                         SEQUENCE LISTING

<110>  Pioneer Hi-Bred International, Inc.
 
<120>  NOVEL CRISPR-CAS SYSTEMS FOR GENOME EDITING

<130>  RTS21920B

<150>  62/779989
<151>  2018-12-14

<150>  62/794427
<151>  2019-01-18

<150>  62/819409
<151>  2019-03-15

<150>  62/852788
<151>  2019-05-24

<150>  62/913492
<151>  2019-10-10

<160>  371   

<170>  PatentIn version 3.5

<210>  1
<211>  327
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  1

Met Gln Leu Ile Ile Asp Asp Tyr Gly Ala Tyr Leu Gly Gln Lys Asp 
1               5                   10                  15      


Asn Leu Phe Gln Ile Arg Lys Lys Asp Gly Thr Cys Glu Glu Tyr Ser 
            20                  25                  30          


Ala Asp Lys Val Glu Gln Ile Leu Leu Val Lys Asn Ser Cys Ile Ser 
        35                  40                  45              


Ser Arg Ala Ala Leu Leu Ala Ala Arg Asn Asn Ile Asp Val Val Phe 
    50                  55                  60                  


Val Gly Lys Phe Gly Met Pro Glu Gly Arg Ile Phe Pro Ala Cys Leu 
65                  70                  75                  80  


Gly Gly Thr Asn Leu Ile Arg Arg Lys Gln Leu Glu Ala Gly Gln Asn 
                85                  90                  95      


Glu Lys Gly Gly Lys Ile Ala Ile Lys Leu Ile Trp Ala Lys Ile Lys 
            100                 105                 110         


Asn Glu Glu Phe Phe Leu Lys Thr Leu Asn Lys Ser Arg Thr Ala Pro 
        115                 120                 125             


Leu Leu Leu Glu Lys Ala Glu Lys Ile Ser Ala Ile Ala Glu Gln Val 
    130                 135                 140                 


Arg Gln Met Leu Gly Glu Lys Phe Asp Ala Asp Arg Val Phe Gly Phe 
145                 150                 155                 160 


Glu Gly Leu Ala Ala Ala His Tyr Phe Glu Gly Leu Ser Gln Val Met 
                165                 170                 175     


Pro Ile Glu Lys Arg Asp Gln Glu Gly Lys Asp Ala Pro Asn Ala Leu 
            180                 185                 190         


Leu Asn Tyr Gly Tyr Gly Met Leu Tyr Gly Glu Ile Glu Lys Ala Cys 
        195                 200                 205             


Leu Phe Ala Gly Leu Asp Pro Tyr Leu Gly Phe Leu His Ala Asp Arg 
    210                 215                 220                 


Tyr Gly Lys Pro Ser Leu Val Leu Asp Leu Ile Glu Glu Phe Arg Pro 
225                 230                 235                 240 


Val Ile Val Asp Arg Ala Ile Ile Thr Leu Tyr Ala Gln Lys Gln Ile 
                245                 250                 255     


Asn Glu Ser Asp Phe Glu Gln Gly Gly Asp Lys Ile Phe Leu Ser Lys 
            260                 265                 270         


Glu Gly Arg Lys Lys Met Ile Lys Ala Ile Met Glu Arg Leu His Ala 
        275                 280                 285             


Lys Ile Thr Ser Asp Gly Arg Lys Leu Glu Leu Ser Val Ile Ile Gln 
    290                 295                 300                 


Glu Gln Ala Arg Arg Ile Ala Ser Phe Val Lys Gly Glu Ser Glu Phe 
305                 310                 315                 320 


Glu Pro Phe Leu Tyr Arg Trp 
                325         


<210>  2
<211>  329
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  2

Met Ile Leu Val Ile Asn Asp Phe Ser Thr Phe Leu Gly Lys Lys Gly 
1               5                   10                  15      


Asp Arg Phe Val Ile Lys Lys Glu Asn Lys Arg Glu Glu Phe Ser Thr 
            20                  25                  30          


Asn Asn Val Glu Gln Ile Ile Ile Ala Ala Val Ser Ser Ile Ser Tyr 
        35                  40                  45              


Gly Ala Ile Arg Leu Ala Ile Lys His Ser Ile Asp Val Val Phe Leu 
    50                  55                  60                  


Ser Arg Gly Gly Thr Pro Leu Gly Arg Ile Tyr Pro Cys Lys Leu Gly 
65                  70                  75                  80  


Gly Thr Thr Leu Thr Arg Lys Lys Gln Leu Glu Ala Tyr Tyr Ser Thr 
                85                  90                  95      


Val Gly Thr Asn Ile Val Lys Asn Leu Val Lys Ala Lys Ile Met Asn 
            100                 105                 110         


Gln Ala Tyr Phe Leu Lys Ser Leu Glu Lys Thr Arg Lys Asp Ile Asn 
        115                 120                 125             


Phe Thr Ser Glu Ile Asn Ser Ile Val Asn Ile Ala Lys Lys Ile Pro 
    130                 135                 140                 


Gly Leu Thr Gly Leu Ile Asp Asp Ile Arg Gly Thr Leu Leu Gly Tyr 
145                 150                 155                 160 


Glu Gly Ile Ala Ala Asn Lys Tyr Phe Ser Ser Leu Ser Asn Ile Leu 
                165                 170                 175     


Pro Phe Lys Gly Arg Asp Arg Thr Ser Asn Asp Tyr Val Asn Ile Val 
            180                 185                 190         


Leu Asn Tyr Gly Tyr Gly Val Leu Tyr Thr Glu Ala Glu Lys Ala Cys 
        195                 200                 205             


Ile Leu Ala Gly Leu Asp Pro Tyr Phe Gly Phe Leu His Lys Asp Arg 
    210                 215                 220                 


Tyr Asn Lys Pro Ser Met Val Leu Asp Leu Val Glu Ile Phe Arg Pro 
225                 230                 235                 240 


Ile Ile Val Asp Arg Ala Val Val Thr Leu Phe Ser Gln Lys Gln Ile 
                245                 250                 255     


Asn Ser Lys Cys Phe Glu Lys Glu Thr Tyr Gly Asp Val Phe Leu Ser 
            260                 265                 270         


Lys Glu Gly Arg Glu Lys Ile Leu Ser Ala Leu Leu Ser Arg Leu Asn 
        275                 280                 285             


Gln Gln Ile Arg Phe Lys Gly Lys Lys Thr Ser Phe Lys Asn Ile Ile 
    290                 295                 300                 


Leu Gly Glu Ser Arg Ser Ile Ala Gln Tyr Val Leu Gly Asn Ile Pro 
305                 310                 315                 320 


Glu Tyr Glu Pro Phe Val Tyr Arg Trp 
                325                 


<210>  3
<211>  326
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Aureabacteria bacterium

<400>  3

Met Gln Leu Val Ile Asp Asp Phe Gly Thr Phe Val Lys Lys Lys Gln 
1               5                   10                  15      


Asn Arg Phe Glu Val Ala Arg Lys Glu Lys Thr Glu Glu Phe Ser Ala 
            20                  25                  30          


Asp Lys Val Ser Gln Ile Val Leu Leu Lys Lys Gly Thr Ile Ser Gly 
        35                  40                  45              


Ser Ala Val Ala Leu Ala Met Glu Lys Asn Ile Asp Val Val Tyr Leu 
    50                  55                  60                  


Asp Ser Phe Gly Lys Pro Ile Ala Arg Ile Phe Pro Cys Thr Leu Gly 
65                  70                  75                  80  


Gly Thr Thr Leu Ile Arg Arg Arg Gln Ala Glu Ala Thr Ala Ser Leu 
                85                  90                  95      


Tyr Ala Val Pro Tyr Val Arg Ala Phe Val Lys Ser Lys Met Leu Asn 
            100                 105                 110         


Gln Ala Ala Leu Leu Lys Ser Leu Asn Lys Thr Arg Asn Gly Leu Phe 
        115                 120                 125             


Leu Glu Arg Ile Arg Glu Ile Glu Arg Ile Ile Glu Lys Ser Glu Asp 
    130                 135                 140                 


Ala Val Gly Asp Tyr Val Asp Asp Leu Arg Ser Ala Leu Ile Gly Tyr 
145                 150                 155                 160 


Glu Gly Asn Val Ala Ala Ile Tyr Phe Asp Cys Ile Arg Ala Leu Ile 
                165                 170                 175     


Pro Phe Gly Arg Arg Lys Arg Gly Ala Lys Asp Arg Phe Asn Ser Ala 
            180                 185                 190         


Leu Asn Tyr Ala Tyr Gly Ile Leu Tyr Ser Gln Ile Glu Lys Ala Cys 
        195                 200                 205             


Leu Leu Ala Gly Leu Asp Pro Tyr Leu Gly Phe Val His Ser Asp Arg 
    210                 215                 220                 


Tyr Gly Lys Pro Ser Leu Val Leu Asp Phe Ile Glu Gln Phe Arg Gln 
225                 230                 235                 240 


Pro Ile Ala Asp Arg Ala Val Ile Thr Ile Phe Val Lys Lys Glu Leu 
                245                 250                 255     


Ala Asp Asp Ser Phe Ile Glu Glu Glu Ile Val Gln Leu Ser Ser Lys 
            260                 265                 270         


Gly Lys Lys Lys Ile Val Glu Ala Ile Tyr Gly Arg Leu Ser Ser Glu 
        275                 280                 285             


Phe Thr His Asn Gly Lys Lys Met Thr Phe Glu Lys Val Ile Ile Asp 
    290                 295                 300                 


Lys Ala Arg Glu Phe Ala Gly Cys Ile Leu Glu Met Lys Glu Tyr Glu 
305                 310                 315                 320 


Pro Phe Val His Arg Trp 
                325     


<210>  4
<211>  248
<212>  PRT
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  4

Met Glu Ser Asn Val Asp Ile Val His Leu Gly Arg Arg Gly His Pro 
1               5                   10                  15      


His Ala Arg Val Tyr Pro Cys Thr Leu Gly Gly Thr Thr Leu Thr Arg 
            20                  25                  30          


Arg Arg Gln Leu Glu Ala Tyr Tyr Ala Glu Glu Gly Thr Tyr Leu Ala 
        35                  40                  45              


Lys Gln Phe Ile Met Ala Lys Ile Arg Asn Gln Ala Ala Leu Leu Arg 
    50                  55                  60                  


Ser Leu Gly Lys Ser Arg Gly Asn His Ser Leu Leu Phe Ser Ala Lys 
65                  70                  75                  80  


Ala Ile Gly Lys Gly Thr Asn Asp Val Asp Ala Leu Lys Gly Thr Ile 
                85                  90                  95      


Asp Glu Ile Arg Pro Lys Leu Leu Gly Met Glu Gly Asn Ala Ser Ser 
            100                 105                 110         


Val Tyr Phe Gly Ala Leu Ala Gly Ile Leu Pro Phe Ser Gly Arg Asp 
        115                 120                 125             


Arg Asn Ser Lys Asp Pro Val Asn Ile Leu Leu Asn Tyr Gly Tyr Gly 
    130                 135                 140                 


Met Leu Tyr Gly Glu Ile Glu Arg Ala Cys Val Ile Ala Gly Leu Asp 
145                 150                 155                 160 


Pro Tyr Leu Gly Phe Met His Thr Asp Arg Tyr Gly Lys Pro Ser Met 
                165                 170                 175     


Thr Leu Asp Leu Ile Glu Glu Phe Arg Gln Pro Ile Val Asp Arg Thr 
            180                 185                 190         


Leu Val Thr Leu Phe Ala Gln Lys Gln Ile Glu Asp Ala Asp Phe Glu 
        195                 200                 205             


Ala His Gly Asp Ser Arg Leu Leu Ser Arg Gln Gly Arg Glu Lys Ile 
    210                 215                 220                 


Ile Lys Ala Val Leu Glu Arg Leu Ser Gln Lys Val Arg Arg Ala Gly 
225                 230                 235                 240 


Ala Gln Arg His Pro Val Ser Pro 
                245             


<210>  5
<211>  98
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  5

Met Phe Tyr Trp Val Ile Tyr Asp Ile Ser Glu Asn Lys Lys Arg Gly 
1               5                   10                  15      


Arg Val Ala Arg Ile Cys Lys Asn Tyr Gly Phe Arg Arg Val Gln Lys 
            20                  25                  30          


Ser Ala Phe Ala Gly Glu Thr Ser Lys Asn Lys Val Glu Met Leu Leu 
        35                  40                  45              


Leu Glu Cys Asn Glu Ile Ile Glu Gly Gly Asp Asp Tyr Leu Phe Val 
    50                  55                  60                  


Ile Pro Asn Cys Thr Ser Cys Phe Asn Gly Lys Met Ile Thr Gly Cys 
65                  70                  75                  80  


Leu Asp Glu Lys Arg Val Arg Asn Gln Pro Tyr Met Phe Val Gly Asp 
                85                  90                  95      


Gly Ala 
        


<210>  6
<211>  94
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  6

Met Ile Tyr Trp Val Ile Tyr Asp Ile Thr Asp Asn Lys Val Arg Ser 
1               5                   10                  15      


Lys Val Ala Glu Glu Cys Lys Asn Leu Gly Leu His Arg Val Gln Lys 
            20                  25                  30          


Ser Ser Phe Ile Gly Ile Leu Ser Arg Asn Thr Ala Glu Met Leu Tyr 
        35                  40                  45              


Ile Lys Ile Gly Asp Leu Ile Asp Lys Arg Asp Cys Val Phe Phe Ile 
    50                  55                  60                  


Pro Gln Cys Asn Lys Cys Phe Ala Asp Lys Leu Ile Leu Gly Asp Phe 
65                  70                  75                  80  


Asp Glu Arg Thr Val Glu Ala Lys Asp Phe Ile Val Val Gln 
                85                  90                  


<210>  7
<211>  100
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Aureabacteria bacterium

<400>  7

Met Leu Tyr Trp Leu Ile Tyr Asp Ile Ser Ser Asn Ser Lys Arg Leu 
1               5                   10                  15      


Lys Val Ser Glu Lys Cys Lys Asp Tyr Gly Leu Tyr Arg Val Gln Lys 
            20                  25                  30          


Ser Ala Phe Leu Gly Asp Leu Ser Lys Asn Lys Ala Glu Met Leu Leu 
        35                  40                  45              


Glu Glu Val Gln Asp Ile Met Ala Glu Ser Glu Gly Asp Cys Val Phe 
    50                  55                  60                  


Met Phe Pro Ala Cys Lys Gly Cys Phe Ser Ser Arg Ala Ile Ile Gly 
65                  70                  75                  80  


Glu Phe Asn Glu Ser Leu Ile Glu Glu Lys Glu Phe Val Phe Leu Ala 
                85                  90                  95      


Cys Ser Ser Gln 
            100 


<210>  8
<211>  106
<212>  PRT
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  8

Met Ile Tyr Trp Val Ile Tyr Asp Ile Ser Ala Asn Gly Thr Arg Ser 
1               5                   10                  15      


Arg Val Ala Ser Ala Cys Lys Asn Tyr Gly Phe Lys Arg Ile Gln Lys 
            20                  25                  30          


Ser Ala Phe Leu Gly Asn Ile Thr Lys Asn Lys Ala Asp Met Leu Ala 
        35                  40                  45              


Ile Gln Cys Arg Asp Met Val Lys Glu Glu Gly Asp Cys Val Phe Ile 
    50                  55                  60                  


Ile Pro Ala Cys Glu Gln Cys Phe Arg Gly Lys Glu Ile Ile Gly Glu 
65                  70                  75                  80  


Leu Asp Glu Met Ala Gly Arg Lys Leu Asp Tyr Leu Ile Val Gly Glu 
                85                  90                  95      


Asp Gly Arg Gln Thr Ala Ser Tyr Gly Gly 
            100                 105     


<210>  9
<211>  203
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  9

Met Asn Arg Met Gly Ile Leu Ser Ile Arg Asp Ile Leu Asn Tyr Asn 
1               5                   10                  15      


Tyr Cys Pro Arg Ile Val Tyr Phe Glu Tyr Val Leu Arg Arg Pro Gln 
            20                  25                  30          


Gly Arg Thr Lys Lys Glu Asp Glu Gly Leu Lys Gln His Asn Glu Phe 
        35                  40                  45              


Val Pro Arg Gly Lys Arg Asn Lys Met Val Lys Arg Ile Cys Tyr Asp 
    50                  55                  60                  


Lys Lys Leu Phe Asn Leu Pro Leu Tyr Ser Pro Arg Met Asn Leu Gln 
65                  70                  75                  80  


Thr Val Ala Asp Cys Val Leu Ile Asp Thr Lys Glu Lys Leu Ala Val 
                85                  90                  95      


Pro Met Gln Phe Lys His Gly Lys Thr Pro Ser Cys Leu Tyr Arg Thr 
            100                 105                 110         


Met Lys Tyr Gln Leu Val Ala Glu Ala Leu Leu Ile Glu Glu Cys Leu 
        115                 120                 125             


Gly Leu Ser Cys Pro Tyr Gly Leu Val Lys Phe Leu Pro Glu Glu Thr 
    130                 135                 140                 


Thr Leu Arg Thr Glu Ile Asp Glu Ile Gln Lys Gln Lys Leu Lys Glu 
145                 150                 155                 160 


Gln Leu Glu Ser Ile Asn Asn Val Val Arg Phe Glu Arg Tyr Pro Asp 
                165                 170                 175     


Gly Pro Arg Thr Arg Asn Tyr Cys Gly Asp Cys Trp Tyr His Gly Lys 
            180                 185                 190         


Val Cys Thr Gly Phe Asp Gly Lys Ile Val Gly 
        195                 200             


<210>  10
<211>  197
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  10

Met Thr Thr Met Asp Gly Tyr Leu Thr Ala Lys Asp Leu Met Asn Phe 
1               5                   10                  15      


His Tyr Cys Lys Arg Leu Ile Tyr Phe Glu Asn Val Leu Lys Ile Lys 
            20                  25                  30          


Gln Ala Thr Thr Thr Lys Glu Leu Lys Gly Arg Ala Leu His Asn Ser 
        35                  40                  45              


Phe Ser Val Ser Ser Lys Arg Thr Lys Ile Ile Lys Glu Phe Pro Tyr 
    50                  55                  60                  


Trp Pro Lys Ile Tyr Asn Leu Arg Leu Lys Ser Asp Phe Leu His Leu 
65                  70                  75                  80  


Ile Thr Thr Leu Asp Cys Leu Ile Ile Asn Gln Thr Asp Asn Glu Ala 
                85                  90                  95      


Phe Pro Leu Glu Tyr Lys Tyr Ser Lys Lys Pro Arg Lys Ile Tyr Lys 
            100                 105                 110         


Thr Met Lys Leu Gln Leu Ser Leu Gln Ala Leu Leu Val Asn Glu Leu 
        115                 120                 125             


Leu His Tyr Ser Val Lys Phe Gly Phe Ile Lys Phe Ser Lys Asp Asn 
    130                 135                 140                 


Ser Leu Ala Lys Val Ser Ile Thr Asp Arg Asp Leu Glu Glu Val Arg 
145                 150                 155                 160 


Thr Thr Ile Ser Glu Val Asn Thr Ile Val Glu Lys Glu Ile Leu Pro 
                165                 170                 175     


Pro Pro Thr Glu Tyr Lys Lys Arg Cys Ile Asp Cys Cys Tyr Phe Asn 
            180                 185                 190         


Ile Cys Lys Gly Ile 
        195         


<210>  11
<211>  189
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Aureabacteria bacterium

<400>  11

Met Leu Lys Ser Val Thr Ala Thr Asp Val Met Asn Phe Ser Tyr Cys 
1               5                   10                  15      


Lys Arg Ile Pro Tyr Tyr Val His Val Leu Lys Ile Pro Gln Phe Thr 
            20                  25                  30          


Thr Val Lys Glu Tyr Lys Gly Arg Glu Lys Tyr Asp Asp Phe Lys Tyr 
        35                  40                  45              


Arg Ser Lys Arg Ser Lys Ile Ile Gln Glu Phe Pro His Leu Glu Arg 
    50                  55                  60                  


Lys Tyr Asp Leu Tyr Leu Glu Cys Asp Gly Phe Ser Thr Lys Leu Asp 
65                  70                  75                  80  


Cys Val Phe Phe Asn Asp Asp Asp Ala Phe Pro Leu Gln Leu Lys Tyr 
                85                  90                  95      


Ala Val Lys Pro Lys Lys Met Tyr Ala Thr Thr Arg Arg Gln Leu Leu 
            100                 105                 110         


Leu Glu Ala Phe Leu Ile Glu Gln Cys Leu Gly Lys Lys Val Gln Arg 
        115                 120                 125             


Gly Phe Val Lys Tyr Glu Leu Ser Gly Asp Leu Val Glu Val Asp Leu 
    130                 135                 140                 


Thr Asp Lys Ser Glu Leu Phe Glu Met Phe Lys Glu Tyr Phe Gly Ile 
145                 150                 155                 160 


Ile Met Gly Glu Lys Leu Pro Glu Pro Thr Glu Tyr Leu Lys Arg Cys 
                165                 170                 175     


Arg Asp Cys Cys Tyr Arg Arg Phe Cys Trp Gly Asp Lys 
            180                 185                 


<210>  12
<211>  138
<212>  PRT
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  12

Met Thr Ser Ser Gly Asn Pro Gly Gly Thr Arg Leu Tyr Asp Val Thr 
1               5                   10                  15      


Leu Glu Ser Lys Lys His Gly Leu Ile Thr Lys Ala Asp Cys Ile Leu 
            20                  25                  30          


Phe Asp Arg Glu Lys Gly Glu Ala Tyr Pro Val Gln His Lys Tyr Ser 
        35                  40                  45              


Phe Arg Pro Lys Ile Leu Tyr His Thr Tyr Ile Ser Gln Leu Met Met 
    50                  55                  60                  


Glu Ala Ile Ile Ile Glu Glu Gln Phe Asn Leu Ser Val Pro His Gly 
65                  70                  75                  80  


Phe Ile Val Phe Glu Arg Ser Lys Glu Thr Val Thr Val Asp Leu Gly 
                85                  90                  95      


Asp Lys Gln Lys Val Leu Tyr Val Val Gly Gln Ile Arg Gly Ile Ile 
            100                 105                 110         


Gly Gly Glu Lys Phe Pro Pro Pro Thr Glu Trp Lys Lys Arg Cys Val 
        115                 120                 125             


Asp Cys Cys Tyr Asn Lys Leu Cys Trp Gly 
    130                 135             


<210>  13
<211>  1635
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  13
atgaacatga gtaaaactac gatttcagta aaattaaaga ttattgactt aagctctgag       60

aaaaaagagt ttcttgataa ctattttaac gaatacgcaa aagccacgac gttctgccag      120

ttaagaatac ggcgactttt gagaaataca cactggcttg ggaaaaagga gaagagttca      180

aaaaagtgga tttttgaaag tggaatatgc gatttgtgcg gtgaaaacaa agaacttgtg      240

aatgaagata gaaattcagg cgaacctgca aaaatttgca aaagatgtta taatggaaga      300

tatggcaatc agatgatacg taaacttttc gtttcaacga agaaaagaga agttcaggaa      360

aacatggaca tacgaagagt cgctaaacta aataatacgc attatcaccg cataccggaa      420

gaagcatttg acatgattaa agccgccgat acagcagaaa aaagaagaaa gaagaatgtc      480

gagtatgata aaaaaagaca gatggaattt attgagatgt ttaatgacga aaaaaaacgt      540

gcggcaagac caaaaaaacc aaacgaaagg gaaacccgtt acgttcatat ttctaaattg      600

gaaagtccgt caaagggata tactctgaac ggaataaaaa gaaaaataga cggcatgggt      660

aaaaaaattg agagagcaga aaaaggtctc tcaagaaaga agatttttgg ttatcagggc      720

aatagaatca aacttgattc gaattgggtc cggtttgacc ttgccgaatc ggagattact      780

atcccctcac tgtttaagga aatgaaacta aggataactg gaccgaccaa cgttcattca      840

aaaagcgggc agatatattt tgcagaatgg tttgagcgga taaacaaaca accgaataat      900

tactgttatc tgataagaaa aacaagttcg aacggcaaat atgaatatta tcttcaatat      960

acttatgaag ccgaagttga ggcgaataag gagtacgctg ggtgtttggg ggttgatata     1020

ggatgttcta aacttgctgc cgcagtttat tatgattcaa aaaacaaaaa agcacaaaaa     1080

ccaattgaga tattcacgaa tccgattaaa aaaatcaaga tgcggcgcga gaaactgatt     1140

aaacttcttt ccagagttaa ggtgcggcac agacgcagaa aactcatgca actcagtaaa     1200

actgaaccca ttatagacta tacgtgccac aaaaccgcaa gaaaaattgt tgaaatggca     1260

aatactgcca aagcttttat ctccatggag aatcttgaaa ctgggataaa gcaaaagcaa     1320

caggcaagag aaacaaaaaa gcagaagttt tatcggaata tgtttctttt cagaaaatta     1380

agcaaactaa tagagtacaa ggctctgctg aaagggataa agatagtata tgtgaaaccc     1440

gattatacaa gccaaacttg ttcttcatgt ggcgcagaca aagaaaaaac cgagcgccca     1500

tcacaagcaa tatttcgctg tcttaatcca acatgccgat attatcaaag agacataaat     1560

gccgacttca acgccgcagt gaatatagct aagaaagctt taaataatac tgaagtagta     1620

actacgttat tatga                                                      1635


<210>  14
<211>  1761
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  14
atgccatccg aaacatacat tacgaaaacc ttgtcattaa aactcattcc atcagatgaa       60

gaaaagcagg cgttagaaaa ctattttata acattccaga gggccgtgaa ttttgctata      120

gatagaatag tagatataag aagctccttt agatatctaa acaaaaatga acaatttcca      180

gccgtgtgtg attgctgtgg taagaaagaa aagataatgt atgtgaatat atccaataaa      240

acctttaagt ttaaaccatc aagaaatcag aaggatagat acacgaagga catttataca      300

atcaagccca atgcccacat atgtaagaca tgctacagtg gcgttgcagg aaatatgttt      360

atacgcaaac aaatgtatcc gaacgataaa gaagggtgga aagtttcgcg ttcatacaat      420

atcaaagtta atgcccctgg actgactgga accgaatatg ctatggccat acggaaggca      480

ataagtatat taagatcttt tgaaaagcga cgaagaaatg ctgaaagaag aatcatagag      540

tatgaaaagt ccaaaaaaga gtatttagaa ttgattgatg atgttgaaaa aggaaagaca      600

aataaaatag tggttcttga gaaagaaggc catcagcgag tgaaaagata taaacacaag      660

aattggcctg agaaatggca aggtatttct ttaaataaag caaaaagtaa ggttaaagat      720

attgagaaaa gaataaaaaa gctcaaggag tggaaacacc ctacactaaa tcgaccatat      780

gtcgagttac acaaaaataa tgttaggata gtgggttatg aaacagtgga acttaaatta      840

ggaaacaaaa tgtacaccat acattttgct agcatatcta atttacgaaa accatttaga      900

aaacaaaaga aaaagtccat agaatatctg aaacatctcc taaccctagc gttaaaaaga      960

aatcttgaaa cataccccag cataataaaa agaggtaaga atttcttttt gcagtatcct     1020

gtgcgagtga cagttaaagt gcctaagctg acaaaaaatt ttaaagcttt tggcatcgat     1080

agaggcgtaa ataggcttgc agtaggttgt ataatctcaa aagatggaaa acttaccaat     1140

aaaaatattt ttttcttcca tggaaaggaa gcgtgggcca aggaaaacag atacaagaag     1200

attagggaca gattatacgc tatggccaag aagttgagag gagataaaac caagaaaata     1260

aggctttatc atgagattag gaagaaattt agacataaag tcaaatattt caggagaaac     1320

tatctgcata atatctctaa gcaaattgtt gagattgcaa aggaaaatac accgactgtc     1380

atcgtattag aagatttacg gtacttgaga gaaaggacat atagaggaaa aggaagaagc     1440

aaaaaggcga aaaaaacaaa ttataaatta aatactttta cttacagaat gcttatagat     1500

atgataaaat acaaggcaga agaagcggga gttcctgtaa tgattattga cccaagaaac     1560

acatcacgaa aatgttctaa gtgtggttat gttgacgaaa ataatagaaa acaagcctcg     1620

tttaagtgcc ttaagtgtgg ttatagtctt aatgcagact taaatgcagc tgtcaatata     1680

gcaaaagctt tttatgaatg ccccacgttt agatgggaag aaaaattgca tgcatatgtt     1740

tgttcagagc ccgataaata g                                               1761


<210>  15
<211>  1812
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Aureabacteria bacterium

<400>  15
atgaagtcat ttaagctaaa gttgttgcca acagatgagc aaaacgttct tttaaatgaa       60

gtgttttgta aatgggcatc attatgtacc agaatggcgt ctaaaggaca cgataaagaa      120

cgactggcgc ctcctgattc aagcgggaat tattttaaca aaacacaact caatcaggtg      180

aatactgatg taactgacca tatgggtgcg cttgaagagt cagcaagtca aaaagaaaga      240

gcagttgaga aagtcaaaag aaggttgaag ctgatttcag atatgctctc tgagccaaat      300

ttaagggatg tttctcaaca aaaaccaacc acgttccgtc cattagagtg ggttaaggag      360

ggtctgttaa aaacaaaata ccatactgtg cattattggc aaaaggaatg tgataagtta      420

acaaaacaaa aagaacgaat ggagaaaaca attgagaaga taaagaaagg gaagataacg      480

ttcaaaccaa caaagatgtc cctgcaccaa aattgttttt cgttatcatt cggaaaggga      540

acgttttcaa tgcggccttt tagcgacact aaacgaggca taaatcttga tatgctaact      600

gctcccattc aacctgcaat aggaaaaaac gatggcaaat catctttgag gagcaaagag      660

tttatcgcaa ggaatattga aaactacatt attttttcca tccactcaca actatttggg      720

ctgagcaggt cagaagaact gttgttaaac gcaaaaaaag aggaactcgt tgctaagcga      780

gatgcaatgc tcaaaaagaa atctgattcg ctaagtaaaa aaataaagga attagaaaaa      840

atagtaggaa gaaaaattac tgattcagaa cgttcagaga taatgtctca gggcggcaaa      900

ttgtcttctg aaaagttcag tgaagataat tcatatttga aaacgttaaa ggtgctggca      960

aaagacatta ttgggcgaga ggaattgttc agacttaaga agtacccgat tgtgattaga     1020

aaacctctca acgaacgaaa aaagctcaaa aatcttaaac ctgacgaatg ggaatattat     1080

ttacagttga gttatgatga gttggaaaag aaagagttta caccaaagac aattatggga     1140

atcgatagag gactaaaaca cattcttgct attgcgattt acgaccctgt gcaaaataaa     1200

tttgtaaaaa atatgctcat tccaaatccg atattaggtt ggaagtggaa gttgcgaaag     1260

ataaaaagaa gtattcaaca tatggaaagg agaatacggg ctcagcaaaa tgctcacgtt     1320

cctgagaatc agttgaaaaa acggttgaaa agtattgaga acaaaattga ttattactat     1380

cacaatgtgt cgcggcaaat attgaatctc gctcacgatt tcaaatcagc aatagtggta     1440

gaagacttac agaatatgaa acaacacgga agaaagaaat caaaaggact aagaggacta     1500

aactacgcat taagtaactt tgactatgga aaaattatgg gtcttgttaa gtataaagca     1560

gaatcagaga atgtgcctct tcttaccgtg ttgcctgcag gaacgagtca aaattgcgcg     1620

tattgtctct tgtacggaaa agaacaagga aattatgtgc ggaataatgt caacagtaaa     1680

ataggcaagt gtaagcttca tggagaaata gatgcggaca tcaatgcggc aaggacgatt     1740

gcgatttgtt atcataagaa tattaatgaa ccaaaaccat atggtgaacg aaagactttt     1800

aaaagaaagt aa                                                         1812


<210>  16
<211>  1590
<212>  DNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  16
atggctaaga atactattac aaaaactctg aaactgagaa tagttcgacc atataattct       60

gctgaagtag agaagatagt agctgatgag aaaaacaata gggagaaaat cgccttagaa      120

aaaaataagg ataaggttaa agaggcctgt agcaagcatc tcaaagttgc cgcctattgc      180

acgacgcaag tagaaagaaa tgcatgcctt ttctgcaaag caagaaaatt agacgataag      240

ttctaccaaa agctgagggg acaatttcct gatgctgtat tttggcaaga gatttctgag      300

atattcaggc aattgcagaa gcaagctgct gaaatatata atcaaagtct catcgaacta      360

tattacgaga tttttataaa gggaaaagga attgcaaatg cttcatcagt tgagcattat      420

ctcagtgatg tttgttatac aagagctgcc gaattattca aaaatgctgc gatagcaagc      480

ggtttaagat caaagataaa gagcaatttc aggctcaagg aattaaaaaa tatgaaatca      540

gggcttccga ctacaaaatc agacaacttc cccattcctc ttgtcaagca gaaaggaggg      600

caatataccg gctttgagat ttcaaatcat aattctgatt tcatcataaa aattccgttt      660

ggcagatggc aagtgaaaaa agagattgat aaatacaggc cttgggaaaa gtttgatttt      720

gaacaagtgc agaagtctcc taaacccatc tctctcttgc tgtccacgca gagaagaaaa      780

agaaacaaag ggtggtccaa agatgagggt actgaggcag aaataaagaa agtgatgaat      840

ggagattacc aaacaagcta tattgaggta aaaagaggat cgaaaattgg ggagaagagt      900

gcttggatgc ttaatctttc tatcgatgtc cccaagatcg acaagggagt tgatccgtcc      960

attataggcg gaatcgatgt cggcgtgaaa agcccgcttg tgtgcgctat caacaatgct     1020

ttcagtcgtt actctatctc ggacaatgac ctctttcatt tcaacaaaaa aatgttcgcc     1080

agaaggagga tattgcttaa gaagaatagg cataaaagag caggacatgg tgctaaaaat     1140

aaacttaagc ctatcaccat attaactgaa aaaagcgaga gatttaggaa gaaactaatc     1200

gagaggtggg cgtgcgagat tgcagatttt ttcatcaaaa ataaggttgg aactgtccaa     1260

atggaaaatt tggagtccat gaagagaaaa gaagacagct acttcaacat cagattgaga     1320

ggtttttggc cttatgcaga aatgcaaaat aaaatagaat ttaagctcaa acagtatggt     1380

atagaaataa gaaaagtagc gcctaacaat acctctaaaa cgtgctccaa atgtggtcac     1440

cttaataact attttaattt tgaatacaga aaaaagaaca aatttcctca tttcaagtgt     1500

gaaaagtgca atttcaagga aaatgcggat tataacgccg ctttaaatat ttccaatcca     1560

aaactaaaat caacaaagga agaaccatag                                      1590


<210>  17
<211>  544
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  17

Met Asn Met Ser Lys Thr Thr Ile Ser Val Lys Leu Lys Ile Ile Asp 
1               5                   10                  15      


Leu Ser Ser Glu Lys Lys Glu Phe Leu Asp Asn Tyr Phe Asn Glu Tyr 
            20                  25                  30          


Ala Lys Ala Thr Thr Phe Cys Gln Leu Arg Ile Arg Arg Leu Leu Arg 
        35                  40                  45              


Asn Thr His Trp Leu Gly Lys Lys Glu Lys Ser Ser Lys Lys Trp Ile 
    50                  55                  60                  


Phe Glu Ser Gly Ile Cys Asp Leu Cys Gly Glu Asn Lys Glu Leu Val 
65                  70                  75                  80  


Asn Glu Asp Arg Asn Ser Gly Glu Pro Ala Lys Ile Cys Lys Arg Cys 
                85                  90                  95      


Tyr Asn Gly Arg Tyr Gly Asn Gln Met Ile Arg Lys Leu Phe Val Ser 
            100                 105                 110         


Thr Lys Lys Arg Glu Val Gln Glu Asn Met Asp Ile Arg Arg Val Ala 
        115                 120                 125             


Lys Leu Asn Asn Thr His Tyr His Arg Ile Pro Glu Glu Ala Phe Asp 
    130                 135                 140                 


Met Ile Lys Ala Ala Asp Thr Ala Glu Lys Arg Arg Lys Lys Asn Val 
145                 150                 155                 160 


Glu Tyr Asp Lys Lys Arg Gln Met Glu Phe Ile Glu Met Phe Asn Asp 
                165                 170                 175     


Glu Lys Lys Arg Ala Ala Arg Pro Lys Lys Pro Asn Glu Arg Glu Thr 
            180                 185                 190         


Arg Tyr Val His Ile Ser Lys Leu Glu Ser Pro Ser Lys Gly Tyr Thr 
        195                 200                 205             


Leu Asn Gly Ile Lys Arg Lys Ile Asp Gly Met Gly Lys Lys Ile Glu 
    210                 215                 220                 


Arg Ala Glu Lys Gly Leu Ser Arg Lys Lys Ile Phe Gly Tyr Gln Gly 
225                 230                 235                 240 


Asn Arg Ile Lys Leu Asp Ser Asn Trp Val Arg Phe Asp Leu Ala Glu 
                245                 250                 255     


Ser Glu Ile Thr Ile Pro Ser Leu Phe Lys Glu Met Lys Leu Arg Ile 
            260                 265                 270         


Thr Gly Pro Thr Asn Val His Ser Lys Ser Gly Gln Ile Tyr Phe Ala 
        275                 280                 285             


Glu Trp Phe Glu Arg Ile Asn Lys Gln Pro Asn Asn Tyr Cys Tyr Leu 
    290                 295                 300                 


Ile Arg Lys Thr Ser Ser Asn Gly Lys Tyr Glu Tyr Tyr Leu Gln Tyr 
305                 310                 315                 320 


Thr Tyr Glu Ala Glu Val Glu Ala Asn Lys Glu Tyr Ala Gly Cys Leu 
                325                 330                 335     


Gly Val Asp Ile Gly Cys Ser Lys Leu Ala Ala Ala Val Tyr Tyr Asp 
            340                 345                 350         


Ser Lys Asn Lys Lys Ala Gln Lys Pro Ile Glu Ile Phe Thr Asn Pro 
        355                 360                 365             


Ile Lys Lys Ile Lys Met Arg Arg Glu Lys Leu Ile Lys Leu Leu Ser 
    370                 375                 380                 


Arg Val Lys Val Arg His Arg Arg Arg Lys Leu Met Gln Leu Ser Lys 
385                 390                 395                 400 


Thr Glu Pro Ile Ile Asp Tyr Thr Cys His Lys Thr Ala Arg Lys Ile 
                405                 410                 415     


Val Glu Met Ala Asn Thr Ala Lys Ala Phe Ile Ser Met Glu Asn Leu 
            420                 425                 430         


Glu Thr Gly Ile Lys Gln Lys Gln Gln Ala Arg Glu Thr Lys Lys Gln 
        435                 440                 445             


Lys Phe Tyr Arg Asn Met Phe Leu Phe Arg Lys Leu Ser Lys Leu Ile 
    450                 455                 460                 


Glu Tyr Lys Ala Leu Leu Lys Gly Ile Lys Ile Val Tyr Val Lys Pro 
465                 470                 475                 480 


Asp Tyr Thr Ser Gln Thr Cys Ser Ser Cys Gly Ala Asp Lys Glu Lys 
                485                 490                 495     


Thr Glu Arg Pro Ser Gln Ala Ile Phe Arg Cys Leu Asn Pro Thr Cys 
            500                 505                 510         


Arg Tyr Tyr Gln Arg Asp Ile Asn Ala Asp Phe Asn Ala Ala Val Asn 
        515                 520                 525             


Ile Ala Lys Lys Ala Leu Asn Asn Thr Glu Val Val Thr Thr Leu Leu 
    530                 535                 540                 


<210>  18
<211>  586
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  18

Met Pro Ser Glu Thr Tyr Ile Thr Lys Thr Leu Ser Leu Lys Leu Ile 
1               5                   10                  15      


Pro Ser Asp Glu Glu Lys Gln Ala Leu Glu Asn Tyr Phe Ile Thr Phe 
            20                  25                  30          


Gln Arg Ala Val Asn Phe Ala Ile Asp Arg Ile Val Asp Ile Arg Ser 
        35                  40                  45              


Ser Phe Arg Tyr Leu Asn Lys Asn Glu Gln Phe Pro Ala Val Cys Asp 
    50                  55                  60                  


Cys Cys Gly Lys Lys Glu Lys Ile Met Tyr Val Asn Ile Ser Asn Lys 
65                  70                  75                  80  


Thr Phe Lys Phe Lys Pro Ser Arg Asn Gln Lys Asp Arg Tyr Thr Lys 
                85                  90                  95      


Asp Ile Tyr Thr Ile Lys Pro Asn Ala His Ile Cys Lys Thr Cys Tyr 
            100                 105                 110         


Ser Gly Val Ala Gly Asn Met Phe Ile Arg Lys Gln Met Tyr Pro Asn 
        115                 120                 125             


Asp Lys Glu Gly Trp Lys Val Ser Arg Ser Tyr Asn Ile Lys Val Asn 
    130                 135                 140                 


Ala Pro Gly Leu Thr Gly Thr Glu Tyr Ala Met Ala Ile Arg Lys Ala 
145                 150                 155                 160 


Ile Ser Ile Leu Arg Ser Phe Glu Lys Arg Arg Arg Asn Ala Glu Arg 
                165                 170                 175     


Arg Ile Ile Glu Tyr Glu Lys Ser Lys Lys Glu Tyr Leu Glu Leu Ile 
            180                 185                 190         


Asp Asp Val Glu Lys Gly Lys Thr Asn Lys Ile Val Val Leu Glu Lys 
        195                 200                 205             


Glu Gly His Gln Arg Val Lys Arg Tyr Lys His Lys Asn Trp Pro Glu 
    210                 215                 220                 


Lys Trp Gln Gly Ile Ser Leu Asn Lys Ala Lys Ser Lys Val Lys Asp 
225                 230                 235                 240 


Ile Glu Lys Arg Ile Lys Lys Leu Lys Glu Trp Lys His Pro Thr Leu 
                245                 250                 255     


Asn Arg Pro Tyr Val Glu Leu His Lys Asn Asn Val Arg Ile Val Gly 
            260                 265                 270         


Tyr Glu Thr Val Glu Leu Lys Leu Gly Asn Lys Met Tyr Thr Ile His 
        275                 280                 285             


Phe Ala Ser Ile Ser Asn Leu Arg Lys Pro Phe Arg Lys Gln Lys Lys 
    290                 295                 300                 


Lys Ser Ile Glu Tyr Leu Lys His Leu Leu Thr Leu Ala Leu Lys Arg 
305                 310                 315                 320 


Asn Leu Glu Thr Tyr Pro Ser Ile Ile Lys Arg Gly Lys Asn Phe Phe 
                325                 330                 335     


Leu Gln Tyr Pro Val Arg Val Thr Val Lys Val Pro Lys Leu Thr Lys 
            340                 345                 350         


Asn Phe Lys Ala Phe Gly Ile Asp Arg Gly Val Asn Arg Leu Ala Val 
        355                 360                 365             


Gly Cys Ile Ile Ser Lys Asp Gly Lys Leu Thr Asn Lys Asn Ile Phe 
    370                 375                 380                 


Phe Phe His Gly Lys Glu Ala Trp Ala Lys Glu Asn Arg Tyr Lys Lys 
385                 390                 395                 400 


Ile Arg Asp Arg Leu Tyr Ala Met Ala Lys Lys Leu Arg Gly Asp Lys 
                405                 410                 415     


Thr Lys Lys Ile Arg Leu Tyr His Glu Ile Arg Lys Lys Phe Arg His 
            420                 425                 430         


Lys Val Lys Tyr Phe Arg Arg Asn Tyr Leu His Asn Ile Ser Lys Gln 
        435                 440                 445             


Ile Val Glu Ile Ala Lys Glu Asn Thr Pro Thr Val Ile Val Leu Glu 
    450                 455                 460                 


Asp Leu Arg Tyr Leu Arg Glu Arg Thr Tyr Arg Gly Lys Gly Arg Ser 
465                 470                 475                 480 


Lys Lys Ala Lys Lys Thr Asn Tyr Lys Leu Asn Thr Phe Thr Tyr Arg 
                485                 490                 495     


Met Leu Ile Asp Met Ile Lys Tyr Lys Ala Glu Glu Ala Gly Val Pro 
            500                 505                 510         


Val Met Ile Ile Asp Pro Arg Asn Thr Ser Arg Lys Cys Ser Lys Cys 
        515                 520                 525             


Gly Tyr Val Asp Glu Asn Asn Arg Lys Gln Ala Ser Phe Lys Cys Leu 
    530                 535                 540                 


Lys Cys Gly Tyr Ser Leu Asn Ala Asp Leu Asn Ala Ala Val Asn Ile 
545                 550                 555                 560 


Ala Lys Ala Phe Tyr Glu Cys Pro Thr Phe Arg Trp Glu Glu Lys Leu 
                565                 570                 575     


His Ala Tyr Val Cys Ser Glu Pro Asp Lys 
            580                 585     


<210>  19
<211>  603
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Aureabacteria bacterium

<400>  19

Met Lys Ser Phe Lys Leu Lys Leu Leu Pro Thr Asp Glu Gln Asn Val 
1               5                   10                  15      


Leu Leu Asn Glu Val Phe Cys Lys Trp Ala Ser Leu Cys Thr Arg Met 
            20                  25                  30          


Ala Ser Lys Gly His Asp Lys Glu Arg Leu Ala Pro Pro Asp Ser Ser 
        35                  40                  45              


Gly Asn Tyr Phe Asn Lys Thr Gln Leu Asn Gln Val Asn Thr Asp Val 
    50                  55                  60                  


Thr Asp His Met Gly Ala Leu Glu Glu Ser Ala Ser Gln Lys Glu Arg 
65                  70                  75                  80  


Ala Val Glu Lys Val Lys Arg Arg Leu Lys Leu Ile Ser Asp Met Leu 
                85                  90                  95      


Ser Glu Pro Asn Leu Arg Asp Val Ser Gln Gln Lys Pro Thr Thr Phe 
            100                 105                 110         


Arg Pro Leu Glu Trp Val Lys Glu Gly Leu Leu Lys Thr Lys Tyr His 
        115                 120                 125             


Thr Val His Tyr Trp Gln Lys Glu Cys Asp Lys Leu Thr Lys Gln Lys 
    130                 135                 140                 


Glu Arg Met Glu Lys Thr Ile Glu Lys Ile Lys Lys Gly Lys Ile Thr 
145                 150                 155                 160 


Phe Lys Pro Thr Lys Met Ser Leu His Gln Asn Cys Phe Ser Leu Ser 
                165                 170                 175     


Phe Gly Lys Gly Thr Phe Ser Met Arg Pro Phe Ser Asp Thr Lys Arg 
            180                 185                 190         


Gly Ile Asn Leu Asp Met Leu Thr Ala Pro Ile Gln Pro Ala Ile Gly 
        195                 200                 205             


Lys Asn Asp Gly Lys Ser Ser Leu Arg Ser Lys Glu Phe Ile Ala Arg 
    210                 215                 220                 


Asn Ile Glu Asn Tyr Ile Ile Phe Ser Ile His Ser Gln Leu Phe Gly 
225                 230                 235                 240 


Leu Ser Arg Ser Glu Glu Leu Leu Leu Asn Ala Lys Lys Glu Glu Leu 
                245                 250                 255     


Val Ala Lys Arg Asp Ala Met Leu Lys Lys Lys Ser Asp Ser Leu Ser 
            260                 265                 270         


Lys Lys Ile Lys Glu Leu Glu Lys Ile Val Gly Arg Lys Ile Thr Asp 
        275                 280                 285             


Ser Glu Arg Ser Glu Ile Met Ser Gln Gly Gly Lys Leu Ser Ser Glu 
    290                 295                 300                 


Lys Phe Ser Glu Asp Asn Ser Tyr Leu Lys Thr Leu Lys Val Leu Ala 
305                 310                 315                 320 


Lys Asp Ile Ile Gly Arg Glu Glu Leu Phe Arg Leu Lys Lys Tyr Pro 
                325                 330                 335     


Ile Val Ile Arg Lys Pro Leu Asn Glu Arg Lys Lys Leu Lys Asn Leu 
            340                 345                 350         


Lys Pro Asp Glu Trp Glu Tyr Tyr Leu Gln Leu Ser Tyr Asp Glu Leu 
        355                 360                 365             


Glu Lys Lys Glu Phe Thr Pro Lys Thr Ile Met Gly Ile Asp Arg Gly 
    370                 375                 380                 


Leu Lys His Ile Leu Ala Ile Ala Ile Tyr Asp Pro Val Gln Asn Lys 
385                 390                 395                 400 


Phe Val Lys Asn Met Leu Ile Pro Asn Pro Ile Leu Gly Trp Lys Trp 
                405                 410                 415     


Lys Leu Arg Lys Ile Lys Arg Ser Ile Gln His Met Glu Arg Arg Ile 
            420                 425                 430         


Arg Ala Gln Gln Asn Ala His Val Pro Glu Asn Gln Leu Lys Lys Arg 
        435                 440                 445             


Leu Lys Ser Ile Glu Asn Lys Ile Asp Tyr Tyr Tyr His Asn Val Ser 
    450                 455                 460                 


Arg Gln Ile Leu Asn Leu Ala His Asp Phe Lys Ser Ala Ile Val Val 
465                 470                 475                 480 


Glu Asp Leu Gln Asn Met Lys Gln His Gly Arg Lys Lys Ser Lys Gly 
                485                 490                 495     


Leu Arg Gly Leu Asn Tyr Ala Leu Ser Asn Phe Asp Tyr Gly Lys Ile 
            500                 505                 510         


Met Gly Leu Val Lys Tyr Lys Ala Glu Ser Glu Asn Val Pro Leu Leu 
        515                 520                 525             


Thr Val Leu Pro Ala Gly Thr Ser Gln Asn Cys Ala Tyr Cys Leu Leu 
    530                 535                 540                 


Tyr Gly Lys Glu Gln Gly Asn Tyr Val Arg Asn Asn Val Asn Ser Lys 
545                 550                 555                 560 


Ile Gly Lys Cys Lys Leu His Gly Glu Ile Asp Ala Asp Ile Asn Ala 
                565                 570                 575     


Ala Arg Thr Ile Ala Ile Cys Tyr His Lys Asn Ile Asn Glu Pro Lys 
            580                 585                 590         


Pro Tyr Gly Glu Arg Lys Thr Phe Lys Arg Lys 
        595                 600             


<210>  20
<211>  529
<212>  PRT
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  20

Met Ala Lys Asn Thr Ile Thr Lys Thr Leu Lys Leu Arg Ile Val Arg 
1               5                   10                  15      


Pro Tyr Asn Ser Ala Glu Val Glu Lys Ile Val Ala Asp Glu Lys Asn 
            20                  25                  30          


Asn Arg Glu Lys Ile Ala Leu Glu Lys Asn Lys Asp Lys Val Lys Glu 
        35                  40                  45              


Ala Cys Ser Lys His Leu Lys Val Ala Ala Tyr Cys Thr Thr Gln Val 
    50                  55                  60                  


Glu Arg Asn Ala Cys Leu Phe Cys Lys Ala Arg Lys Leu Asp Asp Lys 
65                  70                  75                  80  


Phe Tyr Gln Lys Leu Arg Gly Gln Phe Pro Asp Ala Val Phe Trp Gln 
                85                  90                  95      


Glu Ile Ser Glu Ile Phe Arg Gln Leu Gln Lys Gln Ala Ala Glu Ile 
            100                 105                 110         


Tyr Asn Gln Ser Leu Ile Glu Leu Tyr Tyr Glu Ile Phe Ile Lys Gly 
        115                 120                 125             


Lys Gly Ile Ala Asn Ala Ser Ser Val Glu His Tyr Leu Ser Asp Val 
    130                 135                 140                 


Cys Tyr Thr Arg Ala Ala Glu Leu Phe Lys Asn Ala Ala Ile Ala Ser 
145                 150                 155                 160 


Gly Leu Arg Ser Lys Ile Lys Ser Asn Phe Arg Leu Lys Glu Leu Lys 
                165                 170                 175     


Asn Met Lys Ser Gly Leu Pro Thr Thr Lys Ser Asp Asn Phe Pro Ile 
            180                 185                 190         


Pro Leu Val Lys Gln Lys Gly Gly Gln Tyr Thr Gly Phe Glu Ile Ser 
        195                 200                 205             


Asn His Asn Ser Asp Phe Ile Ile Lys Ile Pro Phe Gly Arg Trp Gln 
    210                 215                 220                 


Val Lys Lys Glu Ile Asp Lys Tyr Arg Pro Trp Glu Lys Phe Asp Phe 
225                 230                 235                 240 


Glu Gln Val Gln Lys Ser Pro Lys Pro Ile Ser Leu Leu Leu Ser Thr 
                245                 250                 255     


Gln Arg Arg Lys Arg Asn Lys Gly Trp Ser Lys Asp Glu Gly Thr Glu 
            260                 265                 270         


Ala Glu Ile Lys Lys Val Met Asn Gly Asp Tyr Gln Thr Ser Tyr Ile 
        275                 280                 285             


Glu Val Lys Arg Gly Ser Lys Ile Gly Glu Lys Ser Ala Trp Met Leu 
    290                 295                 300                 


Asn Leu Ser Ile Asp Val Pro Lys Ile Asp Lys Gly Val Asp Pro Ser 
305                 310                 315                 320 


Ile Ile Gly Gly Ile Asp Val Gly Val Lys Ser Pro Leu Val Cys Ala 
                325                 330                 335     


Ile Asn Asn Ala Phe Ser Arg Tyr Ser Ile Ser Asp Asn Asp Leu Phe 
            340                 345                 350         


His Phe Asn Lys Lys Met Phe Ala Arg Arg Arg Ile Leu Leu Lys Lys 
        355                 360                 365             


Asn Arg His Lys Arg Ala Gly His Gly Ala Lys Asn Lys Leu Lys Pro 
    370                 375                 380                 


Ile Thr Ile Leu Thr Glu Lys Ser Glu Arg Phe Arg Lys Lys Leu Ile 
385                 390                 395                 400 


Glu Arg Trp Ala Cys Glu Ile Ala Asp Phe Phe Ile Lys Asn Lys Val 
                405                 410                 415     


Gly Thr Val Gln Met Glu Asn Leu Glu Ser Met Lys Arg Lys Glu Asp 
            420                 425                 430         


Ser Tyr Phe Asn Ile Arg Leu Arg Gly Phe Trp Pro Tyr Ala Glu Met 
        435                 440                 445             


Gln Asn Lys Ile Glu Phe Lys Leu Lys Gln Tyr Gly Ile Glu Ile Arg 
    450                 455                 460                 


Lys Val Ala Pro Asn Asn Thr Ser Lys Thr Cys Ser Lys Cys Gly His 
465                 470                 475                 480 


Leu Asn Asn Tyr Phe Asn Phe Glu Tyr Arg Lys Lys Asn Lys Phe Pro 
                485                 490                 495     


His Phe Lys Cys Glu Lys Cys Asn Phe Lys Glu Asn Ala Asp Tyr Asn 
            500                 505                 510         


Ala Ala Leu Asn Ile Ser Asn Pro Lys Leu Lys Ser Thr Lys Glu Glu 
        515                 520                 525             


Pro 
    


<210>  21
<211>  5539
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  21
tcgcgtctat ggcgtgattt tgcagcttcc ctaaattcag ccccttctcc tcaaagccca       60

gaagctcctt taatgcctgc tcgtttgcgc cctccacctt tgagcccggg gcggcgggga      120

agatgctgcg caccaatctt ccttccttgt agactccaag cgccctaacc cttgcgatta      180

catactccca gtccgcagtc gggaaattct gcggcatcgg ggagcctttc tcgtactctg      240

aaacgctttc cgcatgctca aaatagcggt ttgcgcgcat tatctcggaa attgtgccaa      300

aaagcattcc atcctcgcag cgtgtctgga cgaactgccc cttccttaca ttcggggagg      360

agattacgaa ggagaagaag gaggtggtgg ggctgtctat tgtggagatg accgtgccaa      420

gggaggtgga atccatgaag aggttttgag gagaaaatta atatatggaa ttgagggggg      480

tcggacttct accctgtaag tgtttataag gagaactcca tatatacttc ggatatgcaa      540

ctaataattg acgattatgg cgcatatctt gggcagaagg acaacctctt ccaaataagg      600

aagaaagacg ggacgtgtga agaatattct gccgacaagg ttgagcagat acttcttgtg      660

aaaaatagct gtatttcttc aagagccgca ctcttggcag cacgaaacaa catagatgta      720

gtgtttgtag gaaaattcgg aatgccggaa ggaaggattt ttcctgcatg tcttggagga      780

acaaatctca taagaagaaa acaacttgaa gcagggcaga atgagaaagg agggaaaatt      840

gcaataaaac ttatctgggc aaagatcaag aatgaggaat ttttccttaa aactctcaac      900

aaaagcagaa ctgcgcctct tcttttggag aaagcggaaa aaataagcgc tattgcggag      960

caagtccggc agatgttagg cgagaaattt gatgcagata gggtttttgg ttttgaagga     1020

ttggctgcgg cgcactattt tgagggattg tcacaggtaa tgccgattga aaagcgcgac     1080

caagagggaa aagatgcccc aaatgcactc ttgaattatg gttatggaat gttgtacgga     1140

gagatagaga aagcctgcct ttttgccggt ttggacccgt atcttggctt tcttcatgca     1200

gataggtacg gcaagccctc tcttgtactt gatttgatag aagagttcag accggttatt     1260

gttgataggg cgattattac gctttacgca cagaaacaga taaacgagag tgattttgag     1320

cagggaggag ataagatttt tctttcaaaa gaagggagaa agaagatgat aaaggcaatt     1380

atggaaagac tgcatgcaaa aataacttca gatgggcgca agcttgagct ttcggtgata     1440

atacaggagc aggcgcgaag aatcgcctcc tttgtgaagg gagagagcga gtttgagcct     1500

tttctttaca ggtggtagga tgttttattg ggtaatttat gatataagcg aaaacaagaa     1560

acgcggcagg gtggcaagaa tatgcaaaaa ctacgggttt agaagagtgc agaagagcgc     1620

ctttgcaggc gaaacttcaa agaataaggt ggagatgctg ttattggaat gcaatgagat     1680

tatagaggga ggggatgatt atttgtttgt cattccgaac tgcacaagct gtttcaatgg     1740

gaaaatgata accggctgtc ttgacgagaa aagagtgaga aatcagccgt atatgtttgt     1800

aggtgatggc gcatgaacag aatgggaatt ttgagcattc gagacatatt gaattacaac     1860

tactgcccgc gcatagtata ttttgagtat gttctgcgca gaccacaggg caggacgaaa     1920

aaggaggatg agggattgaa acagcataat gaatttgtgc caagagggaa gaggaataag     1980

atggttaaac ggatttgtta tgacaagaag ctgtttaatc tgccgcttta ttctccgcgc     2040

atgaaccttc aaactgtggc ggattgcgtg cttattgaca caaaagagaa gcttgctgtt     2100

ccgatgcagt ttaagcatgg aaaaacacct tcttgcttgt atcggactat gaaataccag     2160

cttgtagcgg aggcgttgct gattgaggag tgccttgggc tttcatgtcc ttatggactt     2220

gtgaaattct tacctgaaga aacaactctt agaacagaaa tagacgaaat tcaaaagcaa     2280

aaacttaaag aacagcttga gagtattaac aacgtggtga ggtttgaaag gtatcccgat     2340

ggtccgagaa cgaggaatta ctgcggggac tgctggtatc atggaaaagt ttgcacggga     2400

tttgacggca aaatagtggg atgaacatga gtaaaactac gatttcagta aaattaaaga     2460

ttattgactt aagctctgag aaaaaagagt ttcttgataa ctattttaac gaatacgcaa     2520

aagccacgac gttctgccag ttaagaatac ggcgactttt gagaaataca cactggcttg     2580

ggaaaaagga gaagagttca aaaaagtgga tttttgaaag tggaatatgc gatttgtgcg     2640

gtgaaaacaa agaacttgtg aatgaagata gaaattcagg cgaacctgca aaaatttgca     2700

aaagatgtta taatggaaga tatggcaatc agatgatacg taaacttttc gtttcaacga     2760

agaaaagaga agttcaggaa aacatggaca tacgaagagt cgctaaacta aataatacgc     2820

attatcaccg cataccggaa gaagcatttg acatgattaa agccgccgat acagcagaaa     2880

aaagaagaaa gaagaatgtc gagtatgata aaaaaagaca gatggaattt attgagatgt     2940

ttaatgacga aaaaaaacgt gcggcaagac caaaaaaacc aaacgaaagg gaaacccgtt     3000

acgttcatat ttctaaattg gaaagtccgt caaagggata tactctgaac ggaataaaaa     3060

gaaaaataga cggcatgggt aaaaaaattg agagagcaga aaaaggtctc tcaagaaaga     3120

agatttttgg ttatcagggc aatagaatca aacttgattc gaattgggtc cggtttgacc     3180

ttgccgaatc ggagattact atcccctcac tgtttaagga aatgaaacta aggataactg     3240

gaccgaccaa cgttcattca aaaagcgggc agatatattt tgcagaatgg tttgagcgga     3300

taaacaaaca accgaataat tactgttatc tgataagaaa aacaagttcg aacggcaaat     3360

atgaatatta tcttcaatat acttatgaag ccgaagttga ggcgaataag gagtacgctg     3420

ggtgtttggg ggttgatata ggatgttcta aacttgctgc cgcagtttat tatgattcaa     3480

aaaacaaaaa agcacaaaaa ccaattgaga tattcacgaa tccgattaaa aaaatcaaga     3540

tgcggcgcga gaaactgatt aaacttcttt ccagagttaa ggtgcggcac agacgcagaa     3600

aactcatgca actcagtaaa actgaaccca ttatagacta tacgtgccac aaaaccgcaa     3660

gaaaaattgt tgaaatggca aatactgcca aagcttttat ctccatggag aatcttgaaa     3720

ctgggataaa gcaaaagcaa caggcaagag aaacaaaaaa gcagaagttt tatcggaata     3780

tgtttctttt cagaaaatta agcaaactaa tagagtacaa ggctctgctg aaagggataa     3840

agatagtata tgtgaaaccc gattatacaa gccaaacttg ttcttcatgt ggcgcagaca     3900

aagaaaaaac cgagcgccca tcacaagcaa tatttcgctg tcttaatcca acatgccgat     3960

attatcaaag agacataaat gccgacttca acgccgcagt gaatatagct aagaaagctt     4020

taaataatac tgaagtagta actacgttat tatgatttac tccgagtaat cggatgtgga     4080

ttatagcaca gcaacctata tggaagctgg gaaccggttt atccggaaat gcgcaccgtt     4140

gcatggaatt atgtgcgctt aagaccttat gatatcgcgc ggcttgactt cgcgatagac     4200

aggtcaacta ttgtctcggt tcaacgtgcc aattagcagg tctttataaa tagcctgcag     4260

attttcaagt tgcttttctt agtgcagaaa agaaggcagg agaagcctcc gtttggcaaa     4320

aaaaggcggt tgtatctact gtttcagcgc acgaattaac gagatgagag atgcaacttc     4380

actgtcagat aaagaataag ccactctggt gtccgtttca gcgcacgaat taacgagatg     4440

agagatgcaa ctctgatatt tccgagcgtt gaggatgtgg caactggggt ttcagcgcac     4500

gaattaacga gatgagagat gcaactagac aagctcacga atgtagtagc tcatgttgcc     4560

tttgtttcag cgcacgaatt aacgagatga gagatgcaac tctctccgcg caaatcgtat     4620

ctccatgttc cgctccgttt cagcgcacga attaacgaga tgagagatgc aaccagccat     4680

ttatcttctt atttactatg attgggcggg tttcagcgca cgaattaacg agatgagaga     4740

tgcaactttc tgtcaatcct tccgccaata ctttgttttc aagtttcagc gcacgaatta     4800

acgagatgag agatgcaact ggatataggg tatttgagat accccacacg ggcttgtttc     4860

agcgcacgaa ttaacgagat gagagatgca actatgattt actgcgctcg tagttgcgac     4920

aaagtggcgt ttcagcgcac gaattaacga gatgagagat gcaacaattc agctaccgag     4980

tcattcccct tcatttttga tgtttcagcg cacgaattaa cgagatgaga gatgcaacac     5040

agtagaagat aaaacagaat tagaataaga tggcttccag cctgatggtc gtgctcataa     5100

ccgaattgct gaagtatacg tgcaagctcc cttccagaaa tgacgggcag tttaggcatg     5160

tacctcaaca atttcttccc gtattgacgg cggaaccggc tccccgtgct ttttcaggct     5220

cgcaagatag cccttgatgg cgtctttaac gtttgcaagc gcatcttccc tagttgttcc     5280

ctgcgaaaca cagcccggaa gcgaggtgca aaccgcgacg tatgcaccgt cttcgtcttc     5340

ttctacaatc accctgaatt tcataagtat ctttgggctt tttggagttt ataagaatga     5400

tggatttggg aagttgcacc gcgcggatta gtgggagccc cgtcatttcg gcgcatccaa     5460

aaggagtata agctccctcg tttttgcttc aaattccttt tttcttcaat tccgcaaatc     5520

tgcctttgcg ggagcttcg                                                  5539


<210>  22
<211>  6111
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  22
agtttcaatc cctccccctg cattgcaacg cagctcgttg catccgcagg cgatcttcga       60

tcgcctttgc ttaagccttt gacacagaaa ggataggaaa ggcttaaatc cctgtgctgt      120

taaaatacca gtgaagaggt caaggcatga ggattgagaa gaaaatatgg ccggagtatt      180

ttcagaaaat aattgatgga gtcaaaacct ttgagttaag gctggcagat tttgagtgca      240

ggcctggtga catactggtt ttgagggaat gggacccaag aacaaaagag tacacgggca      300

gagttattga aaagaaggtc acttacgtgg ccaaaagcaa agacatgagg tcctggcctg      360

acgaggacat aaggaaatat gggtttctgg ttattgggtt taaatgagcg gcggttgata      420

tgttttcaat ggtggccata tgattagata atcgacaaac atgcgaatcc tttttatatg      480

tgaaaacaag aaataaaacg atgccatccg aaacatacat tacgaaaacc ttgtcattaa      540

aactcattcc atcagatgaa gaaaagcagg cgttagaaaa ctattttata acattccaga      600

gggccgtgaa ttttgctata gatagaatag tagatataag aagctccttt agatatctaa      660

acaaaaatga acaatttcca gccgtgtgtg attgctgtgg taagaaagaa aagataatgt      720

atgtgaatat atccaataaa acctttaagt ttaaaccatc aagaaatcag aaggatagat      780

acacgaagga catttataca atcaagccca atgcccacat atgtaagaca tgctacagtg      840

gcgttgcagg aaatatgttt atacgcaaac aaatgtatcc gaacgataaa gaagggtgga      900

aagtttcgcg ttcatacaat atcaaagtta atgcccctgg actgactgga accgaatatg      960

ctatggccat acggaaggca ataagtatat taagatcttt tgaaaagcga cgaagaaatg     1020

ctgaaagaag aatcatagag tatgaaaagt ccaaaaaaga gtatttagaa ttgattgatg     1080

atgttgaaaa aggaaagaca aataaaatag tggttcttga gaaagaaggc catcagcgag     1140

tgaaaagata taaacacaag aattggcctg agaaatggca aggtatttct ttaaataaag     1200

caaaaagtaa ggttaaagat attgagaaaa gaataaaaaa gctcaaggag tggaaacacc     1260

ctacactaaa tcgaccatat gtcgagttac acaaaaataa tgttaggata gtgggttatg     1320

aaacagtgga acttaaatta ggaaacaaaa tgtacaccat acattttgct agcatatcta     1380

atttacgaaa accatttaga aaacaaaaga aaaagtccat agaatatctg aaacatctcc     1440

taaccctagc gttaaaaaga aatcttgaaa cataccccag cataataaaa agaggtaaga     1500

atttcttttt gcagtatcct gtgcgagtga cagttaaagt gcctaagctg acaaaaaatt     1560

ttaaagcttt tggcatcgat agaggcgtaa ataggcttgc agtaggttgt ataatctcaa     1620

aagatggaaa acttaccaat aaaaatattt ttttcttcca tggaaaggaa gcgtgggcca     1680

aggaaaacag atacaagaag attagggaca gattatacgc tatggccaag aagttgagag     1740

gagataaaac caagaaaata aggctttatc atgagattag gaagaaattt agacataaag     1800

tcaaatattt caggagaaac tatctgcata atatctctaa gcaaattgtt gagattgcaa     1860

aggaaaatac accgactgtc atcgtattag aagatttacg gtacttgaga gaaaggacat     1920

atagaggaaa aggaagaagc aaaaaggcga aaaaaacaaa ttataaatta aatactttta     1980

cttacagaat gcttatagat atgataaaat acaaggcaga agaagcggga gttcctgtaa     2040

tgattattga cccaagaaac acatcacgaa aatgttctaa gtgtggttat gttgacgaaa     2100

ataatagaaa acaagcctcg tttaagtgcc ttaagtgtgg ttatagtctt aatgcagact     2160

taaatgcagc tgtcaatata gcaaaagctt tttatgaatg ccccacgttt agatgggaag     2220

aaaaattgca tgcatatgtt tgttcagagc ccgataaata gcaaatttac ttattcggag     2280

cctgtttaag ccattagaaa aagataaata ttaagaagca cataatttat tttggttaca     2340

tatcactgga taatgagaac agctgtagat taagctgttt gatgtattgt attatgctcc     2400

actttaataa gtggtgcctt ccaaagctat atgctgaggg aggatgggcg ctgttgcagc     2460

gtctgcccac ctcagagtgg gtatccttac ctattttgaa aggttctgta agtgtttata     2520

aatccgattg caattttgca acttacctat ttttaagttt cagatatctc gatagacgca     2580

gcaatactca aaaattgtct gccattgcag aacccaaagt aataggtcaa ggaatgcaac     2640

tgactaaaca aagtttcgct aaactagaag aacaggccaa ttgcagaacc caaagtaata     2700

ggtcaaggaa tgcaactcaa tatcagacgc tttattcact ctaggagcta cccttattgc     2760

agaacccaaa gtaataggtc aaggaatgca acattatatt tattgttatg ttatcatatc     2820

tcccaaacaa aagtattgca gaacccaaag taataggtca aggaatgcaa ctaggtgttg     2880

ttaagcgaca cggttagaag gtaatcttga ttattgcaga acccaaagta ataggtcaag     2940

gaatgcaact cggccttttt ccagccaagg gcttttacta ttgccctatt gcagaaccca     3000

aagtaatagg tcaaggaatg caaccaagcg aaaagtattt atataacata ggtttgtttc     3060

attgcagaac ccaaagtaat aggtcaagga atgcaactat tcttccaaat tcaacacctc     3120

caaaatattt ataattgcag aacccaaagt aataggtcaa ggaatgcaac ttgacagcca     3180

agctagaaag ttgttaaaca gctttaattg cagaacccaa agtaataggt caaggaatgc     3240

aactatgtta aaatcgctat cgggcgtgga agggggtagc gaattgcaga acccaaagta     3300

ataggtcaag gaatgcaacc atagtatccc tgcgtttgct ctgcaaccgc aggttgtcta     3360

ttgcagaacc caaagtaata ggtcaaggaa tgcaactctg gatatctggt ccctccacga     3420

aaccatcacc atcattgcag aacccaaagt aataggtcaa ggaatgcaac caccttttgg     3480

tatagcccag aagcatcaaa aacatgtgaa aaattgcaga acccaaagta ataggtcaag     3540

gaatgcaact ctttttagct tttctcggca gtttatacca catatcctta ttgcagaacc     3600

caaagtaata ggtcaaggaa tgcaacggta atgtcagccc atctgacgca acggcatttg     3660

agacaattgc agaacccaaa gtaataggtc aaggaatgca tgagaaccac ataattttta     3720

aattgcaggt acttatcatt ttttatgatt ttagtgataa acgatttttc aacattcctg     3780

gggaagaaag gggaccgttt tgtaattaaa aaggaaaata agcgtgaaga attttctaca     3840

aataacgttg aacaaatcat aattgctgca gtctcatcta tctcctatgg agctattcga     3900

ttggcaatta aacactctat tgatgtggtt tttttaagca gaggaggtac tcctttaggc     3960

aggatatacc cctgtaaact cggtggaaca accttaacga gaaaaaaaca attagaggct     4020

tattattcaa cagttggtac aaacatcgta aaaaatctcg ttaaagcaaa gattatgaac     4080

caagcctatt ttttgaagtc tttagaaaaa acaagaaaag atattaattt cacttctgaa     4140

attaacagca ttgttaatat tgctaaaaag attccaggtc tcacaggtct aatagatgat     4200

atacggggaa ctttattggg atatgaaggc attgcagcca acaaatattt tagttccttg     4260

tctaacatac taccatttaa aggaagggac agaacaagta atgattacgt aaatattgta     4320

ttgaattatg gatatggtgt tctgtacacg gaagcagaga aagcgtgtat tctagcaggt     4380

cttgatccat atttcggttt tttgcacaaa gataggtaca acaaaccttc aatggtattg     4440

gaccttgtgg aaatatttag accaatcata gtggacaggg cagttgttac tttgttttcc     4500

caaaaacaga taaattcgaa gtgttttgag aaagaaacat atggggatgt ttttttaagt     4560

aaagagggta gggaaaaaat cttatctgct cttctatctc gcctcaatca gcagatacgc     4620

tttaaaggta agaaaacaag ctttaaaaac atcatattag gagaaagccg ttctatagct     4680

caatatgttc ttggtaatat accagaatat gagccgtttg tttataggtg gtaattatga     4740

tatattgggt gatttatgac atcacagaca ataaagttag aagcaaggtt gccgaggagt     4800

gcaagaactt ggggttacat cgagtccaaa aaagttcttt tattggcatt ctctctagaa     4860

atacagccga gatgttatat attaaaatag gggatttaat tgataaaaga gattgtgtgt     4920

tctttattcc acaatgtaac aaatgttttg cagacaaact tattcttggc gattttgatg     4980

aaaggactgt agaagcaaaa gatttcatcg tggtgcaatg acaacgatgg atggttattt     5040

aactgctaag gatttaatga actttcatta ttgtaaaaga ttaatatatt ttgagaatgt     5100

attgaaaatt aaacaagcta caaccaccaa agaactaaaa ggtcgcgcat tacacaacag     5160

tttttctgta tcatcaaaga gaaccaagat aataaaggag tttccatatt ggcctaagat     5220

atataatctt agattaaaat cagatttttt gcaccttata actacattag actgcttgat     5280

tataaaccaa acagataatg aggcatttcc gctggaatac aaatattcca aaaaaccacg     5340

caagatttat aaaaccatga aattgcaact gtctcttcaa gcccttctcg taaatgaact     5400

tttacattat agtgtgaagt ttggtttcat aaagttttcc aaagacaatt ctttggccaa     5460

agtaagcata acagatagag atttagaaga agtgagaacg actatatctg aggttaatac     5520

aatagtagag aaggagattt tacctccacc caccgaatat aaaaaaagat gtattgactg     5580

ttgctatttc aatatatgca aaggaatcta aacaccctct cacttcacag tcacactctt     5640

ggccaggttt ctgggcctgt cggggtctag gcctttgagg acggccagtt ggtaggccag     5700

tatctggatt gggatgattt ggaggattgg gccgagctcc tcgctttcag gcgtttttat     5760

ccagtagtca aaaatatcgt aatttttgtg agagactccg atgacatagg cccctcttgt     5820

ttttacctca tttgcgtttg ctatgatgtc tttgtcatcc ttggaaacaa agacaataac     5880

agggcttcct ttttttatca gagccagggg gccatgcttt agctctcctc ctgcaaaggc     5940

ctctgcgtgt atgtatgaca cctccttgat ctttagggca gcctccagtg ctgttggata     6000

ctgcagggac cttcctagca cgtatatgtg ttcctcattt aagaggcgtt tggctaatgc     6060

cctgagcctg tctctcatgt tcctagacgt caggttgtat atatccatgt a              6111


<210>  23
<211>  8356
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Aureabacteria bacterium

