcct       60

ctgggactgc ctgtgctggg agtgaagatg cacaccatga gcagctccca cctgttctat      120

ctggccctgt gcctgctgac ctttaccagc tctgctaccg ccggacctga gacactttgt      180

ggcgctgaac tggtggacgc cctgcagttt gtgtgtggcg acagaggctt ctacttcaac      240

aagcccacag gctacggcag cagctctaga agggctcctc agaccggaat cgtggacgag      300

tgctgcttca gaagctgcga cctgcggcgg ctggaaatgt attgtgcccc tctgaagcct      360

gccaagagcg cctaa                                                       375


<210>  59
<211>  375
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.11


<220>
<221>  modified_base
<222>  (1)..(375)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  59
augggagugc augaaugucc ugcuuggcug uggcugcugc ugagccugcu gucucugccu       60

cugggacugc cugugcuggg agugaagaug cacaccauga gcagcuccca ccuguucuau      120

cuggcccugu gccugcugac cuuuaccagc ucugcuaccg ccggaccuga gacacuuugu      180

ggcgcugaac ugguggacgc ccugcaguuu guguguggcg acagaggcuu cuacuucaac      240

aagcccacag gcuacggcag cagcucuaga agggcuccuc agaccggaau cguggacgag      300

ugcugcuuca gaagcugcga ccugcggcgg cuggaaaugu auugugcccc ucugaagccu      360

gccaagagcg ccuaa                                                       375


<210>  60
<211>  2722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.11

<400>  60
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatggg agtgcatgaa tgtcctgctt ggctgtggct gctgctgagc      420

ctgctgtctc tgcctctggg actgcctgtg ctgggagtga agatgcacac catgagcagc      480

tcccacctgt tctatctggc cctgtgcctg ctgaccttta ccagctctgc taccgccgga      540

cctgagacac tttgtggcgc tgaactggtg gacgccctgc agtttgtgtg tggcgacaga      600

ggcttctact tcaacaagcc cacaggctac ggcagcagct ctagaagggc tcctcagacc      660

ggaatcgtgg acgagtgctg cttcagaagc tgcgacctgc ggcggctgga aatgtattgt      720

gcccctctga agcctgccaa gagcgcctaa ctgggcctca tgggccttcc gctcactgcc      780

cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa catggtcata gctgtttcct      840

tgcgtattgg gcgctctccg cttcctcgct cactgactcg ctgcgctcgg tcgttcgggt      900

aaagcctggg gtgcctaatg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc      960

gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc     1020

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga     1080

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt     1140

ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg     1200

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc     1260

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg     1320

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc     1380

ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg     1440

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc     1500

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct     1560

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt     1620

taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa     1680

aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa     1740

tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc     1800

tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct     1860

gcaatgatac cgcgagaacc acgctcaccg gctccagatt tatcagcaat aaaccagcca     1920

gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt     1980

aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt     2040

gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     2100

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     2160

tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt     2220

atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact     2280

ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc     2340

ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt     2400

ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg     2460

atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct     2520

gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa     2580

tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     2640

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     2700

acatttcccc gaaaagtgcc ac                                              2722


<210>  61
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu 
            20                  25                  


<210>  62
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CSF3 SP

<400>  62
atggccggac ctgccacaca gtctccaatg aagctgatgg ccctgcagct gctgctgtgg       60

cattctgctc tgtggaccgt gcaagaa                                           87


<210>  63
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.12

<400>  63
atggccggac ctgccacaca gtctccaatg aagctgatgg ccctgcagct gctgctgtgg       60

cattctgctc tgtggaccgt gcaagaagtg aagatgcaca ccatgagcag cagccacctg      120

ttctatctgg ccctgtgcct gctgaccttt accagctctg ctaccgccgg accagagaca      180

ctttgtggcg ctgaactggt ggacgccctg cagtttgtgt gtggcgacag aggcttctac      240

ttcaacaagc ccacaggcta cggcagcagc tctagaaggg ctcctcagac cggaatcgtg      300

gacgagtgct gcttcagaag ctgcgacctg cggcggctgg aaatgtattg tgcccctctg      360

aagcctgcca agagcgccta a                                                381


<210>  64
<211>  381
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.12


<220>
<221>  modified_base
<222>  (1)..(381)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  64
auggccggac cugccacaca gucuccaaug aagcugaugg cccugcagcu gcugcugugg       60

cauucugcuc uguggaccgu gcaagaagug aagaugcaca ccaugagcag cagccaccug      120

uucuaucugg cccugugccu gcugaccuuu accagcucug cuaccgccgg accagagaca      180

cuuuguggcg cugaacuggu ggacgcccug caguuugugu guggcgacag aggcuucuac      240

uucaacaagc ccacaggcua cggcagcagc ucuagaaggg cuccucagac cggaaucgug      300

gacgagugcu gcuucagaag cugcgaccug cggcggcugg aaauguauug ugccccucug      360

aagccugcca agagcgccua a                                                381


<210>  65
<211>  2841
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.12

<400>  65
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg gatcctatca tccctttgaa tggaagcctc cgtaaaacga cggccagtta      420

atacgactca ctatagggcc accatggccg gacctgccac acagtctcca atgaagctga      480

tggccctgca gctgctgctg tggcattctg ctctgtggac cgtgcaagaa gtgaagatgc      540

acaccatgag cagcagccac ctgttctatc tggccctgtg cctgctgacc tttaccagct      600

ctgctaccgc cggaccagag acactttgtg gcgctgaact ggtggacgcc ctgcagtttg      660

tgtgtggcga cagaggcttc tacttcaaca agcccacagg ctacggcagc agctctagaa      720

gggctcctca gaccggaatc gtggacgagt gctgcttcag aagctgcgac ctgcggcggc      780

tggaaatgta ttgtgcccct ctgaagcctg ccaagagcgc ctaacaggaa acagctatga      840

cgcaaagcgt tgagagtggt aacgaattcc tgggcctcat gggccttccg ctcactgccc      900

gctttccagt cgggaaacct gtcgtgccag ctgcattaac atggtcatag ctgtttcctt      960

gcgtattggg cgctctccgc ttcctcgctc actgactcgc tgcgctcggt cgttcgggta     1020

aagcctgggg tgcctaatga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg     1080

cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct     1140

caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa     1200

gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc     1260

tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc agttcggtgt     1320

aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg     1380

ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg     1440

cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct     1500

tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc tgcgctctgc     1560

tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg     1620

ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc     1680

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt     1740

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa     1800

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat     1860

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct     1920

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg     1980

caatgatacc gcgagaacca cgctcaccgg ctccagattt atcagcaata aaccagccag     2040

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta     2100

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg     2160

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg     2220

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct     2280

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta     2340

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg     2400

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc     2460

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg     2520

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga     2580

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg     2640

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat     2700

gttgaatact catactcttc ctttttcaat attattgaag catttatcag ggttattgtc     2760

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca     2820

catttccccg aaaagtgcca c                                               2841


<210>  66
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ser Met Leu Phe Tyr Thr Leu Ile Thr Ala Phe Leu Ile Gly Ile 
1               5                   10                  15      


Gln Ala 
        


<210>  67
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NGF SP

<400>  67
atgagcatgc tgttctatac cctgatcacc gcctttctga tcggcatcca ggcc             54


<210>  68
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.13

<400>  68
atgagcatgc tgttctatac cctgatcacc gcctttctga tcggcatcca ggccgtgaag       60

atgcacacca tgtctagcag ccacctgttc tatctggccc tgtgcctgct gacctttacc      120

agctctgcta ccgccggacc tgagacactt tgtggcgctg aactggtgga cgccctgcag      180

tttgtgtgtg gcgacagagg cttctacttc aacaagccca caggctacgg cagcagctct      240

agaagggctc ctcagaccgg aatcgtggac gagtgctgct tcagaagctg cgacctgcgg      300

cggctggaaa tgtattgtgc ccctctgaag cctgccaaga gcgcctaa                   348


<210>  69
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.13


<220>
<221>  modified_base
<222>  (1)..(348)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  69
augagcaugc uguucuauac ccugaucacc gccuuucuga ucggcaucca ggccgugaag       60

augcacacca ugucuagcag ccaccuguuc uaucuggccc ugugccugcu gaccuuuacc      120

agcucugcua ccgccggacc ugagacacuu uguggcgcug aacuggugga cgcccugcag      180

uuugugugug gcgacagagg cuucuacuuc aacaagccca caggcuacgg cagcagcucu      240

agaagggcuc cucagaccgg aaucguggac gagugcugcu ucagaagcug cgaccugcgg      300

cggcuggaaa uguauugugc cccucugaag ccugccaaga gcgccuaa                   348


<210>  70
<211>  2808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.13

<400>  70
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg gatcctatca tccctttgaa tggaagcctc cgtaaaacga cggccagtta      420

atacgactca ctatagggcc accatgagca tgctgttcta taccctgatc accgcctttc      480

tgatcggcat ccaggccgtg aagatgcaca ccatgtctag cagccacctg ttctatctgg      540

ccctgtgcct gctgaccttt accagctctg ctaccgccgg acctgagaca ctttgtggcg      600

ctgaactggt ggacgccctg cagtttgtgt gtggcgacag aggcttctac ttcaacaagc      660

ccacaggcta cggcagcagc tctagaaggg ctcctcagac cggaatcgtg gacgagtgct      720

gcttcagaag ctgcgacctg cggcggctgg aaatgtattg tgcccctctg aagcctgcca      780

agagcgccta acaggaaaca gctatgacgc aaagcgttga gagtggtaac gaattcctgg      840

gcctcatggg ccttccgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg      900

cattaacatg gtcatagctg tttccttgcg tattgggcgc tctccgcttc ctcgctcact      960

gactcgctgc gctcggtcgt tcgggtaaag cctggggtgc ctaatgagca aaaggccagc     1020

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     1080

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     1140

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     1200

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     1260

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     1320

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     1380

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     1440

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     1500

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     1560

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc     1620

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg     1680

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga     1740

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg     1800

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct     1860

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg     1920

agggcttacc atctggcccc agtgctgcaa tgataccgcg agaaccacgc tcaccggctc     1980

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa     2040

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc     2100

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt     2160

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc     2220

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt     2280

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc     2340

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt     2400

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata     2460

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga     2520

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag     2580

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa     2640

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt     2700

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga     2760

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccac                  2808


<210>  71
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.30

<400>  71
atggctctgt ggatgagact gctgcctctg ctggcactgc ttgctctgtg gggacctgat       60

cctgccgccg cttttgtgaa tcagcacctg tgtggcagcc acctggtgga agccctgtat      120

ctcgtgtgtg gcgagcgggg cttcttctac acccctaaga caagaagaga ggccgaggac      180

ctgcaagtcg gccaggttga acttggcgga ggacctggtg ctggatctct gcaacctctg      240

gctctggaag gcagcctgca gaagaggggc atcgtcgagc agtgctgcac cagcatctgt      300

agcctgtacc agctggaaaa ctactgcaac tga                                   333


<210>  72
<211>  333
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.30


<220>
<221>  modified_base
<222>  (1)..(333)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  72
auggcucugu ggaugagacu gcugccucug cuggcacugc uugcucugug gggaccugau       60

ccugccgccg cuuuugugaa ucagcaccug uguggcagcc accuggugga agcccuguau      120

cucgugugug gcgagcgggg cuucuucuac accccuaaga caagaagaga ggccgaggac      180

cugcaagucg gccagguuga acuuggcgga ggaccuggug cuggaucucu gcaaccucug      240

gcucuggaag gcagccugca gaagaggggc aucgucgagc agugcugcac cagcaucugu      300

agccuguacc agcuggaaaa cuacugcaac uga                                   333


<210>  73
<211>  2680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.30

<400>  73
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatggc tctgtggatg agactgctgc ctctgctggc actgcttgct      420

ctgtggggac ctgatcctgc cgccgctttt gtgaatcagc acctgtgtgg cagccacctg      480

gtggaagccc tgtatctcgt gtgtggcgag cggggcttct tctacacccc taagacaaga      540

agagaggccg aggacctgca agtcggccag gttgaacttg gcggaggacc tggtgctgga      600

tctctgcaac ctctggctct ggaaggcagc ctgcagaaga ggggcatcgt cgagcagtgc      660

tgcaccagca tctgtagcct gtaccagctg gaaaactact gcaactgact gggcctcatg      720

ggccttccgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaaca      780

tggtcatagc tgtttccttg cgtattgggc gctctccgct tcctcgctca ctgactcgct      840

gcgctcggtc gttcgggtaa agcctggggt gcctaatgag caaaaggcca gcaaaaggcc      900

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag      960

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     1020

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     1080

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     1140

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     1200

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     1260

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     1320

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta     1380

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     1440

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     1500

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     1560

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     1620

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     1680

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     1740

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     1800

ccatctggcc ccagtgctgc aatgataccg cgagaaccac gctcaccggc tccagattta     1860

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     1920

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     1980

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     2040

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     2100

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     2160

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     2220

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     2280

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     2340

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     2400

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     2460

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2520

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2580

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     2640

caaatagggg ttccgcgcac atttccccga aaagtgccac                           2680


<210>  74
<211>  582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.27

<400>  74
atgggagtgc atgaatgtcc tgcttggctg tggctgctgc tgagcctgct gtctctgcct       60

