                         SEQUENCE LISTING

<110>  а˼Ƽ޹˾
 
<120>  һֿĿĹӦ

<130>  BY19DX0991FPPC-CN

<160>  26    

<170>  PatentIn version 3.3

<210>  1
<211>  2556
<212>  PRT
<213>  ˹ϳ


<220>
<221>  misc_feature
<222>  (891)..(891)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Arg Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Pro Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Met Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg Leu Arg Gly Thr Cys Gln Asp Pro Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ser Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Ile Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Lys Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Ala Gly Ala Lys Gly 
    850                 855                 860                 


Gln Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg 
865                 870                 875                 880 


His Gly Ala Ser Cys Gln Asn Thr His Gly Xaa Tyr Arg Cys His Cys 
                885                 890                 895     


Gln Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys 
            900                 905                 910         


Arg Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn 
        915                 920                 925             


Thr Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu 
    930                 935                 940                 


Glu Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn 
945                 950                 955                 960 


Cys Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe 
                965                 970                 975     


Ser Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser 
            980                 985                 990         


Cys Phe Asn Gly Gly Thr Cys Val  Asp Gly Ile Asn Ser  Phe Thr Cys 
        995                 1000                 1005             


Leu Cys  Pro Pro Gly Phe Thr  Gly Ser Tyr Cys Gln  His Val Val 
    1010                 1015                 1020             


Asn Glu  Cys Asp Ser Arg Pro  Cys Leu Leu Gly Gly  Thr Cys Gln 
    1025                 1030                 1035             


Asp Gly  Arg Gly Leu His Arg  Cys Thr Cys Pro Gln  Gly Tyr Thr 
    1040                 1045                 1050             


Gly Pro  Asn Cys Gln Asn Leu  Val His Trp Cys Asp  Ser Ser Pro 
    1055                 1060                 1065             


Cys Lys  Asn Gly Gly Lys Cys  Trp Gln Thr His Thr  Gln Tyr Arg 
    1070                 1075                 1080             


Cys Glu  Cys Pro Ser Gly Trp  Thr Gly Leu Tyr Cys  Asp Val Pro 
    1085                 1090                 1095             


Ser Val  Ser Cys Glu Val Ala  Ala Gln Arg Gln Gly  Val Asp Val 
    1100                 1105                 1110             


Ala Arg  Leu Cys Gln His Gly  Gly Leu Cys Val Asp  Ala Gly Asn 
    1115                 1120                 1125             


Thr His  His Cys Arg Cys Gln  Ala Gly Tyr Thr Gly  Ser Tyr Cys 
    1130                 1135                 1140             


Glu Asp  Leu Val Asp Glu Cys  Ser Pro Ser Pro Cys  Gln Asn Gly 
    1145                 1150                 1155             


Ala Thr  Cys Thr Asp Tyr Leu  Gly Gly Tyr Ser Cys  Lys Cys Val 
    1160                 1165                 1170             


Ala Gly  Tyr His Gly Val Asn  Cys Ser Glu Glu Ile  Asp Glu Cys 
    1175                 1180                 1185             


Leu Ser  His Pro Cys Gln Asn  Gly Gly Thr Cys Leu  Asp Leu Pro 
    1190                 1195                 1200             


Asn Thr  Tyr Lys Cys Ser Cys  Pro Arg Gly Thr Gln  Gly Val His 
    1205                 1210                 1215             


Cys Glu  Ile Asn Val Asp Asp  Cys Asn Pro Pro Val  Asp Pro Val 
    1220                 1225                 1230             


Ser Arg  Ser Pro Lys Cys Phe  Asn Asn Gly Thr Cys  Val Asp Gln 
    1235                 1240                 1245             


Val Gly  Gly Tyr Ser Cys Thr  Cys Pro Pro Gly Phe  Val Gly Glu 
    1250                 1255                 1260             


Arg Cys  Glu Gly Asp Val Asn  Glu Cys Leu Ser Asn  Pro Cys Asp 
    1265                 1270                 1275             


Ala Arg  Gly Thr Gln Asn Cys  Val Gln Arg Val Asn  Asp Phe His 
    1280                 1285                 1290             


Cys Glu  Cys Arg Ala Gly His  Thr Gly Arg Arg Cys  Glu Ser Val 
    1295                 1300                 1305             


Ile Asn  Gly Cys Lys Gly Lys  Pro Cys Lys Asn Gly  Gly Thr Cys 
    1310                 1315                 1320             


Ala Val  Ala Ser Asn Thr Ala  Arg Gly Phe Ile Cys  Lys Cys Pro 
    1325                 1330                 1335             


Ala Gly  Phe Glu Gly Ala Thr  Cys Glu Asn Asp Ala  Arg Thr Cys 
    1340                 1345                 1350             