<400>  23
tgcgggtgaa tcttttattt cttggatgtg tcattaaatt aatatattag aaaatatatt       60

tttagttatg gattttcaac aagttatttt tgtggttggt attgttttcg gcttattggt      120

ggcaggaggc atagtggggt ggtacgtcac gcgaatgcgc tttatgagga agtgggatgt      180

gttggttccg gaattgcgca aggatgcgat tatgcgttca cgcgcaaact tgggaggaaa      240

gtttactgaa gcattgtcta tgtattttcc tgattttcca ttctctccaa cggaaatgag      300

atgggttgga ggaagtccaa tagattacat cgttttcaaa ggtatggata atgataagat      360

agagcaggtt gtctttctgg aaattaagag cggaaaatcg cagttgtctc ctcgggaaaa      420

gcagataaaa gaggtgattg agaaaaaagg cgttgcgtgg aggatgtatc gggctcctga      480

gcagttgacg cggggggaaa atgcagctgg tcattgatga ttttggcaca tttgtgaaaa      540

agaagcagaa ccgttttgag gttgcaagaa aggagaaaac cgaggagttc tctgcggata      600

aagtaagtca gattgtgctt ctaaaaaaag ggactatttc aggttcagca gttgcacttg      660

cgatggagaa aaatattgat gttgtctatt tagatagttt tggaaagccg attgcccgaa      720

tttttccgtg cactctgggt ggaacaactc ttatcaggag aaggcaggca gaggcaactg      780

catcactgta tgcggttccg tatgtgcgtg cgtttgtcaa gtcaaagatg ctgaatcagg      840

cggccttgct taaatcactc aataagacga gaaacggcct atttctggaa agaattcgtg      900

agattgagcg gattattgag aaatcagagg atgcagtcgg agattatgtg gatgacttgc      960

ggagtgcgtt gatagggtat gagggaaatg ttgcggcgat ttattttgac tgcatacggg     1020

cactcattcc gtttggaaga cgaaagagag gcgcaaaaga cagatttaac tctgcgttaa     1080

actacgcgta tggaattttg tattctcaaa tagagaaggc ctgtcttctt gcaggtcttg     1140

acccgtattt gggatttgtt cattctgaca ggtacggaaa accctccttg gttcttgact     1200

ttatcgagca gttcaggcaa ccgattgcag accgtgcagt tataaccatt tttgtcaaaa     1260

aagagttagc agatgattcg ttcattgaag aagaaatcgt tcagttatca tcgaaaggaa     1320

agaaaaaaat tgttgaggca atatatgggc gtctttcatc tgaattcacg cataatggga     1380

agaagatgac ttttgagaaa gtcatcatcg ataaggcaag ggaatttgca gggtgtattc     1440

ttgaaatgaa ggaatacgaa ccattcgttc acaggtggtg aaatgttata ttggctcatt     1500

tacgatattt caagcaattc caaacggttg aaagtctctg agaagtgcaa agattacggt     1560

ttataccgtg tacagaaaag tgcatttctt ggtgacctat caaagaataa ggcagaaatg     1620

cttcttgaag aagttcagga cattatggcg gaatctgaag gggactgcgt gtttatgttc     1680

cctgcgtgca aagggtgttt ttcatcaaga gcaattattg gggaatttaa tgagtcatta     1740

atcgaggaga aggagttcgt gtttttggca tgctcaagtc agtgacggca acagatgtga     1800

tgaatttttc ttactgtaag agaattcctt actatgtcca cgttttgaaa attcctcagt     1860

ttacaacggt gaaagagtat aagggacggg agaagtatga tgattttaag tataggtcca     1920

agcgttcaaa aattattcag gagtttcctc atttggaaag aaagtatgat ttgtatcttg     1980

aatgtgatgg tttttcaaca aaattggact gtgttttttt caatgatgat gacgccttcc     2040

ccttgcagct caagtatgca gtaaaaccga agaaaatgta cgcgactacg cgaaggcaat     2100

tgcttcttga ggcgttttta atcgagcaat gtcttggcaa gaaagttcaa aggggttttg     2160

tgaagtacga gttatcaggc gacttggtgg aagttgacct aactgacaag tctgaactgt     2220

tcgaaatgtt caaagaatat tttggcataa taatggggga aaaactgcct gaaccgacgg     2280

aatatttaaa aagatgccgc gattgttgtt atcgtaggtt ttgttgggga gataaatgaa     2340

gtcatttaag ctaaagttgt tgccaacaga tgagcaaaac gttcttttaa atgaagtgtt     2400

ttgtaaatgg gcatcattat gtaccagaat ggcgtctaaa ggacacgata aagaacgact     2460

ggcgcctcct gattcaagcg ggaattattt taacaaaaca caactcaatc aggtgaatac     2520

tgatgtaact gaccatatgg gtgcgcttga agagtcagca agtcaaaaag aaagagcagt     2580

tgagaaagtc aaaagaaggt tgaagctgat ttcagatatg ctctctgagc caaatttaag     2640

ggatgtttct caacaaaaac caaccacgtt ccgtccatta gagtgggtta aggagggtct     2700

gttaaaaaca aaataccata ctgtgcatta ttggcaaaag gaatgtgata agttaacaaa     2760

acaaaaagaa cgaatggaga aaacaattga gaagataaag aaagggaaga taacgttcaa     2820

accaacaaag atgtccctgc accaaaattg tttttcgtta tcattcggaa agggaacgtt     2880

ttcaatgcgg ccttttagcg acactaaacg aggcataaat cttgatatgc taactgctcc     2940

cattcaacct gcaataggaa aaaacgatgg caaatcatct ttgaggagca aagagtttat     3000

cgcaaggaat attgaaaact acattatttt ttccatccac tcacaactat ttgggctgag     3060

caggtcagaa gaactgttgt taaacgcaaa aaaagaggaa ctcgttgcta agcgagatgc     3120

aatgctcaaa aagaaatctg attcgctaag taaaaaaata aaggaattag aaaaaatagt     3180

aggaagaaaa attactgatt cagaacgttc agagataatg tctcagggcg gcaaattgtc     3240

ttctgaaaag ttcagtgaag ataattcata tttgaaaacg ttaaaggtgc tggcaaaaga     3300

cattattggg cgagaggaat tgttcagact taagaagtac ccgattgtga ttagaaaacc     3360

tctcaacgaa cgaaaaaagc tcaaaaatct taaacctgac gaatgggaat attatttaca     3420

gttgagttat gatgagttgg aaaagaaaga gtttacacca aagacaatta tgggaatcga     3480

tagaggacta aaacacattc ttgctattgc gatttacgac cctgtgcaaa ataaatttgt     3540

aaaaaatatg ctcattccaa atccgatatt aggttggaag tggaagttgc gaaagataaa     3600

aagaagtatt caacatatgg aaaggagaat acgggctcag caaaatgctc acgttcctga     3660

gaatcagttg aaaaaacggt tgaaaagtat tgagaacaaa attgattatt actatcacaa     3720

tgtgtcgcgg caaatattga atctcgctca cgatttcaaa tcagcaatag tggtagaaga     3780

cttacagaat atgaaacaac acggaagaaa gaaatcaaaa ggactaagag gactaaacta     3840

cgcattaagt aactttgact atggaaaaat tatgggtctt gttaagtata aagcagaatc     3900

agagaatgtg cctcttctta ccgtgttgcc tgcaggaacg agtcaaaatt gcgcgtattg     3960

tctcttgtac ggaaaagaac aaggaaatta tgtgcggaat aatgtcaaca gtaaaatagg     4020

caagtgtaag cttcatggag aaatagatgc ggacatcaat gcggcaagga cgattgcgat     4080

ttgttatcat aagaatatta atgaaccaaa accatatggt gaacgaaaga cttttaaaag     4140

aaagtaaatt ggaatatcct tgatgcgagg aatatgcaat catagtcctt aaggcaccgt     4200

gtatacaaac ggatatgtct tcgagcaatc gaaacatccc aaggatagca caaattctat     4260

atgggtttgt gccaaagatg gcccgttgca ggccattagg gttcataaaa cactgtcatg     4320

gtgtataacg acctgaccta ttctctactc taagaacatc tcaaccaaat aaaacagcag     4380

gtctttaaaa agggagctac aaagtcccga cctgctgttt tcatttttaa ataaaaagag     4440

aaaacgcaag tgctgttgca gatgtggaga aatagagata acgaatgcaa catcgtgatt     4500

tcttggccca tacttcctcc atgtagagcg ttgcagatgt ggagaaatag agataacgaa     4560

tgcaacgcat atatcacctt gtcatcatat tgacgacaga aaggttgcag atgtggagaa     4620

atagagataa cgaatgcaac aagtcaggac tgttaagaat gatgggtctt cttttgtcgg     4680

ttgcagatgt ggagaaatag agataacgaa tgcaactcga gataccagtg gagggtttag     4740

atgaagatac tgcacgttgc agatgtggag aaatagagat aacgaatgca acagaatttg     4800

tgcaaggcga tgggttggcg cagttttgag gttgcagatg tggagaaata gagataacga     4860

atgcaactaa ggatagaggg tgtctctgcg attgtcacga gaacagttgc agatgtggag     4920

aaatagagat aacgaatgca acatagagac tgacccgcgc tgcaagacgc gtaaggcggt     4980

tgcagatgtg gagaaataga gataacgaat gcaaccgact ggattgcttc tttctggagc     5040

tgcggcaagg ggttgcagat gtggagaaat agagataacg aatgcaacag gtactccttc     5100

caaagcccac ttcgctctcc cgtaataccg ttgcagatgt ggagaaatag agataacgaa     5160

tgcaactgcg ggagagactg attgttctgc ggcggggagt tttgttgcag atgtggagaa     5220

atagagataa cgaatgcaac tgatcccgtg aggatgaaag aaggaacgtc cacgtgttgc     5280

agatgtggag aaatagagat aacgaatgca acaggtggtt agcacgatgg agatggacag     5340

cccgcaagcg ttgcagatgt ggagaaatag agataacgaa tgcaacttct tgcagctttt     5400

ggggtgacat tgattgcgtt tggtgttgca gatgtggaga aatagagata acgaatgcaa     5460

ccggatgtaa cagctaaccc tgctacagcg acgaaaggcg ttgcagatgt ggagaaatag     5520

agataacgaa tgcaacacct tggccattgt tcagtcccag atgccatcaa gcgttgcaga     5580

tgtggagaaa tagagataac gaatgcaaca acttcttcgc ttgcgcctta cgcgccgtaa     5640

actcatgttg cagatgtgga gaaatagaga taacgaatgc aacctgtcag gcgcggacgt     5700

cctcacattg ttggccgaag ttgcagatgt ggagaaatag agataacgaa tgcaacagaa     5760

cttcgcaggc atcattaaga gcggcagcta ccagttgcag atgtggagaa atagagataa     5820

cgaatgcaac cccgaaaatg taggcaagaa tcgccgcccc aatattcgtt gcagatgtgg     5880

agaaatagag ataacgaatg caacttgttt tattttgaag cagaggataa cacgatgaag     5940

aagttgcaga tgtggagaaa tagagataac gaatgcaact aagaagggtt ttgcgagtat     6000

caaactcgtc ttttacggtt gcagatgtgg agaaatagag ataacgaatg caacttcgct     6060

tagaaatgac cgtcatcaac agatcataat gcagttgcag atgtggagaa atagagataa     6120

cgaatgcaac caaggtatat gatgcgacgg gtagtttggt gctcaatgtt gcagatgtgg     6180

agaaatagag ataacgaatg caactctcat accaaatcca cctctgcact ttttgaaaat     6240

gggttgcaga tgtggagaaa tagagataac gaatgcaaca aaaaccctct gatgaatatc     6300

gtgaccaaga gcaaaggttg cagatgtgga gaaatagaga taacgaatgc aacggaacac     6360

ctcctacgcg aaaaccctcg acgatatttg ttgcagatgt ggagaaatag agataacgaa     6420

tgcaacttca ggatgtggag cttttcgatt ttaaaccgaa gaaggttgca gatgtggaga     6480

aatagagata acgaatgcaa ctctccttga tgttgtgatt ggttccgccc tgtttgtttg     6540

ttgcagatgt ggagaaatag agataacgaa tgcaacttta tttgggcgtt gtcgattcgg     6600

agggagaggg aatggttgca gatgtggaga aatagagata acgaatgcaa cctatcgcca     6660

taactagcca cattactctt ttcaataatg ttgcagatgt ggagaaatag agataacgaa     6720

tgcaactgat gggattaatt tggtgtggca gatgctcaat gagttcagtt gcagatgtgg     6780

agaaatagag ataacgaatg caaccaaatc aatggggtcg caacgggcac tttggtgacg     6840

ttgcagatgt ggagaaatag agataacgaa tgcaacccta acgtgcgaaa cttcacccaa     6900

acattaactg tatgttgcag atgtggagaa atagagataa cgaatgcaac aacttgtgga     6960

tgggttttcc ccagatcacg gtttcgatgt tgcagatgtg gagaaataga gataacgaat     7020

gcaacaaaat atcgtacacc attatccggc gaagtgcctt acagttgcag atgtggagaa     7080

atagagataa cgaatgcaac aaactccctc cgaaaagtgg gaagtggcgg ggtgcaggtt     7140

gcagatgtgg agaaatagag ataacgaatg caacggctgg atgaaaaagc acttggtgcc     7200

tgcgtcctgc cgttgcagat gtggagaaat agagataacg aatgcaactc attgcggggc     7260

ctccttttcc agcgctttga gcgcggttgc agatgtggag aaatagagat aacgaatgca     7320

acttcttgat tgacttgact tctccggccg cctcaagaat gttgcagatg tggagaaata     7380

gagataacga atgcaacgtg agggcgggat gctttgtcga aaaatgacgg taagttgcag     7440

atgtggagaa atagagataa cgaatgcaac agtgatgctt ccccagaaga caaccaagca     7500

caccaacgcg ttgcagatgt ggagaaatag agataacgaa tgcaacctcg tcaaggttct     7560

tgtagttgaa gatgaatagc accgcgttgc agatgtggag aaatagagat aacgaatgca     7620

acaggtgccg cctcaacagc gcatcctctg gggccaagga gttgcagatg tggagaaata     7680

gagataacga atgcaacggt agaagtcgat gtcttgaacg ctgttgttgg tcacggttgc     7740

agatgtggag aaatagagat aacgaatgca acgcaaattc gggaaacctt cagccatcag     7800

cacacccccc gttgcagatg tggagaaata gagataacga atgcaactac ggccgtactg     7860

ctctcgtcaa ttccacgcct gtattggttg cagatgtgga gaaatagaga taacgaatgc     7920

aacggtgatt ggatggagtt gtatggtctt gattgtgatt tgttgcagat gtggagaaat     7980

agagataacg aatgcaacag agtcatcaga cgacggatag taaggtgtat gctgggttgc     8040

agatgtggag aaatagagat aacgaatgca actgataaaa gtcccatctt gagtacctca     8100

tccaagcagg ttgcagatgt ggagaaatag agataacgaa tgcaacgtga taagaagata     8160

ttagtgctta ctggcaggat agagttgcag atgtggagaa atagagataa cgaatgcaac     8220

taatggcgcg ccgtttttta atcgtgccgc tctcataagt tgcagatgtg gagaaataga     8280

gataacgaat gcaactcggt ttcttcaatc ttgcgtgatg cgggaattcc tcagttgcag     8340

atgtggagaa atagag                                                     8356


<210>  24
<211>  5479
<212>  DNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  24
gctgtagtgg aattcctccg cggagaccag ccccgcatcc accagctgcc tcaggttgta       60

gtgcaccgtc gagagaggga tcccgagctt ctgcgcaacc cccgattccg tggcgtcctt      120

atcggacagc acgtcgagga tcttcctgca cgactcgttg gacacggcgt tcgccacctt      180

cttcgtggcc ttgtcctcca gcgagagcat gaggaacttc ttgtctgcca tatcgggcat      240

tccggtgatt ggtttataaa tacttttgga taggtttgaa tagggttgaa gtgatgaaca      300

aaaaccactg gacagtggac aaccacgtgg atacactata taaaccgatt ttatttccct      360

atgcagatga tgttggtggt ggacaattac aagaccttca tagggaaaga aggcaaccgt      420

tttgtacttt taacggaaga gcagaagcag gagcattctg ctgatcaggt caggcagatt      480

gtcgtcgtca atggctggca atggagagca acgtggatat cgtacacctt ggcaggcggg      540

gccatcccca cgcccgcgtc tatccctgca ctcttggcgg cacgacgctc actaggagaa      600

ggcagctgga agcgtattat gcggaggaag gcacatatct ggccaagcag tttatcatgg      660

ccaagatacg caaccaggca gctctcttaa gatcgcttgg aaaatcccgg ggcaatcatt      720

ctcttctctt ctcggctaag gcaataggaa agggcaccaa tgacgttgat gcactgaaag      780

gcactattga tgaaattcgc ccgaagcttc tcggaatgga gggcaatgca agcagcgtct      840

attttggggc ccttgcagga attcttccat ttagcggcag ggacaggaat tcaaaagatc      900

cggtcaatat ccttctcaac tatggctacg gaatgctcta tggggaaatc gagcgtgcgt      960

gcgtcatcgc gggccttgac ccctatctcg ggtttatgca cacggacagg tatggcaagc     1020

cttccatgac gctggacttg atagaggaat tccggcagcc cattgtggat cgcaccctgg     1080

ttactctttt tgcgcagaag cagattgaag atgccgattt tgaggcacat ggggactccc     1140

gcctcttgag caggcagggg agggaaaaaa tcatcaaggc agtccttgag cgcctgagcc     1200

agaaagtccg tcgagcaggc gcgcaacgtc acccggtttc tccttgacag aaagcaggaa     1260

taccggggat tcacgagcag gtggtgagca tgatctactg ggtgatttac gacatcagcg     1320

caaacgggac gcgcagcaga gtggcttccg cgtgcaagaa ctacggattc aagcgcatcc     1380

agaagagcgc gtttctgggc aacatcacca aaaacaaggc ggacatgctc gccatccagt     1440

gcagggacat ggtgaaggag gaaggcgact gcgtcttcat catcccggcg tgcgagcagt     1500

gcttcagggg aaaggagata atcggggaac tcgatgagat ggcggggcgg aagctcgact     1560

acctgatagt gggggaagat ggacgacaga cagcgtctta cggcggctga cctgctcaat     1620

tactgctact gcccgcgcat tgtctattac gtgcacgtgc tgaagctggc gcaggcgacg     1680

accacaaagg aactgaaggg aagggagaag tacgatgact tcaagcggaa atccaggcgg     1740

aacaagattg tacgacgtga ctcttgagtc aaagaagcac ggcctcatca ccaaggcgga     1800

ctgcatcctc tttgacaggg agaagggcga ggcatacccc gttcagcata agtacagctt     1860

caggccgaag attctctatc acacttacat ctcccaactg atgatggagg cgatcattat     1920

cgaggagcaa ttcaatcttt ctgttcccca tggatttatc gtatttgaaa ggtcaaagga     1980

gacagtgact gttgatttgg gggacaagca gaaagtttta tatgtcgtgg ggcagataag     2040

gggaattatt gggggagaaa agttcccgcc gccgacggaa tggaaaaagc ggtgcgtgga     2100

ctgctgctat aacaagctgt gttgggggta agatggctaa gaatactatt acaaaaactc     2160

tgaaactgag aatagttcga ccatataatt ctgctgaagt agagaagata gtagctgatg     2220

agaaaaacaa tagggagaaa atcgccttag aaaaaaataa ggataaggtt aaagaggcct     2280

gtagcaagca tctcaaagtt gccgcctatt gcacgacgca agtagaaaga aatgcatgcc     2340

ttttctgcaa agcaagaaaa ttagacgata agttctacca aaagctgagg ggacaatttc     2400

ctgatgctgt attttggcaa gagatttctg agatattcag gcaattgcag aagcaagctg     2460

ctgaaatata taatcaaagt ctcatcgaac tatattacga gatttttata aagggaaaag     2520

gaattgcaaa tgcttcatca gttgagcatt atctcagtga tgtttgttat acaagagctg     2580

ccgaattatt caaaaatgct gcgatagcaa gcggtttaag atcaaagata aagagcaatt     2640

tcaggctcaa ggaattaaaa aatatgaaat cagggcttcc gactacaaaa tcagacaact     2700

tccccattcc tcttgtcaag cagaaaggag ggcaatatac cggctttgag atttcaaatc     2760

ataattctga tttcatcata aaaattccgt ttggcagatg gcaagtgaaa aaagagattg     2820

ataaatacag gccttgggaa aagtttgatt ttgaacaagt gcagaagtct cctaaaccca     2880

tctctctctt gctgtccacg cagagaagaa aaagaaacaa agggtggtcc aaagatgagg     2940

gtactgaggc agaaataaag aaagtgatga atggagatta ccaaacaagc tatattgagg     3000

taaaaagagg atcgaaaatt ggggagaaga gtgcttggat gcttaatctt tctatcgatg     3060

tccccaagat cgacaaggga gttgatccgt ccattatagg cggaatcgat gtcggcgtga     3120

aaagcccgct tgtgtgcgct atcaacaatg ctttcagtcg ttactctatc tcggacaatg     3180

acctctttca tttcaacaaa aaaatgttcg ccagaaggag gatattgctt aagaagaata     3240

ggcataaaag agcaggacat ggtgctaaaa ataaacttaa gcctatcacc atattaactg     3300

aaaaaagcga gagatttagg aagaaactaa tcgagaggtg ggcgtgcgag attgcagatt     3360

ttttcatcaa aaataaggtt ggaactgtcc aaatggaaaa tttggagtcc atgaagagaa     3420

aagaagacag ctacttcaac atcagattga gaggtttttg gccttatgca gaaatgcaaa     3480

ataaaataga atttaagctc aaacagtatg gtatagaaat aagaaaagta gcgcctaaca     3540

atacctctaa aacgtgctcc aaatgtggtc accttaataa ctattttaat tttgaataca     3600

gaaaaaagaa caaatttcct catttcaagt gtgaaaagtg caatttcaag gaaaatgcgg     3660

attataacgc cgctttaaat atttccaatc caaaactaaa atcaacaaag gaagaaccat     3720

agatatttat actttattat ccttcattga caaaaatgag aatgttatcc cagataacat     3780

ttgatgtaca cagattcaca cttcactgat aaagtggaga accgcttcac caaaagctgt     3840

cccttagggg attagaactt gagtgaaggt gggctgcttg catcagccta atgtcgagaa     3900

gtgctttctt cggaaagtaa ccctcgaaac aaattcattt ttcctctcca attctgcaca     3960

aaaaaaggtg agtccttata aaccggcgtg cagaacgccg gctcaccttt tttcttcatt     4020

cgattttatg cttaaaagcc gtaaaaacgc ggaattcggc gccgttgcag aacccgaata     4080

gacgaatgaa ggaatgcaac catactctgc cttagtgttg gtgcaataat gtatagttgc     4140

agaacccgaa tagacgaatg aaggaatgca actacacctc aagcaagcat ccttccagta     4200

atacaaagtt gcagaacccg aatagacgaa tgaaggaatg caacaatcaa acaaacatct     4260

aacggcaatc caattcttgt tgcagaaccc gaatagacga atgaaggaat gcaactggaa     4320

tggaacaagc ccagatacaa acaaaacatt gttgcagaac ccgaatagac gaatgaagga     4380

atgcaacttg aatcccacca atccttccct aatttttggt tgtagagttg cagaacccga     4440

atagacgaat gaaggaatgc aactcgactt cctgcgtgga aagcagggag acagaatgtt     4500

gcagaacccg aatagacgaa tgaaggaatg caacctccca tttaggaatg aaaacgcggg     4560

catagttcgt tgcagaaccc gaatagacga atgaaggaat gcaacacaat atacccccac     4620

tagatgggtt tgcatagctt agttgcagaa cccgaataga cgaatgaagg aatgcaaccg     4680

taagttattg cttcatggct tcccaagagg gagttgcaga acccgaatag acgaatgaag     4740

gaatgcaact caacaccaac agcatctccg tgaaagatag tgtcgttgca gaacccgaat     4800

agacgaatga aggaatgcaa ccaacaacag cgaccgaggg cggccactgt cgatgtgttg     4860

cagaacccga atagacgaat gaaggaatgc aacctgcgcc agccgttgag ttaaatccgg     4920

caaggagttg cagaacccga atagacgaat gaaggaatgc aacatgatct cctggccgac     4980

gtaaagcgtc aatcgttgct tgttgcagaa cccgaataga cgaatgaagg aatgcaactt     5040

tttgccttta cttctgcgtc gtatgacatc ttgttgcaga acccgaatag acgaatgaag     5100

gaatgcaaca acagagtccc gaataatcca gactttgagg caagttgcag aacccgaata     5160

gacgaatgaa ggaatgcaac tgggaagccg cttcctgaca tctcaaagca agtctgttgc     5220

agaacccgaa tagacgaatg aaggaatgca acgagatgga aaaggttaat cttcgtcagg     5280

aatatattgt tgcagaaccc gaatagacga atgaaggaat gcaatcttga cagagcccga     5340

ttgcgttatc tccaggagaa acatataaaa gcatcaaccg ctgatcggaa tgatatccaa     5400

aaacatggcc accatcaccc gatggattga ggagcgggca cgatattcca cccccatcat     5460

ccgcatctcc cttgccctc                                                  5479


<210>  25
<211>  1842
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  25
atgatttcac tcaaacttaa actgcttcca gacgaagaac aaaagaaatt gcttgacgaa       60

atgttttgga agtgggcctc gatttgtacc cgcgttggtt ttgggcgggc tgataaagaa      120

gatttaaaac cgccaaaaga cgcggaaggg gtttggttta gtttaacaca attaaatcaa      180

gccaacacag acattaacga cttaagggag gcgatgaagc accaaaaaca ccgcctagaa      240

tacgaaaaaa accgtttgga agcgcaaaga gatgatactc aggatgcctt gaaaaatccg      300

gacagacgag aaataagcac taaaagaaag gatttattcc gtcccaaagc gtccgtcgaa      360

aaaggctttc tgaaactgaa gtatcatcaa gagcgttatt gggttcgaag gctgaaagaa      420

ataaacaaac taattgaaag gaaaacgaag acacttataa aaatagaaaa ggggcgaatc      480

aaattcaagg caacgcgaat aaccctgcac caaggctctt ttaaaattag attcggcgat      540

aaacccgctt ttctgataaa ggcgttgtct ggaaaaaacc aaatagacgc tccttttgtt      600

gtagtgccag aacaaccaat ctgcgggagc gttgtaaata gcaagaaata cttagatgaa      660

attactacta atttcttggc ttacagcgta aatgcaatgc ttttcggttt gagccgcagc      720

gaggaaatgt tgttgaaagc caaaaggcca gaaaaaatca agaaaaaaga agaaaaactt      780

gctaaaaaac aatcagcctt tgaaaacaaa aagaaggaat tgcaaaaatt acttggtaga      840

gaactaaccc agcaggaaga agcgattatt gaagaaaccc gcaaccaatt ctttcaagat      900

tttgaggtga aaataaccaa acaatactcg gaattactca gcaaaattgc taacgaactc      960

aagcaaaaaa atgattttct gaaagtaaac aaatatccta tacttttaag gaaacctctc     1020

aagaaagcca aatcgaaaaa aattaataat ctttcgccaa gcgaatggaa atattacctc     1080

caattcggag ttaaaccttt actaaaacaa aaatcaagac gaaaatcaag gaatgttttg     1140

ggaatagacc gcggccttaa acacttgcta gccgtaaccg ttcttgaacc cgacaaaaaa     1200

acgtttgtat ggaacaaact ttacccaaac ccaattacgg gctggaagtg gaggcgacgc     1260

aagcttttgc gctccttaaa gcgattgaag aggcgcatta aatcgcaaaa acacgaaaca     1320

attcatgaaa accaaacgag gaaaaagctc aagagtttac aaggcaggat agatgacctg     1380

cttcataata tttccagaaa aatagtggag accgcaaaag aatatgatgc ggtaatagta     1440

gtggaagacc tccaaagcat gcggcaacac ggtcgttcaa aaggcaatcg tttgaaaaca     1500

ctgaattacg cgctaagcct tttcgattac gcaaacgtga tgcaacttat aaagtacaag     1560

gcgggtatag aaggaatcca aatatatgac gttaaaccag ctggcacaag ccaaaattgc     1620

gcgtattgcc ttttagcgca aagggattca cacgaataca aaagaagcca agaaaactcc     1680

aaaataggtg tttgcttaaa tcctaactgc caaaaccaca agaaacaaat tgacgctgac     1740

ctaaacgcgg caagagtaat agctagttgt tacgccttaa aaattaatga ttcccaacca     1800

tttggaacaa ggaaaagatt taaaaaaaga acaacgaatt aa                        1842


<210>  26
<211>  1503
<212>  DNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  26
atggaagtac aaaaaactgt gatgaagaca ctttctttga gaatattaag acctctgtac       60

tcacaagaaa tagaaaaaga gattaaagaa gaaaaagaaa gaagaaaaca agccggagga      120

actggagagc ttgacggggg attttataaa aagcttgaga agaagcattc agagatgttc      180

agctttgata ggttaaactt attgttgaat caattacaaa gagaaattgc taaggtctac      240

aatcatgcca tcagtgaatt gtatatagcg actatcgctc aaggtaacaa gagcaacaaa      300

cattatatta gtagtattgt ctataatcga gcatatggat acttttataa cgcttacata      360

gccttaggga tatgttcaaa agttgaagca aattttagat ccaatgaact cctaacacaa      420

caaagcgcat tgcctacagc aaagtcagat aattttccaa tagttttaca taaacaaaaa      480

ggtgctgagg gagaggatgg aggatttagg atatctactg aggggagcga tctgatattt      540

gagataccca ttccgttcta tgaatataat ggggagaacc gaaaagaacc ctataaatgg      600

gttaaaaaag gaggacaaaa acctgtgtta aaacttatac tttctacttt taggagacaa      660

agaaataagg ggtgggcaaa agacgagggc acggatgcgg aaataagaaa ggttacagaa      720

gggaagtatc aagtcagcca aatagaaata aataggggta aaaaactagg agaacatcaa      780

aaatggtttg ccaatttcag catagagcaa ccaatttatg aaagaaaacc taatcggagt      840

attgtcggcg gattagacgt gggaataaga tcccccctag tatgtgcaat taacaactca      900

ttttcgagat attctgttga ttccaatgat gtatttaagt tttctaaaca agtattcgca      960

tttagaagac ggctattatc gaaaaactct ttgaaaagga aaggtcatgg ggcggctcat     1020

aagttagaac ctatcacgga aatgacagaa aaaaatgaca agtttagaaa gaaaataatt     1080

gagagatggg ccaaggaagt tacaaatttc tttgttaaaa accaagtagg aattgttcag     1140

atagaagatt tatcaacgat gaaagacaga gaggatcatt tttttaatca atatcttaga     1200

ggattttggc cttattacca aatgcagaca ttaattgaga acaagctcaa agagtatggg     1260

attgaggtaa aaagggtaca ggcaaaatat acgtctcagt tgtgctcaaa ccctaattgc     1320

aggtattgga ataactattt taactttgaa taccgaaaag taaataaatt cccaaaattt     1380

aaatgtgaaa agtgtaactt agaaataagt gctgactata acgctgctcg caatctatca     1440

actcccgata tagagaaatt tgtggcaaaa gctacaaaag gcattaattt gccagaaaaa     1500

tga                                                                   1503


<210>  27
<211>  1275
<212>  DNA
<213>  Parageobacillus thermoglucosidasius

<400>  27
atgaagtata cgaaagtaat gaggtatcaa attatcaaac ccttaaacgc agaatgggat       60

gaattgggaa tggttctccg tgacatccag aaagaaactc gcgcggcatt aaacaagacg      120

attcaattgt gttgggaata tcaaggattt agtgcggatt ataagcagat acacggtcag      180

tatcctaaac caaaagatgt tttaggatac acaagtatgc acggatatgc ttatgatcgt      240

ctcaaaaatg aattcagcaa aattgcaagt tcaaaccttt cgcaaactat caaacgagcg      300

gtagataaat ggaatagtga cttaaaagaa attctgcgtg gtgaccgctc catccctaac      360

ttcagaaaag attgtccaat tgatatcgtt aagcaatcga cgaaaataca aaaatgtaat      420

gatggatacg tattaagcct cggtttaatt aatagagagt ataaaaatga attgggacgg      480

aaaaacggag tatttgatgt acttataaaa gcaaacgata aaacccagca aaccatatta      540

gaacgaatta taaatggcga ttatacatat acggcatctc aaataatcaa tcataaaaat      600

aagtggttta ttaaccttac ctatcaattt gaaactaaag aaacagcctt agatcccaat      660

aatgtcatgg gagttgatct aggaattgtt tatcctgttt atatagcatt taataacagt      720

cttcaccgtt atcatattaa aggaggagaa atagaacgat tcagacggca agtagaaaaa      780

aggaagaggg aattgttaaa tcaaggcaaa tattgtggag acgggcgtaa agggcatggt      840

tatgctacaa gaacaaagtc cattgaatca attagcgata aaattgcgag atttcgtgac      900

acttgcaatc ataaatattc caggtttatt gtagatatgg cgcttaaaca taattgtggg      960

ataattcaaa tggaagattt gactggaatt agcaaggaaa gtacattttt gaaaaattgg     1020

acatattacg atcttcagca gaaaatcgaa tataaggcac gagaagcagg aatacaagtt     1080

ataaaaattg aaccccaata tacatctcaa cgttgtagta aatgtggcta tattgataaa     1140

gagaatcggc aagaacaagc tacatttaag tgcatcgaat gtggttttaa gacaaatgct     1200

gactataatg cagcaaggaa tatcgcaata ccgaacattg acaagataat aaggaaaacg     1260

ttaaaaatgc aataa                                                      1275


<210>  28
<211>  1269
<212>  DNA
<213>  Acidibacillus sulfuroxidans

<400>  28
atgatcaaag tatatcggta tgagatcgta aaaccgcttg atttagattg gaaagagttt       60

ggaactattt tacgacagtt acaacaggaa actcgttttg ccttaaacaa agcgactcaa      120

ctggcttggg aatggatggg ctttagtagt gattataagg ataatcatgg ggaatatcca      180

aaaagtaaag acattctcgg atacacgaat gttcacggat acgcttacca tacgatcaaa      240

accaaagcat atcgcttaaa cagtggtaat ttatctcaaa ccatcaaacg tgcgacggat      300

cgttttaaag catatcaaaa ggaaatctta cgtggcgata tgtccattcc gtcctataaa      360

cgagatattc cactcgatct gattaaagag aatatcagcg taaatcgtat gaatcacggg      420

gattatatcg cttcgttatc tctgttaagc aatccagcca agcaagaaat gaatgtaaag      480

aggaaaattt cggtcataat cattgtccgt ggcgcaggga aaacaatcat ggacagaatc      540

ctaagtggtg aataccaagt ctctgcttca caaataattc acgatgatcg aaaaaacaaa      600

tggtatttaa acataagtta tgattttgaa ccccaaaccc gagtgttgga tctaaataaa      660

ataatgggga ttgatttagg cgttgctgtt gccgtttaca tggcatttca acatacccct      720

gctcgataca aattggaggg aggtgagatt gaaaattttc gtagacaggt agaatctcga      780

cggattagta tgttacgtca aggtaaatat gccggtggtg cccgtggagg gcatgggcga      840

gataaaagaa taaaaccgat tgaacagctt cgagataaaa ttgctaattt tagagatacc      900

acaaaccatc gttatagtag atatatagtg gatatggcaa ttaaagaagg ttgtggaacg      960

attcagatgg aggatttaac gaatatacgc gatattggat ctcgattttt acaaaattgg     1020

acctattatg atttgcagca aaaaattatt tataaagccg aagaggcagg aattaaagtc     1080

ataaagatcg atccccaata taccagtcaa cgttgtagtg aatgtggtaa tatagattcc     1140

gggaatcgaa ttggacaagc tatctttaaa tgcagagctt gcggatacga agccaatgca     1200

gactacaatg ctgcacgaaa catagcaata ccgaacattg acaaaattat agctgagagt     1260

atcaaataa                                                             1269


<210>  29
<211>  1323
<212>  DNA
<213>  Ruminococcus sp.

<400>  29
ctggtcaaag tcgtaaaaat ccatctaatt agtgagcaat ttgacaaagc aggcaaccgg       60

atagattatg aagaagtcaa taaaatactg tgggaattgc aaaagcagac acgagaagca      120

aagaataaaa ctgttcagct tctttgggaa tggaacaatt tttcaagcga ttatgttaag      180

gcgagtggca tatatcctaa agcaaaagac atatttggct actcaagtgt gcatggacaa      240

gcaaacaaag aattaagaac aaaactcgct ttaaattcaa gtaatctttc cactaccaca      300

atggacgtat gtaaaaattt taatacatat aaaaaagagg tatggaaagg caaacgatca      360

gttccttcgt acaaatcaga ccaacctctt gatctgcaca aagactctat aaagctgata      420

tatgaaaaca acgaatttta tgttaggctc gctttattaa aaaaagctga atttgcaaag      480

tatggtttta aagacggttt tcgttttaaa atgcaggtga aagataattc taccaaaact      540

attcttgaac gctgttttga cgaagtatac aaaataaatg ccagcaaact tttatatgac      600

caaaagaaaa agaagtggaa gcttaatctg tcttatagtt tcgacaataa aaacatttct      660

gaacttgaca aagaaaagat ccttggtgtt gatgtaggcg ttaactgtcc tttagtcgct      720

tcggttttcg gcgatcgtga ccgattcata atcaagggcg gcgaaattga aaaattcaga      780

aaaagcgtgg aagctcgcag acgttcaatg ctcgagcaaa caaaatactg cggtgacgga      840

agaattggtc acggcagaaa aaaacgcact gagcctgccc taaatatagg cgacaagata      900

gcaagatttc gtgatacaac aaaccacaaa tacagcagag ctttgataga atatgctgta      960

aaaaagggct gcggaactat ccaaatggaa aagctgacgg gtattacatc taaatctgat     1020

cgttttctaa aagactggac ttattatgac ctccagacaa agatagaaaa caaggcgaaa     1080

gaagtaggga taaatgtcgt ctatatcgcc cctaaatata caagtcagag atgtagcaaa     1140

tgcggatata tccacaagga taacagacca aatcaggcga aatttagatg tcttgaatgc     1200

gattttgaaa gtaatgcaga ttataatgca agtcagaata tcggaattaa aaacattgat     1260

aagataatag aaaaagattt gcaaaagcaa gaaagcgaag tccaagtgaa cgaaaacaag     1320

tag                                                                   1323


<210>  30
<211>  1494
<212>  DNA
<213>  Syntrophomonas palmitatica

<400>  30
atgggcgaat cggtaaaagc aataaaatta aagatactgg atatgttttt agaccccgaa       60

tgcacaaagc aggatgataa ctggcgcaaa gatttgtcta ctatgtccag attctgcgct      120

gaagcgggga atatgtgtct gcgcgacctg tataattact tttcaatgcc caaggaagac      180

cgtatttcct caaaagactt atataacgct atgtatcata aaactaaact tctccatcct      240

gaattaccag gtaaggtagc gaaccaaata gtaaaccacg ctaaagatgt ttggaaacgc      300

aacgctaaac tcatttatcg gaaccaaatc tcaatgccta catataagat aacaacagca      360

ccaatccggc tgcaaaataa catttataaa ttaataaaaa ataagaacaa atacataata      420

gacgtacagt tatactccaa ggaatactcc aaggatagtg gtaaaggcac tcataggtat      480

tttctggtag cagttagaga ctcatcaacc cgtatgatat tcgaccgtat tatgagtaag      540

gaccatattg acagtagtaa atcatacacg caaggacaac tccaaatcaa gaaagaccac      600

caggggaaat ggtattgcat cataccctat acattcccta cacatgagac agtcctcgac      660

cctgataaag tcatgggagt agaccttggc gttgcaaaag ctgtttactg ggcgtttaat      720

agttcttata aaagaggctg tatcgacggt ggggaaatag aacatttccg caaaatgata      780

cgagctcgca gggtgtccat ccaaaatcaa atcaaacatt caggggacgc ccgtaaagga      840

catgggcgca aaagggcgtt aaaacccata gaaacattga gcgagaagga aaagaatttt      900

agggatacaa taaaccaccg ctatgcaaat cgaattgtag aagctgctat taagcaaggc      960

tgtgggacaa tccaaatcga aaaccttgaa ggtatagctg acacaacagg cagtaaattt     1020

ctcaagaact ggccttatta cgacctgcag acaaaaattg ttaataaagc caaggaacat     1080

ggcattaccg ttgttgcaat aaacccccaa tatacatccc aaaggtgttc gatgtgcggg     1140

tatattgaaa aaaccaaccg ttcatcacag gcagtatttg aatgtaaaca atgcggttac     1200

ggcagtagga ctatatgtat taactgcagg cacgtccaag tatccgggga tgtttgtgag     1260

gaatgtggcg gcatagtaaa aaaagaaaac gtaaacgcag actacaatgc ggcaaaaaac     1320

atatccacac cgtacatcga ccagataata atggagaagt gtttagaact aggtattcct     1380

taccgcagta taacctgtaa agaatgtggt cacatacagg cttcaggaaa tacctgcgag     1440

gtttgcggaa gtactaatat tttgaaacca aagaaaatta gaaaagcaaa ataa           1494


<210>  31
<211>  1494
<212>  DNA
<213>  Clostridium novyi

<400>  31
atgattacag ttagaaaaat aaagttaaca ataatgggag ataaagatac aagaaatagt       60

caatacaaat ggattagaga tgaacaatac aatcagtaca gagctttaaa tatgggtatg      120

acttatttag ctgtaaatga tattttatat atgaatgaaa gcggattaga aattcgaact      180

attaaagatt taaaagattg tgaaaaagat attgataaaa ataaaaaaga aattgaaaag      240

ttaactgcaa gactagagaa ggaacaaaat aagaaaaatt cctcatcaga aaaattagat      300

gagattaaat ataaaataag tttagtagaa aataaaattg aagattataa attaaaaata      360

gttgagttaa ataaaattct tgaagaaaca caaaaagaaa gaatggatat acagaaagaa      420

tttaaagaaa aatatgtaga tgatctttat caagttttag ataaaatacc ctttaagcat      480

ttagacaata aaagtctagt tactcaaaga ataaaagctg atataaagtc agataaaagt      540

aatggactat taaaaggtga aagaagtatt agaaactaca agagaaactt tcctttaatg      600

actagaggac gagatttaaa atttaaatat gatgataatg atgatattga aataaagtgg      660

atggaaggaa ttaaatttaa agttattttg ggaaatagaa taaaaaattc cttagagctt      720

agacacactt tacataaagt tatagaggga aaatataaaa tatgtgatag tagtttgcaa      780

tttgataaaa ataataatct tatacttaat ttaactctag acattcctat tgatattgta      840

aataaaaaag tttcaggaag agttgtagga gtagatttag gattaaagat accagcatat      900

tgtgcattaa atgatgttga atatattaaa aaatctatag gacgtataga tgatttcttg      960

aaagttagaa ctcaaatgca gagtagaaga agaagacttc aaattgcaat acaaagtgct     1020

aaaggtggaa aaggtagggt gaataaactt caagccttgg agagatttgc tgaaaaggag     1080

aagaattttg caaagacata taatcatttt ttaagttcta atatagttaa atttgcagtt     1140

agcaatcagg ccgaacaaat taatatggag ttattaagtt taaaagaaac tcaaaataag     1200

tcaatactaa gaaattggag ttattatcaa cttcaaacaa tgattgagta taaagcccaa     1260

cgtgaaggga ttaaagttaa gtacatagat ccttatcata catcacaaac atgtagtaaa     1320

tgtggtaatt atgaagaagg acaaagagaa tctcaagctg attttatatg caaaaaatgt     1380

ggttataaag ttaatgctga ttataatgca gctagaaata tcgctatgag taataaatat     1440

ataacaaaaa aagaagaaag taagtattac aaaattaaag aaagtatggt ataa           1494


<210>  32
<211>  613
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  32

Met Ile Ser Leu Lys Leu Lys Leu Leu Pro Asp Glu Glu Gln Lys Lys 
1               5                   10                  15      


Leu Leu Asp Glu Met Phe Trp Lys Trp Ala Ser Ile Cys Thr Arg Val 
            20                  25                  30          


Gly Phe Gly Arg Ala Asp Lys Glu Asp Leu Lys Pro Pro Lys Asp Ala 
        35                  40                  45              


Glu Gly Val Trp Phe Ser Leu Thr Gln Leu Asn Gln Ala Asn Thr Asp 
    50                  55                  60                  


Ile Asn Asp Leu Arg Glu Ala Met Lys His Gln Lys His Arg Leu Glu 
65                  70                  75                  80  


Tyr Glu Lys Asn Arg Leu Glu Ala Gln Arg Asp Asp Thr Gln Asp Ala 
                85                  90                  95      


Leu Lys Asn Pro Asp Arg Arg Glu Ile Ser Thr Lys Arg Lys Asp Leu 
            100                 105                 110         


Phe Arg Pro Lys Ala Ser Val Glu Lys Gly Phe Leu Lys Leu Lys Tyr 
        115                 120                 125             


His Gln Glu Arg Tyr Trp Val Arg Arg Leu Lys Glu Ile Asn Lys Leu 
    130                 135                 140                 


Ile Glu Arg Lys Thr Lys Thr Leu Ile Lys Ile Glu Lys Gly Arg Ile 
145                 150                 155                 160 


Lys Phe Lys Ala Thr Arg Ile Thr Leu His Gln Gly Ser Phe Lys Ile 
                165                 170                 175     


Arg Phe Gly Asp Lys Pro Ala Phe Leu Ile Lys Ala Leu Ser Gly Lys 
            180                 185                 190         


Asn Gln Ile Asp Ala Pro Phe Val Val Val Pro Glu Gln Pro Ile Cys 
        195                 200                 205             


Gly Ser Val Val Asn Ser Lys Lys Tyr Leu Asp Glu Ile Thr Thr Asn 
    210                 215                 220                 


Phe Leu Ala Tyr Ser Val Asn Ala Met Leu Phe Gly Leu Ser Arg Ser 
225                 230                 235                 240 


Glu Glu Met Leu Leu Lys Ala Lys Arg Pro Glu Lys Ile Lys Lys Lys 
                245                 250                 255     


Glu Glu Lys Leu Ala Lys Lys Gln Ser Ala Phe Glu Asn Lys Lys Lys 
            260                 265                 270         


Glu Leu Gln Lys Leu Leu Gly Arg Glu Leu Thr Gln Gln Glu Glu Ala 
        275                 280                 285             


Ile Ile Glu Glu Thr Arg Asn Gln Phe Phe Gln Asp Phe Glu Val Lys 
    290                 295                 300                 


Ile Thr Lys Gln Tyr Ser Glu Leu Leu Ser Lys Ile Ala Asn Glu Leu 
305                 310                 315                 320 


Lys Gln Lys Asn Asp Phe Leu Lys Val Asn Lys Tyr Pro Ile Leu Leu 
                325                 330                 335     


Arg Lys Pro Leu Lys Lys Ala Lys Ser Lys Lys Ile Asn Asn Leu Ser 
            340                 345                 350         


Pro Ser Glu Trp Lys Tyr Tyr Leu Gln Phe Gly Val Lys Pro Leu Leu 
        355                 360                 365             


Lys Gln Lys Ser Arg Arg Lys Ser Arg Asn Val Leu Gly Ile Asp Arg 
    370                 375                 380                 


Gly Leu Lys His Leu Leu Ala Val Thr Val Leu Glu Pro Asp Lys Lys 
385                 390                 395                 400 


Thr Phe Val Trp Asn Lys Leu Tyr Pro Asn Pro Ile Thr Gly Trp Lys 
                405                 410                 415     


Trp Arg Arg Arg Lys Leu Leu Arg Ser Leu Lys Arg Leu Lys Arg Arg 
            420                 425                 430         


Ile Lys Ser Gln Lys His Glu Thr Ile His Glu Asn Gln Thr Arg Lys 
        435                 440                 445             


Lys Leu Lys Ser Leu Gln Gly Arg Ile Asp Asp Leu Leu His Asn Ile 
    450                 455                 460                 


Ser Arg Lys Ile Val Glu Thr Ala Lys Glu Tyr Asp Ala Val Ile Val 
465                 470                 475                 480 


Val Glu Asp Leu Gln Ser Met Arg Gln His Gly Arg Ser Lys Gly Asn 
                485                 490                 495     


Arg Leu Lys Thr Leu Asn Tyr Ala Leu Ser Leu Phe Asp Tyr Ala Asn 
            500                 505                 510         


Val Met Gln Leu Ile Lys Tyr Lys Ala Gly Ile Glu Gly Ile Gln Ile 
        515                 520                 525             


Tyr Asp Val Lys Pro Ala Gly Thr Ser Gln Asn Cys Ala Tyr Cys Leu 
    530                 535                 540                 


Leu Ala Gln Arg Asp Ser His Glu Tyr Lys Arg Ser Gln Glu Asn Ser 
545                 550                 555                 560 


Lys Ile Gly Val Cys Leu Asn Pro Asn Cys Gln Asn His Lys Lys Gln 
                565                 570                 575     


Ile Asp Ala Asp Leu Asn Ala Ala Arg Val Ile Ala Ser Cys Tyr Ala 
            580                 585                 590         


Leu Lys Ile Asn Asp Ser Gln Pro Phe Gly Thr Arg Lys Arg Phe Lys 
        595                 600                 605             


Lys Arg Thr Thr Asn 
    610             


<210>  33
<211>  500
<212>  PRT
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  33

Met Glu Val Gln Lys Thr Val Met Lys Thr Leu Ser Leu Arg Ile Leu 
1               5                   10                  15      


Arg Pro Leu Tyr Ser Gln Glu Ile Glu Lys Glu Ile Lys Glu Glu Lys 
            20                  25                  30          


Glu Arg Arg Lys Gln Ala Gly Gly Thr Gly Glu Leu Asp Gly Gly Phe 
        35                  40                  45              


Tyr Lys Lys Leu Glu Lys Lys His Ser Glu Met Phe Ser Phe Asp Arg 
    50                  55                  60                  


Leu Asn Leu Leu Leu Asn Gln Leu Gln Arg Glu Ile Ala Lys Val Tyr 
65                  70                  75                  80  


Asn His Ala Ile Ser Glu Leu Tyr Ile Ala Thr Ile Ala Gln Gly Asn 
                85                  90                  95      


Lys Ser Asn Lys His Tyr Ile Ser Ser Ile Val Tyr Asn Arg Ala Tyr 
            100                 105                 110         


Gly Tyr Phe Tyr Asn Ala Tyr Ile Ala Leu Gly Ile Cys Ser Lys Val 
        115                 120                 125             


Glu Ala Asn Phe Arg Ser Asn Glu Leu Leu Thr Gln Gln Ser Ala Leu 
    130                 135                 140                 


Pro Thr Ala Lys Ser Asp Asn Phe Pro Ile Val Leu His Lys Gln Lys 
145                 150                 155                 160 


Gly Ala Glu Gly Glu Asp Gly Gly Phe Arg Ile Ser Thr Glu Gly Ser 
                165                 170                 175     


Asp Leu Ile Phe Glu Ile Pro Ile Pro Phe Tyr Glu Tyr Asn Gly Glu 
            180                 185                 190         


Asn Arg Lys Glu Pro Tyr Lys Trp Val Lys Lys Gly Gly Gln Lys Pro 
        195                 200                 205             


Val Leu Lys Leu Ile Leu Ser Thr Phe Arg Arg Gln Arg Asn Lys Gly 
    210                 215                 220                 


Trp Ala Lys Asp Glu Gly Thr Asp Ala Glu Ile Arg Lys Val Thr Glu 
225                 230                 235                 240 


Gly Lys Tyr Gln Val Ser Gln Ile Glu Ile Asn Arg Gly Lys Lys Leu 
                245                 250                 255     


Gly Glu His Gln Lys Trp Phe Ala Asn Phe Ser Ile Glu Gln Pro Ile 
            260                 265                 270         


Tyr Glu Arg Lys Pro Asn Arg Ser Ile Val Gly Gly Leu Asp Val Gly 
        275                 280                 285             


Ile Arg Ser Pro Leu Val Cys Ala Ile Asn Asn Ser Phe Ser Arg Tyr 
    290                 295                 300                 


Ser Val Asp Ser Asn Asp Val Phe Lys Phe Ser Lys Gln Val Phe Ala 
305                 310                 315                 320 


Phe Arg Arg Arg Leu Leu Ser Lys Asn Ser Leu Lys Arg Lys Gly His 
                325                 330                 335     


Gly Ala Ala His Lys Leu Glu Pro Ile Thr Glu Met Thr Glu Lys Asn 
            340                 345                 350         


Asp Lys Phe Arg Lys Lys Ile Ile Glu Arg Trp Ala Lys Glu Val Thr 
        355                 360                 365             


Asn Phe Phe Val Lys Asn Gln Val Gly Ile Val Gln Ile Glu Asp Leu 
    370                 375                 380                 


Ser Thr Met Lys Asp Arg Glu Asp His Phe Phe Asn Gln Tyr Leu Arg 
385                 390                 395                 400 


Gly Phe Trp Pro Tyr Tyr Gln Met Gln Thr Leu Ile Glu Asn Lys Leu 
                405                 410                 415     


Lys Glu Tyr Gly Ile Glu Val Lys Arg Val Gln Ala Lys Tyr Thr Ser 
            420                 425                 430         


Gln Leu Cys Ser Asn Pro Asn Cys Arg Tyr Trp Asn Asn Tyr Phe Asn 
        435                 440                 445             


Phe Glu Tyr Arg Lys Val Asn Lys Phe Pro Lys Phe Lys Cys Glu Lys 
    450                 455                 460                 


Cys Asn Leu Glu Ile Ser Ala Asp Tyr Asn Ala Ala Arg Asn Leu Ser 
465                 470                 475                 480 


Thr Pro Asp Ile Glu Lys Phe Val Ala Lys Ala Thr Lys Gly Ile Asn 
                485                 490                 495     


Leu Pro Glu Lys 
            500 


<210>  34
<211>  424
<212>  PRT
<213>  Parageobacillus thermoglucosidasius

<400>  34

Met Lys Tyr Thr Lys Val Met Arg Tyr Gln Ile Ile Lys Pro Leu Asn 
1               5                   10                  15      


Ala Glu Trp Asp Glu Leu Gly Met Val Leu Arg Asp Ile Gln Lys Glu 
            20                  25                  30          


Thr Arg Ala Ala Leu Asn Lys Thr Ile Gln Leu Cys Trp Glu Tyr Gln 
        35                  40                  45              


Gly Phe Ser Ala Asp Tyr Lys Gln Ile His Gly Gln Tyr Pro Lys Pro 
    50                  55                  60                  


Lys Asp Val Leu Gly Tyr Thr Ser Met His Gly Tyr Ala Tyr Asp Arg 
65                  70                  75                  80  


Leu Lys Asn Glu Phe Ser Lys Ile Ala Ser Ser Asn Leu Ser Gln Thr 
                85                  90                  95      


Ile Lys Arg Ala Val Asp Lys Trp Asn Ser Asp Leu Lys Glu Ile Leu 
            100                 105                 110         


Arg Gly Asp Arg Ser Ile Pro Asn Phe Arg Lys Asp Cys Pro Ile Asp 
        115                 120                 125             


Ile Val Lys Gln Ser Thr Lys Ile Gln Lys Cys Asn Asp Gly Tyr Val 
    130                 135                 140                 


Leu Ser Leu Gly Leu Ile Asn Arg Glu Tyr Lys Asn Glu Leu Gly Arg 
145                 150                 155                 160 


Lys Asn Gly Val Phe Asp Val Leu Ile Lys Ala Asn Asp Lys Thr Gln 
                165                 170                 175     


Gln Thr Ile Leu Glu Arg Ile Ile Asn Gly Asp Tyr Thr Tyr Thr Ala 
            180                 185                 190         


Ser Gln Ile Ile Asn His Lys Asn Lys Trp Phe Ile Asn Leu Thr Tyr 
        195                 200                 205             


Gln Phe Glu Thr Lys Glu Thr Ala Leu Asp Pro Asn Asn Val Met Gly 
    210                 215                 220                 


Val Asp Leu Gly Ile Val Tyr Pro Val Tyr Ile Ala Phe Asn Asn Ser 
225                 230                 235                 240 


Leu His Arg Tyr His Ile Lys Gly Gly Glu Ile Glu Arg Phe Arg Arg 
                245                 250                 255     


Gln Val Glu Lys Arg Lys Arg Glu Leu Leu Asn Gln Gly Lys Tyr Cys 
            260                 265                 270         


Gly Asp Gly Arg Lys Gly His Gly Tyr Ala Thr Arg Thr Lys Ser Ile 
        275                 280                 285             


Glu Ser Ile Ser Asp Lys Ile Ala Arg Phe Arg Asp Thr Cys Asn His 
    290                 295                 300                 


Lys Tyr Ser Arg Phe Ile Val Asp Met Ala Leu Lys His Asn Cys Gly 
305                 310                 315                 320 


Ile Ile Gln Met Glu Asp Leu Thr Gly Ile Ser Lys Glu Ser Thr Phe 
                325                 330                 335     


Leu Lys Asn Trp Thr Tyr Tyr Asp Leu Gln Gln Lys Ile Glu Tyr Lys 
            340                 345                 350         


Ala Arg Glu Ala Gly Ile Gln Val Ile Lys Ile Glu Pro Gln Tyr Thr 
        355                 360                 365             


Ser Gln Arg Cys Ser Lys Cys Gly Tyr Ile Asp Lys Glu Asn Arg Gln 
    370                 375                 380                 


Glu Gln Ala Thr Phe Lys Cys Ile Glu Cys Gly Phe Lys Thr Asn Ala 
385                 390                 395                 400 


Asp Tyr Asn Ala Ala Arg Asn Ile Ala Ile Pro Asn Ile Asp Lys Ile 
                405                 410                 415     


Ile Arg Lys Thr Leu Lys Met Gln 
            420                 


<210>  35
<211>  422
<212>  PRT
<213>  Acidibacillus sulfuroxidans

<400>  35

Met Ile Lys Val Tyr Arg Tyr Glu Ile Val Lys Pro Leu Asp Leu Asp 
1               5                   10                  15      


Trp Lys Glu Phe Gly Thr Ile Leu Arg Gln Leu Gln Gln Glu Thr Arg 
            20                  25                  30          


Phe Ala Leu Asn Lys Ala Thr Gln Leu Ala Trp Glu Trp Met Gly Phe 
        35                  40                  45              


Ser Ser Asp Tyr Lys Asp Asn His Gly Glu Tyr Pro Lys Ser Lys Asp 
    50                  55                  60                  


Ile Leu Gly Tyr Thr Asn Val His Gly Tyr Ala Tyr His Thr Ile Lys 
65                  70                  75                  80  


Thr Lys Ala Tyr Arg Leu Asn Ser Gly Asn Leu Ser Gln Thr Ile Lys 
                85                  90                  95      


Arg Ala Thr Asp Arg Phe Lys Ala Tyr Gln Lys Glu Ile Leu Arg Gly 
            100                 105                 110         


Asp Met Ser Ile Pro Ser Tyr Lys Arg Asp Ile Pro Leu Asp Leu Ile 
        115                 120                 125             


Lys Glu Asn Ile Ser Val Asn Arg Met Asn His Gly Asp Tyr Ile Ala 
    130                 135                 140                 


Ser Leu Ser Leu Leu Ser Asn Pro Ala Lys Gln Glu Met Asn Val Lys 
145                 150                 155                 160 


Arg Lys Ile Ser Val Ile Ile Ile Val Arg Gly Ala Gly Lys Thr Ile 
                165                 170                 175     


Met Asp Arg Ile Leu Ser Gly Glu Tyr Gln Val Ser Ala Ser Gln Ile 
            180                 185                 190         


Ile His Asp Asp Arg Lys Asn Lys Trp Tyr Leu Asn Ile Ser Tyr Asp 
        195                 200                 205             


Phe Glu Pro Gln Thr Arg Val Leu Asp Leu Asn Lys Ile Met Gly Ile 
    210                 215                 220                 


Asp Leu Gly Val Ala Val Ala Val Tyr Met Ala Phe Gln His Thr Pro 
225                 230                 235                 240 


Ala Arg Tyr Lys Leu Glu Gly Gly Glu Ile Glu Asn Phe Arg Arg Gln 
                245                 250                 255     


Val Glu Ser Arg Arg Ile Ser Met Leu Arg Gln Gly Lys Tyr Ala Gly 
            260                 265                 270         


Gly Ala Arg Gly Gly His Gly Arg Asp Lys Arg Ile Lys Pro Ile Glu 
        275                 280                 285             


Gln Leu Arg Asp Lys Ile Ala Asn Phe Arg Asp Thr Thr Asn His Arg 
    290                 295                 300                 


Tyr Ser Arg Tyr Ile Val Asp Met Ala Ile Lys Glu Gly Cys Gly Thr 
305                 310                 315                 320 


Ile Gln Met Glu Asp Leu Thr Asn Ile Arg Asp Ile Gly Ser Arg Phe 
                325                 330                 335     


Leu Gln Asn Trp Thr Tyr Tyr Asp Leu Gln Gln Lys Ile Ile Tyr Lys 
            340                 345                 350         


Ala Glu Glu Ala Gly Ile Lys Val Ile Lys Ile Asp Pro Gln Tyr Thr 
        355                 360                 365             


Ser Gln Arg Cys Ser Glu Cys Gly Asn Ile Asp Ser Gly Asn Arg Ile 
    370                 375                 380                 


Gly Gln Ala Ile Phe Lys Cys Arg Ala Cys Gly Tyr Glu Ala Asn Ala 
385                 390                 395                 400 


Asp Tyr Asn Ala Ala Arg Asn Ile Ala Ile Pro Asn Ile Asp Lys Ile 
                405                 410                 415     


Ile Ala Glu Ser Ile Lys 
            420         


<210>  36
<211>  440
<212>  PRT
<213>  Ruminococcus sp.