ctgggactgc ctgttcttgg agcccctcct agactgatct gcgacagcag agtgctggaa      120

agatacctgc tggaagccaa agaggccgag aacatcacca caggctgtgc cgagcactgc      180

agcctgaacg agaatatcac cgtgcctgac accaaagtga acttctacgc ctggaagcgg      240

atggaagtgg gccagcaggc tgtggaagtt tggcaaggac tggccctgct gagcgaagct      300

gttctgagag gacaggctct gctggtcaac agctctcagc cttgggaacc tctgcaactg      360

cacgtggaca aggccgtgtc tggcctgaga agcctgacca cactgctgag agcactggga      420

gcccagaaag aggccatctc tccacctgat gctgcctctg ctgcccctct gagaaccatc      480

accgccgaca ccttcagaaa gctgttccgg gtgtacagca acttcctgcg gggcaagctg      540

aagctgtaca caggcgaggc ttgcagaacc ggcgacagat aa                         582


<210>  75
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.27


<220>
<221>  modified_base
<222>  (1)..(582)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  75
augggagugc augaaugucc ugcuuggcug uggcugcugc ugagccugcu gucucugccu       60

cugggacugc cuguucuugg agccccuccu agacugaucu gcgacagcag agugcuggaa      120

agauaccugc uggaagccaa agaggccgag aacaucacca caggcugugc cgagcacugc      180

agccugaacg agaauaucac cgugccugac accaaaguga acuucuacgc cuggaagcgg      240

auggaagugg gccagcaggc uguggaaguu uggcaaggac uggcccugcu gagcgaagcu      300

guucugagag gacaggcucu gcuggucaac agcucucagc cuugggaacc ucugcaacug      360

cacguggaca aggccguguc uggccugaga agccugacca cacugcugag agcacuggga      420

gcccagaaag aggccaucuc uccaccugau gcugccucug cugccccucu gagaaccauc      480

accgccgaca ccuucagaaa gcuguuccgg guguacagca acuuccugcg gggcaagcug      540

aagcuguaca caggcgaggc uugcagaacc ggcgacagau aa                         582


<210>  76
<211>  2929
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.27

<400>  76
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatggg agtgcatgaa tgtcctgctt ggctgtggct gctgctgagc      420

ctgctgtctc tgcctctggg actgcctgtt cttggagccc ctcctagact gatctgcgac      480

agcagagtgc tggaaagata cctgctggaa gccaaagagg ccgagaacat caccacaggc      540

tgtgccgagc actgcagcct gaacgagaat atcaccgtgc ctgacaccaa agtgaacttc      600

tacgcctgga agcggatgga agtgggccag caggctgtgg aagtttggca aggactggcc      660

ctgctgagcg aagctgttct gagaggacag gctctgctgg tcaacagctc tcagccttgg      720

gaacctctgc aactgcacgt ggacaaggcc gtgtctggcc tgagaagcct gaccacactg      780

ctgagagcac tgggagccca gaaagaggcc atctctccac ctgatgctgc ctctgctgcc      840

cctctgagaa ccatcaccgc cgacaccttc agaaagctgt tccgggtgta cagcaacttc      900

ctgcggggca agctgaagct gtacacaggc gaggcttgca gaaccggcga cagataactg      960

ggcctcatgg gccttccgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct     1020

gcattaacat ggtcatagct gtttccttgc gtattgggcg ctctccgctt cctcgctcac     1080

tgactcgctg cgctcggtcg ttcgggtaaa gcctggggtg cctaatgagc aaaaggccag     1140

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     1200

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     1260

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     1320

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     1380

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     1440

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     1500

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     1560

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     1620

agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     1680

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     1740

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     1800

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     1860

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     1920

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     1980

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     2040

gagggcttac catctggccc cagtgctgca atgataccgc gagaaccacg ctcaccggct     2100

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     2160

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg     2220

ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg     2280

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc     2340

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag     2400

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg     2460

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag     2520

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat     2580

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg     2640

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca     2700

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca     2760

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat     2820

tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag     2880

aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccac                 2929


<210>  77
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly 
            20                  


<210>  78
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL4 SP

<400>  78
atgggactga catctcaact gctgcctcca ctgttctttc tgctggcctg cgccggcaat       60

tttgtgcacg gc                                                           72


<210>  79
<211>  462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.33

<400>  79
atgggactga catctcaact gctgcctcca ctgttctttc tgctggcctg cgccggcaat       60

tttgtgcacg gccacaagtg cgacatcacc ctgcaagaga tcatcaagac cctgaacagc      120

ctgaccgagc agaaaaccct gtgcaccgag ctgaccgtga ccgatatctt tgccgccagc      180

aagaacacaa ccgagaaaga gacattctgc agagccgcca ccgtgctgag acagttctac      240

agccaccacg agaaggacac cagatgcctg ggagctacag cccagcagtt ccacagacac      300

aagcagctga tccggttcct gaagcggctg gacagaaatc tgtggggact cgccggcctg      360

aatagctgcc ctgtgaaaga ggccaaccag tctaccctgg aaaacttcct ggaacggctg      420

aaaaccatca tgcgcgagaa gtacagcaag tgcagcagct ga                         462


<210>  80
<211>  462
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.33


<220>
<221>  modified_base
<222>  (1)..(462)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  80
augggacuga caucucaacu gcugccucca cuguucuuuc ugcuggccug cgccggcaau       60

uuugugcacg gccacaagug cgacaucacc cugcaagaga ucaucaagac ccugaacagc      120

cugaccgagc agaaaacccu gugcaccgag cugaccguga ccgauaucuu ugccgccagc      180

aagaacacaa ccgagaaaga gacauucugc agagccgcca ccgugcugag acaguucuac      240

agccaccacg agaaggacac cagaugccug ggagcuacag cccagcaguu ccacagacac      300

aagcagcuga uccgguuccu gaagcggcug gacagaaauc uguggggacu cgccggccug      360

aauagcugcc cugugaaaga ggccaaccag ucuacccugg aaaacuuccu ggaacggcug      420

aaaaccauca ugcgcgagaa guacagcaag ugcagcagcu ga                         462


<210>  81
<211>  2809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.33

<400>  81
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatggg actgacatct caactgctgc ctccactgtt ctttctgctg      420

gcctgcgccg gcaattttgt gcacggccac aagtgcgaca tcaccctgca agagatcatc      480

aagaccctga acagcctgac cgagcagaaa accctgtgca ccgagctgac cgtgaccgat      540

atctttgccg ccagcaagaa cacaaccgag aaagagacat tctgcagagc cgccaccgtg      600

ctgagacagt tctacagcca ccacgagaag gacaccagat gcctgggagc tacagcccag      660

cagttccaca gacacaagca gctgatccgg ttcctgaagc ggctggacag aaatctgtgg      720

ggactcgccg gcctgaatag ctgccctgtg aaagaggcca accagtctac cctggaaaac      780

ttcctggaac ggctgaaaac catcatgcgc gagaagtaca gcaagtgcag cagctgactg      840

ggcctcatgg gccttccgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct      900

gcattaacat ggtcatagct gtttccttgc gtattgggcg ctctccgctt cctcgctcac      960

tgactcgctg cgctcggtcg ttcgggtaaa gcctggggtg cctaatgagc aaaaggccag     1020

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     1080

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     1140

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     1200

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     1260

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     1320

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     1380

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     1440

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     1500

agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     1560

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     1620

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     1680

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     1740

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     1800

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     1860

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     1920

gagggcttac catctggccc cagtgctgca atgataccgc gagaaccacg ctcaccggct     1980

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     2040

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg     2100

ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg     2160

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc     2220

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag     2280

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg     2340

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag     2400

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat     2460

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg     2520

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca     2580

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca     2640

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat     2700

tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag     2760

aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccac                 2809


<210>  82
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  82

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala 
        


<210>  83
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL10 SP

<400>  83
atgcatagct ctgccctgct gtgttgtctg gtgctgctga caggcgtcag agcc             54


<210>  84
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.36

<400>  84
atgcatagct ctgccctgct gtgttgtctg gtgctgctga caggcgtcag agcctctcct       60

ggacagggaa cccagagcga gaatagctgc acccactttc caggcaacct gcctaacatg      120

ctgcgggacc tgagagatgc cttcagcaga gtgaaaacat tcttccagat gaaggaccag      180

ctggacaacc tgctgctgaa agagagcctg ctggaagatt tcaagggcta cctgggctgt      240

caggccctga gcgagatgat ccagttctac ctggaagaag tgatgcccca ggccgagaat      300

caggaccccg atattaaggc ccacgtgaac agcctgggcg agaacctgaa aaccctgcgg      360

ctgagactgc ggcggtgcca cagatttctg ccttgcgaga acaagagcaa ggccgtggaa      420

caagtgaaga acgccttcaa caagctgcaa gagaagggca tctacaaggc catgtccgag      480

ttcgacatct tcatcaacta catcgaggcc tacatgacca tgaagatccg gaactga         537


<210>  85
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.36


<220>
<221>  modified_base
<222>  (1)..(537)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  85
augcauagcu cugcccugcu guguugucug gugcugcuga caggcgucag agccucuccu       60

ggacagggaa cccagagcga gaauagcugc acccacuuuc caggcaaccu gccuaacaug      120

cugcgggacc ugagagaugc cuucagcaga gugaaaacau ucuuccagau gaaggaccag      180

cuggacaacc ugcugcugaa agagagccug cuggaagauu ucaagggcua ccugggcugu      240

caggcccuga gcgagaugau ccaguucuac cuggaagaag ugaugcccca ggccgagaau      300

caggaccccg auauuaaggc ccacgugaac agccugggcg agaaccugaa aacccugcgg      360

cugagacugc ggcggugcca cagauuucug ccuugcgaga acaagagcaa ggccguggaa      420

caagugaaga acgccuucaa caagcugcaa gagaagggca ucuacaaggc cauguccgag      480

uucgacaucu ucaucaacua caucgaggcc uacaugacca ugaagauccg gaacuga         537


<210>  86
<211>  2884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.36

<400>  86
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatgca tagctctgcc ctgctgtgtt gtctggtgct gctgacaggc      420

gtcagagcct ctcctggaca gggaacccag agcgagaata gctgcaccca ctttccaggc      480

aacctgccta acatgctgcg ggacctgaga gatgccttca gcagagtgaa aacattcttc      540

cagatgaagg accagctgga caacctgctg ctgaaagaga gcctgctgga agatttcaag      600

ggctacctgg gctgtcaggc cctgagcgag atgatccagt tctacctgga agaagtgatg      660

ccccaggccg agaatcagga ccccgatatt aaggcccacg tgaacagcct gggcgagaac      720

ctgaaaaccc tgcggctgag actgcggcgg tgccacagat ttctgccttg cgagaacaag      780

agcaaggccg tggaacaagt gaagaacgcc ttcaacaagc tgcaagagaa gggcatctac      840

aaggccatgt ccgagttcga catcttcatc aactacatcg aggcctacat gaccatgaag      900

atccggaact gactgggcct catgggcctt ccgctcactg cccgctttcc agtcgggaaa      960

cctgtcgtgc cagctgcatt aacatggtca tagctgtttc cttgcgtatt gggcgctctc     1020

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg gtaaagcctg gggtgcctaa     1080

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     1140

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     1200

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     1260

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     1320

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     1380

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     1440

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     1500

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     1560

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc     1620

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     1680

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     1740

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     1800

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     1860

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     1920

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     1980

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagaa     2040

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     2100

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     2160

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     2220

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     2280

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     2340

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     2400

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     2460

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     2520

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     2580

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     2640

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     2700

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     2760

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     2820

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     2880

ccac                                                                  2884


<210>  87
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ser Leu Ser Phe Leu Leu Leu Leu Phe Phe Ser His Leu Ile Leu 
1               5                   10                  15      


Ser Ala Trp Ala 
            20  


<210>  88
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FGF5 SP

<400>  88
atgagcctga gctttctgct gctgctgttc ttcagccacc tgatcctgtc tgcctgggcc       60


