﻿                         序列表

<110>  四川大学华西医院

<120>  基因工程修饰的双靶点嵌合抗原受体及其用途

<130>  G19P0010K

<141>  2019-11-12

<150>  201811567513.5
<151>  2018-12-20

<160>  26

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  373
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val Arg 
145                 150                 155                 160 
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro Tyr 
                165                 170                 175     
Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp Pro 
    210                 215                 220                 
Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
225                 230                 235                 240 
Ala Ala Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
                245                 250                 255     
Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            260                 265                 270         
Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        275                 280                 285             
His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    290                 295                 300                 
Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
305                 310                 315                 320 
Tyr Cys Asn His Arg Asn Arg Phe Ser Val Val Lys Arg Gly Arg Lys 
                325                 330                 335     
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             
Gly Gly Cys Glu Leu 
    370             

<210>  2
<211>  1122
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  2
gacatccaaa tgacccagag ccctagctcc ctgtccgcta gcgtgggcga cagggtgacc        60
atcacctgca gagccagcca ggacgtgagc accgccgtgg cctggtacca gcagaagccc       120
ggcaaggccc ccaagctgct gatctacagc gcctccttcc tgtactccgg cgtgccctcc       180
agatttagcg gcagcggcag cggcacagac ttcaccctca ccatcagctc cctgcagcct       240
gaggacttcg ccacatacta ctgccagcag tacctctacc accctgccac cttcggccaa       300
ggcaccaagg tggagatcaa gggcggcgga ggttctggcg gaggcggctc cggaggagga       360
ggcagcgaag tgcagctggt ggagagcgga ggaggactgg tgcagcctgg cggaagcctg       420
aggctgagct gtgctgccag cggcttcacc ttctccgact cctggattca ttgggtcagg       480
caggcccccg gaaaaggact ggagtgggtc gcctggatct ccccttacgg cggcagcacc       540
tactacgccg acagcgtgaa gggcaggttc accatcagcg ccgataccag caagaacacc       600
gcctacctgc agatgaactc cctgagggct gaggacaccg ccgtgtacta ctgcgccagg       660
aggcactggc ctggcggatt cgactactgg ggccagggca ccctggtgac cgtgtccgcc       720
gccgccgcct tcgtgcctgt gtttctgccc gccaagccca ccaccacacc tgctcccaga       780
cctcccacac ctgcccctac catcgctagc cagcccctga gcctgagacc cgaggcttgt       840
aggcctgctg ctggcggagc cgtgcacaca agaggcctgg acttcgcctg cgacatctac       900
atctgggccc ccctggccgg aacatgtgga gtgctgctgc tgagcctggt gatcaccctg       960
tactgcaacc acaggaacag gttcagcgtg gtgaagaggg gcaggaagaa gctgctgtac      1020
atcttcaagc agcccttcat gaggcccgtg cagaccaccc aggaggagga tggctgcagc      1080
tgcaggttcc ctgaagagga ggagggcggc tgcgagctgt ga                         1122

<210>  3
<211>  482
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
            20                  25                  30          
Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              
Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  
Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile 
65                  70                  75                  80  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      
Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         
Tyr Gly Ser Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gln Ala Gln Val Val Glu Ser Gly Gly Gly Val Val Gln Ser Gly Arg 
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
                165                 170                 175     
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
        195                 200                 205             
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 
Ala Arg Asp His Tyr Gly Ser Gly Val His His Tyr Phe Tyr Tyr Gly 
                245                 250                 255     
Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Lys Ile 
            260                 265                 270         
Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
        275                 280                 285             
Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
    290                 295                 300                 
Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 
Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     
Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         
Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             
Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ala Pro Ala Tyr Gln Gln 
    370                 375                 380                 
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     
Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 
Pro Arg 
        

<210>  4
<211>  1446
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  4
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg        60
ccggagatcg tgctgacaca gagccctggc accctgagcc tgtcccccgg cgaaagagcc       120
accctgtcct gcagagccag ccagagcgtg agcagctcct atctggcctg gtaccagcag       180
aagcctggcc aggcccccag actcctgatc tacggcgcca gcagcagagc caccggcatc       240
cccgatagat tcagcggctc cggcagcgga accgacttta ccctgaccat ctccagactg       300
gagcccgagg actttgccgt gtactactgc cagcagtacg gcagcagccc cctgacattc       360
ggcggcggca caaaggtgga gatcaaaggc ggcggaggtt ctggaggagg aggaagcgga       420
ggaggaggca gccaggctca ggtggtcgaa agcggcggag gagtggtgca gagcggaagg       480
tccctgaggc tgagctgcgc tgctagcggc tttgccttct cctcctacgg catgcactgg       540
gtgagacagg cccctggcaa gggcctggaa tgggtggctg tgatctggta cgacggcagc       600
aacaagtact acgccgacag cgtgaggggc aggttcacca tcagcaggga caacagcgaa       660
aacaccctgt acctgcagat gaacagcctc agggccgagg ataccgccgt gtattattgc       720
gccagggatc actacggaag cggcgtgcac cattacttct attacggcct ggacgtgtgg       780
ggccagggca caacagtgac cgtgtccagc aaaattgaag ttatgtatcc tcctccttac       840
ctagacaatg agaagagcaa tggaaccatt atccatgtga aagggaaaca cctttgtcca       900
agtcccctat ttcccggacc ttctaagccc ttttgggtgc tggtggtggt tggtggagtc       960
ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      1020
aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      1080
cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccgccccc      1140
gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag      1200
tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgcagaga      1260
aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc      1320
tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac      1380
cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc      1440
cctcgc                                                                 1446

