               SEQUENCE LISTING

<110> ALDERYS

<120> MALONIC SEMI-ALDEHYDE-PRODUCING YEASTS

<130> PR85460

<150> EP18306717
<151> 2018-12-18

<160> 137

<170> BiSSAP 1.3.6

<210> 1
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence of the enzymes able to catalyze the
      decarboxylation of oxaloacetate into malonic semi-aldehyde

<220> 
<221> VARIANT
<222> 109
<223> Xaa in position 109 is selected from the group consisting of
      leucine, lysine, arginine and valine

<220> 
<221> VARIANT
<222> 110
<223> Xaa in position 110 is selected from the group consisting of
      leucine and lysine

<220> 
<221> VARIANT
<222> 377
<223> Xaa in position 377 is selected from the group consisting of
      threonine and serine

<220> 
<221> VARIANT
<222> 397
<223> Xaa in position 397 is selected from the group consisting of
      phenylalanine, asparagine, alanine, isoleucine and valine

<220> 
<221> VARIANT
<222> 398
<223> Xaa in position 398 is selected from the group consisting of
      cysteine and arginine

<220> 
<221> VARIANT
<222> 403
<223> Xaa in position 403 is selected from the group consisting of
      leucine, asparagine and alanine

<220> 
<221> VARIANT
<222> 460
<223> Xaa in position 460 is selected from the group consisting of
      alanine and leucine

<400> 1
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Xaa Xaa Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Xaa Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Xaa Xaa Ala Ala 
385                 390                 395                 400 
Gly Gly Xaa Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Xaa Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 2
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> enzyme n°1

<400> 2
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 3
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme n°2

<400> 3
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Asn Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 4
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme n°3

<400> 4
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Lys Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Asn Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 5
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme n°4

<400> 5
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Asn Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Leu Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 6
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme n°5

<400> 6
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Val Lys Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Asn Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Asn Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 7
<211> 248
<212> PRT
<213> Escherichia coli K-12


<220> 
<223> YDFG Escherichia Coli BAA15241.1 L-allo-threonine dehydrogenase,
      NAD(P)-binding

<400> 7
Met Ile Val Leu Val Thr Gly Ala Thr Ala Gly Phe Gly Glu Cys Ile 
1               5                   10                  15      
Thr Arg Arg Phe Ile Gln Gln Gly His Lys Val Ile Ala Thr Gly Arg 
            20                  25                  30          
Arg Gln Glu Arg Leu Gln Glu Leu Lys Asp Glu Leu Gly Asp Asn Leu 
        35                  40                  45              
Tyr Ile Ala Gln Leu Asp Val Arg Asn Arg Ala Ala Ile Glu Glu Met 
    50                  55                  60                  
Leu Ala Ser Leu Pro Ala Glu Trp Cys Asn Ile Asp Ile Leu Val Asn 
65                  70                  75                  80  
Asn Ala Gly Leu Ala Leu Gly Met Glu Pro Ala His Lys Ala Ser Val 
                85                  90                  95      
Glu Asp Trp Glu Thr Met Ile Asp Thr Asn Asn Lys Gly Leu Val Tyr 
            100                 105                 110         
Met Thr Arg Ala Val Leu Pro Gly Met Val Glu Arg Asn His Gly His 
        115                 120                 125             
Ile Ile Asn Ile Gly Ser Thr Ala Gly Ser Trp Pro Tyr Ala Gly Gly 
    130                 135                 140                 
Asn Val Tyr Gly Ala Thr Lys Ala Phe Val Arg Gln Phe Ser Leu Asn 
145                 150                 155                 160 
Leu Arg Thr Asp Leu His Gly Thr Ala Val Arg Val Thr Asp Ile Glu 
                165                 170                 175     
Pro Gly Leu Val Gly Gly Thr Glu Phe Ser Asn Val Arg Phe Lys Gly 
            180                 185                 190         
Asp Asp Gly Lys Ala Glu Lys Thr Tyr Gln Asn Thr Val Ala Leu Thr 
        195                 200                 205             
Pro Glu Asp Val Ser Glu Ala Val Trp Trp Val Ser Thr Leu Pro Ala 
    210                 215                 220                 
His Val Asn Ile Asn Thr Leu Glu Met Met Pro Val Thr Gln Ser Tyr 
225                 230                 235                 240 
Ala Gly Leu Asn Val His Arg Gln 
                245             

<210> 8
<211> 1824
<212> PRT
<213> Chloroflexus aggregans


<220> 
<223> Propionyl-CoA synthase Chloroflexus aggregans

<400> 8
Met Ala Ile Asp Thr Ala Pro Pro Ala Pro Ser Arg Ala Pro Arg Ser 
1               5                   10                  15      
Asn Pro Ile Arg Asp Arg Val Asp Trp Glu Thr Gln Arg Ala Ala Ala 
            20                  25                  30          
Leu Ala Asn Pro Gly Ala Phe His Gly Ala Ile Ala Arg Thr Val Ile 
        35                  40                  45              
His Trp Tyr Asp Pro Lys His Asn Cys Trp Ile Arg Phe Asp Glu Ser 
    50                  55                  60                  
Ser Gln Arg Trp Glu Gly Leu Asp Ala Ala Thr Gly Ala Pro Val Thr 
65                  70                  75                  80  
Val Asp Tyr Pro Ala Asp Tyr Gln Pro Trp Gln Gln Ala Phe Asp Asp 
                85                  90                  95      
Ser Glu Ala Pro Phe Tyr Arg Trp Phe Tyr Gly Gly Leu Thr Asn Ala 
            100                 105                 110         
Cys Phe Asn Glu Val Asp Arg His Val Met Met Gly Tyr Gly Asp Glu 
        115                 120                 125             
Val Ala Tyr Tyr Phe Glu Gly Asp Arg Trp Asp Asn Ser Leu Asn Asn 
    130                 135                 140                 
Gly Arg Gly Gly Pro Val Val Gln Glu Thr Ile Thr Arg Arg Arg Leu 
145                 150                 155                 160 
Leu Val Glu Val Val Lys Ala Ala Gln Val Leu Arg Asp Leu Gly Leu 
                165                 170                 175     
Lys Lys Gly Asp Arg Ile Ala Leu Asn Met Pro Asn Ile Met Pro Gln 
            180                 185                 190         
Ile Tyr Tyr Thr Glu Ala Ala Lys Arg Leu Gly Ile Ile Tyr Thr Pro 
        195                 200                 205             
Val Phe Gly Gly Phe Ser Asp Lys Thr Leu Ser Asp Arg Ile His Asn 
    210                 215                 220                 
Ala Gly Ala Arg Val Val Ile Thr Ser Asp Gly Ala Tyr Arg Asn Ala 
225                 230                 235                 240 
Gln Val Val Pro Tyr Lys Glu Ala Tyr Thr Asp Gln Ala Leu Asp Lys 
                245                 250                 255     
Tyr Val Pro Val Glu Thr Val Arg Arg Ile Val Ala Glu Thr Leu Thr 
            260                 265                 270         
Thr Leu Pro Leu Arg Asp Asp Gln Arg Gln Lys Ile Ile Asp Glu Val 
        275                 280                 285             
Glu Ser Val Leu Ser Gly Glu Ile Thr Ile Glu Arg Ser Asp Val Met 
    290                 295                 300                 
Arg Gly Val Gly Ala Ala Leu Ala Gln Ile Arg Asp Leu Asp Ala Ala 
305                 310                 315                 320 
Thr Gln Ala Asn Val Arg Thr Val Leu Ala Gln Ala Leu Val Ala Ser 
                325                 330                 335     
Pro Pro Arg Val Glu Ala Val Ile Val Val Arg His Thr Gly Gln Asp 
            340                 345                 350         
Ile Leu Trp Asn Ala Asp Arg Asp Arg Trp Ser His Glu Leu Leu Glu 
        355                 360                 365             
Ala Ala Leu Ala Lys Ile Leu Ala Asn Ala Arg Ala Ile Gly Ile Asp 
    370                 375                 380                 
Val His Ser Glu Ala Asp Leu Leu Lys Leu Pro Asp Asp Gln Leu Ile 
385                 390                 395                 400 
Arg Ala Leu Tyr Ala Ser Val Pro Cys Glu Pro Val Asp Ala Glu Tyr 
                405                 410                 415     
Pro Met Phe Ile Ile Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys Gly 
            420                 425                 430         
Val Ile His Val His Gly Gly Tyr Val Ser Gly Val Val His Thr Leu 
        435                 440                 445             
Arg Val Ser Phe Asp Ala Glu Pro Gly Asp Thr Ile Tyr Val Ile Ala 
    450                 455                 460                 
Asp Pro Gly Trp Ile Thr Gly Gln Ser Tyr Met Leu Thr Ala Thr Met 
465                 470                 475                 480 
Ala Gly Arg Leu Thr Gly Ile Ile Ala Glu Gly Ser Pro Leu Phe Pro 
                485                 490                 495     
Ser Ser Gly Arg Tyr Ala Ser Ile Ile Glu Arg Tyr Gly Val Gln Ile 
            500                 505                 510         
Phe Lys Ala Gly Val Thr Phe Leu Lys Thr Val Met Ser Asn Pro Gln 
        515                 520                 525             
Asn Ile Glu Asp Val Arg Leu Tyr Asn Met Ser Ser Leu Arg Val Ala 
    530                 535                 540                 
Thr Phe Cys Ala Glu Pro Val Ser Pro Ala Val Gln Gln Phe Gly Met 
545                 550                 555                 560 
Gln Ile Met Thr Pro Gln Tyr Ile Asn Ser Tyr Trp Ala Thr Glu His 
                565                 570                 575     
Gly Gly Ile Val Trp Thr His Phe Tyr Gly Asn Asn Asp Phe Pro Leu 
            580                 585                 590         
Arg Pro Asp Ala His Thr Tyr Pro Leu Pro Trp Val Ala Gly Asp Val 
        595                 600                 605             
Trp Val Ala Glu Thr Asp Glu Ser Gly Asn Val Arg Tyr Arg Val Ala 
    610                 615                 620                 
Asp Tyr Glu Glu Lys Gly Glu Ile Val Ile Thr Ala Pro Tyr Pro Tyr 
625                 630                 635                 640 
Leu Thr Arg Thr Ile Trp Gly Asp Val Pro Gly Phe Glu Ala Tyr Leu 
                645                 650                 655     
Arg Gly Glu Ile Pro Leu Lys Ala Trp Lys Gly Asp Ala Glu Arg Phe 
            660                 665                 670         
Ile Lys Thr Tyr Trp Arg Arg Gly Pro His Gly Glu Trp Gly Tyr Ile 
        675                 680                 685             
Gln Gly Asp Phe Ala Met Lys Tyr Pro Asp Gly Ser Phe Thr Leu His 
    690                 695                 700                 
Gly Arg Ser Asp Asp Val Ile Asn Val Ser Gly His Arg Met Gly Thr 
705                 710                 715                 720 
Glu Glu Ile Glu Gly Ala Ile Leu Arg Asp Arg Gln Ile Thr Pro Asp 
                725                 730                 735     
Ser Pro Val Gly Asn Cys Ile Val Val Gly Ala Pro His Arg Glu Lys 
            740                 745                 750         
Gly Leu Thr Pro Val Ala Phe Ile Gln Pro Ala Pro Gly Arg Arg Leu 
        755                 760                 765             
Thr Ala Ala Asp Arg Arg Arg Leu Asp Glu Leu Val Arg Thr Glu Lys 
    770                 775                 780                 
Gly Ala Val Ser Val Pro Glu Asp Tyr Ile Glu Val Ser Ala Phe Pro 
785                 790                 795                 800 
Glu Thr Arg Ser Gly Lys Tyr Met Arg Arg Phe Leu Arg Asn Met Met 
                805                 810                 815     
Leu Asp Glu Pro Leu Gly Asp Thr Thr Thr Leu Arg Asn Pro Glu Val 
            820                 825                 830         
Leu Glu Glu Ile Ala Ala Lys Ile Ala Glu Trp Lys Arg Lys Gln Arg 
        835                 840                 845             
Leu Ala Glu Glu Gln Gln Ile Ile Glu Arg Tyr Arg Tyr Phe Arg Ile 
    850                 855                 860                 
Glu Tyr His Pro Pro Ala Ala Ser Ala Gly Lys Leu Ala Val Val Thr 
865                 870                 875                 880 
Val Thr Asn Pro Pro Val Asn Ala Leu Asn Glu Arg Ala Leu Asp Glu 
                885                 890                 895     
Leu Asn Thr Ile Val Asp His Leu Ser Arg Arg Asn Asp Val Ala Ala 
            900                 905                 910         
Ile Val Phe Thr Gly Gln Gly Ala Lys Ser Phe Val Ala Gly Ala Asp 
        915                 920                 925             
Ile Arg Gln Leu Leu Glu Glu Ile His Thr Val Glu Glu Ala Met Ala 
    930                 935                 940                 
Leu Pro Asn Asn Ala His Leu Ala Phe Arg Lys Ile Glu Arg Met Asn 
945                 950                 955                 960 
Lys Pro Cys Ile Ala Ala Ile Asn Gly Val Ala Leu Gly Gly Gly Leu 
                965                 970                 975     
Glu Phe Ala Met Ala Cys His Tyr Arg Val Ala Asp Val Tyr Ala Glu 
            980                 985                 990         
Phe Gly Gln Pro Glu Ile Asn Leu Arg Leu Leu Pro Gly Tyr Gly Gly 
        995                 1000                1005            
Thr Gln Arg Leu Pro Arg Leu Leu His Arg Arg Ser Asn Gly Thr Gly 
    1010                1015                1020                
Leu Leu Arg Ala Leu Glu Met Ile Leu Gly Gly Arg Ser Val Pro Ala 
1025                1030                1035                1040
Asp Glu Ala Leu Glu Leu Gly Leu Ile Asp Ala Ile Ala Thr Gly Asp 
                1045                1050                1055    
Ala Asp Ala Leu Met Leu Ala Cys Ser Leu Ala Arg Glu Ala Ile Ala 
            1060                1065                1070        
Ser Asp Gly Thr Leu Arg Glu Asp Ala Ala Val Thr Lys Ala Phe Arg 
        1075                1080                1085            
Gln Arg His Ala Gln Leu Glu Glu Trp Arg Lys Pro Asp Pro His Phe 
    1090                1095                1100                
Thr Asp Asp Gln Leu Arg Ser Ile Ile Ala His Pro Arg Ile Glu Arg 
1105                1110                1115                1120
Ile Ile Lys Gln Ala His Thr Val Gly Arg Asp Val Ala Val His Arg 
                1125                1130                1135    
Ala Leu Asp Ala Ile Arg Tyr Gly Phe Ile His Gly Phe Glu Ala Gly 
            1140                1145                1150        
Leu Glu His Glu Ala Lys Leu Phe Ala Glu Ala Val Val Asp Pro Asn 
        1155                1160                1165            
Gly Gly Lys Arg Gly Ile Arg Glu Phe Leu Asp Arg His Ser Ala Pro 
    1170                1175                1180                
Leu Pro Thr Arg Arg Pro Leu Ile Ser Arg Glu Gln Glu Gln Leu Leu 
1185                1190                1195                1200
Leu Glu Gln Lys Glu Leu Leu Pro Ile Gly Ser Pro Phe Phe Pro Gly 
                1205                1210                1215    
Val Asp Arg Ile Pro Lys Trp Gln Tyr Ala Gln Ala Phe Ile Arg Asp 
            1220                1225                1230        
Pro Glu Thr Gly Ala Ala Met His Gly Asp Pro Ile Val Ala Glu Lys 
        1235                1240                1245            
Gln Ile Ile Ile Pro Val Glu Arg Pro Arg Ala Asn Gln Ala Leu Ile 
    1250                1255                1260                
Tyr Val Leu Ala Ser Glu Val Asn Phe Asn Asp Ile Trp Ala Ile Thr 
1265                1270                1275                1280
Gly Ile Pro Val Ser Arg Phe Asp Glu His Asp Arg Asp Trp His Val 
                1285                1290                1295    
Thr Gly Ser Gly Gly Ile Gly Leu Val Val Ala Leu Gly Glu Glu Ala 
            1300                1305                1310        
Arg Arg Glu Gly Arg Leu Lys Ile Gly Asp Leu Val Ala Ile Tyr Ser 
        1315                1320                1325            
Gly Gln Thr Asp Leu Leu Ser Pro Leu Met Gly Leu Asp Pro Met Ala 
    1330                1335                1340                
Ala Asp Phe Val Ile Gln Gly Asn Asp Thr Pro Asp Gly Ser His Gln 
1345                1350                1355                1360
Gln Phe Met Val Ala Gln Ala Pro Gln Cys Met Pro Val Leu Pro Asp 
                1365                1370                1375    
Met Thr Leu Glu Ala Ala Gly Ser Tyr Ile Leu Asn Leu Gly Thr Ile 
            1380                1385                1390        
Tyr Arg Ala Leu Phe Thr Thr Leu Arg Val Gln Pro Gly Arg Thr Ile 
        1395                1400                1405            
Phe Ile Glu Gly Ala Ala Thr Gly Thr Gly Leu Asp Ala Val Arg Thr 
    1410                1415                1420                
Ala Ala Arg Asn Gly Leu Asn Val Ile Gly Met Val Ser Ser Pro Ser 
1425                1430                1435                1440
Arg Ala Ala Thr Val Leu Ser Ala Gly Gly Lys Gly Ala Ile Asn Arg 
                1445                1450                1455    
Lys Asp Pro Ala Ile Ala Asn Cys Phe Thr Arg Val Pro Glu Asp Pro 
            1460                1465                1470        
Ser Glu Trp Ala Ala Trp Glu Ala Ala Gly His Pro Leu Leu Glu Met 
        1475                1480                1485            
Phe Arg Ala Gln Asn Gly Gly Arg Leu Ala Asp Tyr Val Val Ser His 
    1490                1495                1500                
Ala Gly Glu Thr Ala Phe Pro Arg Ser Phe Gln Leu Leu Gly Glu Pro 
1505                1510                1515                1520
His Asp Gly His Ile Pro Thr Leu Thr Phe Tyr Gly Ala Ser Ser Gly 
                1525                1530                1535    
Tyr His Phe Thr Phe Ile Gly Lys Pro Gly Ala Ala Ser Pro Thr Glu 
            1540                1545                1550        
Met Leu Arg Arg Ala Gly Leu Arg Ala Gly Glu Gly Val Leu Ile Tyr 
        1555                1560                1565            
Tyr Gly Val Gly Ser Pro Glu Leu Ile Asp Gly Ala Gly Leu Glu Ala 
    1570                1575                1580                
Ile Glu Ala Ala Arg Leu Met Gly Ala Arg Ile Val Val Val Thr Ala 
1585                1590                1595                1600
Ser Asp Ala Gln Arg Glu Phe Val Leu Ser Leu Gly Phe Gly Ala Ala 
                1605                1610                1615    
Leu Arg Gly Val Ile Ser Ile Thr Glu Leu Lys Arg Arg Phe Gly Asp 
            1620                1625                1630        
Glu Phe Asp Trp Pro Lys Thr Met Pro Pro Leu Pro Asp Ser Arg Lys 
        1635                1640                1645            
Asp Pro Gln Gly Leu Lys Glu Ala Val Arg Arg Phe Asn Asp Leu Thr 
    1650                1655                1660                
Phe Lys Pro Ile Gly Ser Ala Val Gly Gly Phe Leu Arg Thr Pro Asp 
1665                1670                1675                1680
Asn Pro Arg Gly Tyr Pro Asp Leu Ile Ile Glu Arg Ala Gly His Asp 
                1685                1690                1695    
Ala Leu Ala Val Ser Ala Met Leu Ile Lys Pro Phe Thr Gly Arg Ile 
            1700                1705                1710        
Val Tyr Phe Glu Asp Ile Gly Gly Arg Arg Tyr Ser Phe Phe Ala Pro 
        1715                1720                1725            
Gln Ile Trp Val Arg Gln Arg Arg Ile Tyr Met Pro Thr Ala Gln Ile 
    1730                1735                1740                
Phe Gly Thr His Leu Ser Asn Ala Tyr Glu Ile Val Arg Met Asn Glu 
1745                1750                1755                1760
Glu Ile Ser Ala Gly Leu Ile Thr Ile Thr Glu Pro Ala Val Val Pro 
                1765                1770                1775    
Trp Asp Gln Leu Pro Glu Ala His Gln Ala Met Trp Glu Asn Arg His 
            1780                1785                1790        
Thr Ala Ala Thr Tyr Val Val Asn His Ala Leu Pro Arg Leu Gly Ile 
        1795                1800                1805            
Lys Thr Lys Asp Glu Leu Tyr Glu Ala Trp Thr Ala Ala Asp Arg Glu 
    1810                1815                1820                



