                         SEQUENCE LISTING

<110>  Rhode Island Hospital
 
<120>  Inhibition of ASPH Expressing Tumor Growth and Progression

<130>  21486-642001WO

<150>  62/779,422
<151>  2018-12-13

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p52

<400>  1

Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu Gly Val Trp 
1               5                   10                  15      


Thr Ser Val Ala 
            20  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p103

<400>  2

Ala Lys Val Leu Leu Gly Leu Lys Glu Arg Ser Thr Ser Glu Pro 
1               5                   10                  15  


<210>  3
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p148

<400>  3

Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His Ala Glu His 
1               5                   10                  15      


Val Glu Gly 
            


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p322

<400>  4

Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys Phe 
1               5                   10                  15      


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p415

<400>  5

Pro Ala Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln 
1               5                   10                  15      


Gln Phe 
        


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p427

<400>  6

Ser Asp Arg Gln Gln Phe Leu Gly His Met Arg Gly Ser Leu Leu Thr 
1               5                   10                  15      


Leu Gln 
        


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p437

<400>  7

Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln Leu Phe Pro Asn 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p443

<400>  8

Leu Gln Arg Leu Val Gln Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn 
1               5                   10                  15      


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p492

<400>  9

Val His Tyr Gly Phe Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser 
1               5                   10                  15      


Ile Pro 
        


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p557

<400>  10

Ala Ser Val Trp Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala 
1               5                   10                  15      


Gln Pro Trp Trp 
            20  


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p58

<400>  11

Thr Gly Tyr Thr Glu Leu Val Lys Ser Leu Glu Arg Asn Trp Lys Leu 
1               5                   10                  15      


Ile 
    


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p588

<400>  12

Lys Ser Leu Glu Arg Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala 
1               5                   10                  15      


Val Met Asp Lys 
            20  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p725

<400>  13

His Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu Ile Phe 
1               5                   10                  


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p731

<400>  14

Ala Ser Ser Phe Arg Leu Ile Phe Ile Val Asp Val Trp His Pro Glu 
1               5                   10                  15      


Leu 
    


<210>  15
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VDVWHPELTPQQRRSLPAI

<400>  15

Val Asp Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg Arg Ser Leu 
1               5                   10                  15      


Pro Ala Ile 
            


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH48

<400>  16

Gly Leu Ser Gly Thr Ser Phe Phe Thr 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH53

<400>  17

Ser Phe Phe Thr Trp Phe Met Val Ile 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH58

<400>  18

Phe Met Val Ile Ala Leu Leu Gly Val 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH62

<400>  19

Ala Leu Leu Gly Val Trp Thr Ser Val 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH72

<400>  20

Val Val Trp Phe Asp Leu Val Asp Tyr 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH79

<400>  21

Asp Tyr Glu Glu Val Leu Gly Lys Leu 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH81

<400>  22

Glu Glu Val Leu Gly Lys Leu Gly Ile 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH252

<400>  23

Thr Asp Asp Val Thr Tyr Gln Val Tyr 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH258

<400>  24

Gln Val Tyr Glu Glu Gln Ala Val Tyr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH261

<400>  25

Glu Glu Gln Ala Val Tyr Glu Pro Leu 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH371

<400>  26

Tyr Pro Gln Ser Pro Arg Ala Arg Tyr 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH374

<400>  27

Ser Pro Arg Ala Arg Tyr Gly Lys Ala 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH406

<400>  28

Gln Glu Val Ala Ser Leu Pro Asp Val 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH411

<400>  29

Leu Pro Asp Val Pro Ala Asp Leu Leu 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH475

<400>  30

Lys Val Tyr Glu Glu Val Leu Ser Val 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH478

<400>  31

Glu Glu Val Leu Ser Val Thr Pro Asn 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH484

<400>  32

Thr Pro Asn Asp Gly Phe Ala Lys Val 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH488