<210>  89
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.14

<400>  89
atgagcctga gctttctgct gctgctgttc ttcagccacc tgatcctgtc tgcctgggcc       60

gtgaagatgc acaccatgtc cagctctcac ctgttctatc tggccctgtg cctgctgacc      120

tttaccagct ctgctaccgc cggacctgag acactttgtg gcgctgaact ggtggacgcc      180

ctgcagtttg tgtgtggcga cagaggcttc tacttcaaca agcccacagg ctacggcagc      240

agctctagaa gggctcctca gaccggaatc gtggacgagt gctgcttcag aagctgcgac      300

ctgcggcggc tggaaatgta ttgtgcccct ctgaagcctg ccaagagcgc ctaa            354


<210>  90
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.14


<220>
<221>  modified_base
<222>  (1)..(354)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  90
augagccuga gcuuucugcu gcugcuguuc uucagccacc ugauccuguc ugccugggcc       60

gugaagaugc acaccauguc cagcucucac cuguucuauc uggcccugug ccugcugacc      120

uuuaccagcu cugcuaccgc cggaccugag acacuuugug gcgcugaacu gguggacgcc      180

cugcaguuug uguguggcga cagaggcuuc uacuucaaca agcccacagg cuacggcagc      240

agcucuagaa gggcuccuca gaccggaauc guggacgagu gcugcuucag aagcugcgac      300

cugcggcggc uggaaaugua uugugccccu cugaagccug ccaagagcgc cuaa            354


<210>  91
<211>  2701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.14

<400>  91
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatgag cctgagcttt ctgctgctgc tgttcttcag ccacctgatc      420

ctgtctgcct gggccgtgaa gatgcacacc atgtccagct ctcacctgtt ctatctggcc      480

ctgtgcctgc tgacctttac cagctctgct accgccggac ctgagacact ttgtggcgct      540

gaactggtgg acgccctgca gtttgtgtgt ggcgacagag gcttctactt caacaagccc      600

acaggctacg gcagcagctc tagaagggct cctcagaccg gaatcgtgga cgagtgctgc      660

ttcagaagct gcgacctgcg gcggctggaa atgtattgtg cccctctgaa gcctgccaag      720

agcgcctaac tgggcctcat gggccttccg ctcactgccc gctttccagt cgggaaacct      780

gtcgtgccag ctgcattaac atggtcatag ctgtttcctt gcgtattggg cgctctccgc      840

ttcctcgctc actgactcgc tgcgctcggt cgttcgggta aagcctgggg tgcctaatga      900

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat      960

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     1020

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     1080

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     1140

ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     1200

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     1260

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     1320

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     1380

ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     1440

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     1500

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     1560

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     1620

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     1680

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     1740

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     1800

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaacca     1860

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     1920

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     1980

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     2040

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     2100

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     2160

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     2220

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     2280

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     2340

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     2400

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     2460

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     2520

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     2580

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     2640

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     2700

c                                                                     2701


<210>  92
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly 
        


<210>  93
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FHR2 SP

<400>  93
atgtggctgc tggtgtctgt gatcctgatc agccggatct cttctgtcgg cggc             54


<210>  94
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.15

<400>  94
atgtggctgc tggtgtctgt gatcctgatc agccggatct cttctgtcgg cggcgtgaag       60

atgcacacca tgagcagctc ccacctgttc tatctggccc tgtgcctgct gacctttacc      120

agctctgcta ccgccggacc tgagacactt tgtggcgctg aactggtgga cgccctgcag      180

tttgtgtgtg gcgacagagg cttctacttc aacaagccca caggctacgg cagcagctct      240

agaagggctc ctcagaccgg aatcgtggac gagtgctgct tcagaagctg cgacctgcgg      300

cggctggaaa tgtattgtgc ccctctgaag cctgccaaga gcgcctaa                   348


<210>  95
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.15


<220>
<221>  modified_base
<222>  (1)..(348)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  95
auguggcugc uggugucugu gauccugauc agccggaucu cuucugucgg cggcgugaag       60

augcacacca ugagcagcuc ccaccuguuc uaucuggccc ugugccugcu gaccuuuacc      120

agcucugcua ccgccggacc ugagacacuu uguggcgcug aacuggugga cgcccugcag      180

uuugugugug gcgacagagg cuucuacuuc aacaagccca caggcuacgg cagcagcucu      240

agaagggcuc cucagaccgg aaucguggac gagugcugcu ucagaagcug cgaccugcgg      300

cggcuggaaa uguauugugc cccucugaag ccugccaaga gcgccuaa                   348


<210>  96
<211>  2728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-T with Cpd.15

<400>  96
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catgtggctg ctggtgtctg tgatcctgat      420

cagccggatc tcttctgtcg gcggcgtgaa gatgcacacc atgagcagct cccacctgtt      480

ctatctggcc ctgtgcctgc tgacctttac cagctctgct accgccggac ctgagacact      540

ttgtggcgct gaactggtgg acgccctgca gtttgtgtgt ggcgacagag gcttctactt      600

caacaagccc acaggctacg gcagcagctc tagaagggct cctcagaccg gaatcgtgga      660

cgagtgctgc ttcagaagct gcgacctgcg gcggctggaa atgtattgtg cccctctgaa      720

gcctgccaag agcgcctaag gtacctggag cacaagactg gcctcatggg ccttccgctc      780

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaacatg gtcatagctg      840

tttccttgcg tattgggcgc tctccgcttc ctcgctcact gactcgctgc gctcggtcgt      900

tcgggtaaag cctggggtgc ctaatgagca aaaggccagc aaaaggccag gaaccgtaaa      960

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     1020

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     1080

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     1140

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     1200

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     1260

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     1320

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     1380

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc     1440

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa     1500

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa     1560

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac     1620

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta     1680

aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt     1740

taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata     1800

gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc     1860

agtgctgcaa tgataccgcg agaaccacgc tcaccggctc cagatttatc agcaataaac     1920

cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag     1980

tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac     2040

gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc     2100

agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg     2160

gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc     2220

atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct     2280

gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc     2340

tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc     2400

atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc     2460

agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc     2520

gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca     2580

cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt     2640

tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt     2700

ccgcgcacat ttccccgaaa agtgccac                                        2728


<210>  97
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Val Leu Leu Thr Ala Val Leu Leu Leu Leu Ala Ala Tyr Ala Gly 
1               5                   10                  15      


Pro Ala Gln Ser 
            20  


<210>  98
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IBP5 SP

<400>  98
atggttctgc tgacagctgt tctgctgctg ctggccgctt atgctggacc tgctcagagc       60


<210>  99
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.16

<400>  99
atggttctgc tgacagctgt tctgctgctg ctggccgctt atgctggacc tgctcagagc       60

gtgaagatgc acaccatgag cagcagccac ctgttctatc tggccctgtg cctgctgacc      120

tttaccagct ctgctaccgc cggacctgag acactttgtg gcgctgaact ggtggacgcc      180

ctgcagtttg tgtgtggcga cagaggcttc tacttcaaca agcccacagg ctacggcagc      240

agctctagaa gggctcctca gaccggaatc gtggacgagt gctgcttcag aagctgcgac      300

ctgcggcggc tggaaatgta ttgtgcccct ctgaagcctg ccaagagcgc ctaa            354


<210>  100
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.16


<220>
<221>  modified_base
<222>  (1)..(354)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  100
augguucugc ugacagcugu ucugcugcug cuggccgcuu augcuggacc ugcucagagc       60

gugaagaugc acaccaugag cagcagccac cuguucuauc uggcccugug ccugcugacc      120

uuuaccagcu cugcuaccgc cggaccugag acacuuugug gcgcugaacu gguggacgcc      180

cugcaguuug uguguggcga cagaggcuuc uacuucaaca agcccacagg cuacggcagc      240

agcucuagaa gggcuccuca gaccggaauc guggacgagu gcugcuucag aagcugcgac      300

cugcggcggc uggaaaugua uugugccccu cugaagccug ccaagagcgc cuaa            354


<210>  101
<211>  2701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.16

<400>  101
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatggt tctgctgaca gctgttctgc tgctgctggc cgcttatgct      420

ggacctgctc agagcgtgaa gatgcacacc atgagcagca gccacctgtt ctatctggcc      480

ctgtgcctgc tgacctttac cagctctgct accgccggac ctgagacact ttgtggcgct      540

gaactggtgg acgccctgca gtttgtgtgt ggcgacagag gcttctactt caacaagccc      600

acaggctacg gcagcagctc tagaagggct cctcagaccg gaatcgtgga cgagtgctgc      660

ttcagaagct gcgacctgcg gcggctggaa atgtattgtg cccctctgaa gcctgccaag      720

agcgcctaac tgggcctcat gggccttccg ctcactgccc gctttccagt cgggaaacct      780

gtcgtgccag ctgcattaac atggtcatag ctgtttcctt gcgtattggg cgctctccgc      840

ttcctcgctc actgactcgc tgcgctcggt cgttcgggta aagcctgggg tgcctaatga      900

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat      960

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     1020

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     1080

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     1140

ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     1200

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     1260

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     1320

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     1380

ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     1440

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     1500

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     1560

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     1620

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     1680

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     1740

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     1800

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaacca     1860

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     1920

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     1980

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     2040

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     2100

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     2160

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     2220

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     2280

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     2340

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     2400

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     2460

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     2520

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     2580

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     2640

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     2700

c                                                                     2701


<210>  102
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ser Ile Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile 
1               5                   10                  15      


Gln Gly 
        


<210>  103
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NTF3 SP

<400>  103
atgagcatcc tgttctacgt gatcttcctg gcctacctga gaggcatcca gggc             54


<210>  104
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.17

<400>  104
atgagcatcc tgttctacgt gatcttcctg gcctacctga gaggcatcca gggcgtgaag       60

atgcacacca tgtctagcag ccacctgttc tatctggccc tgtgcctgct gacctttacc      120

agctctgcta ccgccggacc tgagacactt tgtggcgctg aactggtgga cgccctgcag      180

tttgtgtgtg gcgacagagg cttctacttc aacaagccca caggctacgg cagcagctct      240

agaagggctc ctcagaccgg aatcgtggac gagtgctgct tcagaagctg cgacctgcgg      300

cggctggaaa tgtattgtgc ccctctgaag cctgccaaga gcgcctaa                   348


<210>  105
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.17


<220>
<221>  modified_base
<222>  (1)..(348)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  105
augagcaucc uguucuacgu gaucuuccug gccuaccuga gaggcaucca gggcgugaag       60

augcacacca ugucuagcag ccaccuguuc uaucuggccc ugugccugcu gaccuuuacc      120

agcucugcua ccgccggacc ugagacacuu uguggcgcug aacuggugga cgcccugcag      180

uuugugugug gcgacagagg cuucuacuuc aacaagccca caggcuacgg cagcagcucu      240

agaagggcuc cucagaccgg aaucguggac gagugcugcu ucagaagcug cgaccugcgg      300

cggcuggaaa uguauugugc cccucugaag ccugccaaga gcgccuaa                   348


<210>  106
<211>  2808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.17

<400>  106
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg gatcctatca tccctttgaa tggaagcctc cgtaaaacga cggccagtta      420

atacgactca ctatagggcc accatgagca tcctgttcta cgtgatcttc ctggcctacc      480

tgagaggcat ccagggcgtg aagatgcaca ccatgtctag cagccacctg ttctatctgg      540

ccctgtgcct gctgaccttt accagctctg ctaccgccgg acctgagaca ctttgtggcg      600

ctgaactggt ggacgccctg cagtttgtgt gtggcgacag aggcttctac ttcaacaagc      660

ccacaggcta cggcagcagc tctagaaggg ctcctcagac cggaatcgtg gacgagtgct      720

gcttcagaag ctgcgacctg cggcggctgg aaatgtattg tgcccctctg aagcctgcca      780

agagcgccta acaggaaaca gctatgacgc aaagcgttga gagtggtaac gaattcctgg      840

gcctcatggg ccttccgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg      900

cattaacatg gtcatagctg tttccttgcg tattgggcgc tctccgcttc ctcgctcact      960

gactcgctgc gctcggtcgt tcgggtaaag cctggggtgc ctaatgagca aaaggccagc     1020

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     1080

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     1140

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     1200

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     1260

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     1320

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     1380

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     1440

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     1500

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     1560

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc     1620

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg     1680

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga     1740

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg     1800

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct     1860

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg     1920

agggcttacc atctggcccc agtgctgcaa tgataccgcg agaaccacgc tcaccggctc     1980

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa     2040

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc     2100

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt     2160

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc     2220

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt     2280

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc     2340

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt     2400

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata     2460

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga     2520

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag     2580

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa     2640

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt     2700

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga     2760

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccac                  2808


<210>  107
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Leu Val Leu Phe Leu Leu Gly Thr Val Phe Leu Leu Cys Pro Tyr 
1               5                   10                  15      