<210> 9
<211> 1912
<212> PRT
<213> Roseiflexus castenholzii


<220> 
<223> Propionyl-CoA synthase Roseiflexus castenholzii

<400> 9
Met Thr Thr Ile Glu Ser Ala Leu Arg Pro Pro Arg Ile Asn Pro Val 
1               5                   10                  15      
Arg Thr Arg Ala Asp Trp Glu Ala Gln Arg Lys Ala Ala Leu Thr Asp 
            20                  25                  30          
Pro Gly Ala Phe His Gly Ala Ile Ala Arg Ser Ala Ile His Trp Tyr 
        35                  40                  45              
Asp Arg His Leu Asp Ala Trp Ile Thr Trp Asp Glu Glu Glu Gly Cys 
    50                  55                  60                  
Trp Lys Gly Leu Arg Tyr Ser Asp Gly Ala Pro Ile Asp Val Pro Tyr 
65                  70                  75                  80  
Gly Pro Asp His Glu Pro Trp Glu Arg Ala Phe Asn Gly Asp Asp Pro 
                85                  90                  95      
Pro Phe Tyr Arg Trp Phe Glu Gly Gly Leu Thr Asn Ala Cys Phe Asn 
            100                 105                 110         
Glu Val Asp Arg His Val Leu Thr Gly Tyr Gly Asp Glu Val Ala Phe 
        115                 120                 125             
Tyr Phe Glu Gly Asp Arg Trp Asp Ser Ser Leu Asn Asn Gly Arg Gly 
    130                 135                 140                 
Gly Pro Val Val Ser Phe Ala Val Thr Arg Lys Gln Leu Met Leu Glu 
145                 150                 155                 160 
Val Val Lys Ala Ala Gln Val Leu Arg Asp Leu Gly Leu Asn Met Gly 
                165                 170                 175     
Asp Arg Ile Ala Leu Asn Met Pro Asn Ile Met Glu Gln Leu Tyr Tyr 
            180                 185                 190         
Thr Glu Ala Ala Lys Arg Leu Gly Ile Ile Tyr Thr Pro Val Phe Gly 
        195                 200                 205             
Gly Phe Ser Asp Lys Thr Leu Ser Asp Arg Ile His Asn Ala Gly Ala 
    210                 215                 220                 
Arg Leu Val Ile Thr Ser Asp Gly Ala Tyr Arg Asn Ala Gln Val Val 
225                 230                 235                 240 
Pro Tyr Lys Glu Gln Tyr Thr Asp Gln Ala Leu Asp Lys Phe Val Pro 
                245                 250                 255     
Val Glu Thr Ala Leu Asp Ile Ile Glu Ala Ala Leu Ser Gly Ser Glu 
            260                 265                 270         
Gly Ser Pro Val Pro Gly Ala Pro Leu Leu Ala Pro Asp Gln Ile Lys 
        275                 280                 285             
His Ile Leu Ala Gln Val Arg Asp Ala Leu Lys Glu Asp Ile Thr Ile 
    290                 295                 300                 
Glu Arg Ser Asp Ala Met Arg Ala Val Gly Arg Ala Ile Glu Gly Leu 
305                 310                 315                 320 
Thr Gly Val Asp Ala Leu Ala Gln Ser Arg Ala Arg Thr Ala Val Ala 
                325                 330                 335     
Gln Ala Leu Val Asn Thr Pro Pro Arg Val Asp Ala Val Ile Val Val 
            340                 345                 350         
Arg His Thr Gly Gln Asp Ile Leu Trp Arg Pro Glu Arg Asp Arg Trp 
        355                 360                 365             
Ser His Glu Leu Thr Ala Arg Ala Leu Glu Thr Ile Leu Ala Asn Ala 
    370                 375                 380                 
Arg Ala Val Gly Val Glu Val Tyr Ser Glu Asp Glu Leu Leu Asn Leu 
385                 390                 395                 400 
Pro Thr Asp Gln Phe Val Lys Ala Leu Tyr Ala Thr Ser Arg Ala Glu 
                405                 410                 415     
Pro Leu Asp Ala Glu Tyr Pro Met Phe Ile Ile Tyr Thr Ser Gly Ser 
            420                 425                 430         
Thr Gly Lys Pro Lys Gly Val Val His Val His Gly Gly Tyr Val Ala 
        435                 440                 445             
Gly Val Ala Tyr Thr Met Arg Val Ser Phe Asp Ala Glu Pro Gly Asp 
    450                 455                 460                 
Thr Ile Tyr Val Val Ala Asp Pro Gly Trp Ile Thr Gly Gln Ser Tyr 
465                 470                 475                 480 
Met Ile Cys Ala Thr Leu Thr Thr Arg Cys Thr Gly Ile Ile Thr Glu 
                485                 490                 495     
Gly Ser Pro Val Phe Pro Ser Ala Gly Arg Phe Ala Ser Ile Ile Glu 
            500                 505                 510         
Arg Tyr Lys Val Arg Ile Phe Lys Ala Gly Val Thr Phe Leu Lys Thr 
        515                 520                 525             
Val Met Ser Asp Pro Gln Asn Thr Ala Asp Ala Arg Gln Tyr Asp Met 
    530                 535                 540                 
Ser Ser Leu Arg Val Cys Thr Phe Cys Ala Glu Pro Val Ser Pro Ala 
545                 550                 555                 560 
Val Gln Gln Phe Gly Met Glu Leu Met Ser Pro Gln Tyr Ile Asn Ser 
                565                 570                 575     
Tyr Trp Ala Thr Glu His Gly Gly Ile Val Trp Thr His Phe Tyr Gly 
            580                 585                 590         
Asn Glu Asp Phe Pro Leu Arg Pro Asp Ala His Thr Tyr Pro Leu Pro 
        595                 600                 605             
Trp Ile Ala Gly Glu Val Trp Val Leu Glu Gly Gly Asp Arg Asp Ala 
    610                 615                 620                 
Thr Gly Ala Glu Ala Pro Arg Tyr Arg Ile Ala Asp Tyr Glu Glu Lys 
625                 630                 635                 640 
Gly Glu Ile Val Ile Thr Ala Pro Tyr Pro Tyr Leu Thr Arg Thr Ile 
                645                 650                 655     
Trp Gly Asp Val Lys Gly Phe Glu Ala Trp Val Ala Ala Met Gln His 
            660                 665                 670         
Gly Asn Gly Ala Thr Ala Pro Arg Trp Arg Gly Asp Ala Glu Arg Phe 
        675                 680                 685             
Ile Lys Thr Tyr Trp Arg Arg Gly Pro Asn Asp Glu Trp Gly Tyr Ile 
    690                 695                 700                 
Gln Gly Asp Phe Ala Met Lys Tyr Pro Asp Gly Ser Phe Thr Leu His 
705                 710                 715                 720 
Gly Arg Ser Asp Asp Val Ile Asn Val Ser Gly His Arg Met Gly Thr 
                725                 730                 735     
Glu Glu Ile Glu Gly Ala Ile Leu Arg Asp Lys Ile Ile Thr Pro Asp 
            740                 745                 750         
Ser Pro Val Gly Asn Cys Ile Val Val Gly Ala Pro His Arg Glu Lys 
        755                 760                 765             
Gly Leu Thr Pro Val Ala Phe Ile Leu Thr Ala Pro Gly Arg Lys Leu 
    770                 775                 780                 
Thr Gly Glu Asp Arg Arg Arg Leu Asn Glu Leu Val Arg Asn Glu Lys 
785                 790                 795                 800 
Gly Ala Val Ser Val Pro Glu Asp Tyr Ile Glu Val Ser Ala Phe Pro 
                805                 810                 815     
Glu Thr Arg Ser Gly Lys Tyr Met Arg Arg Phe Leu Arg Asn Leu Met 
            820                 825                 830         
Leu Gly Glu Pro Leu Gly Asp Thr Thr Thr Leu Arg Asn Pro Glu Ser 
        835                 840                 845             
Leu Lys Glu Ile Ala Glu Lys Ile Glu Ala Trp Lys Arg Lys Gln Arg 
    850                 855                 860                 
Met Ala Glu Glu Gln Arg Ile Phe Glu Arg Tyr Arg Tyr Phe Arg Ile 
865                 870                 875                 880 
Glu Tyr His Ala Val Arg Glu Arg Trp Thr Pro Ser Gly Asn Gly Ser 
                885                 890                 895     
Ala Ala Ala Glu Gln Lys Ala Leu Thr Gln Arg Ile Ala Ile Val Thr 
            900                 905                 910         
Val Thr Asn Pro Pro Val Asn Ala Leu Asn Glu Arg Ala Leu Asp Glu 
        915                 920                 925             
Leu Asn Thr Ile Val Asp His Leu Ala Arg Arg Glu Asp Val Ala Ala 
    930                 935                 940                 
Val Val Phe Thr Gly Ser Gly Thr Lys Ser Phe Val Ala Gly Ala Asp 
945                 950                 955                 960 
Ile Lys Gln Met Leu Glu Glu Met His Thr Val Glu Asp Ala Met Ala 
                965                 970                 975     
Leu Pro Asn Asn Ala His Leu Ala Phe Arg Lys Ile Glu Thr Met Asn 
            980                 985                 990         
Lys Pro Cys Ile Ala Ala Ile Asn Gly Val Ala Leu Gly Gly Gly Met 
        995                 1000                1005            
Glu Phe Ala Leu Ala Cys His Tyr Arg Ile Ala Asp Leu His Ala Glu 
    1010                1015                1020                
Phe Gly Gln Pro Glu Ile Asn Leu Arg Leu Leu Pro Gly Tyr Gly Gly 
1025                1030                1035                1040
Thr Gln Arg Leu Pro Arg Leu Leu Tyr Ser Arg Arg Gly Glu Ala Gly 
                1045                1050                1055    
Leu Ile Lys Ala Leu Met Ile Ile Met Gly Gly Arg Thr Leu Asn Ala 
            1060                1065                1070        
Glu Arg Ala Tyr Glu Ile Gly Leu Ile Asp Lys Val Ala His Gly His 
        1075                1080                1085            
Glu Glu Ala Leu Thr Leu Ala Thr Gln Met Ala Arg Glu Met Ile Leu 
    1090                1095                1100                
Ala Glu Arg Asn Gly Lys Pro Thr Glu Leu Arg Val Ile Pro Asn Thr 
1105                1110                1115                1120
Ser Asp Asp Pro Thr Thr Phe Phe Ser Pro Phe His Asp Pro Ala Thr 
                1125                1130                1135    
Ala Gly Glu Gly Leu Trp Pro Pro Leu Pro Glu Ala Tyr Ala Leu Arg 
            1140                1145                1150        
Arg Gln Leu Thr Ala Gln Trp Glu Thr Pro Asp Pro Ala Met Val Asp 
        1155                1160                1165            
Leu Leu Glu Lys Ala Leu Arg Asp Pro Leu Ile Thr Arg Ile Ile Asn 
    1170                1175                1180                
Gln Ala Gln Trp Ala Gly Arg Ala Arg Ala Ile Glu Arg Ile Ile Asp 
1185                1190                1195                1200
Ala Leu Arg Thr Gly Phe Thr Lys Gly Met Leu Ala Gly Leu Glu Arg 
                1205                1210                1215    
Glu Ala Arg Leu Phe Ala Glu Ala Val Val Ala Pro Asp Glu Gly Lys 
            1220                1225                1230        
Ile Gly Ile Gln Asp Phe Leu Asp Lys Arg Ser Ala Pro Leu Pro Thr 
        1235                1240                1245            
Arg Arg Arg Ile His Leu Thr Pro Asp Glu Glu Lys Arg Met Ile Asp 
    1250                1255                1260                
Ala Gly Met Leu Leu Pro Ile Gly Ala Pro Phe Phe Pro Gly Val Thr 
1265                1270                1275                1280
Pro Ile Pro Val Ala Gln Tyr Ala Met Ala Val Val Arg Asp Glu Val 
                1285                1290                1295    
Thr Gly Ala Pro Ala His Gly Asp Pro Ile Glu Ala Glu Lys Gln Ile 
            1300                1305                1310        
Ile Ile Pro Val Glu Lys Pro Gly Pro Asn Asp Val Leu Leu Tyr Ile 
        1315                1320                1325            
Leu Ala Ser Glu Val Asn Phe Asn Asp Ile Trp Ala Ile Thr Gly Val 
    1330                1335                1340                
Pro Val Ser Gln Phe Asp Glu His Asp Arg Asp Trp His Val Thr Gly 
1345                1350                1355                1360
Ser Gly Gly Ile Gly Leu Ile Val Ser Val Gly Glu Glu Thr Lys Arg 
                1365                1370                1375    
Glu Gly Arg Leu Lys Val Gly Asp Leu Val Ala Ile Tyr Ser Gly Gln 
            1380                1385                1390        
Asn Asp Leu Leu Ser Pro Met Val Gly Leu Asp Pro Met Ala Ala Asp 
        1395                1400                1405            
Phe Val Ile Gln Gly Tyr Asn Thr Pro Asp Ala Ser His Gln Gln Phe 
    1410                1415                1420                
Met Val Ala Gln Ala Pro Gln Cys Phe Pro Val Leu Pro Asp Leu Thr 
1425                1430                1435                1440
Leu Glu Ala Ala Gly Ser Tyr Met Leu Asn Leu Gly Thr Val Tyr Arg 
                1445                1450                1455    
Ala Leu Phe Thr Thr Leu Lys Ile Gln Pro Gly Arg Arg Ile Phe Val 
            1460                1465                1470        
Glu Gly Ala Ala Thr Gly Thr Gly Leu Asp Ala Ala Arg Ser Ala Ala 
        1475                1480                1485            
Arg Asn Gly Leu Tyr Val Thr Gly Met Val Ser Ser Gln Glu Arg Ala 
    1490                1495                1500                
Ala Val Val Arg Ala Ala Gly Ala Val Gly Val Ile Asn Arg Arg Asp 
1505                1510                1515                1520
Pro Arg Tyr Ala Gly Ile Phe Thr Arg Val Pro Glu Asp Pro Ala Lys 
                1525                1530                1535    
Trp Ala Glu Trp Glu Ala Ala Gly Arg Pro Leu Leu Glu Asp Tyr Arg 
            1540                1545                1550        
Ala Gln Asn Gly Gly His Leu Ala Asp Tyr Ala Val Ser His Ala Gly 
        1555                1560                1565            
Glu Thr Ala Phe Pro Arg Ser Phe Gln Leu Leu Gly Glu Pro His Asp 
    1570                1575                1580                
Gly His Ile Pro Thr Leu Thr Phe Tyr Gly Ala Ser Ser Gly Tyr His 
1585                1590                1595                1600
Phe Thr Phe Leu Gly Lys Pro Gly Ala Ala Asp Pro Val Glu Met Leu 
                1605                1610                1615    
Arg Arg Ala Gly Leu Arg Ala Gly Glu Ala Val Met Ile Tyr Tyr Gly 
            1620                1625                1630        
Val Asp Asp Arg Ser Tyr Leu Gly Asp Glu Gly Tyr Glu Ser Gly Ala 
        1635                1640                1645            
Val Pro Glu Thr Leu Glu Arg Arg Thr Thr Leu Val Asp Gln Val Gly 
    1650                1655                1660                
Leu Glu Ala Ile Glu Ser Ala Arg Ala Met Gly Ala Arg Ile Val Val 
1665                1670                1675                1680
Val Thr Tyr Thr Asp Ala Gln Arg Glu Phe Val Leu Ser Leu Gly Phe 
                1685                1690                1695    
Gly Ala Ser Leu Lys Gly Val Val Ser Leu Glu Glu Leu His Arg Arg 
            1700                1705                1710        
Tyr Gly Asp Glu Phe Asp Trp Pro Glu Thr Met Pro Pro Leu Pro Asp 
        1715                1720                1725            
Ala Lys Ser Asp Ile His Gly Phe Lys Ala Ala Val Arg Arg Phe Asn 
    1730                1735                1740                
Asp Leu Thr Phe Lys Pro Leu Gly Thr Ala Val Gly Gln Phe Leu Arg 
1745                1750                1755                1760
Ser Asn Asp Asn Pro Arg Gly Tyr Pro Asp Leu Ile Ile Glu Arg Ser 
                1765                1770                1775    
Gly His Asp Thr Leu Ala Val Ser Val Met Leu Ile Lys Pro Phe Thr 
            1780                1785                1790        
Gly Arg Val Val Tyr Phe Glu Asn Met Asp Gly Gln Arg Tyr Ser Phe 
        1795                1800                1805            
Phe Ala Pro Gln Val Trp Met Arg Gln Arg Arg Ile Tyr Met Pro Thr 
    1810                1815                1820                
Ala Asn Ile Trp Gly Thr His Leu Ser Asn Ala Tyr Glu Ile Val Arg 
1825                1830                1835                1840
Leu Asn Asp Glu Ile Ser Ala Gly Leu Leu Ser Ile Thr Glu Pro Thr 
                1845                1850                1855    
Leu Val Glu Trp Asn Asp Leu Pro Gln Ala His Gln Ala Met Trp Glu 
            1860                1865                1870        
Asn Arg His Gln Gly Ala Thr Tyr Val Val Asn His Ala Leu Pro Arg 
        1875                1880                1885            
Pro Gly Leu Lys Asp Lys Asp Glu Leu Tyr Glu Ala Trp Ser Glu Met 
    1890                1895                1900                
Leu Gln Asn Arg Glu Tyr Gly Val 
1905                1910        

