               SEQUENCE LISTING

<110> Alligator Bioscience AB

<120> Novel Polypeptides

<130> ALLBL/P70791PC

<140> PCT/EP2019/085786
<141> 2019-12-17

<150> GB 1910016.3
<151> 2019-07-12

<150> GB 1905467.5
<151> 2019-04-17

<150> GB 1820556.7
<151> 2018-12-17

<160> 195

<170> BiSSAP 1.3.6

<210> 1
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 1
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Arg Asn Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 2
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 2
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60

attacctgcc gcgcgagcca gagcattagc agctatctga actggtatca gcagaaaccg     120

ggcaaagcgc cgaaactgct gatttatgcg gcgagcagcc tgcagagcgg cgtgccgagc     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg     240

gaagattttg cgacctatta ttgccagcag tatggccgca acccgccgac ctttggccag     300

ggcaccaaac tggaaattaa a                                               321


<210> 3
<211> 117
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 3
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Gly Ser Tyr Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Val Asn Phe Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 4
<211> 351
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 4
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg      60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg     120

ccgggcaaag gcctggaatg ggtgagcggc attggcagct atggcggcgg cacctattat     180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgctatgtg     300

aactttggca tggattattg gggccagggc accctggtga ccgtgagcag c              351


<210> 5
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 5
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp His Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Ala Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 6
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 6
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcatgtgacc      60

attacctgcc gcgcgagcca gagcattagc agctatctga actggtatca gcagaaaccg     120

ggcaaagcgc cgaaactgct gatttatgcg gcgagcagcc tgcagagcgg cgtgccgagc     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg     240

gaagattttg cgacctatta ttgccagcag tatggcagcg cgccgccgac ctttggccag     300

ggcaccaaac tggaaattaa a                                               321


<210> 7
<211> 117
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 7
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Gly Gly Ser Ser Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Tyr Ser Tyr His Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 8
<211> 351
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 8
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg      60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg     120

ccgggcaaag gcctggaatg ggtgagcggc attggcggca gcagcagcta taccagctat     180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgctattat     300

agctatcata tggattattg gggccagggc accctggtga ccgtgagcag c              351


<210> 9
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 10
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 10
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60

attacctgcc gcgcgagcca gagcattagc agctatctga actggtatca gcagaaaccg     120

ggcaaagcgc cgaaactgct gatttatgcg gcgagcagcc tgcagagcgg cgtgccgagc     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg     240

gaagattttg cgacctatta ttgccagcag agctatagca ccccgtatac ctttggccag     300

ggcaccaaac tggaaattaa a                                               321


<210> 11
<211> 119
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 11
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Pro Val Tyr Ser Ser Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 12
<211> 357
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 12
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg      60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg     120

ccgggcaaag gcctggaatg ggtgagcgcg attagcggca gcggcggcag cacctattat     180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcggcccg     300

gtgtatagca gcgtgtttga ttattggggc cagggcaccc tggtgaccgt gagcagc        357


<210> 13
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 13
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Val Tyr Pro Phe 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 14
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 14
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60

attacctgcc gcgcgagcca gagcattagc agctatctga actggtatca gcagaaaccg     120

ggcaaagcgc cgaaactgct gatttatgcg gcgagcagcc tgcagagcgg cgtgccgagc     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg     240

gaagattttg cgacctatta ttgccagcag tatggcgtgt atccgtttac ctttggccag     300

ggcaccaaac tggaaattaa a                                               321


<210> 15
<211> 116
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 15
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Val Trp Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 16
<211> 348
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 16
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg      60

agctgcgcgg cgagcggctt tacctttagc agctatgcga tgagctgggt gcgccaggcg     120

ccgggcaaag gcctggaatg ggtgagcgcg attagcggca gcggcggcag cacctattat     180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccgcgtg     300

tggggctttg attattgggg ccagggcacc ctggtgaccg tgagcagc                  348


<210> 17
<211> 112
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 17
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asn Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Lys Ser 
                85                  90                  95      
Ile Ser Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210> 18
<211> 336
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 18
cagagcgtgc tgacccagcc gccgagcgcg agcggcaccc cgggccagcg cgtgaccatt      60