<400>  36

Met Val Lys Val Val Lys Ile His Leu Ile Ser Glu Gln Phe Asp Lys 
1               5                   10                  15      


Ala Gly Asn Arg Ile Asp Tyr Glu Glu Val Asn Lys Ile Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Thr Val Gln Leu Leu 
        35                  40                  45              


Trp Glu Trp Asn Asn Phe Ser Ser Asp Tyr Val Lys Ala Ser Gly Ile 
    50                  55                  60                  


Tyr Pro Lys Ala Lys Asp Ile Phe Gly Tyr Ser Ser Val His Gly Gln 
65                  70                  75                  80  


Ala Asn Lys Glu Leu Arg Thr Lys Leu Ala Leu Asn Ser Ser Asn Leu 
                85                  90                  95      


Ser Thr Thr Thr Met Asp Val Cys Lys Asn Phe Asn Thr Tyr Lys Lys 
            100                 105                 110         


Glu Val Trp Lys Gly Lys Arg Ser Val Pro Ser Tyr Lys Ser Asp Gln 
        115                 120                 125             


Pro Leu Asp Leu His Lys Asp Ser Ile Lys Leu Ile Tyr Glu Asn Asn 
    130                 135                 140                 


Glu Phe Tyr Val Arg Leu Ala Leu Leu Lys Lys Ala Glu Phe Ala Lys 
145                 150                 155                 160 


Tyr Gly Phe Lys Asp Gly Phe Arg Phe Lys Met Gln Val Lys Asp Asn 
                165                 170                 175     


Ser Thr Lys Thr Ile Leu Glu Arg Cys Phe Asp Glu Val Tyr Lys Ile 
            180                 185                 190         


Asn Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Lys Trp Lys Leu 
        195                 200                 205             


Asn Leu Ser Tyr Ser Phe Asp Asn Lys Asn Ile Ser Glu Leu Asp Lys 
    210                 215                 220                 


Glu Lys Ile Leu Gly Val Asp Val Gly Val Asn Cys Pro Leu Val Ala 
225                 230                 235                 240 


Ser Val Phe Gly Asp Arg Asp Arg Phe Ile Ile Lys Gly Gly Glu Ile 
                245                 250                 255     


Glu Lys Phe Arg Lys Ser Val Glu Ala Arg Arg Arg Ser Met Leu Glu 
            260                 265                 270         


Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Arg Lys Lys 
        275                 280                 285             


Arg Thr Glu Pro Ala Leu Asn Ile Gly Asp Lys Ile Ala Arg Phe Arg 
    290                 295                 300                 


Asp Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr Ala Val 
305                 310                 315                 320 


Lys Lys Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr Gly Ile Thr 
                325                 330                 335     


Ser Lys Ser Asp Arg Phe Leu Lys Asp Trp Thr Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Thr Lys Ile Glu Asn Lys Ala Lys Glu Val Gly Ile Asn Val Val Tyr 
        355                 360                 365             


Ile Ala Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly Tyr Ile 
    370                 375                 380                 


His Lys Asp Asn Arg Pro Asn Gln Ala Lys Phe Arg Cys Leu Glu Cys 
385                 390                 395                 400 


Asp Phe Glu Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Gly Ile 
                405                 410                 415     


Lys Asn Ile Asp Lys Ile Ile Glu Lys Asp Leu Gln Lys Gln Glu Ser 
            420                 425                 430         


Glu Val Gln Val Asn Glu Asn Lys 
        435                 440 


<210>  37
<211>  497
<212>  PRT
<213>  Syntrophomonas palmitatica

<400>  37

Met Gly Glu Ser Val Lys Ala Ile Lys Leu Lys Ile Leu Asp Met Phe 
1               5                   10                  15      


Leu Asp Pro Glu Cys Thr Lys Gln Asp Asp Asn Trp Arg Lys Asp Leu 
            20                  25                  30          


Ser Thr Met Ser Arg Phe Cys Ala Glu Ala Gly Asn Met Cys Leu Arg 
        35                  40                  45              


Asp Leu Tyr Asn Tyr Phe Ser Met Pro Lys Glu Asp Arg Ile Ser Ser 
    50                  55                  60                  


Lys Asp Leu Tyr Asn Ala Met Tyr His Lys Thr Lys Leu Leu His Pro 
65                  70                  75                  80  


Glu Leu Pro Gly Lys Val Ala Asn Gln Ile Val Asn His Ala Lys Asp 
                85                  90                  95      


Val Trp Lys Arg Asn Ala Lys Leu Ile Tyr Arg Asn Gln Ile Ser Met 
            100                 105                 110         


Pro Thr Tyr Lys Ile Thr Thr Ala Pro Ile Arg Leu Gln Asn Asn Ile 
        115                 120                 125             


Tyr Lys Leu Ile Lys Asn Lys Asn Lys Tyr Ile Ile Asp Val Gln Leu 
    130                 135                 140                 


Tyr Ser Lys Glu Tyr Ser Lys Asp Ser Gly Lys Gly Thr His Arg Tyr 
145                 150                 155                 160 


Phe Leu Val Ala Val Arg Asp Ser Ser Thr Arg Met Ile Phe Asp Arg 
                165                 170                 175     


Ile Met Ser Lys Asp His Ile Asp Ser Ser Lys Ser Tyr Thr Gln Gly 
            180                 185                 190         


Gln Leu Gln Ile Lys Lys Asp His Gln Gly Lys Trp Tyr Cys Ile Ile 
        195                 200                 205             


Pro Tyr Thr Phe Pro Thr His Glu Thr Val Leu Asp Pro Asp Lys Val 
    210                 215                 220                 


Met Gly Val Asp Leu Gly Val Ala Lys Ala Val Tyr Trp Ala Phe Asn 
225                 230                 235                 240 


Ser Ser Tyr Lys Arg Gly Cys Ile Asp Gly Gly Glu Ile Glu His Phe 
                245                 250                 255     


Arg Lys Met Ile Arg Ala Arg Arg Val Ser Ile Gln Asn Gln Ile Lys 
            260                 265                 270         


His Ser Gly Asp Ala Arg Lys Gly His Gly Arg Lys Arg Ala Leu Lys 
        275                 280                 285             


Pro Ile Glu Thr Leu Ser Glu Lys Glu Lys Asn Phe Arg Asp Thr Ile 
    290                 295                 300                 


Asn His Arg Tyr Ala Asn Arg Ile Val Glu Ala Ala Ile Lys Gln Gly 
305                 310                 315                 320 


Cys Gly Thr Ile Gln Ile Glu Asn Leu Glu Gly Ile Ala Asp Thr Thr 
                325                 330                 335     


Gly Ser Lys Phe Leu Lys Asn Trp Pro Tyr Tyr Asp Leu Gln Thr Lys 
            340                 345                 350         


Ile Val Asn Lys Ala Lys Glu His Gly Ile Thr Val Val Ala Ile Asn 
        355                 360                 365             


Pro Gln Tyr Thr Ser Gln Arg Cys Ser Met Cys Gly Tyr Ile Glu Lys 
    370                 375                 380                 


Thr Asn Arg Ser Ser Gln Ala Val Phe Glu Cys Lys Gln Cys Gly Tyr 
385                 390                 395                 400 


Gly Ser Arg Thr Ile Cys Ile Asn Cys Arg His Val Gln Val Ser Gly 
                405                 410                 415     


Asp Val Cys Glu Glu Cys Gly Gly Ile Val Lys Lys Glu Asn Val Asn 
            420                 425                 430         


Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser Thr Pro Tyr Ile Asp Gln 
        435                 440                 445             


Ile Ile Met Glu Lys Cys Leu Glu Leu Gly Ile Pro Tyr Arg Ser Ile 
    450                 455                 460                 


Thr Cys Lys Glu Cys Gly His Ile Gln Ala Ser Gly Asn Thr Cys Glu 
465                 470                 475                 480 


Val Cys Gly Ser Thr Asn Ile Leu Lys Pro Lys Lys Ile Arg Lys Ala 
                485                 490                 495     


Lys 
    


<210>  38
<211>  497
<212>  PRT
<213>  Clostridium novyi

<400>  38

Met Ile Thr Val Arg Lys Ile Lys Leu Thr Ile Met Gly Asp Lys Asp 
1               5                   10                  15      


Thr Arg Asn Ser Gln Tyr Lys Trp Ile Arg Asp Glu Gln Tyr Asn Gln 
            20                  25                  30          


Tyr Arg Ala Leu Asn Met Gly Met Thr Tyr Leu Ala Val Asn Asp Ile 
        35                  40                  45              


Leu Tyr Met Asn Glu Ser Gly Leu Glu Ile Arg Thr Ile Lys Asp Leu 
    50                  55                  60                  


Lys Asp Cys Glu Lys Asp Ile Asp Lys Asn Lys Lys Glu Ile Glu Lys 
65                  70                  75                  80  


Leu Thr Ala Arg Leu Glu Lys Glu Gln Asn Lys Lys Asn Ser Ser Ser 
                85                  90                  95      


Glu Lys Leu Asp Glu Ile Lys Tyr Lys Ile Ser Leu Val Glu Asn Lys 
            100                 105                 110         


Ile Glu Asp Tyr Lys Leu Lys Ile Val Glu Leu Asn Lys Ile Leu Glu 
        115                 120                 125             


Glu Thr Gln Lys Glu Arg Met Asp Ile Gln Lys Glu Phe Lys Glu Lys 
    130                 135                 140                 


Tyr Val Asp Asp Leu Tyr Gln Val Leu Asp Lys Ile Pro Phe Lys His 
145                 150                 155                 160 


Leu Asp Asn Lys Ser Leu Val Thr Gln Arg Ile Lys Ala Asp Ile Lys 
                165                 170                 175     


Ser Asp Lys Ser Asn Gly Leu Leu Lys Gly Glu Arg Ser Ile Arg Asn 
            180                 185                 190         


Tyr Lys Arg Asn Phe Pro Leu Met Thr Arg Gly Arg Asp Leu Lys Phe 
        195                 200                 205             


Lys Tyr Asp Asp Asn Asp Asp Ile Glu Ile Lys Trp Met Glu Gly Ile 
    210                 215                 220                 


Lys Phe Lys Val Ile Leu Gly Asn Arg Ile Lys Asn Ser Leu Glu Leu 
225                 230                 235                 240 


Arg His Thr Leu His Lys Val Ile Glu Gly Lys Tyr Lys Ile Cys Asp 
                245                 250                 255     


Ser Ser Leu Gln Phe Asp Lys Asn Asn Asn Leu Ile Leu Asn Leu Thr 
            260                 265                 270         


Leu Asp Ile Pro Ile Asp Ile Val Asn Lys Lys Val Ser Gly Arg Val 
        275                 280                 285             


Val Gly Val Asp Leu Gly Leu Lys Ile Pro Ala Tyr Cys Ala Leu Asn 
    290                 295                 300                 


Asp Val Glu Tyr Ile Lys Lys Ser Ile Gly Arg Ile Asp Asp Phe Leu 
305                 310                 315                 320 


Lys Val Arg Thr Gln Met Gln Ser Arg Arg Arg Arg Leu Gln Ile Ala 
                325                 330                 335     


Ile Gln Ser Ala Lys Gly Gly Lys Gly Arg Val Asn Lys Leu Gln Ala 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Lys Glu Lys Asn Phe Ala Lys Thr Tyr Asn 
        355                 360                 365             


His Phe Leu Ser Ser Asn Ile Val Lys Phe Ala Val Ser Asn Gln Ala 
    370                 375                 380                 


Glu Gln Ile Asn Met Glu Leu Leu Ser Leu Lys Glu Thr Gln Asn Lys 
385                 390                 395                 400 


Ser Ile Leu Arg Asn Trp Ser Tyr Tyr Gln Leu Gln Thr Met Ile Glu 
                405                 410                 415     


Tyr Lys Ala Gln Arg Glu Gly Ile Lys Val Lys Tyr Ile Asp Pro Tyr 
            420                 425                 430         


His Thr Ser Gln Thr Cys Ser Lys Cys Gly Asn Tyr Glu Glu Gly Gln 
        435                 440                 445             


Arg Glu Ser Gln Ala Asp Phe Ile Cys Lys Lys Cys Gly Tyr Lys Val 
    450                 455                 460                 


Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Met Ser Asn Lys Tyr 
465                 470                 475                 480 


Ile Thr Lys Lys Glu Glu Ser Lys Tyr Tyr Lys Ile Lys Glu Ser Met 
                485                 490                 495     


Val 
    


<210>  39
<211>  2815
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  39
tgccaacatc tggtctgcgc acgatttttt ctatttgttt tttcactttt tccttcaaca       60

gcttgtccct tattttcttg actttcttct tgaaaaaaag gtcgtatttg attgttacca      120

ttttttgagt tcttccagga attcctcgcc gctgattccg ttgacgccgc ctttttcaca      180

tcttttaagc gcttcctcgg cgcgctcggc aaaacgcagg tctttctcca ggttctcgtc      240

gaaagcggtc gcgctcttca acacgaattt gtttccgctt cggattacca cgagcttgtc      300

tccctccttg aagccggcgc gcatttcgct gggaatcacg atttgccctt ttgaactcat      360

tcggctgaca ccaatgtcta tcataaggta agatgtgtct tacttactat atatttcttg      420

tgttttgggg tggcggcacg ctaattaatt taaaaggcgt attgctttgc aggagttgct      480

aaggagggtt gcctgtggaa atgatttcac tcaaacttaa actgcttcca gacgaagaac      540

aaaagaaatt gcttgacgaa atgttttgga agtgggcctc gatttgtacc cgcgttggtt      600

ttgggcgggc tgataaagaa gatttaaaac cgccaaaaga cgcggaaggg gtttggttta      660

gtttaacaca attaaatcaa gccaacacag acattaacga cttaagggag gcgatgaagc      720

accaaaaaca ccgcctagaa tacgaaaaaa accgtttgga agcgcaaaga gatgatactc      780

aggatgcctt gaaaaatccg gacagacgag aaataagcac taaaagaaag gatttattcc      840

gtcccaaagc gtccgtcgaa aaaggctttc tgaaactgaa gtatcatcaa gagcgttatt      900

gggttcgaag gctgaaagaa ataaacaaac taattgaaag gaaaacgaag acacttataa      960

aaatagaaaa ggggcgaatc aaattcaagg caacgcgaat aaccctgcac caaggctctt     1020

ttaaaattag attcggcgat aaacccgctt ttctgataaa ggcgttgtct ggaaaaaacc     1080

aaatagacgc tccttttgtt gtagtgccag aacaaccaat ctgcgggagc gttgtaaata     1140

gcaagaaata cttagatgaa attactacta atttcttggc ttacagcgta aatgcaatgc     1200

ttttcggttt gagccgcagc gaggaaatgt tgttgaaagc caaaaggcca gaaaaaatca     1260

agaaaaaaga agaaaaactt gctaaaaaac aatcagcctt tgaaaacaaa aagaaggaat     1320

tgcaaaaatt acttggtaga gaactaaccc agcaggaaga agcgattatt gaagaaaccc     1380

gcaaccaatt ctttcaagat tttgaggtga aaataaccaa acaatactcg gaattactca     1440

gcaaaattgc taacgaactc aagcaaaaaa atgattttct gaaagtaaac aaatatccta     1500

tacttttaag gaaacctctc aagaaagcca aatcgaaaaa aattaataat ctttcgccaa     1560

gcgaatggaa atattacctc caattcggag ttaaaccttt actaaaacaa aaatcaagac     1620

gaaaatcaag gaatgttttg ggaatagacc gcggccttaa acacttgcta gccgtaaccg     1680

ttcttgaacc cgacaaaaaa acgtttgtat ggaacaaact ttacccaaac ccaattacgg     1740

gctggaagtg gaggcgacgc aagcttttgc gctccttaaa gcgattgaag aggcgcatta     1800

aatcgcaaaa acacgaaaca attcatgaaa accaaacgag gaaaaagctc aagagtttac     1860

aaggcaggat agatgacctg cttcataata tttccagaaa aatagtggag accgcaaaag     1920

aatatgatgc ggtaatagta gtggaagacc tccaaagcat gcggcaacac ggtcgttcaa     1980

aaggcaatcg tttgaaaaca ctgaattacg cgctaagcct tttcgattac gcaaacgtga     2040

tgcaacttat aaagtacaag gcgggtatag aaggaatcca aatatatgac gttaaaccag     2100

ctggcacaag ccaaaattgc gcgtattgcc ttttagcgca aagggattca cacgaataca     2160

aaagaagcca agaaaactcc aaaataggtg tttgcttaaa tcctaactgc caaaaccaca     2220

agaaacaaat tgacgctgac ctaaacgcgg caagagtaat agctagttgt tacgccttaa     2280

aaattaatga ttcccaacca tttggaacaa ggaaaagatt taaaaaaaga acaacgaatt     2340

aatttaacgg taacctgtgg aattcagttt actttggcag tcctaaaaga accgtgtata     2400

ccaacggata tggaatcggt gtaaatcgaa ccatcctttg ggacgggtgc tcttctatat     2460

ggcgagcacc ttaagaagac tcgttgcaag tcttttgggc tcataaacca ttgtcgcgat     2520

ggataacggc ctgacttagt ttcggttcaa aattggttgg tctttttaaa taaggctaca     2580

aaaaggccct tatccgatta cgctttttat ccgggcattt tcctgccttt ttaggcgaat     2640

tccaacgatt ttttcggctg ttgcacagtg ctaattagag aaactaggaa tgcaacaaca     2700

atgattatcc gtataattcg ttgactttgc gggttgcaca gtgctaatta gagaaactag     2760

gaatgcaacc tgcccattcc gtcgcactct taaccattat ttcagggttg cacag          2815


<210>  40
<211>  3687
<212>  DNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  40
gtcgagcagg cgcgcaacgt cacccggttt ctccttgaca gaaagcagga ataccgggga       60

ttcacgagca ggtggtgagc atgatctact gggtgattta cgacatcagc gcaaacgggg      120

cgcgcagcag ggtggcttcc gcgtgcaaga actacggatt caagcgcatc cagaagagcg      180

cgtttctggg caacatcacc aaaaacaagg cggacatgct cgccatccag tgcagggaca      240

tggtgaagga ggaaggcgac tgcgtcttca tcatcccggc gtgcgaacag tgcttcaggg      300

gaaaggaggt actcggcacg cttgacgaga cggctgcgcg gaagctcgac tacctgatag      360

tgggggaaga tggacgacag acagcatctc acggcggctg acctgctgaa ctactgctac      420

tgcccgcgca ttgtctatta cgtgcacgtg ctgaagctgg cgcaggccac gaccgcgaag      480

gagctgaaag ggagggagaa gtacgatgat ttcaagcgaa aatcaagaag gaacaagatt      540

gtacgacgtg accattgaat caaagaggca cggcctcatc accaaggcgg actgcatcat      600

gtttgacagg gagaagggcg aggcataccc cattcagcat aagtacagct tcaggccgaa      660

ggcgatatat cgcacctaca tcattcaatt gcttatggag gccctccttg tcgaggagca      720

gttcaatgtt ttggtccctc atggcttcat catcttcgag cgctccaagg agacagtaaa      780

ggttgatttg tcaaataagc agaaagtttt atatgccgtg gggcagataa gaggaattat      840

tgggggagaa aagttcccgc cgccgacgga atggaaaaag cggtgcgtgg actgttacta      900

taacaagctg tgttgggggt aagatggaag tacaaaaaac tgtgatgaag acactttctt      960

tgagaatatt aagacctctg tactcacaag aaatagaaaa agagattaaa gaagaaaaag     1020

aaagaagaaa acaagccgga ggaactggag agcttgacgg gggattttat aaaaagcttg     1080

agaagaagca ttcagagatg ttcagctttg ataggttaaa cttattgttg aatcaattac     1140

aaagagaaat tgctaaggtc tacaatcatg ccatcagtga attgtatata gcgactatcg     1200

ctcaaggtaa caagagcaac aaacattata ttagtagtat tgtctataat cgagcatatg     1260

gatactttta taacgcttac atagccttag ggatatgttc aaaagttgaa gcaaatttta     1320

gatccaatga actcctaaca caacaaagcg cattgcctac agcaaagtca gataattttc     1380

caatagtttt acataaacaa aaaggtgctg agggagagga tggaggattt aggatatcta     1440

ctgaggggag cgatctgata tttgagatac ccattccgtt ctatgaatat aatggggaga     1500

accgaaaaga accctataaa tgggttaaaa aaggaggaca aaaacctgtg ttaaaactta     1560

tactttctac ttttaggaga caaagaaata aggggtgggc aaaagacgag ggcacggatg     1620

cggaaataag aaaggttaca gaagggaagt atcaagtcag ccaaatagaa ataaataggg     1680

gtaaaaaact aggagaacat caaaaatggt ttgccaattt cagcatagag caaccaattt     1740

atgaaagaaa acctaatcgg agtattgtcg gcggattaga cgtgggaata agatcccccc     1800

tagtatgtgc aattaacaac tcattttcga gatattctgt tgattccaat gatgtattta     1860

agttttctaa acaagtattc gcatttagaa gacggctatt atcgaaaaac tctttgaaaa     1920

ggaaaggtca tggggcggct cataagttag aacctatcac ggaaatgaca gaaaaaaatg     1980

acaagtttag aaagaaaata attgagagat gggccaagga agttacaaat ttctttgtta     2040

aaaaccaagt aggaattgtt cagatagaag atttatcaac gatgaaagac agagaggatc     2100

atttttttaa tcaatatctt agaggatttt ggccttatta ccaaatgcag acattaattg     2160

agaacaagct caaagagtat gggattgagg taaaaagggt acaggcaaaa tatacgtctc     2220

agttgtgctc aaaccctaat tgcaggtatt ggaataacta ttttaacttt gaataccgaa     2280

aagtaaataa attcccaaaa tttaaatgtg aaaagtgtaa cttagaaata agtgctgact     2340

ataacgctgc tcgcaatcta tcaactcccg atatagagaa atttgtggca aaagctacaa     2400

aaggcattaa tttgccagaa aaatgagaat gttattccat aataacattt gatgcacacg     2460

attcctccct acagtagtta ggtatagccg aaaggtagag actaaatctg tagttggagt     2520

gggccgcttg catcggccta aagttgagaa gtgtcagact ctgataaccc tcaacgacga     2580

tattctttat ttcggttcaa agttctgcac aaaacaggtg agtccttata aaccggtgtg     2640

cagaacgccg gctcaccttt ttccttcatc cgattttacg cttaaaagcc gtaaaaacgc     2700

ggaattcggc gccgttgcag aacccgaata gacgaatgaa ggaatgcaac aaaataatac     2760

aagcgtgtct ttgttaaaac aatccacagt tgcagaaccc gaatagacga atgaaggaat     2820

gcaacctcga tttacacgac atctcgtctg agtatgacgg ttgcagaacc cgaatagacg     2880

aatgaaggaa tgcaacctgt gtaagtgcgt tagacatcga taacgtctgt aatgttgcag     2940

aacccgaata gacgaatgaa ggaatgcaac tttatctttt acatgaatcg cgtaatctta     3000

acctggttgc agaacccgaa tagacgaatg aaggaatgca actgaagtcc ccctctgcac     3060

tcacgtaaaa attattgttg cagaacccga atagacgaat gaaggaatgc aactgtagca     3120

gtactgctcg ggtcgctcag ctaatgcgat gttgcagaac ccgaatagac gaatgaagga     3180

atgcaacagc ctcgaaaggt atataaacct agccgactat cgggcatcca tgaagcaaga     3240

catgatttcc atatcgcgga aagagtacga gggcatgaag gaaaccatag agatgctgca     3300

aagcccggag atgatgaggc agattctgga gagcgagaag aacatctcag aaggcaaaat     3360

aaaaaaattt gatgtctaat atacgttatg ggttccgacg gcctctacaa caattcttcg     3420

gtttgaatcg tcaatgctgt acaccattct tatgcttgag ccgagccagc agctccattt     3480

gcccgccaat ctcccatgca gaggatgagc gccaatttca gtcctcggcg actgctttag     3540

tttatgaagc ttgccgacaa tgtcctgcct gccttttaca taacgtgcaa gcaatttttc     3600

cgccttgctg tttgccgtat agatttcata cataggtgga ttgaatgatg aaactcatat     3660

ataaacaatg ccctccaacg agaatag                                         3687


<210>  41
<211>  2929
<212>  DNA
<213>  Parageobacillus thermoglucosidasius

<400>  41
tcaagcaatt atcgtatagt ctctgtcgtt tggcagggct ttttttattt tcgtggaatg       60

aaatattagg aggtgatatc gtgtttgaga tcgtaggccg actgcgctgt cccatttgtt      120

cagaggtggt tcgaccagac gagaaggtct tccttgacat tatcaacacc atcatccatc      180

agaagtgcta ctatcaatcc ccacgtagac tcccgatcaa agacaaaggc ccattccaga      240

aaatgttcat gaaatatcca ttcttcaacg aggatgagga agatgattcc atatgaaaag      300

cccttctcat cgagaggggc ttgtttattt tattgcatag ttttttgcaa aatgaataaa      360

aaatcatgtg acaacttacg taaaccaaag acaaaaatgt tccacgttag taaaaagtat      420

taaatggaaa tttaatgtca aaaatggagg tggtattgtt tcaaaagtaa cacttgttgt      480

aaaaaagggg ttgttaattg atgaagtata cgaaagtaat gaggtatcaa attatcaaac      540

ccttaaacgc agaatgggat gaattgggaa tggttctccg tgacatccag aaagaaactc      600

gcgcggcatt aaacaagacg attcaattgt gttgggaata tcaaggattt agtgcggatt      660

ataagcagat acacggtcag tatcctaaac caaaagatgt tttaggatac acaagtatgc      720

acggatatgc ttatgatcgt ctcaaaaatg aattcagcaa aattgcaagt tcaaaccttt      780

cgcaaactat caaacgagcg gtagataaat ggaatagtga cttaaaagaa attctgcgtg      840

gtgaccgctc catccctaac ttcagaaaag attgtccaat tgatatcgtt aagcaatcga      900

cgaaaataca aaaatgtaat gatggatacg tattaagcct cggtttaatt aatagagagt      960

ataaaaatga attgggacgg aaaaacggag tatttgatgt acttataaaa gcaaacgata     1020

aaacccagca aaccatatta gaacgaatta taaatggcga ttatacatat acggcatctc     1080

aaataatcaa tcataaaaat aagtggttta ttaaccttac ctatcaattt gaaactaaag     1140

aaacagcctt agatcccaat aatgtcatgg gagttgatct aggaattgtt tatcctgttt     1200

atatagcatt taataacagt cttcaccgtt atcatattaa aggaggagaa atagaacgat     1260

tcagacggca agtagaaaaa aggaagaggg aattgttaaa tcaaggcaaa tattgtggag     1320

acgggcgtaa agggcatggt tatgctacaa gaacaaagtc cattgaatca attagcgata     1380

aaattgcgag atttcgtgac acttgcaatc ataaatattc caggtttatt gtagatatgg     1440

cgcttaaaca taattgtggg ataattcaaa tggaagattt gactggaatt agcaaggaaa     1500

gtacattttt gaaaaattgg acatattacg atcttcagca gaaaatcgaa tataaggcac     1560

gagaagcagg aatacaagtt ataaaaattg aaccccaata tacatctcaa cgttgtagta     1620

aatgtggcta tattgataaa gagaatcggc aagaacaagc tacatttaag tgcatcgaat     1680

gtggttttaa gacaaatgct gactataatg cagcaaggaa tatcgcaata ccgaacattg     1740

acaagataat aaggaaaacg ttaaaaatgc aataaaaaat cccttggggc gattcagcgt     1800

ccttaagtcg agaagtgccg taataagcat ctaaaaatgc ctaacggtaa cactcgataa     1860

ggtagtcctg ctaggcaggc tgaaacccta gccacaaaat ccggctaggc atcatacaga     1920

aaattgttgt cgaactataa tcgtgcaaaa atcccaaggg atcgacgaca tttaaaatgt     1980

tgatagctaa gggatttacg gttatttcta aaaaagaaaa tctcttgaga gagataagtg     2040

aaatgttgct ttatcaatat cttttggggt ttctgaagaa actatgtatg atgtgaagta     2100

ttcgcgatca accaacgcga tcgtgtcggc aatttgagtt tctgaagaaa ctatgtatga     2160

tgtgaaggta aaaattggcg aggacgaatt agatgacaca gagtttctga agaaactatg     2220

tatgatgtga agcatttgaa agagctatgc aaatacttcg atcaaaaggt ttctgaagaa     2280

actatgtatg atgtgaagtc gctcattcct ctccctctct ttcttcatga agtaggtttc     2340

gaagaaacta tgtatgatgt gaagttatcg tattgacaca gtttgttccc cacttggccg     2400

tttctgaaga aactatgtat gatgtgaagt ttgttcgatg gaaagtacga agatgggaaa     2460

gtagtttcaa aaagcccttc tcgtatgaga aggggggatt gaaggatatt gtatgccgac     2520

aatcttgccg acattctgcc gaccaaattt tttgttcatg taatttttta tggttcataa     2580

tgactttaga atgttgtaaa atcgaccatt ttgaaatgaa ctaattcccg atttcaccta     2640

ctcccccacc ttgacagggt ggaggtcgct ggttcgagcc cagtcggaat cactaaaatg     2700

tgaggcttga aatccttgcg tatcaagggt ttcaagcttt ttgtttttta tagcaggcac     2760

tcaaaatagc gtccaaatta cggttggtgc cattttggtg ccgaagcatt tttagtttga     2820

ttttgataac aggacatcga tttgattagc cgcttcctct tgcatattag gtaatacatg     2880

agaataaatg tctagtgttg ttttaatatt actgtggcct agacgttcg                 2929


<210>  42
<211>  3530
<212>  DNA
<213>  Acidibacillus sulfuroxidans

<400>  42
acctgcataa ggttgagaac ctttcttatg cgaaaatcgc agaacttttg ggcgtaaaaa       60

aagggagcat tgagcgatat atagagatgg cccgtaagaa actggagcgg ccatcagcgc      120

aactcgaaat ggaaaacctt tcttacgaaa agattgtgca agatttgggc gaaaagagaa      180

atgtaccgcg agcaatagat actacgagtg agaaggaata ctcttcggtg caacttgagt      240

ttgattttga atgattactg gttcatattt atattttctc ggctccttta tctttgggag      300

ccgtatgtta tttttgagtg ttaatattta gattgaatac tttttgttgt aaaaagaact      360

ggtgtctgat acgataaaag aaacttgtga aataaactag tgcatatcat ggctcgaaaa      420

cttgaaattg tgttaattct atggtgtaaa ttctaattag catcacaatg tagtgttttg      480

tttagacgga ggcgagtgga atgatcaaag tatatcggta tgagatcgta aaaccgcttg      540

atttagattg gaaagagttt ggaactattt tacgacagtt acaacaggaa actcgttttg      600

ccttaaacaa agcgactcaa ctggcttggg aatggatggg ctttagtagt gattataagg      660

ataatcatgg ggaatatcca aaaagtaaag acattctcgg atacacgaat gttcacggat      720

acgcttacca tacgatcaaa accaaagcat atcgcttaaa cagtggtaat ttatctcaaa      780

ccatcaaacg tgcgacggat cgttttaaag catatcaaaa ggaaatctta cgtggcgata      840

tgtccattcc gtcctataaa cgagatattc cactcgatct gattaaagag aatatcagcg      900

taaatcgtat gaatcacggg gattatatcg cttcgttatc tctgttaagc aatccagcca      960

agcaagaaat gaatgtaaag aggaaaattt cggtcataat cattgtccgt ggcgcaggga     1020

aaacaatcat ggacagaatc ctaagtggtg aataccaagt ctctgcttca caaataattc     1080

acgatgatcg aaaaaacaaa tggtatttaa acataagtta tgattttgaa ccccaaaccc     1140

gagtgttgga tctaaataaa ataatgggga ttgatttagg cgttgctgtt gccgtttaca     1200

tggcatttca acatacccct gctcgataca aattggaggg aggtgagatt gaaaattttc     1260

gtagacaggt agaatctcga cggattagta tgttacgtca aggtaaatat gccggtggtg     1320

cccgtggagg gcatgggcga gataaaagaa taaaaccgat tgaacagctt cgagataaaa     1380

ttgctaattt tagagatacc acaaaccatc gttatagtag atatatagtg gatatggcaa     1440

ttaaagaagg ttgtggaacg attcagatgg aggatttaac gaatatacgc gatattggat     1500

ctcgattttt acaaaattgg acctattatg atttgcagca aaaaattatt tataaagccg     1560

aagaggcagg aattaaagtc ataaagatcg atccccaata taccagtcaa cgttgtagtg     1620

aatgtggtaa tatagattcc gggaatcgaa ttggacaagc tatctttaaa tgcagagctt     1680

gcggatacga agccaatgca gactacaatg ctgcacgaaa catagcaata ccgaacattg     1740

acaaaattat agctgagagt atcaaataaa aatctttccc aaatacttct attcgtcggt     1800

tcagcgacga taagccgaga agtgccaata aaactgttaa gtggtttggt aacgctcggt     1860

aaggtagcca aaaggctgaa actccgtgca caaagaccgc acggacgctt cacatatagc     1920

tcataaacaa atgtcgtcga cctctaatag cgtaaaaacc tccggggatc gacgacagca     1980

aaatgcaata tagtcgggct tttcaaaaaa acgccggtat aaaccgacga agcgcgaacg     2040

ctgatttttt gcggaagaaa cgggtttgcg agctagcttg tggagtgtga accgagatgc     2100

tgtagttgat gattatcttc aagatgctag gcgtttgcga gctagcttgt ggagtgtgaa     2160

ccagggtcgg aacgaatcgg gtacggtagc gggctatccg tttgcgagct agcttgtgga     2220

gtgtgaactc cgcctgcctg tcttactacc tccacagggt tgccgtgttt gcgagctagc     2280

ttgtggagtg tgaactatac ttatactagg ataccctaaa atcgagcaga agtttgcgag     2340

ctagcttgtg gagtgtgaac cttcgataaa ccgtatattg gacttttttg gagtttcgtt     2400

tgcgagctag cttgtggagt gtgaactgat gattgtgaag gagattttga agatcgaacc     2460

agtttgcgag ctagcttgtg gagtgtgaac accaatcgct caatctcgtc atcacaatta     2520

gcaaaaagtt tgcgagctag cttgtggagt gtgaactaca gtagaagcaa cacaattcca     2580

acccaattcc atagtttgcg agctagcttg tggagtgtga accaggtacg aatatgtaga     2640

acgaaaaggt ggaatggatg tttgcgagct agcttgtgga gtgtgaacaa ttcgttaatc     2700

gtctatctca aaaactagta aataagtttg cgagctagct tgtggagtgt gaactgtcaa     2760

cgtccccaat atacatttct ggcctttttc tagtttgcga gctagcttgt ggagtgtgaa     2820

cataagctaa ggtataaatc gcaaacggaa tggacagggt ttgcgagcta gcttgtggag     2880

tgtgaactct tccactggct attcttctat ttcttctgct gaggtttgcg agctagcttg     2940

tggagtgtga actgtatcaa tatctttccc aaaaagctac ggtcgatcgt ttgcgagcta     3000

gcttgtggag tgtgaaccct cttcctctct ctgctgccgc actttagcct gcggtttgcg     3060

agctagcttg tggagtgtga actcttccac tggctattca tctatctctt ctgttgaggt     3120

ttgcgagcta gcttgtggag tgtgaactgt atcaatatct ttcccaaaaa gctacggtcg     3180

atcgtttgcg agctagcttg tggagtgtga actggaaatg gtagtgatgg ggcgttcgcg     3240

cctgcgccga gtttgcgagc tagcttgtgg agtgtgaact taccctatgc acatctggta     3300

ttaagtcaat agatcaccat gccgcctgag cggcaccagt agaaggatga aaatgggctt     3360

gtgtcgaaat gacaccttag cggctggcga aggtaggtcg ttccaaactg gtgccatgag     3420

cccgctcaat agactgacta cgacgaccca gtgcaccata gtatgttgct ccctttaggg     3480

aagcacgcag gatagaatga tctttatggt cgttgcacca gcccttcaat                3530


<210>  43
<211>  2702
<212>  DNA
<213>  Ruminococcus sp.

<400>  43
ttgtcacaaa gatcacgaag caattaccat tctgacctag ctgccgtgcg acttcaaaac       60

cggtcatttc aggcatatca aggtcaagaa atatagccga aaaaggcttt ttaccatggc      120

agtaaaaaaa gctctcagct ttggtaaacg tttctatttc agccttgacc gaccttgatt      180

caagttcatt tgccagcata gatttaaaaa actgaagaaa aacagcatta tcatcacaaa      240

ctgcgatccg cattttttca cgtcctttta taacatagtc tgtgtacgat tttatattac      300

cataattata ccgtaaggtc aagccataaa accagcaata agcacctagc gtcaagaatt      360

gtcatgttgt gccaaaatcg aggaactttg ttccaaaaac cacacctcat atttgtccct      420

tttgccaatt tacaaaaata tacttatgtg ttacaataat agagtaaagt atattgatcg      480

tgtgaaatgg ggtgacatta ctggtcaaag tcgtaaaaat ccatctaatt agtgagcaat      540

ttgacaaagc aggcaaccgg atagattatg aagaagtcaa taaaatactg tgggaattgc      600

aaaagcagac acgagaagca aagaataaaa ctgttcagct tctttgggaa tggaacaatt      660

tttcaagcga ttatgttaag gcgagtggca tatatcctaa agcaaaagac atatttggct      720

actcaagtgt gcatggacaa gcaaacaaag aattaagaac aaaactcgct ttaaattcaa      780

gtaatctttc cactaccaca atggacgtat gtaaaaattt taatacatat aaaaaagagg      840

tatggaaagg caaacgatca gttccttcgt acaaatcaga ccaacctctt gatctgcaca      900

aagactctat aaagctgata tatgaaaaca acgaatttta tgttaggctc gctttattaa      960

aaaaagctga atttgcaaag tatggtttta aagacggttt tcgttttaaa atgcaggtga     1020

aagataattc taccaaaact attcttgaac gctgttttga cgaagtatac aaaataaatg     1080

ccagcaaact tttatatgac caaaagaaaa agaagtggaa gcttaatctg tcttatagtt     1140

tcgacaataa aaacatttct gaacttgaca aagaaaagat ccttggtgtt gatgtaggcg     1200

ttaactgtcc tttagtcgct tcggttttcg gcgatcgtga ccgattcata atcaagggcg     1260

gcgaaattga aaaattcaga aaaagcgtgg aagctcgcag acgttcaatg ctcgagcaaa     1320

caaaatactg cggtgacgga agaattggtc acggcagaaa aaaacgcact gagcctgccc     1380

taaatatagg cgacaagata gcaagatttc gtgatacaac aaaccacaaa tacagcagag     1440

ctttgataga atatgctgta aaaaagggct gcggaactat ccaaatggaa aagctgacgg     1500

gtattacatc taaatctgat cgttttctaa aagactggac ttattatgac ctccagacaa     1560

agatagaaaa caaggcgaaa gaagtaggga taaatgtcgt ctatatcgcc cctaaatata     1620

caagtcagag atgtagcaaa tgcggatata tccacaagga taacagacca aatcaggcga     1680

aatttagatg tcttgaatgc gattttgaaa gtaatgcaga ttataatgca agtcagaata     1740

tcggaattaa aaacattgat aagataatag aaaaagattt gcaaaagcaa gaaagcgaag     1800

tccaagtgaa cgaaaacaag tagaaggttc acacaatttc agggcgactc ggcgtcctaa     1860

aatcgagaaa gtgtacataa gtttttaaca aaatacggta aatactctcg gtaaggtttt     1920

aacgtgcaca taataatccg tgcaacaggg ttacactttt gtgcaatttt gcagttgcaa     1980

cttacgcata ggtgtaaaat acgaggtgaa tgttactgtt gttgtgtttt cctcaaaagt     2040

tgcaacttac gcataggtgt aaaatacgag atcagaagtc aggataatgt tatccttgtc     2100

cgtgttgcaa cttacgcata ggtgtaaaat acgaggtcca gaaaatcgtc tgacattatc     2160

gtttgttcgt tgcaacttac gcataggtgt aaaatacgaa gcactcaatt tgcattgtga     2220

tacgatattg aattacaatc acatatttgt aaaacaacaa aagggctgtc cacacagccc     2280

ttttgttctt atctaaccta tgccaagccc cctacccctt aggctttttc atagtaagcg     2340

aaatacgctt tttcttcagg tcaacgttaa gtacccaaac cttaactacc tccccgacct     2400

ttacgacctc aagagggtgc tttatatatc tgtcgcacat ctgagaaata tgtacaagtc     2460

cgtcctcgtg aacaccgata tcaacgaacg ctccgaagtc tataacgttt ctcactgtgc     2520

ccataagctc catgcccggc ttcaagtctt taagctccat aatgtcgccg cttctcataa     2580

gcggtggagg cagctcgtca cgagggtcac gaccaggctt ttcaagctcc cctactatgt     2640

cctttaacgt cggtgcacca atgccaatat ctgtggcaag cttcttcatg cccattgcat     2700

tg                                                                    2702


<210>  44
<211>  5157
<212>  DNA
<213>  Syntrophomonas palmitatica

<400>  44
gcaattgcta taccaaaaaa tactgcaacc ggaaaataaa atttatccag gatgcagccc       60

tggataaaaa ggaatatagt tttatttctc tgtttttatc cttcttttgt agaaggattt      120

ttctgtcttt aatattatcg tttagttcat ctgttgttat cagcataagt tcccaaagaa      180

cgtgcgcata atcatcagta gtggtactaa ctgacctgcc ccacaaattc ttgaataatt      240

ttttgattta cgtccaattc cagtagccgc ataacaaaag tgtgcctcaa gccatgtaaa      300

ttaaattctt tgatacctgc cttatcctta acccgataaa aaactcggtt aaaattacgt      360

ggctcgtaca gctaagatgc aactaataaa tccctatacc taaccggagt ctggtggcag      420

atcagttata agtcaaaccc cttttttgac acaatatgtt tgttagtata taatttgaca      480

ttgagagggg tattctgttg atgggcgaat cggtaaaagc aataaaatta aagatactgg      540

atatgttttt agaccccgaa tgcacaaagc aggatgataa ctggcgcaaa gatttgtcta      600

ctatgtccag attctgcgct gaagcgggga atatgtgtct gcgcgacctg tataattact      660

tttcaatgcc caaggaagac cgtatttcct caaaagactt atataacgct atgtatcata      720

aaactaaact tctccatcct gaattaccag gtaaggtagc gaaccaaata gtaaaccacg      780

ctaaagatgt ttggaaacgc aacgctaaac tcatttatcg gaaccaaatc tcaatgccta      840

catataagat aacaacagca ccaatccggc tgcaaaataa catttataaa ttaataaaaa      900

ataagaacaa atacataata gacgtacagt tatactccaa ggaatactcc aaggatagtg      960

gtaaaggcac tcataggtat tttctggtag cagttagaga ctcatcaacc cgtatgatat     1020

tcgaccgtat tatgagtaag gaccatattg acagtagtaa atcatacacg caaggacaac     1080

tccaaatcaa gaaagaccac caggggaaat ggtattgcat cataccctat acattcccta     1140

cacatgagac agtcctcgac cctgataaag tcatgggagt agaccttggc gttgcaaaag     1200

ctgtttactg ggcgtttaat agttcttata aaagaggctg tatcgacggt ggggaaatag     1260

aacatttccg caaaatgata cgagctcgca gggtgtccat ccaaaatcaa atcaaacatt     1320

caggggacgc ccgtaaagga catgggcgca aaagggcgtt aaaacccata gaaacattga     1380

gcgagaagga aaagaatttt agggatacaa taaaccaccg ctatgcaaat cgaattgtag     1440

aagctgctat taagcaaggc tgtgggacaa tccaaatcga aaaccttgaa ggtatagctg     1500

acacaacagg cagtaaattt ctcaagaact ggccttatta cgacctgcag acaaaaattg     1560

ttaataaagc caaggaacat ggcattaccg ttgttgcaat aaacccccaa tatacatccc     1620

aaaggtgttc gatgtgcggg tatattgaaa aaaccaaccg ttcatcacag gcagtatttg     1680

aatgtaaaca atgcggttac ggcagtagga ctatatgtat taactgcagg cacgtccaag     1740

tatccgggga tgtttgtgag gaatgtggcg gcatagtaaa aaaagaaaac gtaaacgcag     1800

actacaatgc ggcaaaaaac atatccacac cgtacatcga ccagataata atggagaagt     1860

gtttagaact aggtattcct taccgcagta taacctgtaa agaatgtggt cacatacagg     1920

cttcaggaaa tacctgcgag gtttgcggaa gtactaatat tttgaaacca aagaaaatta     1980

gaaaagcaaa ataatcgcga accccaagtt ataaaaaagg tctttgacaa caaaacaagt     2040

catatcgctt taaagcctga cataatttac tctgtttcgc gcgccagggc agttaggtgc     2100

cctaaaagag cgaagtggcc gaaaggaaag gctaacgctt ctctaacgct acggcgacct     2160

tggcgaaatg ccatcaatac cacgcggccc gaaagggttc gcgcgaaact gagtaataaa     2220

acattgcgga tgcggcaata cagaaccgct gtcgcatctt gcgtaagcgc gtggattgaa     2280

actgtagtat ttgcgggttg agattggcgg gaattagtcg catcttgcgt aagcgcgtgg     2340

attgaaaccg gttcgcacag gcagttttag cattggtgtg gtgtcgcatc ttgcgtaagc     2400

gcgtggattg aaacaacaac ccgttcccac ggtgcaccac aatgagggtc gcatcttgcg     2460

taagcgcgtg gattgaaact taaatctatg tcaactgttg ccagtattgt caccgtcgca     2520

tcttgcgtaa gcgcgtggat tgaaaccaaa ctgaagatcg aatgttgcat cagctccagc     2580

gtgtcgcatc ttgcgtaagc gcgtggattg aaacacaaat ttcatttact tccatcccaa     2640

tttttacagt cgcatcttgc gtaagcgcgt ggattgaaac tttgtcgttt taacctgtat     2700

gtcgtatgca ttttgtcgca tcttgcgtaa gcgcgtggat tgaaactagt ctgttttcta     2760

ggtcattgat tttgtcaagc gtcgcatctt gcgtaagcgc gtggattgaa accgaaggag     2820

ggttaatcgt ttgattctta aagaacgtcg catcttgcgt aagcgcgtgg attgaaacat     2880

gtttgaaggt attgttcaac accctacaca aaagtcgcat cttgcgtaag cgcgtggatt     2940

gaaactgtcc agcaaggcaa gtgcagtaaa gaccgttagt cgcatcttgc gtaagcgcgt     3000

ggattgaaac aaaacgatat tcagacccaa cagcaaaccc tagcgtcgca tcttgcgtaa     3060

gcgcgtggat tgaaacttga tcggtaattg cgccatgcct tattttatcg gtcgcatctt     3120

gcgtaagcgc gtggattgaa acctcaaact taaaacccct acatgtcata tctttgtcgc     3180

atcttgcgta agcgcgtgga ttgaaacaac aaagtggaag gatttcccgg agcagatatt     3240

agtcgcatct tgcgtaagcg cgtggattga aacatgcttg ttgaacggtg caaacacacc     3300

ttcaatggtc gcatcttgcg taagcgcgtg gattgaaacc gcttatttgc ttgctgatga     3360

acaagttgca gacgtcgcat cttgcgtaag cgcgtggatt gaaacttgac cacatccaac     3420

aatggtcatt gcatcagggt cgcatcttgc gtaagcgcgt ggattgaaac atttatgccg     3480

gcaattatgg aatttatgat gtagtcgcat cttgcgtaag cgcgtggatt gaaactggta     3540

gtttattgat gtcaagttct gtccatctcg tcgcatcttg cgtaagcgcg tggattgaaa     3600

catacaccct accctaaaaa acaacacaca ataagcgtcg catcttgcgt aagcgcgtgg     3660

attgaaactt ctctgtcgaa atttttgttt atttactggt ttgtcgcatc ttgcgtaagc     3720

gcgtggattg aaacatattg ccttgctgac atataagcgt cataagccgt cgcatcttgc     3780

gtaagcgcgt ggattgaaac tgaagcctgg ggttatgggt tttcgtccgt catgtcgcat     3840

cttgcgtaag cgcgtggatt gaaaccaaga gcaacctcaa ccaaacaccg ccgatatttc     3900

gtcgcatctt gcgtaagcgc gtggattgaa acttttttat tgcccttttt aggttggcat     3960

tgtctacgtc gcatcttgcg taagcgcgtg gattgaaaca ttttaaatgg tttacttgtt     4020

aaggcaattc gttgtcgcat cttgcgtaag cgcgtggatt gaaactgatg cccccaatcc     4080

atattggggt ggaatattca gtcgcatctt gcgtaagcgc gtggattgaa acggtttgca     4140

agtatatgcc gtactgttgt tctaatgtcg catcttgcgt aagcgcgtgg attgaaactc     4200

aaaatttgaa gcgtggcttg atttactttt gcgtcgcatc ttgcgtaagc gcgtggattg     4260

aaactgtaat aatgggaata aaaagccgcc cacattgtcg catcttgcgt aagcgcgtgg     4320

attgaaacaa ccgggcagac gaagaaatca ccgaagaaga aagtcgcatc ttgcgtaagc     4380

gcgtggattg aaacttccat cagtccatga cgaacggcta gggagcctgt cgcatcttgc     4440

gtaagcgcgt ggattgaaac atggcatcgt tttcgttatc aaccaatatc ttcgtcgcat     4500

ctcgcgtagg cgcgtggatt gaaactaatg atgtgcgatt gacgtattgt ctggcaacgt     4560

gtcgcatctt gcgtaagcgc gtggattgaa acccatttaa ccttatacag agcattatta     4620

cacaagtcgc atcttgcgta agcgcgtgga ttgaaacagt aatcgaaaaa gtgagctttg     4680

agtcggataa cacatattgg accatatagt ctcgaaggat ctcatgaaat taataacggc     4740

ttgtatgcaa ggaacaataa taaaaaaaca ataaaactta gcaccgccag gatttcgttt     4800

ttagcaattt taaatttata atggtaatcg ttttcgctgg acacttcgag tcgcgtttgt     4860

atttcatcgg tatgctgcaa agaattggcg ataaatgcag ccagaatgtt ggacaattct     4920

tttagtttgg atttaaaacc aagatcgtta ttcttaaaaa cctgccgtac ctgctccaaa     4980

atatcctgtt tgaattgact tacagaccgg gtcaattcgt tcactataac ccttgccata     5040

tgcaaatgtt ttgccaccgg aatacccagt gaatttaagg gagaaaggac cttgctcagc     5100

atttctgtga tgggctgaat aggagtagtg aaaaaataca agctgccgat ataccag        5157


<210>  45
<211>  3588
<212>  DNA
<213>  Clostridium novyi

<400>  45
tacaagtcca ctttatgaaa aataagtaaa aaaatcaaca taatatttat tgaatagatt       60

atgaatttaa ttaaagaata atctattctt tgttcaataa aatcatcagg gattattctt      120

agatacgtga aatttataat tttaacaagt tgcatgtata atctgaacaa taatattaag      180

ggaagtggtt aatttggcaa atataaaata tgaaattaca aaatatccat aatggaaaaa      240

ccaccataag ggatattttg tagtctttaa tgggctaaag gcctaaagtt gaagtacaag      300

aaaatcatat tctacttcaa ctagaatatt aacaaggata aaatggactt gcttaacatc      360

tgaaagaaaa acatttcaga tataaagcag gtccattttt tataaaattt aattataata      420

caatatattt gacgttaaat atgttaaaat agtaaataat tataagagaa tttaaggttg      480

aatataaagg ggagaaactt atgattacag ttagaaaaat aaagttaaca ataatgggag      540

ataaagatac aagaaatagt caatacaaat ggattagaga tgaacaatac aatcagtaca      600

gagctttaaa tatgggtatg acttatttag ctgtaaatga tattttatat atgaatgaaa      660

gcggattaga aattcgaact attaaagatt taaaagattg tgaaaaagat attgataaaa      720

ataaaaaaga aattgaaaag ttaactgcaa gactagagaa ggaacaaaat aagaaaaatt      780

cctcatcaga aaaattagat gagattaaat ataaaataag tttagtagaa aataaaattg      840

aagattataa attaaaaata gttgagttaa ataaaattct tgaagaaaca caaaaagaaa      900

gaatggatat acagaaagaa tttaaagaaa aatatgtaga tgatctttat caagttttag      960

ataaaatacc ctttaagcat ttagacaata aaagtctagt tactcaaaga ataaaagctg     1020

atataaagtc agataaaagt aatggactat taaaaggtga aagaagtatt agaaactaca     1080

agagaaactt tcctttaatg actagaggac gagatttaaa atttaaatat gatgataatg     1140

atgatattga aataaagtgg atggaaggaa ttaaatttaa agttattttg ggaaatagaa     1200

taaaaaattc cttagagctt agacacactt tacataaagt tatagaggga aaatataaaa     1260

tatgtgatag tagtttgcaa tttgataaaa ataataatct tatacttaat ttaactctag     1320

acattcctat tgatattgta aataaaaaag tttcaggaag agttgtagga gtagatttag     1380

gattaaagat accagcatat tgtgcattaa atgatgttga atatattaaa aaatctatag     1440

gacgtataga tgatttcttg aaagttagaa ctcaaatgca gagtagaaga agaagacttc     1500

aaattgcaat acaaagtgct aaaggtggaa aaggtagggt gaataaactt caagccttgg     1560

agagatttgc tgaaaaggag aagaattttg caaagacata taatcatttt ttaagttcta     1620

atatagttaa atttgcagtt agcaatcagg ccgaacaaat taatatggag ttattaagtt     1680

taaaagaaac tcaaaataag tcaatactaa gaaattggag ttattatcaa cttcaaacaa     1740

tgattgagta taaagcccaa cgtgaaggga ttaaagttaa gtacatagat ccttatcata     1800

catcacaaac atgtagtaaa tgtggtaatt atgaagaagg acaaagagaa tctcaagctg     1860

attttatatg caaaaaatgt ggttataaag ttaatgctga ttataatgca gctagaaata     1920

tcgctatgag taataaatat ataacaaaaa aagaagaaag taagtattac aaaattaaag     1980

aaagtatggt ataataaaac atagttaaac taataaaaac agggcgattt aacgtcctaa     2040

ggctgagaga agttttttct actcggcaag ggttaatctc gattgttgtg ttaccgatcg     2100

agcgtttcac aaaatgcgag agaaatctcg catttttaat tttgcagtaa ggctagtttt     2160

tatataaata tgctataacc attgatattg ctaggctaca ataggtttta ttaaaaaagc     2220

aaaaaacatt actgaaggtt cactgcaaaa tagtgtattt aagtgaaagt gagattgctt     2280

gtaaagctag gagtatcaat atatttataa atttcaaaat ttagggtttt agtttaacta     2340

tgtgaaatgt aaatatgtaa taaatataaa taataaatat aaataactat gttttagttt     2400

aactatgtga aatgtaaata attagatggt gttttaatct ccatttattc ggttctgttt     2460

tagtttaact atgtgaaatg taaatgaatg aaatatataa taaaatagta aaataaaata     2520

taagttttag tttaactatg tgaaatgtaa atatgtccat tacttctata actgttgagg     2580

ttggctatct gttttagttt aactatgtga aatgtaaatt ttagtacttg ctgtccagct     2640

acaaatccag tagcatgttt tagtttaact atgtgaaatg taaataatgt ttcagcttgt     2700

acttttttag cgtttaaaat taagttttag tttaactatg tgaaatgtaa atatcccaat     2760

ctaatttaga atcttgggac tggtctacgt gttttagttt aactatgtga aatgtaaatt     2820

gggaacacgt ttcatttaca tttagtatag aaggaggttt tagtttaact atgtgaaatg     2880

taaattagtt agcccattca cctcttgctt tctttgcagc aataccgttt tagtttaact     2940

atgtgaaatg taaatctttc ggttcttgta ttttaattat gttatctttt ttctgtttta     3000

gtttaactat gtgaaatgta aatcagatac agacttagaa aaagctccaa cagaagaagg     3060

ttttagttta actatgtgaa atgtgaatga gcatagcaat aaatttcgtt tcattttgtt     3120

tgagtaagtt ttagtaaaat actatgaagt gaagggatac gtattatgaa atttatcgaa     3180

tcaatagatc cttttttgat gcagttggtt attgttccgc taatagtaat tggattaggt     3240

gttttagtag cttataatat taaaaatata ttaattggac ctttaataac attgttttta     3300

aatagtttat atgaaatttg gtatataaaa cactattgtc ctggatcaga aattagtttg     3360

agttcttgga atattattct tccaatgatt tcatttacaa tttctttgat tgtagtatta     3420

attagagaat agggtaatat ttaataaaga ttatttctta ggctaggtga aatgtaaata     3480

acctggattt tctttagttg caataatatc aatactaggt tttagtttaa ctatgtgaaa     3540

tagagaagca gaatataaaa gctgaaacta caaactctcc atcatgga                  3588


<210>  46
<211>  38
<212>  DNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  46
gtttcagcgc acgaattaac gagatgagag atgcaact                               38


<210>  47
<211>  37
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  47
attgcagaac ccaaagtaat aggtcaagga atgcaac                                37


<210>  48
<211>  37
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Aureabacteria bacterium

<400>  48
gttgcagatg tggagaaata gagataacga atgcaac                                37


<210>  49
<211>  37
<212>  DNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  49
gttgcagaac ccgaatagac gaatgaagga atgcaac                                37


<210>  50
<211>  37
<212>  DNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  50
gttgcacagt gctaattaga gaaactagga atgcaac                                37


<210>  51
<211>  37
<212>  DNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  51
gttgcagaac ccgaatagac gaatgaagga atgcaac                                37


<210>  52
<211>  30
<212>  DNA
<213>  Parageobacillus thermoglucosidasius

<400>  52
gtttctgaag aaactatgta tgatgtgaag                                        30


<210>  53
<211>  29
<212>  DNA
<213>  Acidibacillus sulfuroxidans

<400>  53
gtttgcgagc tagcttgtgg agtgtgaac                                         29


<210>  54
<211>  32
<212>  DNA
<213>  Ruminococcus sp.

<400>  54
gttgcaactt acgcataggt gtaaaatacg ag                                     32


<210>  55
<211>  32
<212>  DNA
<213>  Syntrophomonas palmitatica

<400>  55
gtcgcatctt gcgtaagcgc gtggattgaa ac                                     32


<210>  56
<211>  29
<212>  DNA
<213>  Clostridium novyi

<400>  56
gttttagttt aactatgtga aatgtaaat                                         29


<210>  57
<211>  58
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 1 crRNA


<220>
<221>  misc_feature
<222>  (39)..(58)
<223>  n is a, c, g, or u

<400>  57
guuucagcgc acgaauuaac gagaugagag augcaacunn nnnnnnnnnn nnnnnnnn         58


<210>  58
<211>  57
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 2 crRNA


<220>
<221>  misc_feature
<222>  (38)..(57)
<223>  n is a, c, g, or u

<400>  58
auugcagaac ccaaaguaau aggucaagga augcaacnnn nnnnnnnnnn nnnnnnn          57


<210>  59
<211>  57
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 crRNA


<220>
<221>  misc_feature
<222>  (38)..(57)
<223>  n is a, c, g, or u

<400>  59
auugcagaac ccaaaguaau aggucaagga augcaacnnn nnnnnnnnnn nnnnnnn          57


<210>  60
<211>  110
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  60
uuuacuccga guaaucggau guggauuaua gcacagcaac cuauauggaa gcugggaacc       60

gguuuauccg gaaaugcgca ccguugcaug gaauuaugug cgcuuaagac                 110


<210>  61
<211>  85
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  61
uuauagcaca gcaaccuaua uggaagcugg gaaccgguuu auccggaaau gcgcaccguu       60

gcauggaauu augugcgcuu aagac                                             85


<210>  62
<211>  77
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  62
cagcaaccua uauggaagcu gggaaccggu uuauccggaa augcgcaccg uugcauggaa       60

uuaugugcgc uuaagac                                                      77


<210>  63
<211>  69
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  63
uauauggaag cugggaaccg guuuauccgg aaaugcgcac cguugcaugg aauuaugugc       60

gcuuaagac                                                               69


<210>  64
<211>  214
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  64
aaaagauaaa uauuaagaag cacauaauuu auuuugguua cauaucacug gauaaugaga       60

acagcuguag auuaagcugu uugauguauu guauuaugcu ccacuuuaau aaguggugcc      120

uuccaaagcu auaugcugag ggaggauggg cgcuguugca gcgucugccc accucagagu      180

ggguauccuu accuauuuug aaagguucug uaag                                  214


<210>  65
<211>  163
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  65
auaaugagaa cagcuguaga uuaagcuguu ugauguauug uauuaugcuc cacuuuaaua       60

aguggugccu uccaaagcua uaugcugagg gaggaugggc gcuguugcag cgucugccca      120

ccucagagug gguauccuua ccuauuuuga aagguucugu aag                        163


<210>  66
<211>  148
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  66
auaaugagaa cagcuguaga uuaagcuguu ugauguauug uauuaugcuc cacuuuaaua       60

aguggugccu uccaaagcua uaugcugagg gaggaugggc gcuguugcag cgucugccca      120

ccucagagug gguauccuua ccuauuuu                                         148


<210>  67
<211>  127
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  67
auuguauuau gcuccacuuu aauaaguggu gccuuccaaa gcuauaugcu gagggaggau       60

gggcgcuguu gcagcgucug cccaccucag aguggguauc cuuaccuauu uugaaagguu      120

cuguaag                                                                127


<210>  68
<211>  161
<212>  RNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  68
cuucacugau aaaguggaga accgcuucac caaaagcugu cccuuagggg auuagaacuu       60

gagugaaggu gggcugcuug caucagccua augucgagaa gugcuuucuu cggaaaguaa      120

cccucgaaac aaauucauuu uuccucucca auucugcaca a                          161


<210>  69
<211>  172
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 1 sgRNA version 1


<220>
<221>  misc_feature
<222>  (153)..(172)
<223>  n is a, c, g, or u

<400>  69
uuuacuccga guaaucggau guggauuaua gcacagcaac cuauauggaa gcugggaacc       60

gguuuauccg gaaaugcgca ccguugcaug gaauuaugug cgcuuaagac gaaaguuuca      120

gcgcacgaau uaacgagaug agagaugcaa cunnnnnnnn nnnnnnnnnn nn              172


<210>  70
<211>  147
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 1 sgRNA version 2


<220>
<221>  misc_feature
<222>  (128)..(147)
<223>  n is a, c, g, or u

<400>  70
uuauagcaca gcaaccuaua uggaagcugg gaaccgguuu auccggaaau gcgcaccguu       60

gcauggaauu augugcgcuu aagacgaaag uuucagcgca cgaauuaacg agaugagaga      120

ugcaacunnn nnnnnnnnnn nnnnnnn                                          147


<210>  71
<211>  139
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 1 sgRNA version 3


<220>
<221>  misc_feature
<222>  (120)..(139)
<223>  n is a, c, g, or u

<400>  71
cagcaaccua uauggaagcu gggaaccggu uuauccggaa augcgcaccg uugcauggaa       60

uuaugugcgc uuaagacgaa aguuucagcg cacgaauuaa cgagaugaga gaugcaacun      120

nnnnnnnnnn nnnnnnnnn                                                   139


<210>  72
<211>  131
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 1 sgRNA version 4


<220>
<221>  misc_feature
<222>  (112)..(131)
<223>  n is a, c, g, or u

<400>  72
uauauggaag cugggaaccg guuuauccgg aaaugcgcac cguugcaugg aauuaugugc       60

gcuuaagacg aaaguuucag cgcacgaauu aacgagauga gagaugcaac unnnnnnnnn      120

nnnnnnnnnn n                                                           131


<210>  73
<211>  275
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 2 sgRNA version 1


<220>
<221>  misc_feature
<222>  (256)..(275)
<223>  n is a, c, g, or u

<400>  73
aaaagauaaa uauuaagaag cacauaauuu auuuugguua cauaucacug gauaaugaga       60

acagcuguag auuaagcugu uugauguauu guauuaugcu ccacuuuaau aaguggugcc      120

uuccaaagcu auaugcugag ggaggauggg cgcuguugca gcgucugccc accucagagu      180

ggguauccuu accuauuuug aaagguucug uaaggaaaau ugcagaaccc aaaguaauag      240

gucaaggaau gcaacnnnnn nnnnnnnnnn nnnnn                                 275


<210>  74
<211>  224
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 2 sgRNA version 2


<220>
<221>  misc_feature
<222>  (205)..(224)
<223>  n is a, c, g, or u

<400>  74
auaaugagaa cagcuguaga uuaagcuguu ugauguauug uauuaugcuc cacuuuaaua       60

aguggugccu uccaaagcua uaugcugagg gaggaugggc gcuguugcag cgucugccca      120

ccucagagug gguauccuua ccuauuuuga aagguucugu aaggaaaauu gcagaaccca      180

aaguaauagg ucaaggaaug caacnnnnnn nnnnnnnnnn nnnn                       224


<210>  75
<211>  196
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 2 sgRNA version 3


<220>
<221>  misc_feature
<222>  (177)..(196)
<223>  n is a, c, g, or u

<400>  75
auaaugagaa cagcuguaga uuaagcuguu ugauguauug uauuaugcuc cacuuuaaua       60

aguggugccu uccaaagcua uaugcugagg gaggaugggc gcuguugcag cgucugccca      120

ccucagagug gguauccuua ccuauuuuga aaaaguaaua ggucaaggaa ugcaacnnnn      180

nnnnnnnnnn nnnnnn                                                      196


<210>  76
<211>  188
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 2 sgRNA version 4


<220>
<221>  misc_feature
<222>  (169)..(188)
<223>  n is a, c, g, or u

<400>  76
auuguauuau gcuccacuuu aauaaguggu gccuuccaaa gcuauaugcu gagggaggau       60

gggcgcuguu gcagcgucug cccaccucag aguggguauc cuuaccuauu uugaaagguu      120

cuguaaggaa aauugcagaa cccaaaguaa uaggucaagg aaugcaacnn nnnnnnnnnn      180

nnnnnnnn                                                               188


<210>  77
<211>  222
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 sgRNA version 1


<220>
<221>  misc_feature
<222>  (203)..(222)
<223>  n is a, c, g, or u

<400>  77
cuucacugau aaaguggaga accgcuucac caaaagcugu cccuuagggg auuagaacuu       60

gagugaaggu gggcugcuug caucagccua augucgagaa gugcuuucuu cggaaaguaa      120

cccucgaaac aaauucauuu uuccucucca auucugcaca agaaaguugc agaacccgaa      180

uagacgaaug aaggaaugca acnnnnnnnn nnnnnnnnnn nn                         222


<210>  78
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  T2 spacer

<400>  78
agttgaccca acgtcgccgg cgtgcacaat ctagat                                 36


<210>  79
<211>  5100
<212>  DNA
<213>  Artificial

<220>
<223>  Complete Cas-alpha 1 locus engineered to target T2

<400>  79
tcgcgtctat ggcgtgattt tgcagcttcc ctaaattcag ccccttctcc tcaaagccca       60

gaagctcctt taatgcctgc tcgtttgcgc cctccacctt tgagcccggg gcggcgggga      120

agatgctgcg caccaatctt ccttccttgt agactccaag cgccctaacc cttgcgatta      180

catactccca gtccgcagtc gggaaattct gcggcatcgg ggagcctttc tcgtactctg      240

aaacgctttc cgcatgctca aaatagcggt ttgcgcgcat tatctcggaa attgtgccaa      300

aaagcattcc atcctcgcag cgtgtctgga cgaactgccc cttccttaca ttcggggagg      360

agattacgaa ggagaagaag gaggtggtgg ggctgtctat tgtggagatg accgtgccaa      420

gggaggtgga atccatgaag aggttttgag gagaaaatta atatatggaa ttgagggggg      480

tcggacttct accctgtaag tgtttataag gagaactcca tatatacttc ggatatgcaa      540

ctaataattg acgattatgg cgcatatctt gggcagaagg acaacctctt ccaaataagg      600

aagaaagacg ggacgtgtga agaatattct gccgacaagg ttgagcagat acttcttgtg      660

aaaaatagct gtatttcttc aagagccgca ctcttggcag cacgaaacaa catagatgta      720

gtgtttgtag gaaaattcgg aatgccggaa ggaaggattt ttcctgcatg tcttggagga      780

acaaatctca taagaagaaa acaacttgaa gcagggcaga atgagaaagg agggaaaatt      840

gcaataaaac ttatctgggc aaagatcaag aatgaggaat ttttccttaa aactctcaac      900

aaaagcagaa ctgcgcctct tcttttggag aaagcggaaa aaataagcgc tattgcggag      960

caagtccggc agatgttagg cgagaaattt gatgcagata gggtttttgg ttttgaagga     1020

ttggctgcgg cgcactattt tgagggattg tcacaggtaa tgccgattga aaagcgcgac     1080

caagagggaa aagatgcccc aaatgcactc ttgaattatg gttatggaat gttgtacgga     1140

gagatagaga aagcctgcct ttttgccggt ttggacccgt atcttggctt tcttcatgca     1200

gataggtacg gcaagccctc tcttgtactt gatttgatag aagagttcag accggttatt     1260

gttgataggg cgattattac gctttacgca cagaaacaga taaacgagag tgattttgag     1320

cagggaggag ataagatttt tctttcaaaa gaagggagaa agaagatgat aaaggcaatt     1380

atggaaagac tgcatgcaaa aataacttca gatgggcgca agcttgagct ttcggtgata     1440

atacaggagc aggcgcgaag aatcgcctcc tttgtgaagg gagagagcga gtttgagcct     1500

tttctttaca ggtggtagga tgttttattg ggtaatttat gatataagcg aaaacaagaa     1560

acgcggcagg gtggcaagaa tatgcaaaaa ctacgggttt agaagagtgc agaagagcgc     1620

ctttgcaggc gaaacttcaa agaataaggt ggagatgctg ttattggaat gcaatgagat     1680

tatagaggga ggggatgatt atttgtttgt cattccgaac tgcacaagct gtttcaatgg     1740

gaaaatgata accggctgtc ttgacgagaa aagagtgaga aatcagccgt atatgtttgt     1800

aggtgatggc gcatgaacag aatgggaatt ttgagcattc gagacatatt gaattacaac     1860

tactgcccgc gcatagtata ttttgagtat gttctgcgca gaccacaggg caggacgaaa     1920

aaggaggatg agggattgaa acagcataat gaatttgtgc caagagggaa gaggaataag     1980

atggttaaac ggatttgtta tgacaagaag ctgtttaatc tgccgcttta ttctccgcgc     2040

atgaaccttc aaactgtggc ggattgcgtg cttattgaca caaaagagaa gcttgctgtt     2100

ccgatgcagt ttaagcatgg aaaaacacct tcttgcttgt atcggactat gaaataccag     2160

cttgtagcgg aggcgttgct gattgaggag tgccttgggc tttcatgtcc ttatggactt     2220

gtgaaattct tacctgaaga aacaactctt agaacagaaa tagacgaaat tcaaaagcaa     2280

aaacttaaag aacagcttga gagtattaac aacgtggtga ggtttgaaag gtatcccgat     2340

ggtccgagaa cgaggaatta ctgcggggac tgctggtatc atggaaaagt ttgcacggga     2400

tttgacggca aaatagtggg atgaacatga gtaaaactac gatttcagta aaattaaaga     2460

ttattgactt aagctctgag aaaaaagagt ttcttgataa ctattttaac gaatacgcaa     2520

aagccacgac gttctgccag ttaagaatac ggcgactttt gagaaataca cactggcttg     2580

ggaaaaagga gaagagttca aaaaagtgga tttttgaaag tggaatatgc gatttgtgcg     2640

gtgaaaacaa agaacttgtg aatgaagata gaaattcagg cgaacctgca aaaatttgca     2700

aaagatgtta taatggaaga tatggcaatc agatgatacg taaacttttc gtttcaacga     2760

agaaaagaga agttcaggaa aacatggaca tacgaagagt cgctaaacta aataatacgc     2820

attatcaccg cataccggaa gaagcatttg acatgattaa agccgccgat acagcagaaa     2880

aaagaagaaa gaagaatgtc gagtatgata aaaaaagaca gatggaattt attgagatgt     2940

ttaatgacga aaaaaaacgt gcggcaagac caaaaaaacc aaacgaaagg gaaacccgtt     3000

acgttcatat ttctaaattg gaaagtccgt caaagggata tactctgaac ggaataaaaa     3060

gaaaaataga cggcatgggt aaaaaaattg agagagcaga aaaaggtctc tcaagaaaga     3120

agatttttgg ttatcagggc aatagaatca aacttgattc gaattgggtc cggtttgacc     3180

ttgccgaatc ggagattact atcccctcac tgtttaagga aatgaaacta aggataactg     3240

gaccgaccaa cgttcattca aaaagcgggc agatatattt tgcagaatgg tttgagcgga     3300

taaacaaaca accgaataat tactgttatc tgataagaaa aacaagttcg aacggcaaat     3360

atgaatatta tcttcaatat acttatgaag ccgaagttga ggcgaataag gagtacgctg     3420

ggtgtttggg ggttgatata ggatgttcta aacttgctgc cgcagtttat tatgattcaa     3480

aaaacaaaaa agcacaaaaa ccaattgaga tattcacgaa tccgattaaa aaaatcaaga     3540

tgcggcgcga gaaactgatt aaacttcttt ccagagttaa ggtgcggcac agacgcagaa     3600

aactcatgca actcagtaaa actgaaccca ttatagacta tacgtgccac aaaaccgcaa     3660

gaaaaattgt tgaaatggca aatactgcca aagcttttat ctcaatggag aatcttgaaa     3720

ctgggataaa gcaaaagcaa caggcaagag aaacaaaaaa gcagaagttt tatcggaata     3780

tgtttctttt cagaaaatta agcaaactaa tagagtacaa ggctctgctg aaagggataa     3840

agatagtata tgtgaaaccc gattatacaa gccaaacttg ttcttcatgt ggcgcagaca     3900

aagaaaaaac cgagcgccca tcacaagcaa tatttcgctg tcttaatcca acatgccgat     3960

attatcaaag agacataaat gccgacttca acgccgcagt gaatatagct aagaaagctt     4020

taaataatac tgaagtagta actacgttat tatgatttac tccgagtaat cggatgtgga     4080

ttatagcaca gcaacctata tggaagctgg gaaccggttt atccggaaat gcgcaccgtt     4140

gcatggaatt atgtgcgctt aagaccttat gatatcgcgc ggcttgactt cgcgatagac     4200

aggtcaacta ttgtctcggt tcaacgtgcc aattagcagg tctttataaa tagcctgcag     4260

attttcaagt tgcttttctt agtgcagaaa agaaggcagg agaagcctcc gtttggcaaa     4320

aaaaggcggt tgtatctact gtttcagcgc acgaattaac gagatgagag atgcaactag     4380

ttgacccaac gtcgccggcg tgcacaatct agatgtttca gcgcacgaat taacgagatg     4440

agagatgcaa ctagttgacc caacgtcgcc ggcgtgcaca atctagatgt ttcagcgcac     4500

gaattaacga gatgagagat gcaactagtt gacccaacgt cgccggcgtg cacaatctag     4560

atgtttcagc gcacgaatta acgagatgag agatgcaact cagtagaaga taaaacagaa     4620

ttagaataag atggcttcca gcctgatggt cgtgctcata accgaattgc tgaagtatac     4680

gtgcaagctc ccttccagaa atgacgggca gtttaggcat gtacctcaac aatttcttcc     4740

cgtattgacg gcggaaccgg ctccccgtgc tttttcaggc tcgcaagata gcccttgatg     4800

gcgtctttaa cgtttgcaag cgcatcttcc ctagttgttc cctgcgaaac acagcccgga     4860

agcgaggtgc aaaccgcgac gtatgcaccg tcttcgtctt cttctacaat caccctgaat     4920

ttcataagta tctttgggct ttttggagtt tataagaatg atggatttgg gaagttgcac     4980

cgcgcggatt agtgggagcc ccgtcatttc ggcgcatcca aaaggagtat aagctccctc     5040

gtttttgctt caaattcctt ttttcttcaa ttccgcaaat ctgcctttgc gggagcttcg     5100


<210>  80
<211>  2237
<212>  DNA
<213>  Artificial

<220>
<223>  Minimal Cas-alpha 1 locus engineered to target T2

<400>  80
atgaacatga gtaaaactac gatttcagta aaattaaaga ttattgactt aagctctgag       60

aaaaaagagt ttcttgataa ctattttaac gaatacgcaa aagccacgac gttctgccag      120

ttaagaatac ggcgactttt gagaaataca cactggcttg ggaaaaagga gaagagttca      180

aaaaagtgga tttttgaaag tggaatatgc gatttgtgcg gtgaaaacaa agaacttgtg      240

aatgaagata gaaattcagg cgaacctgca aaaatttgca aaagatgtta taatggaaga      300

tatggcaatc agatgatacg taaacttttc gtttcaacga agaaaagaga agttcaggaa      360

aacatggaca tacgaagagt cgctaaacta aataatacgc attatcaccg cataccggaa      420

gaagcatttg acatgattaa agccgccgat acagcagaaa aaagaagaaa gaagaatgtc      480

gagtatgata aaaaaagaca gatggaattt attgagatgt ttaatgacga aaaaaaacgt      540

gcggcaagac caaaaaaacc aaacgaaagg gaaacccgtt acgttcatat ttctaaattg      600

gaaagtccgt caaagggata tactctgaac ggaataaaaa gaaaaataga cggcatgggt      660

aaaaaaattg agagagcaga aaaaggtctc tcaagaaaga agatttttgg ttatcagggc      720

aatagaatca aacttgattc gaattgggtc cggtttgacc ttgccgaatc ggagattact      780

atcccctcac tgtttaagga aatgaaacta aggataactg gaccgaccaa cgttcattca      840

aaaagcgggc agatatattt tgcagaatgg tttgagcgga taaacaaaca accgaataat      900

tactgttatc tgataagaaa aacaagttcg aacggcaaat atgaatatta tcttcaatat      960

acttatgaag ccgaagttga ggcgaataag gagtacgctg ggtgtttggg ggttgatata     1020

ggatgttcta aacttgctgc cgcagtttat tatgattcaa aaaacaaaaa agcacaaaaa     1080

ccaattgaga tattcacgaa tccgattaaa aaaatcaaga tgcggcgcga gaaactgatt     1140

aaacttcttt ccagagttaa ggtgcggcac agacgcagaa aactcatgca actcagtaaa     1200

actgaaccca ttatagacta tacgtgccac aaaaccgcaa gaaaaattgt tgaaatggca     1260

aatactgcca aagcttttat ctcaatggag aatcttgaaa ctgggataaa gcaaaagcaa     1320

caggcaagag aaacaaaaaa gcagaagttt tatcggaata tgtttctttt cagaaaatta     1380

agcaaactaa tagagtacaa ggctctgctg aaagggataa agatagtata tgtgaaaccc     1440

gattatacaa gccaaacttg ttcttcatgt ggcgcagaca aagaaaaaac cgagcgccca     1500

tcacaagcaa tatttcgctg tcttaatcca acatgccgat attatcaaag agacataaat     1560

gccgacttca acgccgcagt gaatatagct aagaaagctt taaataatac tgaagtagta     1620

actacgttat tatgatttac tccgagtaat cggatgtgga ttatagcaca gcaacctata     1680

tggaagctgg gaaccggttt atccggaaat gcgcaccgtt gcatggaatt atgtgcgctt     1740

aagaccttat gatatcgcgc ggcttgactt cgcgatagac aggtcaacta ttgtctcggt     1800

tcaacgtgcc aattagcagg tctttataaa tagcctgcag attttcaagt tgcttttctt     1860

agtgcagaaa agaaggcagg agaagcctcc gtttggcaaa aaaaggcggt tgtatctact     1920

gtttcagcgc acgaattaac gagatgagag atgcaactag ttgacccaac gtcgccggcg     1980

tgcacaatct agatgtttca gcgcacgaat taacgagatg agagatgcaa ctagttgacc     2040

caacgtcgcc ggcgtgcaca atctagatgt ttcagcgcac gaattaacga gatgagagat     2100

gcaactagtt gacccaacgt cgccggcgtg cacaatctag atgtttcagc gcacgaatta     2160

acgagatgag agatgcaact cagtagaaga taaaacagaa ttagaataag atggcttcca     2220

gcctgatggt cgtgctc                                                    2237


<210>  81
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  10X His tag

<400>  81

His His His His His His His His His His 
1               5                   10  


<210>  82
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  6X His tag

<400>  82

His His His His His His 
1               5       


<210>  83
<211>  367
<212>  PRT
<213>  Artificial

<220>
<223>  maltose binding protein tag

<400>  83

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr 
        355                 360                 365         