Trp Gly Glu Leu His Asp Pro Ile Lys Ala 
            20                  25      


<210>  108
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PATE2 SP

<400>  108
atgctggtgc tgtttctgct gggcaccgtc tttctgctgt gcccttattg gggcgagctg       60

cacgatccta tcaaggcc                                                     78


<210>  109
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.18

<400>  109
atgctggtgc tgtttctgct gggcaccgtc tttctgctgt gcccttattg gggcgagctg       60

cacgatccta tcaaggccgt gaagatgcac accatgagca gcagccacct gttctatctg      120

gccctgtgcc tgctgacctt taccagctct gctaccgccg gacctgagac actttgtggc      180

gctgaactgg tggacgccct gcagtttgtg tgtggcgaca gaggcttcta cttcaacaag      240

cccacaggct acggcagcag ctctagaagg gctcctcaga ccggaatcgt ggacgagtgc      300

tgcttcagaa gctgcgacct gcggcggctg gaaatgtatt gtgcccctct gaagcctgcc      360

aagagcgcct aa                                                          372


<210>  110
<211>  372
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.18


<220>
<221>  modified_base
<222>  (1)..(372)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  110
augcuggugc uguuucugcu gggcaccguc uuucugcugu gcccuuauug gggcgagcug       60

cacgauccua ucaaggccgu gaagaugcac accaugagca gcagccaccu guucuaucug      120

gcccugugcc ugcugaccuu uaccagcucu gcuaccgccg gaccugagac acuuuguggc      180

gcugaacugg uggacgcccu gcaguuugug uguggcgaca gaggcuucua cuucaacaag      240

cccacaggcu acggcagcag cucuagaagg gcuccucaga ccggaaucgu ggacgagugc      300

ugcuucagaa gcugcgaccu gcggcggcug gaaauguauu gugccccucu gaagccugcc      360

aagagcgccu aa                                                          372


<210>  111
<211>  2752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-T with Cpd.18

<400>  111
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catgctggtg ctgtttctgc tgggcaccgt      420

ctttctgctg tgcccttatt ggggcgagct gcacgatcct atcaaggccg tgaagatgca      480

caccatgagc agcagccacc tgttctatct ggccctgtgc ctgctgacct ttaccagctc      540

tgctaccgcc ggacctgaga cactttgtgg cgctgaactg gtggacgccc tgcagtttgt      600

gtgtggcgac agaggcttct acttcaacaa gcccacaggc tacggcagca gctctagaag      660

ggctcctcag accggaatcg tggacgagtg ctgcttcaga agctgcgacc tgcggcggct      720

ggaaatgtat tgtgcccctc tgaagcctgc caagagcgcc taaggtacct ggagcacaag      780

actggcctca tgggccttcc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca      840

gctgcattaa catggtcata gctgtttcct tgcgtattgg gcgctctccg cttcctcgct      900

cactgactcg ctgcgctcgg tcgttcgggt aaagcctggg gtgcctaatg agcaaaaggc      960

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     1020

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     1080

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     1140

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     1200

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     1260

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     1320

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     1380

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     1440

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     1500

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     1560

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     1620

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     1680

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     1740

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg     1800

atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata     1860

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaacc acgctcaccg     1920

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct     1980

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt     2040

tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc     2100

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga     2160

tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt     2220

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc     2280

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa     2340

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca     2400

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca     2460

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct     2520

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc     2580

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa     2640

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt     2700

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc ac             2752


<210>  112
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser 
1               5                   10                  15      


Asp Ala 
        


<210>  113
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD3 SP

<400>  113
atgcttgccc tgctgtgttc ttgtctgctg ctggctgctg gcgcctctga tgcc             54


<210>  114
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.19

<400>  114
atgcttgccc tgctgtgttc ttgtctgctg ctggctgctg gcgcctctga tgccgtgaag       60

atgcacacaa tgagcagcag ccacctgttc tatctggccc tgtgcctgct gacctttacc      120

agctctgcta ccgccggacc tgagacactt tgtggcgctg aactggtgga cgccctgcag      180

tttgtgtgtg gcgacagagg cttctacttc aacaagccca caggctacgg cagcagctct      240

agaagggctc ctcagaccgg aatcgtggac gagtgctgct tcagaagctg cgacctgcgg      300

cggctggaaa tgtattgtgc ccctctgaag cctgccaaga gcgcctaa                   348


<210>  115
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.19


<220>
<221>  modified_base
<222>  (1)..(348)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  115
augcuugccc ugcuguguuc uugucugcug cuggcugcug gcgccucuga ugccgugaag       60

augcacacaa ugagcagcag ccaccuguuc uaucuggccc ugugccugcu gaccuuuacc      120

agcucugcua ccgccggacc ugagacacuu uguggcgcug aacuggugga cgcccugcag      180

uuugugugug gcgacagagg cuucuacuuc aacaagccca caggcuacgg cagcagcucu      240

agaagggcuc cucagaccgg aaucguggac gagugcugcu ucagaagcug cgaccugcgg      300

cggcuggaaa uguauugugc cccucugaag ccugccaaga gcgccuaa                   348


<210>  116
<211>  2695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.19

<400>  116
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatgct tgccctgctg tgttcttgtc tgctgctggc tgctggcgcc      420

tctgatgccg tgaagatgca cacaatgagc agcagccacc tgttctatct ggccctgtgc      480

ctgctgacct ttaccagctc tgctaccgcc ggacctgaga cactttgtgg cgctgaactg      540

gtggacgccc tgcagtttgt gtgtggcgac agaggcttct acttcaacaa gcccacaggc      600

tacggcagca gctctagaag ggctcctcag accggaatcg tggacgagtg ctgcttcaga      660

agctgcgacc tgcggcggct ggaaatgtat tgtgcccctc tgaagcctgc caagagcgcc      720

taactgggcc tcatgggcct tccgctcact gcccgctttc cagtcgggaa acctgtcgtg      780

ccagctgcat taacatggtc atagctgttt ccttgcgtat tgggcgctct ccgcttcctc      840

gctcactgac tcgctgcgct cggtcgttcg ggtaaagcct ggggtgccta atgagcaaaa      900

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc      960

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     1020

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     1080

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     1140

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     1200

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     1260

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     1320

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac     1380

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga     1440

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc     1500

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     1560

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca     1620

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt     1680

atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca     1740

gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg     1800

atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga accacgctca     1860

ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt     1920

cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt     1980

agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca     2040

cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca     2100

tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga     2160

agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact     2220

gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga     2280

gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg     2340

ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc     2400

tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga     2460

tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat     2520

gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt     2580

caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt     2640

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccac          2695


<210>  117
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Leu Gly Ala Leu Leu Leu Ala Leu Ala Ile Leu Gly Gly Leu Ser 
1               5                   10                  15      


Lys Leu His Cys Thr Arg 
            20          


<210>  118
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GLR

<400>  118
atgcttggag cactgctgct ggccctggcc attcttggag gactgagcaa gctgcactgc       60

accaga                                                                  66


<210>  119
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.20

<400>  119
atgcttggag cactgctgct ggccctggcc attcttggag gactgagcaa gctgcactgc       60

accagagtga agatgcacac catgagcagc agccacctgt tctatctggc cctgtgcctg      120

ctgaccttta ccagctctgc taccgccgga cctgagacac tttgtggcgc tgaactggtg      180

gacgccctgc agtttgtgtg tggcgacaga ggcttctact tcaacaagcc cacaggctac      240

ggcagcagct ctagaagggc tcctcagacc ggaatcgtgg acgagtgctg cttcagaagc      300

tgcgacctgc ggcggctgga aatgtattgt gcccctctga agcctgccaa gagcgcctaa      360


<210>  120
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.20


<220>
<221>  modified_base
<222>  (1)..(360)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  120
augcuuggag cacugcugcu ggcccuggcc auucuuggag gacugagcaa gcugcacugc       60

accagaguga agaugcacac caugagcagc agccaccugu ucuaucuggc ccugugccug      120

cugaccuuua ccagcucugc uaccgccgga ccugagacac uuuguggcgc ugaacuggug      180

gacgcccugc aguuugugug uggcgacaga ggcuucuacu ucaacaagcc cacaggcuac      240

ggcagcagcu cuagaagggc uccucagacc ggaaucgugg acgagugcug cuucagaagc      300

ugcgaccugc ggcggcugga aauguauugu gccccucuga agccugccaa gagcgccuaa      360


<210>  121
<211>  2740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-T with Cpd.20

<400>  121
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catgcttgga gcactgctgc tggccctggc      420

cattcttgga ggactgagca agctgcactg caccagagtg aagatgcaca ccatgagcag      480

cagccacctg ttctatctgg ccctgtgcct gctgaccttt accagctctg ctaccgccgg      540

acctgagaca ctttgtggcg ctgaactggt ggacgccctg cagtttgtgt gtggcgacag      600

aggcttctac ttcaacaagc ccacaggcta cggcagcagc tctagaaggg ctcctcagac      660

cggaatcgtg gacgagtgct gcttcagaag ctgcgacctg cggcggctgg aaatgtattg      720

tgcccctctg aagcctgcca agagcgccta aggtacctgg agcacaagac tggcctcatg      780

ggccttccgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaaca      840

tggtcatagc tgtttccttg cgtattgggc gctctccgct tcctcgctca ctgactcgct      900

gcgctcggtc gttcgggtaa agcctggggt gcctaatgag caaaaggcca gcaaaaggcc      960

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     1020

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     1080

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     1140

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     1200

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     1260

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     1320

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     1380

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta     1440

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     1500

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     1560

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     1620

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     1680

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     1740

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     1800

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     1860

ccatctggcc ccagtgctgc aatgataccg cgagaaccac gctcaccggc tccagattta     1920

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     1980

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     2040

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     2100

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     2160

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     2220

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     2280

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     2340

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     2400

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     2460

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     2520

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2580

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2640

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     2700

caaatagggg ttccgcgcac atttccccga aaagtgccac                           2740


<210>  122
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1-Modified SP

<400>  122

Met Leu Ile Leu Leu Leu Pro Leu Leu Leu Phe Lys Cys Phe Cys Asp 
1               5                   10                  15      


Phe Leu Lys 
            


<210>  123
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGF1-Modified SP

<400>  123
atgctgattc tgctgctgcc cctgctgctg ttcaagtgct tctgcgactt cctgaaa          57


<210>  124
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.21

<400>  124
atgctgattc tgctgctgcc cctgctgctg ttcaagtgct tctgcgactt cctgaaagtg       60

aagatgcaca ccatgagcag cagccacctg ttctatctgg ccctgtgcct gctgaccttt      120

accagctctg ctaccgccgg acctgagaca ctttgtggcg ctgaactggt ggacgccctg      180

cagtttgtgt gtggcgacag aggcttctac ttcaacaagc ccacaggcta cggcagcagc      240

tctagaaggg ctcctcagac cggaatcgtg gacgagtgct gcttcagaag ctgcgacctg      300

cggcggctgg aaatgtattg tgcccctctg aagcctgcca agagcgccta a               351


<210>  125
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.21


<220>
<221>  modified_base
<222>  (1)..(351)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  125
augcugauuc ugcugcugcc ccugcugcug uucaagugcu ucugcgacuu ccugaaagug       60

aagaugcaca ccaugagcag cagccaccug uucuaucugg cccugugccu gcugaccuuu      120

accagcucug cuaccgccgg accugagaca cuuuguggcg cugaacuggu ggacgcccug      180

caguuugugu guggcgacag aggcuucuac uucaacaagc ccacaggcua cggcagcagc      240

ucuagaaggg cuccucagac cggaaucgug gacgagugcu gcuucagaag cugcgaccug      300

cggcggcugg aaauguauug ugccccucug aagccugcca agagcgccua a               351


<210>  126
<211>  2731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-T with Cpd.21

<400>  126
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catgctgatt ctgctgctgc ccctgctgct      420

gttcaagtgc ttctgcgact tcctgaaagt gaagatgcac accatgagca gcagccacct      480

gttctatctg gccctgtgcc tgctgacctt taccagctct gctaccgccg gacctgagac      540

actttgtggc gctgaactgg tggacgccct gcagtttgtg tgtggcgaca gaggcttcta      600

cttcaacaag cccacaggct acggcagcag ctctagaagg gctcctcaga ccggaatcgt      660

ggacgagtgc tgcttcagaa gctgcgacct gcggcggctg gaaatgtatt gtgcccctct      720

gaagcctgcc aagagcgcct aaggtacctg gagcacaaga ctggcctcat gggccttccg      780

ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaac atggtcatag      840

ctgtttcctt gcgtattggg cgctctccgc ttcctcgctc actgactcgc tgcgctcggt      900

cgttcgggta aagcctgggg tgcctaatga gcaaaaggcc agcaaaaggc caggaaccgt      960

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     1020

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     1080

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     1140

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     1200

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     1260

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     1320

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     1380

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     1440

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     1500

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     1560

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     1620

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     1680

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     1740

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     1800

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     1860

cccagtgctg caatgatacc gcgagaacca cgctcaccgg ctccagattt atcagcaata     1920

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     1980

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     2040

aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca     2100

ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa     2160

gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca     2220

ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt     2280

tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt     2340

tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg     2400

ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga     2460

tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc     2520

agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg     2580

acacggaaat gttgaatact catactcttc ctttttcaat attattgaag catttatcag     2640

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg     2700

gttccgcgca catttccccg aaaagtgcca c                                    2731


<210>  127
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2-Modified SP

<400>  127

Met Leu Ile Leu Leu Leu Met Leu Val Leu Leu Thr Phe Leu Ala Phe 
1               5                   10                  15      