<210> 10
<211> 1823
<212> PRT
<213> Chloroflexus aurantiacus


<220> 
<223> Propionyl-CoA synthase Chloroflexus aurantiacus

<400> 10
Met Ala Ile Asp Thr Ala Pro Leu Ala Pro Pro Arg Ala Pro Arg Ser 
1               5                   10                  15      
Asn Pro Ile Arg Asp Arg Val Asp Trp Glu Ala Gln Arg Ala Ala Ala 
            20                  25                  30          
Leu Ala Asp Pro Gly Ala Phe His Gly Ala Ile Ala Arg Thr Val Ile 
        35                  40                  45              
His Trp Tyr Asp Pro Gln His His Cys Trp Ile Arg Phe Asn Glu Ser 
    50                  55                  60                  
Ser Gln Arg Trp Glu Gly Leu Asp Ala Ala Thr Gly Ala Pro Val Thr 
65                  70                  75                  80  
Val Asp Tyr Pro Ala Asp Tyr Gln Pro Trp Gln Gln Ala Phe Asp Asp 
                85                  90                  95      
Ser Glu Ala Pro Phe Tyr Arg Trp Phe Ser Gly Gly Leu Thr Asn Ala 
            100                 105                 110         
Cys Phe Asn Glu Val Asp Arg His Val Thr Met Gly Tyr Gly Asp Glu 
        115                 120                 125             
Val Ala Tyr Tyr Phe Glu Gly Asp Arg Trp Asp Asn Ser Leu Asn Asn 
    130                 135                 140                 
Gly Arg Gly Gly Pro Val Val Gln Glu Thr Ile Thr Arg Arg Arg Leu 
145                 150                 155                 160 
Leu Val Glu Val Val Lys Ala Ala Gln Val Leu Arg Asp Leu Gly Leu 
                165                 170                 175     
Lys Lys Gly Asp Arg Ile Ala Leu Asn Met Pro Asn Ile Met Pro Gln 
            180                 185                 190         
Ile Tyr Tyr Thr Glu Ala Ala Lys Arg Leu Gly Ile Leu Tyr Thr Pro 
        195                 200                 205             
Val Phe Gly Gly Phe Ser Asp Lys Thr Leu Ser Asp Arg Ile His Asn 
    210                 215                 220                 
Ala Gly Ala Arg Val Val Ile Thr Ser Asp Gly Ala Tyr Arg Asn Ala 
225                 230                 235                 240 
Gln Val Val Pro Tyr Lys Glu Ala Tyr Thr Asp Gln Ala Leu Asp Lys 
                245                 250                 255     
Tyr Ile Pro Val Glu Thr Ala Gln Ala Ile Val Ala Gln Thr Leu Ala 
            260                 265                 270         
Thr Leu Pro Leu Thr Glu Ser Gln Arg Gln Thr Ile Ile Thr Glu Val 
        275                 280                 285             
Glu Ala Ala Leu Ala Gly Glu Ile Thr Val Glu Arg Ser Asp Val Met 
    290                 295                 300                 
Arg Gly Val Gly Ser Ala Leu Ala Lys Leu Arg Asp Leu Asp Ala Ser 
305                 310                 315                 320 
Val Gln Ala Lys Val Arg Thr Val Leu Ala Gln Ala Leu Val Glu Ser 
                325                 330                 335     
Pro Pro Arg Val Glu Ala Val Val Val Val Arg His Thr Gly Gln Glu 
            340                 345                 350         
Ile Leu Trp Asn Glu Gly Arg Asp Arg Trp Ser His Asp Leu Leu Asp 
        355                 360                 365             
Ala Ala Leu Ala Lys Ile Leu Ala Asn Ala Arg Ala Ala Gly Phe Asp 
    370                 375                 380                 
Val His Ser Glu Asn Asp Leu Leu Asn Leu Pro Asp Asp Gln Leu Ile 
385                 390                 395                 400 
Arg Ala Leu Tyr Ala Ser Ile Pro Cys Glu Pro Val Asp Ala Glu Tyr 
                405                 410                 415     
Pro Met Phe Ile Ile Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys Gly 
            420                 425                 430         
Val Ile His Val His Gly Gly Tyr Val Ala Gly Val Val His Thr Leu 
        435                 440                 445             
Arg Val Ser Phe Asp Ala Glu Pro Gly Asp Thr Ile Tyr Val Ile Ala 
    450                 455                 460                 
Asp Pro Gly Trp Ile Thr Gly Gln Ser Tyr Met Leu Thr Ala Thr Met 
465                 470                 475                 480 
Ala Gly Arg Leu Thr Gly Val Ile Ala Glu Gly Ser Pro Leu Phe Pro 
                485                 490                 495     
Ser Ala Gly Arg Tyr Ala Ser Ile Ile Glu Arg Tyr Gly Val Gln Ile 
            500                 505                 510         
Phe Lys Ala Gly Val Thr Phe Leu Lys Thr Val Met Ser Asn Pro Gln 
        515                 520                 525             
Asn Val Glu Asp Val Arg Leu Tyr Asp Met His Ser Leu Arg Val Ala 
    530                 535                 540                 
Thr Phe Cys Ala Glu Pro Val Ser Pro Ala Val Gln Gln Phe Gly Met 
545                 550                 555                 560 
Gln Ile Met Thr Pro Gln Tyr Ile Asn Ser Tyr Trp Ala Thr Glu His 
                565                 570                 575     
Gly Gly Ile Val Trp Thr His Phe Tyr Gly Asn Gln Asp Phe Pro Leu 
            580                 585                 590         
Arg Pro Asp Ala His Thr Tyr Pro Leu Pro Trp Val Met Gly Asp Val 
        595                 600                 605             
Trp Val Ala Glu Thr Asp Glu Ser Gly Thr Thr Arg Tyr Arg Val Ala 
    610                 615                 620                 
Asp Phe Asp Glu Lys Gly Glu Ile Val Ile Thr Ala Pro Tyr Pro Tyr 
625                 630                 635                 640 
Leu Thr Arg Thr Leu Trp Gly Asp Val Pro Gly Phe Glu Ala Tyr Leu 
                645                 650                 655     
Arg Gly Glu Ile Pro Leu Arg Ala Trp Lys Gly Asp Ala Glu Arg Phe 
            660                 665                 670         
Val Lys Thr Tyr Trp Arg Arg Gly Pro Asn Gly Glu Trp Gly Tyr Ile 
        675                 680                 685             
Gln Gly Asp Phe Ala Ile Lys Tyr Pro Asp Gly Ser Phe Thr Leu His 
    690                 695                 700                 
Gly Arg Ser Asp Asp Val Ile Asn Val Ser Gly His Arg Met Gly Thr 
705                 710                 715                 720 
Glu Glu Ile Glu Gly Ala Ile Leu Arg Asp Arg Gln Ile Thr Pro Asp 
                725                 730                 735     
Ser Pro Val Gly Asn Cys Ile Val Val Gly Ala Pro His Arg Glu Lys 
            740                 745                 750         
Gly Leu Thr Pro Val Ala Phe Ile Gln Pro Ala Pro Gly Arg His Leu 
        755                 760                 765             
Thr Gly Ala Asp Arg Arg Arg Leu Asp Glu Leu Val Arg Thr Glu Lys 
    770                 775                 780                 
Gly Ala Val Ser Val Pro Glu Asp Tyr Ile Glu Val Ser Ala Phe Pro 
785                 790                 795                 800 
Glu Thr Arg Ser Gly Lys Tyr Met Arg Arg Phe Leu Arg Asn Met Met 
                805                 810                 815     
Leu Asp Glu Pro Leu Gly Asp Thr Thr Thr Leu Arg Asn Pro Glu Val 
            820                 825                 830         
Leu Glu Glu Ile Ala Ala Lys Ile Ala Glu Trp Lys Arg Arg Gln Arg 
        835                 840                 845             
Met Ala Glu Glu Gln Gln Ile Ile Glu Arg Tyr Arg Tyr Phe Arg Ile 
    850                 855                 860                 
Glu Tyr His Pro Pro Thr Ala Ser Ala Gly Lys Leu Ala Val Val Thr 
865                 870                 875                 880 
Val Thr Asn Pro Pro Val Asn Ala Leu Asn Glu Arg Ala Leu Asp Glu 
                885                 890                 895     
Leu Asn Thr Ile Val Asp His Leu Ala Arg Arg Gln Asp Val Ala Ala 
            900                 905                 910         
Ile Val Phe Thr Gly Gln Gly Ala Arg Ser Phe Val Ala Gly Ala Asp 
        915                 920                 925             
Ile Arg Gln Leu Leu Glu Glu Ile His Thr Val Glu Glu Ala Met Ala 
    930                 935                 940                 
Leu Pro Asn Asn Ala His Leu Ala Phe Arg Lys Ile Glu Arg Met Asn 
945                 950                 955                 960 
Lys Pro Cys Ile Ala Ala Ile Asn Gly Val Ala Leu Gly Gly Gly Leu 
                965                 970                 975     
Glu Phe Ala Met Ala Cys His Tyr Arg Val Ala Asp Val Tyr Ala Glu 
            980                 985                 990         
Phe Gly Gln Pro Glu Ile Asn Leu Arg Leu Leu Pro Gly Tyr Gly Gly 
        995                 1000                1005            
Thr Gln Arg Leu Pro Arg Leu Leu Tyr Lys Arg Asn Asn Gly Thr Gly 
    1010                1015                1020                
Leu Leu Arg Ala Leu Glu Met Ile Leu Gly Gly Arg Ser Val Pro Ala 
1025                1030                1035                1040
Asp Glu Ala Leu Glu Leu Gly Leu Ile Asp Ala Ile Ala Thr Gly Asp 
                1045                1050                1055    
Gln Asp Ser Leu Ser Leu Ala Cys Ala Leu Ala Arg Ala Ala Ile Gly 
            1060                1065                1070        
Ala Asp Gly Gln Leu Ile Glu Ser Ala Ala Val Thr Gln Ala Phe Arg 
        1075                1080                1085            
His Arg His Glu Gln Leu Asp Glu Trp Arg Lys Pro Asp Pro Arg Phe 
    1090                1095                1100                
Ala Asp Asp Glu Leu Arg Ser Ile Ile Ala His Pro Arg Ile Glu Arg 
1105                1110                1115                1120
Ile Ile Arg Gln Ala His Thr Val Gly Arg Asp Ala Ala Val His Arg 
                1125                1130                1135    
Ala Leu Asp Ala Ile Arg Tyr Gly Ile Ile His Gly Phe Glu Ala Gly 
            1140                1145                1150        
Leu Glu His Glu Ala Lys Leu Phe Ala Glu Ala Val Val Asp Pro Asn 
        1155                1160                1165            
Gly Gly Lys Arg Gly Ile Arg Glu Phe Leu Asp Arg Gln Ser Ala Pro 
    1170                1175                1180                
Leu Pro Thr Arg Arg Pro Leu Ile Thr Pro Glu Gln Glu Gln Leu Leu 
1185                1190                1195                1200
Arg Asp Gln Lys Glu Leu Leu Pro Val Gly Ser Pro Phe Phe Pro Gly 
                1205                1210                1215    
Val Asp Arg Ile Pro Lys Trp Gln Tyr Ala Gln Ala Val Ile Arg Asp 
            1220                1225                1230        
Pro Asp Thr Gly Ala Ala Ala His Gly Asp Pro Ile Val Ala Glu Lys 
        1235                1240                1245            
Gln Ile Ile Val Pro Val Glu Arg Pro Arg Ala Asn Gln Ala Leu Ile 
    1250                1255                1260                
Tyr Val Leu Ala Ser Glu Val Asn Phe Asn Asp Ile Trp Ala Ile Thr 
1265                1270                1275                1280
Gly Ile Pro Val Ser Arg Phe Asp Glu His Asp Arg Asp Trp His Val 
                1285                1290                1295    
Thr Gly Ser Gly Gly Ile Gly Leu Ile Val Ala Leu Gly Glu Glu Ala 
            1300                1305                1310        
Arg Arg Glu Gly Arg Leu Lys Val Gly Asp Leu Val Ala Ile Tyr Ser 
        1315                1320                1325            
Gly Gln Ser Asp Leu Leu Ser Pro Leu Met Gly Leu Asp Pro Met Ala 
    1330                1335                1340                
Ala Asp Phe Val Ile Gln Gly Asn Asp Thr Pro Asp Gly Ser His Gln 
1345                1350                1355                1360
Gln Phe Met Leu Ala Gln Ala Pro Gln Cys Leu Pro Ile Pro Thr Asp 
                1365                1370                1375    
Met Ser Ile Glu Ala Ala Gly Ser Tyr Ile Leu Asn Leu Gly Thr Ile 
            1380                1385                1390        
Tyr Arg Ala Leu Phe Thr Thr Leu Gln Ile Lys Ala Gly Arg Thr Ile 
        1395                1400                1405            
Phe Ile Glu Gly Ala Ala Thr Gly Thr Gly Leu Asp Ala Ala Arg Ser 
    1410                1415                1420                
Ala Ala Arg Asn Gly Leu Arg Val Ile Gly Met Val Ser Ser Ser Ser 
1425                1430                1435                1440
Arg Ala Ser Thr Leu Leu Ala Ala Gly Ala His Gly Ala Ile Asn Arg 
                1445                1450                1455    
Lys Asp Pro Glu Val Ala Asp Cys Phe Thr Arg Val Pro Glu Asp Pro 
            1460                1465                1470        
Ser Ala Trp Ala Ala Trp Glu Ala Ala Gly Gln Pro Leu Leu Ala Met 
        1475                1480                1485            
Phe Arg Ala Gln Asn Asp Gly Arg Leu Ala Asp Tyr Val Val Ser His 
    1490                1495                1500                
Ala Gly Glu Thr Ala Phe Pro Arg Ser Phe Gln Leu Leu Gly Glu Pro 
1505                1510                1515                1520
Arg Asp Gly His Ile Pro Thr Leu Thr Phe Tyr Gly Ala Thr Ser Gly 
                1525                1530                1535    
Tyr His Phe Thr Phe Leu Gly Lys Pro Gly Ser Ala Ser Pro Thr Glu 
            1540                1545                1550        
Met Leu Arg Arg Ala Asn Leu Arg Ala Gly Glu Ala Val Leu Ile Tyr 
        1555                1560                1565            
Tyr Gly Val Gly Ser Asp Asp Leu Val Asp Thr Gly Gly Leu Glu Ala 
    1570                1575                1580                
Ile Glu Ala Ala Arg Gln Met Gly Ala Arg Ile Val Val Val Thr Val 
1585                1590                1595                1600
Ser Asp Ala Gln Arg Glu Phe Val Leu Ser Leu Gly Phe Gly Ala Ala 
                1605                1610                1615    
Leu Arg Gly Val Val Ser Leu Ala Glu Leu Lys Arg Arg Phe Gly Asp 
            1620                1625                1630        
Glu Phe Glu Trp Pro Arg Thr Met Pro Pro Leu Pro Asn Ala Arg Gln 
        1635                1640                1645            
Asp Pro Gln Gly Leu Lys Glu Ala Val Arg Arg Phe Asn Asp Leu Val 
    1650                1655                1660                
Phe Lys Pro Leu Gly Ser Ala Val Gly Val Phe Leu Arg Ser Ala Asp 
1665                1670                1675                1680
Asn Pro Arg Gly Tyr Pro Asp Leu Ile Ile Glu Arg Ala Ala His Asp 
                1685                1690                1695    
Ala Leu Ala Val Ser Ala Met Leu Ile Lys Pro Phe Thr Gly Arg Ile 
            1700                1705                1710        
Val Tyr Phe Glu Asp Ile Gly Gly Arg Arg Tyr Ser Phe Phe Ala Pro 
        1715                1720                1725            
Gln Ile Trp Val Arg Gln Arg Arg Ile Tyr Met Pro Thr Ala Gln Ile 
    1730                1735                1740                
Phe Gly Thr His Leu Ser Asn Ala Tyr Glu Ile Leu Arg Leu Asn Asp 
1745                1750                1755                1760
Glu Ile Ser Ala Gly Leu Leu Thr Ile Thr Glu Pro Ala Val Val Pro 
                1765                1770                1775    
Trp Asp Glu Leu Pro Glu Ala His Gln Ala Met Trp Glu Asn Arg His 
            1780                1785                1790        
Thr Ala Ala Thr Tyr Val Val Asn His Ala Leu Pro Arg Leu Gly Leu 
        1795                1800                1805            
Lys Asn Arg Asp Glu Leu Tyr Glu Ala Trp Thr Ala Gly Glu Arg 
    1810                1815                1820            

<210> 11
<211> 865
<212> PRT
<213> Clostridium beijerinckii


<220> 
<223> ADHE2 Clostridium beijerinckii

<400> 11
Met Ala Arg Val Thr Asn Pro Glu Glu Leu Thr Lys Arg Ile Glu Gln 
1               5                   10                  15      
Ile Arg Glu Ala Gln Arg Glu Phe Ala Lys Phe Ser Gln Glu Glu Val 
            20                  25                  30          
Asp Glu Ile Phe Arg Gln Ala Ala Met Ala Ala Asn Asn Ala Arg Ile 
        35                  40                  45              
Thr Leu Ala Lys Met Ala Val Glu Glu Ser Gly Met Gly Ile Val Glu 
    50                  55                  60                  
Asp Lys Val Ile Lys Asn His Phe Ala Ala Glu Tyr Ile Tyr Asn Gln 
65                  70                  75                  80  
Tyr Lys Asp Thr Lys Thr Cys Gly Val Ile Glu Arg Asp Glu Met Phe 
                85                  90                  95      
Gly Ile Thr His Ile Ala Glu Pro Ile Gly Val Ile Ala Ala Ile Val 
            100                 105                 110         
Pro Thr Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Thr Leu Ile Ala 
        115                 120                 125             
Leu Lys Thr Arg Asn Gly Ile Ile Ile Ser Pro His Pro Arg Ala Lys 
    130                 135                 140                 
Asn Ser Thr Ile Ala Ala Ala Lys Ile Val Leu Glu Ala Ala Glu Arg 
145                 150                 155                 160 
Ala Gly Ala Pro Lys Gly Ile Ile Gly Trp Ile Asp Glu Pro Ser Ile 
                165                 170                 175     
Glu Leu Ser Arg Asn Val Met Ala Glu Ser Asp Ile Ile Leu Ala Thr 
            180                 185                 190         
Gly Gly Pro Gly Met Val Arg Ala Ala Tyr Ser Ser Gly Lys Pro Ala 
        195                 200                 205             
Ile Gly Val Gly Ala Gly Asn Thr Pro Ala Ile Ile Asp Asp Thr Ala 
    210                 215                 220                 
His Ile Lys Met Ala Val Asn Ser Ile Leu Leu Ser Lys Thr Phe Asp 
225                 230                 235                 240 
Asn Gly Val Val Cys Ala Ser Glu Gln Ser Ile Ile Ala Met Glu Ser 
                245                 250                 255     
Val Tyr Asp Glu Val Leu Lys Glu Leu Asp Glu Arg Gly Ala Tyr Ile 
            260                 265                 270         
Leu Lys Gly Asp Glu Val Asp Lys Val Arg Ser Ile Ile Leu Asp Ser 
        275                 280                 285             
Lys Gly Ser Leu Asn Ser Glu Ile Val Gly Gln Ser Ala Tyr Lys Ile 
    290                 295                 300                 
Ala Lys Met Ala Gly Val Glu Ile Ser Glu Ala Val Lys Val Leu Ile 
305                 310                 315                 320 
Gly Glu Val Glu Ser Pro Glu Leu Glu Glu Pro Phe Ser His Glu Lys 
                325                 330                 335     
Leu Ser Pro Ile Leu Gly Met Tyr Lys Ala Lys Thr Phe Asp Asp Ala 
            340                 345                 350         
Leu Arg Leu Ala Ser Arg Met Ile Glu Leu Gly Gly Phe Gly His Thr 
        355                 360                 365             
Ser Ile Leu Tyr Thr Asn Gln Val Glu Ser Val Asp Arg Ile Glu Lys 
    370                 375                 380                 
Phe Gly Val Ala Met Lys Thr Ala Arg Thr Leu Ile Asn Met Pro Ala 
385                 390                 395                 400 
Ser Gln Gly Ala Ile Gly Asp Ile Tyr Asn Phe Lys Leu Ala Pro Ser 
                405                 410                 415     
Leu Thr Leu Gly Cys Gly Ser Trp Gly Gly Asn Ser Ile Ser Glu Asn 
            420                 425                 430         
Val Gly Pro Lys His Leu Ile Asn Val Lys Arg Ile Ala Glu Arg Arg 
        435                 440                 445             
Glu Asn Met Leu Trp Phe Arg Val Pro Asp Lys Ile Tyr Phe Lys Phe 
    450                 455                 460                 
Gly Cys Leu Pro Val Ala Leu Glu Glu Leu Asn Ala Met Lys Lys Lys 
465                 470                 475                 480 
Arg Ala Phe Ile Val Thr Asp Arg Val Leu Phe Asp Leu Gly Tyr Thr 
                485                 490                 495     
His Lys Ile Thr Asn Ile Leu Ser Glu Asn His Ile Glu Tyr Lys Ile 
            500                 505                 510         
Phe Ser Asp Val Glu Pro Asp Pro Thr Leu Lys Ala Ala Lys Leu Gly 
        515                 520                 525             
Ala Asp Ala Met Arg Asp Phe Asn Pro Asp Val Ile Ile Ala Ile Gly 
    530                 535                 540                 
Gly Gly Ser Pro Met Asp Ala Ala Lys Ile Met Trp Val Met Tyr Glu 
545                 550                 555                 560 
His Pro Asp Val Arg Phe Glu Asp Leu Ala Met Arg Phe Met Asp Ile 
                565                 570                 575     
Arg Lys Arg Val Tyr Glu Phe Pro Pro Met Gly Glu Lys Ala Ile Leu 
            580                 585                 590         
Val Ala Ile Pro Thr Ser Ala Gly Thr Gly Ser Glu Val Thr Pro Phe 
        595                 600                 605             
Ala Val Ile Thr Asp Gln Gln Thr Gly Val Lys Tyr Pro Leu Ala Asp 
    610                 615                 620                 
Tyr Ala Leu Thr Pro Asn Met Ala Ile Ile Asp Ala Glu Leu Met Met 
625                 630                 635                 640 
Ser Met Pro Lys Gly Leu Thr Ala Ala Ser Gly Ile Asp Ala Leu Val 
                645                 650                 655     
His Ala Ile Glu Ala Tyr Val Ser Val Leu Ala Ser Glu Tyr Thr Asn 
            660                 665                 670         
Gly Leu Ala Leu Glu Ala Ile Arg Leu Thr Phe Lys Tyr Leu Pro Asp 
        675                 680                 685             
Ala Tyr Asn Gly Gly Thr Thr Asn Ile Lys Ala Arg Glu Lys Met Ala 
    690                 695                 700                 
His Ala Ser Ser Val Ala Gly Met Ala Phe Ala Asn Ala Phe Leu Gly 
705                 710                 715                 720 
Ile Cys His Ser Met Ala His Lys Leu Gly Ala Phe His His Val Pro 
                725                 730                 735     
His Gly Ile Ala Asn Ala Leu Leu Ile Asp Glu Val Ile Arg Phe Asn 
            740                 745                 750         
Ala Thr Asp Ala Pro Arg Lys Gln Ala Ala Phe Pro Gln Tyr Lys Tyr 
        755                 760                 765             
Pro Asn Ala Gly Trp Arg Tyr Ala Arg Ile Ala Asp Tyr Leu Asn Leu 
    770                 775                 780                 
Gly Gly Asn Thr Glu Glu Glu Lys Val Glu Leu Leu Ile Lys Ala Ile 
785                 790                 795                 800 
Asp Asp Leu Lys Gly Lys Val Gly Ile Pro Lys Ser Ile Lys Glu Phe 
                805                 810                 815     
Gly Val Ser Glu Glu Lys Phe Tyr Ala Ser Met Asp Glu Met Val Glu 
            820                 825                 830         
Gln Ala Phe Asp Asp Gln Cys Thr Gly Ala Asn Pro Arg Tyr Pro Leu 
        835                 840                 845             
Met Ser Glu Ile Lys Glu Met Tyr Ile Lys Ser Tyr Asn Val Ser Asn 
    850                 855                 860                 
Lys 
865 

<210> 12
<211> 869
<212> PRT
<213> Clostridium arbusti


<220> 
<223> ADHE from Clostridium arbusti

<400> 12
Met Ala Lys Val Ser Asn Ile Asp Glu Leu Asn Val Arg Leu Glu Glu 
1               5                   10                  15      
Ile Arg Glu Ala Gln Arg Lys Phe Gly Thr Tyr Thr Gln Glu Gln Val 
            20                  25                  30          
Asp Glu Ile Phe Arg Gln Ala Ala Met Ala Ala Leu Asp Ala Arg Ile 
        35                  40                  45              
Pro Leu Ala Lys Met Ala Ala Glu Glu Thr Gly Met Gly Leu Val Glu 
    50                  55                  60                  
Asp Lys Val Ile Lys Asn His Phe Ala Ala Glu Tyr Ile Tyr Asn Gln 
65                  70                  75                  80  
Tyr Lys Asp Glu Lys Thr Cys Gly Val Val Glu Thr Asp Lys Ser Tyr 
                85                  90                  95      
Gly Ile Thr Lys Ile Ala Glu Pro Ile Gly Ile Val Ala Ala Val Ile 
            100                 105                 110         
Pro Thr Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Thr Leu Ile Ser 
        115                 120                 125             
Leu Lys Thr Arg Asn Ala Ile Met Leu Ser Pro His Pro Arg Ala Lys 
    130                 135                 140                 
Lys Ser Thr Ile Ala Ala Ala Lys Ile Ile Leu Asp Ala Ala Val Lys 
145                 150                 155                 160 
Ala Gly Ala Pro Glu Gly Ile Ile Gly Trp Ile Asp Glu Pro Ser Ile 
                165                 170                 175     
Glu Leu Thr Gln Ile Leu Met Gln Glu Ala Asp Ile Thr Leu Ala Thr 
            180                 185                 190         
Gly Gly Pro Ser Met Val Lys Ser Ala Tyr Ser Ser Gly Lys Pro Ala 
        195                 200                 205             
Ile Gly Val Gly Pro Gly Asn Thr Pro Val Ile Ile Asp Glu Ser Ala 
    210                 215                 220                 
His Ile Lys Met Ala Val Ser Ser Val Ile Leu Ser Lys Thr Phe Asp 
225                 230                 235                 240 
Asn Gly Val Ile Cys Ala Ser Glu Gln Ser Val Ile Val Leu Asp Ser 
                245                 250                 255     
Ile Tyr Asp Glu Val Arg Lys Glu Phe Ala Glu Arg Gly Ala Tyr Ile 
            260                 265                 270         
Ile Lys Glu Ser Glu Ile Asp Lys Val Arg Lys Thr Ile Phe Ile Asn 
        275                 280                 285             
Gly Ser Ile Asn Ser Lys Ile Val Gly Gln Ser Ala Tyr Lys Ile Ala 
    290                 295                 300                 
Glu Met Ser Gly Ile Lys Val Pro Glu Thr Ala Arg Ile Leu Ile Gly 
305                 310                 315                 320 
Glu Val Thr Ser Val Gly Lys Glu Glu Pro Phe Ala His Glu Lys Leu 
                325                 330                 335     
Ser Thr Val Leu Ala Met Tyr Arg Ala Glu Asn Phe Asp Asp Ala Leu 
            340                 345                 350         
Asp Lys Ala Val Thr Leu Val Asn Leu Gly Gly Leu Gly His Thr Ser 
        355                 360                 365             
Ala Ile Tyr Ala Asp Ile Ile Lys Ala Lys Asp Lys Ile Asp Lys Phe 
    370                 375                 380                 
Ser Asn Ala Met Lys Thr Val Arg Thr Phe Ile Asn Ile Pro Ala Ala 
385                 390                 395                 400 
Gln Gly Ala Ser Gly Asp Leu Tyr Asn Phe Lys Ile Ala Pro Ser Phe 
                405                 410                 415     
Thr Leu Gly Cys Gly Ser Trp Gly Gly Asn Ser Val Ser Glu Asn Val 
            420                 425                 430         
Gly Pro Lys His Leu Leu Asn Ile Lys Arg Val Ala Glu Arg Arg Glu 
        435                 440                 445             
Asn Met Leu Trp Phe Arg Val Pro Glu Lys Val Tyr Phe Lys Phe Gly 
    450                 455                 460                 
Cys Leu Gln Phe Ala Leu Arg Glu Leu Lys Asp Leu Asn Lys Lys Arg 
465                 470                 475                 480 
Ala Phe Ile Val Thr Asp Lys Val Leu Tyr Asp Leu Gly Tyr Ala Asp 
                485                 490                 495     
Ala Ile Thr Lys Val Leu Glu Glu Ile Gly Val Asp Phe Lys Val Phe 
            500                 505                 510         
Thr Glu Val Glu Pro Asp Pro Thr Leu Ser Thr Ala Arg Lys Gly Thr 
        515                 520                 525             
Glu Glu Met Met Asp Phe Lys Pro Asp Thr Ile Ile Ser Leu Gly Gly 
    530                 535                 540                 
Gly Ser Ala Met Asp Ala Ala Lys Ile Met Trp Val Met Tyr Glu His 
545                 550                 555                 560 
Pro Glu Val Lys Phe Glu Asp Leu Ala Met Arg Phe Met Asp Ile Arg 
                565                 570                 575     
Lys Arg Ile Tyr Asn Phe Pro Lys Leu Gly Glu Lys Ala Met Met Ile 
            580                 585                 590         
Ala Val Ala Thr Ser Ala Gly Thr Gly Ser Glu Val Thr Pro Phe Ala 
        595                 600                 605             
Val Ile Thr Asp Glu Lys Thr Gly Val Lys Tyr Pro Leu Ala Asp Tyr 
    610                 615                 620                 
Glu Leu Thr Pro Asn Met Ala Ile Val Asp Ala Glu Leu Met Met Asn 
625                 630                 635                 640 
Met Pro Lys Gly Leu Thr Ala Ala Ser Gly Ile Asp Ala Leu Ile His 
                645                 650                 655     
Gly Ile Glu Ala Tyr Thr Ser Val Leu Ala Ser Glu Tyr Thr Asn Gly 
            660                 665                 670         
Leu Ala Leu Glu Ala Ile Arg Leu Ile Phe Lys Tyr Leu Pro Thr Ala 
        675                 680                 685             
Tyr Ala Glu Gly Thr Thr Asn Glu Lys Ala Arg Glu Lys Met Ala His 
    690                 695                 700                 
Ala Ser Thr Met Ala Gly Met Ala Phe Ala Asn Ala Phe Leu Gly Val 
705                 710                 715                 720 
Cys His Ser Met Ala His Lys Leu Gly Ala Glu His His Ile Ala His 
                725                 730                 735     
Gly Thr Ala Asn Ala Leu Leu Ile Glu Glu Val Ile Arg Phe Asn Ser 
            740                 745                 750         
Ala Asp Asn Pro Val Lys Gln Ala Ala Tyr Pro Gln Tyr Lys Tyr Pro 
        755                 760                 765             
Asn Ala Lys Trp Arg Tyr Gly Lys Ile Ala Asp Tyr Leu Asn Leu Gly 
    770                 775                 780                 
Gly Asn Thr Asp Asp Glu Lys Val Glu Leu Leu Ile Lys Ala Ile His 
785                 790                 795                 800 
Glu Leu Lys Glu Lys Ile Asn Ile Pro Met Ser Ile Lys Asp Ala Gly 
                805                 810                 815     
Val Ser Glu Lys Asn Phe Tyr Ala Thr Leu Asp Lys Met Cys Glu Leu 
            820                 825                 830         
Ala Phe Asp Asp Gln Cys Thr Gly Ala Asn Pro Arg Tyr Pro Leu Ile 
        835                 840                 845             
Ser Glu Ile Lys Gln Met Leu Ile Thr Ala Phe Asp Lys Thr Glu Ile 
    850                 855                 860                 
Asn Thr Glu Ile Lys 
865                 