<210>  84
<211>  7
<212>  PRT
<213>  Tobacco etch virus

<400>  84

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  85
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  A1 oligonucleotide

<400>  85
cggcattcct gctgaaccgc tcttccgatc t                                      31


<210>  86
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  A2 oligonucleotide

<400>  86
gatcggaaga gcggttcagc aggaatgccg                                        30


<210>  87
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  R0 oligonucleotide

<400>  87
gccagggttt tcccagtcac ga                                                22


<210>  88
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  C0 oligonucleotide

<400>  88
gaaattctaa acgctaaaga ggaagagg                                          28


<210>  89
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  F1 oligonucleotide

<400>  89
ctacactctt tccctacacg acgctcttcc gatctaaggc ggcattcctg ctgaac           56


<210>  90
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  R1 oligonucleotide

<400>  90
caagcagaag acggcatacg agctcttccg atctcggcga cgttgggtc                   49


<210>  91
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Bridge amplification portion of F1 oligonucleotide

<400>  91
ctacactctt tccctacacg acgctcttcc gatct                                  35


<210>  92
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Bridge amplification portion of R1 oligonucleotide

<400>  92
caagcagaag acggcatacg agctcttccg atct                                   34


<210>  93
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  F2 oligonucleotide

<400>  93
aatgatacgg cgaccaccga gatctacact ctttccctac acg                         43


<210>  94
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  R2 olignonucleotide

<400>  94
caagcagaag acggcata                                                     18


<210>  95
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  C1 oligonucleotide

<400>  95
ctacactctt tccctacacg acgctcttcc gatctggaat aaacgctaaa gaggaagagg       60


<210>  96
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence resulting from cleavage and adapter ligation at position
       21 of the target

<400>  96
ccgctcttcc gatctgccgg cgacgttggg tcaact                                 36


<210>  97
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Adapter portion of SEQ ID NO. 96

<400>  97
ccgctcttcc gatct                                                        15


<210>  98
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Target portion of SEQ ID NO. 96

<400>  98
gccggcgacg ttgggtcaac t                                                 21


<210>  99
<211>  10
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence 5' of PAM

<400>  99
tgtcctcttc                                                              10


<210>  100
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Fixed double stranded DNA target

<400>  100
ttatagttga cccaacgtcg ccggcgtgca caatctagat                             40


<210>  101
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  T2 target sequence

<400>  101
agttgaccca acgtcgccgg cgtgcacaat ctagat                                 36


<210>  102
<211>  222
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 T2-1 sgRNA

<400>  102
cuucacugau aaaguggaga accgcuucac caaaagcugu cccuuagggg auuagaacuu       60

gagugaaggu gggcugcuug caucagccua augucgagaa gugcuuucuu cggaaaguaa      120

cccucgaaac aaauucauuu uuccucucca auucugcaca agaaaguugc agaacccgaa      180

uagacgaaug aaggaaugca acccggcgac guugggucaa cu                         222


<210>  103
<211>  222
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 T2-2 sgRNA

<400>  103
cuucacugau aaaguggaga accgcuucac caaaagcugu cccuuagggg auuagaacuu       60

gagugaaggu gggcugcuug caucagccua augucgagaa gugcuuucuu cggaaaguaa      120

cccucgaaac aaauucauuu uuccucucca auucugcaca agaaaguugc agaacccgaa      180

uagacgaaug aaggaaugca acaguugacc caacgucgcc gg                         222


<210>  104
<211>  57
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 T2-1 crRNA

<400>  104
guugcagaac ccgaauagac gaaugaagga augcaacccg gcgacguugg gucaacu          57


<210>  105
<211>  57
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 T2-1 crRNA

<400>  105
guugcagaac ccgaauagac gaaugaagga augcaacagu ugacccaacg ucgccgg          57


<210>  106
<211>  189
<212>  DNA
<213>  Solanum tuberosum

<400>  106
gtaagtttct gcttctacct ttgatatata tataataatt atcattaatt agtagtaata       60

taatatttca aatatttttt tcaaaataaa agaatgtagt atatagcaat tgcttttctg      120

tagtttataa gtgtgtatat tttaatttat aacttttcta atatatgacc aaaacatggt      180

gatgtgcag                                                              189


<210>  107
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  107

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  108
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  108

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  109
<211>  896
<212>  DNA
<213>  Zea mays

<400>  109
gtgcagcgtg acccggtcgt gcccctctct agagataatg agcattgcat gtctaagtta       60

taaaaaatta ccacatattt tttttgtcac acttgtttga agtgcagttt atctatcttt      120

atacatatat ttaaacttta ctctacgaat aatataatct atagtactac aataatatca      180

gtgttttaga gaatcatata aatgaacagt tagacatggt ctaaaggaca attgagtatt      240

ttgacaacag gactctacag ttttatcttt ttagtgtgca tgtgttctcc tttttttttg      300

caaatagctt cacctatata atacttcatc cattttatta gtacatccat ttagggttta      360

gggttaatgg tttttataga ctaatttttt tagtacatct attttattct attttagcct      420

ctaaattaag aaaactaaaa ctctatttta gtttttttat ttaataattt agatataaaa      480

tagaataaaa taaagtgact aaaaattaaa caaataccct ttaagaaatt aaaaaaacta      540

aggaaacatt tttcttgttt cgagtagata atgccagcct gttaaacgcc gtcgacgagt      600

ctaacggaca ccaaccagcg aaccagcagc gtcgcgtcgg gccaagcgaa gcagacggca      660

cggcatctct gtcgctgcct ctggacccct ctcgagagtt ccgctccacc gttggacttg      720

ctccgctgtc ggcatccaga aattgcgtgg cggagcggca gacgtgagcc ggcacggcag      780

gcggcctcct cctcctctca cggcaccggc agctacgggg gattcctttc ccaccgctcc      840

ttcgctttcc cttcctcgcc cgccgtaata aatagacacc ccctccacac cctctt          896


<210>  110
<211>  278
<212>  DNA
<213>  Gallus gallus

<400>  110
tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa       60

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      120

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      180

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      240

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcg                              278


<210>  111
<211>  286
<212>  DNA
<213>  Human beta herpesvirus 5

<400>  111
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg      120

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      180

cgtcaatgac ggtaaatggc ccgcctggca ttgtgcccag tacatgacct tatgggactt      240

tcctacttgg cagtacatct acgtattagt catcgctatt accatg                     286


<210>  112
<211>  82
<212>  DNA
<213>  Zea mays

<400>  112
tccccaacct cgtgttgttc ggagcgcaca cacacacaac cagatctccc ccaaatccac       60

ccgtcggcac ctccgcttca ag                                                82


<210>  113
<211>  1013
<212>  DNA
<213>  Zea mays

<400>  113
gtacgccgct cgtcctcccc cccccccctc tctaccttct ctagatcggc gttccggtcc       60

atgcatggtt agggcccggt agttctactt ctgttcatgt ttgtgttaga tccgtgtttg      120

tgttagatcc gtgctgctag cgttcgtaca cggatgcgac ctgtacgtca gacacgttct      180

gattgctaac ttgccagtgt ttctctttgg ggaatcctgg gatggctcta gccgttccgc      240

agacgggatc gatttcatga ttttttttgt ttcgttgcat agggtttggt ttgccctttt      300

cctttatttc aatatatgcc gtgcacttgt ttgtcgggtc atcttttcat gctttttttt      360

gtcttggttg tgatgatgtg gtctggttgg gcggtcgttc tagatcggag tagaattctg      420

tttcaaacta cctggtggat ttattaattt tggatctgta tgtgtgtgcc atacatattc      480

atagttacga attgaagatg atggatggaa atatcgatct aggataggta tacatgttga      540

tgcgggtttt actgatgcat atacagagat gctttttgtt cgcttggttg tgatgatgtg      600

gtgtggttgg gcggtcgttc attcgttcta gatcggagta gaatactgtt tcaaactacc      660

tggtgtattt attaattttg gaactgtatg tgtgtgtcat acatcttcat agttacgagt      720

ttaagatgga tggaaatatc gatctaggat aggtatacat gttgatgtgg gttttactga      780

tgcatataca tgatggcata tgcagcatct attcatatgc tctaaccttg agtacctatc      840

tattataata aacaagtatg ttttataatt attttgatct tgatatactt ggatgatggc      900

atatgcagca gctatatgtg gattttttta gccctgcctt catacgctat ttatttgctt      960

ggtactgttt cttttgtcga tgctcaccct gttgtttggt gttacttctg cag            1013


<210>  114
<211>  228
<212>  DNA
<213>  Artificial

<220>
<223>  hybrid intron

<400>  114
ggagtcgctg cgcgctgcct tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg       60

ccccggctct gactgaccgc gttactccca caggtgagcg ggcgggacgg cccttctcct      120

ccgggctgta attagctgag caagaggtaa gggtttaagg gatggttggt tggtggggta      180

ttaatgttta attacctgga gcacctgcct gaaatcactt tttttcag                   228


<210>  115
<211>  1000
<212>  DNA
<213>  Zea mays

<400>  115
tgagagtaca atgatgaacc tagattaatc aatgccaaag tctgaaaaat gcaccctcag       60

tctatgatcc agaaaatcaa gattgcttga ggccctgttc ggttgttccg gattagagcc      120

ccggattaat tcctagccgg attacttctc taatttatat agattttgat gagctggaat      180

gaatcctggc ttattccggt acaaccgaac aggccctgaa ggataccagt aatcgctgag      240

ctaaattggc atgctgtcag agtgtcagta ttgcagcaag gtagtgagat aaccggcatc      300

atggtgccag tttgatggca ccattagggt tagagatggt ggccatgggc gcatgtcctg      360

gccaactttg tatgatatat ggcagggtga ataggaaagt aaaattgtat tgtaaaaagg      420

gatttcttct gtttgttagc gcatgtacaa ggaatgcaag ttttgagcga gggggcatca      480

aagatctggc tgtgtttcca gctgtttttg ttagccccat cgaatccttg acataatgat      540

cccgcttaaa taagcaacct cgcttgtata gttccttgtg ctctaacaca cgatgatgat      600

aagtcgtaaa atagtggtgt ccaaagaatt tccaggccca gttgtaaaag ctaaaatgct      660

attcgaattt ctactagcag taagtcgtgt ttagaaatta tttttttata tacctttttt      720

ccttctatgt acagtaggac acagtgtcag cgccgcgttg acggagaata tttgcaaaaa      780

agtaaaagag aaagtcatag cggcgtatgt gccaaaaact tcgtcacaga gagggccata      840

agaaacatgg cccacggccc aatacgaagc accgcgacga agcccaaaca gcagtccgta      900

ggtggagcaa agcgctgggt aatacgcaaa cgttttgtcc caccttgact aatcacaaga      960

gtggagcgta ccttataaac cgagccgcaa gcaccgaatt                           1000


<210>  116
<211>  249
<212>  DNA
<213>  Homo sapiens

<400>  116
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacacc                                                              249


<210>  117
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Strep II tag

<400>  117

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  118
<211>  208
<212>  DNA
<213>  Bos taurus

<400>  118
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagagaa tagcaggcat gctgggga                                         208


<210>  119
<211>  317
<212>  DNA
<213>  Solanum tuberosum

<400>  119
agacttgtcc atcttctgga ttggccaact taattaatgt atgaaataaa aggatgcaca       60

catagtgaca tgctaatcac tataatgtgg gcatcaaagt tgtgtgttat gtgtaattac      120

tagttatctg aataaaagag aaagagatca tccatatttc ttatcctaaa tgaatgtcac      180

gtgtctttat aattctttga tgaaccagat gcatttcatt aaccaaatcc atatacatat      240

aaatattaat catatataat taatatcaat tgggttagca aaacaaatct agtctaggtg      300

tgttttgcga atgcggc                                                     317


<210>  120
<211>  113
<212>  DNA
<213>  Zea mays

<400>  120
cctatagtac actagtaagg tgcatgtgct aacaatatga caaatctagt atttctttat       60

agtttatcat ccataaatcg caaaatacct aagcataatt ttatttgaat aga             113


<210>  121
<211>  83
<212>  DNA
<213>  Zea mays

<400>  121
cctatagtac actagtaagg tgcatgtgct aacaatacat ccataaatcg caaaatacct       60

aagcataatt ttatttgaat aga                                               83


<210>  122
<211>  104
<212>  DNA
<213>  Zea mays

<400>  122
cctatagtac actagtaagg tgcatgtgct aacaatatga caaatctggt atttctttat       60

agtttaaatc gcaaaatacc taagcataat tttatttgaa taga                       104


<210>  123
<211>  110
<212>  DNA
<213>  Zea mays

<400>  123
cctatagtac actagtaagg tgcatgtgct aacaatatga caaatctagt atttctttat       60

agtttatcca taaatcgcaa aatacctaag cataatttta tttgaataga                 110


<210>  124
<211>  110
<212>  DNA
<213>  Zea mays

<400>  124
cctatagtac actagtaagg tgcatgtgct aacaatatga caaatctagt atttcatagt       60

ttatcatcca taaatcgcaa aatacctaag cataatttta tttgaataga                 110


<210>  125
<211>  110
<212>  DNA
<213>  Zea mays

<400>  125
cctatagtac actagtaagg tgcatgtgct aacaatatga caaatctagt atttctttat       60

agtttatcca taaatcgcaa aatacctaag cataatttta tttgaataga                 110


<210>  126
<211>  113
<212>  DNA
<213>  Homo sapiens

<400>  126
gggcaaagtg agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg agccctcccc       60

cttgggatcc cgcagctgac cagtcgcgct gacggacaga cagacagaca ccg             113


<210>  127
<211>  111
<212>  DNA
<213>  Homo sapiens

<400>  127
gggcaaagtg agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg ccctccccct       60

tgggatcccg cagctgacca gtcgcgctga cggacagaca gacagacacc g               111


<210>  128
<211>  107
<212>  DNA
<213>  Homo sapiens

<400>  128
gggcaaagtg agtgacctgc ttttgggggt gaccgccgga gcgcggccct cccccttggg       60

atcccgcagc tgaccagtcg cgctgacgga cagacagaca gacaccg                    107


<210>  129
<211>  111
<212>  DNA
<213>  Homo sapiens

<400>  129
gggcaaagtg agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg ccctccccct       60

tgggatcccg cagctgacca gtcgcgctga cggacagaca gacagacacc g               111


<210>  130
<211>  111
<212>  DNA
<213>  Homo sapiens

<400>  130
gggcaaagtg agtgacctgc ttttgggggt gaccgccgga gcgcggcgag ccctccccct       60

tgggatcccg cagctgacca gtcgcgctga cggacagaca gacagacacc g               111


<210>  131
<211>  112
<212>  DNA
<213>  Homo sapiens

<400>  131
gggcaaagtg agtgacctgc ttttgggggt gaccgccgga gcgcggcgta gccctccccc       60

ttgggatccc gcagctgacc agtcgcgctg acggacagac agacagacac cg              112


<210>  132
<211>  113
<212>  DNA
<213>  Homo sapiens

<400>  132
cccccacccc ctttccaaag cccattccct ctttagccag agccggggtg tgcagacggc       60

agtcactagg gggcgctcgg ccaccacagg gaagctgggt gaatggagcg agc             113


<210>  133
<211>  111
<212>  DNA
<213>  Homo sapiens

<400>  133
cccccacccc ctttccaaag cccattccct ctttagccag agccggggtg tgcagacggg       60

tcactagggg gcgctcggcc accacaggga agctgggtga atggagcgag c               111


<210>  134
<211>  101
<212>  DNA
<213>  Homo sapiens

<400>  134
cccccacccc ctttccaaag cccattccct ctttagccag agccgggcag tcactagggg       60

gcgctcggcc accacaggga agctgggtga atggagcgag c                          101


<210>  135
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  135
cccccacccc ctttccaaag cccattccct ctttagccag agccggggtg tgcagacagt       60

cactaggggg cgctcggcca ccacagggaa gctgggtgaa tggagcgagc                 110


<210>  136
<211>  600
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  136
gcgtattacc ttctgctgga ttcaaacact cttctccagt aaaaagattc ccttctcact       60

ctgcttagag aaggagtgcc aggccggcta agcccactct ccagacggaa accatacaat      120

gcctccgctg gctgcattgt cgcgccccgc ccaacgacgg tttaccgaca gctgctagct      180

gggctcaaca ggtggttagc ccaccaattc ccctgtcgct cttcgctctg aatgtgacgg      240

caaatttcga cccgttgttc ctgttccttt tttttttcaa ttggactgaa aaaaaaaaag      300

aaccgaatct ggaaagatac acccaaacat acatagaatg tacggatgca tgattgtctc      360

agcctcgttt ggctcatcgt tcttcatttc tttttcctaa ttttgataga gacaatagat      420

agacgtggaa ggaaaaaaaa aaggaaagcc caacaatatt gagaaacgaa gaggtgtatt      480

tggtttaaat agagcctctt cattcctttc ctgatctgac aacagggtgg aacataaaat      540

atagatctgt agtgagtgcg aatagcaata gtaagtgaac gaaaaaggaa tacgataata      600


<210>  137
<211>  466
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  137
tgaagtacgg attagaagcc gccgagcggg tgacagccct ccgaaggaag actctcctcc       60

gtgcgtcctc gtcttcaccg gtcgcgttcc tgaaacgcag atgtgcctcg cgccgcactg      120

ctccgaacaa taaagattct acaatactag cttttatggt tatgaagagg aaaaattggc      180

agtaacctgg ccccacaaac cttcaaatga acgaatcaaa ttaacaacca taggatgata      240

atgcgattag ttttttagcc ttatttctgg ggtaattaat cagcgaagcg atgatttttg      300

atctattaac agatatataa atgcaaaaac tgcataacca ctttaactaa tactttcaac      360

attttcggtt tgtattactt cttattcaaa tgtaataaaa gtatcaacaa aaaattgtta      420

atatacctct atactttaac gtcaaggaga aaaaaccccg gattct                     466


<210>  138
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  HH Ribozyme (where N represents nucleotides that are 
       complementary to the 6 nucleotides 3' of ribozyme)


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  n is a, c, g, or t

<400>  138
nnnnnnctga tgagtccgtg aggacgaaac gagtaagctc gtc                         43


<210>  139
<211>  68
<212>  DNA
<213>  Hepatitis delta virus

<400>  139
ggccggcatg gtcccagcct cctcgctggc gccggctggg caacatgctt cggcatggcg       60

aatgggac                                                                68


<210>  140
<211>  269
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  140
tctttgaaaa gataatgtat gattatgctt tcactcatat ttatacagaa acttgatgtt       60

ttctttcgag tatatacaag gtgattacat gtacgtttga agtacaactc tagattttgt      120

agtgccctct tgggctagcg gtaaaggtgc gcattttttc acaccctaca atgttctgtt      180

caaaagattt tggtcaaacg ctgtagaagt gaaagttggt gcgcatgttt cggcgttcga      240

aacttctccg cagtgaaaga taaatgatc                                        269


<210>  141
<211>  20
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  141
tttttttgtt ttttatgtct                                                   20


<210>  142
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  5' to 3' top strand of target sequence Cas-alpha4 cleavage

<400>  142
ccaacgtcgc cggcgtgcac aatct                                             25


<210>  143
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  3' to 5' bottom strand of target sequence Cas-alpha4 cleavage

<400>  143
agattgtgca cgccggcgac gttgg                                             25


<210>  144
<211>  57
<212>  DNA
<213>  Zea mays

<400>  144
ccacgacggg cgttccttgc gcagctgtgc tcgacgttgt cactgaagcg ggaaggg          57


<210>  145
<211>  46
<212>  DNA
<213>  Zea mays

<400>  145
ccacgacggg cgttccttgc gcagctgtgc actgaagcgg gaaggg                      46


<210>  146
<211>  47
<212>  DNA
<213>  Zea mays

<400>  146
ccacgacggg cgttccttgc gcagctgtgt cactgaagcg ggaaggg                     47


<210>  147
<211>  45
<212>  DNA
<213>  Zea mays

<400>  147
ccacgacggg cgttccttgc gcagctgtgg ctgaagcggg aaggg                       45


<210>  148
<211>  48
<212>  DNA
<213>  Zea mays

<400>  148
ccacgacggg cgttccttgc gcagctgtgc tcactgaagc gggaaggg                    48


<210>  149
<211>  45
<212>  DNA
<213>  Zea mays

<400>  149
ccacgacggg cgttccttgc gcagctgtga ctgaagcggg aaggg                       45


<210>  150
<211>  54
<212>  DNA
<213>  Zea mays

<400>  150
ccacgacggg cgttccttgc gcagctgtgc tcgatgtcac tgaagcggga aggg             54


<210>  151
<211>  45
<212>  DNA
<213>  Zea mays

<400>  151
ccacgacggg cgttccttgc gcagctgtca ctgaagcggg aaggg                       45


<210>  152
<211>  43
<212>  DNA
<213>  Zea mays

<400>  152
ccacgacggg cgttccttgc gcagctcact gaagcgggaa ggg                         43


<210>  153
<211>  41
<212>  DNA
<213>  Zea mays

<400>  153
ccacgacggg cgttccttgc gcagcactga agcgggaagg g                           41


<210>  154
<211>  50
<212>  DNA
<213>  Zea mays

<400>  154
ccacgacggg cgttccttgc gcagctgtgc tgtcactgaa gcgggaaggg                  50


<210>  155
<211>  48
<212>  DNA
<213>  Zea mays

<400>  155
ccacgacggg cgttccttgc gcagctgtgg tcactgaagc gggaaggg                    48


<210>  156
<211>  44
<212>  DNA
<213>  Zea mays

<400>  156
ccacgacggg cgttccttgc gcagctgcac tgaagcggga aggg                        44


<210>  157
<211>  49
<212>  DNA
<213>  Zea mays

<400>  157
ccacgacggg cgttccttgc gcagctgtgc tcgactgaag cgggaaggg                   49


<210>  158
<211>  38
<212>  DNA
<213>  Zea mays

<400>  158
ccacgacggg cgttccttgc gcagctgtgc gggaaggg                               38


<210>  159
<211>  49
<212>  DNA
<213>  Zea mays

<400>  159
ccacgacggg cgttccttgc gcagctgtgc ttcactgaag cgggaaggg                   49


<210>  160
<211>  47
<212>  DNA
<213>  Zea mays

<400>  160
ccacgacggg cgttccttgc gcagctgtga cactgaagcg ggaaggg                     47


<210>  161
<211>  47
<212>  DNA
<213>  Zea mays

<400>  161
ccacgacggg cgttccttgc gcagctgtgc cactgaagcg ggaaggg                     47


<210>  162
<211>  45
<212>  DNA
<213>  Zea mays

<400>  162
ccacgacggg cgttccttgc gcagctgtgc ctgaagcggg aaggg                       45


<210>  163
<211>  38
<212>  DNA
<213>  Zea mays

<400>  163
ccacgacggg cgttccttgc gcagctgagc gggaaggg                               38


<210>  164
<211>  84
<212>  DNA
<213>  Zea mays

<400>  164
tccgcaacgc gtcgccgttc aagttcacgg cgttccaggc ggggccgagg atctgcctgg       60

gcaaggactc ggcgtacctg caga                                              84


<210>  165
<211>  75
<212>  DNA
<213>  Zea mays

<400>  165
tccgcaacgc gtcgccgttc aagttcacgg cgttcccgag gatctgcctg ggcaaggact       60

cggcgtacct gcaga                                                        75


<210>  166
<211>  77
<212>  DNA
<213>  Zea mays

<400>  166
tccgcaacgc gtcgccgttc aagttcacgg cgttcggccg aggatctgcc tgggcaagga       60

ctcggcgtac ctgcaga                                                      77


<210>  167
<211>  78
<212>  DNA
<213>  Zea mays

<400>  167
tccgcaacgc gtcgccgttc aagttcacgg cgttccagcc gaggatctgc ctgggcaagg       60

actcggcgta cctgcaga                                                     78


<210>  168
<211>  76
<212>  DNA
<213>  Zea mays

<400>  168
tccgcaacgc gtcgccgttc aagttcacgg cgttcgccga ggatctgcct gggcaaggac       60

tcggcgtacc tgcaga                                                       76


<210>  169
<211>  77
<212>  DNA
<213>  Zea mays

<400>  169
tccgcaacgc gtcgccgttc aagttcacgg cgttcagccg aggatctgcc tgggcaagga       60

ctcggcgtac ctgcaga                                                      77


<210>  170
<211>  89
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  170
agggtaaatt tttaatttgg gatgttttac ttgaagattc tttagtgtag gaacatcaac       60

atgctcaatc tcaatcgtta gcacatcac                                         89


<210>  171
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Repair template

<400>  171
agggtaaatt tttaatttgg gatgttttac ttcaagaatc tttagtgtag gatcatcaaa       60

catgctcaat ctcaatcgtt agcacatcac                                        90


<210>  172
<211>  90
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  172
agggtaaatt tttaatttgg gatgttttac ttgaagattc tttagtgtag gatcatcaaa       60

catgctcaat ctcaatcgtt agcacatcac                                        90


<210>  173
<211>  90
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  173
agggtaaatt tttaatttgg gatgttttac ttgaagattc tttagtgtag gaacatcaaa       60

catgctcaat ctcaatcgtt agcacatcac                                        90


<210>  174
<211>  90
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  174
agggtaaatt tttaatttgg gatgttttac ttgaagattc tttagtgtag gatcatcaaa       60

catgctcaat ctcaatcgtt agcacatcac                                        90


<210>  175
<211>  90
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  175
agggtaaatt tttaatttgg gatgttttac ttgaagattc tttagtgtag gatcatcaaa       60

catgctcaat ctcaatcgtt agcacatcac                                        90


<210>  176
<211>  90
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  176
agggtaaatt tttaatttgg gatgttttac ttgaagattc tttagtgtag gaacatcaaa       60

catgctcaat ctcaatcgtt agcacatcac                                        90


<210>  177
<211>  57
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 3 crRNA


<220>
<221>  misc_feature
<222>  (38)..(57)
<223>  n is a, c, g, or u

<400>  177
guugcagaug uggagaaaua gagauaacga augcaacnnn nnnnnnnnnn nnnnnnn          57


<210>  178
<211>  57
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 5 crRNA


<220>
<221>  misc_feature
<222>  (38)..(57)
<223>  n is a, c, g, or u

<400>  178
guugcacagu gcuaauuaga gaaacuagga augcaacnnn nnnnnnnnnn nnnnnnn          57


<210>  179
<211>  57
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 6 crRNA


<220>
<221>  misc_feature
<222>  (38)..(57)
<223>  n is a, c, g, or u

<400>  179
guugcagaac ccgaauagac gaaugaagga augcaacnnn nnnnnnnnnn nnnnnnn          57


<210>  180
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 7 crRNA


<220>
<221>  misc_feature
<222>  (31)..(50)
<223>  n is a, c, g, or u

<400>  180
guuucugaag aaacuaugua ugaugugaag nnnnnnnnnn nnnnnnnnnn                  50


<210>  181
<211>  49
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 8 crRNA


<220>
<221>  misc_feature
<222>  (30)..(49)
<223>  n is a, c, g, or u

<400>  181
guuugcgagc uagcuugugg agugugaacn nnnnnnnnnn nnnnnnnnn                   49


<210>  182
<211>  52
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 9 crRNA


<220>
<221>  misc_feature
<222>  (33)..(52)
<223>  n is a, c, g, or u

<400>  182
guugcaacuu acgcauaggu guaaaauacg agnnnnnnnn nnnnnnnnnn nn               52


<210>  183
<211>  52
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 crRNA


<220>
<221>  misc_feature
<222>  (33)..(52)
<223>  n is a, c, g, or u

<400>  183
gucgcaucuu gcguaagcgc guggauugaa acnnnnnnnn nnnnnnnnnn nn               52


<210>  184
<211>  49
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 11 crRNA


<220>
<221>  misc_feature
<222>  (30)..(49)
<223>  n is a, c, g, or u

<400>  184
guuuuaguuu aacuauguga aauguaaaun nnnnnnnnnn nnnnnnnnn                   49


<210>  185
<211>  112
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  185
auuguauuau gcuccacuuu aauaaguggu gccuuccaaa gcuauaugcu gagggaggau       60

gggcgcuguu gcagcgucug cccaccucag aguggguauc cuuaccuauu uu              112


<210>  186
<211>  122
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  186
auuaugcucc acuuuaauaa guggugccuu ccaaagcuau augcugaggg aggaugggcg       60

cuguugcagc gucugcccac cucagagugg guauccuuac cuauuuugaa agguucugua      120

ag                                                                     122


<210>  187
<211>  107
<212>  RNA
<213>  Unknown

<220>
<223>  Candidatus Micrarchaeota archaeon

<400>  187
auuaugcucc acuuuaauaa guggugccuu ccaaagcuau augcugaggg aggaugggcg       60

cuguugcagc gucugcccac cucagagugg guauccuuac cuauuuu                    107


<210>  188
<211>  185
<212>  RNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  188
gaauguuauu ccauaauaac auuugaugca cacgauuccu cccuacagua guuagguaua       60

gccgaaaggu agagacuaaa ucuguaguug gagugggccg cuugcaucgg ccuaaaguug      120

agaaguguca gacucugaua acccucaacg acgauauucu uuauuucggu ucaaaguucu      180

gcaca                                                                  185


<210>  189
<211>  156
<212>  RNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  189
acacgauucc ucccuacagu aguuagguau agccgaaagg uagagacuaa aucuguaguu       60

ggagugggcc gcuugcaucg gccuaaaguu gagaaguguc agacucugau aacccucaac      120

gacgauauuc uuuauuucgg uucaaaguuc ugcaca                                156


<210>  190
<211>  131
<212>  RNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  190
acacgauucc ucccuacagu aguuagguau agccgaaagg uagagacuaa aucuguaguu       60

ggagugggcc gcuugcaucg gccuaaaguu gagaaguguc agacucugau aacccucaac      120

gacgauauuc u                                                           131


<210>  191
<211>  139
<212>  RNA
<213>  Unknown

<220>
<223>  Uncultured archaeon

<400>  191
acacgauucc ucccuacagu aguuagguau agccgaaagg uagagacuaa aucuguaguu       60

ggagugggcc gcuugcaucg gccuaaaguu gagaaguguc agacucugau aacccucaac      120

gacgauauuc uuuauuucg                                                   139


<210>  192
<211>  160
<212>  RNA
<213>  Parageobacillus thermoglucosidasius

<400>  192
aaaaucccuu ggggcgauuc agcguccuua agucgagaag ugccguaaua agcaucuaaa       60

aaugccuaac gguaacacuc gauaagguag uccugcuagg caggcugaaa cccuagccac      120

aaaauccggc uaggcaucau acagaaaauu guugucgaac                            160


<210>  193
<211>  140
<212>  RNA
<213>  Parageobacillus thermoglucosidasius

<400>  193
aucccuuggg gcgauucagc guccuuaagu cgagaagugc cguaauaagc aucuaaaaau       60

gccuaacggu aacacucgau aagguagucc ugcuaggcag gcugaaaccc uagccacaaa      120

auccggcuag gcaucauaca                                                  140


<210>  194
<211>  126
<212>  RNA
<213>  Acidibacillus sulfuroxidans

<400>  194
aaaucuuucc caaauacuuc uauucgucgg uucagcgacg auaagccgag aagugccaau       60

aaaacuguua agugguuugg uaacgcucgg uaagguagcc aaaaggcuga aacuccgugc      120

acaaag                                                                 126


<210>  195
<211>  113
<212>  RNA
<213>  Acidibacillus sulfuroxidans

<400>  195
auacuucuau ucgucgguuc agcgacgaua agccgagaag ugccaauaaa acuguuaagu       60

gguuugguaa cgcucgguaa gguagccaaa aggcugaaac uccgugcaca aag             113


<210>  196
<211>  86
<212>  RNA
<213>  Acidibacillus sulfuroxidans

<400>  196
auacuucuau ucgucgguuc agcgacgaua agccgagaag ugccaauaaa acuguuaagu       60

gguuugguaa cgcucgguaa gguagc                                            86


<210>  197
<211>  150
<212>  RNA
<213>  Ruminococcus sp.

<400>  197
aagguucaca caauuucagg gcgacucggc guccuaaaau cgagaaagug uacauaaguu       60

uuuaacaaaa uacgguaaau acucucggua agguuuuaac gugcacauaa uaauccgugc      120

aacaggguua cacuuuugug caauuuugca                                       150


<210>  198
<211>  129
<212>  RNA
<213>  Ruminococcus sp.

<400>  198
uuucagggcg acucggcguc cuaaaaucga gaaaguguac auaaguuuuu aacaaaauac       60

gguaaauacu cucgguaagg uuuuaacgug cacauaauaa uccgugcaac aggguuacac      120

uuuugugca                                                              129


<210>  199
<211>  129
<212>  RNA
<213>  Syntrophomonas palmitatica

<400>  199
uucgcgcgcc agggcaguua ggugcccuaa aagagcgaag uggccgaaag gaaaggcuaa       60

cgcuucucua acgcuacggc gaccuuggcg aaaugccauc aauaccacgc ggcccgaaag      120

gguucgcgc                                                              129


<210>  200
<211>  140
<212>  RNA
<213>  Syntrophomonas palmitatica

<400>  200
auuuacucug uuucgcgcgc cagggcaguu aggugcccua aaagagcgaa guggccgaaa       60

ggaaaggcua acgcuucucu aacgcuacgg cgaccuuggc gaaaugccau caauaccacg      120

cggcccgaaa ggguucgcgc                                                  140


<210>  201
<211>  153
<212>  RNA
<213>  Syntrophomonas palmitatica

<400>  201
auuuacucug uuucgcgcgc cagggcaguu aggugcccua aaagagcgaa guggccgaaa       60

ggaaaggcua acgcuucucu aacgcuacgg cgaccuuggc gaaaugccau caauaccacg      120

cggcccgaaa ggguucgcgc gaaacugagu aau                                   153


<210>  202
<211>  158
<212>  RNA
<213>  Syntrophomonas palmitatica

<400>  202
gcuuuaaagc cugacauaau uuacucuguu ucgcgcgcca gggcaguuag gugcccuaaa       60

agagcgaagu ggccgaaagg aaaggcuaac gcuucucuaa cgcuacggcg accuuggcga      120

aaugccauca auaccacgcg gcccgaaagg guucgcgc                              158


<210>  203
<211>  171
<212>  RNA
<213>  Syntrophomonas palmitatica

<400>  203
gcuuuaaagc cugacauaau uuacucuguu ucgcgcgcca gggcaguuag gugcccuaaa       60

agagcgaagu ggccgaaagg aaaggcuaac gcuucucuaa cgcuacggcg accuuggcga      120

aaugccauca auaccacgcg gcccgaaagg guucgcgcga aacugaguaa u               171


<210>  204
<211>  132
<212>  RNA
<213>  Clostridium novyi

<400>  204
uaaaacauag uuaaacuaau aaaaacaggg cgauuuaacg uccuaaggcu gagagaaguu       60

uuuucuacuc ggcaaggguu aaucucgauu guuguguuac cgaucgagcg uuucacaaaa      120

ugcgagagaa au                                                          132


<210>  205
<211>  116
<212>  RNA
<213>  Clostridium novyi

<400>  205
uaaaacauag uuaaacuaau aaaaacaggg cgauuuaacg uccuaaggcu gagagaaguu       60

uuuucuacuc ggcaaggguu aaucucgauu guuguguuac cgaucgagcg uuucac          116


<210>  206
<211>  108
<212>  RNA
<213>  Clostridium novyi

<400>  206
aguuaaacua auaaaaacag ggcgauuuaa cguccuaagg cugagagaag uuuuuucuac       60

ucggcaaggg uuaaucucga uuguuguguu accgaucgag cguuucac                   108


<210>  207
<211>  90
<212>  RNA
<213>  Clostridium novyi

<400>  207
agggcgauuu aacguccuaa ggcugagaga aguuuuuucu acucggcaag gguuaaucuc       60

gauuguugug uuaccgaucg agcguuucac                                        90


<210>  208
<211>  160
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 2 sgRNA version 5


<220>
<221>  misc_feature
<222>  (141)..(160)
<223>  n is a, c, g, or u

<400>  208
auuguauuau gcuccacuuu aauaaguggu gccuuccaaa gcuauaugcu gagggaggau       60

gggcgcuguu gcagcgucug cccaccucag aguggguauc cuuaccuauu uugaaaaagu      120

aauaggucaa ggaaugcaac nnnnnnnnnn nnnnnnnnnn                            160


<210>  209
<211>  183
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 2 sgRNA version 6


<220>
<221>  misc_feature
<222>  (164)..(183)
<223>  n is a, c, g, or u

<400>  209
auuaugcucc acuuuaauaa guggugccuu ccaaagcuau augcugaggg aggaugggcg       60

cuguugcagc gucugcccac cucagagugg guauccuuac cuauuuugaa agguucugua      120

aggaaaauug cagaacccaa aguaauaggu caaggaaugc aacnnnnnnn nnnnnnnnnn      180

nnn                                                                    183


<210>  210
<211>  155
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 2 sgRNA version 7


<220>
<221>  misc_feature
<222>  (136)..(155)
<223>  n is a, c, g, or u

<400>  210
auuaugcucc acuuuaauaa guggugccuu ccaaagcuau augcugaggg aggaugggcg       60

cuguugcagc gucugcccac cucagagugg guauccuuac cuauuuugaa aaaguaauag      120

gucaaggaau gcaacnnnnn nnnnnnnnnn nnnnn                                 155


<210>  211
<211>  246
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 6 sgRNA version 1


<220>
<221>  misc_feature
<222>  (227)..(246)
<223>  n is a, c, g, or u

<400>  211
gaauguuauu ccauaauaac auuugaugca cacgauuccu cccuacagua guuagguaua       60

gccgaaaggu agagacuaaa ucuguaguug gagugggccg cuugcaucgg ccuaaaguug      120

agaaguguca gacucugaua acccucaacg acgauauucu uuauuucggu ucaaaguucu      180

gcacagaaag uugcagaacc cgaauagacg aaugaaggaa ugcaacnnnn nnnnnnnnnn      240

nnnnnn                                                                 246


<210>  212
<211>  217
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 6 sgRNA version 2


<220>
<221>  misc_feature
<222>  (198)..(217)
<223>  n is a, c, g, or u

<400>  212
acacgauucc ucccuacagu aguuagguau agccgaaagg uagagacuaa aucuguaguu       60

ggagugggcc gcuugcaucg gccuaaaguu gagaaguguc agacucugau aacccucaac      120

gacgauauuc uuuauuucgg uucaaaguuc ugcacagaaa guugcagaac ccgaauagac      180

gaaugaagga augcaacnnn nnnnnnnnnn nnnnnnn                               217


<210>  213
<211>  181
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 6 sgRNA version 3


<220>
<221>  misc_feature
<222>  (162)..(181)
<223>  n is a, c, g, or u

<400>  213
acacgauucc ucccuacagu aguuagguau agccgaaagg uagagacuaa aucuguaguu       60

ggagugggcc gcuugcaucg gccuaaaguu gagaaguguc agacucugau aacccucaac      120

gacgauauuc ugaaacgaau agacgaauga aggaaugcaa cnnnnnnnnn nnnnnnnnnn      180

n                                                                      181


<210>  214
<211>  181
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 6 sgRNA version 4


<220>
<221>  misc_feature
<222>  (162)..(181)
<223>  n is a, c, g, or u

<400>  214
acacgauucc ucccuacagu aguuagguau agccgaaagg uagagacuaa aucuguaguu       60

ggagugggcc gcuugcaucg gccuaaaguu gagaaguguc agacucugau aacccucaac      120

gacgauauuc uuuauuucgg aaacgaauga aggaaugcaa cnnnnnnnnn nnnnnnnnnn      180

n                                                                      181


<210>  215
<211>  214
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 7 sgRNA version 1


<220>
<221>  misc_feature
<222>  (195)..(214)
<223>  n is a, c, g, or u

<400>  215
aaaaucccuu ggggcgauuc agcguccuua agucgagaag ugccguaaua agcaucuaaa       60

aaugccuaac gguaacacuc gauaagguag uccugcuagg caggcugaaa cccuagccac      120

aaaauccggc uaggcaucau acagaaaauu guugucgaac gaaaguuucu gaagaaacua      180

uguaugaugu gaagnnnnnn nnnnnnnnnn nnnn                                  214


<210>  216
<211>  194
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 7 sgRNA version 2


<220>
<221>  misc_feature
<222>  (175)..(194)
<223>  n is a, c, g, or u

<400>  216
aucccuuggg gcgauucagc guccuuaagu cgagaagugc cguaauaagc aucuaaaaau       60

gccuaacggu aacacucgau aagguagucc ugcuaggcag gcugaaaccc uagccacaaa      120

auccggcuag gcaucauaca gaaaguuucu gaagaaacua uguaugaugu gaagnnnnnn      180

nnnnnnnnnn nnnn                                                        194


<210>  217
<211>  178
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 7 sgRNA version 3


<220>
<221>  misc_feature
<222>  (159)..(178)
<223>  n is a, c, g, or u

<400>  217
aucccuuggg gcgauucagc guccuuaagu cgagaagugc cguaauaagc aucuaaaaau       60

gccuaacggu aacacucgau aagguagucc ugcuaggcag gcugaaaccc uagccacaaa      120

auccggcuag gcaucauaca gaaauguaug augugaagnn nnnnnnnnnn nnnnnnnn        178


<210>  218
<211>  179
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 8 sgRNA version 1


<220>
<221>  misc_feature
<222>  (160)..(179)
<223>  n is a, c, g, or u

<400>  218
aaaucuuucc caaauacuuc uauucgucgg uucagcgacg auaagccgag aagugccaau       60

aaaacuguua agugguuugg uaacgcucgg uaagguagcc aaaaggcuga aacuccgugc      120

acaaaggaaa guuugcgagc uagcuugugg agugugaacn nnnnnnnnnn nnnnnnnnn       179


<210>  219
<211>  166
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 8 sgRNA version 2


<220>
<221>  misc_feature
<222>  (147)..(166)
<223>  n is a, c, g, or u

<400>  219
auacuucuau ucgucgguuc agcgacgaua agccgagaag ugccaauaaa acuguuaagu       60

gguuugguaa cgcucgguaa gguagccaaa aggcugaaac uccgugcaca aaggaaaguu      120

ugcgagcuag cuuguggagu gugaacnnnn nnnnnnnnnn nnnnnn                     166


<210>  220
<211>  139
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 8 sgRNA version 3


<220>
<221>  misc_feature
<222>  (120)..(139)
<223>  n is a, c, g, or u

<400>  220
auacuucuau ucgucgguuc agcgacgaua agccgagaag ugccaauaaa acuguuaagu       60

gguuugguaa cgcucgguaa gguagcgaaa guuugcgagc uagcuugugg agugugaacn      120

nnnnnnnnnn nnnnnnnnn                                                   139


<210>  221
<211>  131
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 8 sgRNA version 4


<220>
<221>  misc_feature
<222>  (112)..(131)
<223>  n is a, c, g, or u

<400>  221
auacuucuau ucgucgguuc agcgacgaua agccgagaag ugccaauaaa acuguuaagu       60

gguuugguaa cgcucgguaa gguagcgaaa gcuagcuugu ggagugugaa cnnnnnnnnn      120

nnnnnnnnnn n                                                           131


<210>  222
<211>  206
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 9 sgRNA version 1


<220>
<221>  misc_feature
<222>  (187)..(206)
<223>  n is a, c, g, or u

<400>  222
aagguucaca caauuucagg gcgacucggc guccuaaaau cgagaaagug uacauaaguu       60

uuuaacaaaa uacgguaaau acucucggua agguuuuaac gugcacauaa uaauccgugc      120

aacaggguua cacuuuugug caauuuugca gaaaguugca acuuacgcau agguguaaaa      180

uacgagnnnn nnnnnnnnnn nnnnnn                                           206


<210>  223
<211>  185
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 9 sgRNA version 2


<220>
<221>  misc_feature
<222>  (166)..(185)
<223>  n is a, c, g, or u

<400>  223
uuucagggcg acucggcguc cuaaaaucga gaaaguguac auaaguuuuu aacaaaauac       60

gguaaauacu cucgguaagg uuuuaacgug cacauaauaa uccgugcaac aggguuacac      120

uuuugugcag aaaguugcaa cuuacgcaua gguguaaaau acgagnnnnn nnnnnnnnnn      180

nnnnn                                                                  185


<210>  224
<211>  176
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 9 sgRNA version 3


<220>
<221>  misc_feature
<222>  (157)..(176)
<223>  n is a, c, g, or u

<400>  224
uuucagggcg acucggcguc cuaaaaucga gaaaguguac auaaguuuuu aacaaaauac       60

gguaaauacu cucgguaagg uuuuaacgug cacauaauaa uccgugcaac aggguuacac      120

uuuugugcag aaauacgcau agguguaaaa uacgagnnnn nnnnnnnnnn nnnnnn          176


<210>  225
<211>  185
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 sgRNA version 1


<220>
<221>  misc_feature
<222>  (166)..(185)
<223>  n is a, c, g, or u

<400>  225
uucgcgcgcc agggcaguua ggugcccuaa aagagcgaag uggccgaaag gaaaggcuaa       60

cgcuucucua acgcuacggc gaccuuggcg aaaugccauc aauaccacgc ggcccgaaag      120

gguucgcgcg aaagucgcau cuugcguaag cgcguggauu gaaacnnnnn nnnnnnnnnn      180

nnnnn                                                                  185


<210>  226
<211>  196
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 sgRNA version 2


<220>
<221>  misc_feature
<222>  (177)..(196)
<223>  n is a, c, g, or u

<400>  226
auuuacucug uuucgcgcgc cagggcaguu aggugcccua aaagagcgaa guggccgaaa       60

ggaaaggcua acgcuucucu aacgcuacgg cgaccuuggc gaaaugccau caauaccacg      120

cggcccgaaa ggguucgcgc gaaagucgca ucuugcguaa gcgcguggau ugaaacnnnn      180

nnnnnnnnnn nnnnnn                                                      196


<210>  227
<211>  209
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 sgRNA version 3


<220>
<221>  misc_feature
<222>  (190)..(209)
<223>  n is a, c, g, or u

<400>  227
auuuacucug uuucgcgcgc cagggcaguu aggugcccua aaagagcgaa guggccgaaa       60

ggaaaggcua acgcuucucu aacgcuacgg cgaccuuggc gaaaugccau caauaccacg      120

cggcccgaaa ggguucgcgc gaaacugagu aaugaaaguc gcaucuugcg uaagcgcgug      180

gauugaaacn nnnnnnnnnn nnnnnnnnn                                        209


<210>  228
<211>  214
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 sgRNA version 4


<220>
<221>  misc_feature
<222>  (195)..(214)
<223>  n is a, c, g, or u

<400>  228
gcuuuaaagc cugacauaau uuacucuguu ucgcgcgcca gggcaguuag gugcccuaaa       60

agagcgaagu ggccgaaagg aaaggcuaac gcuucucuaa cgcuacggcg accuuggcga      120

aaugccauca auaccacgcg gcccgaaagg guucgcgcga aagucgcauc uugcguaagc      180

gcguggauug aaacnnnnnn nnnnnnnnnn nnnn                                  214


<210>  229
<211>  227
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 sgRNA version 5


<220>
<221>  misc_feature
<222>  (208)..(227)
<223>  n is a, c, g, or u

<400>  229
gcuuuaaagc cugacauaau uuacucuguu ucgcgcgcca gggcaguuag gugcccuaaa       60

agagcgaagu ggccgaaagg aaaggcuaac gcuucucuaa cgcuacggcg accuuggcga      120

aaugccauca auaccacgcg gcccgaaagg guucgcgcga aacugaguaa ugaaagucgc      180

aucuugcgua agcgcgugga uugaaacnnn nnnnnnnnnn nnnnnnn                    227


<210>  230
<211>  185
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 11 sgRNA version 1


<220>
<221>  misc_feature
<222>  (166)..(185)
<223>  n is a, c, g, or u

<400>  230
uaaaacauag uuaaacuaau aaaaacaggg cgauuuaacg uccuaaggcu gagagaaguu       60

uuuucuacuc ggcaaggguu aaucucgauu guuguguuac cgaucgagcg uuucacaaaa      120

ugcgagagaa augaaaguuu uaguuuaacu augugaaaug uaaaunnnnn nnnnnnnnnn      180

nnnnn                                                                  185


<210>  231
<211>  169
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 11 sgRNA version 2


<220>
<221>  misc_feature
<222>  (150)..(169)
<223>  n is a, c, g, or u

<400>  231
uaaaacauag uuaaacuaau aaaaacaggg cgauuuaacg uccuaaggcu gagagaaguu       60

uuuucuacuc ggcaaggguu aaucucgauu guuguguuac cgaucgagcg uuucacgaaa      120

guuuuaguuu aacuauguga aauguaaaun nnnnnnnnnn nnnnnnnnn                  169


<210>  232
<211>  161
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 11 sgRNA version 3


<220>
<221>  misc_feature
<222>  (142)..(161)
<223>  n is a, c, g, or u

<400>  232
aguuaaacua auaaaaacag ggcgauuuaa cguccuaagg cugagagaag uuuuuucuac       60

ucggcaaggg uuaaucucga uuguuguguu accgaucgag cguuucacga aaguuuuagu      120

uuaacuaugu gaaauguaaa unnnnnnnnn nnnnnnnnnn n                          161


<210>  233
<211>  145
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 11 sgRNA version 4


<220>
<221>  misc_feature
<222>  (126)..(145)
<223>  n is a, c, g, or u

<400>  233
aguuaaacua auaaaaacag ggcgauuuaa cguccuaagg cugagagaag uuuuuucuac       60

ucggcaaggg uuaaucucga uuguuguguu accgaucgag cguuucacga aagugaaaug      120

uaaaunnnnn nnnnnnnnnn nnnnn                                            145


<210>  234
<211>  127
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 11 sgRNA version 5


<220>
<221>  misc_feature
<222>  (108)..(127)
<223>  n is a, c, g, or u

<400>  234
agggcgauuu aacguccuaa ggcugagaga aguuuuuucu acucggcaag gguuaaucuc       60

gauuguugug uuaccgaucg agcguuucac gaaagugaaa uguaaaunnn nnnnnnnnnn      120

nnnnnnn                                                                127


<210>  235
<211>  1590
<212>  DNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 Zea mays codon optimized gene

<400>  235
atggccaaga acaccatcac caagaccctc aagctccgca tcgtccgccc ctacaacagc       60

gccgaggtcg agaagatcgt cgccgacgag aagaacaacc gcgagaagat cgccctggag      120

aagaacaagg acaaggtcaa ggaggcctgc agcaagcacc tcaaggtcgc cgcctactgc      180

accacccagg tcgagcgcaa cgcctgcctc ttctgcaagg cccgcaagct cgacgacaag      240

ttctaccaga agctccgcgg ccagttcccc gacgccgtgt tctggcagga gatcagcgag      300

atcttcaggc agctccagaa gcaggccgcc gagatctaca accagagcct catcgagctc      360

tactacgaga tcttcatcaa gggcaagggc atcgccaacg ccagcagcgt cgagcactac      420

ctcagcgacg tctgctacac cagggccgcc gagctcttca agaacgccgc catcgccagc      480

ggcctccgca gcaaaatcaa aagcaacttc cgcctcaagg agctcaagaa catgaaaagc      540

ggcctcccca cgaccaagag cgacaacttc cccatccccc tcgtcaagca gaagggcggc      600

cagtacaccg gcttcgagat cagcaaccac aacagcgact tcatcatcaa gatccccttc      660

ggccgctggc aggtcaagaa ggagatcgac aagtaccgcc cctgggagaa gttcgacttc      720

gagcaggtcc agaagagccc caagcctatc agcctcctcc tgtcgaccca gaggaggaag      780

cgcaataaag gctggagcaa ggacgagggc accgaggccg aaatcaaaaa ggtgatgaac      840

ggcgactacc agaccagcta catcgaggtc aagcgcggca gcaagatcgg cgagaagagc      900

gcctggatgc taaacctcag catcgacgtc cccaagatcg acaagggcgt cgaccccagc      960

atcatcggcg gcatcgacgt cggcgtcaag agccccctcg tctgcgcaat taacaacgcc     1020

ttcagccgct acagcatcag cgacaacgac ctcttccact tcaacaagaa gatgttcgcc     1080

cgccgccgca tcctcctcaa gaagaaccgc cataaacgcg ccggccacgg cgccaagaac     1140

aagctcaagc ccatcaccat cctcaccgag aagagcgaga ggttccgcaa gaagctcatc     1200

gagaggtggg cctgcgagat cgccgacttc ttcattaaaa acaaggtcgg caccgtccag     1260

atggagaacc tcgaaagcat gaaacgcaag gaggacagct acttcaacat caggctccgc     1320

ggcttctggc cctacgccga gatgcagaac aagatcgagt tcaagctcaa gcagtacggc     1380

atcgagatca ggaaggtcgc ccccaataat accagcaaga cctgcagcaa gtgcggccac     1440

ctcaacaact acttcaactt cgagtaccgc aagaagaaca agttccccca cttcaagtgc     1500

gagaagtgca acttcaagga gaacgccgac tacaacgccg ccctcaacat cagcaacccc     1560

aagctcaaga gcaccaagga ggagccctag                                      1590


<210>  236
<211>  1494
<212>  DNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 Zea mays codon optimized gene

<400>  236
atgggcgaga gcgtcaaggc aataaaatta aagatcctcg acatgttcct cgaccccgag       60

tgcaccaagc aggacgacaa ctggcgcaag gacctcagca ccatgagccg cttctgcgcc      120

gaggccggca acatgtgcct cagggacctc tacaactact tcagcatgcc caaggaggac      180

cgcatcagct ccaaggactt atataacgcc atgtaccata aaactaagct cctccacccc      240

gagctccccg ggaaggtggc taaccaaatc gtcaaccacg ccaaggacgt ctggaagcgc      300

aacgccaagc tcatctaccg caaccaaatc agcatgccca catataagat caccaccgcc      360

cccatccgcc tccaaaataa catctacaaa ttaataaaaa ataagaacaa atacataatc      420

gacgtccagc tctacagcaa ggagtacagc aaggacagcg gcaagggcac ccacaggtac      480

ttcctcgtcg ccgtcaggga cagcagcacc aggatgatct tcgacaggat catgagcaag      540

gaccacatcg acagcagcaa gagctacacc cagggccagc tccaaatcaa gaaggaccac      600

cagggcaagt ggtactgcat catcccctat acattcccca cccacgaaac cgtcctcgac      660

cccgacaagg tcatgggcgt cgacctcggg gtggctaagg ccgtctactg ggctttcaac      720

agcagctata aaagaggctg catcgacggc ggcgagatcg agcacttcag gaagatgatc      780

agggcccggc gcgtcagcat ccagaatcaa atcaaacaca gcggcgacgc ccgcaagggc      840

cacggcagga agagggccct caagcccatc gaaaccctca gcgagaagga gaagaacttc      900

cgcgacacaa taaaccacag gtacgccaac aggatcgtcg aggccgctat caagcagggc      960

tgcggcacca tccagatcga gaacctcgag ggcatcgctg acaccaccgg cagcaagttc     1020

ctcaagaact ggccctacta cgacctccag accaagatcg tcaataaagc caaggagcac     1080

ggcatcaccg tcgtcgcaat aaacccccag tatacatccc agcgctgcag catgtgcggc     1140

tacatcgaga aaaccaacag gagcagccag gccgtgttcg agtgcaagca gtgcggctac     1200

ggcagccgca ccatctgcat caactgcagg cacgtccaag tctccggcga cgtctgcgag     1260

gagtgcggcg gcatcgtcaa gaaggagaac gtcaacgccg actacaacgc cgccaagaac     1320

atcagcaccc cctacatcga ccagataata atggagaagt gcctcgagct cggcatcccc     1380

taccgctcca tcacctgcaa ggagtgcggc cacatccagg ctagcggcaa cacctgcgag     1440

gtctgcggca gcaccaacat cctcaaacca aagaagatcc gcaaggcaaa atag           1494


<210>  237
<211>  1494
<212>  DNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 Saccharomyces cerevisiae codon optimized gene

<400>  237
atgggagaat ccgtgaaggc catcaaactg aagatcctgg acatgttcct ggacccagag       60

tgtaccaaac aggacgacaa ctggagaaag gacctgagta ccatgtccag gttctgcgct      120

gaagccggca acatgtgttt gagggaccta tacaactact tctccatgcc aaaggaggac      180

cgtatctctt ccaaagacct atacaacgcc atgtaccaca aaaccaagct gctgcaccca      240

gaactgcccg gcaaagttgc aaaccaaatc gtcaaccacg ccaaggacgt ctggaaaagg      300

aacgccaagc tgatatacag gaaccagatc tccatgccaa catacaagat caccaccgcc      360

cccatcaggc tgcagaacaa catctacaag ctgatcaaga acaagaacaa gtacataatc      420

gacgtccagc tgtacagtaa ggagtactca aaggacagtg gcaaaggcac ccataggtac      480

ttcctggtcg cagtcagaga ctcatccacc aggatgatct tcgacaggat aatgtccaag      540

gatcacatcg acagttccaa gtcctacacc cagggacagc tgcagatcaa gaaggaccac      600

cagggcaagt ggtactgcat catcccctac accttcccaa ctcatgagac agtgttagac      660

cccgacaagg tgatgggagt ggacctgggc gtcgctaaag ccgtctactg ggccttcaac      720

agttcctaca agaggggctg catcgacgga ggcgaaatcg agcatttccg caagatgatc      780

agggccagga gggtcagtat ccagaaccag atcaaacaca gtggagacgc ccgtaagggc      840

cacggaagga agcgtgcttt gaagccaatc gagaccctgt ctgagaagga aaaaaacttc      900

agggacacca tcaaccacag gtacgccaac aggatcgtcg aagccgccat caagcagggc      960

tgcggaacca tccagatcga gaacctggaa ggaatcgctg ataccaccgg ctccaagttc     1020

ctgaagaact ggccatacta cgacctgcag accaagatcg tcaacaaggc caaggagcac     1080

ggaatcaccg tggttgccat caacccacaa tatacctccc agaggtgctc catgtgcggc     1140

tacatcgaga agacaaacag atcctcccag gctgtcttcg aatgcaagca gtgcggctac     1200

ggttccagga ccatctgcat caactgcaga cacgtccaag tttccggtga cgtctgcgaa     1260

gagtgcggcg gtatcgtcaa aaaggagaac gtgaacgcag actacaacgc cgccaagaat     1320

atcagtaccc cctacatcga ccagataatc atggagaaat gcctggagct aggcatcccc     1380

tacaggtcca tcacatgcaa ggagtgtggc cacatccaag ccagtggcaa tacctgcgaa     1440

gtctgcggca gtaccaatat cctgaaaccc aagaagatca ggaaggccaa gtaa           1494


<210>  238
<211>  202
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 sgRNA backbone

<400>  238
cuucacugau aaaguggaga accgcuucac caaaagcugu cccuuagggg auuagaacuu       60

gagugaaggu gggcugcuug caucagccua augucgagaa gugcuuucuu cggaaaguaa      120

cccucgaaac aaauucauuu uuccucucca auucugcaca agaaaguugc agaacccgaa      180

uagacgaaug aaggaaugca ac                                               202


<210>  239
<211>  165
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 sgRNA backbone

<400>  239
uucgcgcgcc agggcaguua ggugcccuaa aagagcgaag uggccgaaag gaaaggcuaa       60

cgcuucucua acgcuacggc gaccuuggcg aaaugccauc aauaccacgc ggcccgaaag      120

gguucgcgcg aaagucgcau cuugcguaag cgcguggauu gaaac                      165


<210>  240
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 Liguleless 2 sgRNA Target Sequence

<400>  240
cgauuuaugg augauaaacu                                                   20


<210>  241
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 Liguleless 3 sgRNA Target Sequence

<400>  241
uaguuuauca uccauaaauc                                                   20


<210>  242
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 nptII sgRNA Target Sequence

<400>  242
cuugcgcagc ugugcucgac                                                   20


<210>  243
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 ms26 sgRNA Target Sequence

<400>  243
aaguucacgg cguuccaggc                                                   20


<210>  244
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 ade2 sgRNA Target Sequence

<400>  244
uuuaguguag gaacaucaac                                                   20


<210>  245
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 VEGFA 2 sgRNA Target Sequence

<400>  245
ggggugaccg ccggagcgcg                                                   20


<210>  246
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 VEGFA 3 sgRNA Target Sequence

<400>  246
gccagagccg gggugugcag                                                   20


<210>  247
<211>  222
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 sgRNA Targeting Liguleless 2

<400>  247
cuucacugau aaaguggaga accgcuucac caaaagcugu cccuuagggg auuagaacuu       60

gagugaaggu gggcugcuug caucagccua augucgagaa gugcuuucuu cggaaaguaa      120

cccucgaaac aaauucauuu uuccucucca auucugcaca agaaaguugc agaacccgaa      180

uagacgaaug aaggaaugca accgauuuau ggaugauaaa cu                         222


<210>  248
<211>  222
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 sgRNA Targeting Liguleless 3

<400>  248
cuucacugau aaaguggaga accgcuucac caaaagcugu cccuuagggg auuagaacuu       60

gagugaaggu gggcugcuug caucagccua augucgagaa gugcuuucuu cggaaaguaa      120

cccucgaaac aaauucauuu uuccucucca auucugcaca agaaaguugc agaacccgaa      180

uagacgaaug aaggaaugca acuaguuuau cauccauaaa uc                         222


<210>  249
<211>  185
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 sgRNA Targeting nptII

<400>  249
uucgcgcgcc agggcaguua ggugcccuaa aagagcgaag uggccgaaag gaaaggcuaa       60

cgcuucucua acgcuacggc gaccuuggcg aaaugccauc aauaccacgc ggcccgaaag      120

gguucgcgcg aaagucgcau cuugcguaag cgcguggauu gaaaccuugc gcagcugugc      180

ucgac                                                                  185


<210>  250
<211>  185
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 sgRNA Targeting ms26

<400>  250
uucgcgcgcc agggcaguua ggugcccuaa aagagcgaag uggccgaaag gaaaggcuaa       60

cgcuucucua acgcuacggc gaccuuggcg aaaugccauc aauaccacgc ggcccgaaag      120

gguucgcgcg aaagucgcau cuugcguaag cgcguggauu gaaacaaguu cacggcguuc      180

caggc                                                                  185


<210>  251
<211>  185
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 10 sgRNA Targeting ade2

<400>  251
uucgcgcgcc agggcaguua ggugcccuaa aagagcgaag uggccgaaag gaaaggcuaa       60

cgcuucucua acgcuacggc gaccuuggcg aaaugccauc aauaccacgc ggcccgaaag      120

gguucgcgcg aaagucgcau cuugcguaag cgcguggauu gaaacuuuag uguaggaaca      180

ucaac                                                                  185


<210>  252
<211>  222
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 sgRNA Targeting VEGFA 2

<400>  252
cuucacugau aaaguggaga accgcuucac caaaagcugu cccuuagggg auuagaacuu       60

gagugaaggu gggcugcuug caucagccua augucgagaa gugcuuucuu cggaaaguaa      120

cccucgaaac aaauucauuu uuccucucca auucugcaca agaaaguugc agaacccgaa      180

uagacgaaug aaggaaugca acggggugac cgccggagcg cg                         222


<210>  253
<211>  222
<212>  RNA
<213>  Artificial

<220>
<223>  Cas-alpha 4 sgRNA Targeting VEGFA 3

<400>  253
cuucacugau aaaguggaga accgcuucac caaaagcugu cccuuagggg auuagaacuu       60

gagugaaggu gggcugcuug caucagccua augucgagaa gugcuuucuu cggaaaguaa      120

cccucgaaac aaauucauuu uuccucucca auucugcaca agaaaguugc agaacccgaa      180

uagacgaaug aaggaaugca acgccagagc cggggugugc ag                         222


<210>  254
<211>  461
<212>  PRT
<213>  Clostridioides difficile

<400>  254

Met Ile Ser Thr Arg Lys Ile Lys Val Arg Cys Asp Asp Ser Thr Phe 
1               5                   10                  15      


Tyr Thr Phe Phe Arg Gln Glu Gln Arg Glu Gln Asn Lys Ala Leu Asn 
            20                  25                  30          


Ile Gly Ile Gly Ile Ile His Ala Asn Ala Val Leu His Asn Val Asp 
        35                  40                  45              


Ser Gly Ala Glu Lys Lys Leu Lys Lys Ser Ile Glu Gly Leu Gln Gly 
    50                  55                  60                  


Lys Ile Asp Lys Leu Asn Lys Asp Leu Glu Lys Glu Lys Ile Thr Asp 
65                  70                  75                  80  


Lys Lys Lys Glu Glu Val Leu Lys Ala Ile Glu Thr Asn Lys Lys Ile 
                85                  90                  95      


Leu Asp Gly Glu Lys Lys Val Phe Lys Glu Ser Glu Glu Tyr Arg Lys 
            100                 105                 110         


Gly Ile Asp Glu Leu Phe Lys Asn Thr Tyr Leu Lys Ser Asn Thr Leu 
        115                 120                 125             


Asp His Val Leu Asp Ser Met Val Asn Ile Gln Tyr Lys Arg Thr Leu 
    130                 135                 140                 


Ser Leu Val Thr Gln Arg Ile Lys Lys Asp Tyr Ser Asn Asp Phe Val 
145                 150                 155                 160 


Gly Ile Ile Thr Gly Gln Gln Ser Leu Arg Asn Tyr Arg Asn Asp Asn 
                165                 170                 175     


Pro Leu Met Ile Ser Asn Gln Gln Leu Asn Phe Lys Tyr Ile Asp Asp 
            180                 185                 190         


Thr Phe Tyr Leu Asp Ile Met Cys Gly Tyr Arg Leu Glu Val Val Leu 
        195                 200                 205             


Gly Lys Arg Asp Asn Glu Asn Val Asn Glu Leu Lys Ser Thr Leu Glu 
    210                 215                 220                 


Lys Val Ile Ser Lys Glu Tyr Lys Val Cys Asp Ser Ser Met Gln Phe 
225                 230                 235                 240 


Ser Lys Asn Asn Lys Asp Val Ile Leu Asn Leu Val Ile Asp Ile Pro 
                245                 250                 255     


Gln Asn Ser Asn Val Tyr Lys Pro Val Glu Gly Arg Ile Leu Gly Val 
            260                 265                 270         


Asp Leu Gly Val Ala Val Pro Ile Tyr Met Cys Leu Asn Asp Asp Thr 
        275                 280                 285             


Tyr Lys Arg Lys Gly Leu Gly Asp Ile Asn Asn Phe Leu Arg Val Arg 
    290                 295                 300                 


Gln Gln Met Gln Thr Arg Arg Arg Lys Leu Gln Lys Asp Leu Thr Leu 
305                 310                 315                 320 


Thr Asn Gly Gly Lys Gly Arg Lys Lys Lys Thr Gln Leu Leu Asp Lys 
                325                 330                 335     


Leu Gln Glu Asn Glu Arg Asn Phe Val Lys Thr Tyr Ser His Ala Leu 
            340                 345                 350         


Ser Lys Arg Val Val Glu Phe Ala Lys Ser Asn Lys Cys Glu Tyr Ile 
        355                 360                 365             


Asn Ile Glu Lys Leu Thr Lys Asp Gly Phe Asp Asn Ile Ile Leu Arg 
    370                 375                 380                 


Asn Trp Ser Tyr Phe Glu Leu Gln Lys Met Ile Glu Tyr Lys Ala Glu 
385                 390                 395                 400 


Arg Glu Gly Ile Thr Val Arg Tyr Ala Asn Pro Ala Tyr Thr Ser Gln 
                405                 410                 415     


Lys Cys Ser Arg Cys Gly Glu Ile Asp Lys Glu Asn Arg Gln Thr Gln 
            420                 425                 430         


Ala Asn Phe Lys Cys Thr Lys Cys Gly Phe Glu Leu Asn Ala Asp His 
        435                 440                 445             


Asn Ala Ala Ile Asn Ile Ala Arg Ser Ile Glu Phe Val 
    450                 455                 460     


<210>  255
<211>  448
<212>  PRT
<213>  Clostridium paraputrificum

<400>  255

Met Asn Phe Asn Lys Cys Ile Lys Val Thr Leu Ile Lys Cys Leu Asn 
1               5                   10                  15      


Tyr Asp Tyr Arg Lys Val Lys Gln Ile Ile Lys Asp Phe Gln Tyr Lys 
            20                  25                  30          


Tyr Ser Lys Ala Tyr Asn Met Ala Thr Asn Tyr Leu Tyr Leu Trp Asp 
        35                  40                  45              


Thr Asn Ser Met Asn Leu Lys Asn Leu Tyr Asp Thr Lys Ile Val Asp 
    50                  55                  60                  


Lys Glu Leu Leu Gly Lys Ser Lys Gly Ala Trp Ile Glu Asn Arg Met 
65                  70                  75                  80  


Asn Glu Ile Ile Glu Gly Ala Leu Ser Asn Asn Val Ala Gln Ala Arg 
                85                  90                  95      


Gln Asp Ile Ile Asn Lys Tyr Asn Lys Cys Lys Lys Asp Gly Leu Phe 
            100                 105                 110         


Lys Gly Lys Val Ser Leu Pro Thr Tyr Lys Leu Asp Ser Lys Val Ile 
        115                 120                 125             


Val His Asn Val Ala Tyr Lys Leu Arg Asn His Asn Gly Tyr Phe Ile 
    130                 135                 140                 


Asp Ile Gly Leu Leu Asn Lys Gly Lys Gln Lys Glu Leu Asn Val Gly 
145                 150                 155                 160 


Arg Phe Glu Phe Gln Ile Asp Lys Leu Asp Gly Asn Lys Lys Ala Thr 
                165                 170                 175     


Ile Asn Lys Ile Ile Asn Gly Glu Tyr Lys Gln Gly Ser Ala Gln Ile 
            180                 185                 190         


Ser Ile Ser Lys Lys Gly Lys Ile Glu Leu Ile Ile Ser Tyr Ser Phe 
        195                 200                 205             


Asp Lys Glu Glu Ile Pro Val Leu Asp Asn Asn Arg Ile Leu Gly Ile 
    210                 215                 220                 


Asp Leu Gly Ile Thr Asn Val Ala Thr Met Ser Val Tyr Asp Ser Ile 
225                 230                 235                 240 


Lys Asp Glu Tyr Asp Tyr Phe Ser Trp Lys Thr Asn Val Ile Arg Gly 
                245                 250                 255     


Lys Glu Leu Ile Ala Phe Arg Gln Lys Tyr Tyr Asn Leu Arg Arg Asp 
            260                 265                 270         


Ile Ser Ile Ala Ser Lys Thr Ala Gly Lys Gly Arg Cys Gly His Gly 
        275                 280                 285             


Tyr Lys Thr Lys Met Lys Pro Val Asp Lys Val Arg Asn Arg Ile Ala 
    290                 295                 300                 