Ala Ser Cys Cys 
            20  


<210>  128
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGF2-Modified SP

<400>  128
atgctgatcc tgctgctgat gctggtgctg ctgaccttcc tggccttcgc cagctgctgt       60


<210>  129
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.22

<400>  129
atgctgatcc tgctgctgat gctggtgctg ctgaccttcc tggccttcgc cagctgctgt       60

gtgaagatgc acaccatgag cagcagccac ctgttctatc tggccctgtg cctgctgaca      120

ttcaccagct ctgctaccgc cggacctgag acactttgtg gcgctgaact ggtggacgcc      180

ctgcagtttg tgtgtggcga cagaggcttc tacttcaaca agcccacagg ctacggcagc      240

agctctagaa gggctcctca gaccggaatc gtggacgagt gctgcttcag aagctgcgac      300

ctgcggcggc tggaaatgta ttgtgcccct ctgaagcctg ccaagagcgc ctaa            354


<210>  130
<211>  354
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.22


<220>
<221>  modified_base
<222>  (1)..(354)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  130
augcugaucc ugcugcugau gcuggugcug cugaccuucc uggccuucgc cagcugcugu       60

gugaagaugc acaccaugag cagcagccac cuguucuauc uggcccugug ccugcugaca      120

uucaccagcu cugcuaccgc cggaccugag acacuuugug gcgcugaacu gguggacgcc      180

cugcaguuug uguguggcga cagaggcuuc uacuucaaca agcccacagg cuacggcagc      240

agcucuagaa gggcuccuca gaccggaauc guggacgagu gcugcuucag aagcugcgac      300

cugcggcggc uggaaaugua uugugccccu cugaagccug ccaagagcgc cuaa            354


<210>  131
<211>  2734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-T with Cpd.22

<400>  131
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catgctgatc ctgctgctga tgctggtgct      420

gctgaccttc ctggccttcg ccagctgctg tgtgaagatg cacaccatga gcagcagcca      480

cctgttctat ctggccctgt gcctgctgac attcaccagc tctgctaccg ccggacctga      540

gacactttgt ggcgctgaac tggtggacgc cctgcagttt gtgtgtggcg acagaggctt      600

ctacttcaac aagcccacag gctacggcag cagctctaga agggctcctc agaccggaat      660

cgtggacgag tgctgcttca gaagctgcga cctgcggcgg ctggaaatgt attgtgcccc      720

tctgaagcct gccaagagcg cctaaggtac ctggagcaca agactggcct catgggcctt      780

ccgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aacatggtca      840

tagctgtttc cttgcgtatt gggcgctctc cgcttcctcg ctcactgact cgctgcgctc      900

ggtcgttcgg gtaaagcctg gggtgcctaa tgagcaaaag gccagcaaaa ggccaggaac      960

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     1020

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     1080

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     1140

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     1200

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     1260

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     1320

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     1380

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt     1440

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     1500

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     1560

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     1620

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     1680

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     1740

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     1800

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     1860

ggccccagtg ctgcaatgat accgcgagaa ccacgctcac cggctccaga tttatcagca     1920

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     1980

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     2040

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct     2100

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     2160

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     2220

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     2280

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     2340

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     2400

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     2460

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     2520

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     2580

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     2640

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     2700

ggggttccgc gcacatttcc ccgaaaagtg ccac                                 2734


<210>  132
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CXCL12-Modified SP

<400>  132

Met Ala Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu Cys Leu 
1               5                   10                  15      


Ser Asp Gly 
            


<210>  133
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CXCL12-Modified SP

<400>  133
atggccgtgg tggtggtgct ggtcctggtg ctgacagctc tgtgtctgtc cgacggc          57


<210>  134
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.23

<400>  134
atggccgtgg tggtggtgct ggtcctggtg ctgacagctc tgtgtctgtc cgacggcgtg       60

aagatgcaca ccatgagcag cagccacctg ttctatctgg ccctgtgcct gctgaccttt      120

accagctctg ctaccgccgg acctgagaca ctttgtggcg ctgaactggt ggacgccctg      180

cagtttgtgt gtggcgacag aggcttctac ttcaacaagc ccacaggcta cggcagcagc      240

tctagaaggg ctcctcagac cggaatcgtg gacgagtgct gcttcagaag ctgcgacctg      300

cggcggctgg aaatgtattg tgcccctctg aagcctgcca agagcgccta a               351


<210>  135
<211>  351
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.23


<220>
<221>  modified_base
<222>  (1)..(351)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  135
auggccgugg ugguggugcu gguccuggug cugacagcuc ugugucuguc cgacggcgug       60

aagaugcaca ccaugagcag cagccaccug uucuaucugg cccugugccu gcugaccuuu      120

accagcucug cuaccgccgg accugagaca cuuuguggcg cugaacuggu ggacgcccug      180

caguuugugu guggcgacag aggcuucuac uucaacaagc ccacaggcua cggcagcagc      240

ucuagaaggg cuccucagac cggaaucgug gacgagugcu gcuucagaag cugcgaccug      300

cggcggcugg aaauguauug ugccccucug aagccugcca agagcgccua a               351


<210>  136
<211>  2731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_pMA-T with Cpd.23

<400>  136
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catggccgtg gtggtggtgc tggtcctggt      420

gctgacagct ctgtgtctgt ccgacggcgt gaagatgcac accatgagca gcagccacct      480

gttctatctg gccctgtgcc tgctgacctt taccagctct gctaccgccg gacctgagac      540

actttgtggc gctgaactgg tggacgccct gcagtttgtg tgtggcgaca gaggcttcta      600

cttcaacaag cccacaggct acggcagcag ctctagaagg gctcctcaga ccggaatcgt      660

ggacgagtgc tgcttcagaa gctgcgacct gcggcggctg gaaatgtatt gtgcccctct      720

gaagcctgcc aagagcgcct aaggtacctg gagcacaaga ctggcctcat gggccttccg      780

ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaac atggtcatag      840

ctgtttcctt gcgtattggg cgctctccgc ttcctcgctc actgactcgc tgcgctcggt      900

cgttcgggta aagcctgggg tgcctaatga gcaaaaggcc agcaaaaggc caggaaccgt      960

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     1020

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     1080

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     1140

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     1200

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     1260

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     1320

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     1380

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     1440

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     1500

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     1560

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     1620

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     1680

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     1740

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     1800

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     1860

cccagtgctg caatgatacc gcgagaacca cgctcaccgg ctccagattt atcagcaata     1920

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     1980

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     2040

aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca     2100

ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa     2160

gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca     2220

ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt     2280

tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt     2340

tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg     2400

ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga     2460

tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc     2520

agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg     2580

acacggaaat gttgaatact catactcttc ctttttcaat attattgaag catttatcag     2640

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg     2700

gttccgcgca catttccccg aaaagtgcca c                                    2731


<210>  137
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDNF-Modified SP

<400>  137

Met Leu Ile Leu Phe Leu Leu Met Val Ile Leu Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala 
        


<210>  138
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BDNF-Modified SP

<400>  138
atgctgatcc tgtttctgct gatggtcatc ctgtacttcg gctgcatgaa ggcc             54


<210>  139
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.24

<400>  139
atgctgatcc tgtttctgct gatggtcatc ctgtacttcg gctgcatgaa ggccgtgaag       60

atgcacacca tgagcagcag ccacctgttc tatctggccc tgtgcctgct gacctttacc      120

agctctgcta ccgccggacc tgagacactt tgtggcgctg aactggtgga cgccctgcag      180

tttgtgtgtg gcgacagagg cttctacttc aacaagccca caggctacgg cagcagctct      240

agaagggctc ctcagaccgg aatcgtggac gagtgctgct tcagaagctg cgacctgcgg      300

cggctggaaa tgtattgtgc ccctctgaag cctgccaaga gcgcctaa                   348


<210>  140
<211>  348
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.24


<220>
<221>  modified_base
<222>  (1)..(348)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  140
augcugaucc uguuucugcu gauggucauc cuguacuucg gcugcaugaa ggccgugaag       60

augcacacca ugagcagcag ccaccuguuc uaucuggccc ugugccugcu gaccuuuacc      120

agcucugcua ccgccggacc ugagacacuu uguggcgcug aacuggugga cgcccugcag      180

uuugugugug gcgacagagg cuucuacuuc aacaagccca caggcuacgg cagcagcucu      240

agaagggcuc cucagaccgg aaucguggac gagugcugcu ucagaagcug cgaccugcgg      300

cggcuggaaa uguauugugc cccucugaag ccugccaaga gcgccuaa                   348


<210>  141
<211>  2728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_pMA-T with Cpd.24

<400>  141
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catgctgatc ctgtttctgc tgatggtcat      420

cctgtacttc ggctgcatga aggccgtgaa gatgcacacc atgagcagca gccacctgtt      480

ctatctggcc ctgtgcctgc tgacctttac cagctctgct accgccggac ctgagacact      540

ttgtggcgct gaactggtgg acgccctgca gtttgtgtgt ggcgacagag gcttctactt      600

caacaagccc acaggctacg gcagcagctc tagaagggct cctcagaccg gaatcgtgga      660

cgagtgctgc ttcagaagct gcgacctgcg gcggctggaa atgtattgtg cccctctgaa      720

gcctgccaag agcgcctaag gtacctggag cacaagactg gcctcatggg ccttccgctc      780

actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaacatg gtcatagctg      840

tttccttgcg tattgggcgc tctccgcttc ctcgctcact gactcgctgc gctcggtcgt      900

tcgggtaaag cctggggtgc ctaatgagca aaaggccagc aaaaggccag gaaccgtaaa      960

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     1020

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     1080

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     1140

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     1200

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     1260

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     1320

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     1380

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc     1440

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa     1500

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa     1560

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac     1620

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta     1680

aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt     1740

taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata     1800

gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc     1860

agtgctgcaa tgataccgcg agaaccacgc tcaccggctc cagatttatc agcaataaac     1920

cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag     1980

tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac     2040

gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc     2100

agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg     2160

gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc     2220

atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct     2280

gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc     2340

tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc     2400

atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc     2460

agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc     2520

gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca     2580

cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt     2640

tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt     2700

ccgcgcacat ttccccgaaa agtgccac                                        2728


<210>  142
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1Pro-Modified SP

<400>  142

Met Leu Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala 
1               5                   10                  15      


Thr Ala 
        


<210>  143
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGF1Pro-Modified SP

<400>  143
atgctgttct atctggccct gtgcctgctg acctttacca gctctgctac cgcc             54


<210>  144
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.25

<400>  144
atgctgttct atctggccct gtgcctgctg acctttacca gctctgctac cgccggacct       60

gagacacttt gtggcgctga actggtggac gccctgcagt ttgtgtgtgg cgacagaggc      120

ttctacttca acaagcccac aggctacggc agcagctcta gaagggctcc tcagaccgga      180

atcgtggacg agtgctgctt cagaagctgc gacctgcggc ggctggaaat gtattgtgcc      240

cctctgaagc ctgccaagag cgcctaa                                          267


<210>  145
<211>  267
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.25


<220>
<221>  modified_base
<222>  (1)..(267)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  145
augcuguucu aucuggcccu gugccugcug accuuuacca gcucugcuac cgccggaccu       60

gagacacuuu guggcgcuga acugguggac gcccugcagu uugugugugg cgacagaggc      120

uucuacuuca acaagcccac aggcuacggc agcagcucua gaagggcucc ucagaccgga      180

aucguggacg agugcugcuu cagaagcugc gaccugcggc ggcuggaaau guauugugcc      240

ccucugaagc cugccaagag cgccuaa                                          267


<210>  146
<211>  2647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_pMA-T with Cpd.25

<400>  146
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catgctgttc tatctggccc tgtgcctgct      420

gacctttacc agctctgcta ccgccggacc tgagacactt tgtggcgctg aactggtgga      480

cgccctgcag tttgtgtgtg gcgacagagg cttctacttc aacaagccca caggctacgg      540

cagcagctct agaagggctc ctcagaccgg aatcgtggac gagtgctgct tcagaagctg      600

cgacctgcgg cggctggaaa tgtattgtgc ccctctgaag cctgccaaga gcgcctaagg      660

tacctggagc acaagactgg cctcatgggc cttccgctca ctgcccgctt tccagtcggg      720

aaacctgtcg tgccagctgc attaacatgg tcatagctgt ttccttgcgt attgggcgct      780

ctccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cgggtaaagc ctggggtgcc      840

taatgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      900

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      960

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc     1020

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc     1080

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc     1140

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac     1200

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt     1260

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct     1320

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc     1380

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt     1440

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg     1500

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc     1560

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa     1620

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1680

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1740

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1800

gaaccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1860

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1920

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1980

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     2040

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     2100

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     2160

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     2220

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     2280

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     2340

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     2400

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     2460

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     2520

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     2580

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     2640

gtgccac                                                               2647


<210>  147
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  INS-Modified SP