Gly Ser  Leu Arg Cys Leu Asn  Gly Gly Thr Cys Ile  Ser Gly Pro 
    1355                 1360                 1365             


Arg Ser  Pro Thr Cys Leu Cys  Leu Gly Pro Phe Thr  Gly Pro Glu 
    1370                 1375                 1380             


Cys Gln  Phe Pro Ala Ser Ser  Pro Cys Leu Gly Gly  Asn Pro Cys 
    1385                 1390                 1395             


Tyr Asn  Gln Gly Thr Cys Glu  Pro Thr Ser Glu Ser  Pro Phe Tyr 
    1400                 1405                 1410             


Arg Cys  Leu Cys Pro Ala Lys  Phe Asn Gly Leu Leu  Cys His Ile 
    1415                 1420                 1425             


Leu Asp  Tyr Ser Phe Gly Gly  Gly Ala Gly Arg Asp  Ile Pro Pro 
    1430                 1435                 1440             


Pro Leu  Ile Glu Glu Ala Cys  Glu Leu Pro Glu Cys  Gln Glu Asp 
    1445                 1450                 1455             


Ala Gly  Asn Lys Val Cys Ser  Leu Gln Cys Asn Asn  His Ala Cys 
    1460                 1465                 1470             


Gly Trp  Asp Gly Gly Asp Cys  Ser Leu Asn Phe Asn  Asp Pro Trp 
    1475                 1480                 1485             


Lys Asn  Cys Thr Gln Ser Leu  Gln Cys Trp Lys Tyr  Phe Ser Asp 
    1490                 1495                 1500             


Gly His  Cys Asp Ser Gln Cys  Asn Ser Ala Gly Cys  Leu Phe Asp 
    1505                 1510                 1515             


Gly Phe  Asp Cys Gln Arg Ala  Glu Gly Gln Cys Asn  Pro Leu Tyr 
    1520                 1525                 1530             


Asp Gln  Tyr Cys Lys Asp His  Phe Ser Asp Gly His  Cys Asp Gln 
    1535                 1540                 1545             


Gly Cys  Asn Ser Ala Glu Cys  Glu Trp Asp Gly Leu  Asp Cys Ala 
    1550                 1555                 1560             


Glu His  Val Pro Glu Arg Leu  Ala Ala Gly Thr Leu  Val Val Val 
    1565                 1570                 1575             


Val Leu  Met Pro Pro Glu Gln  Leu Arg Asn Ser Ser  Phe His Phe 
    1580                 1585                 1590             


Leu Arg  Glu Leu Ser Arg Val  Leu His Thr Asn Val  Val Phe Lys 
    1595                 1600                 1605             


Arg Asp  Ala His Gly Gln Gln  Met Ile Phe Pro Tyr  Tyr Gly Arg 
    1610                 1615                 1620             


Glu Glu  Glu Leu Arg Lys His  Pro Ile Lys Arg Ala  Ala Glu Gly 
    1625                 1630                 1635             


Trp Ala  Ala Pro Asp Ala Leu  Leu Gly Gln Val Lys  Ala Ser Leu 
    1640                 1645                 1650             


Leu Pro  Gly Gly Ser Glu Gly  Gly Arg Arg Arg Arg  Glu Leu Asp 
    1655                 1660                 1665             


Pro Met  Asp Val Arg Gly Ser  Ile Val Tyr Leu Glu  Ile Asp Asn 
    1670                 1675                 1680             


Arg Gln  Cys Val Gln Ala Ser  Ser Gln Cys Phe Gln  Ser Ala Thr 
    1685                 1690                 1695             


Asp Val  Ala Ala Phe Leu Gly  Ala Leu Ala Ser Leu  Gly Ser Leu 
    1700                 1705                 1710             


Asn Ile  Pro Tyr Lys Ile Glu  Ala Val Gln Ser Glu  Thr Val Glu 
    1715                 1720                 1725             


Pro Pro  Pro Pro Ala Gln Leu  His Phe Met Tyr Val  Ala Ala Ala 
    1730                 1735                 1740             


Ala Phe  Val Leu Leu Phe Phe  Val Gly Cys Gly Val  Leu Leu Ser 
    1745                 1750                 1755             


Arg Lys  Arg Arg Arg Gln His  Gly Gln Leu Trp Phe  Pro Glu Gly 
    1760                 1765                 1770             


Phe Lys  Val Ser Glu Ala Ser  Lys Lys Lys Arg Arg  Glu Pro Leu 
    1775                 1780                 1785             


Gly Glu  Asp Ser Val Gly Leu  Lys Pro Leu Lys Asn  Ala Ser Asp 
    1790                 1795                 1800             


Gly Ala  Leu Met Asp Asp Asn  Gln Asn Glu Trp Gly  Asp Glu Asp 
    1805                 1810                 1815             