<210> 13
<211> 554
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pTDH3

<220> 
<223> pTDH3

<400> 13
ccaaaatagg gggcgggtta cacagaatat ataacatcgt aggtgtctgg gtgaacagtt      60

tattcctggc atccactaaa tataatggag cccgcttttt aagctggcat ccagaaaaaa     120

aaagaatccc agcaccaaaa tattgttttc ttcaccaacc atcagttcat aggtccattc     180

tcttagcgca actacagaga acaggggcac aaacaggcaa aaaacgggca caacctcaat     240

ggagtgatgc aacctgcctg gagtaaatga tgacacaagg caattgaccc acgcatgtat     300

ctatctcatt ttcttacacc ttctattacc ttctgctctc tctgatttgg aaaaagctga     360

aaaaaaaggt tgaaaccagt tccctgaaat tattccccta cttgactaat aagtatataa     420

agacggtagg tattgattgt aattctgtaa atctatttct taaacttctt aaattctact     480

tttatagtta gtcttttttt tagttttaaa acaccaagaa cttagtttcg aataaacaca     540

cataaacaaa caaa                                                       554


<210> 14
<211> 550
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pENO2

<220> 
<223> pENO2

<400> 14
cgctcagcat ctgcttcttc ccaaagatga acgcggcgtt atgtcactaa cgacgtgcac      60

caacttgcgg aaagtggaat cccgttccaa aactggcatc cactaattga tacatctaca     120

caccgcacgc cttttttctg aagcccactt tcgtggactt tgccatatgc aaaattcatg     180

aagtgtgata ccaagtcagc atacacctca ctagggtagt ttctttggtt gtattgatca     240

tttggttcat cgtggttcat taattttttt tctccattgc tttctggctt tgatcttact     300

atcatttgga tttttgtcga aggttgtaga attgtatgtg acaagtggca ccaagcatat     360

ataaaaaaaa aaagcattat cttcctacca gagttgattg ttaaaaacgt atttatagca     420

aacgcaattg taattaattc ttattttgta tcttttcttc ccttgtctca atcttttatt     480

tttattttat ttttcttttc ttagtttctt tcataacacc aagcaactaa tactataaca     540

tacaataata                                                            550


<210> 15
<211> 419
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pTEF Kl

<220> 
<223> pTEF Kl

<400> 15
ctctctcgca ataacaatga acactgggtc aatcatagcc tacacaggtg aacagagtag      60

cgtttataca gggtttatac ggtgattcct acggcaaaaa tttttcattt ctaaaaaaaa     120

aaagaaaaat ttttctttcc aacgctagaa ggaaaagaaa aatctaatta aattgatttg     180

gtgattttct gagagttccc tttttcatat atcgaatttt gaatataaaa ggagatcgaa     240

aaaatttttc tattcaatct gttttctggt tttatttgat agtttttttg tgtattatta     300

ttatggatta gtactggttt atatgggttt ttctgtataa cttcttttta ttttagtttg     360

tttaatctta ttttgagtta cattatagtt ccctaactgc aagagaagta acattaaaa      419


<210> 16
<211> 598
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pTEF3

<220> 
<223> pTEF3

<400> 16
ggctgataat agcgtataaa caatgcatac tttgtacgtt caaaatacaa tgcagtagat      60

atatttatgc atattacata taatacatat cacataggaa gcaacaggcg cgttggactt     120

ttaattttcg aggaccgcga atccttacat cacacccaat cccccacaag tgatccccca     180

cacaccatag cttcaaaatg tttctactcc ttttttactc ttccagattt tctcggactc     240

cgcgcatcgc cgtaccactt caaaacaccc aagcacagca tactaaattt cccctctttc     300

ttcctctagg gtgtcgttaa ttacccgtac taaaggtttg gaaaagaaaa aagagaccgc     360

ctcgtttctt tttcttcgtc gaaaaaggca ataaaaattt ttatcacgtt tctttttctt     420

gaaaattttt ttttttgatt tttttctctt tcgatgacct cccattgata tttaagttaa     480

taaacggtct tcaatttctc aagtttcagt ttcatttttc ttgttctatt acaacttttt     540

ttacttcttg ctcattagaa agaaagcata gcaatctaat ctaagtttta attacaaa       598


<210> 17
<211> 383
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pTEF1

<220> 
<223> pTEF1

<400> 17
gtttagcttg cctcgtcccc gccgggtcac ccggccagcg acatggaggc ccagaatacc      60

ctccttgaca gtcttgacgt gcgcagctca ggggcatgat gtgactgtcg cccgtacatt     120

tagcccatac atccccatgt ataatcattt gcatccatac attttgatgg ccgcacggcg     180

cgaagcaaaa attacggctc ctcgctgcag acctgcgagc agggaaacgc tcccctcaca     240

gacgcgttga attgtcccca cgccgcgccc ctgtagagaa atataaaagg ttaggatttg     300

ccactgaggt tcttctttca tatacttcct tttaaaatct tgctacgata cagttctcac     360

atcacatccg aacataaaca acc                                             383


<210> 18
<211> 700
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pADH1

<220> 
<223> pADH1

<400> 18
gggtgtacaa tatggacttc ctcttttctg gcaaccaaac ccatacatcg ggattcctat      60

aataccttcg ttggtctccc taacatgtag gtggcggagg ggagatatac aatagaacag     120

ataccagaca agacataatg ggctaaacaa gactacacca attacactgc ctcattgatg     180

gtggtacata acgaactaat actgtagccc tagacttgat agccatcatc atatcgaagt     240

ttcactaccc tttttccatt tgccatctat tgaagtaata ataggcgcat gcaacttctt     300

ttcttttttt ttcttttctc tctcccccgt tgttgtctca ccatatccgc aatgacaaaa     360

aaatgatgga agacactaaa ggaaaaaatt aacgacaaag acagcaccaa cagatgtcgt     420

tgttccagag ctgatgaggg gtatctcgaa gcacacgaaa ctttttcctt ccttcattca     480

cgcacactac tctctaatga gcaacggtat acggccttcc ttccagttac ttgaatttga     540

aataaaaaaa agtttgctgt cttgctatca agtataaata gacctgcaat tattaatctt     600

ttgtttcctc gtcattgttc tcgttccctt tcttccttgt ttctttttct gcacaatatt     660

tcaagctata ccaagcatac aatcaactat ctcatataca                           700


<210> 19
<211> 549
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pGMP 1

<220> 
<223> pGMP 1

<400> 19
gccaaacttt tcggttaaca catgcagtga tgcacgcgcg atggtgctaa gttacatata      60

tatatatata tatatatata tatatatata gccatagtga tgtctaagta acctttatgg     120

tatatttctt aatgtggaaa gatactagcg cgcgcaccca cacacaagct tcgtcttttc     180

ttgaagaaaa gaggaagctc gctaaatggg attccacttt ccgttccctg ccagctgatg     240

gaaaaaggtt agtggaacga tgaagaataa aaagagagat ccactgaggt gaaatttcag     300

ctgacagcga gtttcatgat cgtgatgaac aatggtaacg agttgtggct gttgccaggg     360

agggtggttc tcaactttta atgtatggcc aaatcgctac ttgggtttgt tatataacaa     420

agaagaaata atgaactgat tctcttcctc cttcttgtcc tttcttaatt ctgttgtaat     480

taccttcctt tgtaattttt tttgtaatta ttcttcttaa taatccaaac aaacacacat     540

attacaata                                                             549


<210> 20
<211> 650
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pFBA1

<220> 
<223> pFBA1

<400> 20
acgcaagccc taagaaatga ataacaatac tgacagtact aaataattgc ctacttggct      60

tcacatacgt tgcatacgtc gatatagata ataatgataa tgacagcagg attatcgtaa     120

tacgtaatag ttgaaaatct caaaaatgtg tgggtcatta cgtaaataat gataggaatg     180

ggattcttct atttttcctt tttccattct agcagccgtc gggaaaacgt ggcatcctct     240

ctttcgggct caattggagt cacgctgccg tgagcatcct ctctttccat atctaacaac     300

tgagcacgta accaatggaa aagcatgagc ttagcgttgc tccaaaaaag tattggatgg     360

ttaataccat ttgtctgttc tcttctgact ttgactcctc aaaaaaaaaa aatctacaat     420

caacagatcg cttcaattac gccctcacaa aaactttttt ccttcttctt cgcccacgtt     480

aaattttatc cctcatgttg tctaacggat ttctgcactt gatttattat aaaaagacaa     540

agacataata cttctctatc aatttcagtt attgttcttc cttgcgttat tcttctgttc     600

ttctttttct tttgtcatat ataaccataa ccaagtaata catattcaaa                650


<210> 21
<211> 700
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pPDC1

<220> 
<223> pPDC1

<400> 21
ttatttacct atctctaaac ttcaacacct tatatcataa ctaatatttc ttgagataag      60

cacactgcac ccataccttc cttaaaaacg tagcttccag tttttggtgg ttccggcttc     120

cttcccgatt ccgcccgcta aacgcatatt tttgttgcct ggtggcattt gcaaaatgca     180

taacctatgc atttaaaaga ttatgtatgc tcttctgact tttcgtgtga tgaggctcgt     240

ggaaaaaatg aataatttat gaatttgaga acaattttgt gttgttacgg tattttacta     300

tggaataatc aatcaattga ggattttatg caaatatcgt ttgaatattt ttccgaccct     360

ttgagtactt ttcttcataa ttgcataata ttgtccgctg cccctttttc tgttagacgg     420

tgtcttgatc tacttgctat cgttcaacac caccttattt tctaactatt ttttttttag     480

ctcatttgaa tcagcttatg gtgatggcac atttttgcat aaacctagct gtcctcgttg     540

aacataggaa aaaaaaatat ataaacaagg ctctttcact ctccttgcaa tcagatttgg     600

gtttgttccc tttattttca tatttcttgt catattcctt tctcaattat tattttctac     660

tcataacctc acgcaaaata acacagtcaa atcaatcaaa                           700


<210> 22
<211> 998
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pCCW12

<220> 
<223> pCCW12

<400> 22
aaccagggca aagcaaaata aaagaaactt aatacgttat gccgtaatga agggctacca      60

aaaacgataa tctcaactgt aaacaggtac aatgcggacc cttttgccac aaaacataca     120

tcattcattg ccggaaaaag aaagaagtga agacagcagt gcagccagcc atgttgcgcc     180

aatctaatta tagatgctgg tgccctgagg atgtatctgg agccagccat ggcatcatgc     240

gctaccgccg gatgtaaaat ccgacacgca aaagaaaacc ttcgaggttg cgcacttcgc     300

ccacccatga accacacggt tagtccaaaa ggggcagttc agattccaga tgcgggaatt     360

agcttgctgc caccctcacc tcactaacgc tgcggtgtgc ggatacttca tgctatttat     420

agacgcgcgt gtcggaatca gcacgcgcaa gaaccaaatg ggaaaatcgg aatgggtcca     480

gaactgcttt gagtgctggc tattggcgtc tgatttccgt tttgggaatc ctttgccgcg     540

cgcccctctc aaaactccgc acaagtccca gaaagcggga aagaaataaa acgccaccaa     600

aaaaaaaaat aaaagccaat cctcgaagcg tgggtggtag gccctggatt atcccgtaca     660

agtatttctc aggagtaaaa aaaccgtttg ttttggaatt ccccatttcg cggccaccta     720

cgccgctatc tttgcaacaa ctatctgcga taactcagca aattttgcat attcgtgttg     780

cagtattgcg ataatgggag tcttacttcc aacataacgg cagaaagaaa tgtgagaaaa     840

ttttgcatcc tttgcctccg ttcaagtata taaagtcggc atgcttgata atctttcttt     900

ccatcctaca ttgttctaat tattcttatt ctcctttatt ctttcctaac ataccaagaa     960

attaatcttc tgtcattcgc ttaaacacta tatcaata                             998


<210> 23
<211> 700
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pGK1

<220> 
<223> pGK1

<400> 23
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaaaaaac ccagacacgc     240

tcgacttcct gtcttcctat tgattgcagc ttccaatttc gtcacacaac aaggtcctag     300

cgacggctca caggttttgt aacaagcaat cgaaggttct ggaatggcgg gaaagggttt     360

agtaccacat gctatgatgc ccactgtgat ctccagagca aagttcgttc gatcgtactg     420

ttactctctc tctttcaaac agaattgtcc gaatcgtgtg acaacaacag cctgttctca     480

cacactcttt tcttctaacc aagggggtgg tttagtttag tagaacctcg tgaaacttac     540

atttacatat atataaactt gcataaattg gtcaatgcaa gaaatacata tttggtcttt     600

tctaattcgt agtttttcaa gttcttagat gctttctttt tctctttttt acagatcatc     660

aaggaagtaa ttatctactt tttacaacaa atataaaaca                           700


<210> 24
<211> 400
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pSAM4

<220> 
<223> pSAM4

<400> 24
agattttggt gttagatggt actcttgcat atgtaacctt taataaattt tgcaaatcga      60

attcctttgt aacgtgcaaa gcattttata gcctggcgct cgcattgtta agcaacaggc     120

ggtgcggcaa cgttgaaatg tttcacgcag ggttttttac gtactgcacg gcattctgga     180

gtgaaaaaaa atgaaaagta cagctcgaag ttttttgtcc atcggttgta ctttgcagag     240

tattagtcat ttttgatatc agagtactac tatcgaagca tttttacgct tgaataactt     300

gaatattatt gaaagcttag ttcaaccaag ctgaaaagaa ccattattca acataattgg     360

aaatcatttc gttactaaat cgtccgaaaa ttgcagaaaa                           400


<210> 25
<211> 505
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pCUP1-1

<220> 
<223> pCUP1-1

<400> 25
cggcaaactt caacgatttc tatgatgcat tttataatta gtaagccgat cccattaccg      60

acatttgggc gctatacgtg catatgttca tgtatgtatc tgtatttaaa acacttttgt     120

attatttttc ctcatatatg tgtataggtt tatacggatg atttaattat tacttcacca     180

ccctttattt caggctgata tcttagcctt gttactagtt agaaaaagac atttttgctg     240

tcagtcactg tcaagagatt cttttgctgg catttcttcc agaagcaaaa agagcgatgc     300

gtcttttccg ctgaaccgtt ccagcaaaaa agactaccaa cgcaatatgg attgtcagaa     360

tcatataaaa gagaagcaaa taactccttg tcttgtatca attgcattat aatatcttct     420

tgttagtgca atatcatata gaagtcatcg aaatagatat taagaaaaac aaactgtaca     480

atcaatcaat caatcatcac ataaa                                           505


<210> 26
<211> 500
<212> DNA
<213> Candida glabrata


<220> 
<223> pCUP1.Cgla

<220> 
<223> pCUP1.Cgla

<400> 26
cacaccacac aaccgtcagc accccggctg tacgtctgtg aaggctgcgg tatagacacg      60

gactgcgata cagaactcat gacttatatc tgtagactcc tctgcttcaa tgcgaactcc     120

aggatcaccg aatagcatgc gatgagctgt tgattcttat atataattat ctattgcatt     180

ttttttttaa tgctgcatgg gggggcctag taaatcaccc gtacaagtca cgcgtgagag     240

aaagagaagg gccctttcgt cgtggaagcg tggatcgtga gcgacctgtt tctaaatata     300

gcttttgggt aggatattat attaagtgaa attttattag agggtaaatg tatgtgaaag     360

ttatgtataa tatgttgcta aattagcgat cgtgaatgca tagaatctaa tcgttataga     420

aaaccgcaac ttgtgctgtt ttgttgtgtt ttcttgtcgt ttttttatat tatttatcta     480

gtattttgct ttagttgtta                                                 500


<210> 27
<211> 425
<212> DNA
<213> Saccharomyces bayanus


<220> 
<223> pCUP1.Sba

<220> 
<223> pCUP1.Sba

<400> 27
agaaggaggg gtcctattac caatacttgg acgctatacg tgcatatgta catgtacgta      60

tctgtattta aacacttttg tattattttc tttatatatg tgtataggtt tacatggttg     120

acttttatca ttgtttgtgc acatttgcaa tggccatttt tttgtttttg agaaaggtat     180

tattgctgtc actattcgag atgcttttgc tgacattcct cctagaagcc aaaaggccga     240

tgcgtttttt ccgctgagag gataccagca aaaaaagcta ccagtacaag atgggacggc     300

aaaagcgtat aaaagaagaa gcaaaatgac cagatatgct ttcaatttca tcaatgtttc     360

tttctccctg ttatgatcca gaagaataat caaaagcaaa acatctattc aatcaatctc     420

ataaa                                                                 425


<210> 28
<211> 741
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU1

<220> 
<223> pACU1

<400> 28
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tcgaaaaaga catttttgct gtcagtcact gtcaagagat tcttttgctg gcatttcttc     420

cagaagcaaa aagagcgatg cgtcttttcc gctgaaccgt tccagcaaaa aagactacca     480

acgaattcta attaagttag tcaaggcgcc atcctcatga aaactgtgta acataataac     540

cgaagtgtcg aaaaggtggc accttgtcca attgaacacg ctcgatgaaa aaaataagat     600

atatataagg ttaagtaaag cgtctgttag aaaggaagtt tttccttttt cttgctctct     660

tgtcttttca tctactattt ccttcgtgta atacagggtc gtcagataca tagatacaat     720

tctattaccc ccatccatac a                                               741


<210> 29
<211> 757
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU2

<220> 
<223> pACU2

<400> 29
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccgaatt cgaaaaagac atttttgctg tcagtcactg     360

tcaagagatt cttttgctgg catttcttcc agaagcaaaa agagcgatgc gtcttttccg     420

ctgaaccgtt ccagcaaaaa agactaccaa cgaattccac gtgaagctgt cgatattggg     480

gaactgtggt ggttggcaaa tgactaatta agttagtcaa ggcgccatcc tcatgaaaac     540

tgtgtaacat aataaccgaa gtgtcgaaaa ggtggcacct tgtccaattg aacacgctcg     600

atgaaaaaaa taagatatat ataaggttaa gtaaagcgtc tgttagaaag gaagtttttc     660

ctttttcttg ctctcttgtc ttttcatcta ctatttcctt cgtgtaatac agggtcgtca     720

gatacataga tacaattcta ttacccccat ccataca                              757


<210> 30
<211> 498
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU3p

<220> 
<223> pACU3p

<400> 30
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attcgaaaaa gacatttttg ctgtcagtca ctgtcaagag     180