Asn Phe Ala Asp Thr Tyr Asn His Lys Ile Ser Lys Tyr Ile Val Glu 
305                 310                 315                 320 


Phe Ala Val Lys Asn Arg Cys Gly Ile Ile Gln Met Glu Asp Leu Ser 
                325                 330                 335     


Gly Ala Thr Ser Glu Val His Asn Lys Met Leu Lys Asp Trp Ser Tyr 
            340                 345                 350         


Tyr Asp Leu Gln Gln Lys Ile Glu Tyr Lys Ala Lys Glu Gln Gly Ile 
        355                 360                 365             


Glu Ile Lys Lys Val Asn Pro Lys Tyr Thr Ser Lys Arg Cys Asn Asn 
    370                 375                 380                 


Cys Gly Cys Ile His Glu Asp Asn Arg Asp Cys Lys Asn His Gln Ala 
385                 390                 395                 400 


Arg Phe Glu Cys Lys Val Cys Gly His Gly Lys Asp Thr Asp Val Asn 
                405                 410                 415     


Ala Asp Val Asn Ala Ser Arg Asn Ile Ala Ile Pro Asp Ile Asp Lys 
            420                 425                 430         


Ile Ile Glu Glu Thr Glu Ile Leu His Ser Glu Asn Lys Pro Ala Ser 
        435                 440                 445             


<210>  256
<211>  430
<212>  PRT
<213>  Clostridium novyi

<400>  256

Met Asn Lys Cys Ile Lys Val Ala Ile Lys Asn Cys Lys Glu Leu Asp 
1               5                   10                  15      


Tyr Lys Val Met Ser Glu Lys Leu Arg Asn Ile Gln Tyr Leu Thr Cys 
            20                  25                  30          


Lys Ala Ser Asn Lys Val Met Gln Met Tyr Tyr Met Trp Glu Asn Gln 
        35                  40                  45              


Lys Ile Asp Ile Lys Asn Lys Thr Gly Glu Tyr Pro Asp Asp Lys Glu 
    50                  55                  60                  


Leu Phe Gly Lys Thr Tyr Arg Asn Val Val Glu Gly Glu Met Lys Thr 
65                  70                  75                  80  


Ile Met Asn Thr Ile Asn Thr Ser Asn Val Gly Gln Thr Asn Ala Ile 
                85                  90                  95      


Ile Met Lys Lys Trp Asn Thr Asp Lys Lys Glu Val Leu Ser Tyr Gln 
            100                 105                 110         


Lys Ser Leu Pro Asn Phe Lys Leu Asn Met Pro Ile Tyr Ile Lys Asn 
        115                 120                 125             


Lys Ser Phe Ser Ile Val Lys Gly Thr Ser Gly Tyr Glu Ile Ile Cys 
    130                 135                 140                 


Ser Ile Phe Asn Lys Ser Gln Asp Leu Lys Arg Leu Thr Phe Ile Ile 
145                 150                 155                 160 


Asp Lys Leu Asp Gly Asn Lys Lys Ala Thr Leu Asn Lys Ile Ile Asp 
                165                 170                 175     


Leu Thr Tyr Lys Gln Gly Ala Gly Gln Ile Ile Lys Asp Arg Lys Gly 
            180                 185                 190         


Lys Trp Tyr Phe Ile Ile Ser Phe Gly Phe Glu Asn Lys Lys Arg Glu 
        195                 200                 205             


Leu Asp Ile Asn Arg Ile Leu Gly Ile Asp Val Gly Ile Thr Asn Leu 
    210                 215                 220                 


Leu Thr Met Gln Ile Trp Asp Cys Asn Leu Lys Glu Trp Asp Arg Leu 
225                 230                 235                 240 


Ala Trp Asn Ser Cys Met Val Asp Gly Arg Glu Leu Met His Tyr Arg 
                245                 250                 255     


Gln Lys Ile Glu Ala Arg Arg Lys Ser Leu Leu Lys Asn Ser Lys Ile 
            260                 265                 270         


Ser Glu Lys Asn Thr Gly Lys Ala Gly His Gly Ile Ser Lys Arg Ile 
        275                 280                 285             


Gln Ala Ile Asp Val Val Arg Asn Lys Glu Lys Asn Phe Arg Asp Thr 
    290                 295                 300                 


Phe Asn His Lys Tyr Ser Arg Tyr Ala Val Asp Phe Ala Ile Arg Asn 
305                 310                 315                 320 


Asn Cys Gly Ile Ile Gln Met Glu Asn Leu Ala Lys Phe Thr Glu Glu 
                325                 330                 335     


Val Lys Glu Lys Met Leu Lys Asn Trp Ser Tyr Tyr Asp Leu Gln Ser 
            340                 345                 350         


Lys Ile Lys Tyr Lys Ala Glu Glu Gln Gly Ile Lys Val Asn Phe Ile 
        355                 360                 365             


Lys Pro Ser Tyr Thr Ser Lys Arg Cys Ser Leu Cys Gly Ala Ile Asp 
    370                 375                 380                 


Asp Arg Asn Arg Asp Cys Lys Asn Asn Gln Ser Lys Phe Gln Cys Val 
385                 390                 395                 400 


Val Cys Asp His Lys Glu His Ala Asp Ile Asn Ala Ala Lys Asn Ile 
                405                 410                 415     


Ala Leu Pro Asp Ile Glu Glu Leu Ile Glu Ser Lys Ile Gly 
            420                 425                 430 


<210>  257
<211>  436
<212>  PRT
<213>  Ruminococcus albus

<400>  257

Met Asn Lys Val Val Arg Leu Ala Leu Ile Cys Glu His Phe Asp Lys 
1               5                   10                  15      


Asp Gly Asn Pro Val Asp Tyr Ser Asp Val Tyr Lys Leu Leu Trp Gln 
            20                  25                  30          


Leu Gln Ala Gln Thr Arg Glu Ile Lys Asn Lys Thr Ile Gln Tyr Cys 
        35                  40                  45              


Trp Glu Tyr Ser Asn Phe Ser Ser Asp Tyr Tyr Lys Glu Asn His Glu 
    50                  55                  60                  


Tyr Pro Lys Glu Lys Asp Val Leu Asn Tyr Thr Leu Gly Gly Phe Val 
65                  70                  75                  80  


Asn Asp Lys Phe Lys Val Gly Asn Asp Leu Tyr Ser Ala Asn Cys Ser 
                85                  90                  95      


Thr Thr Thr Gln Thr Val Cys Ala Glu Phe Lys Asn Ser Lys Ser Glu 
            100                 105                 110         


Phe Leu Lys Gly Thr Lys Ser Ile Ile Asn Tyr Lys Ser Asn Gln Pro 
        115                 120                 125             


Leu Asp Leu His Asn Lys Ser Ile Arg Val Glu Tyr Lys Asp Asn Asp 
    130                 135                 140                 


Phe Phe Val Phe Leu Lys Leu Leu Asn Arg His Ala Phe Lys Arg Leu 
145                 150                 155                 160 


Gly Tyr Lys Asn Thr Glu Ile Cys Phe Lys Val Ile Val Arg Asp Lys 
                165                 170                 175     


Ser Thr Arg Thr Ile Leu Glu Arg Cys Val Asp Gln Ile Tyr Gly Ile 
            180                 185                 190         


Ser Ala Ser Lys Leu Ile Tyr Asn Lys Lys Lys Lys Gln Trp Phe Leu 
        195                 200                 205             


Asn Leu Val Tyr Ala Phe Glu Pro Asp Asn Ala Asn Asn Leu Asp Pro 
    210                 215                 220                 


Asn Arg Ile Leu Gly Val Asp Leu Gly Ile His Tyr Pro Ile Cys Ala 
225                 230                 235                 240 


Ser Val Tyr Gly Asp Leu Gln Arg Phe Thr Ile His Gly Gly Glu Ile 
                245                 250                 255     


Glu Glu Phe Arg Arg Arg Val Glu Ser Arg Lys Leu Ser Leu Leu Lys 
            260                 265                 270         


Gln Gly Lys Asn Cys Gly Asp Gly Arg Ile Gly His Gly Val Lys Thr 
        275                 280                 285             


Arg Asn Lys Pro Val Tyr Ser Ile Glu Asp Arg Ile Ala Arg Phe Arg 
    290                 295                 300                 


Asp Thr Val Asn His Lys Tyr Ser Arg Ala Leu Ile Asp Tyr Ala Val 
305                 310                 315                 320 


Lys Lys Glu Cys Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Thr 
                325                 330                 335     


Ala Glu Ser Asp Arg Phe Leu Lys Asn Trp Ser Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Thr Lys Ile Glu Tyr Lys Ala Lys Glu Lys Gly Ile Lys Ile Val Tyr 
        355                 360                 365             


Ile Asp Pro Lys Tyr Ser Ser Gln Arg Cys Ser Lys Cys Gly His Ile 
    370                 375                 380                 


Asp Lys Glu Asn Arg Lys Thr Gln Ser Ser Phe Val Cys Leu Lys Cys 
385                 390                 395                 400 


Gly Phe Glu Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Gly Ile 
                405                 410                 415     


Lys Asp Ile Asp Lys Ile Ile Glu Ser Asp Leu Ser Ser Lys Cys Glu 
            420                 425                 430         


Thr Asp Val Asn 
        435     


<210>  258
<211>  402
<212>  PRT
<213>  Clostridium hiranonis

<400>  258

Met Ile Thr Val Arg Lys Leu Lys Leu Thr Ile Ile Asn Asp Asp Glu 
1               5                   10                  15      


Thr Lys Arg Asn Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln Tyr Ala 
            20                  25                  30          


Gln Tyr Gln Gly Leu Asn Leu Ala Met Ser Val Leu Thr Asn Ala Tyr 
        35                  40                  45              


Leu Ser Ser Asn Arg Asp Ile Lys Ser Asp Leu Phe Lys Glu Thr Gln 
    50                  55                  60                  


Lys Asn Leu Lys Asn Ser Ser His Ile Phe Asp Asp Ile Thr Phe Gly 
65                  70                  75                  80  


Lys Gly Thr Asp Asn Lys Ser Leu Ile Asn Gln Lys Val Lys Lys Asp 
                85                  90                  95      


Phe Asn Ser Ala Ile Lys Asn Gly Leu Ala Arg Gly Glu Arg Asn Ile 
            100                 105                 110         


Thr Asn Tyr Lys Arg Thr Phe Pro Leu Met Thr Arg Gly Thr Ala Leu 
        115                 120                 125             


Lys Phe Ser Tyr Lys Asp Asp Cys Ser Asp Glu Ile Ile Ile Lys Trp 
    130                 135                 140                 


Val Asn Lys Ile Val Phe Lys Val Val Ile Gly Arg Lys Asp Lys Asn 
145                 150                 155                 160 


Tyr Leu Glu Leu Met His Thr Leu Asn Lys Val Ile Asn Gly Glu Tyr 
                165                 170                 175     


Lys Val Gly Gln Ser Ser Ile Tyr Phe Asp Lys Ser Asn Lys Leu Ile 
            180                 185                 190         


Leu Asn Leu Thr Leu Tyr Ile Pro Glu Lys Lys Asp Asp Asp Ala Ile 
        195                 200                 205             


Asn Gly Arg Thr Leu Gly Val Asp Leu Gly Ile Lys Tyr Pro Ala Tyr 
    210                 215                 220                 


Val Cys Leu Asn Asp Asp Thr Phe Ile Arg Gln His Ile Gly Glu Ser 
225                 230                 235                 240 


Leu Glu Leu Ser Lys Gln Arg Glu Gln Phe Arg Asn Arg Arg Lys Arg 
                245                 250                 255     


Leu Gln Gln Gln Leu Lys Asn Val Lys Gly Gly Lys Gly Arg Glu Lys 
            260                 265                 270         


Lys Leu Ala Ala Leu Asp Lys Val Ala Val Cys Glu Arg Asn Phe Val 
        275                 280                 285             


Lys Thr Tyr Asn His Thr Ile Ser Lys Arg Ile Ile Asp Phe Ala Lys 
    290                 295                 300                 


Lys Asn Lys Cys Glu Phe Ile Asn Leu Glu Gln Leu Thr Lys Asp Gly 
305                 310                 315                 320 


Phe Asp Asn Ile Ile Leu Ser Asn Trp Ser Tyr Tyr Glu Leu Gln Asn 
                325                 330                 335     


Met Ile Lys Tyr Lys Ala Asp Arg Glu Gly Ile Lys Val Arg Tyr Val 
            340                 345                 350         


Asn Pro Ala Tyr Thr Ser Gln Lys Cys Ser Lys Cys Gly Tyr Ile Asp 
        355                 360                 365             


Lys Glu Asn Arg Pro Thr Gln Glu Lys Phe Lys Cys Ile Lys Cys Gly 
    370                 375                 380                 


Phe Glu Leu Asn Ala Asp His Asn Ala Ala Ile Asn Ile Ser Arg Leu 
385                 390                 395                 400 


Glu Glu 
        


<210>  259
<211>  493
<212>  PRT
<213>  Clostridium ihumii

<400>  259

Met Lys Thr Thr Glu Lys Asn Val Leu Met Thr Lys Cys Ile Lys Val 
1               5                   10                  15      


Thr Leu Asn Arg Cys Val Asn Tyr Asn Met Lys Glu Ile Met Asn Ile 
            20                  25                  30          


Ile Arg Glu Met Gln Tyr Leu Ser Ser Lys Ala Tyr Asn Leu Ala Thr 
        35                  40                  45              


Asn Tyr Leu Tyr Ile Trp Asp Thr Asn Ser Met Asn Phe Lys Asn Leu 
    50                  55                  60                  


Tyr Glu Glu Lys Ile Val Asp Lys Asp Leu Leu Gly Lys Ser Lys Ser 
65                  70                  75                  80  


Ala Trp Ile Glu Asn Arg Met Asn Glu Ile Met Lys Gly Phe Leu Thr 
                85                  90                  95      


Asn Asn Val Ala Gln Ala Arg Gln Asp Val Ile Asn Lys Tyr Asn Lys 
            100                 105                 110         


Ser Lys Lys Asp Gly Leu Phe Ile Gly Lys Val Thr Leu Pro Ser Tyr 
        115                 120                 125             


Lys Met Asn Gly Lys Val Val Ile His Asn Lys Ala Tyr Arg Phe Ser 
    130                 135                 140                 


Lys Asn Glu Gly Tyr Phe Val Glu Ile Gly Leu Phe Asn Lys Glu Lys 
145                 150                 155                 160 


Lys Glu Glu Leu Asn Cys Asp Trp Ile Lys Phe Lys Leu Asp Lys Ile 
                165                 170                 175     


Asp Ser Asn Lys Lys Ala Thr Ile Tyr Lys Ile Leu Asn Gly Asp Tyr 
            180                 185                 190         


Lys Gln Gly Ser Ala Gln Leu His Ile Asn Lys Lys Gly Lys Ile Glu 
        195                 200                 205             


Phe Ile Ile Ser Tyr Ser Phe Glu Arg Glu Asn Ser Ile Lys Leu Asp 
    210                 215                 220                 


Lys Asn Arg Thr Leu Gly Ile Asp Ile Gly Ile Val Asn Ile Ala Ala 
225                 230                 235                 240 


Met Ala Ile Trp Asp Asn Asn Lys Gln Glu Trp Glu Leu Thr Arg Tyr 
                245                 250                 255     


Ser His Asn Leu Ile Ser Gly Asn Glu Ala Ile Ala Leu Arg Gln Lys 
            260                 265                 270         


Tyr Tyr Lys Leu Gly Leu Arg Asn Lys Glu Leu Glu Lys Asn Ile Asn 
        275                 280                 285             


Arg Glu Leu His Glu Leu Glu Glu Lys Glu Tyr Arg Gly Leu Ser Thr 
    290                 295                 300                 


Asn Ile Ile Ser Gly His Asn Leu Thr Tyr Lys Arg Ile Met Leu Asn 
305                 310                 315                 320 


Ser Lys Arg Ile Arg Leu Ser Gln Ser Cys Lys Trp Cys Gly Asn Ser 
                325                 330                 335     


Lys Val Gly His Gly Arg Arg Val Arg Cys Lys Gln Val Asp Lys Ile 
            340                 345                 350         


Gly Asn Lys Ile Glu Arg Phe Lys Asp Thr Phe Asn His Lys Tyr Ser 
        355                 360                 365             


Arg Tyr Ile Val Asp Phe Ala Val Lys Asn Asn Cys Gly Ile Ile Gln 
    370                 375                 380                 


Met Glu Asn Leu Lys Asn Phe Asn Pro Ser Glu Lys Phe Leu Lys Asp 
385                 390                 395                 400 


Trp Pro Tyr Phe Asp Leu Gln Thr Lys Ile Glu Tyr Lys Ala Lys Glu 
                405                 410                 415     


Tyr Gly Ile Glu Val Ile Lys Val Asn Pro Lys Tyr Thr Ser Lys Arg 
            420                 425                 430         


Cys Ser Arg Cys Gly Cys Ile Asn Glu Leu Asn Arg Asp Cys Lys Lys 
        435                 440                 445             


Asn Gln Ser Lys Phe Lys Cys Val Asn Asp Glu Cys Asn Asn Tyr Glu 
    450                 455                 460                 


Asn Ala Asp Ile Asn Ala Ala Lys Asn Ile Ala Leu Pro Tyr Ile Asp 
465                 470                 475                 480 


Lys Ile Ile Glu Gln Cys Leu Glu Thr Asn Lys Val Val 
                485                 490             


<210>  260
<211>  398
<212>  PRT
<213>  Cellulosilyticum ruminicola

<400>  260

Met Ile Ala Val Arg Lys Leu Lys Ile Met Val Leu Cys Asp Asp Glu 
1               5                   10                  15      


Ser Lys Lys Asn Glu Gln Tyr Lys Phe Leu Arg Asp Ser Gln Tyr Ala 
            20                  25                  30          


Gln Tyr Leu Gly Leu Asn Arg Ala Met Ser Phe Leu Ala Lys Glu Tyr 
        35                  40                  45              


Leu Ser Gly Asp Lys Glu Arg Phe Lys Glu Ala Lys Lys Lys Leu Thr 
    50                  55                  60                  


Asn Thr Cys Glu Cys Tyr Gln Asn Ile Asn Phe Gly Thr Gly Ile Asp 
65                  70                  75                  80  


Ser Lys Ser Gln Ile Thr Gln Lys Val Lys Lys Asp Leu Gln Ala Asp 
                85                  90                  95      


Ile Lys Asn Gly Leu Ala Arg Gly Glu Arg Ser Ile Arg Asn Tyr Arg 
            100                 105                 110         


Arg Thr Phe Pro Leu Ile Thr Arg Gly Arg Asp Leu Lys Phe Ser Tyr 
        115                 120                 125             


Asn Gly Asp Glu Ile Ile Ile Lys Trp Val Asn Lys Ile Tyr Phe Lys 
    130                 135                 140                 


Val Leu Ile Gly Arg Lys Asp Lys Asn Tyr Leu Glu Leu Met His Thr 
145                 150                 155                 160 


Leu Glu Lys Ile Ile Asn Gly Glu Tyr Lys Val Cys Thr Ser Ser Ile 
                165                 170                 175     


Gln Ile Asp Lys Lys Leu Ile Leu Asn Leu Thr Leu Glu Ile Pro Asp 
            180                 185                 190         


Lys Val Lys Lys Glu Phe Gln Glu Asn Arg Val Leu Gly Val Asp Leu 
        195                 200                 205             


Gly Ile Lys Phe Pro Ala Tyr Ala Cys Val Ser Asp Asn Thr Tyr Val 
    210                 215                 220                 


Arg Arg Ser Phe Gly Ser Ile Asp Glu Phe Leu Lys Val Arg Ile Gln 
225                 230                 235                 240 


Phe Asp Lys Arg Arg Lys Arg Ile Gln Gln Gln Leu Gln Asn Val Lys 
                245                 250                 255     


Gly Gly Lys Gly Arg Lys Asp Lys Leu Gln Ala Leu Asp Arg Met Arg 
            260                 265                 270         


Asp Cys Glu Arg Lys Trp Val Arg Asn Tyr Asn His Ala Leu Ser Lys 
        275                 280                 285             


Arg Ile Ile Asp Phe Ala Phe Arg Asn Lys Cys Gly Ile Ile His Leu 
    290                 295                 300                 


Glu Lys Leu Glu Lys Asp Gly Phe Lys Asn Lys Leu Leu Arg Asn Trp 
305                 310                 315                 320 


Ser Tyr Tyr Glu Leu Gln Asp Met Ile Gly Tyr Lys Ala Glu Arg Glu 
                325                 330                 335     


Gly Ile Val Val Lys Tyr Val Glu Pro Ala Tyr Thr Ser Gln Thr Cys 
            340                 345                 350         


Ser Lys Cys Gly Tyr Val Asp Arg Glu Asn Arg Pro Ser Gln Glu His 
        355                 360                 365             


Phe Leu Cys Lys Glu Cys Gly Phe Glu Ile Asn Ala Asp His Asn Ala 
    370                 375                 380                 


Ala Ile Asn Ile Ala Arg Ser Asn Lys Val Ile Val Asp Lys 
385                 390                 395             


<210>  261
<211>  433
<212>  PRT
<213>  Eubacterium siraeum

<400>  261

Met Val Cys Asn Lys Val Ile Lys Ile Ala Leu Ile Cys Asp Gln Ile 
1               5                   10                  15      


Asp Lys Asp Gly Lys Asp Val Asn Tyr Asn Asp Ile Tyr Lys Leu Leu 
            20                  25                  30          


Trp Asp Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Val Ile Arg 
        35                  40                  45              


Leu Cys Trp Glu Trp Ser Gly Tyr Ser Ser Glu Tyr Phe Lys Thr His 
    50                  55                  60                  


Glu Glu Tyr Pro Lys Asp Lys Glu Ile Phe Gly Ile Ser Leu Arg Gly 
65                  70                  75                  80  


Tyr Leu Tyr Asp Arg Ile Lys Gly Asp Tyr Asn Leu Tyr Ser Gly Asn 
                85                  90                  95      


Leu Ser Gln Ser Ala Glu Ile Ala Tyr Lys Glu Tyr Lys Asn Ser Leu 
            100                 105                 110         


Lys Asp Val Leu Arg Gly Asp Lys Ser Ile Ile Asn Tyr Arg Glu Asn 
        115                 120                 125             


Gln Pro Leu Asp Ile Lys Asn Lys Ala Ile Gln Leu Leu Tyr Glu Asn 
    130                 135                 140                 


Asp Asn Phe Phe Val Arg Val Ala Leu Ile Asn Lys Asp Lys Gln Lys 
145                 150                 155                 160 


Glu Leu Asn Phe Lys Asp Cys Ser Val Arg Phe Lys Leu Leu Val Lys 
                165                 170                 175     


Asp Asp Ser Thr Arg Thr Ile Leu Glu Arg Cys Phe Asp Glu Val Tyr 
            180                 185                 190         


Thr Ile Thr Ala Ser Lys Ile Met Tyr Asn Lys Lys Lys Lys Gln Trp 
        195                 200                 205             


Tyr Ile Asn Leu Gly Tyr Lys Phe Thr Lys Glu Ile Asp Lys Thr Leu 
    210                 215                 220                 


Asp Lys Asp Arg Ile Leu Gly Val Asp Leu Gly Val Ile Asn Pro Leu 
225                 230                 235                 240 


Val Ala Ser Val Tyr Gly Ser Tyr Asp Arg Leu Ile Ile Gly Gly Gly 
                245                 250                 255     


Glu Ile Asp Lys Phe Arg Lys Arg Val Glu Ala Asn Lys Val Gln Met 
            260                 265                 270         


Leu Lys Gln Gly Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Val 
        275                 280                 285             


Asn Thr Arg Asn Lys Pro Ala Tyr Asn Ile Glu Asp Lys Ile Ser Arg 
    290                 295                 300                 


Phe Arg Asp Thr Val Asn His Lys Tyr Ser Lys Ala Val Val Asp Tyr 
305                 310                 315                 320 


Ala Val Lys Asn Asn Cys Gly Thr Ile Gln Met Glu Asp Leu Lys Gly 
                325                 330                 335     


Ile Thr Gln Asn Lys Asn Glu Arg Tyr Leu Lys Asn Trp Thr Tyr Phe 
            340                 345                 350         


Asp Leu Gln Thr Lys Ile Glu Tyr Lys Ala Lys Ala Leu Gly Ile Glu 
        355                 360                 365             


Val Lys Tyr Lys Asn Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys 
    370                 375                 380                 


Gly His Ile Ala Glu Glu Asn Arg Pro Glu Gln Lys Thr Phe Lys Cys 
385                 390                 395                 400 


Val Lys Cys Gly Phe Lys Val Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
                405                 410                 415     


Leu Ala Ile Lys Asp Ile Asp Lys Ile Ile Glu Gln Tyr Tyr Asn Lys 
            420                 425                 430         


Gly 
    


<210>  262
<211>  482
<212>  PRT
<213>  Clostridium botulinum

<400>  262

Met Asn Thr Val Arg Lys Ile Lys Leu Thr Ile Leu Gly Asp Thr Glu 
1               5                   10                  15      


Thr Arg Asn Lys Gln Tyr Lys Trp Ile Arg Asp Glu Gln Tyr Asn Gln 
            20                  25                  30          


Tyr Arg Ala Leu Asn Leu Ser Met Thr Tyr Met Val Thr Asn Leu Met 
        35                  40                  45              


Leu Lys Asn Asn Glu Ser Gly Leu Glu Asn Arg Lys Glu Lys Asp Ile 
    50                  55                  60                  


Leu Lys Ile Glu Asn Lys Ile Lys Lys Asp Glu Gly Ser Leu Lys Lys 
65                  70                  75                  80  


Glu Leu Ala Lys Lys Arg Ile Asn Glu Glu Lys Ile Glu Asn Ile Lys 
                85                  90                  95      


Ser Asn Ile Glu Glu Leu Lys Ser Gln Lys Glu Lys Leu Glu Asn Glu 
            100                 105                 110         


Leu Lys Asn Ile Lys Glu Tyr Arg Ser Asn Ile Asp Glu Glu Phe Lys 
        115                 120                 125             


Lys Met Tyr Val Asn Asp Leu Tyr Asn Val Leu Asn Lys Ile Ser Phe 
    130                 135                 140                 


Gln His Glu Asp Met Lys Ser Leu Val Thr Gln Arg Val Lys Lys Asp 
145                 150                 155                 160 


Phe Asn Asn Asp Val Lys Glu Ile Met Arg Gly Asp Arg Ser Val Arg 
                165                 170                 175     


Asn Tyr Lys Arg Asn Phe Pro Ile Leu Thr Arg Gly Arg Asp Leu Lys 
            180                 185                 190         


Phe Gln Tyr Phe Glu Lys Ser Glu Asp Ile Glu Ile Lys Trp Ile Glu 
        195                 200                 205             


Gly Ile Lys Phe Lys Cys Ile Leu Gly Arg Pro Ser Lys Ser Leu Glu 
    210                 215                 220                 


Leu Lys His Thr Leu His Lys Val Ile Asn Glu Glu Tyr Lys Ile Cys 
225                 230                 235                 240 


Asp Ser Ser Leu Gln Phe Asp Lys Asn Asn Asn Leu Ile Leu Asn Leu 
                245                 250                 255     


Thr Leu Asp Ile Pro Glu Asn Asn Lys Tyr Glu Lys Ile Glu Asn Arg 
            260                 265                 270         


Ile Val Gly Val Asp Leu Gly Leu Lys Ile Pro Ala Tyr Val Ala Leu 
        275                 280                 285             


Asn Asp Thr Arg Tyr Ile Arg Lys Ala Ile Gly Ser Ile Asn Asp Phe 
    290                 295                 300                 


Leu Lys Val Arg Thr Gln Ile Gln Ser Arg Ala Arg Lys Leu Gln Lys 
305                 310                 315                 320 


Ser Leu Gln Val Val Arg Gly Gly Lys Gly Arg Asn Lys Lys Met Lys 
                325                 330                 335     


Ala Leu Glu Arg Phe Arg Glu Lys Glu Arg Asn Phe Ala Arg Asn Tyr 
            340                 345                 350         


Asn His Phe Leu Ser Tyr Asn Ile Val Lys Phe Ala Leu Asp Asn Lys 
        355                 360                 365             


Ala Glu Gln Ile Asn Leu Glu Leu Leu Glu Met Lys Lys Thr Gln Asn 
    370                 375                 380                 


Lys Ser Ile Leu Arg Asn Trp Ser Tyr Tyr Gln Leu Gln Ser Phe Ile 
385                 390                 395                 400 


Glu Tyr Lys Ala Glu Arg Val Gly Ile Lys Val Lys Tyr Ile Asp Pro 
                405                 410                 415     


Tyr His Thr Ser Gln Ile Cys Ser Glu Cys Gly Asn Tyr Glu Glu Gly 
            420                 425                 430         


Gln Arg Val Glu Gln Asp Thr Phe Val Cys Lys Arg Cys Gly His Lys 
        435                 440                 445             


Ile Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Met Ser Asp Asn 
    450                 455                 460                 


Tyr Ile Ser Lys Lys Glu Glu Ser Gln Tyr Tyr Lys Asn Asn Lys Asn 
465                 470                 475                 480 


Met Val 
        


<210>  263
<211>  482
<212>  PRT
<213>  Clostridium botulinum

<400>  263

Met Asn Thr Val Arg Lys Ile Lys Leu Thr Ile Leu Gly Asp Thr Glu 
1               5                   10                  15      


Thr Arg Asn Lys Gln Tyr Lys Trp Ile Arg Asp Glu Gln Tyr Asn Gln 
            20                  25                  30          


Tyr Arg Ala Leu Asn Leu Ser Met Thr Tyr Met Val Thr Asn Leu Met 
        35                  40                  45              


Leu Lys Asn Asn Glu Ser Gly Leu Glu Asn Arg Lys Glu Lys Asp Ile 
    50                  55                  60                  


Leu Lys Ile Glu Asn Lys Ile Lys Lys Asp Glu Glu Asn Leu Lys Lys 
65                  70                  75                  80  


Glu Leu Ala Lys Lys Lys Ile Asn Glu Glu Lys Asn Glu Asn Ile Lys 
                85                  90                  95      


Ser Asn Ile Glu Glu Leu Lys Ser Glu Lys Glu Lys Leu Glu Asn Glu 
            100                 105                 110         


Leu Lys Asn Ile Lys Glu Tyr Arg Ser Asn Ile Asp Glu Glu Phe Lys 
        115                 120                 125             


Lys Met Tyr Val Asp Asp Leu Tyr Asn Val Leu Asn Lys Ile Ser Phe 
    130                 135                 140                 


Gln His Glu Asp Met Lys Ser Leu Val Thr Gln Arg Val Lys Lys Asp 
145                 150                 155                 160 


Phe Asn Asn Asp Val Lys Glu Ile Met Arg Gly Asp Arg Ser Val Arg 
                165                 170                 175     


Asn Tyr Lys Arg Asn Phe Pro Ile Leu Thr Arg Gly Arg Asp Leu Lys 
            180                 185                 190         


Phe Gln Tyr Ile Glu Lys Ser Glu Asp Ile Glu Ile Lys Trp Ile Glu 
        195                 200                 205             


Gly Ile Lys Phe Lys Cys Ile Leu Gly Lys Pro Ser Lys Ser Leu Glu 
    210                 215                 220                 


Leu Lys His Ala Leu His Lys Val Ile Asn Lys Glu Tyr Lys Val Cys 
225                 230                 235                 240 


Asp Ser Ser Leu Gln Phe Asp Lys Asn Asn Asn Leu Ile Leu Asn Leu 
                245                 250                 255     


Thr Leu Asp Ile Pro Gln Asp Asn Lys Tyr Glu Lys Ile Thr Asn Arg 
            260                 265                 270         


Val Val Gly Val Asp Leu Gly Leu Lys Ile Pro Ala Tyr Val Ala Leu 
        275                 280                 285             


Asn Asp Thr Lys Tyr Ile Arg Lys Ala Ile Gly Ser Ile Asp Asp Phe 
    290                 295                 300                 


Leu Lys Val Arg Thr Gln Ile Gln Ser Arg Val Arg Lys Leu Gln Lys 
305                 310                 315                 320 


Ser Leu Gln Val Val Arg Gly Gly Lys Gly Arg Asn Lys Lys Met Lys 
                325                 330                 335     


Ala Leu Glu Lys Phe Arg Glu Lys Glu Arg Asn Phe Ala Arg Asn Tyr 
            340                 345                 350         


Asn His Phe Leu Ser Tyr Asn Ile Val Lys Phe Ala Leu Asp Asn Lys 
        355                 360                 365             


Ala Glu Gln Ile Asn Leu Glu Leu Leu Glu Met Lys Lys Thr Gln Asn 
    370                 375                 380                 


Lys Ser Ile Leu Arg Asn Trp Ser Tyr Tyr Gln Leu Gln Asn Phe Ile 
385                 390                 395                 400 


Glu Tyr Lys Ala Glu Arg Val Gly Ile Lys Val Lys Tyr Ile Asp Pro 
                405                 410                 415     


Tyr His Thr Ser Gln Thr Cys Ser Glu Cys Gly Asn Tyr Glu Glu Gly 
            420                 425                 430         


Gln Arg Val Glu Gln Asp Thr Phe Val Cys Lys Arg Cys Trp His Lys 
        435                 440                 445             


Met Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Met Ser Tyr Asn 
    450                 455                 460                 


Tyr Ile Ser Lys Lys Glu Glu Ser Glu Tyr Tyr Lys Asn Asn Lys Asn 
465                 470                 475                 480 


Met Val 
        


<210>  264
<211>  424
<212>  PRT
<213>  Ruminiclostridium hungatei

<400>  264

Met Ala Thr Lys Val Met Arg Tyr Gln Ile Ile Lys Pro Ile Asp Cys 
1               5                   10                  15      


Asn Trp Asp Leu Phe Gly Lys Val Leu Arg Asp Ile Gln Tyr Asp Thr 
            20                  25                  30          


Arg Gln Ile Met Asn Arg Thr Ile Gln Tyr Cys Trp Glu Trp Gln Gly 
        35                  40                  45              


Tyr Ser Ser Asp Tyr Lys Ile Ala Lys Gly Glu Tyr Pro Lys Thr Arg 
    50                  55                  60                  


Glu Thr Phe Gly Tyr Ser Asp Met Arg Gly Tyr Ala Tyr Asp Lys Leu 
65                  70                  75                  80  


Lys Ser Ile Tyr Gln Arg Leu Asn Thr Ala Asn Leu Thr Thr Ser Ile 
                85                  90                  95      


Thr Arg Ala Val Gln Arg Trp Lys Thr Asp Thr Lys Asp Val Ile Arg 
            100                 105                 110         


Gly Asp Lys Ser Ile Ala Cys Phe Arg Ala Asp Val Pro Ile Asp Leu 
        115                 120                 125             


His Asn Lys Ser Met Asn Ile Glu Lys Ser Asp Asp Gly Tyr Ile Val 
    130                 135                 140                 


Ala Leu Ser Leu Ala Ser Asn Ile Tyr Lys Lys Glu Leu Asp Arg Asn 
145                 150                 155                 160 


Ser Gly Gln Phe Ser Val Leu Ile Asn Glu Gly Asn Lys Ser Asn Arg 
                165                 170                 175     


Asp Val Leu Asp Arg Cys Ile Ala Gly Gln Tyr Lys Ile Ser Ala Ser 
            180                 185                 190         


Gln Ile Leu Arg Glu Lys Asn Lys Trp Phe Leu Asn Leu Ser Tyr Ser 
        195                 200                 205             


Phe Glu Ile Ser Lys Pro Asp Lys Ser Arg Asp Asn Ile Leu Gly Ile 
    210                 215                 220                 


Asp Val Gly Ile Val His Pro Val Tyr Met Ala Val Tyr Asn Ser Pro 
225                 230                 235                 240 


Ala Arg Arg Ser Ile Ser Gly Gly Glu Ile Asp Asn Phe Arg Lys Gln 
                245                 250                 255     


Val Gln Lys Arg Ile Lys Glu Leu Gln Leu Gln Gly Lys Gln Cys Gly 
            260                 265                 270         


Glu Gly Arg Ile Gly His Gly Ile Lys Thr Arg Val Lys Pro Ile Glu 
        275                 280                 285             


Phe Ala Lys Asp Lys Val Ala Asn Phe Arg Asn Thr Ile Asn His Lys 
    290                 295                 300                 


Tyr Ser Lys Ala Ile Val Glu Phe Ala Ile Lys Asn Gly Cys Gly Ile 
305                 310                 315                 320 


Ile Gln Met Glu Asp Leu Lys Gly Ile Asn Thr Asp Asn Val Phe Leu 
                325                 330                 335     


Lys Asn Trp Thr Tyr Tyr Asp Leu Gln Gln Lys Val Lys Tyr Lys Ala 
            340                 345                 350         


Glu Leu Glu Gly Ile Glu Val Lys Leu Ile Asp Pro Gln Tyr Thr Ser 
        355                 360                 365             


Gln Arg Cys Cys Lys Cys Gly Tyr Ile His Arg Asp Asn Arg Pro Glu 
    370                 375                 380                 


Gln Ala Lys Phe Lys Cys Ile Asp Cys Gly Phe Glu Val Asn Ala Asp 
385                 390                 395                 400 


Tyr Asn Ala Ser Leu Asn Ile Ala Thr Pro Asp Ile Asp Lys Ile Ile 
                405                 410                 415     


Leu Glu Phe Leu Lys Cys Glu Thr 
            420                 


<210>  265
<211>  451
<212>  PRT
<213>  Desulfovibrio fructosivorans

<400>  265

Met Ala Ile Thr Lys Val Val Lys Ile Pro Leu Val Ile Asp Glu Ser 
1               5                   10                  15      


Asp Glu Ile Leu Arg Lys Ile Lys Tyr Arg Ala Phe Asp Lys Val Met 
            20                  25                  30          


Asn Glu Ala Arg Tyr Leu Gly Asn Leu Ala Ile Arg Tyr Ala Ile Ala 
        35                  40                  45              


Tyr Gly Leu Glu Asn Ile Pro Asn Gln Ile Asp Ala Glu Thr Gly Lys 
    50                  55                  60                  


Gln Ile Ala Leu Asp Thr Thr Ile Tyr Arg His Leu Ala Glu Lys Arg 
65                  70                  75                  80  


Lys Tyr Leu Pro Ala Gly Asn Met Ala Thr Leu Glu Arg Asn Phe Ala 
                85                  90                  95      


Val Lys Thr Tyr Arg Asn Thr Asn Lys Asp Ala Trp Ala Gly Arg Lys 
            100                 105                 110         


Ser Leu Pro Thr Tyr Arg Ser Leu Phe Val Pro Phe Arg His Thr Gly 
        115                 120                 125             


Thr Lys Ile Ala Val Val Glu Arg Asn Gly Thr Lys Gln Phe Cys Ile 
    130                 135                 140                 


Asp Pro Gln Gly Phe Gly Ala Ser Trp Leu Ser Asp Glu Leu Ile Ala 
145                 150                 155                 160 


Glu Val His Asp Gly Pro Ile Ala Ile Glu Lys Gln Arg Arg Lys Leu 
                165                 170                 175     


Thr Leu Val Ser Cys Phe Ser Trp Arg Asp Gln Gly Ala Val Glu Ile 
            180                 185                 190         


Val Gln Arg Ile Val Asn Gly Glu Tyr Lys Leu Ser Asp Gly Gln Ile 
        195                 200                 205             


Gln Met Gly Lys Lys Gly Leu Val Ala Leu Leu Pro Tyr Ser Phe Asp 
    210                 215                 220                 


Ala Ile Gln Pro Glu Leu Asp Pro Ala Arg Val Cys Gly Ile Asp Leu 
225                 230                 235                 240 


Gly Ala Val Ile Pro Ala Val Cys Ala Val Asn Phe Gly Pro Gln Arg 
                245                 250                 255     


Ala Tyr Leu Gly Glu Gly Lys Asp Val Trp Ala Ala Arg Ser Arg Phe 
            260                 265                 270         


Arg Ala Glu Arg Arg Arg Leu Gln Ser Arg Ala Gly Leu Tyr Ser Lys 
        275                 280                 285             


Thr Lys Asn Trp Arg Arg Ser Glu Lys Glu Asp Asn Trp Ile Gln Thr 
    290                 295                 300                 


Tyr Tyr His Ala Leu Thr Arg Lys Val Ile Lys Phe Cys Val Gln His 
305                 310                 315                 320 


Gly Cys Gly Thr Ile His Met Glu Asp Leu Ser Ser Leu Arg Gln Arg 
                325                 330                 335     


Asp Val Glu Ser Glu Phe Arg Arg Leu Leu Trp Val Pro Ser Lys Phe 
            340                 345                 350         


Phe Glu Leu Leu Ser Tyr Lys Ala Lys Glu Met Gly Ile Gly Ile Val 
        355                 360                 365             


Lys Ile Asn Pro Arg Asn Thr Ser Lys Arg Cys Ser Glu Cys Gly His 
    370                 375                 380                 


Ile Ser Lys Gly Asn Arg Lys Ser Gln Glu Lys Phe Val Cys Glu Lys 
385                 390                 395                 400 


Cys Gly Glu Gly Lys Arg Pro Val Asn Ala Asp Tyr Asn Ala Ala Arg 
                405                 410                 415     


Asn Ile Ala Leu Ala Thr Gly Asp Val Leu Leu His Gly Tyr Ile Glu 
            420                 425                 430         


Ser Glu Pro Asp Ala Leu Gly Glu Met Asp Gln Leu Trp Glu Gly Ala 
        435                 440                 445             


Gln Glu Ala 
    450     


<210>  266
<211>  451
<212>  PRT
<213>  Bacillus toyonensis

<400>  266

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys Gln Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Ile Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Gly Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Gly Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Met Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Val Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile Tyr Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Val Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Met Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  267
<211>  451
<212>  PRT
<213>  Clostridium paraputrificum

<400>  267

Met Arg Ile Met Asn Phe Asn Lys Cys Ile Lys Val Thr Leu Ile Lys 
1               5                   10                  15      


Cys Leu Asn Tyr Asp Tyr Arg Lys Val Lys Gln Ile Ile Lys Asp Phe 
            20                  25                  30          


Gln Tyr Lys Tyr Ser Lys Ala Tyr Asn Met Ala Thr Asn Tyr Leu Tyr 
        35                  40                  45              


Leu Trp Asp Thr Asn Ser Met Asn Leu Lys Asn Leu Tyr Asp Thr Lys 
    50                  55                  60                  


Ile Val Asp Lys Glu Leu Leu Gly Lys Ser Lys Gly Ala Trp Ile Glu 
65                  70                  75                  80  


Asn Arg Met Asn Glu Ile Ile Glu Gly Ala Leu Ser Asn Asn Val Ala 
                85                  90                  95      


Gln Ala Arg Gln Asp Ile Ile Asn Lys Tyr Asn Lys Cys Lys Lys Asp 
            100                 105                 110         


Gly Leu Phe Lys Gly Lys Val Ser Leu Pro Thr Tyr Lys Leu Asp Ser 
        115                 120                 125             


Lys Val Ile Val His Asn Val Ala Tyr Lys Leu Arg Asn His Asn Gly 
    130                 135                 140                 


Tyr Phe Ile Asp Ile Gly Leu Leu Asn Lys Gly Lys Gln Lys Glu Leu 
145                 150                 155                 160 


Asn Val Gly Arg Phe Glu Phe Gln Ile Asp Lys Leu Asp Gly Asn Lys 
                165                 170                 175     


Lys Ala Thr Ile Asn Lys Ile Ile Asn Gly Glu Tyr Lys Gln Gly Ser 
            180                 185                 190         


Ala Gln Ile Ser Ile Ser Lys Lys Gly Lys Ile Glu Leu Ile Ile Ser 
        195                 200                 205             


Tyr Ser Phe Asp Lys Glu Glu Ile Pro Val Leu Asp Asn Asn Arg Ile 
    210                 215                 220                 


Leu Gly Ile Asp Leu Gly Ile Thr Asn Val Ala Thr Met Ser Val Tyr 
225                 230                 235                 240 


Asp Ser Ile Lys Asp Glu Tyr Asp Tyr Phe Ser Trp Lys Thr Asn Val 
                245                 250                 255     


Ile Arg Gly Lys Glu Leu Ile Ala Phe Arg Gln Lys Tyr Tyr Asn Leu 
            260                 265                 270         


Arg Arg Asp Ile Ser Ile Ala Ser Lys Thr Ala Gly Lys Gly Arg Cys 
        275                 280                 285             


Gly His Gly Tyr Lys Thr Lys Met Lys Pro Val Asp Lys Val Arg Asn 
    290                 295                 300                 


Arg Ile Ala Asn Phe Ala Asp Thr Tyr Asn His Lys Ile Ser Lys Tyr 
305                 310                 315                 320 


Ile Val Glu Phe Ala Val Lys Asn Arg Cys Gly Ile Ile Gln Met Glu 
                325                 330                 335     


Asp Leu Ser Gly Ala Thr Ser Glu Val His Asn Lys Met Leu Lys Asp 
            340                 345                 350         


Trp Ser Tyr Tyr Asp Leu Gln Gln Lys Ile Glu Tyr Lys Ala Lys Glu 
        355                 360                 365             


Gln Gly Ile Glu Ile Lys Lys Val Asn Pro Lys Tyr Thr Ser Lys Arg 
    370                 375                 380                 


Cys Asn Asn Cys Gly Cys Ile His Glu Asp Asn Arg Asp Cys Lys Asn 
385                 390                 395                 400 


His Gln Ala Arg Phe Glu Cys Lys Val Cys Gly His Gly Lys Asp Thr 
                405                 410                 415     


Asp Val Asn Ala Asp Val Asn Ala Ser Arg Asn Ile Ala Ile Pro Asp 
            420                 425                 430         


Ile Asp Lys Ile Ile Glu Glu Thr Glu Ile Leu His Ser Glu Asn Lys 
        435                 440                 445             


Pro Ala Ser 
    450     


<210>  268
<211>  437
<212>  PRT
<213>  Clostridium ventriculi

<400>  268

Met Thr Thr Lys Cys Val Gln Val Ala Ile Glu Tyr Ser Ser Asn Asn 
1               5                   10                  15      


Ile Leu Lys Glu Val Asp Phe Tyr Lys Glu Leu Arg Asp Leu Gln Tyr 
            20                  25                  30          


Asn Ser Tyr Leu Ala Cys Asn Arg Ala Ile Ser Tyr Met Tyr Glu Asn 
        35                  40                  45              


Asp Met Gln Asn Phe Ile Ile Lys Glu Thr Asp Leu Pro Arg Ser Asp 
    50                  55                  60                  


Asp Lys Lys Leu Tyr Gly Lys Ser Phe Ala Ala Trp Ile Glu Asn Arg 
65                  70                  75                  80  


Met Asn Glu Tyr Met Pro Gly Ala Leu Ser Asn Asn Val Ala Gln Thr 
                85                  90                  95      


Arg Gln Phe Val Val Asn Arg Tyr Lys Asn Asp Lys Lys Ala Gly Leu 
            100                 105                 110         


Leu Lys Gly Asn Val Ser Leu Thr Thr Phe Lys Arg Thr Asn Pro Ile 
        115                 120                 125             


Ile Ile His Asn Asn Ala Tyr Asn Ile Ile Glu Thr Pro Lys Gly Leu 
    130                 135                 140                 


Gly Ala Glu Ile Gly Phe Phe Asn Leu Pro Lys Gln Lys Glu Leu Gly 
145                 150                 155                 160 


Ile Lys Arg Val Asn Phe Leu Phe Pro Lys Leu Gly Ser Ser Glu Lys 
                165                 170                 175     


Ser Ile Ile Arg Arg Leu Leu Asp Lys Ser Tyr Lys Gln Gly Ala Met 
            180                 185                 190         


Gln Ile Ser Tyr Asn Gln Lys Lys Lys Lys Trp Met Ala Thr Ile Ser 
        195                 200                 205             


Phe Ser Phe Asn Leu Glu Glu Ile Lys Thr Asn Glu Asn Leu Val Met 
    210                 215                 220                 


Gly Ile Asp Leu Gly Val Ser Lys Val Ala Thr Leu Ser Ile Tyr Asp 
225                 230                 235                 240 


Ala Ser Lys Tyr Glu Tyr Ile Lys Met Ser Phe Lys Asp Thr Cys Ile 
                245                 250                 255     


Asp Gly Thr Glu Leu Met His Tyr Arg Gln Lys Leu Glu Ser Arg Arg 
            260                 265                 270         


Lys Ala Leu Ser Ile Ala Ser Lys Trp Ala Ser Asp Asn Asn Arg Gly 
        275                 280                 285             


His Gly Tyr Lys Thr Lys Met Glu Lys Ala Asn Tyr Met Gly Arg Lys 
    290                 295                 300                 


Tyr Asn Asn Phe Arg Asp Thr Tyr Asn His Lys Val Ser Arg Tyr Ile 
305                 310                 315                 320 


Val Asp Val Ala Ile Lys Tyr Arg Val Gly Leu Ile Gln Met Glu Asp 
                325                 330                 335     


Leu Ser Gly Phe Ser Glu Gln Gln Gln Glu Ser Leu Leu Lys Asn Trp 
            340                 345                 350         


Ser Tyr Tyr Asp Leu Gln Gln Lys Ile Lys Tyr Lys Ala Glu Glu Asn 
        355                 360                 365             


Gly Ile Arg Val Tyr Phe Ile Asn Pro Lys Tyr Thr Ser Gln Arg Cys 
    370                 375                 380                 


Ser Lys Cys Gly Asn Ile Asp Lys Glu Asn Arg Lys Thr Gln Glu Ser 
385                 390                 395                 400 


Phe Ser Cys Thr Val Cys Asn Tyr Lys Asp Asn Ala Asp Val Asn Ala 
                405                 410                 415     


Ser Lys Asn Ile Ala Ile Pro Asp Ile Glu Lys Ile Ile Glu Glu Gln 
            420                 425                 430         


Val Lys Lys Gln Tyr 
        435         


<210>  269
<211>  440
<212>  PRT
<213>  Ruminococcus sp.

<400>  269

Met Val Lys Val Val Lys Ile His Leu Ile Ser Glu Gln Phe Asp Lys 
1               5                   10                  15      


Ala Gly Asn Arg Ile Asp Tyr Glu Glu Val Asn Lys Ile Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Thr Val Gln Leu Leu 
        35                  40                  45              


Trp Glu Trp Asn Asn Phe Ser Ser Asp Tyr Val Lys Ala Ser Gly Ile 
    50                  55                  60                  


Tyr Pro Lys Ala Lys Asp Ile Phe Gly Tyr Ser Ser Val His Gly Gln 
65                  70                  75                  80  


Ala Asn Lys Glu Leu Arg Thr Lys Leu Ala Leu Asn Ser Ser Asn Leu 
                85                  90                  95      


Ser Thr Thr Thr Met Asp Val Cys Lys Asn Phe Asn Thr Tyr Lys Lys 
            100                 105                 110         


Glu Val Trp Lys Gly Lys Arg Ser Val Pro Ser Tyr Lys Ser Asp Gln 
        115                 120                 125             


Pro Leu Asp Leu His Lys Asp Ser Ile Lys Leu Ile Tyr Glu Asn Asn 
    130                 135                 140                 


Gln Phe Tyr Val Arg Leu Ala Leu Leu Lys Lys Ala Glu Phe Ala Lys 
145                 150                 155                 160 


Tyr Gly Phe Lys Asp Gly Phe His Phe Lys Met Gln Val Lys Asp Asn 
                165                 170                 175     


Ser Thr Lys Thr Ile Leu Glu Arg Cys Phe Asp Glu Val Tyr Lys Ile 
            180                 185                 190         


Asn Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Lys Trp Lys Leu 
        195                 200                 205             


Asn Leu Ser Tyr Ser Phe Asp Asn Lys Asn Ile Ser Glu Leu Asp Lys 
    210                 215                 220                 


Glu Lys Ile Leu Gly Val Asp Val Gly Val Ser Tyr Pro Leu Val Ala 
225                 230                 235                 240 


Ser Val Phe Gly Asp Arg Asp Arg Phe Lys Ile Lys Gly Gly Glu Ile 
                245                 250                 255     


Glu Lys Phe Arg Lys Ser Val Glu Ala Arg Arg Arg Ser Met Leu Glu 
            260                 265                 270         


Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Arg Lys Lys 
        275                 280                 285             


Arg Thr Glu Pro Ala Leu Asn Ile Gly Asp Lys Ile Ala Arg Phe Arg 
    290                 295                 300                 


Asp Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr Ala Val 
305                 310                 315                 320 


Lys Lys Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr Gly Ile Thr 
                325                 330                 335     


Ser Lys Ala Asp Arg Phe Leu Lys Asp Trp Thr Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Thr Lys Ile Glu Asn Lys Ala Lys Glu Val Gly Ile Asn Val Val Tyr 
        355                 360                 365             


Ile Ala Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly Tyr Ile 
    370                 375                 380                 


His Lys Asp Asn Arg Pro Asn Gln Ala Lys Phe Arg Cys Leu Glu Cys 
385                 390                 395                 400 


Asp Phe Glu Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Gly Ile 
                405                 410                 415     


Lys Asn Ile Asp Lys Ile Ile Glu Lys Asp Leu Gln Lys Gln Glu Ser 
            420                 425                 430         


Glu Val Gln Val Asn Glu Asn Lys 
        435                 440 


<210>  270
<211>  439
<212>  PRT
<213>  Ruminococcus sp.

<400>  270

Met Val Lys Val Val Lys Ile His Leu Ile Ser Glu Gln Phe Asp Lys 
1               5                   10                  15      


Ala Gly Asn Arg Ile Asp Tyr Lys Glu Val Asn Lys Ile Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Thr Val Gln Leu Leu 
        35                  40                  45              


Trp Glu Trp Asn Asn Phe Ser Ser Asp Tyr Val Lys Ala Ser Gly Ile 
    50                  55                  60                  


Tyr Pro Lys Ala Lys Asp Ile Phe Gly Tyr Ser Ser Val His Gly Gln 
65                  70                  75                  80  


Ala Asn Lys Glu Leu Arg Thr Lys Leu Ala Leu Asn Ser Ser Asn Leu 
                85                  90                  95      


Ser Thr Thr Thr Met Asp Val Cys Lys Asn Phe Asn Thr Tyr Lys Lys 
            100                 105                 110         


Glu Val Trp Lys Gly Lys Arg Ser Val Pro Ser Tyr Lys Ser Asp Gln 
        115                 120                 125             


Pro Leu Asp Leu His Lys Asp Ser Ile Lys Leu Ile Tyr Glu Asn Asn 
    130                 135                 140                 


Gln Phe Tyr Val Arg Leu Ala Leu Leu Lys Lys Ala Gly Phe Ala Lys 
145                 150                 155                 160 


Tyr Gly Phe Lys Asp Gly Phe Arg Phe Lys Met Gln Val Lys Asp Asn 
                165                 170                 175     


Ser Thr Lys Thr Ile Leu Glu Arg Cys Phe Asp Gly Ile Tyr Thr Ile 
            180                 185                 190         


Val Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Asn Arg Trp Lys Leu 
        195                 200                 205             


Asn Leu Ser Tyr Ser Phe Asp Asn Lys Asn Ile Ser Glu Leu Asp Lys 
    210                 215                 220                 


Glu Lys Ile Leu Gly Val Asp Val Gly Val Ser Tyr Pro Leu Val Ala 
225                 230                 235                 240 


Ser Val Phe Gly Asp Arg Asp Arg Phe Lys Ile Lys Gly Gly Glu Ile 
                245                 250                 255     


Glu Lys Phe Arg Lys Ser Val Glu Ala Arg Arg Arg Ser Met Leu Glu 
            260                 265                 270         


Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Arg Lys Lys 
        275                 280                 285             


Arg Thr Glu Pro Ala Leu Asn Ile Gly Asp Lys Ile Ala Arg Phe Arg 
    290                 295                 300                 


Asp Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr Ala Val 
305                 310                 315                 320 


Lys Lys Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr Gly Ile Thr 
                325                 330                 335     


Ser Lys Ser Asp Arg Phe Leu Lys Asp Trp Thr Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Thr Lys Ile Glu Ser Lys Ala Asn Glu Ala Gly Ile Lys Val Val Tyr 
        355                 360                 365             


Ile Ala Pro Glu Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly Tyr Ile 
    370                 375                 380                 


His Lys Asp Asn Arg Pro Asn Gln Ala Lys Phe Arg Cys Leu Lys Cys 
385                 390                 395                 400 


Asp Phe Glu Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Gly Ile 
                405                 410                 415     


Lys Asn Ile Asp Lys Thr Ile Lys Lys Glu Arg Lys Lys Gln Lys Ser 
            420                 425                 430         


Glu Ala Gln Val Asn Glu Lys 
        435                 


<210>  271
<211>  402
<212>  PRT
<213>  Peptoclostridium sp.

<400>  271

Met Ile Thr Val Arg Lys Leu Lys Leu Thr Ile Ile Asn Asp Asp Glu 
1               5                   10                  15      


Thr Lys Arg Asn Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln Tyr Ala 
            20                  25                  30          


Gln Tyr Gln Gly Leu Asn Leu Ala Met Ser Val Leu Thr Asn Ala Tyr 
        35                  40                  45              


Leu Ser Ala Asn Arg Asp Ile Lys Ser Asp Leu Phe Lys Glu Thr Gln 
    50                  55                  60                  


Lys Asn Leu Lys Asn Ser Ser Ser Ile Phe Asn Asp Ile Pro Phe Gly 
65                  70                  75                  80  


Lys Gly Ile Asp Ser Lys Ser Ser Ile Thr Gln Lys Val Lys Gln Asp 
                85                  90                  95      


Phe Ser Ile Ala Ile Lys Asn Gly Leu Ala Gly Gly Glu Arg Asn Ile 
            100                 105                 110         


Thr Asn Tyr Lys Arg Thr Phe Pro Leu Met Thr Arg Gly Arg Asp Leu 
        115                 120                 125             


Lys Phe Ser Tyr Lys Asp Asp Cys Ser Asp Glu Ile Ile Ile Lys Trp 
    130                 135                 140                 


Val Asn Lys Ile Val Phe Lys Val Val Ile Gly Arg Lys Asp Lys Asn 
145                 150                 155                 160 


Tyr Leu Glu Leu Met His Thr Leu Asn Lys Val Ile Asn Gly Glu Tyr 
                165                 170                 175     


Lys Val Gly Gln Ser Ser Ile Tyr Phe Asp Lys Ser Asn Lys Leu Ile 
            180                 185                 190         


Leu Asn Leu Thr Leu Tyr Ile Pro Glu Lys Lys Asp Asp Asp Ala Ile 
        195                 200                 205             


Asn Gly Arg Thr Leu Gly Val Asp Leu Gly Ile Lys Tyr Pro Ala Tyr 
    210                 215                 220                 


Val Cys Leu Asn Asp Asp Thr Phe Ile Arg Gln His Ile Gly Glu Ser 
225                 230                 235                 240 


Leu Glu Leu Ser Lys Gln Arg Glu Gln Phe Arg Asn Arg Arg Lys Arg 
                245                 250                 255     


Leu Gln Gln Gln Leu Lys Asn Val Lys Gly Gly Lys Gly Arg Glu Lys 
            260                 265                 270         


Lys Leu Ser Ala Leu Asp Lys Val Ala Val Cys Glu Arg Asn Phe Val 
        275                 280                 285             


Lys Thr Tyr Asn His Thr Ile Ser Lys Arg Ile Val Asp Phe Ala Lys 
    290                 295                 300                 


Lys Asn Lys Cys Glu Phe Ile Asn Leu Glu Gln Leu Thr Lys Asp Gly 
305                 310                 315                 320 


Phe Asp Asn Ile Ile Leu Ser Asn Trp Ser Tyr Tyr Glu Leu Gln Asn 
                325                 330                 335     


Met Ile Lys Tyr Lys Ala Asp Arg Glu Gly Ile Lys Val Arg Tyr Val 
            340                 345                 350         


Asn Pro Ala Tyr Thr Ser Gln Lys Cys Ser Lys Cys Gly Tyr Ile Asp 
        355                 360                 365             


Lys Glu Asn Arg Pro Thr Gln Glu Lys Phe Lys Cys Ile Lys Cys Gly 
    370                 375                 380                 


Phe Glu Leu Asn Ala Asp His Asn Ala Ala Ile Asn Ile Ser Arg Leu 
385                 390                 395                 400 


Glu Glu 
        


<210>  272
<211>  493
<212>  PRT
<213>  Bacillus sp.

<400>  272

Met Ile Thr Val Arg Lys Leu Lys Leu Ala Ile Val Ser Gly Asn Glu 
1               5                   10                  15      


Asn Glu Thr Tyr Gln Phe Leu Arg Asn Glu Met Arg Asn Gln Tyr Lys 
            20                  25                  30          


Ala Leu Asn Ile Ser Tyr Ser His Leu Tyr Phe Glu Tyr Ile Ala Gln 
        35                  40                  45              


Glu Lys Ile Lys His Ser Asn Glu Glu Tyr Gln Gln His Leu Thr Lys 
    50                  55                  60                  


Tyr Thr Glu Lys Ala Gln Glu Lys Tyr Gln Asn Tyr Leu Lys Cys Lys 
65                  70                  75                  80  


Gly Lys Ala Glu Val Phe Lys Asp Asp Gln Gln Leu Gln Lys Arg Val 
                85                  90                  95      


Glu Lys Ala Arg Asp Asp Tyr Asn Lys Ala Gln Glu Lys Val Tyr Lys 
            100                 105                 110         


Ile Glu Lys Gln Tyr Ser Lys Lys Ala Ser Glu Ile Tyr Gln Lys Ala 
        115                 120                 125             


Val Gly Leu Val Lys Gln Thr Arg Ile Gly Lys Leu Ile Asn Ser Lys 
    130                 135                 140                 


Phe Asp Leu His Tyr Asp Thr Val Asp Arg Ile Thr Ser Thr Val Ile 
145                 150                 155                 160 


Ser His Phe Thr Cys Asp Met Lys Ala Gly Leu Leu Asn Gly Lys Arg 
                165                 170                 175     


Asn Leu Arg Asn Tyr Lys Glu Thr Asn Pro Leu Met Ile Arg Ala Arg 
            180                 185                 190         


Ser Met Val Leu Tyr Glu Glu Ser Gly Asp Tyr Phe Ile Lys Trp Ile 
        195                 200                 205             


Lys Gly Ile Thr Phe Lys Val Ile Leu Leu Glu Ser Ser Lys Gln Arg 
    210                 215                 220                 


Ala Asn Ile Asn Glu Leu Lys Ser Leu Leu Val Asn Ile Ile Glu Gly 
225                 230                 235                 240 


Asn Tyr Lys Ile Cys Asp Ser Ser Ile Ala Ile Asn Lys Lys Leu Ile 
                245                 250                 255     


Leu Asn Leu Ser Leu Asn Ile Pro Val Ser Arg Lys Asn Ser Phe Met 
            260                 265                 270         


Lys Gly Arg Val Val Gly Leu Asp Leu Gly Leu Arg Ile Pro Ala Tyr 
        275                 280                 285             


Val Ser Ile Asn Asp Lys Pro Tyr Ile Arg Lys Ser Ile Gly Ser Ile 
    290                 295                 300                 


Glu Asp Phe Leu Lys Val Arg Thr Gln Ile Gln Ser Gln Arg Lys Arg 
305                 310                 315                 320 


Leu Gln Lys Ala Leu Gln Ser Thr Arg Gly Gly Lys Gly Lys Asn Lys 
                325                 330                 335     


Lys Leu Gln Gly Leu Asn Arg Ile Lys Glu Lys Glu Lys Asn Phe Val 
            340                 345                 350         


Asn Thr Tyr Asn His Phe Ile Ser Ser Lys Ile Val Gln Phe Ala Leu 
        355                 360                 365             


Lys Asn Gln Ala Gly Ile Ile His Met Glu Tyr Leu Glu Phe Asp Arg 
    370                 375                 380                 


Met Lys Asn Lys Ser Leu Leu Arg Asn Trp Ser Tyr Tyr Gln Leu Gln 
385                 390                 395                 400 


Gln Met Ile Glu Tyr Lys Ala Lys Arg Glu Gly Ile Glu Val Lys Tyr 
                405                 410                 415     


Ile Asp Ala His Tyr Thr Ser Gln Thr Cys Ser Lys Cys Asn His Tyr 
            420                 425                 430         


Glu Leu Gly Gln Arg Glu Ile Gln Glu Lys Phe Ser Cys Lys Ser Cys 
        435                 440                 445             


Gly Phe Asn Ala Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ala Asn 
    450                 455                 460                 


Ser Ile Lys Phe Ile Thr Thr Asn Lys Lys Ile Ile Glu Glu Leu Glu 
465                 470                 475                 480 


Val Glu Glu Lys Gln Leu Ser Leu Asp Phe Asn Gly Ser 
                485                 490             


<210>  273
<211>  421
<212>  PRT
<213>  Clostridioides difficile

<400>  273

Met Leu Tyr Leu Pro Lys Tyr Ala Ile Ile Leu Leu Thr Cys Arg Ile 
1               5                   10                  15      


Arg Met Val Ala Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val 
            20                  25                  30          


Glu Glu Glu Glu Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser 
        35                  40                  45              


Gln Tyr Ala Gln Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr 
    50                  55                  60                  


Ser Ala Tyr Leu Val Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys 
65                  70                  75                  80  


Asp Ser Gln Lys Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile 
                85                  90                  95      


Asn Phe Gly Lys Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val 
            100                 105                 110         


Lys Lys Asp Phe Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu 
        115                 120                 125             


Arg Gly Phe Thr Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly 
    130                 135                 140                 


Arg Asp Leu Lys Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp 
145                 150                 155                 160 


Val Asn Lys Ile Val Phe Lys Ile Leu Ile Gly Arg Lys Asp Lys Asn 
                165                 170                 175     


Lys Val Glu Leu Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr 
            180                 185                 190         


Lys Val Ser Gln Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile 
        195                 200                 205             


Leu Asn Leu Thr Ile Asp Ile Pro Tyr Lys Lys Val Asp Glu Ile Val 
    210                 215                 220                 


Lys Asp Arg Val Cys Gly Val Asp Met Gly Ile Ala Ile Pro Ile Tyr 
225                 230                 235                 240 


Val Ala Leu Asn Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile 
                245                 250                 255     


Asp Glu Phe Met Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg 
            260                 265                 270         


Leu Gln Gln Gln Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp 
        275                 280                 285             


Lys Leu Lys Gly Leu Glu Ser Leu Arg Glu Lys Glu Lys Ser Trp Val 
    290                 295                 300                 


Lys Thr Tyr Asn His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys 
305                 310                 315                 320 


Lys Asn Lys Cys Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly 
                325                 330                 335     


Phe Gly Asp Arg Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu 
            340                 345                 350         


Met Ile Lys Tyr Lys Ala Asp Arg Val Gly Ile Lys Val Lys His Val 
        355                 360                 365             


Asn Pro Ala Tyr Thr Ser Gln Thr Cys Ser Glu Cys Gly His Ala Asp 
    370                 375                 380                 


Lys Glu Asn Arg Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly 
385                 390                 395                 400 


Phe Glu Ala Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser 
                405                 410                 415     


Asp Lys Phe Val Lys 
            420     


<210>  274
<211>  421
<212>  PRT
<213>  Clostridioides difficile

<400>  274

Met Leu Tyr Leu Pro Lys Tyr Ala Ile Ile Leu Leu Thr Cys Arg Ile 
1               5                   10                  15      


Arg Met Val Ala Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val 
            20                  25                  30          


Glu Glu Glu Glu Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser 
        35                  40                  45              


Gln Tyr Ala Gln Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr 
    50                  55                  60                  


Ser Ala Tyr Leu Ala Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys 
65                  70                  75                  80  


Asp Ser Gln Lys Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile 
                85                  90                  95      


Asn Phe Gly Lys Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val 
            100                 105                 110         


Lys Lys Asp Phe Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu 
        115                 120                 125             


Arg Gly Phe Thr Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly 
    130                 135                 140                 


Arg Asp Leu Lys Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp 
145                 150                 155                 160 


Val Asn Lys Ile Val Phe Lys Ile Leu Ile Gly Arg Lys Asp Lys Asn 
                165                 170                 175     


Lys Val Glu Leu Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr 
            180                 185                 190         


Lys Val Ser Gln Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile 
        195                 200                 205             


Leu Asn Leu Thr Ile Asp Ile Pro Tyr Lys Gln Val Asp Glu Ile Val 
    210                 215                 220                 


Lys Gly Arg Val Cys Gly Val Asp Met Gly Ile Ala Ile Pro Val Tyr 
225                 230                 235                 240 


Val Ala Leu Asn Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile 
                245                 250                 255     


Asp Glu Phe Met Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg 
            260                 265                 270         


Leu Gln Gln Gln Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp 
        275                 280                 285             


Lys Leu Lys Gly Leu Glu Ser Leu Arg Glu Lys Glu Lys Ser Trp Val 
    290                 295                 300                 


Lys Thr Tyr Asn His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys 
305                 310                 315                 320 


Lys Asn Lys Cys Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly 
                325                 330                 335     


Phe Gly Asp Arg Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu 
            340                 345                 350         


Met Ile Lys Tyr Lys Ala Asp Arg Val Gly Ile Lys Val Lys His Val 
        355                 360                 365             


Asn Pro Ser Tyr Thr Ser Gln Thr Cys Ser Glu Cys Gly His Val Asp 
    370                 375                 380                 


Lys Glu Asn Arg Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly 
385                 390                 395                 400 


Phe Glu Ala Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser 
                405                 410                 415     


Asp Lys Phe Val Lys 
            420     


<210>  275
<211>  507
<212>  PRT
<213>  Unknown

<220>
<223>  uncultured archaeon

<400>  275

Met Glu Glu Ala Lys Thr Val Ser Lys Thr Leu Ser Leu Arg Ile Leu 
1               5                   10                  15      


Arg Pro Leu Tyr Ser Ala Glu Ile Glu Lys Glu Ile Lys Glu Glu Lys 
            20                  25                  30          


Glu Arg Arg Lys Gln Gly Gly Lys Ser Gly Glu Leu Asp Ser Gly Phe 
        35                  40                  45              


Tyr Lys Lys Leu Glu Lys Lys His Thr Gln Met Phe Gly Trp Asp Lys 
    50                  55                  60                  


Leu Asn Leu Met Leu Ser Gln Leu Gln Arg Gln Ile Ala Arg Val Phe 
65                  70                  75                  80  


Asn Gln Ser Ile Ser Glu Leu Tyr Ile Glu Thr Val Ile Gln Gly Lys 
                85                  90                  95      


Lys Ser Asn Lys His Tyr Thr Ser Lys Ile Val Tyr Asn Arg Ala Tyr 
            100                 105                 110         


Ser Val Phe Tyr Asn Ala Tyr Leu Ala Leu Gly Ile Thr Ser Lys Val 
        115                 120                 125             


Glu Ala Asn Phe Arg Ser Thr Glu Leu Leu Met Gln Lys Ser Ser Leu 
    130                 135                 140                 


Pro Thr Ala Lys Ser Asp Asn Phe Pro Ile Leu Leu His Lys Gln Lys 
145                 150                 155                 160 


Gly Val Glu Gly Glu Glu Gly Gly Phe Lys Ile Ser Ala Asp Gly Asn 
                165                 170                 175     


Asp Leu Ile Phe Glu Ile Pro Ile Pro Phe Tyr Glu Tyr Asp Ser Ala 
            180                 185                 190         


Asn Lys Lys Glu Pro Phe Lys Trp Ile Lys Lys Gly Gly Gln Lys Pro 
        195                 200                 205             


Thr Ile Lys Leu Ile Leu Ser Thr Phe Arg Arg Gln Arg Asn Lys Gly 
    210                 215                 220                 


Trp Ala Lys Asp Glu Gly Thr Asp Ala Glu Ile Arg Lys Val Ile Glu 
225                 230                 235                 240 


Gly Lys Tyr Gln Val Ser His Ile Glu Ile Asn Arg Gly Lys Lys Leu 
                245                 250                 255     


Gly Asp His Gln Lys Trp Phe Val Asn Phe Thr Ile Glu Gln Pro Ile 
            260                 265                 270         


Tyr Glu Arg Lys Leu Asp Lys Asn Ile Ile Gly Gly Ile Asp Val Gly 
        275                 280                 285             