agctgcaccg gcagcagcag caacattggc gcgggctata acgtgtattg gtatcagcag     120

ctgccgggca ccgcgccgaa actgctgatt tatggcaaca ttaaccgccc gagcggcgtg     180

ccggatcgct ttagcggcag caaaagcggc accagcgcga gcctggcgat tagcggcctg     240

cgcagcgaag atgaagcgga ttattattgc gcggcgtggg ataaaagcat tagcggcctg     300

gtgtttggcg gcggcaccaa actgaccgtg ctgggg                               336


<210> 19
<211> 119
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 19
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Ser Tyr Ile Ser Gly Gly Ser Ser Tyr Ile Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Ala Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ile Leu Arg Gly Gly Ser Gly Met Asp Leu Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 20
<211> 357
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 20
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg      60

agctgcgcgg cgagcggctt tacctttagc acctatggca tgcattgggt gcgccaggcg     120

ccgggcaaag gcctggaatg gctgagctat attagcggcg gcagcagcta tattttttat     180

gcggatagcg tgcgcggccg ctttaccatt agccgcgata acagcgaaaa cgcgctgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcattctg     300

cgcggcggca gcggcatgga tctgtggggc cagggcaccc tggtgaccgt gagcagc        357


<210> 21
<211> 108
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Arg 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Cys Thr Gly Tyr Gly Ile Ser 
                85                  90                  95      
Trp Pro Ile Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 22
<211> 324
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 22
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60

attaaatgcc aggcgagcca gagcattagc agccgcctgg cgtggtatca gcagaaaccg     120

ggcaaaccgc cgaaactgct gatttatcgc gcgagcaccc tggcgagcgg cgtgccgagc     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg     240

gaagatgtgg cgacctatta ttgccagtgc accggctatg gcattagctg gccgattggc     300

ggcggcacca aagtggaaat taaa                                            324


<210> 23
<211> 120
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 23
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Thr 
            20                  25                  30          
Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ala Cys Ile Tyr Thr Gly Asp Gly Thr Asn Tyr Ser Ala Ser Trp Ala 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Pro Asp Ile Thr Tyr Gly Phe Ala Ile Asn Phe Trp Gly Pro 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 24
<211> 360
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 24
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg      60

agctgcgcgg cgagcggctt tagctttagc agcacctatg tgtgctgggt gcgccaggcg     120

ccgggcaaag gcctggaatg gattgcgtgc atttataccg gcgatggcac caactatagc     180

gcgagctggg cgaaaggccg ctttaccatt agcaaagata gcagcaaaaa caccgtgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt atttttgcgc gcgcccggat     300

attacctatg gctttgcgat taacttttgg ggcccgggca ccctggtgac cgtgagcagc     360


<210> 25
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 25
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              
Tyr Thr Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ile Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 26
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 26
gatattcaga tgacccagag cccgagcagc gtgagcgcga gcgtgggcga tcgcgtgacc      60

attacctgcc gcgcgagcca gggcatttat agctggctgg cgtggtatca gcagaaaccg     120

ggcaaagcgc cgaacctgct gatttatacc gcgagcaccc tgcagagcgg cgtgccgagc     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg     240

gaagattttg cgacctatta ttgccagcag gcgaacattt ttccgctgac ctttggcggc     300

ggcaccaaag tggaaattaa a                                               321


<210> 27
<211> 126
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 27
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Pro Asp Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
            100                 105                 110         
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210> 28
<211> 378
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 28
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg      60

agctgcaaag cgagcggcta tacctttacc ggctattata tgcattgggt gcgccaggcg     120

ccgggccagg gcctggaatg gatgggctgg attaacccgg atagcggcgg caccaactat     180

gcgcagaaat ttcagggccg cgtgaccatg acccgcgata ccagcattag caccgcgtat     240

atggaactga accgcctgcg cagcgatgat accgcggtgt attattgcgc gcgcgatcag     300

ccgctgggct attgcaccaa cggcgtgtgc agctattttg attattgggg ccagggcacc     360

ctggtgaccg tgagcagc                                                   378


<210> 29
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 29
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 30
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 30
gaaattgtgc tgacccagag cccggcgacc ctgagcctga gcccgggcga acgcgcgacc      60

ctgagctgcc gcgcgagcca gagcgtgagc agctatctgg cgtggtatca gcagaaaccg     120

ggccaggcgc cgcgcctgct gatttatgat gcgagcaacc gcgcgaccgg cattccggcg     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctggaaccg     240

gaagattttg cggtgtatta ttgccagcag cgccgcaact ggccgctgac ctttggcggc     300

ggcaccaaag tggaaattaa a                                               321


<210> 31
<211> 118
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 31
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Leu Trp Gly Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 32
<211> 354
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 32
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg      60

agctgcgcgg cgagcggctt tacctttagc aactatggca tgtattgggt gcgccaggcg     120

ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa caaatattat     180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcgatctg     300