attcttttgc tggcatttct tccagaagca aaaagagcga tgcgtctttt ccgctgaacc     240

gttccagcaa aaaagactac caacgaattc ggatgataat gcgattagtt ttttagcctt     300

atttctgggg taattaatca gcgaagcgat gatttttgat ctattaacag atatataaat     360

ggaaaagctg cataaccact ttaactaata ctttcaacat tttcagtttg tattacttct     420

tattcaaatg tcataaaagt atcaacaaaa aattgttaat atacctctat actttaacgt     480

caaggagaaa aaactata                                                   498


<210> 31
<211> 498
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU4p

<220> 
<223> pACU4p

<400> 31
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attcgttggt agtctttttt gctggaacgg ttcagcggaa     180

aagacgcatc gctctttttg cttctggaag aaatgccagc aaaagaatct cttgacagtg     240

actgacagca aaaatgtctt tttcgaattc ggatgataat gcgattagtt ttttagcctt     300

atttctgggg taattaatca gcgaagcgat gatttttgat ctattaacag atatataaat     360

ggaaaagctg cataaccact ttaactaata ctttcaacat tttcagtttg tattacttct     420

tattcaaatg tcataaaagt atcaacaaaa aattgttaat atacctctat actttaacgt     480

caaggagaaa aaactata                                                   498


<210> 32
<211> 530
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU5

<220> 
<223> pACU5

<400> 32
ggaggacgaa acaaaaaagt gaaaaaaaat gaaaattttt ttggaaaacc aagaaatgaa      60

ttatatttcc gtgtgagacg acatcgtcga atatgattca gggtaacagt attgatgtaa     120

tcaatttcct acctgaatct aaaattcccg gaattcgaaa aagacatttt tgctgtcagt     180

cactgtcaag agattctttt gctggcattt cttccagaag caaaaagagc gatgcgtctt     240

ttccgctgaa ccgttccagc aaaaaagact accaacgaat tccgagcaga tccgccaggc     300

gtgtatatat agcgtggatg gccaggcaac tttagtgctg acacatacag gcatatatat     360

atgtgtgcga cgacacatga tcatatggca tgcatgtgct ctgtatgtat ataaaactct     420

tgttttcttc ttttctctaa atattctttc cttatacatt aggacctttg cagcataaat     480

tactatactt ctatagacac acaaacacaa atacacacac taaattaata                530


<210> 33
<211> 867
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU6

<220> 
<223> pACU6

<400> 33
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tcgaaaaaga catttttgct gtcagtcact gtcaagagat tcttttgctg gcatttcttc     420

cagaagcaaa aagagcgatg cgtcttttcc gctgaaccgt tccagcaaaa aagactacca     480

acgaattcga aaaagacatt tttgctgtca gtcactgtca agagattctt ttgctggcat     540

ttcttccaga agcaaaaaga gcgatgcgtc ttttccgctg aaccgttcca gcaaaaaaga     600

ctaccaacga attctaatta agttagtcaa ggcgccatcc tcatgaaaac tgtgtaacat     660

aataaccgaa gtgtcgaaaa ggtggcacct tgtccaattg aacacgctcg atgaaaaaaa     720

taagatatat ataaggttaa gtaaagcgtc tgttagaaag gaagtttttc ctttttcttg     780

ctctcttgtc ttttcatcta ctatttcctt cgtgtaatac agggtcgtca gatacataga     840

tacaattcta ttacccccat ccataca                                         867


<210> 34
<211> 867
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU7

<220> 
<223> pACU7

<400> 34
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tcgttggtag tcttttttgc tggaacggtt cagcggaaaa gacgcatcgc tctttttgct     420

tctggaagaa atgccagcaa aagaatctct tgacagtgac tgacagcaaa aatgtctttt     480

tcgaattcgt tggtagtctt ttttgctgga acggttcagc ggaaaagacg catcgctctt     540

tttgcttctg gaagaaatgc cagcaaaaga atctcttgac agtgactgac agcaaaaatg     600

tctttttcga attctaatta agttagtcaa ggcgccatcc tcatgaaaac tgtgtaacat     660

aataaccgaa gtgtcgaaaa ggtggcacct tgtccaattg aacacgctcg atgaaaaaaa     720

taagatatat ataaggttaa gtaaagcgtc tgttagaaag gaagtttttc ctttttcttg     780

ctctcttgtc ttttcatcta ctatttcctt cgtgtaatac agggtcgtca gatacataga     840

tacaattcta ttacccccat ccataca                                         867


<210> 35
<211> 1119
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU8

<220> 
<223> pACU8

<400> 35
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tcgaaaaaga catttttgct gtcagtcact gtcaagagat tcttttgctg gcatttcttc     420

cagaagcaaa aagagcgatg cgtcttttcc gctgaaccgt tccagcaaaa aagactacca     480

acgaattcga aaaagacatt tttgctgtca gtcactgtca agagattctt ttgctggcat     540

ttcttccaga agcaaaaaga gcgatgcgtc ttttccgctg aaccgttcca gcaaaaaaga     600

ctaccaacga attcgaaaaa gacatttttg ctgtcagtca ctgtcaagag attcttttgc     660

tggcatttct tccagaagca aaaagagcga tgcgtctttt ccgctgaacc gttccagcaa     720

aaaagactac caacgaattc gaaaaagaca tttttgctgt cagtcactgt caagagattc     780

ttttgctggc atttcttcca gaagcaaaaa gagcgatgcg tcttttccgc tgaaccgttc     840

cagcaaaaaa gactaccaac gaattctaat taagttagtc aaggcgccat cctcatgaaa     900

actgtgtaac ataataaccg aagtgtcgaa aaggtggcac cttgtccaat tgaacacgct     960

cgatgaaaaa aataagatat atataaggtt aagtaaagcg tctgttagaa aggaagtttt    1020

tcctttttct tgctctcttg tcttttcatc tactatttcc ttcgtgtaat acagggtcgt    1080

cagatacata gatacaattc tattaccccc atccataca                           1119


<210> 36
<211> 624
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU9

<220> 
<223> pACU9

<400> 36
tatagttttt tctccttgac gttaaagtat agaggtatat taacaatttt ttgttgatac      60

ttttatgaca tttgaataag aagtaataca aactgaaaat gttgaaagta ttagttaaag     120

tggttatgca gcttttccat ttatatatct gttaatagat caaaaatcat cgcttcgctg     180

attaattacc ccagaaataa ggctaaaaaa ctaatcgcat tatcatccga attcgaaaaa     240

gacatttttg ctgtcagtca ctgtcaagag attcttttgc tggcatttct tccagaagca     300

aaaagagcga tgcgtctttt ccgctgaacc gttccagcaa aaaagactac caacgaattc     360

gaaaaagaca tttttgctgt cagtcactgt caagagattc ttttgctggc atttcttcca     420

gaagcaaaaa gagcgatgcg tcttttccgc tgaaccgttc cagcaaaaaa gactaccaac     480

gaattcgggc tctttacatt tccacaacat ataagtaaga ttagatatgg atatgtatat     540

ggtggtaatg ccatgtaata tgattattaa acttctttgc gtccatccaa aaaaaaagta     600

agaatttttg aaaattcaat ataa                                            624


<210> 37
<211> 876
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU10p

<220> 
<223> pACU10p

<400> 37
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attggttggt agtctttttt gctggaacgg ttcagcggaa     180

aagacgcatc gctctttttg cttctggaag aaatgccagc aaaagaatct cttgacagtg     240

actgacagca aaaatgtctt tttcgaattc gttggtagtc ttttttgctg gaacggttca     300

gcggaaaaga cgcatcgctc tttttgcttc tggaagaaat gccagcaaaa gaatctcttg     360

acagtgactg acagcaaaaa tgtctttttc gaattcgttg gtagtctttt ttgctggaac     420

ggttcagcgg aaaagacgca tcgctctttt tgcttctgga agaaatgcca gcaaaagaat     480

ctcttgacag tgactgacag caaaaatgtc tttttcgaat tcgttggtag tcttttttgc     540

tggaacggtt cagcggaaaa gacgcatcgc tctttttgct tctggaagaa atgccagcaa     600

aagaatctct tgacagtgac tgacagcaaa aatgtctttt tccaattcgg atgataatgc     660

gattagtttt ttagccttat ttctggggta attaatcagc gaagcgatga tttttgatct     720

attaacagat atataaatgg aaaagctgca taaccacttt aactaatact ttcaacattt     780

tcagtttgta ttacttctta ttcaaatgtc ataaaagtat caacaaaaaa ttgttaatat     840

acctctatac tttaacgtca aggagaaaaa actata                               876


<210> 38
<211> 633
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU11

<220> 
<223> pACU11

<400> 38
gctcagcatc tgcttcttcc caaagatgaa cgcggcgtta tgtcactaac gacgtgcacc      60

aacttgcggg aattcgaaaa agacattttt gctgtcagtc actgtcaaga gattcttttg     120

ctggcatttc ttccagaagc aaaaagagcg atgcgtcttt tccgctgaac cgttccagca     180

aaaaagacta ccaacgaatt ccaccgcacg ccttttttct gaagcccact ttcgtggact     240

ttgccatata tgcaaaattc atgaagtgtg ataccaagtc agcatacacc tcactagggt     300

agtttctttg gttgtattga tcatttggtt catcgtggtt cattaatttt ttttctccat     360

tgctttctgg ctttgatctt actatcattt ggatttttgt cgaaggttgt agaattgtat     420

gtgacaagtg gcaccaagca tatataaaaa aaaaaagcat tatcttccta ccagagttga     480

ttgttaaaaa cgtatttata gcaaacgcaa ttgtaattaa ttcttatttt gtatcttttc     540

ttcccttgtc tcaatctttt atttttattt tatttttctt ttcttagttt ctttcataac     600

accaagcaac taatactata acatacaata ata                                  633


<210> 39
<211> 1119
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU12

<220> 
<223> pACU12

<400> 39
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tggttggtag tcttttttgc tggaacggtt cagcggaaaa gacgcatcgc tctttttgct     420

tctggaagaa atgccagcaa aagaatctct tgacagtgac tgacagcaaa aatgtctttt     480

tcgaattcgt tggtagtctt ttttgctgga acggttcagc ggaaaagacg catcgctctt     540

tttgcttctg gaagaaatgc cagcaaaaga atctcttgac agtgactgac agcaaaaatg     600

tctttttcga attcgttggt agtctttttt gctggaacgg ttcagcggaa aagacgcatc     660

gctctttttg cttctggaag aaatgccagc aaaagaatct cttgacagtg actgacagca     720

aaaatgtctt tttcgaattc gttggtagtc ttttttgctg gaacggttca gcggaaaaga     780

cgcatcgctc tttttgcttc tggaagaaat gccagcaaaa gaatctcttg acagtgactg     840

acagcaaaaa tgtctttttc caattctaat taagttagtc aaggcgccat cctcatgaaa     900

actgtgtaac ataataaccg aagtgtcgaa aaggtggcac cttgtccaat tgaacacgct     960

cgatgaaaaa aataagatat atataaggtt aagtaaagcg tctgttagaa aggaagtttt    1020

tcctttttct tgctctcttg tcttttcatc tactatttcc ttcgtgtaat acagggtcgt    1080

cagatacata gatacaattc tattaccccc atccataca                           1119


<210> 40
<211> 1497
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU13

<220> 
<223> pACU13

<400> 40
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tggttggtag tcttttttgc tggaacggtt cagcggaaaa gacgcatcgc tctttttgct     420

tctggaagaa atgccagcaa aagaatctct tgacagtgac tgacagcaaa aatgtctttt     480

tcgaattcgt tggtagtctt ttttgctgga acggttcagc ggaaaagacg catcgctctt     540

tttgcttctg gaagaaatgc cagcaaaaga atctcttgac agtgactgac agcaaaaatg     600

tctttttcga attcgttggt agtctttttt gctggaacgg ttcagcggaa aagacgcatc     660

gctctttttg cttctggaag aaatgccagc aaaagaatct cttgacagtg actgacagca     720

aaaatgtctt tttcgaattc gttggtagtc ttttttgctg gaacggttca gcggaaaaga     780

cgcatcgctc tttttgcttc tggaagaaat gccagcaaaa gaatctcttg acagtgactg     840

acagcaaaaa tgtctttttc gaattcgttg gtagtctttt ttgctggaac ggttcagcgg     900

aaaagacgca tcgctctttt tgcttctgga agaaatgcca gcaaaagaat ctcttgacag     960

tgactgacag caaaaatgtc tttttcgaat tcgttggtag tcttttttgc tggaacggtt    1020

cagcggaaaa gacgcatcgc tctttttgct tctggaagaa atgccagcaa aagaatctct    1080

tgacagtgac tgacagcaaa aatgtctttt tcgaattcgt tggtagtctt ttttgctgga    1140

acggttcagc ggaaaagacg catcgctctt tttgcttctg gaagaaatgc cagcaaaaga    1200

atctcttgac agtgactgac agcaaaaatg tctttttcca attctaatta agttagtcaa    1260

ggcgccatcc tcatgaaaac tgtgtaacat aataaccgaa gtgtcgaaaa ggtggcacct    1320

tgtccaattg aacacgctcg atgaaaaaaa taagatatat ataaggttaa gtaaagcgtc    1380

tgttagaaag gaagtttttc ctttttcttg ctctcttgtc ttttcatcta ctatttcctt    1440

cgtgtaatac agggtcgtca gatacataga tacaattcta ttacccccat ccataca       1497


<210> 41
<211> 1011
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU14

<220> 
<223> pACU14

<400> 41
gctcagcatc tgcttcttcc caaagatgaa cgcggcgtta tgtcactaac gacgtgcacc      60

aacttgcggg aattggaaaa agacattttt gctgtcagtc actgtcaaga gattcttttg     120

ctggcatttc ttccagaagc aaaaagagcg atgcgtcttt tccgctgaac cgttccagca     180

aaaaagacta ccaacgaatt cgaaaaagac atttttgctg tcagtcactg tcaagagatt     240

cttttgctgg catttcttcc agaagcaaaa agagcgatgc gtcttttccg ctgaaccgtt     300

ccagcaaaaa agactaccaa cgaattcgaa aaagacattt ttgctgtcag tcactgtcaa     360

gagattcttt tgctggcatt tcttccagaa gcaaaaagag cgatgcgtct tttccgctga     420

accgttccag caaaaaagac taccaacgaa ttcgaaaaag acatttttgc tgtcagtcac     480

tgtcaagaga ttcttttgct ggcatttctt ccagaagcaa aaagagcgat gcgtcttttc     540

cgctgaaccg ttccagcaaa aaagactacc aaccaattcc accgcacgcc ttttttctga     600

agcccacttt cgtggacttt gccatatatg caaaattcat gaagtgtgat accaagtcag     660

catacacctc actagggtag tttctttggt tgtattgatc atttggttca tcgtggttca     720

ttaatttttt ttctccattg ctttctggct ttgatcttac tatcatttgg atttttgtcg     780

aaggttgtag aattgtatgt gacaagtggc accaagcata tataaaaaaa aaaagcatta     840

tcttcctacc agagttgatt gttaaaaacg tatttatagc aaacgcaatt gtaattaatt     900

cttattttgt atcttttctt cccttgtctc aatcttttat ttttatttta tttttctttt     960

cttagtttct ttcataacac caagcaacta atactataac atacaataat a             1011


<210> 42
<211> 398
<212> DNA
<213> Artificial Sequence


<220> 
<223> pACU15

<220> 
<223> pACU15

<400> 42
tatagttttt tctccttgac gttaaagtat agaggtatat taacaatttt ttgttgatac      60

ttttatgaca tttgaataag aagtaataca aactgaaaat gttgaaagta ttagttaaag     120

tggttatgca gcttttccat ttatatatct gttaatagat caaaaatcat cgcttcgctg     180

attaattacc ccagaaataa ggctaaaaaa ctaatcgcat tatcatccga attcgttggt     240

agtctttttt gctggaacgg ttcagcggaa aagacgcatc gctctttttg cttctggaag     300

aaatgccagc aaaagaatct cttgacagtg actgacagca aaaatgtctt tttcgaattc     360

gggctcttta catttccaca acatataagt aagattag                             398


<210> 43
<211> 428
<212> DNA
<213> Artificial Sequence


<220> 
<223> pGAL/CUP1p

<220> 
<223> pGAL/CUP1p

<400> 43
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attcgaaaaa gacatttttg ctgtcagtca ctgtcaagag     180

attcttttgc tggcatttct tccagaagca aaaagagcga tgcgtctttt ccgctgaacc     240

gttccagcaa aaaagactac caacgcaata tggattgtca gaatcatata aaagagaagc     300

aaataactcc ttgtcttgta tcaattgcat tataatatct tcttgttagt gcaatatcat     360

atagaagtca tcgaaataga tattaagaaa aacaaactgt acaatcaatc aatcaatcat     420

cacataaa                                                              428


<210> 44
<211> 518
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pCRS5

<220> 
<223> pCRS5

<400> 44
gtggacgaaa agacataact gcagaagtac agctgccttt atttcttgtg gtcatttatt      60

gcttttattt tcaagtcaga tatacaagaa aatcaaatcc catcgtcaac gtcacgtata     120

aacgattaat ttacagtaat accatactct accaacatta ttttagtccg acgttcagtc     180

ctgtaggtgt tccaaatcct tctggcattg acttctgtgc agaaaccctt caaaatgagt     240

tccactttac gtcagatcgc ataacaaccg gtcatatatt tttttctttt gctaaacccc     300

ctactgcaag cacttttaag aaaaagaaca ataaatgcgt ctttattgct gtgtggaagt     360

gatttttgtc tttcggacaa aaaaaggata gggatgcgag agggctgtga agtagtgatc     420

aagcggggcc tatataagaa gggcgcacat cgtcccccct aagaatagcg aagcgatatt     480

acactgaaca ctacaatgtc aaatagtact caataaat                             518


<210> 45
<211> 510
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pCHA1

<220> 
<223> pCHA1

<400> 45
gatctctgct gacgttgtat ccacagatct aattgcaaga tagcctcttg cgaccttatt      60

aaaagcctct ccgtgatatc ctctagggct tgggttgcca ttaatcgatg tgtccttgtt     120

tccttatgcg agctgtttct tatctatctt atggtcccat tctttactgc actgtttaca     180

ttttgatcaa ttgcgaaatg ttcctactat ttttcttttt ctcttttcgc gagtactaat     240

caccgcgaac ggaaactaat gagtcctctg cgcggagaca tgattccgca tgggcggctc     300

ctgttaagcc ccagcggaaa tgtaattcca ctgagtgtca ttaaatagtg ccaaagcttt     360

atcaaattgt ttgcgatgag ataagataaa agggacaata tgaggaggaa cacaggtata     420

taaatatcgc caaataaaag gaaaatgttt atacagtttt ctctttttta agtgctggat     480

agacaagaga caggaaaatt aaccagcgag                                      510


<210> 46
<211> 601
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pCTR1

<220> 
<223> pCTR1

<400> 46
caagtccgat tgttcctctt caggagcttc ctgaaccaaa ctttttccgc aaggccgcat      60

tttgaaccgt attttgctcg ttccagcctt tccacgtttt tgttatctaa gcaacttggc     120

acatttccct actatactac aaaccgatac gtaaatactt ccctaaatag catatgaatt     180

attcagtaat ttttaaggat cgaaactgca cctcaactat tcgttactgt ggttatgttc     240

tcatgtattg atgcaaatca tgggatattt gctcaagacg acggtaaaat gagcaaaaat     300

ggcacgatcc tgaaaagagc acttttcaag attcgggcta caaaatgcaa cataaaaaat     360

gttgtattgt catctcgaca gggtcttgta tgttttattc ctcttatgat tagttcacat     420

tagtaaaaca gatacgcagt gtgctcttaa taaacaacta ctccatagct ttatttgcat     480

aacaaaactt ttaagcacaa acttaaacag gtggagtaat agttcggcgg cgactcaaat     540

tacatttgtt ggaagaatcg aatagaaaat aaaaaaaagt gtattatatt tgacattcaa     600

a                                                                     601


<210> 47
<211> 522
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pCTR3

<220> 
<223> pCTR3

<400> 47
gatgtgatga caaaacctct tccgataaaa acatttaaac tattaacaaa caaatggatt      60

cattagatct attacattat gggtggtatg ttggaataaa aatcaactat catctactaa     120

ctagtattta cgttactagt atattatcat atacggtgtt agaagatgac gcaaatgatg     180

agaaatagtc atctaaatta gtggaagctg aaacgcaagg attgataatg taataggatc     240

aatgaatatt aacatataaa acgatgataa taatatttat agaattgtgt agaattgcag     300

attccctttt atggattcct aaatcctcca ggagaacttc tagtatatct acatacctaa     360

tattattgcc ttattaaaaa tggaatccca acaattacat caaaatccac attctcttca     420

cttctccgat agacttgtaa tttatcttat ttcatttcct aacactttga tcgaagaaga     480

gggataacaa cagacgaaaa cacatttaag ggctatacaa ag                        522


<210> 48
<211> 675
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR1

<220> 
<223> pCUR1

<400> 48
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tgtcatggga tatttgctca agacgacggt aaaatgagca aatatggcac gatcctcaat     420

tctaattaag ttagtcaagg cgccatcctc atgaaaactg tgtaacataa taaccgaagt     480

gtcgaaaagg tggcaccttg tccaattgaa cacgctcgat gaaaaaaata agatatatat     540

aaggttaagt aaagcgtctg ttagaaagga agtttttcct ttttcttgct ctcttgtctt     600

ttcatctact atttccttcg tgtaatacag ggtcgtcaga tacatagata caattctatt     660

acccccatcc ataca                                                      675


<210> 49
<211> 674
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR2

<220> 
<223> pCUR2

<400> 49
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgatt     360

gaggatcgtg ccatatttgc tcattttacc gtcgtcttga gcaaatatcc catgacaatt     420

ctaattaagt tagtcaaggc gccatcctca tgaaaactgt gtaacataat aaccgaagtg     480

tcgaaaaggt ggcaccttgt ccaattgaac acgctcgatg aaaaaaataa gatatatata     540

aggttaagta aagcgtctgt tagaaaggaa gtttttcctt tttcttgctc tcttgtcttt     600

tcatctacta tttccttcgt gtaatacagg gtcgtcagat acatagatac aattctatta     660

cccccatcca taca                                                       674


<210> 50
<211> 794
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR3

<220> 
<223> pCUR3

<400> 50
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

taggatcgtg ccatatttgc tcattttacc gtcgtcttga gcaaatatcc catgacaatt     420

gaggatcgtg ccatatttgc tcattttacc gtcgtcttga gcaaatatcc catgacaatt     480

gaggatcgtg ccatatttgc tcattttacc gtcgtcttga gcaaatatcc catgacaatt     540

ctaattaagt tagtcaaggc gccatcctca tgaaaactgt gtaacataat aaccgaagtg     600

tcgaaaaggt ggcaccttgt ccaattgaac acgctcgatg aaaaaaataa gatatatata     660

aggttaagta aagcgtctgt tagaaaggaa gtttttcctt tttcttgctc tcttgtcttt     720

tcatctacta tttccttcgt gtaatacagg gtcgtcagat acatagatac aattctatta     780

cccccatcca taca                                                       794


<210> 51
<211> 850
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR4

<220> 
<223> pCUR4

<400> 51
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tgtcatggga tatttgctca agacgacggt aaaatgagca aatatggcac gatcctcaat     420