<400>  147

Met Ala Leu Trp Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly 
1               5                   10                  15      


Pro Asp Pro Ala Ala Ala 
            20          


<210>  148
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INS-Modified SP

<400>  148
atggctctgt ggctgctgcc tctgctggca ctgcttgctc tgtggggacc tgatcctgcc       60

gccgct                                                                  66


<210>  149
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.26

<400>  149
atggctctgt ggctgctgcc tctgctggca ctgcttgctc tgtggggacc tgatcctgcc       60

gccgctgtga agatgcacac aatgagcagc agccacctgt tctatctggc cctgtgcctg      120

ctgaccttta ccagctctgc taccgccgga cctgagacac tttgtggcgc tgaactggtg      180

gacgccctgc agtttgtgtg tggcgacaga ggcttctact tcaacaagcc cacaggctac      240

ggcagcagct ctagaagggc tcctcagacc ggaatcgtgg acgagtgctg cttcagaagc      300

tgcgacctgc ggcggctgga aatgtattgt gcccctctga agcctgccaa gagcgcctaa      360


<210>  150
<211>  360
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.26


<220>
<221>  modified_base
<222>  (1)..(360)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  150
auggcucugu ggcugcugcc ucugcuggca cugcuugcuc uguggggacc ugauccugcc       60

gccgcuguga agaugcacac aaugagcagc agccaccugu ucuaucuggc ccugugccug      120

cugaccuuua ccagcucugc uaccgccgga ccugagacac uuuguggcgc ugaacuggug      180

gacgcccugc aguuugugug uggcgacaga ggcuucuacu ucaacaagcc cacaggcuac      240

ggcagcagcu cuagaagggc uccucagacc ggaaucgugg acgagugcug cuucagaagc      300

ugcgaccugc ggcggcugga aauguauugu gccccucuga agccugccaa gagcgccuaa      360


<210>  151
<211>  2740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_pMA-T with Cpd.26

<400>  151
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catggctctg tggctgctgc ctctgctggc      420

actgcttgct ctgtggggac ctgatcctgc cgccgctgtg aagatgcaca caatgagcag      480

cagccacctg ttctatctgg ccctgtgcct gctgaccttt accagctctg ctaccgccgg      540

acctgagaca ctttgtggcg ctgaactggt ggacgccctg cagtttgtgt gtggcgacag      600

aggcttctac ttcaacaagc ccacaggcta cggcagcagc tctagaaggg ctcctcagac      660

cggaatcgtg gacgagtgct gcttcagaag ctgcgacctg cggcggctgg aaatgtattg      720

tgcccctctg aagcctgcca agagcgccta aggtacctgg agcacaagac tggcctcatg      780

ggccttccgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaaca      840

tggtcatagc tgtttccttg cgtattgggc gctctccgct tcctcgctca ctgactcgct      900

gcgctcggtc gttcgggtaa agcctggggt gcctaatgag caaaaggcca gcaaaaggcc      960

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     1020

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     1080

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     1140

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt     1200

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc     1260

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga     1320

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta     1380

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta     1440

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga     1500

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg     1560

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag     1620

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc     1680

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact     1740

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt     1800

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta     1860

ccatctggcc ccagtgctgc aatgataccg cgagaaccac gctcaccggc tccagattta     1920

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc     1980

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat     2040

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt     2100

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg     2160

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca     2220

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta     2280

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg     2340

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact     2400

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg     2460

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt     2520

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga     2580

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc     2640

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa     2700

caaatagggg ttccgcgcac atttccccga aaagtgccac                           2740


<210>  152
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epo-Modified SP

<400>  152

Met Leu Val Cys Leu Ala Leu Leu Leu Leu Leu Ser Leu Leu Ser Leu 
1               5                   10                  15      


Pro Leu Gly Leu Pro Val Leu Gly 
            20                  


<210>  153
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Epo-Modified SP

<400>  153
atgcttgtgt gtctggctct gctgctgctc ctgagcctgc tgtctctgcc tctgggactg       60

cctgttcttg ga                                                           72


<210>  154
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.28

<400>  154
atgcttgtgt gtctggctct gctgctgctc ctgagcctgc tgtctctgcc tctgggactg       60

cctgttcttg gagcccctcc tagactgatc tgcgacagca gagtgctgga aagatacctg      120

ctggaagcca aagaggccga gaacatcacc acaggctgtg ccgagcactg cagcctgaac      180

gagaatatca ccgtgcctga caccaaagtg aacttctacg cctggaagcg gatggaagtg      240

ggccagcagg ctgtggaagt ttggcaagga ctggccctgc tgagcgaagc tgttctgaga      300

ggacaggctc tgctcgtgaa cagctctcag ccttgggaac ctctgcaact gcacgtggac      360

aaggccgtgt ctggcctgag aagcctgacc acactgctga gagcactggg agcccagaaa      420

gaggccatct ctccacctga tgctgcctct gctgcccctc tgagaaccat caccgccgac      480

accttcagaa agctgttccg ggtgtacagc aacttcctgc ggggcaagct gaagctgtac      540

acaggcgagg cttgcagaac cggcgacaga taa                                   573


<210>  155
<211>  573
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.28


<220>
<221>  modified_base
<222>  (1)..(573)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  155
augcuugugu gucuggcucu gcugcugcuc cugagccugc ugucucugcc ucugggacug       60

ccuguucuug gagccccucc uagacugauc ugcgacagca gagugcugga aagauaccug      120

cuggaagcca aagaggccga gaacaucacc acaggcugug ccgagcacug cagccugaac      180

gagaauauca ccgugccuga caccaaagug aacuucuacg ccuggaagcg gauggaagug      240

ggccagcagg cuguggaagu uuggcaagga cuggcccugc ugagcgaagc uguucugaga      300

ggacaggcuc ugcucgugaa cagcucucag ccuugggaac cucugcaacu gcacguggac      360

aaggccgugu cuggccugag aagccugacc acacugcuga gagcacuggg agcccagaaa      420

gaggccaucu cuccaccuga ugcugccucu gcugccccuc ugagaaccau caccgccgac      480

accuucagaa agcuguuccg gguguacagc aacuuccugc ggggcaagcu gaagcuguac      540

acaggcgagg cuugcagaac cggcgacaga uaa                                   573


<210>  156
<211>  2953
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_pMA-T with Cpd.28

<400>  156
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catgcttgtg tgtctggctc tgctgctgct      420

cctgagcctg ctgtctctgc ctctgggact gcctgttctt ggagcccctc ctagactgat      480

ctgcgacagc agagtgctgg aaagatacct gctggaagcc aaagaggccg agaacatcac      540

cacaggctgt gccgagcact gcagcctgaa cgagaatatc accgtgcctg acaccaaagt      600

gaacttctac gcctggaagc ggatggaagt gggccagcag gctgtggaag tttggcaagg      660

actggccctg ctgagcgaag ctgttctgag aggacaggct ctgctcgtga acagctctca      720

gccttgggaa cctctgcaac tgcacgtgga caaggccgtg tctggcctga gaagcctgac      780

cacactgctg agagcactgg gagcccagaa agaggccatc tctccacctg atgctgcctc      840

tgctgcccct ctgagaacca tcaccgccga caccttcaga aagctgttcc gggtgtacag      900

caacttcctg cggggcaagc tgaagctgta cacaggcgag gcttgcagaa ccggcgacag      960

ataaggtacc tggagcacaa gactggcctc atgggccttc cgctcactgc ccgctttcca     1020

gtcgggaaac ctgtcgtgcc agctgcatta acatggtcat agctgtttcc ttgcgtattg     1080

ggcgctctcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggg taaagcctgg     1140

ggtgcctaat gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     1200

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     1260

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     1320

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     1380

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     1440

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     1500

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     1560

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     1620

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     1680

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     1740

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     1800

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     1860

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     1920

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     1980

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc     2040

gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata     2100

ccgcgagaac cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg     2160

gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc     2220

cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct     2280

acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa     2340

cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt     2400

cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca     2460

ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac     2520

tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca     2580

atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt     2640

tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc     2700

actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca     2760

aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata     2820

ctcatactct tcctttttca atattattga agcatttatc agggttattg tctcatgagc     2880

ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc     2940

cgaaaagtgc cac                                                        2953


<210>  157
<211>  555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.29

<400>  157
atgaccatcc tgtttctgac aatggtcatc agctacttcg gctgcatgaa ggccgctcct       60

ccaagactga tctgcgacag cagagtgctg gaaagatacc tgctggaagc caaagaggcc      120

gagaacatca ccacaggctg tgccgagcac tgcagcctga acgagaatat caccgtgcct      180

gacaccaaag tgaacttcta cgcctggaag cggatggaag tgggccagca ggctgtggaa      240

gtttggcaag gactggccct gctgtctgag gctgttctga gaggacaggc tctgctggtc      300

aacagctctc agccttggga acctctgcaa ctgcacgtgg acaaggccgt gtctggcctg      360

agaagcctga ccacactgct gagagcactg ggagcccaga aagaggccat ctctccacct      420

gatgctgcct ctgctgcccc tctgagaacc atcaccgccg acaccttcag aaagctgttc      480

cgggtgtaca gcaacttcct gcggggcaag ctgaagctgt acacaggcga ggcttgcaga      540

accggcgaca gataa                                                       555


<210>  158
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.29


<220>
<221>  modified_base
<222>  (1)..(555)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  158
augaccaucc uguuucugac aauggucauc agcuacuucg gcugcaugaa ggccgcuccu       60

ccaagacuga ucugcgacag cagagugcug gaaagauacc ugcuggaagc caaagaggcc      120

gagaacauca ccacaggcug ugccgagcac ugcagccuga acgagaauau caccgugccu      180

gacaccaaag ugaacuucua cgccuggaag cggauggaag ugggccagca ggcuguggaa      240

guuuggcaag gacuggcccu gcugucugag gcuguucuga gaggacaggc ucugcugguc      300

aacagcucuc agccuuggga accucugcaa cugcacgugg acaaggccgu gucuggccug      360

agaagccuga ccacacugcu gagagcacug ggagcccaga aagaggccau cucuccaccu      420

gaugcugccu cugcugcccc ucugagaacc aucaccgccg acaccuucag aaagcuguuc      480

cggguguaca gcaacuuccu gcggggcaag cugaagcugu acacaggcga ggcuugcaga      540

accggcgaca gauaa                                                       555


<210>  159
<211>  2902
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_pMA-RQ with Cpd.29

<400>  159
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatgac catcctgttt ctgacaatgg tcatcagcta cttcggctgc      420

atgaaggccg ctcctccaag actgatctgc gacagcagag tgctggaaag atacctgctg      480

gaagccaaag aggccgagaa catcaccaca ggctgtgccg agcactgcag cctgaacgag      540

aatatcaccg tgcctgacac caaagtgaac ttctacgcct ggaagcggat ggaagtgggc      600

cagcaggctg tggaagtttg gcaaggactg gccctgctgt ctgaggctgt tctgagagga      660

caggctctgc tggtcaacag ctctcagcct tgggaacctc tgcaactgca cgtggacaag      720

gccgtgtctg gcctgagaag cctgaccaca ctgctgagag cactgggagc ccagaaagag      780

gccatctctc cacctgatgc tgcctctgct gcccctctga gaaccatcac cgccgacacc      840

ttcagaaagc tgttccgggt gtacagcaac ttcctgcggg gcaagctgaa gctgtacaca      900

ggcgaggctt gcagaaccgg cgacagataa ctgggcctca tgggccttcc gctcactgcc      960

cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa catggtcata gctgtttcct     1020

tgcgtattgg gcgctctccg cttcctcgct cactgactcg ctgcgctcgg tcgttcgggt     1080

aaagcctggg gtgcctaatg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc     1140

gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc     1200

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga     1260

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt     1320

ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg     1380

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc     1440

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg     1500

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc     1560

ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg     1620

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc     1680

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct     1740

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt     1800

taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa     1860

aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa     1920

tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc     1980

tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct     2040

gcaatgatac cgcgagaacc acgctcaccg gctccagatt tatcagcaat aaaccagcca     2100

gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt     2160

aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt     2220

gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     2280

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     2340

tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt     2400

atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact     2460

ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc     2520

ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt     2580

ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg     2640

atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct     2700

gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa     2760

tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     2820

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     2880

acatttcccc gaaaagtgcc ac                                              2902


<210>  160
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.31

<400>  160
atggcacttt ggctgctgcc tcttctggct ctgctggctc tttggggacc tgatcctgcc       60

gccgctttcg tgaatcagca cctgtgtggc agccacctgg tggaagccct gtatctcgtg      120

tgtggcgagc ggggcttctt ctacacccct aagacaagaa gagaggccga ggacctgcaa      180

gtcggccagg ttgaacttgg cggaggacct ggtgctggat ctctgcaacc tctggcactg      240

gaaggcagcc tgcagaagag gggcatcgtc gagcagtgct gcaccagcat ctgtagcctg      300

taccagctgg aaaactactg caactga                                          327


<210>  161
<211>  327
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.31


<220>
<221>  modified_base
<222>  (1)..(327)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  161
auggcacuuu ggcugcugcc ucuucuggcu cugcuggcuc uuuggggacc ugauccugcc       60

gccgcuuucg ugaaucagca ccuguguggc agccaccugg uggaagcccu guaucucgug      120

uguggcgagc ggggcuucuu cuacaccccu aagacaagaa gagaggccga ggaccugcaa      180

gucggccagg uugaacuugg cggaggaccu ggugcuggau cucugcaacc ucuggcacug      240

gaaggcagcc ugcagaagag gggcaucguc gagcagugcu gcaccagcau cuguagccug      300

uaccagcugg aaaacuacug caacuga                                          327


<210>  162
<211>  2707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_pMA-T with Cpd.31