tggggctggt attttgatta ttggggccag ggcaccctgg tgaccgtgag cagc           354


<210> 33
<211> 113
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 33
Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 34
<211> 339
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 34
gaactggtga tgacccagag cccgagcagc ctgaccgtga ccgcgggcga aaaagtgacc      60

atgagctgca aaagcagcca gagcctgctg aacagcggca accagaaaaa ctatctgacc     120

tggtatcagc agaaaccggg ccagccgccg aaactgctga tttattgggc gagcacccgc     180

gaaagcggcg tgccggatcg ctttaccggc agcggcagcg gcaccgattt taccctgacc     240

attagcagcg tgcaggcgga agatctggcg gtgtattatt gccagaacga ttatagctat     300

ccgctgacct ttggcgcggg caccaaactg gaaattaaa                            339


<210> 35
<211> 120
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 35
Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      
Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
            20                  25                  30          
Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
    50                  55                  60                  
Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  
Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      
Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210> 36
<211> 360
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 36
gaagtgcagc tgctggaaca gagcggcgcg gaactggtgc gcccgggcac cagcgtgaaa      60

attagctgca aagcgagcgg ctatgcgttt accaactatt ggctgggctg ggtgaaacag     120

cgcccgggcc atggcctgga atggattggc gatatttttc cgggcagcgg caacattcat     180

tataacgaaa aatttaaagg caaagcgacc ctgaccgcgg ataaaagcag cagcaccgcg     240

tatatgcagc tgagcagcct gacctttgaa gatagcgcgg tgtatttttg cgcgcgcctg     300

cgcaactggg atgaaccgat ggattattgg ggccagggca ccaccgtgac cgtgagcagc     360


<210> 37
<211> 732
<212> DNA
<213> Synthetic


<220> 
<223> full DNA seqence

<400> 37
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgcggttac     300

gcttctttcg ttggtggtta ctttgactat tggggccagg gaaccctggt caccgtctcc     360

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcgga catccagatg     420

acccagtctc catcctccct gagcgcatct gtaggagacc gcgtcaccat cacttgccgg     480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct     540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcacg tttcagtggc     600

agtggaagcg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca     660

acttattact gtcaacagcc gggttcttct tctccgtaca cttttggcca ggggaccaag     720

ctggagatca aa                                                         732


<210> 38
<211> 244
<212> PRT
<213> Synthetic


<220> 
<223> Full amino acid sequence

<400> 38
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Tyr Ala Ser Phe Val Gly Gly Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 
Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 
Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     
Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 
Gln Gln Pro Gly Ser Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 
Leu Glu Ile Lys 
                

<210> 39
<211> 108
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 39
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Gly Ser Ser Ser Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210> 40
<211> 121
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 40
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Tyr Ala Ser Phe Val Gly Gly Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 41
<211> 723
<212> DNA
<213> Synthetic


<220> 
<223> Full DNA sequence

<400> 41
gaggtgcagc tgttggagag cgggggaggc ttggtacagc ctggggggtc cctgcgcctc      60

tcctgtgcag ccagcggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactat     180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat     240

ctgcaaatga acagcctgcg tgccgaggac acggctgtat attattgtgc gcgctctggt     300

ggttactctg gtgaccattt tgactattgg ggccagggaa ccctggtcac cgtctcctca     360

ggtggaggcg gttcaggcgg aggtggatcc ggcggtggcg gatcggacat ccagatgacc     420

cagtctccat cctccctgag cgcatctgta ggagaccgcg tcaccatcac ttgccgggca     480

agtcagagca ttagcagcta tttaaattgg tatcagcaga aaccagggaa agcccctaag     540

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcacgttt cagtggcagt     600

ggaagcggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact     660

tattactgtc aacagtctta caacctgttc acttttggcc aggggaccaa gctggagatc     720

aaa                                                                   723


<210> 42
<211> 241
<212> PRT
<213> Synthetic


<220> 
<223> Full amino acid sequence

<400> 42
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Ser Gly Asp His Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 
Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     
Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 
Gln Ser Tyr Asn Leu Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 
Lys 
    

<210> 43
<211> 106
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 43
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Leu Phe Thr 
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 44
<211> 120
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 44
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Gly Gly Tyr Ser Gly Asp His Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 45
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 45
Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Ile Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 46
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 46
gaactgcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60

attacctgcc gcaccagcca gagcattagc agctatctga actggtatca gcagaaaccg     120

ggccagccgc cgaaactgct gatttattgg gcgagcaccc gcgaaagcgg cgtgccggat     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg     240

gaagatagcg cgacctatta ttgccagcag agctatgata ttccgtatac ctttggccag     300

ggcaccaaac tggaaattaa a                                               321


<210> 47
<211> 127
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 47
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Met Gly Trp Gly Ser Gly Trp Arg Pro Tyr Tyr Tyr Tyr 
            100                 105                 110         
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         