Leu Glu  Thr Lys Lys Phe Arg  Phe Glu Glu Pro Val  Val Leu Pro 
    1820                 1825                 1830             


Asp Leu  Asp Asp Gln Thr Asp  His Arg Gln Trp Thr  Gln Gln His 
    1835                 1840                 1845             


Leu Asp  Ala Ala Asp Leu Arg  Met Ser Ala Met Ala  Pro Thr Pro 
    1850                 1855                 1860             


Pro Gln  Gly Glu Val Asp Ala  Asp Cys Met Asp Val  Asn Val Arg 
    1865                 1870                 1875             


Gly Pro  Asp Gly Phe Thr Pro  Leu Met Ile Ala Ser  Cys Ser Gly 
    1880                 1885                 1890             


Gly Gly  Leu Glu Thr Gly Asn  Ser Glu Glu Glu Glu  Asp Ala Pro 
    1895                 1900                 1905             


Ala Val  Ile Ser Asp Phe Ile  Tyr Gln Gly Ala Ser  Leu His Asn 
    1910                 1915                 1920             


Gln Thr  Asp Arg Thr Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg 
    1925                 1930                 1935             


Tyr Ser  Arg Ser Asp Ala Ala  Lys Arg Leu Leu Glu  Ala Ser Ala 
    1940                 1945                 1950             


Asp Ala  Asn Ile Gln Asp Asn  Met Gly Arg Thr Pro  Leu His Ala 
    1955                 1960                 1965             


Ala Val  Ser Ala Asp Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg 
    1970                 1975                 1980             


Asn Arg  Ala Thr Asp Leu Asp  Ala Arg Met His Asp  Gly Thr Thr 
    1985                 1990                 1995             


Pro Leu  Ile Leu Ala Ala Arg  Leu Ala Val Glu Gly  Met Leu Glu 
    2000                 2005                 2010             


Asp Leu  Ile Asn Ser His Ala  Asp Val Asn Ala Val  Asp Asp Leu 
    2015                 2020                 2025             


Gly Lys  Ser Ala Leu His Trp  Ala Ala Ala Val Asn  Asn Val Asp 
    2030                 2035                 2040             


Ala Ala  Val Val Leu Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln 
    2045                 2050                 2055             


Asn Asn  Arg Glu Glu Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly 
    2060                 2065                 2070             


Ser Tyr  Glu Thr Ala Lys Val  Leu Leu Asp His Phe  Ala Asn Arg 
    2075                 2080                 2085             


Asp Ile  Thr Asp His Met Asp  Arg Leu Pro Arg Asp  Ile Ala Gln 
    2090                 2095                 2100             


Glu Arg  Met His His Asp Ile  Val Arg Leu Leu Asp  Glu Tyr Asn 
    2105                 2110                 2115             


Leu Val  Arg Ser Pro Gln Leu  His Gly Ala Pro Leu  Gly Gly Thr 
    2120                 2125                 2130             


Pro Thr  Leu Ser Pro Pro Leu  Cys Ser Pro Asn Gly  Tyr Leu Gly 
    2135                 2140                 2145             


Ser Leu  Lys Pro Gly Val Gln  Gly Lys Lys Val Arg  Lys Pro Ser 
    2150                 2155                 2160             


Ser Lys  Gly Leu Ala Cys Gly  Ser Lys Glu Ala Lys  Asp Leu Lys 
    2165                 2170                 2175             


Ala Arg  Arg Lys Lys Ser Gln  Asp Gly Lys Gly Cys  Leu Leu Asp 
    2180                 2185                 2190             


Ser Ser  Gly Met Leu Ser Pro  Val Asp Ser Leu Glu  Ser Pro His 
    2195                 2200                 2205             


Gly Tyr  Leu Ser Asp Val Ala  Ser Pro Pro Leu Leu  Pro Ser Pro 
    2210                 2215                 2220             


Phe Gln  Gln Ser Pro Ser Val  Pro Leu Asn His Leu  Pro Gly Met 
    2225                 2230                 2235             


Pro Asp  Thr His Leu Gly Ile  Gly His Leu Asn Val  Ala Ala Lys 
    2240                 2245                 2250             


Pro Glu  Met Ala Ala Leu Gly  Gly Gly Gly Arg Leu  Ala Phe Glu 
    2255                 2260                 2265             


Thr Gly  Pro Pro Arg Leu Ser  His Leu Pro Val Ala  Ser Gly Thr 
    2270                 2275                 2280             


Ser Thr  Val Leu Gly Ser Ser  Ser Gly Gly Ala Leu  Asn Phe Thr 
    2285                 2290                 2295             


Val Gly  Gly Ser Thr Ser Leu  Asn Gly Gln Cys Glu  Trp Leu Ser 
    2300                 2305                 2310             