<400>  33

Gly Phe Ala Lys Val His Tyr Gly Phe 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH491

<400>  34

Lys Val His Tyr Gly Phe Ile Leu Lys 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH503

<400>  35

Lys Ile Ala Glu Ser Ile Pro Tyr Leu 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH521

<400>  36

Gly Thr Asp Asp Gly Arg Phe Tyr Phe 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH537

<400>  37

Arg Val Gly Asn Lys Glu Ala Tyr Lys 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH557

<400>  38

Ala Ser Val Trp Gln Arg Ser Leu Tyr 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH563

<400>  39

Ser Leu Tyr Asn Val Asn Gly Leu Lys 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH582

<400>  40

Gly Tyr Thr Glu Leu Val Lys Ser Leu 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH611

<400>  41

Leu Phe Leu Pro Glu Asp Glu Asn Leu 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH681

<400>  42

Gly Pro Thr Asn Cys Arg Leu Arg Met 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH693

<400>  43

Leu Val Ile Pro Lys Glu Gly Cys Lys 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH701

<400>  44

Lys Ile Arg Cys Ala Asn Glu Thr Arg 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASPH711

<400>  45

Trp Glu Glu Gly Lys Val Leu Ile Phe 
1               5                   


<210>  46
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala 
            20                  25                  30          


Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly 
        35                  40                  45              


Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu 
    50                  55                  60                  


Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr 
65                  70                  75                  80  


Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly 
                85                  90                  95      


Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg 
            100                 105                 110         


Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr 
        115                 120                 125             


Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu 
    130                 135                 140                 


Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His 
145                 150                 155                 160 


Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr 
                165                 170                 175     


Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val 
            180                 185                 190         


Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr 
        195                 200                 205             


Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln 
    210                 215                 220                 


Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu 
225                 230                 235                 240 


Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp Asp Val Thr 
                245                 250                 255     


Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu Glu Asn Glu 
            260                 265                 270         


Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp Asn Pro Val 
        275                 280                 285             


Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe Pro Val Glu 
    290                 295                 300                 


Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr Asp Asp Pro 
305                 310                 315                 320 


Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys 
                325                 330                 335     


Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu Lys Leu Arg 
            340                 345                 350         


Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys Glu Leu Val 
        355                 360                 365             


Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys Ala Gln Cys 
    370                 375                 380                 


Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val Leu Arg Gly 
385                 390                 395                 400 


Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp Val Pro Ala 
                405                 410                 415     


Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln Gln Phe 
            420                 425                 430         


Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln 
        435                 440                 445             


Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly Val Gly Tyr 
    450                 455                 460                 


Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr Glu Glu Val 
465                 470                 475                 480 


Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His Tyr Gly Phe 
                485                 490                 495     


Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro Tyr Leu Lys 
            500                 505                 510         


Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly Arg Phe Tyr 
        515                 520                 525             


Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys Glu Ala Tyr 
    530                 535                 540                 


Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala Ser Val Trp 
545                 550                 555                 560 


Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln Pro Trp Trp 
                565                 570                 575     


Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser Leu Glu Arg 
            580                 585                 590         


Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met Asp Lys Ala 
        595                 600                 605             


Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu Lys Gly Asp 
    610                 615                 620                 


Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn Glu Asn Ala 
625                 630                 635                 640 


Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys Phe Pro Glu 
                645                 650                 655     


Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile Met His Pro 
            660                 665                 670         


Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys Arg Leu Arg 
        675                 680                 685             


Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys Ile Arg Cys 
    690                 695                 700                 


Ala Asn Glu Thr Arg Thr Trp Glu Glu Gly Lys Val Leu Ile Phe Asp 
705                 710                 715                 720 


Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu 
                725                 730                 735     


Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg 
            740                 745                 750         


Arg Ser Leu Pro Ala Ile 
        755             


<210>  47
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the first third of the human ASPH amino acid sequence