<210> 48
<211> 381
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 48
gaagtgcagc tgctggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg      60

agctgcgcgg cgagcggctt tacctttagc agctatggca tgcattgggt gcgccaggcg     120

ccgggcaaag gcctggaatg ggtggcggtg attagctatg atggcagcaa caaatattat     180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gaaagatatg     300

ggctggggca gcggctggcg cccgtattat tattatggca tggatgtgtg gggccagggc     360

accaccgtga ccgtgagcag c                                               381


<210> 49
<211> 112
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 49
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         



<210> 50
<211> 336
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 50
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60

attacctgcc gcagcaccaa aagcctgctg catagcaacg gcattaccta tctgtattgg     120

tatcagcaga aaccgggcaa agcgccgaaa ctgctgattt atcagatgag caacctggcg     180

agcggcgtgc cgagccgctt tagcagcagc ggcagcggca ccgattttac cctgaccatt     240

agcagcctgc agccggaaga ttttgcgacc tattattgcg cgcagaacct ggaaattccg     300

cgcacctttg gccagggcac caaagtggaa ctgaaa                               336


<210> 51
<211> 116
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 51
Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Ala Ser Ala Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Leu 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 52
<211> 348
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 52
gaagtgcagc tggtgcagag cggcccgggc ctggtgcagc cgggcggcag cgtgcgcatt      60

agctgcgcgg cgagcggcta tacctttacc aactatggca tgaactgggt gaaacaggcg     120

ccgggcaaag gcctggaatg gatgggctgg attaacacct ataccggcga aagcacctat     180

gcggatagct ttaaaggccg ctttaccttt agcctggata ccagcgcgag cgcggcgtat     240

ctgcagatta acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgctttgcg     300

attaaaggcg attattgggg ccagggcacc ctgctgaccg tgagcagc                  348


<210> 53
<211> 109
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 53
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              
Tyr Gly Ala Ser Thr Thr Ala Ser Gly Ile Pro Ala Arg Phe Ser Ala 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      
Ala Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 

<210> 54
<211> 327
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 54
gaaattgtga tgacccagag cccggcgacc ctgagcgtga gcccgggcga acgcgcgacc      60

ctgagctgcc gcgcgagcca gagcgtgagc agcaacctgg cgtggtatca gcagaaaccg     120

ggccaggcgc cgcgcctgat tatttatggc gcgagcacca ccgcgagcgg cattccggcg     180

cgctttagcg cgagcggcag cggcaccgat tttaccctga ccattagcag cctgcagagc     240

gaagattttg cggtgtatta ttgccagcag tataacaact ggccgccggc gtataccttt     300

ggccagggca ccaaactgga aattaaa                                         327


<210> 55
<211> 115
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 55
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Leu Leu Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 56
<211> 345
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 56
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg      60

agctgcaaag cgagcggcgg cacctttagc agctatgcga ttagctgggt gcgccaggcg     120

ccgggccagg gcctggaatg gatgggcggc attattccga tttttggcac cgcgaactat     180

gcgcagaaat ttcagggccg cgtgaccatt accgcggatg aaagcaccag caccgcgtat     240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcggcctg     300

ctgtggaact attggggcca gggcaccctg gtgaccgtga gcagc                     345


<210> 57
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 57
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 58
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 58
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60

attacctgcc gcgcgagcca ggatgtgaac accgcggtgg cgtggtatca gcagaaaccg     120

ggcaaagcgc cgaaactgct gatttatagc gcgagctttc tgtatagcgg cgtgccgagc     180

cgctttagcg gcagccgcag cggcaccgat tttaccctga ccattagcag cctgcagccg     240

gaagattttg cgacctatta ttgccagcag cattatacca ccccgccgac ctttggccag     300

ggcaccaaag tggaaattaa a                                               321


<210> 59
<211> 120
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 59
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 60
<211> 360
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 60
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg      60

agctgcgcgg cgagcggctt taacattaaa gatacctata ttcattgggt gcgccaggcg     120

ccgggcaaag gcctggaatg ggtggcgcgc atttatccga ccaacggcta tacccgctat     180

gcggatagcg tgaaaggccg ctttaccatt agcgcggata ccagcaaaaa caccgcgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcag ccgctggggc     300