Arg Leu  Gln Ser Gly Met Val  Pro Asn Gln Tyr Asn  Pro Leu Arg 
    2315                 2320                 2325             


Gly Ser  Val Ala Pro Gly Pro  Leu Ser Thr Gln Ala  Pro Ser Leu 
    2330                 2335                 2340             


Gln His  Gly Met Val Gly Pro  Leu His Ser Ser Leu  Ala Ala Ser 
    2345                 2350                 2355             


Ala Leu  Ser Gln Met Met Ser  Tyr Gln Gly Leu Pro  Ser Thr Arg 
    2360                 2365                 2370             


Leu Ala  Thr Gln Pro His Leu  Val Gln Thr Gln Gln  Val Gln Pro 
    2375                 2380                 2385             


Gln Asn  Leu Gln Met Gln Gln  Gln Asn Leu Gln Pro  Ala Asn Ile 
    2390                 2395                 2400             


Gln Gln  Gln Gln Ser Leu Gln  Pro Pro Pro Pro Pro  Pro Gln Pro 
    2405                 2410                 2415             


His Leu  Gly Val Ser Ser Ala  Ala Ser Gly His Leu  Gly Arg Ser 
    2420                 2425                 2430             


Phe Leu  Ser Gly Glu Pro Ser  Gln Ala Asp Val Gln  Pro Leu Gly 
    2435                 2440                 2445             


Pro Ser  Ser Leu Ala Val His  Thr Ile Leu Pro Gln  Glu Ser Pro 
    2450                 2455                 2460             


Ala Leu  Pro Thr Ser Leu Pro  Ser Ser Leu Val Pro  Pro Val Thr 
    2465                 2470                 2475             


Ala Ala  Gln Phe Leu Thr Pro  Pro Ser Gln His Ser  Tyr Ser Ser 
    2480                 2485                 2490             


Pro Val  Asp Asn Thr Pro Ser  His Gln Leu Gln Val  Pro Glu His 
    2495                 2500                 2505             


Pro Phe  Leu Thr Pro Ser Pro  Glu Ser Pro Asp Gln  Trp Ser Ser 
    2510                 2515                 2520             


Ser Ser  Pro His Ser Asn Val  Ser Asp Trp Ser Glu  Gly Val Ser 
    2525                 2530                 2535             


Ser Pro  Pro Thr Ser Met Gln  Ser Gln Ile Ala Arg  Ile Pro Glu 
    2540                 2545                 2550             


Ala Phe  Lys 
    2555     


<210>  2
<211>  2531
<212>  PRT
<213>  ˹ϳ

<400>  2

Met Pro Arg Leu Leu Thr Pro Leu Leu Cys Leu Thr Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Leu Arg Cys Ser Gln Pro Ser Gly Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Arg Cys Glu Val Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Ser Gly Ala Phe Val Gly Gln Arg Cys Gln Asp Ser Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp His Gly 
65                  70                  75                  80  


Gly Thr Val Asp Tyr Ala Cys Ser Cys Pro Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Ala Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ser 
145                 150                 155                 160 


Ser Tyr Ile Cys Arg Cys Pro Pro Gly Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Ser Gln Asn Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Ile Gly Ser Tyr Arg Cys Ala Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Thr Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Ala Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Val Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe Gln Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ala Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Leu Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Ile Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val Tyr Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly His Cys Met Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Gln Cys Pro Lys Gly Phe Asn Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Gln 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys His 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ser 
    610                 615                 620                 


Tyr Leu Cys Leu Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Asn Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Val Asn Ile Asp Glu Cys Ala Gly Ser Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Ala Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Ile His Gly Ala Cys Arg Asp Gly Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Ala Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Pro Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Thr Ser Pro Cys Lys Asn Ser Gly Val Cys Lys Glu Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Lys Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Gln 
                885                 890                 895     


Ala Gly Tyr Thr Gly Arg Asn Cys Glu Ser Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Gln Gly Ala Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asn Pro Cys Gln Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Val Gly Phe Asn 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln Tyr  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Arg Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Ser Tyr  Gly Thr Tyr Lys Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Leu Asn  Cys Gln Asn Leu Val  Arg Trp Cys Asp Ser  Ala Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Arg Cys Trp  Gln Thr Asn Thr Gln  Tyr His Cys 
    1070                 1075                 1080             


Glu Cys  Arg Ser Gly Trp Thr  Gly Val Asn Cys Asp  Val Leu Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Lys Arg Gly Ile  Asp Val Thr 
    1100                 1105                 1110             


Leu Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Glu  Gly Asp Lys 
    1115                 1120                 1125             


His Tyr  Cys His Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Glu  Val Asp Glu Cys Ser  Pro Asn Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Phe Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Ser Asn Cys  Ser Glu Glu Ile Asn  Glu Cys Leu 
    1175                 1180                 1185             


Ser Gln  Pro Cys Gln Asn Gly  Gly Thr Cys Ile Asp  Leu Thr Asn 
    1190                 1195                 1200             


