                         SEQUENCE LISTING

<110>  NEUWAY Pharma GmbH
 
<120>  VLP for the treatment of a lysosomal storage disease

<130>  60 212 K

<150>  PCT/EP2018/085699
<151>  2018-12-18

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly 
1               5                   10                  15      


Leu Ala Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp 
            20                  25                  30          


Leu Gly Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr 
        35                  40                  45              


Pro Asn Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe 
    50                  55                  60                  


Tyr Val Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr 
65                  70                  75                  80  


Gly Arg Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro 
                85                  90                  95      


Ser Ser Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val 
            100                 105                 110         


Leu Ala Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu 
        115                 120                 125             


Gly Val Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His 
    130                 135                 140                 


Arg Phe Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn 
145                 150                 155                 160 


Leu Thr Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln 
                165                 170                 175     


Gly Leu Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln 
            180                 185                 190         


Pro Pro Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His 
        195                 200                 205             


Asp Leu Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr 
    210                 215                 220                 


Tyr Ala Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe 
225                 230                 235                 240 


Ala Glu Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu 
                245                 250                 255     


Asp Ala Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu 
            260                 265                 270         


Leu Glu Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr 
        275                 280                 285             


Met Arg Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys 
    290                 295                 300                 


Gly Thr Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp 
305                 310                 315                 320 


Pro Gly His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu 
                325                 330                 335     


Asp Leu Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn 
            340                 345                 350         


Val Thr Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly 
        355                 360                 365             


Lys Ser Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu 
    370                 375                 380                 


Val Arg Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe 
385                 390                 395                 400 


Phe Thr Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys 
                405                 410                 415     


His Ala Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp 
            420                 425                 430         


Leu Ser Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala 
        435                 440                 445             


Gly Ala Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu 
    450                 455                 460                 


Lys Ala Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala 
465                 470                 475                 480 


Arg Gly Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr 
                485                 490                 495     


Pro Arg Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505                 


<210>  2
<211>  1530
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtccatgg gggcaccgcg gtccctcctc ctggccctgg ctgctggcct ggccgttgcc       60

cgtccgccca acatcgtgct gatctttgcc gacgacctcg gctatgggga cctgggctgc      120

tatgggcacc ccagctctac cactcccaac ctggaccagc tggcggcggg agggctgcgg      180

ttcacagact tctacgtgcc tgtgtctctg tgcacaccct ctagggccgc cctcctgacc      240

ggccggctcc cggttcggat gggcatgtac cctggcgtcc tggtgcccag ctcccggggg      300

ggcctgcccc tggaggaggt gaccgtggcc gaagtcctgg ctgcccgagg ctacctcaca      360

ggaatggccg gcaagtggca ccttggggtg gggcctgagg gggccttcct gcccccccat      420

cagggcttcc atcgatttct aggcatcccg tactcccacg accagggccc ctgccagaac      480

ctgacctgct tcccgccggc cactccttgc gacggtggct gtgaccaggg cctggtcccc      540

atcccactgt tggccaacct gtccgtggag gcgcagcccc cctggctgcc cggactagag      600

gcccgctaca tggctttcgc ccatgacctc atggccgacg cccagcgcca ggatcgcccc      660

ttcttcctgt actatgcctc tcaccacacc cactaccctc agttcagtgg gcagagcttt      720

gcagagcgtt caggccgcgg gccatttggg gactccctga tggagctgga tgcagctgtg      780

gggaccctga tgacagccat aggggacctg gggctgcttg aagagacgct ggtcatcttc      840

actgcagaca atggacctga gaccatgcgt atgtcccgag gcggctgctc cggtctcttg      900

cggtgtggaa agggaacgac ctacgagggc ggtgtccgag agcctgcctt ggccttctgg      960

ccaggtcata tcgctcccgg cgtgacccac gagctggcca gctccctgga cctgctgcct     1020

accctggcag ccctggctgg ggccccactg cccaatgtca ccttggatgg ctttgacctc     1080

agccccctgc tgctgggcac aggcaagagc cctcggcagt ctctcttctt ctacccgtcc     1140

tacccagacg aggtccgtgg ggtttttgct gtgcggactg gaaagtacaa ggctcacttc     1200

ttcacccagg gctctgccca cagtgatacc actgcagacc ctgcctgcca cgcctccagc     1260

tctctgactg ctcatgagcc cccgctgctc tatgacctgt ccaaggaccc tggtgagaac     1320

tacaacctgc tggggggtgt ggccggggcc accccagagg tgctgcaagc cctgaaacag     1380

cttcagctgc tcaaggccca gttagacgca gctgtgacct tcggccccag ccaggtggcc     1440

cggggcgagg accccgccct gcagatctgc tgtcatcctg gctgcacccc ccgcccagct     1500

tgctgccatt gcccagatcc ccatgcctga                                      1530


<210>  3
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from JC virus

<400>  3

Met Ala Pro Thr Lys Arg Lys Gly Glu Pro Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Arg Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Ser Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Lys Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  4
<211>  354
<212>  PRT
<213>  JC virus

<400>  4

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Ser Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Ser Leu Met Asn Val His Ser Asn Gly Gln Ala Ala 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  5
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from JC virus