ggcgatggct tttatgcgat ggattattgg ggccagggca ccctggtgac cgtgagcagc     360


<210> 61
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 61
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 62
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 62
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60

attacctgca aagcgagcca ggatgtgagc attggcgtgg cgtggtatca gcagaaaccg     120

ggcaaagcgc cgaaactgct gatttatagc gcgagctatc gctataccgg cgtgccgagc     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg     240

gaagattttg cgacctatta ttgccagcag tattatattt atccgtatac ctttggccag     300

ggcaccaaag tggaaattaa a                                               321


<210> 63
<211> 119
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 63
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          
Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  
Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 64
<211> 357
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 64
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg      60

agctgcgcgg cgagcggctt tacctttacc gattatacca tggattgggt gcgccaggcg     120

ccgggcaaag gcctggaatg ggtggcggat gtgaacccga acagcggcgg cagcatttat     180

aaccagcgct ttaaaggccg ctttaccctg agcgtggatc gcagcaaaaa caccctgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcaacctg     300

ggcccgagct tttattttga ttattggggc cagggcaccc tggtgaccgt gagcagc        357


<210> 65
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 65
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Ala 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Gly Tyr Leu His 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 66
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 66
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc      60

attacctgcc gcgcgagcca gagcattcgc agcgcgctga actggtatca gcagaaaccg     120

ggcaaagcgc cgaaactgct gatttatgcg gcgagcagcc tgcagagcgg cgtgccgagc     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg     240

gaagattttg cgacctatta ttgccagcag acctatggct atctgcatac ctttggccag     300

ggcaccaaac tggaaattaa a                                               321


<210> 67
<211> 121
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 67
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Glu Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Tyr Gly Gly Tyr Tyr Ser Ala Trp Met Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 68
<211> 363
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 68
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg      60

agctgcgcgg cgagcggctt tgattttgaa agctatgcga tgagctgggt gcgccaggcg     120

ccgggcaaag gcctggaatg ggtgagcgcg attagcggca gcggcggcag cacctattat     180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat     240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgctattat     300

ggcggctatt atagcgcgtg gatggattat tggggccagg gcaccctggt gaccgtgagc     360

agc                                                                   363


<210> 69
<211> 106
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 69
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 70
<211> 318
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 70
cagattgtgc tgagccagag cccggcgatt ctgagcgcga gcccgggcga aaaagtgacc      60

atgacctgcc gcgcgagcag cagcgtgagc tatattcatt ggtttcagca gaaaccgggc     120

agcagcccga aaccgtggat ttatgcgacc agcaacctgg cgagcggcgt gccggtgcgc     180

tttagcggca gcggcagcgg caccagctat agcctgacca ttagccgcgt ggaagcggaa     240

gatgcggcga cctattattg ccagcagtgg accagcaacc cgccgacctt tggcggcggc     300

accaaactgg aaattaaa                                                   318


<210> 71
<211> 121
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 71
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         
Ala Gly Thr Thr Val Thr Val Ser Ala 
        115                 120     

<210> 72
<211> 363
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 72
caggtgcagc tgcagcagcc gggcgcggaa ctggtgaaac cgggcgcgag cgtgaaaatg      60

agctgcaaag cgagcggcta tacctttacc agctataaca tgcattgggt gaaacagacc     120

ccgggccgcg gcctggaatg gattggcgcg atttatccgg gcaacggcga taccagctat     180

aaccagaaat ttaaaggcaa agcgaccctg accgcggata aaagcagcag caccgcgtat     240

atgcagctga gcagcctgac cagcgaagat agcgcggtgt attattgcgc gcgcagcacc     300

tattatggcg gcgattggta ttttaacgtg tggggcgcgg gcaccaccgt gaccgtgagc     360

gcg                                                                   363


<210> 73
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Light chain VL

<400> 73
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          
Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  
Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 74
<211> 321
<212> DNA
<213> Synthetic


<220> 
<223> Light chain VL

<400> 74
gatattctgc tgacccagag cccggtgatt ctgagcgtga gcccgggcga acgcgtgagc      60

tttagctgcc gcgcgagcca gagcattggc accaacattc attggtatca gcagcgcacc     120

aacggcagcc cgcgcctgct gattaaatat gcgagcgaaa gcattagcgg cattccgagc     180

cgctttagcg gcagcggcag cggcaccgat tttaccctga gcattaacag cgtggaaagc     240

gaagatattg cggattatta ttgccagcag aacaacaact ggccgaccac ctttggcgcg     300

ggcaccaaac tggaactgaa a                                               321


<210> 75
<211> 119
<212> PRT
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 75
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  
Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala 
        115                 