<400>  47

Met Ala Gln Arg Lys Asn Ala Lys Ser Ser Gly Asn Ser Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Thr Ser Ala Gly Ser Ser Ser Pro Gly Ala 
            20                  25                  30          


Arg Arg Glu Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly 
        35                  40                  45              


Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu 
    50                  55                  60                  


Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr 
65                  70                  75                  80  


Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly 
                85                  90                  95      


Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu Lys Glu Arg 
            100                 105                 110         


Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu Pro His Thr 
        115                 120                 125             


Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln Asn Ile Glu 
    130                 135                 140                 


Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu Met Val His 
145                 150                 155                 160 


Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr 
                165                 170                 175     


Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val 
            180                 185                 190         


Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His Glu Glu Thr 
        195                 200                 205             


Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp Cys Asn Gln 
    210                 215                 220                 


Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp Ser Ser Glu 
225                 230                 235                 240 


Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp 
                245                 250             


<210>  48
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the last third of the human ASPH amino acid sequence

<400>  48

Glu Ser Ile Pro Tyr Leu Lys Glu Gly Ile Glu Ser Gly Asp Pro Gly 
1               5                   10                  15      


Thr Asp Asp Gly Arg Phe Tyr Phe His Leu Gly Asp Ala Met Gln Arg 
            20                  25                  30          


Val Gly Asn Lys Glu Ala Tyr Lys Trp Tyr Glu Leu Gly His Lys Arg 
        35                  40                  45              


Gly His Phe Ala Ser Val Trp Gln Arg Ser Leu Tyr Asn Val Asn Gly 
    50                  55                  60                  


Leu Lys Ala Gln Pro Trp Trp Thr Pro Lys Glu Thr Gly Tyr Thr Glu 
65                  70                  75                  80  


Leu Val Lys Ser Leu Glu Arg Asn Trp Lys Leu Ile Arg Asp Glu Gly 
                85                  90                  95      


Leu Ala Val Met Asp Lys Ala Lys Gly Leu Phe Leu Pro Glu Asp Glu 
            100                 105                 110         


Asn Leu Arg Glu Lys Gly Asp Trp Ser Gln Phe Thr Leu Trp Gln Gln 
        115                 120                 125             


Gly Arg Arg Asn Glu Asn Ala Cys Lys Gly Ala Pro Lys Thr Cys Thr 
    130                 135                 140                 


Leu Leu Glu Lys Phe Pro Glu Thr Thr Gly Cys Arg Arg Gly Gln Ile 
145                 150                 155                 160 


Lys Tyr Ser Ile Met His Pro Gly Thr His Val Trp Pro His Thr Gly 
                165                 170                 175     


Pro Thr Asn Cys Arg Leu Arg Met His Leu Gly Leu Val Ile Pro Lys 
            180                 185                 190         


Glu Gly Cys Lys Ile Arg Cys Ala Asn Glu Thr Arg Thr Trp Glu Glu 
        195                 200                 205             


Gly Lys Val Leu Ile Phe Asp Asp Ser Phe Glu His Glu Val Trp Gln 
    210                 215                 220                 


Asp Ala Ser Ser Phe Arg Leu Ile Phe Ile Val Asp Val Trp His Pro 
225                 230                 235                 240 


Glu Leu Thr Pro Gln Gln Arg Arg Ser Leu Pro Ala Ile 
                245                 250             