Ile Lys Ser Pro Leu Val Cys Ala Val Asn Asn Ser Phe Ala Arg Tyr 
    290                 295                 300                 


Ser Val Asp Ser Asn Asp Val Leu Lys Phe Ser Lys Gln Ala Phe Ala 
305                 310                 315                 320 


Phe Arg Arg Arg Leu Leu Ser Lys Asn Ser Leu Lys Arg Ser Gly His 
                325                 330                 335     


Gly Ser Lys Asn Lys Leu Asp Pro Ile Thr Arg Met Thr Glu Lys Asn 
            340                 345                 350         


Asp Arg Phe Arg Lys Lys Ile Ile Glu Arg Trp Ala Lys Glu Val Thr 
        355                 360                 365             


Asn Phe Phe Ile Lys Asn Gln Val Gly Thr Val Gln Ile Glu Asp Leu 
    370                 375                 380                 


Ser Thr Met Lys Asp Arg Gln Asp Asn Phe Phe Asn Gln Tyr Leu Arg 
385                 390                 395                 400 


Gly Phe Trp Pro Tyr Tyr Gln Met Gln Asn Leu Ile Glu Asn Lys Leu 
                405                 410                 415     


Lys Glu Tyr Gly Ile Glu Thr Lys Arg Ile Lys Ala Arg Tyr Thr Ser 
            420                 425                 430         


Gln Leu Cys Ser Asn Pro Ser Cys Arg His Trp Asn Ser Tyr Phe Ser 
        435                 440                 445             


Phe Asp His Arg Lys Thr Asn Asn Phe Pro Lys Phe Lys Cys Glu Lys 
    450                 455                 460                 


Cys Ala Leu Glu Ile Ser Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ser 
465                 470                 475                 480 


Thr Pro Asp Ile Glu Lys Phe Val Ala Lys Ala Thr Lys Gly Ile Asn 
                485                 490                 495     


Leu Pro Asp Lys Asn Glu Asn Val Ile Leu Glu 
            500                 505         


<210>  276
<211>  541
<212>  PRT
<213>  Unknown

<220>
<223>  uncultured archaeon

<400>  276

Met Trp Thr Ile Val Ile Gly Asp Phe Ile Glu Met Pro Lys Gln Asp 
1               5                   10                  15      


Leu Val Thr Thr Gly Ile Lys Phe Lys Leu Asp Val Asp Lys Glu Thr 
            20                  25                  30          


Arg Lys Lys Leu Asp Asp Tyr Phe Asp Glu Tyr Gly Lys Ala Ile Asn 
        35                  40                  45              


Phe Ala Val Lys Ile Ile Gln Lys Asn Leu Lys Glu Asp Arg Phe Ala 
    50                  55                  60                  


Gly Lys Ile Ala Leu Gly Glu Asp Lys Lys Pro Leu Leu Asp Lys Asp 
65                  70                  75                  80  


Gly Lys Lys Ile Tyr Asn Tyr Pro Asn Glu Ser Cys Ser Cys Gly Asn 
                85                  90                  95      


Gln Val Arg Arg Tyr Val Asn Ala Lys Pro Phe Cys Val Asp Cys Tyr 
            100                 105                 110         


Lys Leu Lys Phe Thr Glu Asn Gly Ile Arg Lys Arg Met Tyr Ser Ala 
        115                 120                 125             


Arg Gly Arg Lys Ala Asp Ser Asp Ile Asn Ile Lys Asn Ser Thr Asn 
    130                 135                 140                 


Lys Ile Ser Lys Thr His Phe Asn Tyr Ala Ile Arg Glu Gly Phe Ile 
145                 150                 155                 160 


Leu Asp Lys Ser Leu Lys Lys Gln Arg Ser Lys Arg Ile Lys Lys Leu 
                165                 170                 175     


Leu Glu Leu Lys Arg Lys Leu Gln Glu Phe Ile Asp Ile Arg Gln Gly 
            180                 185                 190         


Gln Met Val Leu Cys Pro Lys Ile Lys Asn Gln Arg Val Asp Lys Phe 
        195                 200                 205             


Ile His Pro Ser Trp Leu Lys Arg Asp Lys Lys Leu Glu Glu Phe Arg 
    210                 215                 220                 


Gly Tyr Ser Leu Ser Val Val Glu Gly Lys Ile Lys Ile Phe Asn Arg 
225                 230                 235                 240 


Asn Ile Leu Arg Glu Glu Asp Ser Leu Arg Gln Arg Gly His Val Asn 
                245                 250                 255     


Phe Lys Ala Asn Arg Ile Met Leu Asp Lys Ser Val Arg Phe Leu Asp 
            260                 265                 270         


Gly Gly Lys Val Asn Phe Asn Leu Asn Lys Gly Leu Pro Lys Glu Tyr 
        275                 280                 285             


Leu Leu Asp Leu Pro Lys Lys Glu Asn Lys Leu Ser Trp Leu Asn Glu 
    290                 295                 300                 


Lys Ile Ser Leu Ile Lys Leu Gln Lys Pro Lys Tyr Ala Tyr Leu Leu 
305                 310                 315                 320 


Arg Arg Glu Gly Ser Phe Phe Ile Gln Tyr Thr Ile Glu Asn Val Pro 
                325                 330                 335     


Lys Thr Phe Ser Asp Tyr Leu Gly Ala Ile Gly Ile Asp Arg Gly Ile 
            340                 345                 350         


Ser His Ile Ala Val Cys Thr Phe Val Ser Lys Asn Gly Val Asn Lys 
        355                 360                 365             


Ala Pro Val Phe Phe Ser Ser Gly Glu Ile Leu Lys Leu Lys Ser Leu 
    370                 375                 380                 


Gln Lys Gln Arg Asp Leu Phe Leu Arg Gly Lys His Asn Lys Ile Arg 
385                 390                 395                 400 


Lys Lys Ser Asn Met Arg Asn Ile Asp Asn Lys Ile Asn Leu Ile Leu 
                405                 410                 415     


His Lys Tyr Ser Arg Asn Ile Val Asn Leu Ala Lys Ser Glu Lys Ala 
            420                 425                 430         


Phe Ile Val Phe Glu Lys Leu Glu Lys Ile Lys Lys Ser Arg Phe Lys 
        435                 440                 445             


Met Ser Lys Ser Leu Gln Tyr Lys Leu Ser Gln Phe Thr Phe Lys Lys 
    450                 455                 460                 


Leu Ser Asp Leu Val Glu Tyr Lys Ala Lys Ile Glu Gly Ile Lys Val 
465                 470                 475                 480 


Asp Tyr Val Pro Pro Glu Tyr Thr Ser Lys Glu Cys Ser His Cys Gly 
                485                 490                 495     


Glu Lys Val Asp Thr Gln Arg Pro Phe Asn Gly Asn Ser Ser Leu Phe 
            500                 505                 510         


Lys Cys Asn Lys Cys Arg Val Gln Leu Asn Ala Asp Tyr Asn Ala Ser 
        515                 520                 525             


Ile Asn Ile Ala Lys Lys Ser Leu Asn Ile Ser Asn Asn 
    530                 535                 540     


<210>  277
<211>  537
<212>  PRT
<213>  Unknown

<220>
<223>  uncultured archaeon

<400>  277

Met Glu Glu Ser Ile Ile Thr Gly Val Lys Phe Lys Leu Arg Ile Asp 
1               5                   10                  15      


Lys Glu Thr Thr Lys Lys Leu Asn Glu Tyr Phe Asp Glu Tyr Gly Lys 
            20                  25                  30          


Ala Ile Asn Phe Ala Val Lys Ile Ile Gln Lys Glu Leu Ala Asp Asp 
        35                  40                  45              


Arg Phe Ala Gly Lys Ala Lys Leu Asp Gln Asn Lys Asn Pro Ile Leu 
    50                  55                  60                  


Asp Glu Asn Gly Lys Lys Ile Tyr Glu Phe Pro Asp Glu Phe Cys Ser 
65                  70                  75                  80  


Cys Gly Lys Gln Val Asn Lys Tyr Val Asn Asn Lys Pro Phe Cys Gln 
                85                  90                  95      


Glu Cys Tyr Lys Ile Arg Phe Thr Glu Asn Gly Ile Arg Lys Arg Met 
            100                 105                 110         


Tyr Ser Ala Lys Gly Arg Lys Ala Glu His Lys Ile Asn Ile Leu Asn 
        115                 120                 125             


Ser Thr Asn Lys Ile Ser Lys Thr His Phe Asn Tyr Ala Ile Arg Glu 
    130                 135                 140                 


Ala Phe Ile Leu Asp Lys Ser Ile Lys Lys Gln Arg Lys Lys Arg Asn 
145                 150                 155                 160 


Glu Arg Leu Arg Glu Ser Lys Lys Arg Leu Gln Gln Phe Ile Asp Met 
                165                 170                 175     


Arg Asp Gly Lys Arg Glu Ile Cys Pro Thr Ile Lys Gly Gln Lys Val 
            180                 185                 190         


Asp Arg Phe Ile His Pro Ser Trp Ile Thr Lys Asp Lys Lys Leu Glu 
        195                 200                 205             


Asp Phe Arg Gly Tyr Thr Leu Ser Ile Ile Asn Ser Lys Ile Lys Ile 
    210                 215                 220                 


Leu Asp Arg Asn Ile Lys Arg Glu Glu Lys Ser Leu Lys Glu Lys Gly 
225                 230                 235                 240 


Gln Ile Ile Phe Lys Ala Lys Arg Leu Met Leu Asp Lys Ser Ile Arg 
                245                 250                 255     


Phe Val Gly Asp Arg Lys Val Leu Phe Thr Ile Ser Lys Thr Leu Pro 
            260                 265                 270         


Lys Glu Tyr Glu Leu Asp Leu Pro Ser Lys Glu Lys Arg Leu Asn Trp 
        275                 280                 285             


Leu Lys Glu Lys Ile Glu Ile Ile Lys Asn Gln Lys Pro Lys Tyr Ala 
    290                 295                 300                 


Tyr Leu Leu Arg Lys Asn Ile Glu Ser Glu Lys Lys Pro Asn Tyr Glu 
305                 310                 315                 320 


Tyr Tyr Leu Gln Tyr Thr Leu Glu Ile Lys Pro Glu Leu Lys Asp Phe 
                325                 330                 335     


Tyr Asp Gly Ala Ile Gly Ile Asp Arg Gly Ile Asn His Ile Ala Val 
            340                 345                 350         


Cys Thr Phe Ile Ser Asn Asp Gly Lys Val Thr Pro Pro Lys Phe Phe 
        355                 360                 365             


Ser Ser Gly Glu Ile Leu Arg Leu Lys Asn Leu Gln Lys Glu Arg Asp 
    370                 375                 380                 


Arg Phe Leu Leu Arg Lys His Asn Lys Asn Arg Lys Lys Gly Asn Met 
385                 390                 395                 400 


Arg Val Ile Glu Asn Lys Ile Asn Leu Ile Leu His Arg Tyr Ser Lys 
                405                 410                 415     


Gln Ile Val Asp Met Ala Lys Lys Leu Asn Ala Ser Ile Val Phe Glu 
            420                 425                 430         


Glu Leu Gly Arg Ile Gly Lys Ser Arg Thr Lys Met Lys Lys Ser Gln 
        435                 440                 445             


Arg Tyr Lys Leu Ser Leu Phe Ile Phe Lys Lys Leu Ser Asp Leu Val 
    450                 455                 460                 


Asp Tyr Lys Ser Arg Arg Glu Gly Ile Arg Val Thr Tyr Val Pro Pro 
465                 470                 475                 480 


Glu Tyr Thr Ser Lys Glu Cys Ser His Cys Gly Glu Lys Val Asn Thr 
                485                 490                 495     


Gln Arg Pro Phe Asn Gly Asn Tyr Ser Leu Phe Lys Cys Asn Lys Cys 
            500                 505                 510         


Gly Ile Gln Leu Asn Ser Asp Tyr Asn Ala Ser Ile Asn Ile Ala Lys 
        515                 520                 525             


Lys Gly Leu Lys Ile Pro Asn Ser Thr 
    530                 535         


<210>  278
<211>  534
<212>  PRT
<213>  Unknown

<220>
<223>  uncultured archaeon

<400>  278

Met Lys Leu Ser Glu Gln Glu Asn Ile Thr Thr Gly Val Lys Phe Lys 
1               5                   10                  15      


Leu Lys Leu Asp Lys Glu Thr Ser Glu Gly Leu Asn Asp Tyr Phe Asp 
            20                  25                  30          


Glu Tyr Gly Lys Ala Ile Asn Phe Ala Ile Lys Val Ile Gln Lys Glu 
        35                  40                  45              


Leu Ala Glu Asp Arg Phe Ala Gly Lys Val Arg Leu Asp Glu Asn Lys 
    50                  55                  60                  


Lys Pro Leu Leu Asn Glu Asp Gly Lys Lys Ile Trp Asp Phe Pro Asn 
65                  70                  75                  80  


Glu Phe Cys Ser Cys Gly Lys Gln Val Asn Arg Tyr Val Asn Gly Lys 
                85                  90                  95      


Ser Leu Cys Gln Glu Cys Tyr Lys Asn Lys Phe Thr Glu Tyr Gly Ile 
            100                 105                 110         


Arg Lys Arg Met Tyr Ser Ala Lys Gly Arg Lys Ala Glu Gln Asp Ile 
        115                 120                 125             


Asn Ile Lys Asn Ser Thr Asn Lys Ile Ser Lys Thr His Phe Asn Tyr 
    130                 135                 140                 


Ala Ile Arg Glu Ala Phe Ile Leu Asp Lys Ser Ile Lys Lys Gln Arg 
145                 150                 155                 160 


Lys Glu Arg Phe Arg Arg Leu Arg Glu Met Lys Lys Lys Leu Gln Glu 
                165                 170                 175     


Phe Ile Glu Ile Arg Asp Gly Asn Lys Ile Leu Cys Pro Lys Ile Glu 
            180                 185                 190         


Lys Gln Arg Val Glu Arg Tyr Ile His Pro Ser Trp Ile Asn Lys Glu 
        195                 200                 205             


Lys Lys Leu Glu Asp Phe Arg Gly Tyr Ser Met Ser Asn Val Leu Gly 
    210                 215                 220                 


Lys Ile Lys Ile Leu Asp Arg Asn Ile Lys Arg Glu Glu Lys Ser Leu 
225                 230                 235                 240 


Lys Glu Lys Gly Gln Ile Asn Phe Lys Ala Arg Arg Leu Met Leu Asp 
                245                 250                 255     


Lys Ser Val Lys Phe Leu Asn Asp Asn Lys Ile Ser Phe Thr Ile Ser 
            260                 265                 270         


Lys Asn Leu Pro Lys Glu Tyr Glu Leu Asp Leu Pro Glu Lys Glu Lys 
        275                 280                 285             


Arg Leu Asn Trp Leu Lys Glu Lys Ile Lys Ile Ile Lys Asn Gln Lys 
    290                 295                 300                 


Pro Lys Tyr Ala Tyr Leu Leu Arg Lys Asp Asp Asn Phe Tyr Leu Gln 
305                 310                 315                 320 


Tyr Thr Leu Glu Thr Glu Phe Asn Leu Lys Glu Asp Tyr Ser Gly Ile 
                325                 330                 335     


Val Gly Ile Asp Arg Gly Val Ser His Ile Ala Val Tyr Thr Phe Val 
            340                 345                 350         


His Asn Asn Gly Lys Asn Glu Arg Pro Leu Phe Leu Asn Ser Ser Glu 
        355                 360                 365             


Ile Leu Arg Leu Lys Asn Leu Gln Lys Glu Arg Asp Arg Phe Leu Arg 
    370                 375                 380                 


Arg Lys His Asn Lys Lys Arg Lys Lys Ser Asn Met Arg Asn Ile Glu 
385                 390                 395                 400 


Lys Lys Ile Gln Leu Ile Leu His Asn Tyr Ser Lys Gln Ile Val Asp 
                405                 410                 415     


Phe Ala Lys Asn Lys Asn Ala Phe Ile Val Phe Glu Lys Leu Glu Lys 
            420                 425                 430         


Pro Lys Lys Asn Arg Ser Lys Met Ser Lys Lys Ser Gln Tyr Lys Leu 
        435                 440                 445             


Ser Gln Phe Thr Phe Lys Lys Leu Ser Asp Leu Val Asp Tyr Lys Ala 
    450                 455                 460                 


Lys Arg Glu Gly Ile Lys Val Leu Tyr Ile Ser Pro Glu Tyr Thr Ser 
465                 470                 475                 480 


Lys Glu Cys Ser His Cys Gly Glu Lys Val Asn Thr Gln Arg Pro Phe 
                485                 490                 495     


Asn Gly Asn Ser Ser Leu Phe Lys Cys Asn Lys Cys Gly Val Glu Leu 
            500                 505                 510         


Asn Ala Asp Tyr Asn Ala Ser Ile Asn Ile Ala Lys Lys Gly Leu Asn 
        515                 520                 525             


Ile Leu Asn Ser Thr Asn 
    530                 


<210>  279
<211>  726
<212>  PRT
<213>  Unknown

<220>
<223>  uncultured archaeon

<400>  279

Met Glu Arg Gln Lys Val Pro Gln Ile Arg Lys Ile Val Arg Val Val 
1               5                   10                  15      


Pro Leu Arg Ile Leu Arg Pro Lys Tyr Ser Asp Val Ile Glu Asn Ala 
            20                  25                  30          


Leu Lys Lys Phe Lys Glu Lys Gly Asp Asp Thr Asn Thr Asn Asp Phe 
        35                  40                  45              


Trp Arg Ala Ile Arg Asp Arg Asp Thr Glu Phe Phe Arg Lys Glu Leu 
    50                  55                  60                  


Asn Phe Ser Glu Asp Glu Ile Asn Gln Leu Glu Arg Asp Thr Leu Phe 
65                  70                  75                  80  


Arg Val Gly Leu Asp Asn Arg Val Leu Phe Ser Tyr Phe Asp Phe Leu 
                85                  90                  95      


Gln Glu Lys Leu Met Lys Asp Tyr Asn Lys Ile Ile Ser Lys Leu Phe 
            100                 105                 110         


Ile Asn Arg Gln Ser Lys Ser Ser Phe Glu Asn Asp Leu Thr Asp Glu 
        115                 120                 125             


Glu Val Glu Glu Leu Ile Glu Lys Asp Val Thr Pro Phe Tyr Gly Ala 
    130                 135                 140                 


Tyr Ile Gly Lys Gly Ile Lys Ser Val Ile Lys Ser Asn Leu Gly Gly 
145                 150                 155                 160 


Lys Phe Ile Lys Ser Val Lys Ile Asp Arg Glu Thr Lys Lys Val Thr 
                165                 170                 175     


Lys Leu Thr Ala Ile Asn Ile Gly Leu Met Gly Leu Pro Val Ala Lys 
            180                 185                 190         


Ser Asp Thr Phe Pro Ile Lys Ile Ile Lys Thr Asn Pro Asp Tyr Ile 
        195                 200                 205             


Thr Phe Gln Lys Ser Thr Lys Glu Asn Leu Gln Lys Ile Glu Asp Tyr 
    210                 215                 220                 


Glu Thr Gly Ile Glu Tyr Gly Asp Leu Leu Val Gln Ile Thr Ile Pro 
225                 230                 235                 240 


Trp Phe Lys Asn Glu Asn Lys Asp Phe Ser Leu Ile Lys Thr Lys Glu 
                245                 250                 255     


Ala Ile Glu Tyr Tyr Lys Leu Asn Gly Val Gly Lys Lys Asp Leu Leu 
            260                 265                 270         


Asn Ile Asn Leu Val Leu Thr Thr Tyr His Ile Arg Lys Lys Lys Ser 
        275                 280                 285             


Trp Gln Ile Asp Gly Ser Ser Gln Ser Leu Val Arg Glu Met Ala Asn 
    290                 295                 300                 


Gly Glu Leu Glu Glu Lys Trp Lys Ser Phe Phe Asp Thr Phe Ile Lys 
305                 310                 315                 320 


Lys Tyr Gly Asp Glu Gly Lys Ser Ala Leu Val Lys Arg Arg Val Asn 
                325                 330                 335     


Lys Lys Ser Arg Ala Lys Gly Glu Lys Gly Arg Glu Leu Asn Leu Asp 
            340                 345                 350         


Glu Arg Ile Lys Arg Leu Tyr Asp Ser Ile Lys Ala Lys Ser Phe Pro 
        355                 360                 365             


Ser Glu Ile Asn Leu Ile Pro Glu Asn Tyr Lys Trp Lys Leu His Phe 
    370                 375                 380                 


Ser Ile Glu Ile Pro Pro Met Val Asn Asp Ile Asp Ser Asn Leu Tyr 
385                 390                 395                 400 


Gly Gly Ile Asp Phe Gly Glu Gln Asn Ile Ala Thr Leu Cys Val Lys 
                405                 410                 415     


Asn Ile Glu Lys Asp Asp Tyr Asp Phe Leu Thr Ile Tyr Gly Asn Asp 
            420                 425                 430         


Leu Leu Lys His Ala Gln Ala Ser Tyr Ala Arg Arg Arg Ile Met Arg 
        435                 440                 445             


Val Gln Asp Glu Tyr Lys Ala Arg Gly His Gly Lys Ser Arg Lys Thr 
    450                 455                 460                 


Lys Ala Gln Glu Asp Tyr Ser Glu Arg Met Gln Lys Leu Arg Gln Lys 
465                 470                 475                 480 


Ile Thr Glu Arg Leu Val Lys Gln Ile Ser Asp Phe Phe Leu Trp Arg 
                485                 490                 495     


Asn Lys Phe His Met Ala Val Cys Ser Leu Arg Tyr Glu Asp Leu Asn 
            500                 505                 510         


Thr Leu Tyr Lys Gly Glu Ser Val Lys Ala Lys Arg Met Arg Gln Phe 
        515                 520                 525             


Ile Asn Lys Gln Gln Leu Phe Asn Gly Ile Glu Arg Lys Leu Lys Asp 
    530                 535                 540                 


Tyr Asn Ser Glu Ile Tyr Val Asn Ser Arg Tyr Pro His Tyr Thr Ser 
545                 550                 555                 560 


Arg Leu Cys Ser Lys Cys Gly Lys Leu Asn Leu Tyr Phe Asp Phe Leu 
                565                 570                 575     


Lys Phe Arg Thr Lys Asn Ile Ile Ile Arg Lys Asn Pro Asp Gly Ser 
            580                 585                 590         


Glu Ile Lys Tyr Met Pro Phe Phe Ile Cys Glu Phe Cys Gly Trp Lys 
        595                 600                 605             


Gln Ala Gly Asp Lys Asn Ala Ser Ala Asn Ile Ala Asp Lys Asp Tyr 
    610                 615                 620                 


Gln Asp Lys Leu Asn Lys Glu Lys Glu Phe Cys Asn Ile Arg Lys Pro 
625                 630                 635                 640 


Lys Ser Lys Lys Glu Asp Ile Gly Glu Glu Asn Glu Glu Glu Arg Asp 
                645                 650                 655     


Tyr Ser Arg Arg Phe Asn Arg Asn Ser Phe Ile Tyr Asn Ser Leu Lys 
            660                 665                 670         


Lys Asp Asn Lys Leu Asn Gln Glu Lys Leu Phe Asp Glu Trp Lys Asn 
        675                 680                 685             


Gln Leu Lys Arg Lys Ile Asp Gly Arg Asn Lys Phe Glu Pro Lys Glu 
    690                 695                 700                 


Tyr Lys Asp Arg Phe Ser Tyr Leu Phe Ala Tyr Tyr Gln Glu Ile Ile 
705                 710                 715                 720 


Lys Asn Glu Ser Glu Ser 
                725     


<210>  280
<211>  777
<212>  PRT
<213>  Unknown

<220>
<223>  uncultured archaeon

<400>  280

Met Val Thr Arg Ala Ile Lys Leu Lys Leu Asp Pro Thr Lys Asn Gln 
1               5                   10                  15      


Tyr Lys Leu Leu Asn Glu Met Phe Trp Lys Trp Ala Ser Leu Ala Asn 
            20                  25                  30          


Arg Phe Ser Gln Lys Gly Ala Ser Lys Glu Thr Leu Ala Pro Lys Asp 
        35                  40                  45              


Gly Thr Gln Lys Ile Gln Phe Asn Ala Thr Gln Leu Asn Gln Ile Lys 
    50                  55                  60                  


Lys Asp Val Asp Asp Leu Arg Gly Ala Met Glu Lys Gln Gly Lys Gln 
65                  70                  75                  80  


Lys Glu Arg Leu Leu Ile Gln Ile Gln Glu Arg Leu Leu Thr Ile Ser 
                85                  90                  95      


Glu Ile Leu Arg Asp Asp Ser Lys Lys Glu Lys Asp Pro His Arg Pro 
            100                 105                 110         


Gln Asn Phe Arg Pro Phe Gly Trp Arg Arg Phe His Thr Ser Ala Tyr 
        115                 120                 125             


Trp Ser Ser Glu Ala Ser Lys Leu Thr Arg Gln Val Asp Arg Val Arg 
    130                 135                 140                 


Arg Thr Ile Glu Arg Ile Lys Ala Gly Lys Ile Asn Phe Lys Pro Lys 
145                 150                 155                 160 


Arg Ile Gly Leu Trp Ser Ser Thr Tyr Lys Ile Asn Phe Leu Lys Lys 
                165                 170                 175     


Lys Ile Asn Ile Ser Pro Leu Lys Ser Lys Ser Phe Glu Leu Asp Leu 
            180                 185                 190         


Ile Thr Glu Pro Gln Gln Lys Ile Ile Gly Lys Glu Gly Gly Lys Ser 
        195                 200                 205             


Val Ala Asn Ser Lys Lys Tyr Leu Asp Asp Ser Ile Lys Ser Leu Leu 
    210                 215                 220                 


Ile Phe Ala Ile Lys Ser Arg Leu Phe Gly Leu Asn Asn Lys Asp Lys 
225                 230                 235                 240 


Pro Leu Phe Glu Asn Ile Ile Thr Pro Asn Leu Val Arg Tyr His Lys 
                245                 250                 255     


Lys Gly Gln Glu Gln Glu Asn Phe Lys Lys Glu Val Ile Lys Lys Phe 
            260                 265                 270         


Glu Asn Lys Leu Lys Lys Glu Ile Ser Gln Lys Gln Lys Glu Ile Ile 
        275                 280                 285             


Phe Ser Gln Ile Glu Arg Gln Tyr Glu Asn Arg Asp Ala Thr Phe Ser 
    290                 295                 300                 


Glu Asp Tyr Leu Arg Ala Ile Ser Glu Phe Ser Glu Ile Phe Asn Gln 
305                 310                 315                 320 


Arg Lys Lys Glu Arg Ala Lys Glu Leu Leu Asn Ser Phe Asn Glu Lys 
                325                 330                 335     


Ile Arg Gln Leu Lys Lys Glu Val Asn Gly Asn Ile Ser Glu Glu Asp 
            340                 345                 350         


Leu Lys Ile Leu Glu Val Glu Ala Glu Lys Ala Tyr Asn Tyr Glu Asn 
        355                 360                 365             


Gly Phe Ile Glu Trp Glu Tyr Ser Glu Gln Phe Leu Gly Val Leu Glu 
    370                 375                 380                 


Lys Ile Ala Arg Ala Val Leu Ile Ser Asp Asn Tyr Phe Asp Leu Lys 
385                 390                 395                 400 


Lys Tyr Pro Ile Leu Ile Arg Lys Pro Thr Asn Lys Ser Lys Lys Ile 
                405                 410                 415     


Thr Asn Leu Lys Pro Glu Glu Trp Asp Tyr Tyr Ile Gln Phe Gly Tyr 
            420                 425                 430         


Gly Leu Ile Asn Ser Pro Met Lys Ile Glu Thr Lys Asn Phe Met Gly 
        435                 440                 445             


Ile Asp Arg Gly Leu Thr His Leu Leu Ala Tyr Ser Ile Phe Asp Arg 
    450                 455                 460                 


Asp Ser Glu Lys Phe Thr Ile Asn Gln Leu Glu Leu Asn Pro Ile Lys 
465                 470                 475                 480 


Gly Trp Lys Trp Lys Leu Arg Lys Val Lys Arg Ser Leu Gln His Leu 
                485                 490                 495     


Glu Arg Arg Met Arg Ala Gln Lys Gly Val Lys Leu Pro Glu Asn Gln 
            500                 505                 510         


Met Lys Lys Arg Leu Lys Ser Ile Glu Pro Lys Ile Glu Ser Tyr Tyr 
        515                 520                 525             


His Asn Leu Ser Arg Lys Ile Val Asn Leu Ala Lys Ala Asn Asn Ala 
    530                 535                 540                 


Ser Ile Val Val Glu Ser Leu Glu Gly Gly Gly Leu Lys Gln His Gly 
545                 550                 555                 560 


Arg Lys Lys Asn Ser Arg His Arg Ala Leu Asn Tyr Ala Leu Ser Leu 
                565                 570                 575     


Phe Asp Tyr Gly Lys Ile Ala Ser Leu Ile Lys Tyr Lys Ser Asp Leu 
            580                 585                 590         


Glu Gly Val Pro Met Tyr Glu Val Leu Pro Ala Tyr Thr Ser Gln Gln 
        595                 600                 605             


Cys Ala Lys Cys Val Leu Lys Lys Gly Ser Phe Val Glu Pro Glu Ile 
    610                 615                 620                 


Ile Gly Tyr Ile Glu Glu Ile Gly Phe Lys Glu Asn Leu Leu Thr Leu 
625                 630                 635                 640 


Leu Phe Glu Asp Thr Gly Leu Ser Ser Val Gln Val Leu Lys Lys Ser 
                645                 650                 655     


Lys Asn Lys Met Thr Leu Ser Ala Arg Asp Lys Glu Gly Lys Met Val 
            660                 665                 670         


Asp Leu Val Leu Lys Tyr Asn Phe Lys Gly Leu Val Ile Ser Gln Glu 
        675                 680                 685             


Lys Lys Lys Glu Glu Ile Val Glu Phe Pro Ile Lys Glu Ile Asp Gly 
    690                 695                 700                 


Lys Phe Ala Val Leu Asp Ser Ala Tyr Lys Arg Gly Lys Glu Arg Ile 
705                 710                 715                 720 


Ser Lys Lys Gly Asn Gln Lys Leu Val Tyr Thr Gly Asn Lys Lys Val 
                725                 730                 735     


Gly Tyr Cys Ser Val His Gly Gln Val Asp Ala Asp Leu Asn Ala Ser 
            740                 745                 750         


Arg Val Ile Ala Leu Cys Lys Tyr Leu Gly Ile Asn Glu Pro Ile Val 
        755                 760                 765             


Phe Gly Glu Gln Arg Lys Ser Phe Lys 
    770                 775         


<210>  281
<211>  610
<212>  PRT
<213>  Unknown

<220>
<223>  uncultured archaeon

<400>  281

Met Asp Leu Ile Thr Glu Pro Ile Gln Pro His Lys Ser Ser Ser Leu 
1               5                   10                  15      


Arg Ser Lys Glu Phe Leu Glu Tyr Gln Ile Ser Asp Phe Leu Asn Phe 
            20                  25                  30          


Ser Leu His Ser Leu Phe Phe Gly Leu Ala Ser Asn Glu Gly Pro Leu 
        35                  40                  45              


Val Asp Phe Lys Ile Tyr Asp Lys Ile Val Ile Pro Lys Pro Glu Glu 
    50                  55                  60                  


Arg Phe Pro Lys Lys Glu Ser Glu Glu Gly Lys Lys Leu Asp Ser Phe 
65                  70                  75                  80  


Asp Lys Arg Val Glu Glu Tyr Tyr Ser Asp Lys Leu Glu Lys Lys Ile 
                85                  90                  95      


Glu Arg Lys Leu Asn Thr Glu Glu Lys Asn Val Ile Asp Arg Glu Lys 
            100                 105                 110         


Thr Arg Ile Trp Gly Glu Val Asn Lys Leu Glu Glu Ile Arg Ser Ile 
        115                 120                 125             


Ile Asp Glu Ile Asn Glu Ile Lys Lys Gln Lys His Ile Ser Glu Lys 
    130                 135                 140                 


Ser Lys Leu Leu Gly Glu Lys Trp Lys Lys Val Asn Asn Ile Gln Glu 
145                 150                 155                 160 


Thr Leu Leu Ser Gln Glu Tyr Val Ser Leu Ile Ser Asn Leu Ser Asp 
                165                 170                 175     


Glu Leu Thr Asn Lys Lys Lys Glu Leu Leu Ala Lys Lys Tyr Ser Lys 
            180                 185                 190         


Phe Asp Asp Lys Ile Lys Lys Ile Lys Glu Asp Tyr Gly Leu Glu Phe 
        195                 200                 205             


Asp Glu Asn Thr Ile Lys Lys Glu Gly Glu Lys Ala Phe Leu Asn Pro 
    210                 215                 220                 


Asp Lys Phe Ser Lys Tyr Gln Phe Ser Ser Ser Tyr Leu Lys Leu Ile 
225                 230                 235                 240 


Gly Glu Ile Ala Arg Ser Leu Ile Thr Tyr Lys Gly Phe Leu Asp Leu 
                245                 250                 255     


Asn Lys Tyr Pro Ile Ile Phe Arg Lys Pro Ile Asn Lys Val Lys Lys 
            260                 265                 270         


Ile His Asn Leu Glu Pro Asp Glu Trp Lys Tyr Tyr Ile Gln Phe Gly 
        275                 280                 285             


Tyr Glu Gln Ile Asn Asn Pro Lys Leu Glu Thr Glu Asn Ile Leu Gly 
    290                 295                 300                 


Ile Asp Arg Gly Leu Thr His Ile Leu Ala Tyr Ser Val Phe Glu Pro 
305                 310                 315                 320 


Arg Ser Ser Lys Phe Ile Leu Asn Lys Leu Glu Pro Asn Pro Ile Glu 
                325                 330                 335     


Gly Trp Lys Trp Lys Leu Arg Lys Leu Arg Arg Ser Ile Gln Asn Leu 
            340                 345                 350         


Glu Arg Arg Trp Arg Ala Gln Asp Asn Val Lys Leu Pro Glu Asn Gln 
        355                 360                 365             


Met Lys Lys Asn Leu Arg Ser Ile Glu Asp Lys Val Glu Asn Leu Tyr 
    370                 375                 380                 


His Asn Leu Ser Arg Lys Ile Val Asp Leu Ala Lys Glu Lys Asn Ala 
385                 390                 395                 400 


Cys Ile Val Phe Glu Lys Leu Glu Gly Gln Gly Met Lys Gln His Gly 
                405                 410                 415     


Arg Lys Lys Ser Asp Arg Leu Arg Gly Leu Asn Tyr Lys Leu Ser Leu 
            420                 425                 430         


Phe Asp Tyr Gly Lys Ile Ala Lys Leu Ile Lys Tyr Lys Ala Glu Ile 
        435                 440                 445             


Glu Gly Ile Pro Ile Tyr Arg Ile Asp Ser Ala Tyr Thr Ser Gln Asn 
    450                 455                 460                 


Cys Ala Lys Cys Val Leu Glu Ser Arg Arg Phe Ala Gln Pro Glu Glu 
465                 470                 475                 480 


Ile Ser Cys Leu Asp Asp Phe Lys Glu Gly Asp Asn Leu Asp Lys Arg 
                485                 490                 495     


Ile Leu Glu Gly Thr Gly Leu Val Glu Ala Lys Ile Tyr Lys Lys Leu 
            500                 505                 510         


Leu Lys Glu Lys Lys Glu Asp Phe Glu Ile Glu Glu Asp Ile Ala Met 
        515                 520                 525             


Phe Asp Thr Lys Lys Val Ile Lys Glu Asn Lys Glu Lys Thr Val Ile 
    530                 535                 540                 


Leu Asp Tyr Val Tyr Thr Arg Arg Lys Glu Ile Ile Gly Thr Asn His 
545                 550                 555                 560 


Lys Lys Asn Ile Lys Gly Ile Ala Lys Tyr Thr Gly Asn Thr Lys Ile 
                565                 570                 575     


Gly Tyr Cys Met Lys His Gly Gln Val Asp Ala Asp Leu Asn Ala Ser 
            580                 585                 590         


Arg Thr Ile Ala Leu Cys Lys Asn Phe Asp Ile Asn Asn Pro Glu Ile 
        595                 600                 605             


Trp Lys 
    610 


<210>  282
<211>  564
<212>  PRT
<213>  Unknown

<220>
<223>  uncultured archaeon

<400>  282

Met Ala Arg Ala Lys Asn Gln Pro Tyr Gln Lys Leu Thr Thr Thr Thr 
1               5                   10                  15      


Gly Ile Lys Phe Lys Leu Asp Leu Ser Glu Glu Glu Gly Lys Arg Phe 
            20                  25                  30          


Asp Glu Tyr Phe Ser Glu Tyr Ala Lys Ala Val Asn Phe Cys Ala Lys 
        35                  40                  45              


Val Ile Tyr Gln Leu Arg Lys Asn Leu Lys Phe Ala Gly Lys Lys Glu 
    50                  55                  60                  


Leu Ala Ala Lys Glu Trp Lys Phe Glu Ile Ser Asn Cys Asp Phe Cys 
65                  70                  75                  80  


Asn Lys Gln Lys Glu Ile Tyr Tyr Lys Asn Ile Ala Asn Gly Gln Lys 
                85                  90                  95      


Val Cys Lys Gly Cys His Arg Thr Asn Phe Ser Asp Asn Ala Ile Arg 
            100                 105                 110         


Lys Lys Met Ile Pro Val Lys Gly Arg Lys Val Glu Ser Lys Phe Asn 
        115                 120                 125             


Ile His Asn Thr Thr Lys Lys Ile Ser Gly Thr His Arg His Trp Ala 
    130                 135                 140                 


Phe Glu Asp Ala Ala Asp Ile Ile Glu Ser Met Asp Lys Gln Arg Lys 
145                 150                 155                 160 


Glu Lys Gln Lys Arg Leu Arg Arg Glu Lys Arg Lys Leu Ser Tyr Phe 
                165                 170                 175     


Phe Glu Leu Phe Gly Asp Pro Ala Lys Arg Tyr Glu Leu Pro Lys Val 
            180                 185                 190         


Gly Lys Gln Arg Val Pro Arg Tyr Leu His Lys Ile Ile Asp Lys Asp 
        195                 200                 205             


Ser Leu Thr Lys Lys Arg Gly Tyr Ser Leu Ser Tyr Ile Lys Asn Lys 
    210                 215                 220                 


Ile Lys Ile Ser Glu Arg Asn Ile Glu Arg Asp Glu Lys Ser Leu Arg 
225                 230                 235                 240 


Lys Ala Ser Pro Ile Ala Phe Gly Ala Arg Lys Ile Lys Met Ser Lys 
                245                 250                 255     


Leu Asp Pro Lys Arg Ala Phe Asp Leu Glu Asn Asn Val Phe Lys Ile 
            260                 265                 270         


Pro Gly Lys Val Ile Lys Gly Gln Tyr Lys Phe Phe Gly Thr Asn Val 
        275                 280                 285             


Ala Asn Glu His Gly Lys Lys Phe Tyr Lys Asp Arg Ile Ser Lys Ile 
    290                 295                 300                 


Leu Ala Gly Lys Pro Lys Tyr Phe Tyr Leu Leu Arg Lys Lys Val Ala 
305                 310                 315                 320 


Glu Ser Asp Gly Asn Pro Ile Phe Glu Tyr Tyr Val Gln Trp Ser Ile 
                325                 330                 335     


Asp Thr Glu Thr Pro Ala Ile Thr Ser Tyr Asp Asn Ile Leu Gly Ile 
            340                 345                 350         


Asp Ala Gly Ile Thr Asn Leu Ala Thr Thr Val Leu Ile Pro Lys Asn 
        355                 360                 365             


Leu Ser Ala Glu His Cys Ser His Cys Gly Asn Asn His Val Lys Pro 
    370                 375                 380                 


Ile Phe Thr Lys Phe Phe Ser Gly Lys Glu Leu Lys Ala Ile Lys Ile 
385                 390                 395                 400 


Lys Ser Arg Lys Gln Lys Tyr Phe Leu Arg Gly Lys His Asn Lys Leu 
                405                 410                 415     


Val Lys Ile Lys Arg Ile Arg Pro Ile Glu Gln Lys Val Asp Gly Tyr 
            420                 425                 430         


Cys His Val Val Ser Lys Gln Ile Val Glu Met Ala Lys Glu Arg Asn 
        435                 440                 445             


Ser Cys Ile Ala Leu Glu Lys Leu Glu Lys Pro Lys Lys Ser Lys Phe 
    450                 455                 460                 


Arg Gln Arg Arg Arg Glu Lys Tyr Ala Val Ser Met Phe Val Phe Lys 
465                 470                 475                 480 


Lys Leu Ala Thr Phe Ile Lys Tyr Lys Ala Ala Arg Glu Gly Ile Glu 
                485                 490                 495     


Ile Ile Pro Val Glu Pro Glu Gly Thr Ser Tyr Thr Cys Ser His Cys 
            500                 505                 510         


Lys Asn Ala Gln Asn Asn Gln Arg Pro Tyr Phe Lys Pro Asn Ser Lys 
        515                 520                 525             


Lys Ser Trp Thr Ser Met Phe Lys Cys Gly Lys Cys Gly Ile Glu Leu 
    530                 535                 540                 


Asn Ser Asp Tyr Asn Ala Ala Phe Asn Ile Ala Gln Lys Ala Leu Asn 
545                 550                 555                 560 


Met Thr Ser Ala 
                


<210>  283
<211>  610
<212>  PRT
<213>  Unknown

<220>
<223>  uncultured archaeon

<400>  283

Met Asp Glu Lys His Phe Phe Cys Ser Tyr Cys Asn Lys Glu Leu Lys 
1               5                   10                  15      


Ile Ser Lys Asn Leu Ile Asn Lys Ile Ser Lys Gly Ser Ile Arg Glu 
            20                  25                  30          


Asp Glu Ala Val Ser Lys Ala Ile Ser Ile His Asn Lys Lys Glu His 
        35                  40                  45              


Ser Leu Ile Leu Gly Ile Lys Phe Lys Leu Phe Ile Glu Asn Lys Leu 
    50                  55                  60                  


Asp Lys Lys Lys Leu Asn Glu Tyr Phe Asp Asn Tyr Ser Lys Ala Val 
65                  70                  75                  80  


Thr Phe Ala Ala Arg Ile Phe Asp Lys Ile Arg Ser Pro Tyr Lys Phe 
                85                  90                  95      


Ile Gly Leu Lys Asp Lys Asn Thr Lys Lys Trp Thr Phe Pro Lys Ala 
            100                 105                 110         


Lys Cys Val Phe Cys Leu Glu Glu Lys Glu Val Ala Tyr Ala Asn Glu 
        115                 120                 125             


Lys Asp Asn Ser Lys Ile Cys Thr Glu Cys Tyr Leu Lys Glu Phe Gly 
    130                 135                 140                 


Glu Asn Gly Ile Arg Lys Lys Ile Tyr Ser Thr Arg Gly Arg Lys Val 
145                 150                 155                 160 


Glu Pro Lys Tyr Asn Ile Phe Asn Ser Thr Lys Glu Leu Ser Ser Thr 
                165                 170                 175     


His Tyr Asn Tyr Ala Ile Arg Asp Ala Phe Gln Leu Leu Asp Ala Leu 
            180                 185                 190         


Lys Lys Gln Arg Gln Lys Lys Leu Lys Ser Ile Phe Asn Gln Lys Leu 
        195                 200                 205             


Arg Leu Lys Glu Phe Glu Asp Ile Phe Ser Asp Pro Gln Lys Arg Ile 
    210                 215                 220                 


Glu Leu Ser Leu Lys Pro His Gln Arg Glu Lys Arg Tyr Ile His Leu 
225                 230                 235                 240 


Ser Lys Ser Gly Gln Glu Ser Ile Asn Arg Gly Tyr Thr Leu Arg Phe 
                245                 250                 255     


Val Arg Gly Lys Ile Lys Ser Leu Thr Arg Asn Ile Glu Arg Glu Glu 
            260                 265                 270         


Lys Ser Leu Arg Lys Lys Thr Pro Ile His Phe Lys Gly Asn Arg Leu 
        275                 280                 285             


Met Ile Phe Pro Ala Gly Ile Lys Phe Asp Phe Ala Ser Asn Lys Val 
    290                 295                 300                 


Lys Ile Ser Ile Ser Lys Asn Leu Pro Asn Glu Phe Asn Phe Ser Gly 
305                 310                 315                 320 


Thr Asn Val Lys Asn Glu His Gly Lys Ser Phe Phe Lys Ser Arg Ile 
                325                 330                 335     


Glu Leu Ile Lys Thr Gln Lys Pro Lys Tyr Ala Tyr Val Leu Arg Lys 
            340                 345                 350         


Ile Lys Arg Glu Tyr Ser Lys Leu Arg Asn Tyr Glu Ile Glu Lys Ile 
        355                 360                 365             


Arg Leu Glu Asn Pro Asn Ala Asp Leu Cys Asp Phe Tyr Leu Gln Tyr 
    370                 375                 380                 


Thr Ile Glu Thr Glu Ser Arg Asn Asn Glu Glu Ile Asn Gly Ile Ile 
385                 390                 395                 400 


Gly Ile Asp Arg Gly Ile Thr Asn Leu Ala Cys Leu Val Leu Leu Lys 
                405                 410                 415     


Lys Gly Asp Lys Lys Pro Ser Gly Val Lys Phe Tyr Lys Gly Asn Lys 
            420                 425                 430         


Ile Leu Gly Met Lys Ile Ala Tyr Arg Lys His Leu Tyr Leu Leu Lys 
        435                 440                 445             


Gly Lys Arg Asn Lys Leu Arg Lys Gln Arg Gln Ile Arg Ala Ile Glu 
    450                 455                 460                 


Pro Lys Ile Asn Leu Ile Leu His Gln Ile Ser Lys Asp Ile Val Lys 
465                 470                 475                 480 


Ile Ala Lys Glu Lys Asn Phe Ala Ile Ala Leu Glu Gln Leu Glu Lys 
                485                 490                 495     


Pro Lys Lys Ala Arg Phe Ala Gln Arg Lys Lys Glu Lys Tyr Lys Leu 
            500                 505                 510         


Ala Leu Phe Thr Phe Lys Asn Leu Ser Thr Leu Ile Glu Tyr Lys Ser 
        515                 520                 525             


Lys Arg Glu Gly Ile Pro Val Ile Tyr Val Pro Pro Glu Lys Thr Ser 
    530                 535                 540                 


Gln Met Cys Ser His Cys Ala Ile Asn Gly Asp Glu His Val Asp Thr 
545                 550                 555                 560 


Gln Arg Pro Tyr Lys Lys Pro Asn Ala Gln Lys Pro Ser Tyr Ser Leu 
                565                 570                 575     


Phe Lys Cys Asn Lys Cys Gly Ile Glu Leu Asn Ala Asp Tyr Asn Ala 
            580                 585                 590         


Ala Phe Asn Ile Ala Gln Lys Gly Leu Lys Thr Leu Met Leu Asn His 
        595                 600                 605             


Ser His 
    610 


<210>  284
<211>  327
<212>  PRT
<213>  Clostridioides difficile

<400>  284

Met Val Asn Ile Gln Tyr Lys Arg Thr Leu Ser Leu Val Thr Gln Arg 
1               5                   10                  15      


Ile Lys Lys Asp Tyr Ser Asn Asp Phe Val Gly Ile Ile Thr Gly Gln 
            20                  25                  30          


Gln Ser Leu Arg Asn Tyr Arg Asn Asp Asn Pro Leu Met Ile Ser Asn 
        35                  40                  45              


Gln Gln Leu Asn Phe Lys Tyr Ile Asp Asp Thr Phe Tyr Leu Asp Ile 
    50                  55                  60                  


Met Cys Gly Tyr Arg Leu Glu Val Val Leu Gly Lys Arg Asp Asn Glu 
65                  70                  75                  80  


Asn Val Asn Glu Leu Lys Ser Thr Leu Glu Lys Val Ile Ser Lys Glu 
                85                  90                  95      


Tyr Lys Val Cys Asp Ser Ser Met Gln Phe Ser Lys Asn Asn Asn Asp 
            100                 105                 110         


Val Ile Leu Asn Leu Val Ile Asp Ile Pro Gln Asn Ser Asn Val Tyr 
        115                 120                 125             


Lys Pro Val Glu Gly Arg Thr Leu Gly Val Asp Leu Gly Val Ala Val 
    130                 135                 140                 


Pro Ile Tyr Met Cys Leu Asn Asp Asp Thr Tyr Lys Arg Lys Gly Leu 
145                 150                 155                 160 


Gly Asp Ile Asn Asn Phe Leu Arg Val Arg Gln Gln Met Gln Thr Arg 
                165                 170                 175     


Arg Arg Lys Leu Gln Lys Asp Leu Thr Leu Thr Asn Gly Gly Lys Gly 
            180                 185                 190         


Arg Lys Lys Lys Thr Gln Leu Leu Asp Lys Leu Gln Glu Asn Glu Arg 
        195                 200                 205             


Asn Phe Val Lys Thr Tyr Ser His Ala Leu Ser Lys Arg Val Val Glu 
    210                 215                 220                 


Phe Ala Lys Ser Asn Lys Cys Glu Tyr Ile Asn Ile Glu Lys Leu Thr 
225                 230                 235                 240 


Lys Asp Gly Phe Asp Asn Ile Ile Leu Arg Asn Trp Ser Tyr Phe Glu 
                245                 250                 255     


Leu Gln Lys Met Ile Glu Tyr Lys Ala Glu Arg Glu Gly Ile Thr Val 
            260                 265                 270         


Arg Tyr Val Asn Pro Ala Tyr Thr Ser Gln Lys Cys Ser Arg Cys Gly 
        275                 280                 285             


Glu Ile Asp Lys Glu Asn Arg Gln Thr Gln Ala Lys Phe Lys Cys Thr 
    290                 295                 300                 


Lys Cys Gly Phe Glu Leu Asn Ala Asp His Asn Ala Ala Ile Asn Ile 
305                 310                 315                 320 


Ala Arg Ser Ile Glu Phe Val 
                325         


<210>  285
<211>  364
<212>  PRT
<213>  Desulfovibrio fructosivorans

<400>  285

Met Ala Thr Leu Glu Arg Asn Phe Ala Val Lys Thr Tyr Arg Asn Thr 
1               5                   10                  15      


Asn Lys Asp Ala Trp Ala Gly Arg Lys Ser Leu Pro Thr Tyr Arg Ser 
            20                  25                  30          


Leu Phe Val Pro Phe Arg His Thr Gly Thr Lys Ile Ala Val Val Glu 
        35                  40                  45              


Arg Asn Gly Thr Lys Gln Phe Cys Ile Asp Pro Gln Gly Phe Gly Ala 
    50                  55                  60                  


Ser Trp Leu Ser Asp Glu Leu Ile Ala Glu Val His Asp Gly Pro Ile 
65                  70                  75                  80  


Ala Ile Glu Lys Gln Arg Arg Lys Leu Thr Leu Val Ser Cys Phe Ser 
                85                  90                  95      


Trp Arg Asp Gln Gly Ala Val Glu Ile Val Gln Arg Ile Val Asn Gly 
            100                 105                 110         


Glu Tyr Lys Leu Ser Asp Gly Gln Ile Gln Met Gly Lys Lys Gly Leu 
        115                 120                 125             


Val Ala Leu Leu Pro Tyr Ser Phe Asp Ala Ile Gln Pro Glu Leu Asp 
    130                 135                 140                 


Pro Ala Arg Val Cys Gly Ile Asp Leu Gly Ala Val Ile Pro Ala Val 
145                 150                 155                 160 


Cys Ala Val Asn Phe Gly Pro Gln Arg Ala Tyr Leu Gly Glu Gly Lys 
                165                 170                 175     


Asp Val Trp Ala Ala Arg Ser Arg Phe Arg Ala Glu Arg Arg Arg Leu 
            180                 185                 190         


Gln Ser Arg Ala Gly Leu Tyr Ser Lys Thr Lys Asn Trp Arg Arg Ser 
        195                 200                 205             


Glu Lys Glu Asp Asn Trp Ile Gln Thr Tyr Tyr His Ala Leu Thr Arg 
    210                 215                 220                 


Lys Val Ile Lys Phe Cys Val Gln His Gly Cys Gly Thr Ile His Met 
225                 230                 235                 240 


Glu Asp Leu Ser Ser Leu Arg Gln Arg Asp Val Glu Ser Glu Phe Arg 
                245                 250                 255     


Arg Leu Leu Trp Val Pro Ser Lys Phe Phe Glu Leu Leu Ser Tyr Lys 
            260                 265                 270         


Ala Lys Glu Met Gly Ile Gly Ile Val Lys Ile Asn Pro Arg Asn Thr 
        275                 280                 285             


Ser Lys Arg Cys Ser Glu Cys Gly His Ile Ser Lys Gly Asn Arg Lys 
    290                 295                 300                 


Ser Gln Glu Lys Phe Val Cys Glu Lys Cys Gly Glu Gly Lys Arg Pro 
305                 310                 315                 320 


Val Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Leu Ala Thr Gly 
                325                 330                 335     


Asp Val Leu Leu His Gly Tyr Ile Glu Ser Glu Pro Asp Ala Leu Gly 
            340                 345                 350         


Glu Met Asp Gln Leu Trp Glu Gly Ala Gln Glu Ala 
        355                 360                 


<210>  286
<211>  366
<212>  PRT
<213>  Clostridium botulinum

<400>  286

Met Asp Ile Gln Lys Glu Phe Lys Glu Lys Tyr Val Asp Asp Leu Tyr 
1               5                   10                  15      


Gln Val Leu Asp Lys Ile Pro Phe Lys His Leu Asp Asn Lys Ser Leu 
            20                  25                  30          


Val Thr Gln Arg Ile Lys Ala Asp Ile Lys Ser Asp Lys Ser Asn Gly 
        35                  40                  45              


Leu Leu Lys Gly Glu Arg Ser Ile Arg Asn Tyr Lys Arg Asn Phe Pro 
    50                  55                  60                  


Leu Met Thr Arg Gly Arg Asp Leu Lys Phe Lys Tyr Asp Asp Asn Asp 
65                  70                  75                  80  


Asp Ile Glu Ile Lys Trp Met Glu Gly Ile Lys Phe Lys Val Ile Leu 
                85                  90                  95      


Gly Asn Arg Ile Lys Asn Ser Leu Glu Leu Arg His Thr Leu His Lys 
            100                 105                 110         


Val Ile Glu Gly Lys Tyr Lys Ile Cys Asp Ser Ser Leu Gln Phe Asp 
        115                 120                 125             


Lys Asn Asn Asn Leu Ile Leu Asn Leu Thr Leu Asp Ile Pro Ile Asp 
    130                 135                 140                 


Ile Val Asn Lys Lys Val Ser Gly Arg Val Val Gly Val Asp Leu Gly 
145                 150                 155                 160 


Leu Lys Ile Pro Ala Tyr Cys Ala Leu Asn Asp Val Glu Tyr Ile Lys 
                165                 170                 175     


Lys Ser Ile Gly Arg Ile Asp Asp Phe Leu Lys Val Arg Thr Gln Met 
            180                 185                 190         


Gln Ser Arg Arg Arg Arg Leu Gln Ile Ala Ile Gln Ser Ala Lys Gly 
        195                 200                 205             


Gly Lys Gly Arg Val Asn Lys Leu Gln Ala Leu Glu Arg Phe Ala Glu 
    210                 215                 220                 


Lys Glu Lys Asn Phe Ala Lys Thr Tyr Asn His Phe Leu Ser Ser Asn 
225                 230                 235                 240 


Ile Val Lys Phe Ala Val Ser Asn Gln Ala Glu Gln Ile Asn Met Glu 
                245                 250                 255     


Leu Leu Ser Leu Lys Glu Thr Gln Asn Lys Ser Ile Leu Arg Asn Trp 
            260                 265                 270         


Ser Tyr Tyr Gln Leu Gln Thr Met Ile Glu Tyr Lys Ala Gln Arg Glu 
        275                 280                 285             


Gly Ile Lys Val Lys Tyr Ile Asp Pro Tyr His Thr Ser Gln Thr Cys 
    290                 295                 300                 


Ser Lys Cys Gly Asn Tyr Glu Glu Gly Gln Arg Glu Ser Gln Ala Asp 
305                 310                 315                 320 


Phe Ile Cys Lys Lys Cys Gly Tyr Lys Val Asn Ala Asp Tyr Asn Ala 
                325                 330                 335     


Ala Arg Asn Ile Ala Met Ser Asn Lys Tyr Ile Thr Lys Lys Lys Lys 
            340                 345                 350         


Val Ser Ile Thr Lys Leu Lys Lys Val Trp Tyr Asn Lys Thr 
        355                 360                 365     


<210>  287
<211>  401
<212>  PRT
<213>  Clostridioides difficile

<400>  287

Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val Glu Glu Glu Glu 
1               5                   10                  15      


Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln Tyr Ala Gln 
            20                  25                  30          


Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr Ser Ala Tyr Leu 
        35                  40                  45              


Ala Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys Asp Ser Gln Lys 
    50                  55                  60                  


Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile Asn Phe Gly Lys 
65                  70                  75                  80  


Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val Lys Lys Asp Phe 
                85                  90                  95      


Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu Arg Gly Phe Thr 
            100                 105                 110         


Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly Arg Asp Leu Lys 
        115                 120                 125             


Phe Tyr Glu Glu Asp Asn Glu Phe Tyr Ile Lys Trp Val Asn Lys Ile 
    130                 135                 140                 


Val Phe Lys Val Leu Ile Gly Arg Lys Asp Lys Asn Lys Val Glu Leu 
145                 150                 155                 160 


Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr Lys Val Ser Gln 
                165                 170                 175     


Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile Leu Asn Leu Thr 
            180                 185                 190         


Ile Asp Ile Pro Tyr Lys Gln Val Asp Glu Ile Val Lys Asp Arg Thr 
        195                 200                 205             


Cys Gly Val Asp Met Gly Ile Ala Ile Pro Ile Tyr Val Ala Leu Asn 
    210                 215                 220                 


Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile Asp Glu Phe Met 
225                 230                 235                 240 


Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg Leu Gln Gln Gln 
                245                 250                 255     


Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp Lys Leu Lys Gly 
            260                 265                 270         


Leu Glu Leu Leu Arg Glu Lys Glu Lys Ser Trp Val Lys Thr Tyr Asn 
        275                 280                 285             


His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys Lys Asn Lys Cys 
    290                 295                 300                 


Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly Phe Gly Asp Arg 
305                 310                 315                 320 


Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu Met Ile Lys Tyr 
                325                 330                 335     


Lys Gly Glu Arg Val Gly Ile Lys Val Lys Tyr Val Asn Pro Ala Tyr 
            340                 345                 350         


Thr Ser Gln Thr Cys Ser Glu Cys Gly His Val Asp Lys Glu Asn Arg 
        355                 360                 365             


Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly Phe Glu Ala Asn 
    370                 375                 380                 


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser Asp Lys Phe Val 
385                 390                 395                 400 


Lys 
    


<210>  288
<211>  401
<212>  PRT
<213>  Clostridioides difficile

<400>  288

Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val Glu Glu Glu Glu 
1               5                   10                  15      


Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln Tyr Ala Gln 
            20                  25                  30          


Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr Ser Ala Tyr Leu 
        35                  40                  45              


Ala Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys Asp Ser Gln Lys 
    50                  55                  60                  


Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile Asn Phe Gly Lys 
65                  70                  75                  80  


Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val Lys Lys Asp Phe 
                85                  90                  95      


Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu Arg Gly Phe Thr 
            100                 105                 110         


Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly Arg Asp Leu Lys 
        115                 120                 125             


Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp Val Asn Lys Ile 
    130                 135                 140                 


Val Phe Lys Ile Leu Ile Gly Arg Lys Asp Lys Asn Lys Val Glu Leu 
145                 150                 155                 160 


Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr Lys Val Ser Gln 
                165                 170                 175     


Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile Leu Asn Leu Thr 
            180                 185                 190         


Ile Asp Ile Pro Tyr Lys Gln Val Asp Glu Ile Val Lys Gly Arg Val 
        195                 200                 205             


Cys Gly Val Asp Met Gly Ile Ala Ile Pro Val Tyr Val Ala Leu Asn 
    210                 215                 220                 


Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile Asp Glu Phe Met 
225                 230                 235                 240 


Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg Leu Gln Gln Gln 
                245                 250                 255     


Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp Lys Leu Lys Gly 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Lys Glu Lys Ser Trp Val Lys Thr Tyr Asn 
        275                 280                 285             


His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys Lys Asn Lys Cys 
    290                 295                 300                 


Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly Phe Gly Asp Arg 
305                 310                 315                 320 


Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu Met Ile Lys Tyr 
                325                 330                 335     


Lys Ala Asp Arg Val Gly Ile Lys Val Lys His Val Asn Pro Ala Tyr 
            340                 345                 350         


Thr Ser Gln Thr Cys Ser Glu Cys Gly His Val Asp Lys Glu Asn Arg 
        355                 360                 365             


Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly Phe Glu Ala Asn 
    370                 375                 380                 


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser Asp Lys Phe Val 
385                 390                 395                 400 


Lys 
    


<210>  289
<211>  401
<212>  PRT
<213>  Clostridioides difficile

<400>  289

Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val Glu Glu Glu Glu 
1               5                   10                  15      


Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln Tyr Ala Gln 
            20                  25                  30          


Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr Ser Ala Tyr Leu 
        35                  40                  45              


Val Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys Asp Ser Gln Lys 
    50                  55                  60                  


Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile Asn Phe Gly Lys 
65                  70                  75                  80  


Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val Lys Lys Asp Phe 
                85                  90                  95      


Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu Arg Gly Phe Thr 
            100                 105                 110         


Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly Arg Asp Leu Lys 
        115                 120                 125             


Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp Val Asn Lys Ile 
    130                 135                 140                 


Val Phe Lys Ile Leu Ile Gly Arg Lys Asp Lys Asn Lys Val Glu Leu 
145                 150                 155                 160 


Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr Lys Val Ser Gln 
                165                 170                 175     


Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile Leu Asn Leu Thr 
            180                 185                 190         


Ile Asp Ile Pro Tyr Lys Lys Val Asp Glu Ile Val Lys Asp Arg Val 
        195                 200                 205             


Cys Gly Val Asp Met Gly Ile Ala Ile Pro Ile Tyr Val Ala Leu Asn 
    210                 215                 220                 


Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile Asp Glu Phe Met 
225                 230                 235                 240 


Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg Leu Gln Gln Gln 
                245                 250                 255     


Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp Lys Leu Lys Gly 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Lys Glu Lys Ser Trp Val Lys Thr Tyr Asn 
        275                 280                 285             


His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys Lys Asn Lys Cys 
    290                 295                 300                 


Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly Phe Gly Asp Arg 
305                 310                 315                 320 


Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu Met Ile Lys Tyr 
                325                 330                 335     


Lys Ala Asp Arg Val Gly Ile Lys Val Lys His Val Asn Pro Ala Tyr 
            340                 345                 350         


Thr Ser Gln Thr Cys Ser Glu Cys Gly His Ala Asp Lys Glu Asn Arg 
        355                 360                 365             


Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly Phe Glu Ala Asn 
    370                 375                 380                 


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser Asp Lys Phe Val 
385                 390                 395                 400 


Lys 
    


<210>  290
<211>  401
<212>  PRT
<213>  Clostridioides difficile

<400>  290

Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val Glu Glu Glu Glu 
1               5                   10                  15      


Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln Tyr Ala Gln 
            20                  25                  30          


Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr Ser Ala Tyr Leu 
        35                  40                  45              


Ala Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys Asp Ser Gln Lys 
    50                  55                  60                  


Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile Asn Phe Gly Lys 
65                  70                  75                  80  


Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val Lys Lys Asp Phe 
                85                  90                  95      


Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu Arg Gly Phe Thr 
            100                 105                 110         


Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly Arg Asp Leu Lys 
        115                 120                 125             


Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp Val Asn Lys Ile 
    130                 135                 140                 


Val Phe Lys Ile Leu Ile Gly Arg Lys Asp Lys Asn Lys Val Glu Leu 
145                 150                 155                 160 


Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr Lys Val Ser Gln 
                165                 170                 175     


Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile Leu Asn Leu Thr 
            180                 185                 190         


Ile Asp Ile Pro Tyr Lys Gln Val Asp Glu Ile Val Lys Gly Arg Val 
        195                 200                 205             


Cys Gly Val Asp Met Gly Ile Ala Ile Pro Val Tyr Val Ala Leu Asn 
    210                 215                 220                 


Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile Asp Glu Phe Met 
225                 230                 235                 240 


Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg Leu Gln Gln Gln 
                245                 250                 255     


Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp Lys Leu Lys Gly 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Lys Glu Lys Ser Trp Val Lys Thr Tyr Asn 
        275                 280                 285             


His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys Lys Asn Lys Cys 
    290                 295                 300                 


Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly Phe Gly Asp Arg 
305                 310                 315                 320 


Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu Met Ile Lys Tyr 
                325                 330                 335     


Lys Ala Asp Arg Val Gly Ile Lys Val Lys His Val Asn Pro Ser Tyr 
            340                 345                 350         


Thr Ser Gln Thr Cys Ser Glu Cys Gly His Val Asp Lys Glu Asn Arg 
        355                 360                 365             


Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly Phe Glu Ala Asn 
    370                 375                 380                 


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser Asp Lys Phe Val 
385                 390                 395                 400 


Lys 
    


<210>  291
<211>  401
<212>  PRT
<213>  Clostridioides difficile

<400>  291

Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val Glu Glu Glu Glu 
1               5                   10                  15      


Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln Tyr Ala Gln 
            20                  25                  30          


Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr Ser Ala Tyr Leu 
        35                  40                  45              


Ala Ser Gly Arg Asp Ile Lys Ser Asn Leu Phe Lys Asp Ser Gln Lys 
    50                  55                  60                  


Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile Asn Phe Gly Lys 
65                  70                  75                  80  


Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val Lys Lys Asp Phe 
                85                  90                  95      


Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu Arg Gly Phe Thr 
            100                 105                 110         


Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly Arg Asp Leu Lys 
        115                 120                 125             


Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp Val Asn Lys Ile 
    130                 135                 140                 


Val Phe Lys Ile Leu Ile Gly Arg Lys Asp Lys Asn Lys Val Glu Leu 
145                 150                 155                 160 


Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr Lys Val Ser Gln 
                165                 170                 175     


Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile Leu Asn Leu Thr 
            180                 185                 190         


Ile Asp Ile Pro Tyr Lys Lys Val Asp Glu Ile Val Lys Asp Arg Val 
        195                 200                 205             


Cys Gly Val Asp Met Gly Ile Ala Ile Pro Ile Tyr Val Ala Leu Asn 
    210                 215                 220                 


Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile Asp Glu Phe Met 
225                 230                 235                 240 


Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg Leu Gln Gln Gln 
                245                 250                 255     


Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp Lys Leu Lys Gly 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Lys Glu Lys Ser Trp Val Lys Thr Tyr Asn 
        275                 280                 285             


His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys Lys Asn Lys Cys 
    290                 295                 300                 


Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly Phe Gly Asp Arg 
305                 310                 315                 320 


Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu Met Ile Lys Tyr 
                325                 330                 335     


Lys Ser Asp Arg Val Gly Ile Lys Val Lys Tyr Val Asn Pro Ala Tyr 
            340                 345                 350         


Thr Ser Gln Thr Cys Ser Glu Cys Ser His Val Asp Lys Glu Asn Arg 
        355                 360                 365             


Glu Thr Gln Ser Lys Phe Lys Cys Leu Glu Cys Gly Phe Glu Ala Asn 
    370                 375                 380                 


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser Asp Lys Phe Val 
385                 390                 395                 400 


Lys 
    


<210>  292
<211>  404
<212>  PRT
<213>  Clostridioides difficile

<400>  292

Met Val Ala Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val Glu 
1               5                   10                  15      


Glu Glu Glu Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln 
            20                  25                  30          


Tyr Ala Gln Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr Ser 
        35                  40                  45              


Ala Tyr Leu Ala Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys Asp 
    50                  55                  60                  


Ser Gln Lys Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile Asn 
65                  70                  75                  80  


Phe Gly Lys Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val Lys 
                85                  90                  95      


Lys Asp Phe Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu Arg 
            100                 105                 110         


Gly Phe Thr Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly Arg 
        115                 120                 125             


Asp Leu Lys Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp Val 
    130                 135                 140                 


Asn Lys Ile Val Phe Lys Ile Leu Ile Gly Arg Lys Asp Lys Asn Lys 
145                 150                 155                 160 


Val Glu Leu Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr Lys 
                165                 170                 175     


Val Ser Gln Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile Leu 
            180                 185                 190         


Asn Leu Thr Ile Asp Ile Pro Tyr Lys Gln Val Asp Glu Ile Val Lys 
        195                 200                 205             


Gly Arg Val Cys Gly Val Asp Met Gly Ile Ala Ile Pro Val Tyr Val 
    210                 215                 220                 


Ala Leu Asn Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile Asp 
225                 230                 235                 240 


Glu Phe Met Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg Leu 
                245                 250                 255     


Gln Gln Gln Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp Lys 
            260                 265                 270         


Leu Lys Gly Leu Glu Ser Leu Arg Glu Lys Glu Lys Ser Trp Val Lys 
        275                 280                 285             


Thr Tyr Asn His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys Lys 
    290                 295                 300                 


Asn Lys Cys Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly Phe 
305                 310                 315                 320 


Gly Asp Arg Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu Met 
                325                 330                 335     


Ile Lys Tyr Lys Ala Asp Arg Val Gly Ile Lys Val Lys His Val Asn 
            340                 345                 350         


Pro Ala Tyr Thr Ser Gln Thr Cys Ser Glu Cys Gly His Val Asp Lys 
        355                 360                 365             


Glu Asn Arg Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly Phe 
    370                 375                 380                 


Glu Ala Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser Asp 
385                 390                 395                 400 


Lys Phe Val Lys 
                


<210>  293
<211>  404
<212>  PRT
<213>  Clostridioides difficile

<400>  293

Met Val Ala Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val Glu 
1               5                   10                  15      


Glu Glu Glu Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln 
            20                  25                  30          


Tyr Ala Gln Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr Ser 
        35                  40                  45              


Ala Tyr Leu Val Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys Asp 
    50                  55                  60                  


Ser Gln Lys Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile Asn 
65                  70                  75                  80  


Phe Gly Lys Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val Lys 
                85                  90                  95      


Lys Asp Phe Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu Arg 
            100                 105                 110         


Gly Phe Thr Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly Arg 
        115                 120                 125             


Asp Leu Lys Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp Val 
    130                 135                 140                 


Asn Lys Ile Val Phe Lys Ile Leu Ile Gly Arg Lys Asp Lys Asn Lys 
145                 150                 155                 160 


Val Glu Leu Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr Lys 
                165                 170                 175     


Val Ser Gln Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile Leu 
            180                 185                 190         


Asn Leu Thr Ile Asp Ile Pro Tyr Lys Lys Val Asp Glu Ile Val Lys 
        195                 200                 205             


Asp Arg Val Cys Gly Val Asp Met Gly Ile Ala Ile Pro Ile Tyr Val 
    210                 215                 220                 


Ala Leu Asn Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile Asp 
225                 230                 235                 240 


Glu Phe Met Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg Leu 
                245                 250                 255     


Gln Gln Gln Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp Lys 
            260                 265                 270         


Leu Lys Gly Leu Glu Ser Leu Arg Glu Lys Glu Lys Ser Trp Val Lys 
        275                 280                 285             


Thr Tyr Asn His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys Lys 
    290                 295                 300                 


Asn Lys Cys Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly Phe 
305                 310                 315                 320 


Gly Asp Arg Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu Met 
                325                 330                 335     


Ile Lys Tyr Lys Ala Asp Arg Val Gly Ile Lys Val Lys His Val Asn 
            340                 345                 350         


Pro Ala Tyr Thr Ser Gln Thr Cys Ser Glu Cys Gly His Ala Asp Lys 
        355                 360                 365             


Glu Asn Arg Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly Phe 
    370                 375                 380                 


Glu Ala Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser Asp 
385                 390                 395                 400 


Lys Phe Val Lys 
                


<210>  294
<211>  404
<212>  PRT
<213>  Clostridioides difficile

<400>  294

Met Val Ala Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val Glu 
1               5                   10                  15      


Glu Glu Glu Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln 
            20                  25                  30          