<210> 76
<211> 357
<212> DNA
<213> Synthetic


<220> 
<223> Heavy chain VH

<400> 76
caggtgcagc tgaaacagag cggcccgggc ctggtgcagc cgagccagag cctgagcatt      60

acctgcaccg tgagcggctt tagcctgacc aactatggcg tgcattgggt gcgccagagc     120

ccgggcaaag gcctggaatg gctgggcgtg atttggagcg gcggcaacac cgattataac     180

accccgttta ccagccgcct gagcattaac aaagataaca gcaaaagcca ggtgtttttt     240

aaaatgaaca gcctgcagag caacgatacc gcgatttatt attgcgcgcg cgcgctgacc     300

tattatgatt atgaatttgc gtattggggc cagggcaccc tggtgaccgt gagcgcg        357


<210> 77
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 77
Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               

<210> 78
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 78
Ile Gly Ser Tyr Gly Gly Gly Thr 
1               5               

<210> 79
<211> 10
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 79
Ala Arg Tyr Val Asn Phe Gly Met Asp Tyr 
1               5                   10  

<210> 80
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 80
Ile Gly Gly Ser Ser Ser Tyr Thr 
1               5               

<210> 81
<211> 10
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 81
Ala Arg Tyr Tyr Ser Tyr His Met Asp Tyr 
1               5                   10  

<210> 82
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 82
Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               

<210> 83
<211> 12
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 83
Ala Arg Gly Pro Val Tyr Ser Ser Val Phe Asp Tyr 
1               5                   10          

<210> 84
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 84
Ala Arg Arg Val Trp Gly Phe Asp Tyr 
1               5                   

<210> 85
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 85
Gly Phe Thr Phe Ser Thr Tyr Gly 
1               5               

<210> 86
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 86
Ile Ser Gly Gly Ser Ser Tyr Ile 
1               5               

<210> 87
<211> 12
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 87
Ala Arg Ile Leu Arg Gly Gly Ser Gly Met Asp Leu 
1               5                   10          

<210> 88
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 88
Gly Phe Ser Phe Ser Ser Thr Tyr 
1               5               

<210> 89
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 89
Ile Tyr Thr Gly Asp Gly Thr Asn 
1               5               

<210> 90
<211> 13
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 90
Ala Arg Pro Asp Ile Thr Tyr Gly Phe Ala Ile Asn Phe 
1               5                   10              

<210> 91
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 91
Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               

<210> 92
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 92
Ile Asn Pro Asp Ser Gly Gly Thr 
1               5               

<210> 93
<211> 19
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 93
Ala Arg Asp Gln Pro Leu Gly Tyr Cys Thr Asn Gly Val Cys Ser Tyr 
1               5                   10                  15      
Phe Asp Tyr 
            

<210> 94
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 94
Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               

<210> 95
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 95
Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               

<210> 96
<211> 11
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 96
Ala Arg Asp Leu Trp Gly Trp Tyr Phe Asp Tyr 
1               5                   10      

<210> 97
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 97
Gln Ser Ile Ser Ser Tyr 
1               5       

<210> 98
<400> 98
000

<210> 99
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 99
Gln Gln Tyr Gly Arg Asn Pro Pro Thr 
1               5                   

<210> 100
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 100
Gln Gln Tyr Gly Ser Ala Pro Pro Thr 
1               5                   

<210> 101
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 101
Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   

<210> 102
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 102
Gln Gln Tyr Gly Val Tyr Pro Phe Thr 
1               5                   

<210> 103
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 103
Ser Ser Asn Ile Gly Ala Gly Tyr Asn 
1               5                   

<210> 104
<400> 104
000

<210> 105
<211> 11
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 105
Ala Ala Trp Asp Lys Ser Ile Ser Gly Leu Val 
1               5                   10      

<210> 106
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 106
Gln Ser Ile Ser Ser Arg 
1               5       

<210> 107
<400> 107
000

<210> 108
<211> 10
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 108
Gln Cys Thr Gly Tyr Gly Ile Ser Trp Pro 
1               5                   10  

<210> 109
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 109
Gln Gly Ile Tyr Ser Trp 
1               5       

<210> 110
<400> 110
000

<210> 111
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 111
Gln Gln Ala Asn Ile Phe Pro Leu Thr 
1               5                   

<210> 112
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 112
Gln Ser Val Ser Ser Tyr 
1               5       