<210>  49
<211>  2324
<212>  DNA
<213>  Homo sapiens

<400>  49
cggaccgtgc aatggcccag cgtaagaatg ccaagagcag cggcaacagc agcagcagcg       60

gctccggcag cggtagcacg agtgcgggca gcagcagccc cggggcccgg agagagacaa      120

agcatggagg acacaagaat gggaggaaag gcggactctc gggaacttca ttcttcacgt      180

ggtttatggt gattgcattg ctgggcgtct ggacatctgt agctgtcgtt tggtttgatc      240

ttgttgacta tgaggaagtt ctaggaaaac taggaatcta tgatgctgat ggtgatggag      300

attttgatgt ggatgatgcc aaagttttat taggacttaa agagagatct acttcagagc      360

cagcagtccc gccagaagag gctgagccac acactgagcc cgaggagcag gttcctgtgg      420

aggcagaacc ccagaatatc gaagatgaag caaaagaaca aattcagtcc cttctccatg      480

aaatggtaca cgcagaacat gttgagggag aagacttgca acaagaagat ggacccacag      540

gagaaccaca acaagaggat gatgagtttc ttatggcgac tgatgtagat gatagatttg      600

agaccctgga acctgaagta tctcatgaag aaaccgagca tagttaccac gtggaagaga      660

cagtttcaca agactgtaat caggatatgg aagagatgat gtctgagcag gaaaatccag      720

attccagtga accagtagta gaagatgaaa gattgcacca tgatacagat gatgtaacat      780

accaagtcta tgaggaacaa gcagtatatg aacctctaga aaatgaaggg atagaaatca      840

cagaagtaac tgctccccct gaggataatc ctgtagaaga ttcacaggta attgtagaag      900

aagtaagcat ttttcctgtg gaagaacagc aggaagtacc accagaaaca aatagaaaaa      960

cagatgatcc agaacaaaaa gcaaaagtta agaaaaagaa gcctaaactt ttaaataaat     1020

ttgataagac tattaaagct gaacttgatg ctgcagaaaa actccgtaaa aggggaaaaa     1080

ttgaggaagc agtgaatgca tttaaagaac tagtacgcaa ataccctcag agtccacgag     1140

caagatatgg gaaggcgcag tgtgaggatg atttggctga gaagaggaga agtaatgagg     1200

tgctacgtgg agccatcgag acctaccaag aggtggccag cctacctgat gtccctgcag     1260

acctgctgaa gctgagtttg aagcgtcgct cagacaggca acaatttcta ggtcatatga     1320

gaggttccct gcttaccctg cagagattag ttcaactatt tcccaatgat acttccttaa     1380

aaaatgacct tggcgtggga tacctcttga taggagataa tgacaatgca aagaaagttt     1440

atgaagaggt gctgagtgtg acacctaatg atggctttgc taaagtccat tatggcttca     1500

tcctgaaggc acagaacaaa attgctgaga gcatcccata tttaaaggaa ggaatagaat     1560

ccggagatcc tggcactgat gatgggagat tttatttcca cctgggggat gccatgcaga     1620

gggttgggaa caaagaggca tataagtggt atgagcttgg gcacaagaga ggacactttg     1680

catctgtctg gcaacgctca ctctacaatg tgaatggact gaaagcacag ccttggtgga     1740

ccccaaaaga aacgggctac acagagttag taaagtcttt agaaagaaac tggaagttaa     1800

tccgagatga aggccttgca gtgatggata aagccaaagg tctcttcctg cctgaggatg     1860

aaaacctgag ggaaaaaggg gactggagcc agttcacgct gtggcagcaa ggaagaagaa     1920

atgaaaatgc ctgcaaagga gctcctaaaa cctgtacctt actagaaaag ttccccgaga     1980

caacaggatg cagaagagga cagatcaaat attccatcat gcaccccggg actcacgtgt     2040

ggccgcacac agggcccaca aactgcaggc tccgaatgca cctgggcttg gtgattccca     2100

aggaaggctg caagattcga tgtgccaacg agaccaggac ctgggaggaa ggcaaggtgc     2160

tcatctttga tgactccttt gagcacgagg tatggcagga tgcctcatct ttccggctga     2220

tattcatcgt ggatgtgtgg catccggaac tgacaccaca gcagagacgc agccttccag     2280

caatttagca tgaattcatg caagcttggg aaactctgga gaga                      2324