tgtcatggga tatttgctca agacgacggt aaaatgagca aatatggcac gatcctcaat     480

gtcatgggat atttgctcaa gacgacggta aaatgagcaa atatggcacg atcctcaatt     540

gtcatgggat atttgctcaa gacgacggta aaatgagcaa atatcccatg acaattctaa     600

ttaagttagt caaggcgcca tcctcatgaa aactgtgtaa cataataacc gaagtgtcga     660

aaaggtggca ccttgtccaa ttgaacacgc tcgatgaaaa aaataagata tatataaggt     720

taagtaaagc gtctgttaga aaggaagttt ttcctttttc ttgctctctt gtcttttcat     780

ctactatttc cttcgtgtaa tacagggtcg tcagatacat agatacaatt ctattacccc     840

catccataca                                                            850


<210> 52
<211> 491
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR5p

<220> 
<223> pCUR5p

<400> 52
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attgtcatgg gatatttgct caagacgacg gtaaaatgag     180

caaatatggc acgatcctca attgtcatgg gatatttgct caagacgacg gtaaaatgag     240

caaatatggc acgatcccaa ttcggatgat aatgcgatta gttttttagc cttatttctg     300

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatggaaaag     360

ctgcataacc actttaacta atactttcaa cattttcagt ttgtattact tcttattcaa     420

atgtcataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     480

aaaaaactat a                                                          491


<210> 53
<211> 833
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR6

<220> 
<223> pCUR6

<400> 53
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccgaatt gaggatcgtg ccatatttgc tcattttacc     360

gtcgtcttga gcaaatatcc catgacaatt gaggatcgtg ccatatttgc tcattttacc     420

gtcgtcttga gcaaatatcc catgacaatt gaggatcgtg ccatatttgc tcattttacc     480

gtcgtcttga gcaaatatcc catgacaatt catgatcgca aaatggcaaa tggcacgtga     540

agctgtcgat attggggaac tgtggtggtt ggcaaatgac taattaagtt agtcaaggcg     600

ccatcctcat gaaaactgtg taacataata accgaagtgt cgaaaaggtg gcaccttgtc     660

caattgaaca cgctcgatga aaaaaataag atatatataa ggttaagtaa agcgtctgtt     720

agaaaggaag tttttccttt ttcttgctct cttgtctttt catctactat ttccttcgtg     780

taatacaggg tcgtcagata catagataca attctattac ccccatccat aca            833


<210> 54
<211> 803
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR7

<220> 
<223> pCUR7

<400> 54
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaattcag gatcgtgcca     240

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     300

tatttgctca ttttaccgtc gtcttgagca aatatcccat gagaattctt cctgtcttcc     360

tattgattgc agcttccaat ttcgtcacac aacaaggtcc tagcgacggc tcacaggttt     420

tgtaacaagc aatcgaaggt tctggaatgg cgggaaaggg tttagtacca catgctatga     480

tgcccactgt gatctccaga gcaaagttcg ttcgatcgta ctgttactct ctctctttca     540

aacagaattg tccgaatcgt gtgacaacaa cagcctgttc tcacacactc ttttcttcta     600

accaaggggg tggtttagtt tagtagaacc tcgtgaaact tacatttaca tatatataaa     660

cttgcataaa ttggtcaatg caagaaatac atatttggtc ttttctaatt cgtagttttt     720

caagttctta gatgctttct ttttctcttt tttacagatc atcaaggaag taattatcta     780

ctttttacaa caaatataaa aca                                             803


<210> 55
<211> 863
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR8

<220> 
<223> pCUR8

<400> 55
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaattcag gatcgtgcca     240

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     300

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     360

tatttgctca ttttaccgtc gtcttgagca aatatcccat gagaattctt cctgtcttcc     420

tattgattgc agcttccaat ttcgtcacac aacaaggtcc tagcgacggc tcacaggttt     480

tgtaacaagc aatcgaaggt tctggaatgg cgggaaaggg tttagtacca catgctatga     540

tgcccactgt gatctccaga gcaaagttcg ttcgatcgta ctgttactct ctctctttca     600

aacagaattg tccgaatcgt gtgacaacaa cagcctgttc tcacacactc ttttcttcta     660

accaaggggg tggtttagtt tagtagaacc tcgtgaaact tacatttaca tatatataaa     720

cttgcataaa ttggtcaatg caagaaatac atatttggtc ttttctaatt cgtagttttt     780

caagttctta gatgctttct ttttctcttt tttacagatc atcaaggaag taattatcta     840

ctttttacaa caaatataaa aca                                             863


<210> 56
<211> 863
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR9

<220> 
<223> pCUR9

<400> 56
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaattctc atgggatatt     240

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     300

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     360

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctgaattctt cctgtcttcc     420

tattgattgc agcttccaat ttcgtcacac aacaaggtcc tagcgacggc tcacaggttt     480

tgtaacaagc aatcgaaggt tctggaatgg cgggaaaggg tttagtacca catgctatga     540

tgcccactgt gatctccaga gcaaagttcg ttcgatcgta ctgttactct ctctctttca     600

aacagaattg tccgaatcgt gtgacaacaa cagcctgttc tcacacactc ttttcttcta     660

accaaggggg tggtttagtt tagtagaacc tcgtgaaact tacatttaca tatatataaa     720

cttgcataaa ttggtcaatg caagaaatac atatttggtc ttttctaatt cgtagttttt     780

caagttctta gatgctttct ttttctcttt tttacagatc atcaaggaag taattatcta     840

ctttttacaa caaatataaa aca                                             863


<210> 57
<211> 923
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR10

<220> 
<223> pCUR10

<400> 57
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaattctc atgggatatt     240

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     300

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     360

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     420

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctgaattctt cctgtcttcc     480

tattgattgc agcttccaat ttcgtcacac aacaaggtcc tagcgacggc tcacaggttt     540

tgtaacaagc aatcgaaggt tctggaatgg cgggaaaggg tttagtacca catgctatga     600

tgcccactgt gatctccaga gcaaagttcg ttcgatcgta ctgttactct ctctctttca     660

aacagaattg tccgaatcgt gtgacaacaa cagcctgttc tcacacactc ttttcttcta     720

accaaggggg tggtttagtt tagtagaacc tcgtgaaact tacatttaca tatatataaa     780

cttgcataaa ttggtcaatg caagaaatac atatttggtc ttttctaatt cgtagttttt     840

caagttctta gatgctttct ttttctcttt tttacagatc atcaaggaag taattatcta     900

ctttttacaa caaatataaa aca                                             923


<210> 58
<211> 983
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR11

<220> 
<223> pCUR11

<400> 58
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaattctc atgggatatt     240

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     300

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     360

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     420

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     480

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctgaattctt cctgtcttcc     540

tattgattgc agcttccaat ttcgtcacac aacaaggtcc tagcgacggc tcacaggttt     600

tgtaacaagc aatcgaaggt tctggaatgg cgggaaaggg tttagtacca catgctatga     660

tgcccactgt gatctccaga gcaaagttcg ttcgatcgta ctgttactct ctctctttca     720

aacagaattg tccgaatcgt gtgacaacaa cagcctgttc tcacacactc ttttcttcta     780

accaaggggg tggtttagtt tagtagaacc tcgtgaaact tacatttaca tatatataaa     840

cttgcataaa ttggtcaatg caagaaatac atatttggtc ttttctaatt cgtagttttt     900

caagttctta gatgctttct ttttctcttt tttacagatc atcaaggaag taattatcta     960

ctttttacaa caaatataaa aca                                             983


<210> 59
<211> 1043
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR12

<220> 
<223> pCUR12

<400> 59
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaattcag gatcgtgcca     240

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     300

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     360

tatttgctca ttttaccgtc gtcttgagca aatatcccat gagaattcag gatcgtgcca     420

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     480

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     540

tatttgctca ttttaccgtc gtcttgagca aatatcccat gagaattctt cctgtcttcc     600

tattgattgc agcttccaat ttcgtcacac aacaaggtcc tagcgacggc tcacaggttt     660

tgtaacaagc aatcgaaggt tctggaatgg cgggaaaggg tttagtacca catgctatga     720

tgcccactgt gatctccaga gcaaagttcg ttcgatcgta ctgttactct ctctctttca     780

aacagaattg tccgaatcgt gtgacaacaa cagcctgttc tcacacactc ttttcttcta     840

accaaggggg tggtttagtt tagtagaacc tcgtgaaact tacatttaca tatatataaa     900

cttgcataaa ttggtcaatg caagaaatac atatttggtc ttttctaatt cgtagttttt     960

caagttctta gatgctttct ttttctcttt tttacagatc atcaaggaag taattatcta    1020

ctttttacaa caaatataaa aca                                            1043


<210> 60
<211> 1043
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR13

<220> 
<223> pCUR13

<400> 60
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaattctc atgggatatt     240

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     300

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     360

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctgaattctc atgggatatt     420

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     480

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     540

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctgaattctt cctgtcttcc     600

tattgattgc agcttccaat ttcgtcacac aacaaggtcc tagcgacggc tcacaggttt     660

tgtaacaagc aatcgaaggt tctggaatgg cgggaaaggg tttagtacca catgctatga     720

tgcccactgt gatctccaga gcaaagttcg ttcgatcgta ctgttactct ctctctttca     780

aacagaattg tccgaatcgt gtgacaacaa cagcctgttc tcacacactc ttttcttcta     840

accaaggggg tggtttagtt tagtagaacc tcgtgaaact tacatttaca tatatataaa     900

cttgcataaa ttggtcaatg caagaaatac atatttggtc ttttctaatt cgtagttttt     960

caagttctta gatgctttct ttttctcttt tttacagatc atcaaggaag taattatcta    1020

ctttttacaa caaatataaa aca                                            1043


<210> 61
<211> 1223
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR14

<220> 
<223> pCUR14

<400> 61
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaattctc atgggatatt     240

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     300

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     360

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctgaattctc atgggatatt     420

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     480

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     540

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctgaattctc atgggatatt     600

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     660

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctcaattgtc atgggatatt     720

tgctcaagac gacggtaaaa tgagcaaata tggcacgatc ctgaattctt cctgtcttcc     780

tattgattgc agcttccaat ttcgtcacac aacaaggtcc tagcgacggc tcacaggttt     840

tgtaacaagc aatcgaaggt tctggaatgg cgggaaaggg tttagtacca catgctatga     900

tgcccactgt gatctccaga gcaaagttcg ttcgatcgta ctgttactct ctctctttca     960

aacagaattg tccgaatcgt gtgacaacaa cagcctgttc tcacacactc ttttcttcta    1020

accaaggggg tggtttagtt tagtagaacc tcgtgaaact tacatttaca tatatataaa    1080

cttgcataaa ttggtcaatg caagaaatac atatttggtc ttttctaatt cgtagttttt    1140

caagttctta gatgctttct ttttctcttt tttacagatc atcaaggaag taattatcta    1200

ctttttacaa caaatataaa aca                                            1223


<210> 62
<211> 1283
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR15

<220> 
<223> pCUR15

<400> 62
gtgagtaagg aaagagtgag gaactatcgc atacctgcat ttaaagatgc cgatttgggc      60

gcgaatcctt tattttggct tcaccctcat actattatca gggccagaaa aaggaagtgt     120

ttccctcctt cttgaattga tgttaccctc ataaagcacg tggcctctta tcgagaaaga     180

aattaccgtc gctcgtgatt tgtttgcaaa aagaacaaaa ctgaattcag gatcgtgcca     240

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     300

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     360

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     420

tatttgctca ttttaccgtc gtcttgagca aatatcccat gagaattcag gatcgtgcca     480

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     540

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     600

tatttgctca ttttaccgtc gtcttgagca aatatcccat gagaattcag gatcgtgcca     660

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     720

tatttgctca ttttaccgtc gtcttgagca aatatcccat gacaattgag gatcgtgcca     780

tatttgctca ttttaccgtc gtcttgagca aatatcccat gagaattctt cctgtcttcc     840

tattgattgc agcttccaat ttcgtcacac aacaaggtcc tagcgacggc tcacaggttt     900

tgtaacaagc aatcgaaggt tctggaatgg cgggaaaggg tttagtacca catgctatga     960

tgcccactgt gatctccaga gcaaagttcg ttcgatcgta ctgttactct ctctctttca    1020

aacagaattg tccgaatcgt gtgacaacaa cagcctgttc tcacacactc ttttcttcta    1080

accaaggggg tggtttagtt tagtagaacc tcgtgaaact tacatttaca tatatataaa    1140

cttgcataaa ttggtcaatg caagaaatac atatttggtc ttttctaatt cgtagttttt    1200

caagttctta gatgctttct ttttctcttt tttacagatc atcaaggaag taattatcta    1260

ctttttacaa caaatataaa aca                                            1283


<210> 63
<211> 686
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR16

<220> 
<223> pCUR16

<400> 63
gctcagcatc tgcttcttcc caaagatgaa cgcggcgtta tgtcactaac gacgtgcacc      60

aacttgcggg aattctcatg ggatatttgc tcaagacgac ggtaaaatga gcaaatatgg     120

cacgatcctc aattgtcatg ggatatttgc tcaagacgac ggtaaaatga gcaaatatgg     180

cacgatcctc aatgtcatgg gatatttgct caagacgacg gtaaaatgag caaatatggc     240

acgatcctga attccaccgc acgccttttt tctgaagccc actttcgtgg actttgccat     300

atatgcaaaa ttcatgaagt gtgataccaa gtcagcatac acctcactag ggtagtttct     360

ttggttgtat tgatcatttg gttcatcgtg gttcattaat tttttttctc cattgctttc     420

tggctttgat cttactatca tttggatttt tgtcgaaggt tgtagaattg tatgtgacaa     480

gtggcaccaa gcatatataa aaaaaaaaag cattatcttc ctaccagagt tgattgttaa     540

aaacgtattt atagcaaacg caattgtaat taattcttat tttgtatctt ttcttccctt     600

gtctcaatct tttattttta ttttattttt cttttcttag tttctttcat aacaccaagc     660

aactaatact ataacataca ataata                                          686


<210> 64
<211> 747
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCUR17

<220> 
<223> pCUR17

<400> 64
gctcagcatc tgcttcttcc caaagatgaa cgcggcgtta tgtcactaac gacgtgcacc      60

aacttgcggg aattctcatg ggatatttgc tcaagacgac ggtaaaatga gcaaatatgg     120

cacgatcctc aattgtcatg ggatatttgc tcaagacgac ggtaaaatga gcaaatatgg     180

cacgatcctc aattctcatg ggatatttgc tcaagacgac ggtaaaatga gcaaatatgg     240

cacgatcctc aattctcatg ggatatttgc tcaagacgac ggtaaaatga gcaaatatgg     300

cacgatcctg aattccaccg cacgcctttt ttctgaagcc cactttcgtg gactttgcca     360

tatatgcaaa attcatgaag tgtgatacca agtcagcata cacctcacta gggtagtttc     420

tttggttgta ttgatcattt ggttcatcgt ggttcattaa ttttttttct ccattgcttt     480

ctggctttga tcttactatc atttggattt ttgtcgaagg ttgtagaatt gtatgtgaca     540

agtggcacca agcatatata aaaaaaaaaa gcattatctt cctaccagag ttgattgtta     600

aaaacgtatt tatagcaaac gcaattgtaa ttaattctta ttttgtatct tttcttccct     660

tgtctcaatc ttttattttt attttatttt tcttttctta gtttctttca taacaccaag     720

caactaatac tataacatac aataata                                         747


<210> 65
<211> 500
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pLYS1

<220> 
<223> pLYS1

<400> 65
gcaagttaac attagggaga acgtggggcc ttcctccatg agtgcagagc aattgaagat      60

gtttagaggt ttaaaggaga ataaccagtt gctggatagc tctgtgccag ctacagttta     120

tgccaaattg gcccttcatg gtattcctga cggtgttaat ggacagtact tgagctataa     180

tgaccctgcc ttggcggact ttatgccttg aggatagcag gtacatataa attgttacat     240

actaagtcga tgagtcaaaa aagactctta tacatttata cattttgcat tattattttt     300

tttttccagc ggaatttgga attccgctct caaccgccaa aattcccctg cgatttcagc     360

gacaaagagt cataaagtca tcctcgagaa accacgatga aatatataaa aagcccatct     420

tccctgacgg aaactggtat tttaggaggc ataccataag ataacaacga aaacgcttta     480

tttttcacac aaccgcaaaa                                                 500


<210> 66
<211> 650
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pLYS4

<220> 
<223> pLYS4

<400> 66
ttgaaaaatg cgaagttgaa gtgccataga agagaaacag cccacacagg ggagaagccc      60

actggaaagg gggcactgac caactttaaa taggaaacag aagataccac aagccagcga     120

tacaacagca ccaaacaccg aaaagaatag ccaaagctgt cctctggtgt tggaaaaact     180

ggaaaaaacg caactgcgtt ggctgctacg gtgaaaaatt ttcctatgac ttttttcact     240

gcttgttcgt gcgaaattac cgcaaacccg gtaaaatgta cacgtatcaa gtgataaaca     300

atttcgtgtc aagtgagcag aatggagcga tttggaaaaa aaaaattttt attgtttttt     360

cccccgggat tttgctcgag atgactgaaa ttttgtaatc gatgagtcta taccagaggc     420

agcaaatatc accaacatac acaggtatac acaatctcat gtccacacac acgtacagac     480

acgcacatat atatatatat atatatatcc ccataggtat ttatatatac aaaagaatcc     540

tcgtgtgttt gtgtgtgcaa tagctagttt tgcgctgcct cttatagtag acaatatcac     600

tttttcaata aaatagaact tgcaaggaaa caaaattgta tcgcttcaag                650


<210> 67
<211> 500
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pLYS9

<220> 
<223> pLYS9

<400> 67
acatatgcaa gagtcttatg tatcgtatct aagtgccacg taggggattc ccatcatttg      60

atgatttcca aatataatac ctgtagagag cggtggagca aaagtcaaat tttaatcgca     120

actgcagaca agtcaagctg aggaaattgt ggatgatctc ttgtttcttt tgatattcac     180

cacaacagaa gtgaagagtg tgattgcggt tactactgac cacgaagcaa tgcgtttagt     240

agtgaaaaga attactcata ctctggaatc gaaattccgt tggaaaaatt cgctttgtag     300

tgaaaaataa agatgtcaat aaagggtatt gagaatttcc aatggaatta tcagcaatag     360

atgatagaaa gtagcacaga atttggctta atggtatata aaccgtaggg tcctggtaaa     420

attacatggg aaggatcctt aggcagtagg gaaaacttat caggacaatt gagttatatt     480

aacgtattat atattttaat                                                 500


<210> 68
<211> 494
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR1p

<220> 
<223> pLYR1p

<400> 68
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attcctcata ctctggaatc gaaattccgt tggaaaaatt     180

cgctttgtag tgaaaaataa agatgtcaat aaagggtatt gagaatttcc aatggaatta     240

tcagcaatag atgatagaaa gaattcggat gataatgcga ttagtttttt agccttattt     300

ctggggtaat taatcagcga agcgatgatt tttgatctat taacagatat ataaatggaa     360

aagctgcata accactttaa ctaatacttt caacattttc agtttgtatt acttcttatt     420

caaatgtcat aaaagtatca acaaaaaatt gttaatatac ctctatactt taacgtcaag     480

gagaaaaaac tata                                                       494


<210> 69
<211> 494
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR2p

<220> 
<223> pLYR2p

<400> 69
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attctttcta tcatctattg ctgataattc cattggaaat     180

tctcaatacc ctttattgac atctttattt ttcactacaa agcgaatttt tccaacggaa     240

tttcgattcc agagtatgag gaattcggat gataatgcga ttagtttttt agccttattt     300

ctggggtaat taatcagcga agcgatgatt tttgatctat taacagatat ataaatggaa     360

aagctgcata accactttaa ctaatacttt caacattttc agtttgtatt acttcttatt     420

caaatgtcat aaaagtatca acaaaaaatt gttaatatac ctctatactt taacgtcaag     480

gagaaaaaac tata                                                       494


<210> 70
<211> 616
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR3p

<220> 
<223> pLYR3p

<400> 70
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attcctcata ctctggaatc gaaattccgt tggaaaaatt     180

cgctttgtag tgaaaaataa agatgtcaat aaagggtatt gagaatttcc aatggaatta     240

tcagcaatag atgatagaaa gaattcctca tactctggaa tcgaaattcc gttggaaaaa     300

ttcgctttgt agtgaaaaat aaagatgtca ataaagggta ttgagaattt ccaatggaat     360

tatcagcaat agatgataga aagaattcgg atgataatgc gattagtttt ttagccttat     420

ttctggggta attaatcagc gaagcgatga tttttgatct attaacagat atataaatgg     480

aaaagctgca taaccacttt aactaatact ttcaacattt tcagtttgta ttacttctta     540

ttcaaatgtc ataaaagtat caacaaaaaa ttgttaatat acctctatac tttaacgtca     600

aggagaaaaa actata                                                     616


<210> 71
<211> 616
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR4p

<220> 
<223> pLYR4p

<400> 71
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attctttcta tcatctattg ctgataattc cattggaaat     180