<400>  162
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catggcactt tggctgctgc ctcttctggc      420

tctgctggct ctttggggac ctgatcctgc cgccgctttc gtgaatcagc acctgtgtgg      480

cagccacctg gtggaagccc tgtatctcgt gtgtggcgag cggggcttct tctacacccc      540

taagacaaga agagaggccg aggacctgca agtcggccag gttgaacttg gcggaggacc      600

tggtgctgga tctctgcaac ctctggcact ggaaggcagc ctgcagaaga ggggcatcgt      660

cgagcagtgc tgcaccagca tctgtagcct gtaccagctg gaaaactact gcaactgagg      720

tacctggagc acaagactgg cctcatgggc cttccgctca ctgcccgctt tccagtcggg      780

aaacctgtcg tgccagctgc attaacatgg tcatagctgt ttccttgcgt attgggcgct      840

ctccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cgggtaaagc ctggggtgcc      900

taatgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      960

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg     1020

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc     1080

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc     1140

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc     1200

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac     1260

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt     1320

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct     1380

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc     1440

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt     1500

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg     1560

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc     1620

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa     1680

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1740

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1800

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1860

gaaccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1920

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1980

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     2040

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     2100

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     2160

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     2220

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     2280

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     2340

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     2400

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     2460

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     2520

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     2580

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     2640

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     2700

gtgccac                                                               2707


<210>  163
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.32

<400>  163
atgaccatcc tgtttctgac aatggtcatc agctacttcg gctgcatgaa ggcctttgtg       60

aaccagcacc tgtgcggcag ccatctggtg gaagccctgt atctcgtgtg tggcgagcgg      120

ggcttcttct acacccctaa gacaagaaga gaggccgagg acctgcaagt cggccaggtt      180

gaacttggcg gaggacctgg tgctggatct ctgcaacctc tggctctgga aggcagcctg      240

cagaagaggg gcatcgtcga gcagtgctgc accagcatct gtagcctgta ccagctggaa      300

aactactgca actga                                                       315


<210>  164
<211>  315
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.32


<220>
<221>  modified_base
<222>  (1)..(315)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  164
augaccaucc uguuucugac aauggucauc agcuacuucg gcugcaugaa ggccuuugug       60

aaccagcacc ugugcggcag ccaucuggug gaagcccugu aucucgugug uggcgagcgg      120

ggcuucuucu acaccccuaa gacaagaaga gaggccgagg accugcaagu cggccagguu      180

gaacuuggcg gaggaccugg ugcuggaucu cugcaaccuc uggcucugga aggcagccug      240

cagaagaggg gcaucgucga gcagugcugc accagcaucu guagccugua ccagcuggaa      300

aacuacugca acuga                                                       315


<210>  165
<211>  2662
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.32

<400>  165
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatgac catcctgttt ctgacaatgg tcatcagcta cttcggctgc      420

atgaaggcct ttgtgaacca gcacctgtgc ggcagccatc tggtggaagc cctgtatctc      480

gtgtgtggcg agcggggctt cttctacacc cctaagacaa gaagagaggc cgaggacctg      540

caagtcggcc aggttgaact tggcggagga cctggtgctg gatctctgca acctctggct      600

ctggaaggca gcctgcagaa gaggggcatc gtcgagcagt gctgcaccag catctgtagc      660

ctgtaccagc tggaaaacta ctgcaactga ctgggcctca tgggccttcc gctcactgcc      720

cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa catggtcata gctgtttcct      780

tgcgtattgg gcgctctccg cttcctcgct cactgactcg ctgcgctcgg tcgttcgggt      840

aaagcctggg gtgcctaatg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc      900

gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc      960

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga     1020

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt     1080

ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg     1140

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc     1200

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg     1260

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc     1320

ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg     1380

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc     1440

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct     1500

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt     1560

taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa     1620

aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa     1680

tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc     1740

tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct     1800

gcaatgatac cgcgagaacc acgctcaccg gctccagatt tatcagcaat aaaccagcca     1860

gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt     1920

aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt     1980

gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     2040

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     2100

tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt     2160

atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact     2220

ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc     2280

ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt     2340

ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg     2400

atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct     2460

gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa     2520

tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     2580

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     2640

acatttcccc gaaaagtgcc ac                                              2662


<210>  166
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL4-Modified SP

<400>  166

Met Leu Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala Cys Ala Gly Asn 
1               5                   10                  15      


Phe Val His Gly 
            20  


<210>  167
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL4-Modified SP

<400>  167
atgttgttgc tgcctccact gttctttctg ctggcctgcg ccggcaattt tgtgcacggc       60


<210>  168
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.34

<400>  168
atgttgttgc tgcctccact gttctttctg ctggcctgcg ccggcaattt tgtgcacggc       60

cacaagtgcg acatcaccct gcaagagatc atcaagaccc tgaacagcct gaccgagcag      120

aaaaccctgt gcaccgagct gaccgtgacc gatatctttg ccgccagcaa gaacacaacc      180

gagaaagaga cattctgcag agccgccacc gtgctgagac agttctacag ccaccacgag      240

aaggacacca gatgcctggg agctacagcc cagcagttcc acagacacaa gcagctgatc      300

cggttcctga agcggctgga cagaaatctg tggggactcg ccggcctgaa tagctgccct      360

gtgaaagagg ccaaccagtc taccctggaa aacttcctgg aacggctgaa aaccatcatg      420

cgcgagaagt acagcaagtg cagcagctga                                       450


<210>  169
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.34


<220>
<221>  modified_base
<222>  (1)..(450)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  169
auguuguugc ugccuccacu guucuuucug cuggccugcg ccggcaauuu ugugcacggc       60

cacaagugcg acaucacccu gcaagagauc aucaagaccc ugaacagccu gaccgagcag      120

aaaacccugu gcaccgagcu gaccgugacc gauaucuuug ccgccagcaa gaacacaacc      180

gagaaagaga cauucugcag agccgccacc gugcugagac aguucuacag ccaccacgag      240

aaggacacca gaugccuggg agcuacagcc cagcaguucc acagacacaa gcagcugauc      300

cgguuccuga agcggcugga cagaaaucug uggggacucg ccggccugaa uagcugcccu      360

gugaaagagg ccaaccaguc uacccuggaa aacuuccugg aacggcugaa aaccaucaug      420

cgcgagaagu acagcaagug cagcagcuga                                       450


<210>  170
<211>  2830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-T with Cpd.34

<400>  170
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catgttgttg ctgcctccac tgttctttct      420

gctggcctgc gccggcaatt ttgtgcacgg ccacaagtgc gacatcaccc tgcaagagat      480

catcaagacc ctgaacagcc tgaccgagca gaaaaccctg tgcaccgagc tgaccgtgac      540

cgatatcttt gccgccagca agaacacaac cgagaaagag acattctgca gagccgccac      600

cgtgctgaga cagttctaca gccaccacga gaaggacacc agatgcctgg gagctacagc      660

ccagcagttc cacagacaca agcagctgat ccggttcctg aagcggctgg acagaaatct      720

gtggggactc gccggcctga atagctgccc tgtgaaagag gccaaccagt ctaccctgga      780

aaacttcctg gaacggctga aaaccatcat gcgcgagaag tacagcaagt gcagcagctg      840

aggtacctgg agcacaagac tggcctcatg ggccttccgc tcactgcccg ctttccagtc      900

gggaaacctg tcgtgccagc tgcattaaca tggtcatagc tgtttccttg cgtattgggc      960

gctctccgct tcctcgctca ctgactcgct gcgctcggtc gttcgggtaa agcctggggt     1020

gcctaatgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg     1080

tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg     1140

tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg     1200

cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga     1260

agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc     1320

tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt     1380

aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact     1440

ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg     1500

cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt     1560

accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt     1620

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct     1680

ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg     1740

gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt     1800

aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt     1860

gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc     1920

gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg     1980

cgagaaccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc     2040

gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg     2100

gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca     2160

ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga     2220

tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct     2280

ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg     2340

cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca     2400

accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata     2460

cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct     2520

tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact     2580

cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa     2640

acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc     2700

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga     2760

tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga     2820

aaagtgccac                                                            2830


<210>  171
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.35

<400>  171
atgagcctga gctttctgct gctgctgttc ttcagccacc tgatcctgtc tgcctgggct       60

cacaagtgcg acatcaccct gcaagagatc atcaagaccc tgaacagcct gaccgagcag      120

aaaaccctgt gcaccgagct gaccgtgacc gatatctttg ccgccagcaa gaacacaacc      180

gagaaagaga cattctgcag agccgccacc gtgctgagac agttctactc ccaccacgag      240

aaggacacca gatgcctggg agctacagcc cagcagttcc acagacacaa gcagctgatc      300

cggttcctga agcggctgga cagaaatctg tggggactcg ccggcctgaa tagctgccct      360

gtgaaagagg ccaaccagtc taccctggaa aacttcctgg aacggctgaa aaccatcatg      420

cgcgagaagt acagcaagtg cagcagctga                                       450


<210>  172
<211>  450
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.35


<220>
<221>  modified_base
<222>  (1)..(450)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  172
augagccuga gcuuucugcu gcugcuguuc uucagccacc ugauccuguc ugccugggcu       60

cacaagugcg acaucacccu gcaagagauc aucaagaccc ugaacagccu gaccgagcag      120

aaaacccugu gcaccgagcu gaccgugacc gauaucuuug ccgccagcaa gaacacaacc      180

gagaaagaga cauucugcag agccgccacc gugcugagac aguucuacuc ccaccacgag      240

aaggacacca gaugccuggg agcuacagcc cagcaguucc acagacacaa gcagcugauc      300

cgguuccuga agcggcugga cagaaaucug uggggacucg ccggccugaa uagcugcccu      360

gugaaagagg ccaaccaguc uacccuggaa aacuuccugg aacggcugaa aaccaucaug      420

cgcgagaagu acagcaagug cagcagcuga                                       450


<210>  173
<211>  2797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.35

<400>  173
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatgag cctgagcttt ctgctgctgc tgttcttcag ccacctgatc      420

ctgtctgcct gggctcacaa gtgcgacatc accctgcaag agatcatcaa gaccctgaac      480

agcctgaccg agcagaaaac cctgtgcacc gagctgaccg tgaccgatat ctttgccgcc      540

agcaagaaca caaccgagaa agagacattc tgcagagccg ccaccgtgct gagacagttc      600

tactcccacc acgagaagga caccagatgc ctgggagcta cagcccagca gttccacaga      660

cacaagcagc tgatccggtt cctgaagcgg ctggacagaa atctgtgggg actcgccggc      720

ctgaatagct gccctgtgaa agaggccaac cagtctaccc tggaaaactt cctggaacgg      780

ctgaaaacca tcatgcgcga gaagtacagc aagtgcagca gctgactggg cctcatgggc      840

cttccgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaacatgg      900

tcatagctgt ttccttgcgt attgggcgct ctccgcttcc tcgctcactg actcgctgcg      960

ctcggtcgtt cgggtaaagc ctggggtgcc taatgagcaa aaggccagca aaaggccagg     1020

aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat     1080

cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag     1140

gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga     1200

tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg     1260

tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt     1320

cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac     1380

gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc     1440

ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt     1500

ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc     1560

ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc     1620

agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg     1680

aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag     1740

atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg     1800

tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt     1860

tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca     1920

tctggcccca gtgctgcaat gataccgcga gaaccacgct caccggctcc agatttatca     1980

gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc     2040

tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt     2100

ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg     2160

gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc     2220

aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg     2280

ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga     2340

tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga     2400

ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta     2460

aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg     2520

ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact     2580

ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata     2640

agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt     2700

tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa     2760

ataggggttc cgcgcacatt tccccgaaaa gtgccac                              2797


<210>  174
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL10-Modified SP

<400>  174

Met Val Leu Leu Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala 
        


<210>  175
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL10-Modified SP

<400>  175
atggttctgc tggctctgct gtgttgtctg gtgctgctga caggcgtcag agcc             54