<210>  5
<211>  475
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro Met Gln Val Gln Leu Gln Gln Ser Gly Pro Glu 
            20                  25                  30          
Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              
Tyr Pro Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  
Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser 
65                  70                  75                  80  
Thr Phe Ala Asp Asp Phe Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr 
                85                  90                  95      
Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp 
            100                 105                 110         
Ser Ala Thr Tyr Phe Cys Ala Arg Trp Glu Val Tyr His Gly Tyr Val 
        115                 120                 125             
Pro Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
145                 150                 155                 160 
Thr Gln Ser His Lys Phe Leu Ser Thr Ser Val Gly Asp Arg Val Ser 
                165                 170                 175     
Ile Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr 
            180                 185                 190         
Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
        195                 200                 205             
Ser Arg Tyr Thr Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly 
    210                 215                 220                 
Pro Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
225                 230                 235                 240 
Val Tyr Phe Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser 
                245                 250                 255     
Gly Thr Lys Leu Glu Ile Lys Lys Ile Glu Val Met Tyr Pro Pro Pro 
            260                 265                 270         
Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
        275                 280                 285             
Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
    290                 295                 300                 
Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 
Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                325                 330                 335     
Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         
Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             
Tyr Arg Ser Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    370                 375                 380                 
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
385                 390                 395                 400 
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
                405                 410                 415     
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            420                 425                 430         
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        435                 440                 445             
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    450                 455                 460                 
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475 

<210>  6
<211>  1428
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  6
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg        60
ccgatgcagg tacaactgca gcagtcagga cctgaactga agaagcctgg agagacagtc       120
aagatctcct gcaaggcctc tgggtatcct ttcacaaact atggaatgaa ctgggtgaag       180
caggctccag gacagggttt aaagtggatg ggctggatta acacctccac tggagagtca       240
acatttgctg atgacttcaa gggacggttt gacttctctt tggaaacctc tgccaacact       300
gcctatttgc agatcaacaa cctcaaaagt gaagactcgg ctacatattt ctgtgcaaga       360
tgggaggttt accacggcta cgttccttac tggggccaag ggaccacggt caccgtttcc       420
tctggcggtg gcggttctgg tggcggtggc tccggcggtg gcggttctga catccagctg       480
acccagtctc acaaattcct gtccacttca gtaggagaca gggtcagcat cacctgcaag       540
gccagtcagg atgtgtataa tgctgttgcc tggtatcaac agaaaccagg acaatctcct       600
aaacttctga tttactcggc atcctcccgg tacactggag tcccttctcg cttcactggc       660
agtggctctg ggccggattt cactttcacc atcagcagtg tgcaggctga agacctggca       720
gtttatttct gtcagcaaca ttttcgtact ccattcacgt tcggctcggg gacaaaattg       780
gagatcaaaa aaattgaagt tatgtatcct cctccttacc tagacaatga gaagagcaat       840
ggaaccatta tccatgtgaa agggaaacac ctttgtccaa gtcccctatt tcccggacct       900
tctaagccct tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta       960
gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagcaggct cctgcacagt      1020
gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat      1080
gccccaccac gcgacttcgc agcctatcgc tccgcccccg cgtaccagca gggccagaac      1140
cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga      1200
cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc      1260
ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa      1320
ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc      1380
aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctaa                   1428

<210>  7
<211>  22
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
1               5                   10                  15      
Glu Glu Asn Pro Gly Pro 
            20          

<210>  8
<211>  66
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  8
agcggcagcg gcgagggaag aggaagcctg ctgacctgcg gcgatgtgga ggagaatccc        60
ggcccc                                                                   66

<210>  9
<211>  4
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Arg Arg Lys Arg 
1               

<210>  10
<211>  12
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  10
aggaggaaga ga                                                            12

<210>  11
<211>  21
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro 
            20      

<210>  12
<211>  63
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  12
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg        60
ccg                                                                      63

<210>  13
<211>  242
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Met Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
1               5                   10                  15      
Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn 
            20                  25                  30          
Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp 
        35                  40                  45              
Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp 
    50                  55                  60                  
Phe Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala 
65                  70                  75                  80  
Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Ser Ala Thr Tyr Phe 
                85                  90                  95      
Cys Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser His Lys 
    130                 135                 140                 
Phe Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
145                 150                 155                 160 
Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     
Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly 
            180                 185                 190         
Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe 
        195                 200                 205             
Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln 
    210                 215                 220                 
Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
225                 230                 235                 240 
Ile Lys 
        