<400>  5
atggctccca ccaagcgcaa gggcgagccc aaggaccccg tgcaagtgcc caagctgctg       60

atccgtggtg gtgtcgaggt gctggaagtc aagaccggcg tggactccat taccgaggtg      120

gagtgcttcc tcacccccga gatgggtgac cctgacgagc acctgagggg cttctccaag      180

tccatctcca tctccgacac cttcgagtcc gactccccca accgtgacat gctgccctgc      240

tactccgtgg ctcgtatccc cctgcccaac ctgaacgagg acctgacttg cggcaacatc      300

ctgatgtggg aggctgtgac cctcaagacc gaggtcatcg gcgtgacttc cctgatgaac      360

gtgcactcca acggccaggc tacccacgac aacggtgctg gcaagcccgt gcagggaacc      420

tccttccact tcttctccgt gggtggcgag gctctggaac tccagggcgt ggtgttcaac      480

taccgtacca agtaccccga cggcaccatc ttccccaaga acgctactgt gcagtcccaa      540

gtgatgaaca ccgagcacaa ggcttacctg gacaagaaca aggcctaccc cgtggagtgc      600

tgggtgcccg accccacccg taacgagaac acccgttact tcggcaccct gaccggtgga      660

gagaacgtgc cccccgtgct gcacatcacc aacaccgcta ccaccgtgct gctggacgag      720

ttcggtgtcg gtcccctgtg caagggcgac aacctgtacc tgtccgctgt ggacgtgtgc      780

ggcatgttca ccaaccgttc cggttcccag cagtggcgtg gcctgtcccg ctacttcaag      840

gtgcagctgc gcaagcgtcg tgtgaagaac ccctacccta tctccttcct gctgaccgac      900

ctgatcaacc gtcgtacccc tcgtgtggac ggccagccca tgtacggcat ggacgctcag      960

gtggaagagg tccgcgtgtt cgagggcacc gaggaattgc ccggcgaccc cgacatgatg     1020

cgttacgtgg acaagtacgg ccagctccag accaagatgc tgtaa                     1065


<210>  6
<211>  1065
<212>  DNA
<213>  JC virus

<400>  6
atggccccaa caaaaagaaa aggagaaagg aaggaccccg tgcaagttcc aaaacttctt       60

ataagaggag gagtagaagt tctagaagtt aaaactgggg ttgactcaat tacagaggta      120

gaatgctttt taactccaga aatgggtgac ccagatgagc atcttagggg ttttagtaag      180

tcaatatcta tatcagatac atttgaaagt gactccccaa atagggacat gcttccttgt      240

tacagtgtgg ccagaattcc actacccaat ctaaatgagg atctaacctg tggaaatata      300

ctcatgtggg aggctgtgac cttaaaaact gaggttatag gggtgacaag tttgatgaat      360

gtgcactcta atgggcaagc aactcatgac aatggtgcag ggaagccagt gcagggcacc      420

agctttcatt ttttttctgt tgggggggag gctttagaat tacagggggt gctttttaat      480

tacagaacaa agtacccaga tggaacaatt tttccaaaga atgccacagt gcaatctcaa      540

gtcatgaaca cagagcacaa ggcgtaccta gataagaaca aagcatatcc tgttgaatgt      600

tgggttcctg atcccaccag aaatgaaaac acaagatatt ttgggacact aacaggagga      660

gaaaatgttc ctccagttct tcatataaca aacactgcca caacagtgtt gcttgatgaa      720

tttggtgttg ggccactttg caaaggtgac aacttatact tgtcagctgt tgatgtctgt      780

ggcatgttta caaacaggtc tggttcccag cagtggagag gactctccag atattttaag      840

gtgcagctaa ggaaaaggag ggttaaaaac ccctacccaa tttctttcct tcttactgat      900

ttaattaaca gaaggactcc tagagttgat gggcagccta tgtatggcat ggatgctcaa      960

gtagaggagg ttagagtttt tgagggaaca gaggagcttc caggggaccc agacatgatg     1020

agatacgttg acaaatatgg acagttgcag acaaaaatgc tgtaa                     1065


<210>  7
<211>  1130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pFAR4 polynucleotide

<400>  7
ggtaccgagc tcttacgcgt gctagcccgg gctcgagatc tgcgatctaa gtaagcttcc       60

gggccccccc gccatggggt atcgataatg atatcgaatt cctgcagcgg ggatccacta      120

gttctagagc ggccgccacc gcggtggaca gctggctgtc gacgaagtac tgaccggtct      180

taggcctaaa aaaaatcctt agctttcgct aaggatctgc agtggggtgg ctaatgggat      240

tcgaacccac gacaactgga tttagaatcc agggctctac caactgagct atagccaccg      300

aattgtgcgt tacaagtatt acacaaagtt ttttatgttg agaatatttt tttgatgggg      360

cgcgacttat ttttgatcgt tcgctcaaag aagcggcgcg tcatgaccaa aatcccttaa      420

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga      480

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg      540

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc      600

agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca ccacttcaag      660

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc      720

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg      780

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac      840

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga      900

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt      960

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     1020

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     1080

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt                1130