<210>  176
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.37

<400>  176
atggttctgc tggctctgct gtgttgtctg gtgctgctga caggcgtcag agcctctcct       60

ggacagggaa cccagagcga gaatagctgc acccactttc caggcaacct gcctaacatg      120

ctgcgggacc tgagagatgc cttcagcaga gtgaaaacat tcttccagat gaaggaccag      180

ctggacaacc tgctgctgaa agagagcctg ctggaagatt tcaagggcta cctgggctgt      240

caggccctga gcgagatgat ccagttctac ctggaagaag tgatgcccca ggccgagaat      300

caggaccccg atattaaggc ccacgtgaac agcctgggcg agaacctgaa aaccctgcgg      360

ctgagactgc ggcggtgcca cagatttctg ccctgcgaga acaagagcaa ggccgtggaa      420

caagtgaaga acgccttcaa caagctgcaa gagaagggca tctacaaggc catgtccgag      480

ttcgacatct tcatcaacta catcgaggcc tacatgacca tgaagatccg gaactga         537


<210>  177
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.37


<220>
<221>  modified_base
<222>  (1)..(537)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  177
augguucugc uggcucugcu guguugucug gugcugcuga caggcgucag agccucuccu       60

ggacagggaa cccagagcga gaauagcugc acccacuuuc caggcaaccu gccuaacaug      120

cugcgggacc ugagagaugc cuucagcaga gugaaaacau ucuuccagau gaaggaccag      180

cuggacaacc ugcugcugaa agagagccug cuggaagauu ucaagggcua ccugggcugu      240

caggcccuga gcgagaugau ccaguucuac cuggaagaag ugaugcccca ggccgagaau      300

caggaccccg auauuaaggc ccacgugaac agccugggcg agaaccugaa aacccugcgg      360

cugagacugc ggcggugcca cagauuucug cccugcgaga acaagagcaa ggccguggaa      420

caagugaaga acgccuucaa caagcugcaa gagaagggca ucuacaaggc cauguccgag      480

uucgacaucu ucaucaacua caucgaggcc uacaugacca ugaagauccg gaacuga         537


<210>  178
<211>  2917
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-T with Cpd.37

<400>  178
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catggttctg ctggctctgc tgtgttgtct      420

ggtgctgctg acaggcgtca gagcctctcc tggacaggga acccagagcg agaatagctg      480

cacccacttt ccaggcaacc tgcctaacat gctgcgggac ctgagagatg ccttcagcag      540

agtgaaaaca ttcttccaga tgaaggacca gctggacaac ctgctgctga aagagagcct      600

gctggaagat ttcaagggct acctgggctg tcaggccctg agcgagatga tccagttcta      660

cctggaagaa gtgatgcccc aggccgagaa tcaggacccc gatattaagg cccacgtgaa      720

cagcctgggc gagaacctga aaaccctgcg gctgagactg cggcggtgcc acagatttct      780

gccctgcgag aacaagagca aggccgtgga acaagtgaag aacgccttca acaagctgca      840

agagaagggc atctacaagg ccatgtccga gttcgacatc ttcatcaact acatcgaggc      900

ctacatgacc atgaagatcc ggaactgagg tacctggagc acaagactgg cctcatgggc      960

cttccgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaacatgg     1020

tcatagctgt ttccttgcgt attgggcgct ctccgcttcc tcgctcactg actcgctgcg     1080

ctcggtcgtt cgggtaaagc ctggggtgcc taatgagcaa aaggccagca aaaggccagg     1140

aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat     1200

cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag     1260

gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga     1320

tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg     1380

tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt     1440

cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac     1500

gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc     1560

ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt     1620

ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc     1680

ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc     1740

agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg     1800

aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag     1860

atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg     1920

tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt     1980

tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca     2040

tctggcccca gtgctgcaat gataccgcga gaaccacgct caccggctcc agatttatca     2100

gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc     2160

tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt     2220

ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg     2280

gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc     2340

aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg     2400

ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga     2460

tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga     2520

ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta     2580

aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg     2640

ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact     2700

ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata     2760

agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt     2820

tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa     2880

ataggggttc cgcgcacatt tccccgaaaa gtgccac                              2917


<210>  179
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.38

<400>  179
atgaccatcc tgtttctgac aatggtcatc agctacttcg gctgcatgaa ggcctctcca       60

ggccagggaa cacagagcga gaatagctgc acccactttc caggcaacct gcctaacatg      120

ctgcgggacc tgagagatgc cttctccaga gtgaaaacat tcttccagat gaaggaccag      180

ctggacaacc tgctgctgaa agagagcctg ctggaagatt tcaagggcta cctgggctgt      240

caggccctga gcgagatgat ccagttctac ctggaagaag tgatgcccca ggccgagaat      300

caggaccccg atattaaggc ccacgtgaac agcctgggcg agaacctgaa aaccctgcgg      360

ctgagactgc ggcggtgcca cagatttctg ccctgcgaga acaagagcaa ggccgtggaa      420

caagtgaaga acgccttcaa caagctgcaa gagaagggca tctacaaggc catgtccgag      480

ttcgacatct tcatcaacta catcgaggcc tacatgacca tgaagatccg gaactga         537


<210>  180
<211>  537
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.38


<220>
<221>  modified_base
<222>  (1)..(537)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  180
augaccaucc uguuucugac aauggucauc agcuacuucg gcugcaugaa ggccucucca       60

ggccagggaa cacagagcga gaauagcugc acccacuuuc caggcaaccu gccuaacaug      120

cugcgggacc ugagagaugc cuucuccaga gugaaaacau ucuuccagau gaaggaccag      180

cuggacaacc ugcugcugaa agagagccug cuggaagauu ucaagggcua ccugggcugu      240

caggcccuga gcgagaugau ccaguucuac cuggaagaag ugaugcccca ggccgagaau      300

caggaccccg auauuaaggc ccacgugaac agccugggcg agaaccugaa aacccugcgg      360

cugagacugc ggcggugcca cagauuucug cccugcgaga acaagagcaa ggccguggaa      420

caagugaaga acgccuucaa caagcugcaa gagaagggca ucuacaaggc cauguccgag      480

uucgacaucu ucaucaacua caucgaggcc uacaugacca ugaagauccg gaacuga         537


<210>  181
<211>  2884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-RQ with Cpd.38

<400>  181
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccgcatg ccaccatgac catcctgttt ctgacaatgg tcatcagcta cttcggctgc      420

atgaaggcct ctccaggcca gggaacacag agcgagaata gctgcaccca ctttccaggc      480

aacctgccta acatgctgcg ggacctgaga gatgccttct ccagagtgaa aacattcttc      540

cagatgaagg accagctgga caacctgctg ctgaaagaga gcctgctgga agatttcaag      600

ggctacctgg gctgtcaggc cctgagcgag atgatccagt tctacctgga agaagtgatg      660

ccccaggccg agaatcagga ccccgatatt aaggcccacg tgaacagcct gggcgagaac      720

ctgaaaaccc tgcggctgag actgcggcgg tgccacagat ttctgccctg cgagaacaag      780

agcaaggccg tggaacaagt gaagaacgcc ttcaacaagc tgcaagagaa gggcatctac      840

aaggccatgt ccgagttcga catcttcatc aactacatcg aggcctacat gaccatgaag      900

atccggaact gactgggcct catgggcctt ccgctcactg cccgctttcc agtcgggaaa      960

cctgtcgtgc cagctgcatt aacatggtca tagctgtttc cttgcgtatt gggcgctctc     1020

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg gtaaagcctg gggtgcctaa     1080

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     1140

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     1200

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     1260

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     1320

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     1380

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     1440

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     1500

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     1560

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc     1620

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     1680

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     1740

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     1800

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     1860

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     1920

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     1980

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagaa     2040

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     2100

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     2160

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     2220

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     2280

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     2340

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     2400

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     2460

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     2520

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     2580

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     2640

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     2700

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     2760

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     2820

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     2880

ccac                                                                  2884


<210>  182
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INS-Modified SP of Cpd.31

<400>  182
atggcacttt ggctgctgcc tcttctggct ctgctggctc tttggggacc tgatcctgcc       60

gccgct                                                                  66


<210>  183
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FGF5 SP of Cpd.35

<400>  183
atgagcctga gctttctgct gctgctgttc ttcagccacc tgatcctgtc tgcctgggct       60


<210>  184
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  184

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210>  185
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  185

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Glu Ala 
            20                  25                  30          


Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala 
        35                  40                  45              


Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Gly Ile Val 
    50                  55                  60                  


Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr 
65                  70                  75                  80  


Cys Asn 
        


<210>  186
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  186

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  187
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  187

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210>  188
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  188

Val Lys Met His Thr Met Ser Ser Ser His Leu Phe Tyr Leu Ala Leu 
1               5                   10                  15      


Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala Gly Pro Glu Thr Leu 
            20                  25                  30          


Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly Ser Ser Ser Arg Arg 
    50                  55                  60                  


Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp 
65                  70                  75                  80  


Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu Lys Pro Ala Lys Ser 
                85                  90                  95      


Ala 



<210>  189
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ALPI-Modified SP

<400>  189

Met Leu Leu Val Leu Leu Leu Leu Ala Leu Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Ala Ser Ala Ala Pro 
            20      


<210>  190
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALPI-Modified SP

<400>  190
atgctgcttg ttctgctgct gctggctctg ctgctcctgc ttcttggagc ttctgccgct       60

cct                                                                     63


<210>  191
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of Cpd.39

<400>  191
atgctgcttg ttctgctgct gctggctctg ctgctcctgc ttcttggagc ttctgccgct       60

cctgtgaaga tgcacaccat gagcagcagc cacctgttct atctggccct gtgcctgctg      120

acctttacca gctctgctac cgccggacct gagacacttt gtggcgctga actggtggac      180

gccctgcagt ttgtgtgtgg cgacagaggc ttctacttca acaagcccac aggctacggc      240

agctcctcta gaagggctcc tcagaccgga atcgtggacg agtgctgctt cagaagctgc      300

gacctgcggc ggctggaaat gtattgtgcc cctctgaagc ctgccaagag cgcctaa         357


<210>  192
<211>  357
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA sequence of Cpd.39


<220>
<221>  modified_base
<222>  (1)..(357)
<223>  m1f (uridine is 1-methylpseudouridine)

<400>  192
augcugcuug uucugcugcu gcuggcucug cugcuccugc uucuuggagc uucugccgcu       60

ccugugaaga ugcacaccau gagcagcagc caccuguucu aucuggcccu gugccugcug      120

accuuuacca gcucugcuac cgccggaccu gagacacuuu guggcgcuga acugguggac      180

gcccugcagu uugugugugg cgacagaggc uucuacuuca acaagcccac aggcuacggc      240

agcuccucua gaagggcucc ucagaccgga aucguggacg agugcugcuu cagaagcugc      300

gaccugcggc ggcuggaaau guauugugcc ccucugaagc cugccaagag cgccuaa         357


<210>  193
<211>  2737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of vector_ pMA-T with Cpd.39

<400>  193
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtggccgct acagggcgct cccattcgcc attcaggctg cgcaactgtt      180

gggaagggcg tttcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt      240

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg      300

acggccagtg agcgcgacgt aatacgactc actatagggc gaattggcgg aaggccgtca      360

aggccacgtg tcttgtccag agctcgccac catgctgctt gttctgctgc tgctggctct      420

gctgctcctg cttcttggag cttctgccgc tcctgtgaag atgcacacca tgagcagcag      480

ccacctgttc tatctggccc tgtgcctgct gacctttacc agctctgcta ccgccggacc      540

tgagacactt tgtggcgctg aactggtgga cgccctgcag tttgtgtgtg gcgacagagg      600

cttctacttc aacaagccca caggctacgg cagctcctct agaagggctc ctcagaccgg      660

aatcgtggac gagtgctgct tcagaagctg cgacctgcgg cggctggaaa tgtattgtgc      720

ccctctgaag cctgccaaga gcgcctaagg tacctggagc acaagactgg cctcatgggc      780

cttccgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaacatgg      840

tcatagctgt ttccttgcgt attgggcgct ctccgcttcc tcgctcactg actcgctgcg      900

ctcggtcgtt cgggtaaagc ctggggtgcc taatgagcaa aaggccagca aaaggccagg      960

aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat     1020

cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag     1080

gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga     1140

tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg     1200

tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt     1260

cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac     1320

gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc     1380

ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt     1440

ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc     1500

ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc     1560

agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg     1620

aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag     1680

atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg     1740

tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt     1800

tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca     1860

tctggcccca gtgctgcaat gataccgcga gaaccacgct caccggctcc agatttatca     1920

gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc     1980

tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt     2040

ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg     2100

gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc     2160

aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg     2220

ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga     2280

tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga     2340

ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta     2400

aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg     2460

ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact     2520

ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata     2580

agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt     2640

tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa     2700

ataggggttc cgcgcacatt tccccgaaaa gtgccac                              2737