Ser Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  His Pro Pro Leu Asp  Pro Ala Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Thr Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Pro 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Arg Gly Lys Pro  Cys Lys Asn Gly Gly  Val Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Arg  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Ser Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Val Gly Ser Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Asn Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Thr Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Gln Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Val Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Asn Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Leu Thr Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Leu Val Val 
    1565                 1570                 1575             


Leu Leu  Pro Pro Asp Gln Leu  Arg Asn Asn Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser His Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  Gln Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly His Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ser Thr  Val Gly Trp 
    1625                 1630                 1635             


Ala Thr  Ser Ser Leu Leu Pro  Gly Thr Ser Gly Gly  Arg Gln Arg 
    1640                 1645                 1650             


Arg Glu  Leu Asp Pro Met Asp  Ile Arg Gly Ser Ile  Val Tyr Leu 
    1655                 1660                 1665             


Glu Ile  Asp Asn Arg Gln Cys  Val Gln Ser Ser Ser  Gln Cys Phe 
    1670                 1675                 1680             


Gln Ser  Ala Thr Asp Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser 
    1685                 1690                 1695             


Leu Gly  Ser Leu Asn Ile Pro  Tyr Lys Ile Glu Ala  Val Lys Ser 
    1700                 1705                 1710             


Glu Pro  Val Glu Pro Pro Leu  Pro Ser Gln Leu His  Leu Met Tyr 
    1715                 1720                 1725             


Val Ala  Ala Ala Ala Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly 
    1730                 1735                 1740             


Val Leu  Leu Ser Arg Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp 
    1745                 1750                 1755             


Phe Pro  Glu Gly Phe Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg 
    1760                 1765                 1770             


Arg Glu  Pro Leu Gly Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys 
    1775                 1780                 1785             


Asn Ala  Ser Asp Gly Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp 
    1790                 1795                 1800             


Gly Asp  Glu Asp Leu Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro 
    1805                 1810                 1815             


Val Val  Leu Pro Asp Leu Ser  Asp Gln Thr Asp His  Arg Gln Trp 
    1820                 1825                 1830             


Thr Gln  Gln His Leu Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met 
    1835                 1840                 1845             


Ala Pro  Thr Pro Pro Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp 
    1850                 1855                 1860             


Val Asn  Val Arg Gly Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala 
    1865                 1870                 1875             


Ser Cys  Ser Gly Gly Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu 
    1880                 1885                 1890             


Glu Asp  Ala Pro Ala Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala 
    1895                 1900                 1905             


Ser Leu  His Asn Gln Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His 
    1910                 1915                 1920             


Leu Ala  Ala Arg Tyr Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu 
    1925                 1930                 1935             


Glu Ala  Ser Ala Asp Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr 
    1940                 1945                 1950             


Pro Leu  His Ala Ala Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln 
    1955                 1960                 1965             


Ile Leu  Leu Arg Asn Arg Ala  Thr Asp Leu Asp Ala  Arg Met His 
    1970                 1975                 1980             


Asp Gly  Thr Thr Pro Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu 
    1985                 1990                 1995             


Gly Met  Leu Glu Asp Leu Ile  Asn Ser His Ala Asp  Val Asn Ala 
    2000                 2005                 2010             


Val Asp  Asp Leu Gly Lys Ser  Ala Leu His Trp Ala  Ala Ala Val 
    2015                 2020                 2025             


Asn Asn  Val Asp Ala Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn 
    2030                 2035                 2040             


Lys Asp  Met Gln Asn Asn Lys  Glu Glu Thr Pro Leu  Phe Leu Ala 
    2045                 2050                 2055             


Ala Arg  Glu Gly Ser Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His 
    2060                 2065                 2070             


Phe Ala  Asn Arg Asp Ile Thr  Asp His Met Asp Arg  Leu Pro Arg 
    2075                 2080                 2085             


Asp Ile  Ala Gln Glu Arg Met  His His Asp Ile Val  Arg Leu Leu 
    2090                 2095                 2100             


Asp Glu  Tyr Asn Leu Val Arg  Ser Pro Gln Leu His  Gly Thr Ala 
    2105                 2110                 2115             


Leu Gly  Gly Thr Pro Thr Leu  Ser Pro Thr Leu Cys  Ser Pro Asn 
    2120                 2125                 2130             


Gly Tyr  Leu Gly Asn Leu Lys  Ser Ala Thr Gln Gly  Lys Lys Ala 
    2135                 2140                 2145             


Arg Lys  Pro Ser Thr Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala 
    2150                 2155                 2160             


Lys Asp  Leu Lys Ala Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly 
    2165                 2170                 2175             


Cys Leu  Leu Asp Ser Ser Ser  Met Leu Ser Pro Val  Asp Ser Leu 
    2180                 2185                 2190             