Tyr Ala Gln Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr Ser 
        35                  40                  45              


Ala Tyr Leu Ala Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys Asp 
    50                  55                  60                  


Ser Gln Lys Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile Asn 
65                  70                  75                  80  


Phe Gly Lys Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val Lys 
                85                  90                  95      


Lys Asp Phe Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu Arg 
            100                 105                 110         


Gly Phe Thr Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly Arg 
        115                 120                 125             


Asp Leu Lys Phe Tyr Glu Glu Asp Asn Glu Phe Tyr Ile Lys Trp Val 
    130                 135                 140                 


Asn Lys Ile Val Phe Lys Val Leu Ile Gly Arg Lys Asp Lys Asn Lys 
145                 150                 155                 160 


Val Glu Leu Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr Lys 
                165                 170                 175     


Val Ser Gln Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile Leu 
            180                 185                 190         


Asn Leu Thr Ile Asp Ile Pro Tyr Lys Gln Val Asp Glu Ile Val Lys 
        195                 200                 205             


Asp Arg Thr Cys Gly Val Asp Met Gly Ile Ala Ile Pro Ile Tyr Val 
    210                 215                 220                 


Ala Leu Asn Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile Asp 
225                 230                 235                 240 


Glu Phe Met Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg Leu 
                245                 250                 255     


Gln Gln Gln Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp Lys 
            260                 265                 270         


Leu Lys Gly Leu Glu Leu Leu Arg Glu Lys Glu Lys Ser Trp Val Lys 
        275                 280                 285             


Thr Tyr Asn His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys Lys 
    290                 295                 300                 


Asn Lys Cys Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly Phe 
305                 310                 315                 320 


Gly Asp Arg Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu Met 
                325                 330                 335     


Ile Lys Tyr Lys Gly Glu Arg Val Gly Ile Lys Val Lys Tyr Val Asn 
            340                 345                 350         


Pro Ala Tyr Thr Ser Gln Thr Cys Ser Glu Cys Gly His Val Asp Lys 
        355                 360                 365             


Glu Asn Arg Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly Phe 
    370                 375                 380                 


Glu Ala Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser Asp 
385                 390                 395                 400 


Lys Phe Val Lys 
                


<210>  295
<211>  404
<212>  PRT
<213>  Clostridioides difficile

<400>  295

Met Val Ala Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val Glu 
1               5                   10                  15      


Glu Glu Glu Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln 
            20                  25                  30          


Tyr Ala Gln Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr Ser 
        35                  40                  45              


Ala Tyr Leu Ala Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys Tyr 
    50                  55                  60                  


Ser Gln Lys Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile Asn 
65                  70                  75                  80  


Phe Gly Lys Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val Lys 
                85                  90                  95      


Lys Asp Phe Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu Arg 
            100                 105                 110         


Gly Phe Thr Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly Arg 
        115                 120                 125             


Asp Leu Lys Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp Val 
    130                 135                 140                 


Asn Lys Ile Val Phe Lys Ile Leu Ile Gly Arg Lys Asp Lys Asn Lys 
145                 150                 155                 160 


Val Glu Leu Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr Lys 
                165                 170                 175     


Val Ser Gln Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile Leu 
            180                 185                 190         


Asn Leu Thr Ile Asp Ile Pro Cys Lys Lys Val Asp Glu Ile Val Lys 
        195                 200                 205             


Asp Arg Val Cys Gly Val Asp Met Gly Ile Ala Ile Pro Val Tyr Val 
    210                 215                 220                 


Ala Leu Asn Asp Ile Ser Tyr Val Arg Glu Gly Met Gly Thr Ile Asp 
225                 230                 235                 240 


Glu Phe Met Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg Leu 
                245                 250                 255     


Gln Gln Gln Leu Lys Asn Val Thr Gly Gly Lys Gly Arg Lys Asp Lys 
            260                 265                 270         


Leu Lys Gly Leu Glu Leu Leu Arg Glu Lys Glu Lys Ser Trp Val Lys 
        275                 280                 285             


Thr Tyr Asn His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys Lys 
    290                 295                 300                 


Asn Lys Cys Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly Phe 
305                 310                 315                 320 


Gly Asp Arg Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu Met 
                325                 330                 335     


Ile Lys Tyr Lys Gly Glu Arg Val Gly Ile Lys Val Lys Tyr Val Asn 
            340                 345                 350         


Pro Ala Tyr Thr Ser Gln Thr Cys Ser Glu Cys Gly His Val Asp Lys 
        355                 360                 365             


Glu Asn Arg Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Arg Phe 
    370                 375                 380                 


Glu Ala Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Gly Lys Ser Asp 
385                 390                 395                 400 


Lys Phe Val Lys 
                


<210>  296
<211>  404
<212>  PRT
<213>  Clostridioides difficile

<400>  296

Met Val Ala Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val Gly 
1               5                   10                  15      


Glu Glu Glu Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser Gln 
            20                  25                  30          


Tyr Ala Gln Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr Ser 
        35                  40                  45              


Ala Tyr Leu Ala Ser Gly Arg Asp Ile Asn Ser Asp Leu Phe Lys Asp 
    50                  55                  60                  


Ser Lys Lys Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile Asn 
65                  70                  75                  80  


Phe Gly Lys Gly Ile Asp Thr Lys Ser Ser Ile Thr Pro Lys Val Arg 
                85                  90                  95      


Asn Asp Phe Phe Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu Arg 
            100                 105                 110         


Ser Phe Thr Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly Arg 
        115                 120                 125             


Asp Leu Lys Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp Val 
    130                 135                 140                 


Asn Lys Val Val Phe Lys Val Pro Ile Gly Arg Lys Asp Lys Asn Lys 
145                 150                 155                 160 


Val Glu Leu Val His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr Lys 
                165                 170                 175     


Val Ser Gln Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile Leu 
            180                 185                 190         


Asn Leu Thr Ile Asp Ile Pro Tyr Lys Lys Ile Asp Glu Ile Val Lys 
        195                 200                 205             


Gly Arg Val Cys Gly Val Asp Met Gly Ile Ala Ile Pro Val Tyr Val 
    210                 215                 220                 


Ala Leu Asn Asn Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile Asp 
225                 230                 235                 240 


Glu Phe Met Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg Leu 
                245                 250                 255     


Gln Gln Gln Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp Lys 
            260                 265                 270         


Leu Lys Gly Leu Glu Ser Leu Arg Glu Lys Glu Lys Ser Trp Val Lys 
        275                 280                 285             


Thr Tyr Asn His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys Lys 
    290                 295                 300                 


Asn Lys Cys Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly Phe 
305                 310                 315                 320 


Gly Asp Arg Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu Met 
                325                 330                 335     


Ile Lys Tyr Lys Gly Glu Arg Val Gly Ile Lys Val Lys Tyr Val Asn 
            340                 345                 350         


Pro Ala Tyr Thr Ser Gln Thr Cys Ser Glu Cys Gly His Val Asp Lys 
        355                 360                 365             


Glu Asn Arg Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly Phe 
    370                 375                 380                 


Glu Ala Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser Asp 
385                 390                 395                 400 


Lys Phe Val Lys 
                


<210>  297
<211>  407
<212>  PRT
<213>  Clostridium hiranonis

<400>  297

Met Gly Ser Lys Phe Met Ile Thr Val Arg Lys Leu Lys Leu Thr Ile 
1               5                   10                  15      


Ile Asn Asp Asp Glu Thr Lys Arg Asn Glu Gln Tyr Lys Phe Ile Arg 
            20                  25                  30          


Asp Ser Gln Tyr Ala Gln Tyr Gln Gly Leu Asn Leu Ala Met Ser Val 
        35                  40                  45              


Leu Thr Asn Ala Tyr Leu Ser Ser Asn Arg Asp Ile Lys Ser Asp Leu 
    50                  55                  60                  


Phe Lys Glu Thr Gln Lys Asn Leu Lys Asn Ser Ser His Ile Phe Asp 
65                  70                  75                  80  


Asp Ile Thr Phe Gly Lys Gly Thr Asp Asn Lys Ser Leu Ile Asn Gln 
                85                  90                  95      


Lys Val Lys Lys Asp Phe Asn Ser Ala Ile Lys Asn Gly Leu Ala Arg 
            100                 105                 110         


Gly Glu Arg Asn Ile Thr Asn Tyr Lys Arg Thr Phe Pro Leu Met Thr 
        115                 120                 125             


Arg Gly Thr Ala Leu Lys Phe Ser Tyr Lys Asp Asp Cys Ser Asp Glu 
    130                 135                 140                 


Ile Ile Ile Lys Trp Val Asn Lys Ile Val Phe Lys Val Val Ile Gly 
145                 150                 155                 160 


Arg Lys Asp Lys Asn Tyr Leu Glu Leu Met His Thr Leu Asn Lys Val 
                165                 170                 175     


Ile Asn Gly Glu Tyr Lys Val Gly Gln Ser Ser Ile Tyr Phe Asp Lys 
            180                 185                 190         


Ser Asn Lys Leu Ile Leu Asn Leu Thr Leu Tyr Ile Pro Glu Lys Lys 
        195                 200                 205             


Asp Asp Asp Ala Ile Asn Gly Arg Thr Leu Gly Val Asp Leu Gly Ile 
    210                 215                 220                 


Lys Tyr Pro Ala Tyr Val Cys Leu Asn Asp Asp Thr Phe Ile Arg Gln 
225                 230                 235                 240 


His Ile Gly Glu Ser Leu Glu Leu Ser Lys Gln Arg Glu Gln Phe Arg 
                245                 250                 255     


Asn Arg Arg Lys Arg Leu Gln Gln Gln Leu Lys Asn Val Lys Gly Gly 
            260                 265                 270         


Lys Gly Arg Glu Lys Lys Leu Ala Ala Leu Asp Lys Val Ala Val Cys 
        275                 280                 285             


Glu Arg Asn Phe Val Lys Thr Tyr Asn His Thr Ile Ser Lys Arg Ile 
    290                 295                 300                 


Ile Asp Phe Ala Lys Lys Asn Lys Cys Glu Phe Ile Asn Leu Glu Gln 
305                 310                 315                 320 


Leu Thr Lys Asp Gly Phe Asp Asn Ile Ile Leu Ser Asn Trp Ser Tyr 
                325                 330                 335     


Tyr Glu Leu Gln Asn Met Ile Lys Tyr Lys Ala Asp Arg Glu Gly Ile 
            340                 345                 350         


Lys Val Arg Tyr Val Asn Pro Ala Tyr Thr Ser Gln Lys Cys Ser Lys 
        355                 360                 365             


Cys Gly Tyr Ile Asp Lys Glu Asn Arg Pro Thr Gln Glu Lys Phe Lys 
    370                 375                 380                 


Cys Ile Lys Cys Gly Phe Glu Leu Asn Ala Asp His Asn Ala Ala Ile 
385                 390                 395                 400 


Asn Ile Ser Arg Leu Glu Glu 
                405         


<210>  298
<211>  421
<212>  PRT
<213>  Clostridioides difficile

<400>  298

Met Leu Tyr Leu Pro Lys Tyr Ala Ile Ile Leu Leu Thr Cys Arg Ile 
1               5                   10                  15      


Arg Met Val Ala Met Ile Ala Val Lys Lys Leu Lys Leu Thr Ile Val 
            20                  25                  30          


Glu Glu Glu Glu Lys Arg Lys Glu Gln Tyr Lys Phe Ile Arg Asp Ser 
        35                  40                  45              


Gln Tyr Ala Gln Tyr Gln Gly Leu Asn Leu Ala Met Gly Ile Leu Thr 
    50                  55                  60                  


Ser Ala Tyr Leu Ala Ser Gly Arg Asp Ile Lys Ser Asp Leu Phe Lys 
65                  70                  75                  80  


Asp Ser Gln Lys Ser Leu Thr Asn Ser Asn Glu Ile Phe Asn Gly Ile 
                85                  90                  95      


Asn Phe Gly Lys Gly Ile Asp Thr Lys Ser Ser Ile Thr Gln Lys Val 
            100                 105                 110         


Lys Lys Asp Phe Ser Thr Ser Leu Lys Asn Gly Leu Ala Lys Gly Glu 
        115                 120                 125             


Arg Gly Phe Thr Asn Tyr Lys Arg Asp Phe Pro Leu Met Thr Arg Gly 
    130                 135                 140                 


Arg Asp Leu Lys Phe Tyr Glu Glu Asp Lys Glu Phe Tyr Ile Lys Trp 
145                 150                 155                 160 


Val Asn Lys Ile Val Phe Lys Ile Leu Ile Gly Arg Lys Asp Lys Asn 
                165                 170                 175     


Lys Val Glu Leu Ile His Thr Leu Asn Lys Val Leu Asn Lys Glu Tyr 
            180                 185                 190         


Lys Val Ser Gln Ser Ser Leu Gln Phe Asp Lys Asn Asn Lys Leu Ile 
        195                 200                 205             


Leu Asn Leu Thr Ile Asp Ile Pro Tyr Lys Gln Val Asp Glu Ile Val 
    210                 215                 220                 


Lys Gly Arg Val Cys Gly Val Asp Met Gly Ile Ala Ile Pro Val Tyr 
225                 230                 235                 240 


Val Ala Leu Asn Asp Val Ser Tyr Val Arg Glu Gly Met Gly Thr Ile 
                245                 250                 255     


Asp Glu Phe Met Lys Gln Arg Leu Gln Phe Gln Ser Arg Arg Arg Arg 
            260                 265                 270         


Leu Gln Gln Gln Leu Lys Asn Val Asn Gly Gly Lys Gly Arg Lys Asp 
        275                 280                 285             


Lys Leu Lys Gly Leu Glu Ser Leu Arg Glu Lys Glu Lys Ser Trp Val 
    290                 295                 300                 


Lys Thr Tyr Asn His Ala Leu Ser Lys Arg Val Val Glu Phe Ala Lys 
305                 310                 315                 320 


Lys Asn Lys Cys Glu Tyr Ile His Leu Glu Lys Leu Thr Lys Asp Gly 
                325                 330                 335     


Phe Gly Asp Arg Leu Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Glu 
            340                 345                 350         


Met Ile Lys Tyr Lys Ala Asp Arg Val Gly Ile Lys Val Lys His Val 
        355                 360                 365             


Asn Pro Ala Tyr Thr Ser Gln Thr Cys Ser Glu Cys Gly His Val Asp 
    370                 375                 380                 


Lys Glu Asn Arg Glu Thr Gln Ala Lys Phe Lys Cys Leu Glu Cys Gly 
385                 390                 395                 400 


Phe Glu Ala Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser 
                405                 410                 415     


Asp Lys Phe Val Lys 
            420     


<210>  299
<211>  422
<212>  PRT
<213>  Aneurinibacillus danicus

<400>  299

Met Lys His Thr Lys Val Met Arg Tyr Gln Ile Ile Lys Pro Ile Asn 
1               5                   10                  15      


Asp Thr Trp Glu Thr Leu Gly His Val Leu Arg Glu Ile Gln Arg Glu 
            20                  25                  30          


Thr Arg Ala Ala Leu Asn Lys Thr Ile Gln Leu Ala Trp Glu Trp Gln 
        35                  40                  45              


Gly Phe Ser Ala Glu Tyr Lys Gln Arg Tyr Glu Glu Tyr Pro Lys Thr 
    50                  55                  60                  


Lys Asp His Leu Gly Tyr Ser Ala Leu His Gly Tyr Ala Tyr Asn Arg 
65                  70                  75                  80  


Leu Lys Asp Glu Phe Tyr Arg Met Asn Thr Ala Asn Leu Ser Gln Thr 
                85                  90                  95      


Val Lys Arg Ala Ala Asp Lys Trp Lys Ser Asp Leu Lys Asp Val Leu 
            100                 105                 110         


Arg Gly Asp Lys Ser Ile Ala Ser Phe Lys Lys Asp Cys Pro Ile Asp 
        115                 120                 125             


Ile Val Ser Gln Ala Leu Arg Ile Arg Lys Asp Gly Ser Asp Tyr Ile 
    130                 135                 140                 


Met Thr Leu Ser Leu Val Ser Ile Lys Tyr Arg Lys Glu Leu Glu Arg 
145                 150                 155                 160 


Lys Gln Ser Phe Phe Asp Val Leu Ile Ser Ala Asn Asp Lys Thr Gln 
                165                 170                 175     


Arg Asp Ile Leu Asp Arg Leu Ile Ala Gly Glu Tyr Lys Leu Gly Ala 
            180                 185                 190         


Ser Gln Leu Leu Tyr His Lys Lys Lys Trp Phe Val Asn Val Asn Tyr 
        195                 200                 205             


Gln Phe Glu Lys Glu Glu Thr Ala Phe Asp Gln Asp Asn Ile Met Gly 
    210                 215                 220                 


Val Asp Leu Gly Ile Val Tyr Pro Val Tyr Met Ala Phe Asn Asn Ser 
225                 230                 235                 240 


Leu Asn Arg Tyr Lys Ile Glu Gly Gly Glu Ile Glu Arg Phe Arg Ala 
                245                 250                 255     


Gln Val Glu Arg Arg Lys Lys Gln Leu Leu Gln Gln Ala Lys Tyr Cys 
            260                 265                 270         


Gly Asp Gly Arg Arg Gly His Gly Thr Lys Thr Arg Ile Gln Pro Ile 
        275                 280                 285             


Glu Val Val Ser Asp Lys Val Ala Asn Phe Arg Asp Thr Val Asn His 
    290                 295                 300                 


Arg Tyr Ser Arg Tyr Val Val Asp Met Ala Ile Lys His Arg Cys Gly 
305                 310                 315                 320 


Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Ala Ala Glu Asp Thr Phe 
                325                 330                 335     


Leu Lys Arg Trp Ser Tyr Tyr Asp Leu Gln Gln Lys Ile Glu Tyr Lys 
            340                 345                 350         


Ala Lys Glu Ala Gly Ile Gln Val Val Tyr Ile Lys Pro Asp Tyr Thr 
        355                 360                 365             


Ser Gln Arg Cys Ser Lys Cys Gly His Ile Glu Arg Asp Asn Arg Thr 
    370                 375                 380                 


Glu Gln Ala Thr Phe Glu Cys Lys Ser Cys Gly Phe Lys Thr Asn Ala 
385                 390                 395                 400 


Asp Phe Asn Ala Ala Arg Asn Ile Ala Thr Lys Asp Ile Glu Lys Ile 
                405                 410                 415     


Ile Ala Glu Thr Leu Lys 
            420         


<210>  300
<211>  424
<212>  PRT
<213>  Parageobacillus thermoglucosidasius

<400>  300

Met Lys Tyr Thr Lys Val Met Arg Tyr Gln Ile Ile Lys Pro Leu Asn 
1               5                   10                  15      


Ala Glu Trp Asp Glu Leu Gly Met Val Leu Arg Asp Ile Gln Lys Glu 
            20                  25                  30          


Thr Arg Ala Ala Leu Asn Lys Thr Ile Gln Leu Cys Trp Glu Tyr Gln 
        35                  40                  45              


Gly Phe Ser Ala Asp Tyr Lys Gln Ile His Gly Gln Tyr Pro Lys Leu 
    50                  55                  60                  


Lys Asp Val Leu Gly Tyr Thr Ser Met His Gly Tyr Ala Tyr Asp Arg 
65                  70                  75                  80  


Leu Lys Asn Glu Phe Ser Lys Ile Ala Ser Ser Asn Leu Ser Gln Thr 
                85                  90                  95      


Ile Lys Arg Ala Val Asp Lys Trp Asn Ser Asp Leu Lys Glu Ile Leu 
            100                 105                 110         


Arg Gly Asp Arg Ser Ile Pro Asn Phe Arg Lys Asp Cys Pro Ile Asp 
        115                 120                 125             


Ile Val Lys Gln Ser Thr Lys Ile Gln Lys Cys Asn Asp Gly Tyr Val 
    130                 135                 140                 


Leu Ser Leu Gly Leu Ile Asn Arg Glu Tyr Lys Asn Glu Leu Gly Arg 
145                 150                 155                 160 


Lys Asn Gly Val Phe Asp Val Leu Ile Lys Ala Asn Asp Lys Thr Gln 
                165                 170                 175     


Gln Thr Ile Leu Glu Arg Ile Ile Asn Gly Asp Tyr Thr Tyr Thr Ala 
            180                 185                 190         


Ser Gln Ile Ile Asn His Lys Asn Lys Trp Phe Ile Asn Leu Thr Tyr 
        195                 200                 205             


Gln Phe Glu Thr Lys Glu Thr Ala Leu Asp Pro Asn Asn Val Met Gly 
    210                 215                 220                 


Val Asp Leu Gly Ile Val Tyr Pro Val Tyr Ile Ala Phe Asn Asn Ser 
225                 230                 235                 240 


Leu His Arg Tyr His Ile Lys Gly Gly Glu Ile Glu Arg Phe Arg Arg 
                245                 250                 255     


Gln Val Glu Lys Arg Lys Arg Glu Leu Leu Asn Gln Gly Lys Tyr Cys 
            260                 265                 270         


Gly Asp Gly Arg Lys Gly His Gly Tyr Ala Thr Arg Thr Lys Ser Ile 
        275                 280                 285             


Glu Ser Ile Ser Asp Lys Ile Ala Arg Phe Arg Asp Thr Cys Asn His 
    290                 295                 300                 


Lys Tyr Ser Arg Phe Ile Val Asp Met Ala Leu Lys His Lys Cys Gly 
305                 310                 315                 320 


Ile Ile Gln Met Glu Asp Leu Thr Gly Ile Ser Lys Glu Ser Thr Phe 
                325                 330                 335     


Leu Lys Asn Trp Thr Tyr Tyr Asp Leu Gln Gln Lys Ile Glu Tyr Lys 
            340                 345                 350         


Ala Arg Glu Ala Gly Ile Gln Val Ile Lys Ile Glu Pro Gln Tyr Thr 
        355                 360                 365             


Ser Gln Arg Cys Ser Lys Cys Gly Tyr Ile Asp Lys Glu Asn Arg Gln 
    370                 375                 380                 


Glu Gln Ala Thr Phe Lys Cys Ile Glu Cys Gly Phe Glu Thr Asn Ala 
385                 390                 395                 400 


Asp Tyr Asn Ala Ala Arg Asn Ile Ala Ile Pro Asn Ile Asp Lys Ile 
                405                 410                 415     


Ile Arg Lys Thr Leu Lys Met Gln 
            420                 


<210>  301
<211>  427
<212>  PRT
<213>  Brevibacillus centrosporus

<400>  301

Met Leu Thr Lys Val Met Arg Tyr Gln Ile Ile Lys Pro Leu Asp Asp 
1               5                   10                  15      


Asp Trp Asp Val Leu Gly Gln Val Leu Arg Thr Val Gln Arg Glu Thr 
            20                  25                  30          


His Ala Leu Leu Asn Lys Thr Ile Gln Leu Ala Trp Glu Trp Gln Gly 
        35                  40                  45              


Phe Ser Ser Glu Tyr Lys Glu Lys Tyr Gly Leu Tyr Pro Ile Gln Gln 
    50                  55                  60                  


Glu Ile Leu Pro Lys Lys Lys Gly Gly Asn Val Gly Ser Ile Met His 
65                  70                  75                  80  


Tyr Ala Tyr Asp Gln Leu Lys Asp Ile Tyr Thr Val Ser Asp Arg Arg 
                85                  90                  95      


Asn Leu Asn Gln Ser Ile Lys Arg Ala Thr Asp Lys Trp Lys Ser Asp 
            100                 105                 110         


Val Pro Asp Ile Arg Lys Gly Glu Lys Ser Ile Pro Ser Phe Lys Lys 
        115                 120                 125             


Asp Cys Pro Ile Asp Val Val Ser Gln Ala Tyr Ser Leu His Arg Gly 
    130                 135                 140                 


Ser Glu Gly Phe Val Met Arg Ala Gly Leu Met Ser Thr Glu Tyr Lys 
145                 150                 155                 160 


Lys Glu Leu Gly Arg Arg Phe Gly Ser Phe Asp Leu Leu Leu Asn Val 
                165                 170                 175     


Lys Asp Asn Thr Gln Arg Thr Ile Ile Glu Arg Leu Ile Ser Gly Glu 
            180                 185                 190         


Tyr Lys Ala Gly Val Ala Gln Ile Leu Arg His Lys Lys Asp Trp Phe 
        195                 200                 205             


Val Asn Leu Thr Tyr Ser Phe Glu His Val Asp Ser Leu Leu Asn Pro 
    210                 215                 220                 


Asp Arg Ile Met Gly Val Asp Leu Gly Ile Val Tyr Pro Val Tyr Leu 
225                 230                 235                 240 


Ala Phe Asn Asp Leu Phe Glu Arg Tyr Lys Ile Asp Gly Gly Glu Ile 
                245                 250                 255     


Glu Ser Phe Arg Lys Gln Val Glu Arg Arg Arg Lys Gln Gln Asn Trp 
            260                 265                 270         


Gln Gly Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Thr His Thr 
        275                 280                 285             


Arg Ile Lys Pro Thr Glu Val Thr Glu Glu Arg Ile Ala Asn Phe Arg 
    290                 295                 300                 


Asp Ser Cys Asn His Lys Tyr Ser Arg Phe Val Val Glu Ile Ala Leu 
305                 310                 315                 320 


Lys His Arg Cys Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Tyr Ser 
                325                 330                 335     


Lys Ala Thr Asp Asp Ala Phe Leu Lys Asn Trp Ala Tyr His Asp Leu 
            340                 345                 350         


Gln Gln Lys Ile Glu Tyr Lys Ala Lys Glu Val Gly Ile Lys Val Val 
        355                 360                 365             


Lys Val Lys Pro Glu Cys Thr Ser Gln Arg Cys Ser Lys Cys Gly His 
    370                 375                 380                 


Ile Ala Lys Glu Asn Arg Gln Asp Arg Glu Phe Leu Cys Lys Gly Cys 
385                 390                 395                 400 


Gly Phe Gln Val His Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Thr 
                405                 410                 415     


Lys Asp Ile Glu Glu Ile Ile Lys Gln Ala Leu 
            420                 425         


<210>  302
<211>  428
<212>  PRT
<213>  Clostridium pasteurianum

<400>  302

Met Asn Lys Cys Ile Lys Ile Thr Ile Lys Asn Cys Asn Gln Leu Asn 
1               5                   10                  15      


Phe Thr Asn Ile Asn Lys Thr Leu Ser Asn Ile Arg Tyr Met Thr Cys 
            20                  25                  30          


Lys Ala Ser Asn Lys Ala Met Gln Met Tyr Tyr Met Trp Glu Tyr Glu 
        35                  40                  45              


Arg Met Asn Tyr Lys Lys Leu Asn Gly Gln Tyr Pro Ile Asp Lys Asp 
    50                  55                  60                  


Leu Phe Gly Lys Thr Tyr Arg Asn Val Val Glu Gly Tyr Met Lys Glu 
65                  70                  75                  80  


Ile Met Asn Ile Val Asn Thr Ser Asn Val Ser Gln Thr Asn Ala Phe 
                85                  90                  95      


Val Leu Lys Lys Trp Asn Ser Asp Lys Gln Asp Ile Leu Asn Tyr Arg 
            100                 105                 110         


Lys Ser Val Ala Ser Phe Lys Leu Asn Met Pro Ile Tyr Ile Tyr Asn 
        115                 120                 125             


Lys Asn Tyr Lys Ile Ile Gln Gly Asn Asn Gly Tyr Glu Ile Asp Ala 
    130                 135                 140                 


Ala Ile Phe Asn Lys Lys Gln Asp Leu Arg His Val Thr Phe Asn Ile 
145                 150                 155                 160 


Asp Lys Leu Asp Asn Asn Lys Lys Val Thr Leu Asn Lys Ile Ile Ser 
                165                 170                 175     


Gly Ile Tyr Lys Gln Gly Ala Ala Gln Ile Ile Gln Asp Lys Lys Gly 
            180                 185                 190         


Lys Trp Tyr Phe Ile Ile Ser Phe Ser Phe Val Pro Asp Ile Lys Glu 
        195                 200                 205             


Leu Asp Lys Asn Arg Ile Leu Gly Val Asp Leu Gly Ile Thr Asn Thr 
    210                 215                 220                 


Ala Thr Leu Gln Ile Trp Asp Asn Asn Glu Lys Lys Trp Asp Lys Leu 
225                 230                 235                 240 


Leu Tyr Arg Glu Cys Ile Leu Asp Gly Lys Glu Ser Ile His Phe Arg 
                245                 250                 255     


Gln Lys Val Glu Ala Arg Arg Arg Ser Met Leu Ile Ser Cys Lys Val 
            260                 265                 270         


Ala Gly Asp Gly Arg Ser Gly His Gly Thr Lys Thr Lys Ile Arg Ser 
        275                 280                 285             


Ala Ser Asn Ile Gly Asp Lys Ile Asn Asn Phe Arg Asp Thr Leu Asn 
    290                 295                 300                 


His Lys Tyr Ser Lys Tyr Ile Val Asp Phe Ala Val Lys His Asn Cys 
305                 310                 315                 320 


Gly Thr Val Gln Leu Glu Asp Leu Thr Gly Phe Asn Pro Glu Asn Asn 
                325                 330                 335     


Phe Leu Lys Ser Trp Pro Tyr Phe Asp Met Gln Ser Lys Ile Lys Tyr 
            340                 345                 350         


Lys Ser Lys Glu Lys Gly Ile Asp Ile Lys Ile Ile Asn Pro Tyr Lys 
        355                 360                 365             


Thr Ser Gln Arg Cys Ser Ile Cys Gly Cys Ile Asp Lys Leu Asn Arg 
    370                 375                 380                 


Asp Ser Lys Asn Asn Gln Ser Ile Phe Lys Cys Ile Asn Cys Gly Tyr 
385                 390                 395                 400 


Glu Glu His Ala Asp Ile Asn Ala Ala Lys Asn Ile Ala Leu Pro Asn 
                405                 410                 415     


Ile Glu Lys Leu Ile Lys Asn Phe Ala Lys Ile Pro 
            420                 425             


<210>  303
<211>  433
<212>  PRT
<213>  Eubacterium siraeum

<400>  303

Met Val Cys Asn Lys Val Val Lys Ile Ala Leu Ile Cys Asp Gln Ile 
1               5                   10                  15      


Asp Lys Asp Gly Lys Asp Val Asn Tyr Asn Asp Ile Tyr Lys Leu Leu 
            20                  25                  30          


Trp Asp Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Val Ile Arg 
        35                  40                  45              


Leu Cys Trp Glu Trp Ser Gly Tyr Ser Ser Glu Tyr Phe Lys Thr His 
    50                  55                  60                  


Glu Glu Tyr Pro Lys Asp Lys Glu Ile Phe Gly Ile Ser Leu Arg Gly 
65                  70                  75                  80  


Tyr Leu Tyr Asp Arg Ile Lys Gly Asp Tyr Asn Leu Tyr Ser Gly Asn 
                85                  90                  95      


Leu Ser Gln Ser Ala Glu Ile Ala Tyr Lys Glu Tyr Lys Asn Ser Leu 
            100                 105                 110         


Lys Asp Val Leu Arg Gly Asp Lys Ser Ile Ile Asn Tyr Arg Glu Asn 
        115                 120                 125             


Gln Pro Leu Asp Ile Lys Asn Lys Ala Ile Gln Leu Leu Tyr Glu Asn 
    130                 135                 140                 


Asp Asn Phe Phe Val Arg Val Ala Leu Ile Asn Lys Asp Lys Gln Lys 
145                 150                 155                 160 


Glu Leu Asn Phe Lys Asp Cys Ser Val Arg Phe Lys Leu Leu Val Lys 
                165                 170                 175     


Asp Asp Ser Thr Arg Thr Ile Leu Glu Arg Cys Phe Asp Glu Val Tyr 
            180                 185                 190         


Thr Ile Thr Ala Ser Lys Ile Met Tyr Asn Lys Lys Lys Lys Gln Trp 
        195                 200                 205             


Tyr Ile Asn Leu Gly Tyr Lys Phe Thr Lys Glu Ile Asp Lys Thr Leu 
    210                 215                 220                 


Asp Lys Asp Arg Ile Leu Gly Val Asp Leu Gly Val Ile Asn Pro Leu 
225                 230                 235                 240 


Val Ala Ser Val Tyr Gly Ser Tyr Asp Arg Leu Ile Ile Gly Gly Gly 
                245                 250                 255     


Glu Ile Asp Lys Phe Arg Lys Arg Val Glu Ala Asn Lys Val Gln Met 
            260                 265                 270         


Leu Lys Gln Gly Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Val 
        275                 280                 285             


Asn Thr Arg Asn Lys Pro Ala Tyr Asn Ile Glu Asp Lys Ile Ser Arg 
    290                 295                 300                 


Phe Arg Asp Thr Val Asn His Lys Tyr Ser Lys Ala Val Val Asp Tyr 
305                 310                 315                 320 


Ala Val Lys Asn Asn Cys Gly Thr Ile Gln Met Glu Asp Leu Lys Gly 
                325                 330                 335     


Ile Thr Gln Asn Lys Asn Glu Arg Tyr Leu Lys Asn Trp Thr Tyr Phe 
            340                 345                 350         


Asp Leu Gln Thr Lys Ile Glu Tyr Lys Ala Lys Ala Leu Gly Ile Glu 
        355                 360                 365             


Val Lys Tyr Lys Asn Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys 
    370                 375                 380                 


Gly His Ile Ala Glu Glu Asn Arg Pro Glu Gln Lys Thr Phe Lys Cys 
385                 390                 395                 400 


Val Lys Cys Gly Phe Lys Val Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
                405                 410                 415     


Leu Ala Ile Lys Asp Ile Asp Lys Ile Ile Glu Gln Tyr Tyr Asn Lys 
            420                 425                 430         


Gly 
    


<210>  304
<211>  438
<212>  PRT
<213>  Bacillus toyonensis

<400>  304

Met Lys Tyr Gln Ile Leu Cys Pro Leu Asn Val Asp Trp Thr Ile Phe 
1               5                   10                  15      


Glu Lys His Leu Arg Asn Leu Thr Tyr Gln Val Arg Thr Ile Ser Asn 
            20                  25                  30          


Arg Thr Ile Gln Gln Leu Trp Glu Phe Asp Ala Leu Ser Phe Asp Tyr 
        35                  40                  45              


Phe Lys Glu Arg Gly Thr Tyr Pro Thr Val Gln Asp Leu Tyr Gly Cys 
    50                  55                  60                  


Thr Gln Lys Lys Ile Asp Gly Tyr Ile Tyr His Thr Leu Gln Ser Lys 
65                  70                  75                  80  


Tyr Pro Asp Ile His Lys Gly Asn Met Ser Thr Thr Leu Gln Lys Ile 
                85                  90                  95      


Ile Lys Thr Trp Lys Ser Arg Arg Asn Glu Ile Arg Lys Gly Glu Met 
            100                 105                 110         


Ser Ile Pro Ser Phe Arg Asn Arg Ile Pro Ile Asp Leu His Asn Asn 
        115                 120                 125             


Ser Val Asp Ile Thr Lys Glu Lys Asn Gly Asp Tyr Ile Ala Gly Ile 
    130                 135                 140                 


Ser Leu Phe Ser Arg Asp Phe His Lys Glu Asn Asp Asp Val Pro Lys 
145                 150                 155                 160 


Gly Lys Ile Phe Val Lys Leu Ala Thr Gln Lys Gln Lys Ser Met Lys 
                165                 170                 175     


Val Ile Leu Asp Arg Leu Ile Asn Gln Thr Tyr Ser Lys Gly Ala Cys 
            180                 185                 190         


Met Ile His Lys Tyr Lys Asn Lys Trp Tyr Leu Ser Ile Thr Tyr Lys 
        195                 200                 205             


Phe Asn Ala Ile Lys Glu Asn Lys Phe Asp Lys Glu Leu Ile Met Gly 
    210                 215                 220                 


Ile Asp Leu Gly Gly Ile Asn Thr Val Tyr Ser Ala Phe Asn Glu Gly 
225                 230                 235                 240 


Phe Ile Arg Ser Asn Ile Lys Ser Asp Glu Ile Ile Arg Gln Arg Arg 
                245                 250                 255     


Ile Asn Leu Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly 
            260                 265                 270         


Lys Gly Arg Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys 
        275                 280                 285             


Ile Ala Lys Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile 
    290                 295                 300                 


Val Lys Gln Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu 
305                 310                 315                 320 


Leu Lys Gly Ile Ser Lys Asn Asp Arg Ile Leu Lys Asp Trp Thr Tyr 
                325                 330                 335     


Phe Asp Leu Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile 
            340                 345                 350         


Glu Val Ile Lys Val Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln 
        355                 360                 365             


Cys Gly Tyr Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Thr Phe Glu 
    370                 375                 380                 


Cys Lys Gln Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys 
385                 390                 395                 400 


Asn Ile Ser Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala 
                405                 410                 415     


Val Gln Ser Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu 
            420                 425                 430         


Glu Leu Gly Tyr Leu Asp 
        435             


<210>  305
<211>  439
<212>  PRT
<213>  Ruminococcus sp.

<400>  305

Met Ser Lys Asp Lys Tyr Val Ile Thr Arg Lys Ile Lys Leu Leu Pro 
1               5                   10                  15      


Val Gly Asp Lys Asp Glu Val Asp Arg Val Tyr Asp Phe Ile Arg Asp 
            20                  25                  30          


Gly Gln Tyr Ser Gln Tyr Asn Ala Leu Asn Ile Leu Met Gly Gln Leu 
        35                  40                  45              


Ala Ser Lys Tyr Tyr Glu Cys Lys Arg Asp Leu Ser Ser Ala Glu Phe 
    50                  55                  60                  


Lys Glu Ala Gln Lys Ser Ile Leu Ser Asn Ser Asn Pro Asn Leu Cys 
65                  70                  75                  80  


Asp Ile Glu Phe Ala Lys Gly Cys Asp Thr Lys Ser Ala Val Val Gln 
                85                  90                  95      


Lys Val Lys Gln Asp Phe Ser Ile Ala Ile Lys Asn Gly Leu Pro Arg 
            100                 105                 110         


Gly Glu Arg Asn Ile Thr Asn Tyr Lys Arg Thr Val Pro Leu Ile Thr 
        115                 120                 125             


Arg Gly Arg Asp Leu Val Phe Ile His Gly Tyr Glu Asn Tyr Thr Glu 
    130                 135                 140                 


Phe Leu Asp Asn Leu Tyr Thr Asp Arg Asn Leu Lys Val Phe Ile Lys 
145                 150                 155                 160 


Trp Ile Asn Lys Ile Gln Phe Lys Ile Val Phe Gly Asn Pro Tyr Lys 
                165                 170                 175     


Ser Ala Glu Leu Arg Asn Val Val Gln Asn Ile Phe Glu Glu Arg Tyr 
            180                 185                 190         


Lys Val Asn Gly Ser Ser Ile Lys Ile Asp Asp Gly Asp Ile Ile Leu 
        195                 200                 205             


Asn Leu Ser Leu Thr Met Pro Lys Glu Ile Lys Glu Leu Asp Glu Asn 
    210                 215                 220                 


Lys Val Val Gly Val Asp Leu Gly Leu Ala Ile Pro Ala Val Cys Ala 
225                 230                 235                 240 


Leu Asn Thr Asn Gly Tyr Ser Arg Lys Ser Ile Gly Asn Ala Asn Asp 
                245                 250                 255     


Phe Ser Arg Val Arg Thr Lys Ile Lys Ala Gln Arg Arg Arg Leu Gln 
            260                 265                 270         


Lys Ser Leu Ser Gln Thr Ser Gly Gly His Gly Arg Gly Lys Lys Leu 
        275                 280                 285             


Arg Ala Leu Asn Arg Phe Ser Glu Tyr Glu Lys His Trp Val Gln Asn 
    290                 295                 300                 


Tyr Ser His Tyr Val Ser Lys Gln Val Val Asp Phe Ala Ile Lys Asn 
305                 310                 315                 320 


Asn Ala Lys Tyr Ile Asn Leu Glu Asp Leu Glu Gly Tyr Gly Asp Asp 
                325                 330                 335     


Glu Lys Asn Lys Phe Ile Leu Ser Asn Trp Ser Tyr Tyr Gln Val Gln 
            340                 345                 350         


Gln Tyr Ile Thr Tyr Lys Ala Glu Lys Tyr Gly Ile Glu Val Arg Lys 
        355                 360                 365             


Ile Asn Pro Tyr Arg Thr Ser Gln Val Cys Ser Cys Cys Gly His Trp 
    370                 375                 380                 


Glu Asn Gly Gln Arg Ile Asp Gln Ala Thr Phe Ile Cys Lys Asn Pro 
385                 390                 395                 400 


Glu Cys Lys Asn Phe Gly Glu Lys Val Asn Ala Asp Phe Asn Ala Ala 
                405                 410                 415     


Arg Asn Ile Ala Leu Ser Thr Asp Trp Ser Asp Ile Asp Glu Lys Lys 
            420                 425                 430         


Asn Lys Lys Asn Lys Lys Lys 
        435                 


<210>  306
<211>  440
<212>  PRT
<213>  Ruminococcus sp.

<400>  306

Met Val Lys Val Val Lys Ile Tyr Leu Ile Ser Glu Gln Phe Asp Lys 
1               5                   10                  15      


Ala Gly Asn Arg Ile Asp Tyr Lys Glu Val Asn Lys Ile Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Thr Val Gln Leu Leu 
        35                  40                  45              


Trp Glu Trp Asn Asn Phe Ser Ser Asp Tyr Val Lys Ala Ser Gly Ile 
    50                  55                  60                  


Tyr Pro Lys Ala Lys Asp Ile Phe Gly Tyr Ser Ser Val His Gly Gln 
65                  70                  75                  80  


Ala Asn Lys Glu Leu Arg Thr Lys Leu Ile Leu Asn Ser Ser Asn Leu 
                85                  90                  95      


Ser Thr Thr Thr Met Asp Val Cys Lys Ile Phe Asn Thr Tyr Lys Lys 
            100                 105                 110         


Glu Val Trp Glu Gly Lys Arg Ser Val Pro Ser Tyr Lys Ser Asp Gln 
        115                 120                 125             


Pro Leu Asp Leu His Lys Asp Ser Ile Lys Leu Ile Tyr Glu Asn Asn 
    130                 135                 140                 


Gln Phe Tyr Val Arg Leu Ala Leu Leu Lys Lys Ala Glu Phe Ala Lys 
145                 150                 155                 160 


Tyr Gly Phe Lys Asp Gly Phe Arg Phe Lys Met Gln Val Lys Asp Asn 
                165                 170                 175     


Ser Thr Lys Thr Ile Leu Glu Arg Cys Phe Asp Glu Val Tyr Lys Ile 
            180                 185                 190         


Asn Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Met Trp Lys Leu 
        195                 200                 205             


Asn Leu Ser Tyr Ser Phe Asp Asn Lys Asn Ile Ser Glu Leu Asp Lys 
    210                 215                 220                 


Glu Lys Ile Leu Gly Val Asp Val Gly Val Asn Cys Pro Leu Val Ala 
225                 230                 235                 240 


Ser Val Phe Gly Asp Arg Asp Arg Phe Ile Ile Lys Gly Gly Glu Ile 
                245                 250                 255     


Glu Lys Phe Arg Lys Ser Val Glu Ala Arg Arg Arg Ser Met Leu Glu 
            260                 265                 270         


Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Arg Lys Lys 
        275                 280                 285             


Arg Thr Glu Pro Ala Leu Asn Ile Gly Asp Lys Ile Ala Arg Phe Arg 
    290                 295                 300                 


Asp Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr Ala Val 
305                 310                 315                 320 


Lys Lys Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr Gly Ile Thr 
                325                 330                 335     


Ser Lys Ser Asp Arg Phe Leu Lys Asp Trp Thr Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Thr Lys Ile Glu Asn Lys Ala Lys Glu Val Gly Ile Asn Val Val Tyr 
        355                 360                 365             


Ile Ala Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly Tyr Ile 
    370                 375                 380                 


His Lys Asp Asn Arg Pro Asn Gln Ala Lys Phe Arg Cys Leu Lys Cys 
385                 390                 395                 400 


Asp Phe Glu Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Gly Ile 
                405                 410                 415     


Lys Asn Ile Ala Lys Ile Ile Glu Lys Asp Leu Lys Lys Gln Lys Ser 
            420                 425                 430         


Glu Val Gln Val Asn Glu Asn Lys 
        435                 440 


<210>  307
<211>  441
<212>  PRT
<213>  Clostridium perfringens

<400>  307

Met Ser Thr Lys Cys Val Lys Ile Ala Leu Glu Tyr Ser Lys Asp Asn 
1               5                   10                  15      


Val Leu Lys Lys Glu Glu Phe Leu Lys Glu Leu Lys Asp Ile Gln Tyr 
            20                  25                  30          


Lys Thr Trp Leu Ala Ser Asn Arg Ala Ile Thr Tyr Phe Tyr Ser Asn 
        35                  40                  45              


Asp Met Gln Asn Leu Ile Gln Lys Asp Ile Gly Ile Pro Lys Glu Asp 
    50                  55                  60                  


Asp Lys Lys Leu Phe Gly Lys Gly Phe Gly Ser Trp Val Glu Asn Arg 
65                  70                  75                  80  


Met Asn Glu Ile Met Tyr Gly Ala Leu Ser Asn Asn Val Ala Gln Thr 
                85                  90                  95      


Arg Gln Phe Val Asn Asn Arg Tyr Ser Gln Asp Lys Lys Asn Gly Leu 
            100                 105                 110         


Leu Lys Gly Asn Ile Ser Leu Ser Gln Phe Lys Arg Asp Met Pro Ile 
        115                 120                 125             


Ile Ile His Asn Lys Ala Tyr Asn Ile Ile Asn Thr Pro Lys Gly Leu 
    130                 135                 140                 


Gly Ile Glu Ile Gly Phe Phe Asn Lys Glu Lys Gln Gln Lys Leu Gly 
145                 150                 155                 160 


Val Lys Arg Ile Lys Phe Leu Phe Pro Lys Leu Asp Asn Ser Ser Lys 
                165                 170                 175     


Gln Ile Leu Ile Arg Leu Met Asp Lys Thr Tyr Lys Gln Gly Ser Ile 
            180                 185                 190         


Gln Ile Val Asn Asn Lys Arg Lys Lys Lys Trp Leu Val Ala Ile Ser 
        195                 200                 205             


Tyr Thr Phe Glu Asn Lys Leu Gln Lys Pro Leu Ser Asp Asn Leu Val 
    210                 215                 220                 


Met Gly Ile Asp Leu Gly Ile Thr Asn Val Ala Thr Met Ser Ile Phe 
225                 230                 235                 240 


Asn Thr Lys Lys Glu Glu Tyr Lys Ala Met Tyr Trp Lys Glu Arg Ile 
                245                 250                 255     


Ile Asp Gly Thr Glu Leu Ile His Tyr Arg Gln Lys Ile Glu Ala Arg 
            260                 265                 270         


Arg Lys Ser Leu Ser Ile Ala Ser Lys Trp Ser Ser Asp Ser Ala Ile 
        275                 280                 285             


Gly His Gly Tyr Lys Arg Arg Met Lys Lys Ala Asn Ser Val Gly Asp 
    290                 295                 300                 


Lys Tyr Asn Arg Phe Lys Asp Thr Tyr Asn His Lys Val Ser Arg Tyr 
305                 310                 315                 320 


Ile Val Asp Leu Ala Tyr Lys Tyr Gly Val Lys Thr Ile Gln Met Glu 
                325                 330                 335     


Asp Leu Ser Gly Phe Ser Glu Tyr Gln Ser Glu Ser Leu Leu Lys Asn 
            340                 345                 350         


Trp Ser Tyr Tyr Asp Leu Gln Asn Lys Ile Lys Tyr Lys Ala Glu Glu 
        355                 360                 365             


Lys Gly Ile Asn Thr Ile Phe Ile Asn Pro Gln Tyr Thr Ser Lys Arg 
    370                 375                 380                 


Cys Ser Lys Cys Gly Asn Ile His Glu Asp Asn Arg Asp Cys Lys Asn 
385                 390                 395                 400 


Asn Gln Ala Glu Phe Lys Cys Val Ile Cys Lys Tyr Ser Glu Asn Ala 
                405                 410                 415     


Asp Ile Asn Ala Ser Lys Asn Ile Ala Ile Pro Tyr Ile Asp Lys Ile 
            420                 425                 430         


Ile Ser Glu Tyr Ile Lys Asp Ile Lys 
        435                 440     


<210>  308
<211>  443
<212>  PRT
<213>  Bacillus thuringiensis

<400>  308

Met Lys Tyr Gln Ile Val Cys Pro Val Asn Ile Glu Trp Lys Thr Phe 
1               5                   10                  15      


Glu Ile Tyr Leu Arg Thr Leu Ser Tyr His Phe Arg Thr Ile Gly Asn 
            20                  25                  30          


Arg Thr Ile Gln Lys Leu Trp Glu Tyr Asp Asn Gln Ser Leu Lys His 
        35                  40                  45              


Phe Lys Asp Thr Gly Gln Tyr Pro Ser Ala Gln Gln Leu Tyr Gly Cys 
    50                  55                  60                  


Thr Gln Lys Thr Ile Ser Gly Tyr Ile Tyr Asp Gln Leu Lys Glu Glu 
65                  70                  75                  80  


Tyr Gln Asp Ile Asn Lys Ala Asn Met Ser Thr Thr Leu Gln Lys Thr 
                85                  90                  95      


Ile Arg Thr Trp Asn Ser Arg Lys Lys Glu Ile Trp Ser Gly Glu Met 
            100                 105                 110         


Ser Ile Pro Ser Phe Arg Asn Asn Leu Pro Ile Asp Ile His Gly Asn 
        115                 120                 125             


Ser Ile Gln Ile Ile Lys Glu Lys Ser Gly Asp Tyr Ile Ala Ser Val 
    130                 135                 140                 


Ser Leu Phe Ser Ser Lys Phe Ile Lys Glu Asn Asp Leu Pro Asn Gly 
145                 150                 155                 160 


Lys Ile Leu Val Lys Leu Ser Thr Arg Lys Gln Asn Ser Met Lys Val 
                165                 170                 175     


Ile Leu Asp Arg Ile Ile Asp Ser Thr Tyr Ala Lys Gly Ala Cys Met 
            180                 185                 190         


Leu His Lys His Lys Lys Lys Trp Tyr Leu Ser Ile Thr Tyr Lys Ser 
        195                 200                 205             


Asn Ile Lys Glu Glu Leu Lys Phe Asp Glu Asp Leu Ile Met Gly Ile 
    210                 215                 220                 


Asp Met Gly Lys Ile Asn Val Leu Tyr Phe Ala Phe Asn Lys Gly Leu 
225                 230                 235                 240 


Val Arg Gly Ala Ile Ser Gly Glu Glu Ile Glu Ala Phe Arg Lys Lys 
                245                 250                 255     


Ile Glu His Arg Arg Ile Ser Leu Leu Arg Gln Gly Lys Tyr Cys Ser 
            260                 265                 270         


Gly Asn Arg Ile Gly Lys Gly Arg Glu Lys Arg Ile Lys Pro Ile Asp 
        275                 280                 285             


Val Leu Asn Asp Lys Val Ala Lys Phe Arg Asn Ala Thr Asn His Lys 
    290                 295                 300                 


Tyr Ala Asn Tyr Ile Val Gln Gln Cys Leu Lys Tyr Asn Cys Gly Thr 
305                 310                 315                 320 


Ile Gln Leu Glu Asp Leu Lys Gly Ile Ser Lys Glu Gln Thr Phe Leu 
                325                 330                 335     


Lys Asn Trp Thr Tyr Phe Asp Leu Gln Glu Lys Ile Lys Asn Gln Ala 
            340                 345                 350         


Asn Gln Tyr Gly Met Lys Val Val Lys Ile Asp Pro Ser Tyr Thr Ser 
        355                 360                 365             


Gln Arg Cys Ser Glu Cys Gly Tyr Ile His Lys Asn Asn Arg Gln Asp 
    370                 375                 380                 


Gln Ser Thr Phe Glu Cys Gln Gln Cys Ser Phe Lys Val His Ala Asp 
385                 390                 395                 400 


Tyr Asn Ala Ala Lys Asn Ile Ser Val Tyr Asn Ile Glu Lys Val Ile 
                405                 410                 415     


Gln Lys Gln Leu Glu Leu Gln Glu Lys Leu Asn Gln Thr Lys Tyr Lys 
            420                 425                 430         


Glu Gln Tyr Ile Glu Gln Met Lys Asn Ile Asn 
        435                 440             


<210>  309
<211>  444
<212>  PRT
<213>  Clostridium perfringens

<400>  309

Met Thr Thr Lys Ser Ile Lys Leu Ala Ile Glu Phe Ser Lys Glu Asn 
1               5                   10                  15      


Cys Val Asp Lys Lys Lys Phe Phe Asp Asn Ile Lys Asp Ile Gln Tyr 
            20                  25                  30          


Lys Thr Trp Lys Ala Ser Asn Arg Ala Ile Thr Tyr Leu Tyr Ser Asn 
        35                  40                  45              


Asp Met Gln Asn Leu Ile Gln Lys Asp Val Gly Leu Pro Lys Gln Glu 
    50                  55                  60                  


Asp Lys Asp Ile Phe Gly Lys Ser Phe Gly Ala Trp Ile Glu Asn Lys 
65                  70                  75                  80  


Met Asn Glu Ile Ile Asp Gly Ala Asn Ser Gly Asn Val Ala Gln Gln 
                85                  90                  95      


Arg Ala Phe Val Ile Asn Arg Tyr Asn Gln Asp Lys Lys Asn Gly Leu 
            100                 105                 110         


Leu Glu Gly Lys Val Thr Leu Thr Gln Phe Lys Arg Asn Ile Pro Ile 
        115                 120                 125             


Ile Ile His Asn Lys Ser Tyr Lys Ile Ile Glu Thr Asn Lys Gly Leu 
    130                 135                 140                 


Gly Val Glu Val Gly Leu Phe Asn Lys Lys Leu Gln Lys Glu Leu Asp 
145                 150                 155                 160 


Val Lys Arg Ile Lys Phe Leu Phe Pro Lys Ile Asn Asn Ser Ser Lys 
                165                 170                 175     


Ser Ile Leu Arg Arg Leu Met Asp Gly Thr Tyr Lys Gln Gly Thr Ile 
            180                 185                 190         


Gln Met Lys His Asp Ala Arg Lys Asn Lys Trp Phe Met Ser Ile Thr 
        195                 200                 205             


Phe Thr Phe Asp Asn Lys Ile Asp Lys Thr Leu Asp Glu Asn Leu Val 
    210                 215                 220                 


Met Gly Ile Asp Leu Gly Ile Ser Lys Val Ala Thr Met Ser Ile Tyr 
225                 230                 235                 240 


Asn Ile Glu Lys His Glu Tyr Lys Glu Met Tyr Trp Lys Glu Arg Thr 
                245                 250                 255     


Ile Asp Gly Ala Glu Leu Ile His Tyr Arg Gln Lys Leu Glu Ala Arg 
            260                 265                 270         


Arg Lys Ala Leu Met Ile Ser Ser Lys Trp Ser Ser Asn Asn Ala Ile 
        275                 280                 285             


Gly His Gly Tyr Lys Arg Arg Thr Val Lys Ala Asn Glu Leu Gly Glu 
    290                 295                 300                 


Lys Tyr Thr Arg Phe Arg Asp Thr Tyr Asn His Lys Ile Ser Arg Tyr 
305                 310                 315                 320 


Ile Val Asp Leu Ala Phe Lys Tyr Gly Val Lys Thr Ile Gln Met Glu 
                325                 330                 335     


Asn Leu Ser Gly Phe Ser Thr Glu Gln Ser Glu Ser Leu Leu Lys Asn 
            340                 345                 350         


Trp Ser Tyr Tyr Asp Leu Gln Ser Lys Ile Glu Tyr Lys Ser Lys Asp 
        355                 360                 365             


Lys Gly Ile Asn Val Val Phe Ile Asn Pro Lys Phe Thr Ser Lys Arg 
    370                 375                 380                 


Cys Asn Arg Cys Gly Asn Ile Arg Ser Glu Asn Arg Ser Cys Lys Asn 
385                 390                 395                 400 


Asp Gln Ala Lys Phe Lys Cys Val Val Cys Gly His Glu Asp Asn Ala 
                405                 410                 415     


Asp Ile Asn Ala Ser Lys Asn Ile Ala Ile Pro Tyr Ile Asp Lys Ile 
            420                 425                 430         


Ile Asp Glu Tyr Leu Lys Glu Lys Glu Glu Val Ile 
        435                 440                 


<210>  310
<211>  445
<212>  PRT
<213>  Bacillus cereus

<400>  310

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Leu 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Asp Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Leu Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Ser Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Ile Arg Gln Arg Arg Ile Asn Leu Leu Lys Gln Ser Lys Tyr 
            260                 265                 270         


Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg Thr Lys Arg Leu Gln Pro 
        275                 280                 285             


Ile Asp Val Leu Ser Asn Lys Ile Ala Lys Phe Arg Asn Ser Thr Asn 
    290                 295                 300                 


His Lys Tyr Ala Asn Tyr Ile Val Lys Gln Cys Leu Lys His Asn Cys 
305                 310                 315                 320 


Gly Arg Ile Gln Met Glu Leu Leu Lys Gly Ile Ser Lys Asn Asp Arg 
                325                 330                 335     


Ile Leu Lys Asp Trp Thr Tyr Phe Asp Leu Gln Glu Lys Ile Lys Asn 
            340                 345                 350         


Gln Ala Glu Ile His Gly Ile Glu Val Ile Lys Val Ala Pro Ala Tyr 
        355                 360                 365             


Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr Ile Cys Lys Glu Asn Arg 
    370                 375                 380                 


Cys Thr Gln Ala Thr Phe Glu Cys Lys Gln Cys Gly Tyr Lys Thr His 
385                 390                 395                 400 


Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser Thr Tyr Asp Ile Glu Asn 
                405                 410                 415     


Ile Ile Asn Lys Gln Leu Ala Val Gln Ser Lys Leu His Ser Lys Lys 
            420                 425                 430         


Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly Tyr Leu Asp 
        435                 440                 445 


<210>  311
<211>  445
<212>  PRT
<213>  Bacillus toyonensis

<400>  311

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Leu 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Asp Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Leu Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Ile Arg Gln Arg Arg Ile Asn Leu Leu Lys Gln Ser Lys Tyr 
            260                 265                 270         


Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg Thr Lys Arg Leu Gln Pro 
        275                 280                 285             


Ile Asp Val Leu Ser Asn Lys Ile Ala Lys Phe Arg Asn Ser Thr Asn 
    290                 295                 300                 


His Lys Tyr Ala Asn Tyr Ile Val Lys Gln Cys Leu Lys His Asn Cys 
305                 310                 315                 320 


Gly Arg Ile Gln Met Glu Leu Leu Lys Gly Ile Ser Lys Asn Asp Arg 
                325                 330                 335     


Ile Leu Lys Asp Trp Thr Tyr Phe Asp Leu Gln Glu Lys Ile Lys Asn 
            340                 345                 350         


Gln Ala Glu Ile His Gly Ile Glu Val Ile Lys Val Ala Pro Ala Tyr 
        355                 360                 365             


Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr Ile Cys Lys Glu Asn Arg 
    370                 375                 380                 


Cys Thr Gln Ala Thr Phe Glu Cys Lys Gln Cys Gly Tyr Lys Thr His 
385                 390                 395                 400 


Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser Thr Tyr Asp Ile Glu Asn 
                405                 410                 415     


Ile Ile Asn Lys Gln Leu Ala Val Gln Ser Lys Leu His Ser Lys Lys 
            420                 425                 430         


Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly Tyr Leu Asp 
        435                 440                 445 


<210>  312
<211>  445
<212>  PRT
<213>  Bacillus toyonensis

<400>  312

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Leu 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Asp Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Leu Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Ser Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Ile Arg Gln Arg Arg Ile Asn Leu Leu Lys Gln Ser Lys Tyr 
            260                 265                 270         


Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg Thr Lys Arg Leu Gln Pro 
        275                 280                 285             


Ile Asp Val Leu Ser Asn Lys Ile Ala Lys Phe Arg Asn Ser Thr Asn 
    290                 295                 300                 


His Lys Tyr Ala Asn Tyr Ile Val Lys Gln Cys Leu Lys His Asn Cys 
305                 310                 315                 320 


Gly Arg Ile Gln Met Glu Leu Leu Lys Gly Ile Ser Lys Asn Asp Arg 
                325                 330                 335     


Ile Leu Lys Asp Trp Thr Tyr Phe Asp Leu Gln Glu Lys Ile Lys Asn 
            340                 345                 350         


Gln Val Glu Ile His Gly Ile Glu Val Ile Lys Val Ala Pro Ala Tyr 
        355                 360                 365             


Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr Ile Cys Lys Glu Asn Arg 
    370                 375                 380                 


Cys Thr Gln Ala Thr Phe Glu Cys Lys Gln Cys Gly Tyr Lys Thr His 
385                 390                 395                 400 


Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser Thr Tyr Asp Ile Glu Asn 
                405                 410                 415     


Ile Ile Asn Lys Gln Leu Ala Val Gln Ser Lys Leu His Ser Lys Lys 
            420                 425                 430         


Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly Tyr Leu Asp 
        435                 440                 445 


<210>  313
<211>  445
<212>  PRT
<213>  Bacillus toyonensis

<400>  313

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Leu 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Asp Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Leu Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Ser Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Ile Arg Gln Arg Arg Ile Asn Leu Leu Lys Gln Ser Lys Tyr 
            260                 265                 270         


Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg Thr Lys Arg Leu Gln Pro 
        275                 280                 285             


Ile Asp Val Leu Ser Asn Lys Ile Ala Lys Phe Arg Asn Ser Thr Asn 
    290                 295                 300                 


His Lys Tyr Thr Asn Tyr Ile Val Lys Gln Cys Leu Lys His Asn Cys 
305                 310                 315                 320 


Gly Arg Ile Gln Met Glu Leu Leu Lys Gly Ile Ser Lys Asn Asp Arg 
                325                 330                 335     


Ile Leu Lys Asp Trp Thr Tyr Phe Asp Leu Gln Glu Lys Ile Lys Asn 
            340                 345                 350         


Gln Ala Glu Ile His Gly Ile Glu Val Ile Lys Val Ala Pro Ala Tyr 
        355                 360                 365             


Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr Ile Cys Lys Glu Asn Arg 
    370                 375                 380                 


Cys Thr Gln Ala Thr Phe Glu Cys Lys Gln Cys Gly Tyr Lys Thr His 
385                 390                 395                 400 


Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser Thr Tyr Asp Ile Glu Asn 
                405                 410                 415     


Ile Ile Asn Lys Gln Leu Ala Val Gln Ser Lys Leu His Ser Lys Lys 
            420                 425                 430         


Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly Tyr Leu Asp 
        435                 440                 445 


<210>  314
<211>  447
<212>  PRT
<213>  Alicyclobacillus acidoterrestris

<400>  314

Met Ile Val Lys Thr Met Pro Tyr Glu Ile Ile Lys Pro Leu Ser Cys 
1               5                   10                  15      


Asp Trp Ala Val Phe Gly Glu Met Leu Arg Arg Leu Arg Asp Glu Ser 
            20                  25                  30          


Phe Arg Ile Lys Asn Ser Ala Ile Gln Tyr Phe Tyr Glu Asp Asp Ile 
        35                  40                  45              


Lys Arg Arg Glu Phe Lys Lys Asn Asn Gly Arg Phe Pro Lys Lys Gly 
    50                  55                  60                  


Glu Phe Tyr Gly Ser Ser Val Ser Val Tyr Asn Tyr Val Arg Pro Asp 
65                  70                  75                  80  


Val Lys Tyr Ser Ala Met Gly Asn Val Thr Leu Ile Asn Gln Leu Val 
                85                  90                  95      


Lys Ser Val Trp Ile Lys Tyr Lys Asp Asp Val Val Lys Arg Asn Met 
            100                 105                 110         


Ser Ile Pro Ser Tyr Arg Pro Asn Asn Pro Ile Glu Ile Asn Val Gln 
        115                 120                 125             


Ser Phe Asn Ser Phe Asp Phe Gly Gln Ala Cys Val Asn Leu Leu Ser 
    130                 135                 140                 


Arg Lys Gly Val Glu Glu Leu Lys Lys Lys Leu Ser Glu Val Lys Lys 
145                 150                 155                 160 


Lys Lys Asn Lys Thr Gly Gly Asp Asp Asn Leu Lys Phe Thr Gln Glu 
                165                 170                 175     


Gln Leu Asn Gly Ile Ser Thr Ser Val Thr Phe Ala Phe Asn Pro Gly 
            180                 185                 190         


Lys Asn Asn Ala Lys Gln Val Leu Asn Arg Ile Ile Ser Gly Glu Tyr 
        195                 200                 205             


Lys Leu Ser Ser Ser Lys Ile Ile Tyr Asn Glu Arg Lys Asn Lys Trp 
    210                 215                 220                 


Met Leu Ala Val Ala Tyr Lys Phe Glu Pro Lys Thr Ile Glu Leu Asp 
225                 230                 235                 240 


Lys Asn Arg Val Leu Gly Ile Asp Met Gly Val Val Tyr Pro Ala Tyr 
                245                 250                 255     


Met Ala Val Asn Tyr Asp Lys Tyr Trp Arg Asp Ser Ile Asp Gly Gly 
            260                 265                 270         


Gln Ile Glu Gln Tyr Arg Lys Thr Val Glu Ala Arg Arg Arg Arg Leu 
        275                 280                 285             


Gln Arg Gln Ala Ala Val Cys Gly Asn Gly Arg Ile Gly His Gly Arg 
    290                 295                 300                 


Lys Lys Arg Met Gln Pro Leu Glu Lys Ile Ser Asp Lys Val Ala Asn 
305                 310                 315                 320 


Phe Arg Asn Thr Val Asn His Thr Tyr Ala Lys Lys Ile Val Gln Asn 
                325                 330                 335     


Ala Val Lys Leu Gly Cys Gly Thr Ile Gln Met Glu Glu Leu Ser Gly 
            340                 345                 350         


Ile Asn Glu Lys Glu Thr Phe Leu Lys Arg Trp Thr Tyr Phe Asp Leu 
        355                 360                 365             


Gln Lys Lys Ile Glu Tyr Arg Ala Lys Glu Tyr Gly Ile Asp Val Ile 
    370                 375                 380                 


Lys Ile Asn Pro Lys Tyr Thr Ser Gln Arg Cys Ser Glu Cys Gly Tyr 
385                 390                 395                 400 


Ile Asp Glu Arg Asn Arg Pro Lys Val Pro Asp Gln Ser Lys Phe Lys 
                405                 410                 415     


Cys Leu Ser Cys Gly Tyr Glu Thr Asn Ala Asp Phe Asn Ala Ala Arg 
            420                 425                 430         


Asn Ile Ala Thr Pro Tyr Ile Asp Lys Ile Ile Ser Leu Asn Ser 
        435                 440                 445         


<210>  315
<211>  447
<212>  PRT
<213>  Clostridium tetani

<400>  315

Met Asn Lys Cys Ile Lys Val Glu Leu Lys Ser Cys Leu Glu Lys Asn 
1               5                   10                  15      


Leu Ser Asn Lys Gln Ser Gln Lys Phe Leu Lys Asp Ile Gln Tyr Leu 
            20                  25                  30          


Ser Trp Lys Gly Cys Asn Arg Ala Ile Thr Tyr Leu Tyr Asn His Asp 
        35                  40                  45              


Met Lys Asn Ser Glu Leu Lys Tyr Lys Asn Leu Pro Lys Ile Asp Pro 
    50                  55                  60                  


Asn Lys Glu Tyr Gly Lys Ser Leu Gly Ser Trp Ile Glu Asp Lys Leu 
65                  70                  75                  80  


Lys Glu Ile Met Val Gly Cys Leu Thr Thr Asn Val Ala Gln Thr Arg 
                85                  90                  95      


Ala Phe Val Met Asn Arg Tyr Lys Gln Asp Lys Lys Gln Gly Leu Leu 
            100                 105                 110         


Lys Gly Asn Val Ser Leu Ser Asn Phe Lys Arg Asn Met Pro Ile Ile 
        115                 120                 125             


Ile His Asn Lys Ala Tyr Lys Ile Ile Lys Asp Asp Lys Gly Tyr Ile 
    130                 135                 140                 


Ala Glu Ile Gly Leu Phe Asn Leu Ile Lys Gln Lys Glu Leu Gly Ile 
145                 150                 155                 160 


Lys Arg Leu Thr Phe Arg Ile Asn Lys Leu Asp Gly Asn Lys Lys Ser 
                165                 170                 175     


Thr Leu Asn Lys Ile Ile Asn Glu Asp Tyr Lys Leu Gly Ser Gly Gln 
            180                 185                 190         


Ile Lys Gln Asp Ser Lys Gly Lys Trp Tyr Leu Leu Ile Ser Tyr Ser 
        195                 200                 205             


Phe Lys Asn Glu Ile Val Glu Gly Leu Asp Lys Asp Lys Ile Leu Gly 
    210                 215                 220                 


Ile Asp Leu Gly Ile Val Asn Thr Val Ala Met Ser Ile Tyr Asn Ile 
225                 230                 235                 240 


Lys Lys Asp Thr Trp Glu Gln Thr Arg Tyr Lys Asp Thr Val Ile Asp 
                245                 250                 255     


Gly Glu Glu Leu Ile His Phe Arg Lys Lys Ile Glu Ala Arg Lys Lys 
            260                 265                 270         


Ser Leu Ser Ile Gly Ser Lys Tyr Cys Gly Asp Gly Arg Ile Gly His 
        275                 280                 285             


Gly Tyr Lys Thr Arg Met Lys Pro Phe Leu Asn Ile Lys Asp Lys Ile 
    290                 295                 300                 


Ser Lys Phe Arg Asp Thr Tyr Asn His Lys Ile Ser Arg Tyr Ile Ile 
305                 310                 315                 320 


Asp Phe Ala Ile Lys Asn Lys Cys Gly Ala Ile Gln Met Glu Asp Leu 
                325                 330                 335     


Ser Gly Phe Pro Glu Tyr Gln Thr Glu Lys Phe Leu Lys Asp Trp Thr 
            340                 345                 350         


Tyr Tyr Asp Leu Gln Asn Lys Leu Lys Tyr Lys Ala Glu Glu Ile Gly 
        355                 360                 365             


Ile Asp Ile Ile Phe Ile Asn Pro Lys Tyr Thr Ser Gln Arg Cys Ser 
    370                 375                 380                 


Lys Cys Gly Asn Ile Asn Asn Lys Asn Arg Asp Cys Lys Lys Asp Gln 
385                 390                 395                 400 


Ala Lys Phe Gln Cys Ile Ile Cys Gly Tyr Lys Glu Asn Ala Asp Ile 
                405                 410                 415     


Asn Ala Ser Lys Asn Ile Ser Ile Pro Tyr Ile Asp Asp Ile Ile Lys 
            420                 425                 430         


Glu Tyr Leu Lys Glu Asn Asn Ser Ile Lys Val Asp Phe Pro Thr 
        435                 440                 445         


<210>  316
<211>  449
<212>  PRT
<213>  Candidatus Levybacteria bacterium

<400>  316

Met Val Arg Glu Ile Arg Lys Leu Asn Val Ile Asp Lys Val Glu Lys 
1               5                   10                  15      


Lys Lys Val Val Gln Arg Thr Leu Arg Leu Lys Leu Glu Leu Val Asp 
            20                  25                  30          


Lys Gly Ser Lys Asp Arg Ile Asp Lys Ile Val Arg Asp Cys Pro Tyr 
        35                  40                  45              


Ala Ala Asn Gly Ile Ile Asn Gly Gln Trp Phe Asn Asp Tyr Glu Ala 
    50                  55                  60                  


Asp Ala Leu Arg Tyr Arg Val Ile Gly Asn Val Asn Phe Lys Glu Leu 
65                  70                  75                  80  


Thr Asp Cys Glu Lys Glu Glu Tyr Lys Asn Lys Leu Ser Ser Cys Glu 
                85                  90                  95      


Asp Ile Leu Ile Gln Lys Tyr Gly Thr Lys Arg Gln Ala Thr Thr Glu 
            100                 105                 110         


Arg Asp Ile Lys Asn Leu Phe Pro Glu Ile Pro Pro Cys Val Thr Asn 
        115                 120                 125             


Pro Leu Asn Asn Lys Ile Val Ser Thr Tyr Asn Lys Val Lys Gly Asp 
    130                 135                 140                 