<210> 113
<400> 113
000

<210> 114
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 114
Gln Gln Arg Arg Asn Trp Pro Leu Thr 
1               5                   

<210> 115
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 115
Gly Tyr Ala Phe Thr Asn Tyr Trp 
1               5               

<210> 116
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 116
Ile Phe Pro Gly Ser Gly Asn Ile 
1               5               

<210> 117
<211> 12
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 117
Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr 
1               5                   10          

<210> 118
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 118
Ser Ser Tyr Ala Met Ser 
1               5       

<210> 119
<211> 10
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 119
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  

<210> 120
<211> 10
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 120
Gly Tyr Ala Ser Phe Val Gly Gly Tyr Phe 
1               5                   10  

<210> 121
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 121
Ser Gly Gly Tyr Ser Gly Asp His Phe 
1               5                   

<210> 122
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 122
Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               

<210> 123
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 123
Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               

<210> 124
<211> 20
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 124
Ala Lys Asp Met Gly Trp Gly Ser Gly Trp Arg Pro Tyr Tyr Tyr Tyr 
1               5                   10                  15      
Gly Met Asp Val 
            20  

<210> 125
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 125
Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               

<210> 126
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 126
Ile Asn Thr Tyr Thr Gly Glu Ser 
1               5               

<210> 127
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 127
Ala Arg Phe Ala Ile Lys Gly Asp Tyr 
1               5                   

<210> 128
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 128
Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               

<210> 129
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 129
Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               

<210> 130
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 130
Ala Arg Gly Leu Leu Trp Asn Tyr 
1               5               

<210> 131
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 131
Gly Phe Asn Ile Lys Asp Thr Tyr 
1               5               

<210> 132
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 132
Ile Tyr Pro Thr Asn Gly Tyr Thr 
1               5               

<210> 133
<211> 13
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 133
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10              

<210> 134
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 134
Gly Phe Thr Phe Thr Asp Tyr Thr 
1               5               

<210> 135
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 135
Val Asn Pro Asn Ser Gly Gly Ser 
1               5               

<210> 136
<211> 12
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 136
Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
1               5                   10          

<210> 137
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 137
Gly Phe Asp Phe Glu Ser Tyr Ala 
1               5               

<210> 138
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 138
Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               

<210> 139
<211> 14
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 139
Ala Arg Tyr Tyr Gly Gly Tyr Tyr Ser Ala Trp Met Asp Tyr 
1               5                   10                  

<210> 140
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 140
Gly Tyr Thr Phe Thr Ser Tyr Asn 
1               5               

<210> 141
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 141
Ile Tyr Pro Gly Asn Gly Asp Thr 
1               5               

<210> 142
<211> 14
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 142
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
1               5                   10                  

<210> 143
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> H CDR1

<400> 143
Gly Phe Ser Leu Thr Asn Tyr Gly 
1               5               

<210> 144
<211> 7
<212> PRT
<213> Synthetic


<220> 
<223> H CDR2

<400> 144
Ile Trp Ser Gly Gly Asn Thr 
1               5           

<210> 145
<211> 13
<212> PRT
<213> Synthetic


<220> 
<223> H CDR3

<400> 145
Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 
1               5                   10              

<210> 146
<211> 12
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 146
Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          

<210> 147
<400> 147
000

<210> 148
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 148
Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   

<210> 149
<211> 7
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 149
Pro Gly Ser Ser Ser Pro Tyr 
1               5           

<210> 150
<211> 5
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 150
Ser Tyr Asn Leu Phe 
1               5   

<210> 151
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 151
Gln Gln Ser Tyr Asp Ile Pro Tyr Thr 
1               5                   

<210> 152
<211> 11
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 152
Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      

<210> 153
<400> 153
000

<210> 154
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 154
Ala Gln Asn Leu Glu Ile Pro Arg Thr 
1               5                   

<210> 155
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 155
Gln Ser Val Ser Ser Asn 
1               5       

<210> 156
<400> 156
000

<210> 157
<211> 11
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 157
Gln Gln Tyr Asn Asn Trp Pro Pro Ala Tyr Thr 
1               5                   10      

<210> 158
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 158
Gln Asp Val Asn Thr Ala 
1               5       

<210> 159
<400> 159
000

<210> 160
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 160
Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   

<210> 161
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 161
Gln Asp Val Ser Ile Gly 
1               5       

<210> 162
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 162
Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr 
1               5                   

<210> 163
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 163
Gln Ser Ile Arg Ser Ala 
1               5       