Glu Ser  Pro His Gly Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu 
    2195                 2200                 2205             


Leu Pro  Ser Pro Phe Gln Gln  Ser Pro Ser Met Pro  Leu Ser His 
    2210                 2215                 2220             


Leu Pro  Gly Met Pro Asp Thr  His Leu Gly Ile Ser  His Leu Asn 
    2225                 2230                 2235             


Val Ala  Ala Lys Pro Glu Met  Ala Ala Leu Ala Gly  Gly Ser Arg 
    2240                 2245                 2250             


Leu Ala  Phe Glu Pro Pro Pro  Pro Arg Leu Ser His  Leu Pro Val 
    2255                 2260                 2265             


Ala Ser  Ser Ala Ser Thr Val  Leu Ser Thr Asn Gly  Thr Gly Ala 
    2270                 2275                 2280             


Met Asn  Phe Thr Val Gly Ala  Pro Ala Ser Leu Asn  Gly Gln Cys 
    2285                 2290                 2295             


Glu Trp  Leu Pro Arg Leu Gln  Asn Gly Met Val Pro  Ser Gln Tyr 
    2300                 2305                 2310             


Asn Pro  Leu Arg Pro Gly Val  Thr Pro Gly Thr Leu  Ser Thr Gln 
    2315                 2320                 2325             


Ala Ala  Gly Leu Gln His Ser  Met Met Gly Pro Leu  His Ser Ser 
    2330                 2335                 2340             


Leu Ser  Thr Asn Thr Leu Ser  Pro Ile Ile Tyr Gln  Gly Leu Pro 
    2345                 2350                 2355             


Asn Thr  Arg Leu Ala Thr Gln  Pro His Leu Val Gln  Thr Gln Gln 
    2360                 2365                 2370             


Val Gln  Pro Gln Asn Leu Gln  Leu Gln Pro Gln Asn  Leu Gln Pro 
    2375                 2380                 2385             


Pro Ser  Gln Pro His Leu Ser  Val Ser Ser Ala Ala  Asn Gly His 
    2390                 2395                 2400             


Leu Gly  Arg Ser Phe Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val 
    2405                 2410                 2415             


Gln Pro  Leu Gly Pro Ser Ser  Leu Pro Val His Thr  Ile Leu Pro 
    2420                 2425                 2430             


Gln Glu  Ser Gln Ala Leu Pro  Thr Ser Leu Pro Ser  Ser Met Val 
    2435                 2440                 2445             


Pro Pro  Met Thr Thr Thr Gln  Phe Leu Thr Pro Pro  Ser Gln His 
    2450                 2455                 2460             


Ser Tyr  Ser Ser Ser Pro Val  Asp Asn Thr Pro Ser  His Gln Leu 
    2465                 2470                 2475             


Gln Val  Pro Glu His Pro Phe  Leu Thr Pro Ser Pro  Glu Ser Pro 
    2480                 2485                 2490             


Asp Gln  Trp Ser Ser Ser Ser  Pro His Ser Asn Ile  Ser Asp Trp 
    2495                 2500                 2505             


Ser Glu  Gly Ile Ser Ser Pro  Pro Thr Thr Met Pro  Ser Gln Ile 
    2510                 2515                 2520             


Thr His  Ile Pro Glu Ala Phe  Lys 
    2525                 2530     


<210>  3
<211>  316
<212>  DNA
<213>  ˹ϳ

<400>  3
ggcgatctga cggttcacta aacgagctct gcttatatag gcctcccacc gtacacgcct     60

acctcgacat acgttctcta tcactgatag ggagtaaact cgacatacgt tctctatcac    120

tgatagggat aaactcgaca tacgttctct atcactgata gggagtaaac tcgacatacg    180

ttctctatca ctgataggga gtaaactcga catacgttct ctatcactga tagggagtaa    240

actcgacatc gttctctatc actgataggg agtaaactcg acatacgttc tctatcactg    300

atagggagta aactcg                                                    316


<210>  4
<211>  199
<212>  PRT
<213>  ˹ϳ

<400>  4

Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 
1               5                   10                  15      


Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 
            20                  25                  30          


Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 
        35                  40                  45              


Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 
    50                  55                  60                  


Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 
65                  70                  75                  80  


Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 
                85                  90                  95      


Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 
            100                 105                 110         


Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 
        115                 120                 125             


Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 
    130                 135                 140                 


Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu 
145                 150                 155                 160 


Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe 
                165                 170                 175     


Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys 
            180                 185                 190         


Met Thr Arg Lys Pro Gly Ala 
        195                 


<210>  5
<211>  18
<212>  PRT
<213>  ˹ϳ

<400>  5

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  6
<211>  239
<212>  PRT
<213>  ˹ϳ

<400>  6

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  7
<211>  236
<212>  PRT
<213>  ˹ϳ