tctcaatacc ctttattgac atctttattt ttcactacaa agcgaatttt tccaacggaa     240

tttcgattcc agagtatgag gaattctttc tatcatctat tgctgataat tccattggaa     300

attctcaata ccctttattg acatctttat ttttcactac aaagcgaatt tttccaacgg     360

aatttcgatt ccagagtatg aggaattcgg atgataatgc gattagtttt ttagccttat     420

ttctggggta attaatcagc gaagcgatga tttttgatct attaacagat atataaatgg     480

aaaagctgca taaccacttt aactaatact ttcaacattt tcagtttgta ttacttctta     540

ttcaaatgtc ataaaagtat caacaaaaaa ttgttaatat acctctatac tttaacgtca     600

aggagaaaaa actata                                                     616


<210> 72
<211> 738
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR5p

<220> 
<223> pLYR5p

<400> 72
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attctttcta tcatctattg ctgataattc cattggaaat     180

tctcaatacc ctttattgac atctttattt ttcactacaa agcgaatttt tccaacggaa     240

tttcgattcc agagtatgag gaattctttc tatcatctat tgctgataat tccattggaa     300

attctcaata ccctttattg acatctttat ttttcactac aaagcgaatt tttccaacgg     360

aatttcgatt ccagagtatg aggaattctt tctatcatct attgctgata attccattgg     420

aaattctcaa taccctttat tgacatcttt atttttcact acaaagcgaa tttttccaac     480

ggaatttcga ttccagagta tgaggaattc ggatgataat gcgattagtt ttttagcctt     540

atttctgggg taattaatca gcgaagcgat gatttttgat ctattaacag atatataaat     600

ggaaaagctg cataaccact ttaactaata ctttcaacat tttcagtttg tattacttct     660

tattcaaatg tcataaaagt atcaacaaaa aattgttaat atacctctat actttaacgt     720

caaggagaaa aaactata                                                   738


<210> 73
<211> 1104
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR6p

<220> 
<223> pLYR6p

<400> 73
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attgctcata ctctggaatc gaaattccgt tggaaaaatt     180

cgctttgtag tgaaaaataa agatgtcaat aaagggtatt gagaatttcc aatggaatta     240

tcagcaatag atgatagaaa gaattcctca tactctggaa tcgaaattcc gttggaaaaa     300

ttcgctttgt agtgaaaaat aaagatgtca ataaagggta ttgagaattt ccaatggaat     360

tatcagcaat agatgataga aagaattcct catactctgg aatcgaaatt ccgttggaaa     420

aattcgcttt gtagtgaaaa ataaagatgt caataaaggg tattgagaat ttccaatgga     480

attatcagca atagatgata gaaacaattg ctcatactct ggaatcgaaa ttccgttgga     540

aaaattcgct ttgtagtgaa aaataaagat gtcaataaag ggtattgaga atttccaatg     600

gaattatcag caatagatga tagaaagaat tcctcatact ctggaatcga aattccgttg     660

gaaaaattcg ctttgtagtg aaaaataaag atgtcaataa agggtattga gaatttccaa     720

tggaattatc agcaatagat gatagaaaga attcctcata ctctggaatc gaaattccgt     780

tggaaaaatt cgctttgtag tgaaaaataa agatgtcaat aaagggtatt gagaatttcc     840

aatggaatta tcagcaatag atgatagaaa caattcggat gataatgcga ttagtttttt     900

agccttattt ctggggtaat taatcagcga agcgatgatt tttgatctat taacagatat     960

ataaatggaa aagctgcata accactttaa ctaatacttt caacattttc agtttgtatt    1020

acttcttatt caaatgtcat aaaagtatca acaaaaaatt gttaatatac ctctatactt    1080

taacgtcaag gagaaaaaac tata                                           1104


<210> 74
<211> 1836
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR7p

<220> 
<223> pLYR7p

<400> 74
ttatattgaa ttttcaaaaa ttcttacttt ttttttggat ggacgcaaag aagtttaata      60

atcatattac atggcattac caccatatac atatccatat ctaatcttac ttatatgttg     120

tggaaatgta aagagcccga attgtttcta tcatctattg ctgataattc cattggaaat     180

tctcaatacc ctttattgac atctttattt ttcactacaa agcgaatttt tccaacggaa     240

tttcgattcc agagtatgag gaattctttc tatcatctat tgctgataat tccattggaa     300

attctcaata ccctttattg acatctttat ttttcactac aaagcgaatt tttccaacgg     360

aatttcgatt ccagagtatg aggaattctt tctatcatct attgctgata attccattgg     420

aaattctcaa taccctttat tgacatcttt atttttcact acaaagcgaa tttttccaac     480

ggaatttcga ttccagagta tgagcaattg tttctatcat ctattgctga taattccatt     540

ggaaattctc aatacccttt attgacatct ttatttttca ctacaaagcg aatttttcca     600

acggaatttc gattccagag tatgaggaat tctttctatc atctattgct gataattcca     660

ttggaaattc tcaataccct ttattgacat ctttattttt cactacaaag cgaatttttc     720

caacggaatt tcgattccag agtatgagga attctttcta tcatctattg ctgataattc     780

cattggaaat tctcaatacc ctttattgac atctttattt ttcactacaa agcgaatttt     840

tccaacggaa tttcgattcc agagtatgag caattgtttc tatcatctat tgctgataat     900

tccattggaa attctcaata ccctttattg acatctttat ttttcactac aaagcgaatt     960

tttccaacgg aatttcgatt ccagagtatg aggaattctt tctatcatct attgctgata    1020

attccattgg aaattctcaa taccctttat tgacatcttt atttttcact acaaagcgaa    1080

tttttccaac ggaatttcga ttccagagta tgaggaattc tttctatcat ctattgctga    1140

taattccatt ggaaattctc aatacccttt attgacatct ttatttttca ctacaaagcg    1200

aatttttcca acggaatttc gattccagag tatgagcaat tgtttctatc atctattgct    1260

gataattcca ttggaaattc tcaataccct ttattgacat ctttattttt cactacaaag    1320

cgaatttttc caacggaatt tcgattccag agtatgagga attctttcta tcatctattg    1380

ctgataattc cattggaaat tctcaatacc ctttattgac atctttattt ttcactacaa    1440

agcgaatttt tccaacggaa tttcgattcc agagtatgag gaattctttc tatcatctat    1500

tgctgataat tccattggaa attctcaata ccctttattg acatctttat ttttcactac    1560

aaagcgaatt tttccaacgg aatttcgatt ccagagtatg agcaattcgg atgataatgc    1620

gattagtttt ttagccttat ttctggggta attaatcagc gaagcgatga tttttgatct    1680

attaacagat atataaatgg aaaagctgca taaccacttt aactaatact ttcaacattt    1740

tcagtttgta ttacttctta ttcaaatgtc ataaaagtat caacaaaaaa ttgttaatat    1800

acctctatac tttaacgtca aggagaaaaa actata                              1836


<210> 75
<211> 981
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR8

<220> 
<223> pLYR8

<400> 75
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tgctcatact ctggaatcga aattccgttg gaaaaattcg ctttgtagtg aaaaataaag     420

atgtcaataa agggtattga gaatttccaa tggaattatc agcaatagat gatagaaaga     480

attcctcata ctctggaatc gaaattccgt tggaaaaatt cgctttgtag tgaaaaataa     540

agatgtcaat aaagggtatt gagaatttcc aatggaatta tcagcaatag atgatagaaa     600

gaattcctca tactctggaa tcgaaattcc gttggaaaaa ttcgctttgt agtgaaaaat     660

aaagatgtca ataaagggta ttgagaattt ccaatggaat tatcagcaat agatgataga     720

aacaattcta attaagttag tcaaggcgcc atcctcatga aaactgtgta acataataac     780

cgaagtgtcg aaaaggtggc accttgtcca attgaacacg ctcgatgaaa aaaataagat     840

atatataagg ttaagtaaag cgtctgttag aaaggaagtt tttccttttt cttgctctct     900

tgtcttttca tctactattt ccttcgtgta atacagggtc gtcagataca tagatacaat     960

tctattaccc ccatccatac a                                               981


<210> 76
<211> 981
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR9

<220> 
<223> pLYR9

<400> 76
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tgtttctatc atctattgct gataattcca ttggaaattc tcaataccct ttattgacat     420

ctttattttt cactacaaag cgaatttttc caacggaatt tcgattccag agtatgagga     480

attctttcta tcatctattg ctgataattc cattggaaat tctcaatacc ctttattgac     540

atctttattt ttcactacaa agcgaatttt tccaacggaa tttcgattcc agagtatgag     600

gaattctttc tatcatctat tgctgataat tccattggaa attctcaata ccctttattg     660

acatctttat ttttcactac aaagcgaatt tttccaacgg aatttcgatt ccagagtatg     720

agcaattcta attaagttag tcaaggcgcc atcctcatga aaactgtgta acataataac     780

cgaagtgtcg aaaaggtggc accttgtcca attgaacacg ctcgatgaaa aaaataagat     840

atatataagg ttaagtaaag cgtctgttag aaaggaagtt tttccttttt cttgctctct     900

tgtcttttca tctactattt ccttcgtgta atacagggtc gtcagataca tagatacaat     960

tctattaccc ccatccatac a                                               981


<210> 77
<211> 1225
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR10

<220> 
<223> pLYR10

<400> 77
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tgtttctatc atctattgct gataattcca ttggaaattc tcaataccct ttattgacat     420

ctttattttt cactacaaag cgaatttttc caacggaatt tcgattccag agtatgagga     480

attctttcta tcatctattg ctgataattc cattggaaat tctcaatacc ctttattgac     540

atctttattt ttcactacaa agcgaatttt tccaacggaa tttcgattcc agagtatgag     600

gaattctttc tatcatctat tgctgataat tccattggaa attctcaata ccctttattg     660

acatctttat ttttcactac aaagcgaatt tttccaacgg aatttcgatt ccagagtatg     720

aggaattctt tctatcatct attgctgata attccattgg aaattctcaa taccctttat     780

tgacatcttt atttttcact acaaagcgaa tttttccaac ggaatttcga ttccagagta     840

tgaggaattc tttctatcat ctattgctga taattccatt ggaaattctc aatacccttt     900

attgacatct ttatttttca ctacaaagcg aatttttcca acggaatttc gattccagag     960

tatgagcaat tctaattaag ttagtcaagg cgccatcctc atgaaaactg tgtaacataa    1020

taaccgaagt gtcgaaaagg tggcaccttg tccaattgaa cacgctcgat gaaaaaaata    1080

agatatatat aaggttaagt aaagcgtctg ttagaaagga agtttttcct ttttcttgct    1140

ctcttgtctt ttcatctact atttccttcg tgtaatacag ggtcgtcaga tacatagata    1200

caattctatt acccccatcc ataca                                          1225


<210> 78
<211> 1347
<212> DNA
<213> Artificial Sequence


<220> 
<223> pLYR11

<220> 
<223> pLYR11

<400> 78
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgaat     360

tgctcatact ctggaatcga aattccgttg gaaaaattcg ctttgtagtg aaaaataaag     420

atgtcaataa agggtattga gaatttccaa tggaattatc agcaatagat gatagaaaga     480

attcctcata ctctggaatc gaaattccgt tggaaaaatt cgctttgtag tgaaaaataa     540

agatgtcaat aaagggtatt gagaatttcc aatggaatta tcagcaatag atgatagaaa     600

gaattcctca tactctggaa tcgaaattcc gttggaaaaa ttcgctttgt agtgaaaaat     660

aaagatgtca ataaagggta ttgagaattt ccaatggaat tatcagcaat agatgataga     720

aagaattcct catactctgg aatcgaaatt ccgttggaaa aattcgcttt gtagtgaaaa     780

ataaagatgt caataaaggg tattgagaat ttccaatgga attatcagca atagatgata     840

gaaagaattc ctcatactct ggaatcgaaa ttccgttgga aaaattcgct ttgtagtgaa     900

aaataaagat gtcaataaag ggtattgaga atttccaatg gaattatcag caatagatga     960

tagaaagaat tcctcatact ctggaatcga aattccgttg gaaaaattcg ctttgtagtg    1020

aaaaataaag atgtcaataa agggtattga gaatttccaa tggaattatc agcaatagat    1080

gatagaaaca attctaatta agttagtcaa ggcgccatcc tcatgaaaac tgtgtaacat    1140

aataaccgaa gtgtcgaaaa ggtggcacct tgtccaattg aacacgctcg atgaaaaaaa    1200

taagatatat ataaggttaa gtaaagcgtc tgttagaaag gaagtttttc ctttttcttg    1260

ctctcttgtc ttttcatcta ctatttcctt cgtgtaatac agggtcgtca gatacataga    1320

tacaattcta ttacccccat ccataca                                        1347


<210> 79
<211> 686
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pMET17

<220> 
<223> pMET17

<400> 79
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgagg     360

tcacatgatc gcaaaatggc aaatggcacg tgaagctgtc gatattgggg aactgtggtg     420

gttggcaaat gactaattaa gttagtcaag gcgccatcct catgaaaact gtgtaacata     480

ataaccgaag tgtcgaaaag gtggcacctt gtccaattga acacgctcga tgaaaaaaat     540

aagatatata taaggttaag taaagcgtct gttagaaagg aagtttttcc tttttcttgc     600

tctcttgtct tttcatctac tatttccttc gtgtaataca gggtcgtcag atacatagat     660

acaattctat tacccccatc cataca                                          686


<210> 80
<211> 510
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pMET6

<220> 
<223> pMET6

<400> 80
ccacaggaaa tatttcacgt gacttacaaa cagagtcgta cgtcaggacc ggagtcaggt      60

gaaaaaatgt gggccggtaa agggaaaaaa ccagaaacgg gactactatc gaactcgttt     120

agtcgcgaac gtgcaaaagg ccaatatttt tcgctagagt catcgcagtc atggcagctc     180

tttcgctcta tctcccggtc gcaaaactgt ggtagtcata gctcgttctg ctcaattgag     240

aactgtgaat gtgaatatgg aacaaatgcg atagatgcac taatttaagg gaagctagct     300

agttttccca actgcgaaag aaaaaaagga aagaaaaaaa aattctatat aagtgataga     360

tatttccatc tttactagca ttagtttctc ttttacgtat tcaatatttt tgttaaactc     420

ttcctttatc ataaaaaagc aagcatctaa gagcattgac aacactctaa gaaacaaaat     480

accaatataa tttcaaagta catatcaaaa                                      510


<210> 81
<211> 508
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pMET14

<220> 
<223> pMET14

<400> 81
cctatgcatg tttagagcaa gcgcctttgt gagccctccc ggttacgacg ccttggcaat      60

gtagcagata actctgcact tctagaatca ttccactacg acatttggct catcaccagc     120

tcgcgagaaa tgtaaataag ccaacaacca agaatgcgta acattaaaga atacagttgc     180

tttcatttcg gcgtgatggt acggcaccca cggttcctta cattattctc gaaaaatagc     240

tgcacgcttt tccaggaata aaagaccgtg ccactaattt cacgtgatca atatatttac     300

aagccacctc aaaaaatgtg gcaatggaga agaggatgaa cgactcaata tgacttcaac     360

ttcatgaatt tgtcaaaata tctatataag atgcaaaatt tctatacaac atcagttgcg     420

tatccgttaa tgtcgttcat tttctctctt tgttcgaact tgacatcaag aaaagttgga     480

attatttctc caagcacact gtacacca                                        508


<210> 82
<211> 552
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pMET3

<220> 
<223> pMET3

<400> 82
aacgatatgt acgtagtggt ataaggtgag ggggtccaca gatataacat cgtttaattt      60

agtactaaca gagacttttg tcacaactac atataagtgt acaaatatag tacagatatg     120

acacacttgt agcgccaacg cgcatcctac ggattgctga cagaaaaaaa ggtcacgtga     180

ccagaaaagt cacgtgtaat tttgtaactc accgcattct agcggtccct gtcgtgcaca     240

ctgcactcaa caccataaac cttagcaacc tccaaaggaa atcaccgtat aacaaagcca     300

cagttttaca acttagtctc ttatgaagtt acttaccaat gagaaataga ggctctttct     360

cgacaaatat gaatatggat atatatatat atatatatat atatatatat atatatatgt     420

aaacttggtt cttttttagc ttgtgatctc tagcttgggt ctctctctgt cgtaacagtt     480

gtgatatcgt ttcttaacaa ttgaaaagga actaagaaag tataataata acaagaataa     540

agtataatta ac                                                         552


<210> 83
<211> 363
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pSAM1

<220> 
<223> pSAM1

<400> 83
gaaacggacg taagacggaa atagaatttg aagataaagt tatatatcac tacacacgaa      60

tactttcttt tttttttttc acaggaaaac tgtggtggcg cccttgccta ctagtgcatt     120

tcttttttcg ggttcttgtc tcgacgaaat tttagcctca tcgtagtttt tcactctggt     180

atcgatgaaa aagggaagag taaaaagttt tccgtttagt acttaatggg attggtttgg     240

gacgtatata tcgactggtg ttgtctgtta ttcatcgttg tttttcggtt agcttcgaaa     300

aaaaaataga gtaaaaacca ggaatttacc ctaaaaacaa gaaaaaataa gataaacgaa     360

aat                                                                   363


<210> 84
<211> 500
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pSAM2

<220> 
<223> pSAM2

<400> 84
gagctttgct ctattatata agataaaata tgcactaaaa gtttgcattt ctttacataa      60

ctaaaactaa gacattatgc atagcttacc tgatcaaaaa gtatgtaaac ttgttaacat     120

cttcacatgt gattcatctg gtcgtacttt cttgcggtgc agtgtaatat ttctacccac     180

gtgactataa ttgagcttga aaactgtggc gtttttccac cgatgggtcc acgccagata     240

ttaaccgaag ccaaaatacc gatgaaattt ctgagatagc tcttgtaaac gacgtcaaat     300

cttcatatgc aaggagatct tgatttcttt ttggtagtca tctgtcgtct tgaggcgtat     360

aagaaggagg ttatatctgt cctttctaca aagtattttc gagaatcttg cttctgcccc     420

ttttttcttt ttttaaaagg tttaaaaaac ataactgtct tcaatatatc cagtatttac     480

gacaatatac aaacataatc                                                 500


<210> 85
<211> 913
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pMDH2

<220> 
<223> pMDH2

<400> 85
ccttcgctaa ataataaacc tgaactgtac ttagcgaagc cttcatagca cctacgtaca      60

cgtatatata gacattttac gtaatggaga aactgaggtt tttgttttca ctttttttct     120

ttctttttca ctattgctcg aaccgcctgc gatgagctaa gaaaaaaaag tgaaagaaat     180

catagaaagc aaaaatgaga ttatatagcc cagagccctc ttctggcgcc tgtcccaagg     240

cggaccaaca acaacacttg cccaaaccta agaaaatccc ctcatacttt tccgtttgta     300

tctcctactt tcttacttcc tttttttctt ctttatttgc ttggtttacc attgaagtcc     360

atttttacta cagacaatag ctagtcattc gctatcttcc gtttgtcact ttttttcaaa     420

tttctcatct atatagcgaa gtacggaaaa gatgtcactt gccggcatct cggccttccc     480

cggccaaatg gactcatcat ctacgatacg gcccctttaa tccgcaatta ctttgcccat     540

tcggccgtag ccgttctaaa gccgccgtgc cttgccccca atactcccct aatgatccgg     600

gaagttccgg tttttttcct ttgtttagtg gcattttgtg ttgcccaagg ttgggaaggt     660

ccgatttgac tttaaggaac tacggaaggt atctaaggtt tctaaaaaca atatacacgc     720

gcgtgcgtag atatataaag ataaagattt atcgatatga gataaagatt gctgcatgat     780

tctccttctg attctttttc cctgtatata ttttctcccc ttctgtataa atcgtacagt     840

cagaagtagt ccagaatata gtgctgcaga ctattacaaa agttcaatac aatatcataa     900

aagttatagt aac                                                        913


<210> 86
<211> 998
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pJEN1

<220> 
<223> pJEN1

<400> 86
aatgtgttta taaattattt tttttgctgg tagcaaaatc aactcattgt cttccattca      60

gagtctaatc gaacgttatc gcaatgcttg cacactttta aacaatacga tttagtttaa     120

gtggatggac ccccacgctt agtgttccac aggtttgtcc ccactgtttt tacattccac     180

tgtacatttt tgcaatagaa ggtcattgta tgctaccttg ggcggctaag aatacctgta     240

aaaatttgga gaaattagat tcgtaaagaa tgactcgcaa cgactccaat gatttcttct     300

tttcaccctt tgaacggccg atatccgcgc gggatcctga ccccgcaatt tactccacta     360

gaccggcgtg tttctctttt tccttttcct ggggttagag cccaagagct aatagccgac     420

aaacggactc caaaaaaaaa aggaggcaca ggacaaacgc agcacctgcg tcattcacgc     480

tgaagcggca gcaagcattt tcgatcagct ccaattaaat gaagactatt cgccgtaccg     540

ttcccagatg ggtgcgaaag tcagtgatcg aggaagttat tgagcgcgcg gcttgaaact     600

atttctccat ctcagagccg ccaagcctac cattattctc caccaggaag ttagtttgta     660

agcttctgca caccatccgg acgtccataa ttcttcactt aacggtcttt tgccccccct     720

tctactataa tgcattagaa cgttacctgg tcatttggat ggagatctaa gtaacactta     780

ctatctccta tggtactatc ctttaccaaa aaaaaaaaaa aaaaaaaaaa aaaaaatcag     840

caaagtgaag taccctcttg atgtataaat acattgcaca tcattgttga gaaatagttt     900

tggaagttgt ctagtccttc tcccttagat ctaaaaggaa gaagagtaac agtttcaaaa     960

gtttttcctc aaagagatta aatactgcta ctgaaaat                             998


<210> 87
<211> 450
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pICL1

<220> 
<223> pICL1

<400> 87
ttttgctact cgtcatccga tgagaaaaac tgttcccttt tgccccaggt ttccattcat      60