<210> 164
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 164
Gln Gln Thr Tyr Gly Tyr Leu His Thr 
1               5                   

<210> 165
<211> 7
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 165
Ala Ser Ser Ser Val Ser Tyr 
1               5           

<210> 166
<400> 166
000

<210> 167
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 167
Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   

<210> 168
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> L CDR1

<400> 168
Gln Ser Ile Gly Thr Asn 
1               5       

<210> 169
<400> 169
000

<210> 170
<211> 9
<212> PRT
<213> Synthetic


<220> 
<223> L CDR3

<400> 170
Gln Gln Asn Asn Asn Trp Pro Thr Thr 
1               5                   

<210> 171
<211> 330
<212> PRT
<213> Synthetic


<220> 
<223> IgG1 LALA-sequence

<400> 171
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 172
<211> 11
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 172
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      

<210> 173
<211> 13
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 173
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro 
1               5                   10              

<210> 174
<211> 5
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 174
Asn Phe Ser Gln Pro 
1               5   

<210> 175
<211> 5
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 175
Lys Arg Thr Val Ala 
1               5   

<210> 176
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 176
Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               

<210> 177
<211> 10
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 177
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210> 178
<211> 15
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 178
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 179
<211> 18
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 179
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      
Lys Gly 
        

<210> 180
<211> 15
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 180
Thr His Thr Cys Pro Pro Cys Pro Glu Pro Lys Ser Ser Asp Lys 
1               5                   10                  15  

<210> 181
<211> 4
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 181
Gly Gly Gly Ser 
1               

<210> 182
<211> 13
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 182
Glu Ala Ala Lys Glu Ala Ala Lys Gly Gly Gly Gly Ser 
1               5                   10              

<210> 183
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 183
Glu Ala Ala Lys Glu Ala Ala Lys 
1               5               

<210> 184
<211> 330
<212> PRT
<213> Synthetic


<220> 
<223> IgG1 heavy chain constant region

<400> 184
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 185
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> IgG1 light chain constant region

<400> 185
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210> 186
<211> 327
<212> PRT
<213> Synthetic


<220> 
<223> Modified IgG4 heavy chain constant region

<400> 186
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn Arg Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         

<210> 187
<211> 327
<212> PRT
<213> Synthetic


<220> 
<223> Modified IgG4 heavy chain constant region

<400> 187
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         

<210> 188
<211> 327
<212> PRT
<213> Synthetic


<220> 
<223> Wild type IgG4 heavy chain constant region

<400> 188
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys 
                325         

<210> 189
<211> 103
<212> PRT
<213> Synthetic


<220> 
<223> Reference sequence CH1

<400> 189
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys 
            100             

<210> 190
<211> 107
<212> PRT
<213> Synthetic


<220> 
<223> Reference sequence CKappa

<400> 190
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210> 191
<211> 447
<212> PRT
<213> Synthetic


<220> 
<223> Binding domain B1 heavy chain

<400> 191
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Gly Ser Tyr Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Val Asn Phe Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val Ala Thr Gly Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210> 192
<211> 214
<212> PRT
<213> Synthetic


<220> 
<223> Binding domain B1 light chain

<400> 192
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Glu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Arg Asn Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Tyr Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Trp 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 193
<211> 223
<212> PRT
<213> Synthetic


<220> 
<223> Binding domain B2 heavy chain

<400> 193
Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      
Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
            20                  25                  30          
Tyr Trp Leu Gly Trp Val Lys Glu Arg Pro Gly His Gly Leu Glu Trp 
        35                  40                  45              
Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
    50                  55                  60                  
Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  
Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      
Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Glu Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             

<210> 194
<211> 220
<212> PRT
<213> Synthetic


<220> 
<223> Binding domain B2 light chain

<400> 194
Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Arg Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ala Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Lys Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210> 195
<211> 4
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<220> 
<221> VARIANT
<222> 3,4
<223> Wherein Xaa-Xaa is SG, SGSG, SGSGSG, SGSGSGSG, SGSGSGSGSG or
      SGSGSGSGSGSG

<400> 195
Ser Gly Ser Gly 
1               

<210> 196
<211> 6
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 196
Ser Gly Ser Gly Ser Gly 
1               5       

<210> 197
<211> 8
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 197
Ser Gly Ser Gly Ser Gly Ser Gly 
1               5               

<210> 198
<211> 10
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 198
Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10  

<210> 199
<211> 12
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 199
Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10          

<210> 200
<211> 14
<212> PRT
<213> Synthetic


<220> 
<223> Linker

<400> 200
Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10                  

