                         SEQUENCE LISTING

<110>  NEUWAY Pharma GmbH
 
<120>  Method for providing a VLP

<130>  60 856 K

<150>  PCT/EP2018/085699
<151>  2018-12-18

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from JC virus

<400>  1

Met Ala Pro Thr Lys Arg Lys Gly Glu Pro Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Arg Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Ser Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Lys Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  2
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from JC virus

<400>  2
atggctccca ccaagcgcaa gggcgagccc aaggaccccg tgcaagtgcc caagctgctg       60

atccgtggtg gtgtcgaggt gctggaagtc aagaccggcg tggactccat taccgaggtg      120

gagtgcttcc tcacccccga gatgggtgac cctgacgagc acctgagggg cttctccaag      180

tccatctcca tctccgacac cttcgagtcc gactccccca accgtgacat gctgccctgc      240

tactccgtgg ctcgtatccc cctgcccaac ctgaacgagg acctgacttg cggcaacatc      300

ctgatgtggg aggctgtgac cctcaagacc gaggtcatcg gcgtgacttc cctgatgaac      360

gtgcactcca acggccaggc tacccacgac aacggtgctg gcaagcccgt gcagggaacc      420

tccttccact tcttctccgt gggtggcgag gctctggaac tccagggcgt ggtgttcaac      480

taccgtacca agtaccccga cggcaccatc ttccccaaga acgctactgt gcagtcccaa      540

gtgatgaaca ccgagcacaa ggcttacctg gacaagaaca aggcctaccc cgtggagtgc      600

tgggtgcccg accccacccg taacgagaac acccgttact tcggcaccct gaccggtgga      660

gagaacgtgc cccccgtgct gcacatcacc aacaccgcta ccaccgtgct gctggacgag      720

ttcggtgtcg gtcccctgtg caagggcgac aacctgtacc tgtccgctgt ggacgtgtgc      780

ggcatgttca ccaaccgttc cggttcccag cagtggcgtg gcctgtcccg ctacttcaag      840

gtgcagctgc gcaagcgtcg tgtgaagaac ccctacccta tctccttcct gctgaccgac      900

ctgatcaacc gtcgtacccc tcgtgtggac ggccagccca tgtacggcat ggacgctcag      960

gtggaagagg tccgcgtgtt cgagggcacc gaggaattgc ccggcgaccc cgacatgatg     1020

cgttacgtgg acaagtacgg ccagctccag accaagatgc tgtaa                     1065


<210>  3
<211>  354
<212>  PRT
<213>  JC virus

<400>  3

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Ser Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Ser Leu Met Asn Val His Ser Asn Gly Gln Ala Ala 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  4
<211>  1065
<212>  DNA
<213>  JC virus

<400>  4
atggccccaa caaaaagaaa aggagaaagg aaggaccccg tgcaagttcc aaaacttctt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgctttt taactccaga aatgggtgac ccagatgagc atcttagggg ttttagtaag      180

tcaatatcta tatcagatac atttgaaagt gactccccaa atagggacat gcttccttgt      240

tacagtgtgg ccagaattcc actacccaat ctaaatgagg atctaacctg tggaaatata      300

ctcatgtggg aggctgtgac cttaaaaact gaggttatag gggtgacaag tttgatgaat      360

gtgcactcta atgggcaagc aactcatgac aatggtgcag ggaagccagt gcagggcacc      420

agctttcatt ttttttctgt tgggggggag gctttagaat tacagggggt gctttttaat      480

tacagaacaa agtacccaga tggaacaatt tttccaaaga atgccacagt gcaatctcaa      540

gtcatgaaca cagagcacaa ggcgtaccta gataagaaca aagcatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaaatgttc ctccagttct tcatataaca aacactgcca caacagtgtt gcttgatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttatact tgtcagctgt tgatgtctgt      780

ggcatgttta caaacaggtc tggttcccag cagtggagag gactctccag atattttaag      840

gtgcagctaa ggaaaaggag ggttaaaaac ccctacccaa tttctttcct tcttactgat      900

ttaattaaca gaaggactcc tagagttgat gggcagccta tgtatggcat ggatgctcaa      960

gtagaggagg ttagagtttt tgagggaaca gaggagcttc caggggaccc agacatgatg     1020

agatacgttg acaaatatgg acagttgcag acaaaaatgc tgtaa                     1065