<400>  7

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210>  8
<211>  189
<212>  DNA
<213>  ˹ϳ

<400>  8
ggatcataat cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac     60

acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg    120

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt    180

tttcactgc                                                            189


<210>  9
<211>  1265
<212>  DNA
<213>  ˹ϳ

<400>  9
aagctttgca aagatggata aagttttaaa cagagaggaa tctttgcagc taatggacct     60

tctaggtctt gaaaggagtg ggaattggct ccggtgcccg tcagtgggca gagcgcacat    120

cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa    180

ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg    240

gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt    300

ttgccgccag aacacaggta agtgccgtgt gtggttcccg cgggcctggc ctctttacgg    360

gttatggccc ttgcgtgcct tgaattactt ccacctggct gcagtacgtg attcttgatc    420

ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa ggagcccctt    480

cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg cgaatctggt    540

ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa aatttttgat    600

gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc caagatctgc    660

acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg tcccagcgca    720

catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc    780

aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg    840

cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg cttcccggcc    900

ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac    960

ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac tccacggagt   1020

accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg tcgtctttag   1080

gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg gagactgaag   1140

ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt gagtttggat   1200

cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca tttcaggtgt   1260

cgtga                                                               1265


<210>  10
<211>  248
<212>  PRT
<213>  ˹ϳ

<400>  10

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro 
        195                 200                 205             


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
    210                 215                 220                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp 
225                 230                 235                 240 


Phe Asp Leu Asp Met Leu Pro Gly 
                245             


<210>  11
<211>  501
<212>  DNA
<213>  ˹ϳ

<400>  11
gggtagggga ggcgcttttc ccaaggcagt ctggagcatg cgctttagca gccccgctgg     60

gcacttggcg ctacacaagt ggcctctggc ctcgcacaca ttccacatcc accggtaggc    120

gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct cccctagtca    180

ggaagttccc ccccgccccg cagctcgcgt cgtgcaggac gtgacaaatg gaagtagcac    240

gtctcactag tctcgtgcag atggacagca ccgctgagca atggaagcgg gtaggccttt    300

ggggcagcgg ccaatagcag ctttgctcct tcgctttctg ggctcagagg ctgggaaggg    360

gtgggtccgg gggcgggctc aggggcgggc tcaggggcgg ggcgggcgcc cgaaggtcct    420

ccggaggccc ggcattctgc acgcttcaaa agcgcacgtc tgccgcgctg ttctcctctt    480

cctcatctcc gggcctttcg a                                              501


<210>  12
<211>  19
<212>  PRT
<213>  ˹ϳ

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala 
            


<210>  13
<211>  242
<212>  PRT
<213>  ˹ϳ

<400>  13

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  14
<211>  243
<212>  PRT
<213>  ˹ϳ

<400>  14

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
145                 150                 155                 160 


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                165                 170                 175     


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
            180                 185                 190         


Lys Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  15
<211>  557
<212>  PRT
<213>  ˹ϳ

<400>  15

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Ala 
                485                 490                 495     


Gly Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro 
            500                 505                 510         


Gln Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp 
        515                 520                 525             


Ala Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala 
    530                 535                 540                 


Trp Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555         


<210>  16
<211>  603
<212>  PRT
<213>  ˹ϳ

<400>  16

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Glu Thr Glu Lys Lys Ile Trp His 
            340                 345                 350         


Phe Lys Tyr Pro Ile Phe Phe Leu Cys Ile Gly Leu Asp Leu Gln Ile 
        355                 360                 365             


Gly Lys Leu Cys Ala His Ser Gln Gln Arg Gln Tyr Arg Ser Ala Tyr 
    370                 375                 380                 


Tyr Pro Glu Asp Leu Phe Ile Asp Lys Lys Val Leu Lys Val Ala His 
385                 390                 395                 400 


Val Glu His Glu Glu Thr Leu Ser Ser Arg Arg Arg Glu Leu Ile Gln 
                405                 410                 415     


Lys Leu Lys Ser Phe Ile Ser Phe Tyr Ser Ala Leu Pro Gly Tyr Ile 
            420                 425                 430         


Cys Ser His Ser Pro Val Ala Glu Asn Asp Thr Leu Cys Trp Asn Gly 
        435                 440                 445             


Gln Glu Leu Val Glu Arg Tyr Ser Gln Lys Ala Ala Arg Asn Gly Met 
    450                 455                 460                 


Lys Asn Gln Phe Asn Leu His Glu Leu Lys Met Lys Gly Pro Glu Pro 
465                 470                 475                 480 


Val Val Ser Gln Ile Ile Asp Lys Leu Lys His Ile Asn Gln Leu Leu 
                485                 490                 495     


Arg Thr Met Ser Met Pro Lys Gly Arg Val Leu Asp Lys Asn Leu Asp 
            500                 505                 510         