ccgagcgatc acttatctga cttcgtcact ttttcatttc atccgaaaca atcaaaactg     120

aagccaatca ccacaaaatt aacactcaac gtcatctttc actacccttt acagaagaaa     180

atatccatag tccggactag catcccagta tgtgactcaa tattggtgca aaagagaaaa     240

gcataagtca gtccaaagtc cgcccttaac caggcacatc ggaattcaca aaacgtttct     300

ttattatata aaggagctgc ttcactggca aaattcttat tatttgtctt ggcttgctaa     360

tttcatctta tccttttttt cttttcacac ccaaatacct aacaattgag agaaaactct     420

tagcataaca taacaaaaag tcaacgaaaa                                      450


<210> 88
<211> 598
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pADH2

<220> 
<223> pADH2

<400> 88
tatcttaact gatagtttga tcaaaggggc aaaacgtagg ggcaaacaaa cggaaaaatc      60

gtttctcaaa ttttctgatg ccaagaactc taaccagtct tatctaaaaa ttgccttatg     120

atccgtctct ccggttacag cctgtgtaac tgattaatcc tgcctttcta atcaccattc     180

taatgtttta attaagggat tttgtcttca ttaacggctt tcgctcataa aaatgttatg     240

acgttttgcc cgcaggcggg aaaccatcca cttcacgaga ctgatctcct ctgccggaac     300

accgggcatc tccaacttat aagttggaga aataagagaa tttcagattg agagaatgaa     360

aaaaaaaaaa aaaaaaggca gaggagagca tagaaatggg gttcactttt tggtaaagct     420

atagcatgcc tatcacatat aaatagagtg ccagtagcga cttttttcac actcgaaata     480

ctcttactac tgctctcttg ttgtttttat cacttcttgt ttcttcttgg taaatagaat     540

atcaagctac aaaaagcata caatcaacta tcaactatta actatatcgt aatacaca       598


<210> 89
<211> 793
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> pMLS1

<220> 
<223> pMLS1

<400> 89
tgtctaatgc gaaggtactt ttattttttt cagattcaaa gcaatattat ttagacaatt      60

gatactaagt gagcttaagg aggattaaac aactgtggaa tccttcacaa ggattcaata     120

tttgtttttc ctggttattt tgccatcatt caactttcct cagacgtaaa attcgtgctt     180

agtgatgtct caatattccc gcagggtaat aaaattcaat aactatcact atatacgcaa     240

cagtattacc ctacattgct atcggctcaa tggaaatccc catatcatag cttccattgg     300

gccgatgaag ttagtcgacg gatagaagcg gttgtcccct ttcccggcga gccggcagtc     360

gggccgaggt tcggataaat tttgtattgt gttttgattc tgtcatgagt attacttatg     420

ttctctttag gtaaccccag gttaatcaat cacagtttca taccggctag tattcaaatt     480

atgacttttc ttctgcagtg tcagccttac gacgattatc tatgagcttt gaatatagtt     540

tgccgtgatt cgtatcttta attggataat aaaatgcgaa ggatcgatga cccttattat     600

tatttttcta cactggctac cgatttaact catcttcttg aaagtatata agtaacagta     660

aaatataccg tacttctgct aatgttattt gtcccttatt tttcttttct tgtcttatgc     720

tatagtacct aagaataacg actattgttt tgaactaaac aaagtagtaa aagcacataa     780

aagaattaag aaa                                                        793


<210> 90
<211> 300
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tTDH2

<220> 
<223> tTDH2

<400> 90
atttaactcc ttaagttact ttaatgattt agtttttatt attaataatt catgctcatg     60

acatctcata tacacgttta taaaacttaa atagattgaa aatgtattaa agattcctca    120

gggattcgat ttttttggaa gtttttgttt ttttttcctt gagatgctgt agtatttggg    180

aacaattata caatcgaaag atatatgctt acattcgacc gttttagccg tgatcattat    240

cctatagtaa cataacctga agcataactg acactactat catcaatact tgtcacatga    300


<210> 91
<211> 300
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tCYC1

<220> 
<223> tCYC1

<400> 91
acaggcccct tttcctttgt cgatatcatg taattagtta tgtcacgctt acattcacgc     60

cctcctccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc    120

cctatttatt ttttttaata gttatgttag tattaagaac gttatttata tttcaaattt    180

ttcttttttt tctgtacaaa cgcgtgtacg catgtaacat tatactgaaa accttgcttg    240

agaaggtttt gggacgctcg aaggctttaa tttgcaagct tcgcagttta cactctcatc    300


<210> 92
<211> 300
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tTDH3

<220> 
<223> tTDH3

<400> 92
gtgaatttac tttaaatctt gcatttaaat aaattttctt tttatagctt tatgacttag     60

tttcaattta tatactattt taatgacatt ttcgattcat tgattgaaag ctttgtgttt    120

tttcttgatg cgctattgca ttgttcttgt ctttttcgcc acatgtaata tctgtagtag    180

atacctgata cattgtggat gctgagtgaa attttagtta ataatggagg cgctcttaat    240

aattttgggg atattggctt ttttttttaa agtttacaaa tgaatttttt ccgccaggat    300


<210> 93
<211> 354
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tADH1

<220> 
<223> tADH1

<400> 93
actagttcta gagcggccgc caccgcggtg ggcgaatttc ttatgattta tgatttttat      60

tattaaataa gttataaaaa aaataagtgt atacaaattt taaagtgact cttaggtttt     120

aaaacgaaaa ttcttattct tgagtaactc tttcctgtag gtcaggttgc tttctcaggt     180

atagcatgag gtcgctctta ttgaccacac ctctaccggc atgccgagca aatgcctgca     240

aatcgctccc catttcaccc aattgtagat atgctaactc cagcaatgag ttgatgaatc     300

tcggtgtgta ttttatgtcc tcagaggaca acacctgttg taatcgttct tcca           354


<210> 94
<211> 301
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tADH2

<220> 
<223> tADH2

<400> 94
gcggatctct tatgtcttta cgatttatag ttttcattat caagtatgcc tatattagta     60

tatagcatct ttagatgaca gtgttcgaag tttcacgaat aaaagataat attctacttt    120

ttgctcccac cgcgtttgct agcacgagtg aacaccatcc ctcgcctgtg agttgtaccc    180

attcctctaa actgtagaca tggtagcttc agcagtgttc gttatgtacg gcatcctcca    240

acaaacagtc ggttatagtt tgtcctgctc ctctgaatcg tctccctcga tatttctcat    300

t                                                                    301


<210> 95
<211> 299
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tTPI1

<220> 
<223> tTPI1

<400> 95
gattaatata attatataaa aatattatct tcttttcttt atatctagtg ttatgtaaaa     60

taaattgatg actacggaaa gcttttttat attgtttctt tttcattctg agccacttaa    120

atttcgtgaa tgttcttgta agggacggta gatttacaag tgatacaaca aaaagcaagg    180

cgctttttct aataaaaaga agaaaagcat ttaacaattg aacacctcta tatcaacgaa    240

gaatattact ttgtctctaa atccttgtaa aatgtgtacg atctctatat gggttactc     299


<210> 96
<211> 299
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tMET17

<220> 
<223> tMET17

<400> 96
gtgtgcgtaa tgagttgtaa aattatgtat aaacctactt tctctcacaa gtactatact     60

tttataaaac gaactttatt gaaatgaata tccttttttt cccttgttac atgtcgtgac    120

tcgtactttg aacctaaatt gttctaacat caaagaacag tgttaattcg cagtcgagaa    180

gaaaaatatg gtgaacaaga ctcatctact tcatgagact actttacgcc tcctataaag    240

ctgtcacact ggataaattt attgtaggac caagttacaa aagaggatga tggaggttt     299


<210> 97
<211> 305
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tENO2

<220> 
<223> tENO2

<400> 97
ggatcctaaa gtgcttttaa ctaagaatta ttagtctttt ctgcttattt tttcatcata     60

gtttagaaca ctttatatta acgaatagtt tatgaatcta tttaggttta aaaattgata    120

cagttttata agttactttt tcaaagactc gtgctgtcta ttgcataatg cactggaagg    180

ggaaaaaaaa ggtgcacacg cgtggctttt tcttgaattt gcagtttgaa aaataactac    240

atggatgata agaaaacatg gagtacagtc actttgagaa ccttcaatca gctggtaacg    300

tcttc                                                                305


<210> 98
<211> 300
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tMET3

<220> 
<223> tMET3

<400> 98
tcgtcataaa atgctcccat ctcaaaagta gggcaaaatt catgatcgac cgcgcaaaat     60

aaatagattt gcaaataagt tttgtatgta catttattaa tatatataat atatcaaaag    120

aaaaaaatca aaaaaaaaaa aaaaaaaaaa ttgcactctt attcagtcat caattacaaa    180

acctagagat agcgatggtg catattcaat aaaaaactcc ttatactgtc gagaaagctt    240

attattggta cttctcgaag atactaaaaa aggttaattt ttggagacgg aggcaatagc    300


<210> 99
<211> 301
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tPGK1

<220> 
<223> tPGK1

<400> 99
attgaattga attgaaatcg atagatcaat ttttttcttt tctctttccc catcctttac     60

gctaaaataa tagtttattt tattttttga atatttttta tttatatacg tatatataga    120

ctattattta tcttttaatg attattaaga tttttattaa aaaaaaattc gctcctcttt    180

taatgccttt atgcagtttt tttttcccat tcgatatttc tatgttcggg ttcagcgtat    240

tttaagttta ataactcgaa aattctgcgt tcgttaaagc tttcgagaag gatattattt    300

a                                                                    301


<210> 100
<211> 300
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tDIT1

<220> 
<223> tDIT1

<400> 100
taaagtaaga gcgctacatt ggtctacctt tttgttcttt tacttaaaca ttagttagtt     60

cgttttcttt ttctcatttt tttatgtttc ccccccaaag ttctgatttt ataatatttt    120

atttcacaca attccattta acagaggggg aatagattct ttagcttaga aaattagtga    180

tcaatatata tttgcctttc ttttcatctt ttcagtgata ttaatggttt cgagacactg    240

caatggccct agttgtctaa gaggatagat gttactgtca aagatgatat tttgaatttc    300


<210> 101
<211> 300
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tRPL3

<220> 
<223> tRPL3

<400> 101
gaagttttgt tagaaaataa atcatttttt aattgagcat tcttattcct attttattta     60

aatagtttta tgtattgtta gctacataca acagtttaaa tcaaattttc tttttcccaa    120

gtccaaaatg gaggtttatt ttgatgaccc gcatgcgatt atgttttgaa agtataagac    180

tacatacatg tacatatatt taaacatgta aacccgtcca ttatattgct tactttcttc    240

ttttttgccg ttttgacttg gacctctggt ttgctatttc cttacaatct ttgctacaat    300


<210> 102
<211> 300
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tRPL41B

<220> 
<223> tRPL41B

<400> 102
gcggattgag agcaaatcgt taagttcagg tcaagtaaaa attgatttcg aaaactaatt     60

tctcttatac aatcctttga ttggaccgtc atcctttcga atataagatt ttgttaagaa    120

tattttagac agagatctac tttatattta atatctagat attacataat ttcctctcta    180

ataaaatatc attaataaaa taaaaatgaa gcgatttgat tttgtgttgt caacttagtt    240

tgccgctatg cctcttgggt aatgctatta ttgaatcgaa gggctttatt atattaccct    300


<210> 103
<211> 300
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tRPL15A

<220> 
<223> tRPL15A

<400> 103
gctggttgat ggaaaatata attttattgg gcaaactttt gtttatctga tgtgttttat     60

actattatct ttttaattaa tgattctata tacaaacctg tatatttttt ctttaaccaa    120

tttttttttt tatagaccta gagctgtact tttattctgc tatcaagcaa acccctaccc    180

cctcttctca atcctcccct caggcagaac ttatctacct gtatcaagga gcggacgagg    240

gagtcctaat tgttctacgt ataccaatgc tagcagctta cataggtggt ggcactacca    300


<210> 104
<211> 300
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> tIDP1

<220> 
<223> tIDP1

<400> 104
tcgaatttac gtagcccaat ctaccacttt tttttttcat tttttaaagt gttatactta     60

gttatgctct aggataatga actacttttt tttttttttt tttactgtta tcataaatat    120

atatacctta ttgttgtttg caaccgtcgg ttaattcctt atcaaggttc cccaagttcg    180

gatcattacc atcaatttcc aacattttca tgagttcttc ttcttcatta ccgtgtttta    240

gggggctgtt cgcacttcta atagggctat caccaagctg ttctaattcg tccaaaagtt    300


<210> 105
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence of the enzymes able to catalyze the
      decarboxylation of oxaloacetate into malonic semi-aldehyde

<220> 
<221> VARIANT
<222> 19
<223> Xaa in position 19 is selected from the group consisting of
      threonine and isoleucine

<220> 
<221> VARIANT
<222> 109
<223> Xaa in position 109 is selected from the group consisting of
      leucine, lysine, arginine and valine

<220> 
<221> VARIANT
<222> 110
<223> Xaa in position 110 is selected from the group consisting of
      leucine and lysine

<220> 
<221> VARIANT
<222> 180
<223> Xaa in position 180 is selected from the group consisting of
      serine and threonine

<220> 
<221> VARIANT
<222> 204
<223> Xaa in position 204 is selected from the group consisting of
      alanine and valine

<220> 
<221> VARIANT
<222> 281
<223> Xaa in position 281 is selected from the group consisting of
      histidine and arginine

<220> 
<221> VARIANT
<222> 282
<223> Xaa in position 282 is selected from the group consisting of
      glutamine and arginine

<220> 
<221> VARIANT
<222> 369
<223> Xaa in position 369 is selected from the group consisting of
      asparagine and aspartic acid

<220> 
<221> VARIANT
<222> 377
<223> Xaa in position 377 is selected from the group consisting of
      threonine and serine

<220> 
<221> VARIANT
<222> 388
<223> Xaa in position 388 is selected from the group consisting of
      asparagine and aspartic acid

<220> 
<221> VARIANT
<222> 397
<223> Xaa in position 397 is selected from the group consisting of
      phenylalanine, asparagine, alanine, isoleucine, valine, leucine,
      tryptophan and arginine

<220> 
<221> VARIANT
<222> 398
<223> Xaa in position 398 is selected from the group consisting of
      cysteine and arginine

<220> 
<221> VARIANT
<222> 403
<223> Xaa in position 403 is selected from the group consisting of
      leucine, asparagine, alanine, valine and serine

<220> 
<221> VARIANT
<222> 419
<223> Xaa in position 419 is selected from the group consisting of
      glutamic acid and glycine

<220> 
<221> VARIANT
<222> 446
<223> Xaa in position 446 is selected from the group consisting of
      isoleucine and valine

<220> 
<221> VARIANT
<222> 460
<223> Xaa in position 460 is selected from the group consisting of
      alanine, leucine, threonine, glycine and asparagine

<220> 
<221> VARIANT
<222> 464
<223> Xaa in position 464 is selected from the group consisting of
      phenylalanine and serine

<220> 
<221> VARIANT
<222> 469
<223> Xaa in position 469 is selected from the group consisting of
      glutamic acid and glycine

<400> 105
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Xaa Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Xaa Xaa Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Xaa Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Xaa Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Xaa Xaa Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Xaa Ala Ile Tyr Leu Asn Glu Ser Xaa Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Xaa Met Arg Asn Pro Gly Ser Tyr Tyr Xaa Xaa Ala Ala 
385                 390                 395                 400 
Gly Gly Xaa Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Xaa Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Xaa Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Xaa Leu Arg Trp Xaa 
    450                 455                 460                 
Ala Gly Val Leu Xaa Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 106
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°6

<400> 106
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Leu Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Val Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 107
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°7

<400> 107
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Ile Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Arg Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asp Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Gly Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Leu Leu Arg Trp Ser 
    450                 455                 460                 
Ala Gly Val Leu Gly Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 108
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°8

<400> 108
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Arg Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Gly Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 109
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°9

<400> 109
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 110
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°10

<400> 110
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Ala Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 111
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°11

<400> 111
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Leu Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 112
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°12

<400> 112
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Arg Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 113
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°13

<400> 113
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Arg Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 114
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°14

<400> 114
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 115
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°15

<400> 115
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Leu Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 116
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°116

<400> 116
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Leu Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Val Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Leu Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 117
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°17

<400> 117
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Leu Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Val Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Gly Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 118
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°18

<400> 118
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Leu Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Val Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Ser 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 119
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°19

<400> 119
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Leu Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Gly Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Val Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Ser 
    450                 455                 460                 
Ala Gly Val Leu Gly Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 120
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°20

<400> 120
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Leu Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Gly Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Ser 
    450                 455                 460                 
Ala Gly Val Leu Gly Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 121
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°21

<400> 121
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Ile Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asp Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Gly Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Leu Leu Arg Trp Ser 
    450                 455                 460                 
Ala Gly Val Leu Gly Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 122
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°22

<400> 122
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Arg Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Asn Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Leu Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 123
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°23

<400> 123
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Arg Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Trp Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 124
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°24

<400> 124
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Arg Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Arg Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Val Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 125
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°25

<400> 125
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Arg Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Trp Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Asn Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 126
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°26

<400> 126
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Thr Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Val Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Phe Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 127
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°27

<400> 127
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Ala Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 128
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°28

<400> 128
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Leu Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 129
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°29

<400> 129
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Arg Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Val Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Val Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Ala Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 130
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°30

<400> 130
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Arg Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Val Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Val Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Gly Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 131
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°31

<400> 131
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Trp Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Ser Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Val Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Asn Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 132
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°32

<400> 132
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Arg Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Trp Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Leu Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 133
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°33

<400> 133
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr Arg Gln Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Arg Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Leu Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 134
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°34

<400> 134
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Trp Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 135
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°35

<400> 135
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asn Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Arg Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Leu Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Ile Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 136
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°36

<400> 136
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Arg Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Val Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Val Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



<210> 137
<211> 528
<212> PRT
<213> Artificial Sequence


<220> 
<223> Enzyme N°37

<400> 137
Met Ala Ser Val His Gly Thr Thr Tyr Glu Leu Leu Arg Arg Gln Gly 
1               5                   10                  15      
Ile Asp Thr Val Phe Gly Asn Pro Gly Ser Asn Glu Leu Pro Phe Leu 
            20                  25                  30          
Lys Asp Phe Pro Glu Asp Phe Arg Tyr Ile Leu Ala Leu Gln Glu Ala 
        35                  40                  45              
Cys Val Val Gly Ile Ala Asp Gly Tyr Ala Gln Ala Ser Arg Lys Pro 
    50                  55                  60                  
Ala Phe Ile Asn Leu His Ser Ala Ala Gly Thr Gly Asn Ala Met Gly 
65                  70                  75                  80  
Ala Leu Ser Asn Ala Trp Asn Ser His Ser Pro Leu Ile Val Thr Ala 
                85                  90                  95      
Gly Gln Gln Thr Arg Ala Met Ile Gly Val Glu Ala Arg Leu Thr Asn 
            100                 105                 110         
Val Asp Ala Ala Asn Leu Pro Arg Pro Leu Val Lys Trp Ser Tyr Glu 
        115                 120                 125             
Pro Ala Ser Ala Ala Glu Val Pro His Ala Met Ser Arg Ala Ile His 
    130                 135                 140                 
Met Ala Ser Met Ala Pro Gln Gly Pro Val Tyr Leu Ser Val Pro Tyr 
145                 150                 155                 160 
Asp Asp Trp Asp Lys Asp Ala Asp Pro Gln Ser His His Leu Phe Asp 
                165                 170                 175     
Arg His Val Ser Ser Ser Val Arg Leu Asn Asp Gln Asp Leu Asp Ile 
            180                 185                 190         
Leu Val Lys Ala Leu Asn Ser Ala Ser Asn Pro Ala Ile Val Leu Gly 
        195                 200                 205             
Pro Asp Val Asp Ala Ala Asn Ala Asn Ala Asp Cys Val Met Leu Ala 
    210                 215                 220                 
Glu Arg Leu Lys Ala Pro Val Trp Val Ala Pro Ser Ala Pro Arg Cys 
225                 230                 235                 240 
Pro Phe Pro Thr Arg His Pro Cys Phe Arg Gly Leu Met Pro Ala Gly 
                245                 250                 255     
Ile Ala Ala Ile Ser Gln Leu Leu Glu Gly His Asp Val Val Leu Val 
            260                 265                 270         
Ile Gly Ala Pro Val Phe Arg Tyr His Arg Tyr Asp Pro Gly Gln Tyr 
        275                 280                 285             
Leu Lys Pro Gly Thr Arg Leu Ile Ser Val Thr Cys Asp Pro Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Pro Met Gly Asp Ala Ile Val Ala Asp Ile Gly Ala 
305                 310                 315                 320 
Met Ala Ser Ala Leu Ala Asn Leu Val Glu Glu Ser Ser Arg Gln Leu 
                325                 330                 335     
Pro Thr Ala Ala Pro Glu Pro Ala Lys Val Asp Gln Asp Ala Gly Arg 
            340                 345                 350         
Leu His Pro Glu Thr Val Phe Asp Thr Leu Asn Asp Met Ala Pro Glu 
        355                 360                 365             
Asp Ala Ile Tyr Leu Asn Glu Ser Thr Ser Thr Thr Ala Gln Met Trp 
    370                 375                 380                 
Gln Arg Leu Asn Met Arg Asn Pro Gly Ser Tyr Tyr Trp Cys Ala Ala 
385                 390                 395                 400 
Gly Gly Ser Gly Phe Ala Leu Pro Ala Ala Ile Gly Val Gln Leu Ala 
                405                 410                 415     
Glu Pro Glu Arg Gln Val Ile Ala Val Ile Gly Asp Gly Ser Ala Asn 
            420                 425                 430         
Tyr Ser Ile Ser Ala Leu Trp Thr Ala Ala Gln Tyr Asn Val Pro Thr 
        435                 440                 445             
Ile Phe Val Ile Met Asn Asn Gly Thr Tyr Gly Thr Leu Arg Trp Phe 
    450                 455                 460                 
Ala Gly Val Leu Glu Ala Glu Asn Val Pro Gly Leu Asp Val Pro Gly 
465                 470                 475                 480 
Ile Asp Phe Arg Ala Leu Ala Lys Gly Tyr Gly Val Gln Ala Leu Lys 
                485                 490                 495     
Ala Asp Asn Leu Glu Gln Leu Lys Gly Ser Leu Gln Glu Ala Leu Ser 
            500                 505                 510         
Ala Lys Gly Pro Val Leu Ile Glu Val Ser Thr Val Ser Pro Val Lys 
        515                 520                 525             