<210>  14
<211>  726
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  14
atgcaggtac aactgcagca gtcaggacct gaactgaaga agcctggaga gacagtcaag        60
atctcctgca aggcctctgg gtatcctttc acaaactatg gaatgaactg ggtgaagcag       120
gctccaggac agggtttaaa gtggatgggc tggattaaca cctccactgg agagtcaaca       180
tttgctgatg acttcaaggg acggtttgac ttctctttgg aaacctctgc caacactgcc       240
tatttgcaga tcaacaacct caaaagtgaa gactcggcta catatttctg tgcaagatgg       300
gaggtttacc acggctacgt tccttactgg ggccaaggga ccacggtcac cgtttcctct       360
ggcggtggcg gttctggtgg cggtggctcc ggcggtggcg gttctgacat ccagctgacc       420
cagtctcaca aattcctgtc cacttcagta ggagacaggg tcagcatcac ctgcaaggcc       480
agtcaggatg tgtataatgc tgttgcctgg tatcaacaga aaccaggaca atctcctaaa       540
cttctgattt actcggcatc ctcccggtac actggagtcc cttctcgctt cactggcagt       600
ggctctgggc cggatttcac tttcaccatc agcagtgtgc aggctgaaga cctggcagtt       660
tatttctgtc agcaacattt tcgtactcca ttcacgttcg gctcggggac aaaattggag       720
atcaaa                                                                  726

<210>  15
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  15
Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
1               5                   10                  15      
Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
            20                  25                  30          
Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
        35                  40                  45              
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    50                  55                  60                  
Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
65                  70                  75                  80  
Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                85                  90                  95      
Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105             

<210>  16
<211>  324
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  16
aaaattgaag ttatgtatcc tcctccttac ctagacaatg agaagagcaa tggaaccatt        60
atccatgtga aagggaaaca cctttgtcca agtcccctat ttcccggacc ttctaagccc       120
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       180
gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg       240
aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca       300
cgcgacttcg cagcctatcg ctcc                                              324

<210>  17
<211>  104
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  17
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
1               5                   10                  15      
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            20                  25                  30          
Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
        35                  40                  45              
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    50                  55                  60                  
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
65                  70                  75                  80  
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                85                  90                  95      
His Met Gln Ala Leu Pro Pro Arg 
            100                 

<210>  18
<211>  315
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  18
gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga        60
gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg       120
cagagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg       180
gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc       240
ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc       300
ctgccccctc gctaa                                                        315

<210>  19
<211>  26
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  19
Arg Arg Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
1               5                   10                  15      
Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25      

<210>  20
<211>  78
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  20
agcggcagcg gcgagggaag aggaagcctg ctgacctgcg gcgatgtgga ggagaatccc        60
ggccccagga ggaagaga                                                      78

<210>  21
<211>  240
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 
Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val Arg 
145                 150                 155                 160 
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro Tyr 
                165                 170                 175     
Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         
Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp Pro 
    210                 215                 220                 
Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
225                 230                 235                 240 

<210>  22
<211>  720
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  22
gacatccaaa tgacccagag ccctagctcc ctgtccgcta gcgtgggcga cagggtgacc        60
atcacctgca gagccagcca ggacgtgagc accgccgtgg cctggtacca gcagaagccc       120
ggcaaggccc ccaagctgct gatctacagc gcctccttcc tgtactccgg cgtgccctcc       180
agatttagcg gcagcggcag cggcacagac ttcaccctca ccatcagctc cctgcagcct       240
gaggacttcg ccacatacta ctgccagcag tacctctacc accctgccac cttcggccaa       300
ggcaccaagg tggagatcaa gggcggcgga ggttctggcg gaggcggctc cggaggagga       360
ggcagcgaag tgcagctggt ggagagcgga ggaggactgg tgcagcctgg cggaagcctg       420
aggctgagct gtgctgccag cggcttcacc ttctccgact cctggattca ttgggtcagg       480
caggcccccg gaaaaggact ggagtgggtc gcctggatct ccccttacgg cggcagcacc       540
tactacgccg acagcgtgaa gggcaggttc accatcagcg ccgataccag caagaacacc       600
gcctacctgc agatgaactc cctgagggct gaggacaccg ccgtgtacta ctgcgccagg       660
aggcactggc ctggcggatt cgactactgg ggccagggca ccctggtgac cgtgtccgcc       720

<210>  23
<211>  91
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  23
Ala Ala Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
1               5                   10                  15      
Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            20                  25                  30          
Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        35                  40                  45              
His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    50                  55                  60                  
Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
65                  70                  75                  80  
Tyr Cys Asn His Arg Asn Arg Phe Ser Val Val 
                85                  90      

<210>  24
<211>  273
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  24
gcggccgcat tcgtgccggt cttcctgcca gcgaagccca ccacgacgcc agcgccgcga        60
ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc       120
cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac       180
atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt       240
tactgcaacc acaggaaccg tttctctgtt gtt                                    273

<210>  25
<211>  42
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  25
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          

<210>  26
<211>  126
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  26
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa        60
actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt       120
gaactg                                                                  126