Glu Glu Gly Phe Glu Ser Gly Asp Cys Gly Asp Asp Glu Asp Glu Cys 
        515                 520                 525             


Ile Gly Gly Ser Gly Asp Gly Met Ile Lys Val Lys Asn Gln Leu Arg 
    530                 535                 540                 


Phe Leu Ala Glu Leu Ala Tyr Asp Leu Asp Val Asp Asp Ala Pro Gly 
545                 550                 555                 560 


Asn Ser Gln Gln Ala Thr Pro Lys Asp Asn Glu Ile Ser Thr Phe His 
                565                 570                 575     


Asn Leu Gly Asn Val His Ser Pro Leu Lys Leu Leu Thr Ser Met Ala 
            580                 585                 590         


Ile Ser Val Val Cys Phe Phe Phe Leu Val His 
        595                 600             


<210>  17
<211>  233
<212>  PRT
<213>  ˹ϳ

<400>  17

Met Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
1               5                   10                  15      


Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
            20                  25                  30          


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly 
        35                  40                  45              


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr 
    50                  55                  60                  


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
65                  70                  75                  80  


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
                85                  90                  95      


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
            100                 105                 110         


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 
        115                 120                 125             


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
    210                 215                 220                 


Pro Ser Lys Leu Gly His Lys Leu Asn 
225                 230             


<210>  18
<211>  17
<212>  DNA
<213>  ˹ϳ

<400>  18
agtggcctca caggtat                                                    17


<210>  19
<211>  16
<212>  DNA
<213>  ˹ϳ

<400>  19
acagtcactg agctgc                                                     16


<210>  20
<211>  50
<212>  PRT
<213>  ˹ϳ

<400>  20

Asn Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser 
1               5                   10                  15      


Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val 
            20                  25                  30          


Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys 
        35                  40                  45              


Pro Arg 
    50  


<210>  21
<211>  395
<212>  PRT
<213>  ˹ϳ

<400>  21

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly 
            100                 105                 110         


Ser Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala 
        115                 120                 125             


Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile 
    130                 135                 140                 


Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr 
145                 150                 155                 160 


Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu 
                165                 170                 175     


His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val 
            180                 185                 190         


Leu Ala Leu Leu Glu Leu Ala Arg Gln Asp His Gly Ala Leu Asp Cys 
        195                 200                 205             


Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln 
    210                 215                 220                 


Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu 
225                 230                 235                 240 


Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly 
                245                 250                 255     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp 
            260                 265                 270         


His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly 
        275                 280                 285             


Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr 
    290                 295                 300                 


Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile 
305                 310                 315                 320 


Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro 
                325                 330                 335     


Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln 
            340                 345                 350         


Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn 
        355                 360                 365             


Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn 
    370                 375                 380                 


Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
385                 390                 395 


<210>  22
<211>  256
<212>  DNA
<213>  ˹ϳ

<400>  22
taggtcttga aaggagtggg aattggctcc ggtgcccgtc agtgggcaga gcgcacatcg     60

cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gatccggtgc ctagagaagg    120

tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt    180

gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt    240

gccgccagaa cacagg                                                    256


<210>  23
<211>  132
<212>  PRT
<213>  ˹ϳ

<400>  23

Met Ala Lys Pro Leu Ser Gln Glu Glu Ser Thr Leu Ile Glu Arg Ala 
1               5                   10                  15      


Thr Ala Thr Ile Asn Ser Ile Pro Ile Ser Glu Asp Tyr Ser Val Ala 
            20                  25                  30          


Ser Ala Ala Leu Ser Ser Asp Gly Arg Ile Phe Thr Gly Val Asn Val 
        35                  40                  45              


Tyr His Phe Thr Gly Gly Pro Cys Ala Glu Leu Val Val Leu Gly Thr 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Gly Asn Leu Thr Cys Ile Val Ala Ile Gly 
65                  70                  75                  80  


Asn Glu Asn Arg Gly Ile Leu Ser Pro Cys Gly Arg Cys Arg Gln Val 
                85                  90                  95      


Leu Leu Asp Leu His Pro Gly Ile Lys Ala Ile Val Lys Asp Ser Asp 
            100                 105                 110         


Gly Gln Pro Thr Ala Val Gly Ile Arg Glu Leu Leu Pro Ser Gly Tyr 
        115                 120                 125             


Val Trp Glu Gly 
    130         


<210>  24
<211>  21
<212>  DNA
<213>  ˹ϳ

<400>  24
gcattctgca cgcttcaaaa g                                               21


<210>  25
<211>  22
<212>  DNA
<213>  ˹ϳ

<400>  25
gaagctgtag tccaggatgt gg                                              22


<210>  26
<211>  227
<212>  PRT
<213>  ˹ϳ

<400>  26

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