Ile Lys Lys Gly Asn Arg Val Leu Ser Thr Phe Lys Lys Asp Met Pro 
145                 150                 155                 160 


Ile Pro Thr Thr Leu Ser Ser Val Val Phe Gly Glu Asp Lys Gly Lys 
                165                 170                 175     


Phe Phe Ile Val Trp Ser Leu Ser Arg Ser Glu Lys Ile Lys Phe Lys 
            180                 185                 190         


Ile Lys Leu Gly Lys Asp Lys Ser Gly Tyr Lys Gln Asp Leu Val Ala 
        195                 200                 205             


Ile Ile Asn Lys Thr Lys Asn Ile Cys Ala Pro Glu Phe Gln Tyr Lys 
    210                 215                 220                 


Lys Arg Asn Phe Tyr Leu Leu Leu Pro Val Lys Asp Glu Val Asn Pro 
225                 230                 235                 240 


His Ser His Leu Phe Asn Asp Arg Val Val Gly Ile Asp Leu Gly Leu 
                245                 250                 255     


Asn Ile Pro Ala Tyr Ala Ser Cys Ile Ser Asn Gly Ser Glu Phe Val 
            260                 265                 270         


Asp Ser Glu His Phe Gly Ser Lys Glu Ser Phe Leu Lys Val Arg Leu 
        275                 280                 285             


Gln Phe Arg Asn Arg Lys Arg Gln Leu Gln Lys Asp Leu Gln Tyr Val 
    290                 295                 300                 


Asn Gly Gly Lys Gly Arg Arg Lys Lys Thr Lys Ala Leu Asp Glu Tyr 
305                 310                 315                 320 


Glu Phe Lys Glu Arg Asn Tyr Cys Arg Thr Tyr Asn His Asn Leu Thr 
                325                 330                 335     


Ser Lys Ile Ile Asp Phe Ala Ile Lys Cys Gly Ala Lys His Ile Asn 
            340                 345                 350         


Leu Glu Ser Leu Lys Gly Phe Arg Glu Lys Lys Ile Leu Gly Phe Trp 
        355                 360                 365             


Ser Tyr Phe Glu Met Gln Thr Leu Leu Glu Tyr Lys Ala Lys Arg Asn 
    370                 375                 380                 


Asn Ile Glu Val His Phe Val Ser Ala Asn Tyr Thr Ser Gln Thr Cys 
385                 390                 395                 400 


Ser Gln Cys Gly Asn Cys Asp Lys Thr Gln Arg Lys Gly Val Asn Phe 
                405                 410                 415     


Thr Cys Asn Lys Cys Gly Tyr Val Glu Asp Ala Asp Phe Asn Ala Ser 
            420                 425                 430         


Ile Asn Ile Ala Lys Ser Ile Gln Phe Val Ala Asn Lys Lys Ala Ser 
        435                 440                 445             


Lys 
    


<210>  317
<211>  450
<212>  PRT
<213>  Bacillus cereus

<400>  317

Met Ser Thr Val Val Lys Val Met Lys Tyr Gln Ile Val Cys Pro Val 
1               5                   10                  15      


Asn Ile Glu Trp Lys Thr Phe Glu Ile Tyr Leu Arg Thr Leu Ser Tyr 
            20                  25                  30          


His Phe Arg Thr Ile Gly Asn Arg Thr Ile Gln Lys Leu Trp Glu Tyr 
        35                  40                  45              


Asp Asn Gln Ser Leu Lys His Phe Lys Asp Thr Gly Gln Tyr Pro Ser 
    50                  55                  60                  


Ala Gln Gln Leu Tyr Gly Cys Thr Gln Lys Thr Ile Ser Gly Tyr Ile 
65                  70                  75                  80  


Tyr Asp Gln Leu Lys Glu Glu Tyr Gln Asp Ile Asn Lys Ala Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Thr Ile Lys Thr Trp Asn Ser Arg Lys Lys 
            100                 105                 110         


Glu Ile Trp Ser Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Asn Leu 
        115                 120                 125             


Pro Ile Asp Ile His Gly Asn Ser Ile Gln Ile Ile Lys Glu Lys Ser 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Ser Val Ser Leu Phe Ser Ser Lys Phe Ile Lys 
145                 150                 155                 160 


Glu Asn Asp Leu Pro Asn Gly Lys Ile Leu Val Lys Leu Ser Thr Arg 
                165                 170                 175     


Lys Gln Asn Ser Met Lys Val Ile Leu Asp Arg Ile Ile Asp Ser Thr 
            180                 185                 190         


Tyr Ala Lys Gly Ala Cys Met Leu His Lys His Lys Lys Lys Trp Tyr 
        195                 200                 205             


Leu Ser Ile Thr Tyr Lys Ser Asn Ile Lys Glu Glu Leu Lys Phe Asp 
    210                 215                 220                 


Glu Asp Leu Ile Met Gly Ile Asp Met Gly Lys Ile Asn Val Leu Tyr 
225                 230                 235                 240 


Phe Ala Phe Asn Lys Gly Leu Val Arg Gly Gly Ile Ser Gly Glu Glu 
                245                 250                 255     


Ile Glu Ala Phe Arg Lys Lys Ile Glu His Arg Arg Ile Ser Leu Leu 
            260                 265                 270         


Arg Gln Gly Lys Tyr Cys Ser Gly Asn Arg Ile Gly Lys Gly Arg Lys 
        275                 280                 285             


Lys Arg Ile Lys Pro Ile Glu Val Leu Asn Asp Lys Ile Ala Lys Phe 
    290                 295                 300                 


Arg Asn Ala Thr Asn His Lys Tyr Ala Asn Tyr Ile Val Gln Gln Cys 
305                 310                 315                 320 


Leu Lys Tyr Asn Cys Gly Thr Ile Gln Leu Glu Asp Leu Gln Gly Ile 
                325                 330                 335     


Ser Lys Glu Gln Thr Phe Leu Lys Asn Trp Thr Tyr Phe Asp Leu Gln 
            340                 345                 350         


Glu Lys Ile Lys Asn Gln Ala Asn Gln Tyr Gly Ile Lys Val Val Lys 
        355                 360                 365             


Ile Asp Pro Ser Tyr Thr Ser Gln Arg Cys Ser Glu Cys Gly Tyr Ile 
    370                 375                 380                 


His Lys Asn Asn Arg Gln Asn Gln Ser Thr Phe Glu Cys Gln Gln Cys 
385                 390                 395                 400 


Ser Phe Lys Val His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser Val 
                405                 410                 415     


Tyr Asn Ile Glu Lys Val Ile Gln Lys Gln Leu Lys Leu Gln Glu Lys 
            420                 425                 430         


Leu Asn Leu Thr Lys Tyr Lys Glu Gln Tyr Ile Glu Gln Met Glu Asn 
        435                 440                 445             


Ile Asn 
    450 


<210>  318
<211>  450
<212>  PRT
<213>  Bacillus cereus

<400>  318

Met Ser Ile Ala Val Lys Val Met Lys Tyr Gln Ile Val Cys Pro Val 
1               5                   10                  15      


Asn Ile Glu Trp Lys Thr Phe Glu Ile Tyr Leu Arg Thr Leu Ser Tyr 
            20                  25                  30          


His Phe Arg Thr Ile Gly Asn Arg Thr Ile Gln Lys Leu Trp Glu Tyr 
        35                  40                  45              


Asp Asn Gln Ser Leu Lys His Phe Lys Asp Thr Gly Gln Tyr Pro Ser 
    50                  55                  60                  


Ala Gln Gln Leu Tyr Gly Cys Thr Gln Lys Thr Ile Ser Gly Tyr Ile 
65                  70                  75                  80  


Tyr Asp Gln Leu Lys Glu Glu Tyr Gln Asp Ile Asn Lys Ala Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Thr Ile Lys Thr Trp Asn Ser Arg Lys Lys 
            100                 105                 110         


Glu Ile Trp Ser Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Asn Leu 
        115                 120                 125             


Pro Ile Asp Ile His Gly Asn Ser Ile Gln Ile Ile Lys Glu Lys Ser 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Ser Val Ser Leu Phe Ser Ser Lys Phe Ile Lys 
145                 150                 155                 160 


Glu Asn Asp Leu Pro Asn Gly Lys Ile Leu Val Lys Leu Ser Thr Arg 
                165                 170                 175     


Lys Gln Asn Ser Met Lys Val Ile Leu Asp Arg Ile Ile Asp Ser Thr 
            180                 185                 190         


Tyr Ala Lys Gly Ala Cys Met Leu His Lys His Lys Lys Lys Trp Tyr 
        195                 200                 205             


Leu Ser Ile Thr Tyr Lys Ser Asn Ile Lys Glu Glu Leu Lys Phe Asp 
    210                 215                 220                 


Glu Asp Leu Ile Met Gly Ile Asp Met Gly Lys Ile Asn Val Leu Tyr 
225                 230                 235                 240 


Phe Ala Phe Asn Lys Gly Leu Val Arg Gly Ala Ile Ser Gly Glu Glu 
                245                 250                 255     


Ile Glu Ala Phe Arg Lys Lys Ile Glu His Arg Arg Ile Ser Leu Leu 
            260                 265                 270         


Arg Gln Gly Lys Tyr Cys Ser Gly Asn Arg Ile Gly Lys Gly Arg Lys 
        275                 280                 285             


Lys Arg Ile Lys Pro Ile Glu Val Leu Asn Asp Lys Ile Ala Lys Phe 
    290                 295                 300                 


Arg Asn Ala Thr Asn His Lys Tyr Ala Asn Tyr Ile Val Gln Gln Cys 
305                 310                 315                 320 


Leu Lys Tyr Asn Cys Gly Thr Ile Gln Leu Glu Asp Leu Gln Gly Ile 
                325                 330                 335     


Ser Lys Glu Gln Thr Phe Leu Lys Asn Trp Thr Tyr Phe Asp Leu Gln 
            340                 345                 350         


Glu Lys Ile Lys Asn Leu Ala Asn Gln Tyr Gly Ile Lys Val Val Lys 
        355                 360                 365             


Ile Asp Pro Ser Tyr Thr Ser Gln Arg Cys Ser Glu Cys Gly Tyr Ile 
    370                 375                 380                 


His Lys Asn Asn Arg Gln Asn Gln Ser Thr Phe Glu Cys Gln Gln Cys 
385                 390                 395                 400 


Ser Phe Lys Val His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser Val 
                405                 410                 415     


Tyr Asn Ile Glu Lys Val Ile Gln Lys Gln Leu Lys Leu Gln Glu Lys 
            420                 425                 430         


Leu Asn Leu Thr Lys Tyr Lys Glu Gln Tyr Ile Glu Gln Met Glu Asn 
        435                 440                 445             


Ile Asn 
    450 


<210>  319
<211>  450
<212>  PRT
<213>  Bacillus cereus

<400>  319

Met Ser Ile Ala Val Lys Val Met Lys Tyr Gln Ile Val Cys Pro Val 
1               5                   10                  15      


Asn Ile Glu Trp Lys Thr Phe Glu Ile Tyr Leu Arg Thr Leu Ser Tyr 
            20                  25                  30          


His Phe Arg Thr Ile Gly Asn Arg Thr Ile Gln Lys Leu Trp Glu Tyr 
        35                  40                  45              


Asp Asn Gln Ser Leu Lys His Phe Lys Asp Thr Gly Gln Tyr Pro Ser 
    50                  55                  60                  


Ala Gln Gln Leu Tyr Gly Cys Thr Gln Lys Thr Ile Ser Gly Tyr Ile 
65                  70                  75                  80  


Tyr Asp Gln Leu Lys Glu Glu Tyr Gln Asp Ile Asn Lys Ala Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Thr Ile Lys Thr Trp Asn Ser Arg Lys Lys 
            100                 105                 110         


Glu Ile Trp Ser Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Asn Leu 
        115                 120                 125             


Pro Ile Asp Ile His Gly Asn Ser Ile Gln Ile Ile Lys Glu Lys Ser 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Ser Val Ser Leu Phe Ser Ser Lys Phe Ile Lys 
145                 150                 155                 160 


Glu Asn Asp Leu Pro Asn Gly Lys Ile Leu Val Lys Leu Ser Thr Arg 
                165                 170                 175     


Lys Gln Asn Ser Met Lys Val Ile Leu Asp Arg Ile Ile Asp Ser Thr 
            180                 185                 190         


Tyr Ala Lys Gly Ala Cys Met Leu His Lys His Lys Lys Lys Trp Tyr 
        195                 200                 205             


Leu Ser Ile Thr Tyr Lys Ser Asn Ile Lys Glu Glu Leu Lys Phe Asp 
    210                 215                 220                 


Glu Asp Leu Ile Met Gly Ile Asp Met Gly Lys Ile Asn Val Leu Tyr 
225                 230                 235                 240 


Phe Ala Phe Asn Lys Gly Leu Val Arg Gly Ala Ile Ser Gly Glu Glu 
                245                 250                 255     


Ile Glu Ala Phe Arg Lys Lys Ile Glu His Arg Arg Ile Ser Leu Leu 
            260                 265                 270         


Arg Gln Gly Lys Tyr Cys Ser Gly Asn Arg Ile Gly Lys Gly Arg Lys 
        275                 280                 285             


Lys Arg Ile Lys Pro Ile Glu Val Leu Asn Asp Lys Ile Ala Lys Phe 
    290                 295                 300                 


Arg Thr Ala Thr Asn His Lys Tyr Ala Asn Tyr Ile Val Gln Gln Cys 
305                 310                 315                 320 


Leu Lys Phe Asn Cys Gly Thr Ile Gln Leu Glu Asp Leu Gln Gly Ile 
                325                 330                 335     


Ser Lys Glu Gln Thr Phe Leu Lys Asn Trp Thr Tyr Phe Asp Leu Gln 
            340                 345                 350         


Glu Lys Ile Lys Asn Gln Ala Asn Gln Tyr Gly Ile Lys Val Val Lys 
        355                 360                 365             


Ile Asp Pro Ser Tyr Thr Ser Gln Arg Cys Ser Glu Cys Gly Cys Ile 
    370                 375                 380                 


His Lys Asn Asn Arg Gln Asn Gln Ser Thr Phe Glu Cys Gln Gln Cys 
385                 390                 395                 400 


Ser Phe Lys Val His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser Val 
                405                 410                 415     


Tyr Asn Ile Glu Lys Val Ile Gln Lys Gln Leu Lys Leu Gln Glu Lys 
            420                 425                 430         


Leu Asn Leu Thr Lys Tyr Lys Glu Gln Tyr Ile Glu Gln Met Glu Asn 
        435                 440                 445             


Ile Asn 
    450 


<210>  320
<211>  450
<212>  PRT
<213>  Clostridium paraputrificum

<400>  320

Met Lys Leu Asn Lys Cys Ile Lys Val Thr Leu Val Lys Cys Leu Asn 
1               5                   10                  15      


Tyr Asp Tyr Lys Glu Ile Lys Gln Ile Ile Arg Asp Phe Asn Tyr Thr 
            20                  25                  30          


Ala Cys Lys Ala Ser Asn Lys Ala Met Arg Met Trp Phe Phe His Thr 
        35                  40                  45              


Gln Asp Met Ile Asp Lys Lys Asn Lys Tyr Lys Glu Phe Asn Gln Ile 
    50                  55                  60                  


Gln Tyr Glu Lys Asp Thr Tyr Gly Lys Ser Tyr Arg Asn Val Ile Glu 
65                  70                  75                  80  


Gly Glu Met Lys Lys Ile Met Pro Leu Ala Asn Thr Ser Asn Val Gly 
                85                  90                  95      


Thr Leu His Gln Gln Leu Val Gln Asn Asp Trp Ser Arg Leu Lys Lys 
            100                 105                 110         


Asp Ile Leu Ser Cys Lys Ala Asn Leu Pro Thr Tyr Lys Leu Ser Thr 
        115                 120                 125             


Pro Tyr Phe Ile Lys Asn Asp Asn Phe Lys Leu Arg Asn His Asn Gly 
    130                 135                 140                 


Tyr Phe Val Asp Ile Ala Phe Phe Asn Lys Glu Gly Leu Lys Gln Tyr 
145                 150                 155                 160 


Gly Tyr Lys Ala Gly His Lys Phe Glu Phe Gln Ile Asp Lys Leu Asp 
                165                 170                 175     


Gly Asn Lys Lys Ser Thr Ile Asn Lys Ile Ile Asn Gly Glu Tyr Lys 
            180                 185                 190         


Gln Gly Ser Ala Gln Leu Ser Ile Ser Asn Lys Gly Lys Ile Glu Leu 
        195                 200                 205             


Ile Ile Ser Tyr Ser Phe Glu Lys Glu Glu Val Pro Val Leu Asp Lys 
    210                 215                 220                 


Asn Lys Ile Leu Gly Ile Asp Leu Gly Ile Thr Asn Val Ala Thr Met 
225                 230                 235                 240 


Ser Val Tyr Asp Ser Met Arg Glu Gln Tyr Asp Tyr Phe Ser Trp Lys 
                245                 250                 255     


Thr Asn Val Ile Ser Gly Lys Glu Leu Ile Ala Phe Arg Gln Lys Tyr 
            260                 265                 270         


Tyr Asn Leu Arg Arg Asp Met Ser Ile Ala Ser Lys Thr Ala Gly Gln 
        275                 280                 285             


Gly Arg Cys Gly His Gly Tyr Lys Thr Lys Met Lys Ser Val Asn Lys 
    290                 295                 300                 


Val Arg Asn Lys Ile Ala Asn Phe Ala Asp Thr Tyr Asn His Lys Ile 
305                 310                 315                 320 


Ser Lys Tyr Ile Ile Glu Phe Ala Ile Lys Asn Asn Cys Gly Val Ile 
                325                 330                 335     


Gln Val Glu Asp Leu Ser Gly Ala Thr Ala Asp Thr His Asn Lys Met 
            340                 345                 350         


Leu Lys Asp Trp Ser Tyr Tyr Asp Leu Gln Gln Lys Ile Glu Tyr Lys 
        355                 360                 365             


Ala Lys Glu Gln Gly Ile Glu Val Ile Lys Val Asn Pro Lys Tyr Thr 
    370                 375                 380                 


Ser Lys Arg Cys Ser Lys Cys Gly Cys Ile His Glu Asp Asn Arg Asp 
385                 390                 395                 400 


Cys Arg Asn Asn Gln Ala Lys Phe Glu Cys Lys Val Cys Gly Tyr Asn 
                405                 410                 415     


Glu Asn Ala Asp Ile Asn Ala Ser Lys Asn Ile Ala Ile Pro Asp Ile 
            420                 425                 430         


Asp Asn Ile Ile Lys Gly Thr Glu Ile Leu His Ser Lys Glu Asn Lys 
        435                 440                 445             


Ala Ser 
    450 


<210>  321
<211>  451
<212>  PRT
<213>  Bacillus cereus

<400>  321

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Ile Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Gly Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Gly Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Met Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Val Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile Tyr Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Val Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Met Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  322
<211>  451
<212>  PRT
<213>  Bacillus thuringiensis

<400>  322

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Ile Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Asp Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ser Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Met Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Ile Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Val Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Ile Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Ile Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Val Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Ile Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  323
<211>  451
<212>  PRT
<213>  Bacillus cereus

<400>  323

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Ala Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Asp Asp Val Pro Lys Gly Lys Ile Phe Ile Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Thr Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Ile Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Met Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Ala Glu Tyr Met Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  324
<211>  451
<212>  PRT
<213>  Bacillus toyonensis

<400>  324

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Asp Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Leu Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Met Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Val Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Arg Ile Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Thr Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  325
<211>  451
<212>  PRT
<213>  Bacillus cereus

<400>  325

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Ala Ile Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Lys Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Ser Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Lys Lys Gln Lys Ser Met Lys Ile Ile Leu Asp Arg Leu Met Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Asn Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Ala Phe Asn Glu Lys Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Asn Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Ala Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Ile Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Val His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Ala Ser Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Val Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ala 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  326
<211>  451
<212>  PRT
<213>  Bacillus toyonensis

<400>  326

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Ile Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Ile Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Asp Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Lys Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Glu Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Asn Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys Tyr Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Met Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ala 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Ala Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  327
<211>  451
<212>  PRT
<213>  Bacillus wiedmannii

<400>  327

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Ala Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Asp Asp Val Pro Lys Gly Lys Ile Phe Ile Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Thr Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Met Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Ile Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Met Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Ala Glu Tyr Met Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  328
<211>  451
<212>  PRT
<213>  Bacillus cereus

<400>  328

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Ser 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Ile Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Gly Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Met Ser Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Cys Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Asp Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Ala Phe Asn Glu Lys Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Asn Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Ala Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Ile Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Gly Asn Arg Cys Thr Gln Ala Ile Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr Asn Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ala 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Ala Gln Ser 
            420                 425                 430         


Lys Leu Asn Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  329
<211>  451
<212>  PRT
<213>  Bacillus cereus

<400>  329

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Ala Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Glu Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Gly Asp Val Pro Lys Gly Lys Ile Phe Leu Lys Leu Gly Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Ala Phe Asn Glu Lys Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Asn Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Ala Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Ile Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Met Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  330
<211>  451
<212>  PRT
<213>  Bacillus toyonensis

<400>  330

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Leu Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Gly Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ser Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Met Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Met Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Ile Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Val Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Ile Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Gly Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Ile Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Val Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Ile Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  331
<211>  451
<212>  PRT
<213>  Bacillus cereus

<400>  331

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Lys Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Ser Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Lys Lys Gln Lys Ser Met Lys Ile Ile Leu Asp Arg Leu Met Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Asp Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Ala Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Glu Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Gln Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Val Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ala 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  332
<211>  451
<212>  PRT
<213>  Bacillus toyonensis

<400>  332

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Ile Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Gly Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Gly Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Met Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Val Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Ile Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile Tyr Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Val Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Met Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  333
<211>  451
<212>  PRT
<213>  Bacillus thuringiensis

<400>  333

Met Arg Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Lys Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Leu Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Gly Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Gln Arg Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Ala Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Glu Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Gln Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Val Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ala 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  334
<211>  451
<212>  PRT
<213>  Bacillus cereus

<400>  334

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Gly Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Met Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Leu Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Thr Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Lys Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Thr Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Asn Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Ile Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Asp Met Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Thr Tyr Gly Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Lys Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  335
<211>  451
<212>  PRT
<213>  Bacillus cereus

<400>  335

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asp Tyr Phe Lys Ala Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Thr Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Arg Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Gly Asp Val Pro Lys Gly Lys Ile Phe Leu Lys Leu Gly Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asp Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Ala Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Ala Phe Asn Glu Lys Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Asn Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Ala Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Ile Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Val Ala Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Met Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Glu Glu Tyr Ile Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  336
<211>  451
<212>  PRT
<213>  Bacillus cereus

<400>  336

Met Gly Val Thr Ile Lys Ile Met Lys Tyr Gln Ile Leu Cys Pro Met 
1               5                   10                  15      


Asn Val Asp Trp Thr Ile Phe Glu Lys His Leu Arg Asn Leu Thr Tyr 
            20                  25                  30          


Gln Val Arg Thr Ile Ser Asn Arg Thr Ile Gln Gln Leu Trp Glu Phe 
        35                  40                  45              


Asp Ala Leu Ser Phe Asn Tyr Phe Lys Glu Arg Gly Thr Tyr Pro Thr 
    50                  55                  60                  


Val Gln Asp Leu Tyr Gly Cys Thr Gln Lys Lys Ile Asp Gly Tyr Ile 
65                  70                  75                  80  


Tyr His Thr Leu Gln Ser Lys Tyr Pro Asp Ile His Lys Gly Asn Met 
                85                  90                  95      


Ser Ser Thr Leu Gln Lys Ile Ile Lys Thr Trp Lys Ser Arg Lys Asn 
            100                 105                 110         


Glu Ile Arg Lys Gly Glu Met Ser Ile Pro Ser Phe Arg Asn Arg Ile 
        115                 120                 125             


Pro Ile Asp Leu His Asn Asn Ser Val Asp Ile Thr Lys Glu Lys Asn 
    130                 135                 140                 


Gly Asp Tyr Ile Ala Gly Ile Ser Leu Phe Ser Arg Asp Phe His Lys 
145                 150                 155                 160 


Glu Asn Gly Asp Val Pro Lys Gly Lys Ile Phe Val Lys Leu Ala Thr 
                165                 170                 175     


Gln Lys Gln Lys Ser Met Lys Val Ile Leu Asn Arg Leu Ile Asn Gln 
            180                 185                 190         


Thr Tyr Ser Lys Gly Ala Cys Met Ile His Lys Tyr Lys Asn Lys Trp 
        195                 200                 205             


Tyr Leu Ser Ile Thr Tyr Lys Phe Asn Val Ile Lys Glu Asn Lys Phe 
    210                 215                 220                 


Asp Lys Glu Leu Ile Met Gly Ile Asp Met Gly Gly Ile Asn Thr Val 
225                 230                 235                 240 


Tyr Phe Ala Phe Asn Glu Gly Phe Ile Arg Ser Asn Ile Lys Ser Asp 
                245                 250                 255     


Glu Ile Lys Thr Phe Asn Glu Arg Ile Arg Gln Arg Arg Ile Asn Leu 
            260                 265                 270         


Leu Lys Gln Ser Lys Tyr Cys Ser Asn Ser Arg Thr Gly Lys Gly Arg 
        275                 280                 285             


Thr Lys Arg Leu Gln Pro Ile Asp Val Leu Ser Asn Lys Ile Ala Lys 
    290                 295                 300                 


Phe Arg Asn Ser Thr Asn His Lys Tyr Ala Asn Tyr Ile Ile Lys Gln 
305                 310                 315                 320 


Cys Leu Lys His Asn Cys Gly Arg Ile Gln Met Glu Leu Leu Lys Gly 
                325                 330                 335     


Ile Ser Lys Asn Asp Lys Val Leu Lys Asp Trp Thr Tyr Phe Asp Leu 
            340                 345                 350         


Gln Glu Lys Ile Lys Asn Gln Ala Glu Ile His Gly Ile Glu Val Ile 
        355                 360                 365             


Lys Ile Val Pro Ala Tyr Thr Ser Gln Arg Cys Ser Gln Cys Gly Tyr 
    370                 375                 380                 


Ile Cys Lys Glu Asn Arg Cys Thr Gln Ala Met Phe Glu Cys Lys Gln 
385                 390                 395                 400 


Cys Gly Tyr Lys Thr His Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ser 
                405                 410                 415     


Thr Tyr Asp Ile Glu Asn Ile Ile Asn Lys Gln Leu Ala Val Gln Ser 
            420                 425                 430         


Lys Leu His Ser Lys Lys Cys Met Ala Glu Tyr Met Glu Glu Leu Gly 
        435                 440                 445             


Tyr Leu Asp 
    450     


<210>  337
<211>  453
<212>  PRT
<213>  Bacillus thuringiensis

<400>  337

Met Thr Tyr Leu Ser Ile Ala Val Lys Val Met Lys Tyr Gln Ile Val 
1               5                   10                  15      


Cys Pro Val Asn Ile Glu Trp Lys Thr Phe Glu Ile Tyr Leu Arg Thr 
            20                  25                  30          


Leu Ser Tyr His Phe Arg Thr Ile Gly Asn Arg Thr Ile Gln Lys Leu 
        35                  40                  45              


Trp Glu Tyr Asp Asn Gln Ser Leu Lys His Phe Lys Asp Thr Gly Gln 
    50                  55                  60                  


Tyr Pro Ser Ala Gln Gln Leu Tyr Gly Cys Thr Gln Lys Thr Ile Ser 
65                  70                  75                  80  


Gly Tyr Ile Tyr Asp Gln Leu Lys Glu Glu Tyr Gln Asp Ile Asn Lys 
                85                  90                  95      


Ala Asn Met Ser Thr Thr Leu Gln Lys Thr Ile Arg Thr Trp Asn Ser 
            100                 105                 110         


Arg Lys Lys Glu Ile Trp Ser Gly Glu Met Ser Ile Pro Ser Phe Arg 
        115                 120                 125             


Asn Asn Leu Pro Ile Asp Ile His Gly Asn Ser Ile Gln Ile Ile Lys 
    130                 135                 140                 


Glu Lys Ser Gly Asp Tyr Ile Ala Ser Val Ser Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Phe Ile Lys Glu Asn Asp Leu Pro Asn Gly Lys Ile Leu Val Lys Leu 
                165                 170                 175     


Ser Thr Arg Lys Gln Asn Ser Met Lys Val Ile Leu Asp Arg Ile Ile 
            180                 185                 190         


Asp Ser Thr Tyr Ala Lys Gly Ala Cys Met Leu His Lys His Lys Lys 
        195                 200                 205             


Lys Trp Tyr Leu Ser Ile Thr Tyr Lys Ser Asn Ile Lys Glu Glu Leu 
    210                 215                 220                 


Lys Phe Asp Glu Asp Leu Ile Met Gly Ile Asp Met Gly Lys Ile Asn 
225                 230                 235                 240 


Val Leu Tyr Phe Ala Phe Asn Lys Gly Leu Val Arg Gly Ala Ile Ser 
                245                 250                 255     


Gly Glu Glu Ile Glu Ala Phe Arg Lys Lys Ile Glu His Arg Arg Ile 
            260                 265                 270         


Ser Leu Leu Arg Gln Gly Lys Tyr Cys Ser Gly Asn Arg Ile Gly Lys 
        275                 280                 285             


Gly Arg Glu Lys Arg Ile Lys Pro Ile Asp Val Leu Asn Asp Lys Val 
    290                 295                 300                 


Ala Lys Phe Arg Asn Ala Thr Asn His Lys Tyr Ala Asn Tyr Ile Val 
305                 310                 315                 320 


Gln Gln Cys Leu Lys Tyr Asn Cys Gly Thr Ile Gln Leu Glu Asp Leu 
                325                 330                 335     


Lys Gly Ile Ser Lys Glu Gln Thr Phe Leu Lys Asn Trp Thr Tyr Phe 
            340                 345                 350         


Asp Leu Gln Glu Lys Ile Lys Asn Gln Ala Asn Gln Tyr Gly Met Lys 
        355                 360                 365             


Val Val Lys Ile Asp Pro Ser Tyr Thr Ser Gln Arg Cys Ser Glu Cys 
    370                 375                 380                 


Gly Tyr Ile His Lys Asn Asn Arg Gln Asp Gln Ser Thr Phe Glu Cys 
385                 390                 395                 400 


Gln Gln Cys Ser Phe Lys Val His Ala Asp Tyr Asn Ala Ala Lys Asn 
                405                 410                 415     


Ile Ser Val Tyr Asn Ile Glu Lys Val Ile Gln Lys Gln Leu Glu Leu 
            420                 425                 430         


Gln Glu Lys Leu Asn Gln Thr Lys Tyr Lys Glu Gln Tyr Ile Glu Gln 
        435                 440                 445             


Met Lys Asn Ile Asn 
    450             


<210>  338
<211>  453
<212>  PRT
<213>  Bacillus sp.

<400>  338

Met Thr Tyr Leu Ser Thr Val Val Lys Val Met Lys Tyr Gln Ile Val 
1               5                   10                  15      


Cys Pro Val Asn Ile Glu Trp Lys Thr Phe Glu Ile Tyr Leu Arg Thr 
            20                  25                  30          


Leu Ser Tyr His Phe Arg Thr Ile Gly Asn Arg Thr Ile Gln Lys Leu 
        35                  40                  45              


Trp Glu Tyr Asp Asn Gln Ser Leu Lys His Phe Lys Asp Thr Gly Gln 
    50                  55                  60                  


Tyr Pro Ser Ala Gln Gln Leu Tyr Gly Cys Thr Gln Lys Thr Ile Ser 
65                  70                  75                  80  


Gly Tyr Ile Tyr Asp Gln Leu Lys Glu Glu Tyr Gln Asp Ile Asn Lys 
                85                  90                  95      


Ala Asn Met Ser Thr Thr Leu Gln Lys Thr Ile Lys Thr Trp Asn Ser 
            100                 105                 110         


Arg Lys Lys Glu Ile Trp Ser Gly Glu Met Ser Ile Pro Ser Phe Arg 
        115                 120                 125             


Asn Asn Leu Pro Ile Asp Ile His Gly Asn Ser Ile Gln Ile Ile Lys 
    130                 135                 140                 


Glu Lys Ser Gly Asp Tyr Ile Ala Ser Val Ser Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Phe Ile Lys Glu Asn Asp Leu Pro Asn Gly Lys Ile Leu Val Lys Leu 
                165                 170                 175     


Ser Thr Arg Lys Gln Asn Ser Met Lys Val Ile Leu Asp Arg Ile Ile 
            180                 185                 190         


Asp Ser Thr Tyr Ala Lys Gly Ala Cys Met Leu His Lys His Lys Lys 
        195                 200                 205             


Lys Trp Tyr Leu Ser Ile Thr Tyr Lys Ser Asn Ile Lys Glu Glu Leu 
    210                 215                 220                 


Lys Phe Asp Glu Asp Leu Ile Met Gly Ile Asp Met Gly Lys Ile Asn 
225                 230                 235                 240 


Val Leu Tyr Phe Ala Phe Asn Lys Gly Leu Val Arg Gly Gly Ile Ser 
                245                 250                 255     


Gly Glu Glu Ile Glu Ala Phe Arg Lys Lys Ile Glu His Arg Arg Ile 
            260                 265                 270         


Ser Leu Leu Arg Gln Gly Lys Tyr Cys Ser Gly Asn Arg Ile Gly Lys 
        275                 280                 285             


Gly Arg Lys Lys Arg Ile Lys Pro Ile Glu Val Leu Asn Asp Lys Ile 
    290                 295                 300                 


Ala Lys Phe Arg Asn Ala Thr Asn His Lys Tyr Ala Asn Tyr Ile Val 
305                 310                 315                 320 


Gln Gln Cys Leu Lys Tyr Asn Cys Gly Thr Ile Gln Leu Glu Asp Leu 
                325                 330                 335     


Gln Gly Ile Ser Lys Glu Gln Thr Phe Leu Lys Asn Trp Thr Tyr Phe 
            340                 345                 350         


Asp Leu Gln Glu Lys Ile Lys Asn Gln Ala Asn Gln Tyr Gly Ile Lys 
        355                 360                 365             


Val Val Lys Ile Asp Pro Ser Tyr Thr Ser Gln Arg Cys Ser Glu Cys 
    370                 375                 380                 


Gly Tyr Ile His Lys Asn Asn Arg Gln Asn Gln Ser Thr Phe Glu Cys 
385                 390                 395                 400 


Gln Gln Cys Ser Phe Lys Val His Ala Asp Tyr Asn Ala Ala Lys Asn 
                405                 410                 415     


Ile Ser Val Tyr Asn Ile Glu Lys Val Ile Gln Lys Gln Leu Lys Leu 
            420                 425                 430         


Gln Glu Lys Leu Asn Leu Thr Lys Tyr Lys Glu Gln Tyr Ile Glu Gln 
        435                 440                 445             


Met Glu Asn Ile Asn 
    450             


<210>  339
<211>  453
<212>  PRT
<213>  Bacillus cereus

<400>  339

Met Thr Tyr Leu Ser Ile Ala Val Lys Val Met Lys Tyr Gln Ile Val 
1               5                   10                  15      


Cys Pro Val Asn Ile Glu Trp Lys Thr Phe Glu Ile Tyr Leu Arg Thr 
            20                  25                  30          


Leu Ser Tyr His Phe Arg Thr Ile Gly Asn Arg Thr Ile Gln Lys Leu 
        35                  40                  45              


Trp Glu Tyr Asp Asn Gln Ser Leu Lys His Phe Lys Asp Thr Gly Gln 
    50                  55                  60                  


Tyr Pro Ser Ala Gln Gln Leu Tyr Gly Cys Thr Gln Lys Thr Ile Ser 
65                  70                  75                  80  


Gly Tyr Ile Tyr Asp Gln Leu Lys Glu Glu Tyr Gln Asp Ile Asn Lys 
                85                  90                  95      


Ala Asn Met Ser Thr Thr Leu Gln Lys Thr Ile Lys Thr Trp Asn Ser 
            100                 105                 110         


Arg Lys Lys Glu Ile Trp Ser Gly Glu Met Ser Ile Pro Ser Phe Arg 
        115                 120                 125             


Asn Asn Leu Pro Ile Asp Ile His Gly Asn Ser Ile Gln Ile Ile Lys 
    130                 135                 140                 


Glu Lys Ser Gly Asp Tyr Ile Ala Ser Val Ser Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Phe Ile Lys Glu Asn Asp Leu Pro Asn Gly Lys Ile Leu Val Lys Leu 
                165                 170                 175     


Ser Thr Arg Lys Gln Asn Ser Met Lys Val Ile Leu Asp Arg Ile Ile 
            180                 185                 190         


Asp Ser Thr Tyr Ala Lys Gly Ala Cys Met Leu His Lys His Lys Lys 
        195                 200                 205             


Lys Trp Tyr Leu Ser Ile Thr Tyr Lys Ser Asn Ile Lys Glu Glu Leu 
    210                 215                 220                 


Lys Phe Asp Glu Asp Leu Ile Met Gly Ile Asp Met Gly Lys Ile Asn 
225                 230                 235                 240 


Val Leu Tyr Phe Ala Phe Asn Lys Gly Leu Val Arg Gly Ala Ile Ser 
                245                 250                 255     


Gly Glu Glu Ile Glu Ala Phe Arg Lys Lys Ile Glu His Arg Arg Ile 
            260                 265                 270         


Ser Leu Leu Arg Gln Gly Lys Tyr Cys Ser Gly Asn Arg Ile Gly Lys 
        275                 280                 285             


Gly Arg Lys Lys Arg Ile Lys Pro Ile Glu Val Leu Asn Asp Lys Ile 
    290                 295                 300                 


Ala Lys Phe Arg Asn Ala Thr Asn His Lys Tyr Ala Asn Tyr Ile Val 
305                 310                 315                 320 


Gln Gln Cys Leu Lys Tyr Asn Cys Gly Thr Ile Gln Leu Glu Asp Leu 
                325                 330                 335     


Gln Gly Ile Ser Lys Glu Gln Thr Phe Leu Lys Asn Trp Thr Tyr Phe 
            340                 345                 350         


Asp Leu Gln Glu Lys Ile Lys Asn Leu Ala Asn Gln Tyr Gly Ile Lys 
        355                 360                 365             


Val Val Lys Ile Asp Pro Ser Tyr Thr Ser Gln Arg Cys Ser Glu Cys 
    370                 375                 380                 


Gly Tyr Ile His Lys Asn Asn Arg Gln Asn Gln Ser Thr Phe Glu Cys 
385                 390                 395                 400 


Gln Gln Cys Ser Phe Lys Val His Ala Asp Tyr Asn Ala Ala Lys Asn 
                405                 410                 415     


Ile Ser Val Tyr Asn Ile Glu Lys Val Ile Gln Lys Gln Leu Lys Leu 
            420                 425                 430         


Gln Glu Lys Leu Asn Leu Thr Lys Tyr Lys Glu Gln Tyr Ile Glu Gln 
        435                 440                 445             


Met Glu Asn Ile Asn 
    450             


<210>  340
<211>  453
<212>  PRT
<213>  Bacillus cereus

<400>  340

Met Thr Tyr Leu Ser Ile Ala Val Lys Val Met Lys Tyr Gln Ile Val 
1               5                   10                  15      


Cys Pro Val Asn Ile Glu Trp Lys Thr Phe Glu Ile Tyr Leu Arg Thr 
            20                  25                  30          


Leu Ser Tyr His Phe Arg Thr Ile Gly Asn Arg Thr Ile Gln Lys Leu 
        35                  40                  45              


Trp Glu Tyr Asp Asn Gln Ser Leu Lys His Phe Lys Asp Thr Gly Gln 
    50                  55                  60                  


Tyr Pro Ser Ala Gln Gln Leu Tyr Gly Cys Thr Gln Lys Thr Ile Ser 
65                  70                  75                  80  


Gly Tyr Ile Tyr Asp Gln Leu Lys Glu Glu Tyr Gln Asp Ile Asn Lys 
                85                  90                  95      


Ala Asn Met Ser Thr Thr Leu Gln Lys Thr Ile Lys Thr Trp Asn Ser 
            100                 105                 110         


Arg Lys Lys Glu Ile Trp Ser Gly Glu Met Ser Ile Pro Ser Phe Arg 
        115                 120                 125             


Asn Asn Leu Pro Ile Asp Ile His Gly Asn Ser Ile Gln Ile Ile Lys 
    130                 135                 140                 


Glu Lys Ser Gly Asp Tyr Ile Ala Ser Val Ser Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Phe Ile Lys Glu Asn Asp Leu Pro Asn Gly Lys Ile Leu Val Lys Leu 
                165                 170                 175     


Ser Thr Arg Lys Gln Asn Ser Met Lys Val Ile Leu Asp Arg Ile Ile 
            180                 185                 190         


Asp Ser Thr Tyr Ala Lys Gly Ala Cys Met Leu His Lys His Lys Lys 
        195                 200                 205             


Lys Trp Tyr Leu Ser Ile Thr Tyr Lys Ser Asn Ile Lys Glu Glu Leu 
    210                 215                 220                 


Lys Phe Asp Glu Asp Leu Ile Met Gly Ile Asp Met Gly Lys Ile Asn 
225                 230                 235                 240 


Val Leu Tyr Phe Ala Phe Asn Lys Gly Leu Val Arg Gly Ala Ile Ser 
                245                 250                 255     


Gly Glu Glu Ile Glu Ala Phe Arg Lys Lys Ile Glu His Arg Arg Ile 
            260                 265                 270         


Ser Leu Leu Arg Gln Gly Lys Tyr Cys Ser Gly Asn Arg Ile Gly Lys 
        275                 280                 285             


Gly Arg Lys Lys Arg Ile Lys Pro Ile Glu Val Leu Asn Asp Lys Ile 
    290                 295                 300                 


Ala Lys Phe Arg Thr Ala Thr Asn His Lys Tyr Ala Asn Tyr Ile Val 
305                 310                 315                 320 


Gln Gln Cys Leu Lys Phe Asn Cys Gly Thr Ile Gln Leu Glu Asp Leu 
                325                 330                 335     


Gln Gly Ile Ser Lys Glu Gln Thr Phe Leu Lys Asn Trp Thr Tyr Phe 
            340                 345                 350         


Asp Leu Gln Glu Lys Ile Lys Asn Gln Ala Asn Gln Tyr Gly Ile Lys 
        355                 360                 365             


Val Val Lys Ile Asp Pro Ser Tyr Thr Ser Gln Arg Cys Ser Glu Cys 
    370                 375                 380                 


Gly Cys Ile His Lys Asn Asn Arg Gln Asn Gln Ser Thr Phe Glu Cys 
385                 390                 395                 400 


Gln Gln Cys Ser Phe Lys Val His Ala Asp Tyr Asn Ala Ala Lys Asn 
                405                 410                 415     


Ile Ser Val Tyr Asn Ile Glu Lys Val Ile Gln Lys Gln Leu Lys Leu 
            420                 425                 430         


Gln Glu Lys Leu Asn Leu Thr Lys Tyr Lys Glu Gln Tyr Ile Glu Gln 
        435                 440                 445             


Met Glu Asn Ile Asn 
    450             


<210>  341
<211>  453
<212>  PRT
<213>  Bacillus thuringiensis

<400>  341

Met Thr Tyr Leu Ser Ile Ala Val Lys Val Met Lys Tyr Gln Ile Val 
1               5                   10                  15      


Cys Pro Val Asn Ile Glu Trp Lys Thr Phe Glu Ile Tyr Leu Arg Thr 
            20                  25                  30          


Leu Ser Tyr His Phe Arg Thr Ile Gly Asn Arg Thr Ile Gln Lys Leu 
        35                  40                  45              


Trp Glu Tyr Asp Asn Gln Ser Leu Lys His Phe Lys Asp Thr Gly Gln 
    50                  55                  60                  


Tyr Pro Ser Ala Gln Gln Leu Tyr Gly Cys Thr Gln Lys Thr Ile Ser 
65                  70                  75                  80  


Gly Tyr Ile Tyr Asp Gln Leu Lys Glu Glu Tyr Gln Asp Ile Asn Lys 
                85                  90                  95      


Ala Asn Met Ser Thr Thr Leu Gln Lys Thr Ile Lys Thr Trp Asn Ser 
            100                 105                 110         


Arg Lys Lys Glu Ile Trp Ser Gly Glu Met Ser Ile Pro Ser Phe Arg 
        115                 120                 125             


Asn Asn Leu Pro Ile Asp Ile His Gly Asn Ser Ile Gln Ile Ile Lys 
    130                 135                 140                 


Glu Lys Ser Gly Asp Tyr Ile Ala Ser Val Ser Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Phe Ile Lys Glu Asn Asp Leu Pro Asn Gly Lys Ile Leu Val Lys Leu 
                165                 170                 175     


Ser Thr Arg Lys Gln Asn Ser Met Lys Val Ile Leu Asp Arg Ile Ile 
            180                 185                 190         


Asp Ser Thr Tyr Ala Lys Gly Ala Cys Met Leu His Lys His Lys Lys 
        195                 200                 205             


Lys Trp Tyr Leu Ser Ile Thr Tyr Lys Ser Asn Ile Lys Glu Glu Leu 
    210                 215                 220                 


Lys Phe Asp Glu Asp Leu Ile Met Gly Ile Asp Met Gly Lys Ile Asn 
225                 230                 235                 240 


Val Leu Tyr Phe Ala Phe Asn Lys Gly Leu Val Arg Gly Ala Ile Ser 
                245                 250                 255     


Gly Glu Glu Ile Glu Ala Phe Arg Lys Lys Ile Glu His Arg Arg Ile 
            260                 265                 270         


Ser Leu Leu Arg Gln Gly Lys Tyr Cys Ser Gly Asn Arg Ile Gly Lys 
        275                 280                 285             


Gly Arg Lys Lys Arg Ile Lys Pro Ile Glu Val Leu Asn Asp Lys Ile 
    290                 295                 300                 


Ala Lys Phe Arg Thr Ala Thr Asn His Lys Tyr Ala Asn Tyr Ile Val 
305                 310                 315                 320 


Gln Gln Cys Leu Lys Tyr Asn Cys Gly Thr Ile Gln Leu Glu Asp Leu 
                325                 330                 335     


Gln Gly Ile Ser Lys Glu Gln Thr Phe Leu Lys Asn Trp Thr Tyr Phe 
            340                 345                 350         


Asp Leu Gln Glu Lys Ile Lys Asn Gln Ala Asn Gln Tyr Gly Ile Lys 
        355                 360                 365             


Val Val Lys Ile Asp Pro Ser Tyr Thr Ser Gln Arg Cys Ser Glu Cys 
    370                 375                 380                 


Gly Tyr Ile His Lys Asn Asn Arg Gln Asn Gln Ser Thr Phe Glu Cys 
385                 390                 395                 400 


Gln Gln Cys Ser Phe Lys Val His Ala Asp Tyr Asn Ala Ala Lys Asn 
                405                 410                 415     


Ile Ser Val Tyr Asn Ile Glu Lys Val Ile Gln Arg Gln Leu Lys Leu 
            420                 425                 430         


Gln Glu Lys Leu Asn Leu Thr Lys Tyr Lys Glu Gln Tyr Ile Glu Gln 
        435                 440                 445             


Met Glu Asn Ile Asn 
    450             


<210>  342
<211>  453
<212>  PRT
<213>  Bacillus sp.

<400>  342

Met Lys Tyr Leu Ser Thr Val Val Lys Val Met Lys Tyr Gln Ile Ile 
1               5                   10                  15      


Cys Pro Val Asn Ile Glu Trp Lys Ala Phe Glu Thr Tyr Leu Arg Thr 
            20                  25                  30          


Leu Ser Tyr Gln Val Arg Thr Ile Gly Asn Arg Thr Ile Gln Lys Leu 
        35                  40                  45              


Trp Asp Phe Asp Asn Gln Ser Leu Asn His Phe Arg Glu Asn Gly Val 
    50                  55                  60                  


Tyr Pro Ser Ala Gln Gln Leu Tyr Gly Cys Thr Gln Lys Thr Ile Ser 
65                  70                  75                  80  


Gly Tyr Ile Tyr Asp Gln Leu Lys Glu Glu Tyr Gln Asp Met Asn Lys 
                85                  90                  95      


Ala Asn Met Ser Thr Thr Leu Gln Lys Thr Ile Lys Thr Trp Asn Ser 
            100                 105                 110         


Arg Lys Lys Glu Ile Arg Ser Gly Glu Met Ser Ile Pro Ser Phe Arg 
        115                 120                 125             


Asn Asn Leu Pro Ile Asp Ile His Gly Asn Ser Ile Gln Ile Thr Lys 
    130                 135                 140                 


Glu Lys Ser Gly Asp Tyr Ile Ala Ser Leu Ser Leu Phe Ser Ser Asn 
145                 150                 155                 160 


Phe Ile Ile Glu Asn Asn Leu Pro Asn Gly Lys Ile Gln Val Lys Leu 
                165                 170                 175     


Ser Thr Arg Lys Gln Asn Ser Met Lys Val Ile Leu Asp Arg Ile Ile 
            180                 185                 190         


Glu Asn Thr Tyr Ala Lys Gly Ala Cys Met Leu His Lys His Lys Asn 
        195                 200                 205             


Lys Trp Tyr Leu Ser Ile Ile Tyr Lys Pro Thr Val Lys Glu Glu His 
    210                 215                 220                 


Lys Phe Glu Glu Asp Leu Val Met Gly Ile Asp Met Gly Lys Ile Asn 
225                 230                 235                 240 


Val Leu Tyr Phe Ala Phe Asn Lys Gly Trp Ile Arg Gly Ala Ile Ser 
                245                 250                 255     


Gly Glu Glu Ile Glu Ala Phe Arg Lys Lys Ile Glu His Arg Arg Ile 
            260                 265                 270         


Ser Leu Leu Arg Gln Gly Lys Tyr Cys Ser Gly Asn Arg Val Gly Lys 
        275                 280                 285             


Gly Arg Glu Lys Arg Ile Lys Pro Ile Asp Val Leu Asn Asn Lys Ile 
    290                 295                 300                 


Ala Lys Phe Arg Asn Ala Thr Asn His Lys Tyr Ala Asn Tyr Ile Val 
305                 310                 315                 320 


Gln Gln Cys Leu Lys Tyr Asn Cys Gly Thr Ile Gln Leu Glu Asn Leu 
                325                 330                 335     


Gln Gly Ile Ser Lys Glu Gln Thr Phe Leu Lys Asn Trp Thr Tyr Phe 
            340                 345                 350         


Asp Leu Gln Glu Lys Ile Lys Gln Gln Ala His Gln Tyr Gly Met Lys 
        355                 360                 365             


Val Val Thr Ile Asp Pro Ser Tyr Thr Ser Lys Arg Cys Ser Glu Cys 
    370                 375                 380                 


Gly Tyr Ile His Lys Asn Asn Arg Lys Ser Gln Ser Thr Phe Glu Cys 
385                 390                 395                 400 


Gln Gln Cys Asn Leu Lys Val His Ala Asp Tyr Asn Ala Ala Lys Asn 
                405                 410                 415     


Ile Ser Ile Tyr Asn Ile Glu Lys Val Ile Gln Lys Gln Leu Lys Leu 
            420                 425                 430         


Gln Glu Lys Leu Asn Ser Lys Lys Phe Thr Glu Gln Tyr Ile Glu Gln 
        435                 440                 445             


Val Glu Asn Ile Asn 
    450             


<210>  343
<211>  453
<212>  PRT
<213>  Prevotella copri

<400>  343

Met Ser Lys Ile Thr Arg Lys Ile Glu Ile Ile Pro Asp Val Glu Gly 
1               5                   10                  15      


Leu Thr His Glu Glu Ser Asn Glu Lys Cys Tyr Lys Ala Phe Tyr Asn 
            20                  25                  30          


Tyr Asp Arg Lys Leu Tyr Lys Val Ala Asn Leu Leu Val Ser Gln Leu 
        35                  40                  45              


Tyr Gly Leu Asp Asn Leu Leu Ser Leu Met Arg Leu Gln Asn Glu Glu 
    50                  55                  60                  


Tyr Val Asp Ser Gln Arg Lys Leu Ser Phe Lys Ser Thr Thr Asp Thr 
65                  70                  75                  80  


Ala Lys Glu Glu Ile Lys Lys Arg Met Glu Glu Ile Asp Ala Glu Leu 
                85                  90                  95      


Met Ala Ile Lys Lys Lys Ile Ala Pro Met His Pro Gln Ser Tyr Ser 
            100                 105                 110         


Tyr Arg Ala Val Asn Ser Ser Glu Tyr Ala Lys Asp Met Pro Ser Asp 
        115                 120                 125             


Ile Val Asp Ser Leu Lys Gln Asp Val Tyr Lys His Phe Asn Asp Ser 
    130                 135                 140                 


Lys Lys Glu Gln Ile Arg Gly Glu Arg Ser Leu Thr Thr Tyr Lys Arg 
145                 150                 155                 160 


Gly Met Pro Ile Pro Phe Asn Leu Lys Lys Lys His Ser Ile Val Cys 
                165                 170                 175     


Asp Gly Asp Asn Tyr Tyr Leu Pro Trp Phe Glu Asp Thr Arg Phe Arg 
            180                 185                 190         


Leu Asn Phe Gly Arg Asp Arg Ser Asn Asn Arg Ala Ile Ile Asp Asn 
        195                 200                 205             


Cys Ile Lys Thr Lys Lys Tyr Lys Leu Cys Ala Ala Ala Lys Ile Gln 
    210                 215                 220                 


Leu Lys Glu Arg Lys Leu Phe Leu Leu Ile Thr Val Asp Ile Pro Lys 
225                 230                 235                 240 


Ala Glu Ser Val Pro Val Lys Gly Lys Val Met Gly Val Asp Leu Gly 
                245                 250                 255     


Val Ile Asn Pro Ala Tyr Val Ala Val Asn Asp Gly Pro Glu Arg Ser 
            260                 265                 270         


Arg Ile Gly Asn Gly Glu Thr Phe Gln Lys Gln Arg Asp Val Phe Arg 
        275                 280                 285             


Arg Arg Phe Arg Glu Leu Gln Arg Ser Gln Leu Thr Gln Gly Gly His 
    290                 295                 300                 


Gly Arg Lys His Lys Thr Lys Ala Thr Glu Ile Leu Arg Gly Lys Glu 
305                 310                 315                 320 


Arg Asn Trp Val Gln Thr Glu Asn His Arg Ile Ser Arg Glu Ile Val 
                325                 330                 335     


Asn Leu Ala Ser Arg Trp Lys Val Glu Thr Ile Gln Met Glu Ser Leu 
            340                 345                 350         


Lys Gly Phe Gly Lys Asn Gln Glu Gly Glu Val Glu Tyr Asn His Lys 
        355                 360                 365             


Arg Leu Leu Gly Arg Trp Ser Tyr Phe Glu Leu Gln Lys Asp Ile Glu 
    370                 375                 380                 


Tyr Lys Ala Ala Met Ala Gly Ile Ala Val Gln Tyr Val Asn Pro Ala 
385                 390                 395                 400 


Tyr Thr Ser Gln Thr Cys His Val Cys Gly Gln Arg Gly Asn Arg Ile 
                405                 410                 415     


Glu Arg Asp Thr Phe Ile Cys Thr Asn Pro Glu Cys Thr Cys Tyr Asn 
            420                 425                 430         


Gln Ala Gln Asp Ala Asp Met Asn Ala Ala Ile Asn Ile Ala Lys Ser 
        435                 440                 445             


Lys Asp Val Ile Lys 
    450             


<210>  344
<211>  453
<212>  PRT
<213>  Prevotella copri

<400>  344

Met Ser Lys Ile Thr Arg Lys Ile Glu Ile Ile Pro Asp Val Glu Gly 
1               5                   10                  15      


Leu Thr His Glu Glu Ser Asn Glu Lys Cys Tyr Lys Ala Phe Tyr Asn 
            20                  25                  30          


Tyr Asp Arg Lys Leu Tyr Lys Val Ala Asn Leu Leu Val Ser Gln Leu 
        35                  40                  45              


Tyr Gly Leu Asp Asn Leu Leu Ser Leu Met Arg Leu Gln Asn Glu Glu 
    50                  55                  60                  


Tyr Val Asp Ser Gln Arg Lys Leu Ser Phe Lys Ser Thr Thr Asp Ala 
65                  70                  75                  80  


Ala Lys Glu Glu Ile Lys Lys Arg Met Glu Glu Ile Asp Ala Glu Leu 
                85                  90                  95      


Met Ala Ile Lys Lys Lys Ile Ala Pro Met His Pro Gln Ser Tyr Ser 
            100                 105                 110         


Tyr Arg Ala Val Asn Ser Ser Glu Tyr Ala Lys Asp Met Pro Ser Asp 
        115                 120                 125             


Ile Val Asp Ser Leu Lys Gln Asp Val Tyr Lys His Phe Asn Asp Ser 
    130                 135                 140                 


Lys Lys Glu Gln Ile Arg Gly Glu Arg Ser Leu Thr Thr Tyr Lys Arg 
145                 150                 155                 160 


Gly Met Pro Ile Pro Phe Asn Leu Lys Lys Lys His Ser Ile Val Cys 
                165                 170                 175     


Asp Gly Gly Asn Tyr Tyr Leu Pro Trp Phe Glu Asp Thr Arg Phe Arg 
            180                 185                 190         


Leu Asn Phe Gly Arg Asp Arg Ser Asn Asn Arg Ala Ile Ile Asp Asn 
        195                 200                 205             


Cys Ile Lys Thr Lys Lys Tyr Lys Leu Cys Ala Ala Ala Lys Ile Gln 
    210                 215                 220                 


Leu Lys Glu Arg Lys Leu Phe Leu Leu Ile Thr Val Asp Ile Pro Lys 
225                 230                 235                 240 


Ala Glu Ser Val Pro Val Lys Gly Lys Val Met Gly Val Asp Leu Gly 
                245                 250                 255     


Val Val Asn Pro Ala Tyr Val Ala Val Asn Asp Gly Pro Glu Arg Ser 
            260                 265                 270         


Arg Ile Gly Asn Gly Glu Ala Phe Gln Lys Gln Arg Asp Val Phe Arg 
        275                 280                 285             


Arg Arg Phe Arg Glu Leu Gln Arg Ser Gln Leu Thr Gln Ser Gly His 
    290                 295                 300                 


Gly Arg Lys His Lys Thr Lys Ala Thr Glu Ile Leu Arg Gly Lys Glu 
305                 310                 315                 320 


Arg Asn Trp Val Gln Thr Glu Asn His Arg Ile Ser Arg Glu Ile Val 
                325                 330                 335     


Asn Leu Ala Ser Arg Trp Lys Val Glu Thr Ile Gln Met Glu Ser Leu 
            340                 345                 350         


Lys Gly Phe Gly Lys Asn Gln Glu Gly Glu Val Glu Tyr Asn His Lys 
        355                 360                 365             


Arg Leu Leu Gly Arg Trp Ser Tyr Phe Glu Leu Gln Lys Asp Ile Glu 
    370                 375                 380                 


Tyr Lys Ala Ala Met Ala Gly Ile Ala Val Gln Tyr Val Asn Pro Ala 
385                 390                 395                 400 


Tyr Thr Ser Gln Thr Cys His Val Cys Gly Gln Arg Gly Asn Arg Ile 
                405                 410                 415     


Glu Arg Asp Thr Phe Ile Cys Thr Asn Pro Glu Cys Thr Cys Tyr Asn 
            420                 425                 430         


Gln Ala Gln Asp Ala Asp Met Asn Ala Ala Ile Asn Ile Ala Lys Ser 
        435                 440                 445             


Lys Asp Val Ile Lys 
    450             


<210>  345
<211>  461
<212>  PRT
<213>  Clostridioides difficile

<400>  345

Met Ile Ser Thr Arg Lys Ile Lys Val Arg Cys Asp Asp Ser Thr Phe 
1               5                   10                  15      


Tyr Thr Phe Phe Arg Gln Glu Gln Arg Glu Gln Asn Lys Ala Leu Asn 
            20                  25                  30          


Ile Gly Ile Gly Ile Ile His Ala Asn Ala Val Leu His Asn Val Asp 
        35                  40                  45              


Ser Gly Ala Glu Lys Lys Leu Lys Lys Ser Ile Glu Gly Leu Gln Gly 
    50                  55                  60                  


Lys Ile Asp Lys Leu Asn Lys Asp Leu Glu Lys Glu Lys Ile Thr Asp 
65                  70                  75                  80  


Lys Lys Lys Glu Glu Val Leu Lys Ala Ile Glu Thr Asn Lys Lys Ile 
                85                  90                  95      


Leu Asp Gly Glu Lys Lys Ala Phe Lys Glu Ser Glu Glu Tyr Arg Lys 
            100                 105                 110         


Gly Ile Asp Glu Leu Phe Lys Asn Thr Tyr Leu Lys Ser Asn Thr Leu 
        115                 120                 125             


Asp His Val Leu Asp Ser Met Val Asn Ile Gln Tyr Lys Arg Thr Leu 
    130                 135                 140                 


Ser Leu Val Thr Gln Arg Ile Lys Lys Asp Tyr Ser Asn Asp Phe Val 
145                 150                 155                 160 


Gly Ile Ile Thr Gly Gln Gln Ser Leu Arg Asn Tyr Arg Asn Asp Asn 
                165                 170                 175     


Pro Leu Met Ile Ser Asn Gln Gln Leu Asn Phe Lys Tyr Ile Asp Asp 
            180                 185                 190         


Thr Phe Tyr Leu Asp Ile Met Cys Gly Tyr Arg Leu Glu Val Val Leu 
        195                 200                 205             


Gly Lys Arg Asp Asn Glu Asn Val Asn Glu Leu Lys Ser Thr Leu Glu 
    210                 215                 220                 


Lys Val Ile Ser Lys Glu Tyr Lys Val Cys Asp Ser Ser Met Gln Phe 
225                 230                 235                 240 


Ser Lys Asn Asn Asn Asp Val Ile Leu Asn Leu Val Ile Asp Ile Pro 
                245                 250                 255     


Gln Asn Ser Asn Val Tyr Lys Pro Val Glu Gly Arg Thr Leu Gly Val 
            260                 265                 270         


Asp Leu Gly Val Ala Val Pro Ile Tyr Met Cys Leu Asn Asp Asp Thr 
        275                 280                 285             


Tyr Lys Arg Lys Gly Leu Gly Asp Ile Asn Asn Phe Leu Arg Val Arg 
    290                 295                 300                 


Gln Gln Met Gln Thr Arg Arg Arg Lys Leu Gln Lys Asp Leu Thr Leu 
305                 310                 315                 320 


Thr Asn Gly Gly Lys Gly Arg Lys Lys Lys Thr Gln Leu Leu Asp Lys 
                325                 330                 335     


Leu Gln Glu Asn Glu Arg Asn Phe Val Lys Thr Tyr Ser His Ala Leu 
            340                 345                 350         


Ser Lys Arg Val Val Glu Phe Ala Lys Ser Asn Lys Cys Glu Tyr Ile 
        355                 360                 365             


Asn Ile Glu Lys Leu Thr Lys Asp Gly Phe Asp Asn Ile Ile Leu Arg 
    370                 375                 380                 


Asn Trp Ser Tyr Phe Glu Leu Gln Lys Met Ile Glu Tyr Lys Ala Glu 
385                 390                 395                 400 


Arg Glu Gly Ile Thr Val Arg Tyr Val Asn Pro Ala Tyr Thr Ser Gln 
                405                 410                 415     


Lys Cys Ser Arg Cys Gly Glu Ile Asp Lys Glu Asn Arg Gln Thr Gln 
            420                 425                 430         


Ala Lys Phe Lys Cys Thr Lys Cys Gly Phe Glu Leu Asn Ala Asp His 
        435                 440                 445             


Asn Ala Ala Ile Asn Ile Ala Arg Ser Ile Glu Phe Val 
    450                 455                 460     


<210>  346
<211>  461
<212>  PRT
<213>  Clostridioides difficile

<400>  346

Met Ile Ser Thr Arg Lys Ile Lys Val Arg Cys Asp Asp Ser Thr Phe 
1               5                   10                  15      


Tyr Thr Phe Phe Arg Gln Glu Gln Arg Glu Gln Asn Lys Ala Leu Asn 
            20                  25                  30          


Ile Gly Ile Gly Ile Ile His Ala Asn Ala Val Leu His Asn Val Asp 
        35                  40                  45              


Ser Gly Ala Glu Lys Lys Leu Lys Lys Ser Ile Glu Gly Leu Gln Gly 
    50                  55                  60                  


Lys Ile Asp Lys Leu Asn Lys Asp Leu Glu Lys Glu Lys Ile Thr Asp 
65                  70                  75                  80  


Lys Lys Lys Glu Glu Val Leu Lys Ala Ile Glu Thr Asn Lys Lys Ile 
                85                  90                  95      


Leu Asp Gly Glu Lys Lys Val Phe Lys Glu Ser Glu Glu Tyr Arg Lys 
            100                 105                 110         


Gly Ile Asp Glu Leu Phe Lys Asn Thr Tyr Leu Lys Ser Asn Thr Leu 
        115                 120                 125             


Asp His Val Leu Asp Ser Met Val Asn Ile Gln Tyr Lys Arg Thr Leu 
    130                 135                 140                 


Ser Leu Val Thr Gln Arg Ile Lys Lys Asp Tyr Ser Asn Asp Phe Val 
145                 150                 155                 160 


Gly Ile Ile Thr Gly Gln Gln Ser Leu Arg Asn Tyr Arg Asn Asp Asn 
                165                 170                 175     


Pro Leu Met Ile Ser Asn Gln Gln Leu Asn Phe Lys Tyr Ile Asp Asp 
            180                 185                 190         


Thr Phe Tyr Leu Asp Ile Met Cys Gly Tyr Arg Leu Glu Val Val Leu 
        195                 200                 205             


Gly Lys Arg Asp Asn Glu Asn Val Asn Glu Leu Lys Ser Thr Leu Glu 
    210                 215                 220                 


Lys Val Ile Ser Lys Glu Tyr Lys Val Cys Asp Ser Ser Met Gln Phe 
225                 230                 235                 240 


Ser Lys Asn Asn Lys Asp Val Ile Leu Asn Leu Val Ile Asp Ile Pro 
                245                 250                 255     


Gln Asn Ser Asn Val Tyr Lys Pro Val Glu Gly Arg Ile Leu Gly Val 
            260                 265                 270         


Asp Leu Gly Val Ala Val Pro Ile Tyr Met Cys Leu Asn Asp Asp Thr 
        275                 280                 285             


Tyr Lys Arg Lys Gly Leu Gly Asp Ile Asn Asn Phe Leu Arg Val Arg 
    290                 295                 300                 


Gln Gln Met Gln Thr Arg Arg Arg Lys Leu Gln Lys Asp Leu Thr Leu 
305                 310                 315                 320 


Thr Asn Gly Gly Lys Gly Arg Lys Lys Lys Thr Gln Leu Leu Asp Lys 
                325                 330                 335     


Leu Gln Glu Asn Glu Arg Asn Phe Val Lys Thr Tyr Ser His Ala Leu 
            340                 345                 350         


Ser Lys Arg Val Val Glu Phe Ala Lys Ser Asn Lys Cys Glu Tyr Ile 
        355                 360                 365             


Asn Ile Glu Lys Leu Thr Lys Asp Gly Phe Asp Asn Ile Ile Leu Arg 
    370                 375                 380                 


Asn Trp Ser Tyr Phe Glu Leu Gln Lys Met Ile Glu Tyr Lys Ala Glu 
385                 390                 395                 400 


Arg Glu Gly Ile Thr Val Arg Tyr Val Asn Pro Ala Tyr Thr Ser Gln 
                405                 410                 415     


Lys Cys Ser Arg Cys Gly Glu Ile Asp Lys Glu Asn Arg Gln Thr Gln 
            420                 425                 430         


Ala Asn Phe Lys Cys Thr Lys Cys Gly Phe Glu Leu Asn Ala Asp His 
        435                 440                 445             


Asn Ala Ala Ile Asn Ile Ala Arg Ser Ile Glu Phe Val 
    450                 455                 460     


<210>  347
<211>  461
<212>  PRT
<213>  Clostridioides difficile

<400>  347

Met Ile Ser Thr Arg Lys Ile Lys Val Arg Cys Asp Asp Ser Thr Phe 
1               5                   10                  15      


Tyr Thr Phe Phe Arg Gln Glu Gln Arg Glu Gln Asn Lys Ala Leu Asn 
            20                  25                  30          


Ile Gly Ile Gly Ile Ile His Ala Asn Ala Val Leu His Asn Val Asp 
        35                  40                  45              


Ser Gly Ala Glu Lys Lys Leu Lys Lys Ser Ile Glu Gly Leu Gln Gly 
    50                  55                  60                  


Lys Ile Asp Lys Leu Asn Lys Asp Leu Glu Lys Glu Lys Ile Thr Asp 
65                  70                  75                  80  


Lys Lys Lys Glu Glu Val Leu Lys Ala Ile Glu Thr Asn Lys Lys Ile 
                85                  90                  95      


Leu Asp Gly Glu Lys Lys Ala Phe Lys Glu Ser Glu Glu Tyr Arg Lys 
            100                 105                 110         


Gly Ile Asp Glu Leu Phe Lys Asn Thr Tyr Leu Lys Ser Asn Thr Leu 
        115                 120                 125             


Asp His Val Leu Asp Ser Met Val Asn Ile Gln Tyr Lys Arg Thr Leu 
    130                 135                 140                 


Ser Leu Val Thr Gln Arg Ile Lys Lys Asp Tyr Ser Asn Asp Phe Val 
145                 150                 155                 160 


Gly Ile Ile Thr Gly Gln Gln Ser Leu Arg Asn Tyr Arg Asn Asp Asn 
                165                 170                 175     


Pro Leu Met Ile Ser Asn Gln Gln Leu Asn Phe Lys Tyr Ile Asp Asp 
            180                 185                 190         


Thr Phe Tyr Leu Asp Ile Met Cys Gly Tyr Arg Leu Glu Val Val Leu 
        195                 200                 205             


Gly Lys Arg Asp Asn Glu Asn Val Asn Glu Leu Lys Ser Thr Leu Glu 
    210                 215                 220                 


Lys Val Ile Ser Lys Glu Tyr Lys Val Cys Asp Ser Ser Met Gln Phe 
225                 230                 235                 240 


Ala Lys Asn Asn Lys Asp Ile Ile Leu Asn Leu Val Ile Asp Ile Pro 
                245                 250                 255     


Gln Asn Ser Asn Val Tyr Lys Pro Val Glu Gly Arg Thr Leu Gly Val 
            260                 265                 270         


Asp Leu Gly Ile Ala Val Pro Ile Tyr Met Cys Leu Asn Asp Asp Thr 
        275                 280                 285             


Tyr Lys Arg Lys Gly Leu Gly Asp Ile Asn Asn Phe Leu Arg Val Arg 
    290                 295                 300                 


Gln Gln Met Gln Thr Arg Arg Arg Lys Leu Gln Lys Asp Leu Thr Leu 
305                 310                 315                 320 


Thr Asn Gly Gly Lys Gly Arg Lys Lys Lys Thr Gln Leu Leu Asp Lys 
                325                 330                 335     


Leu Gln Glu Asn Glu Arg Asn Phe Val Lys Thr Tyr Ser His Ala Leu 
            340                 345                 350         


Ser Lys Arg Val Val Glu Phe Ala Lys Ser Asn Lys Cys Glu Tyr Ile 
        355                 360                 365             


Asn Ile Glu Lys Leu Thr Lys Asp Gly Phe Asp Asn Ile Ile Leu Arg 
    370                 375                 380                 


Asn Trp Ser Tyr Phe Glu Leu Gln Lys Met Ile Glu Tyr Lys Ala Glu 
385                 390                 395                 400 


Arg Glu Gly Ile Ala Val Arg Tyr Val Asn Pro Ala Tyr Thr Ser Gln 
                405                 410                 415     


Lys Cys Ser Arg Cys Gly Glu Ile Asp Lys Glu Asn Arg Gln Thr Gln 
            420                 425                 430         


Ala Asn Phe Lys Cys Thr Lys Cys Gly Phe Glu Leu Asn Ala Asp His 
        435                 440                 445             


Asn Ala Ala Ile Asn Ile Ala Arg Ser Ile Glu Phe Val 
    450                 455                 460     


<210>  348
<211>  461
<212>  PRT
<213>  Clostridioides difficile

<400>  348

Met Ile Ser Thr Arg Lys Ile Lys Val Arg Cys Asp Asp Ser Thr Phe 
1               5                   10                  15      


Tyr Thr Phe Phe Arg Gln Glu Gln Arg Glu Gln Asn Lys Ala Leu Asn 
            20                  25                  30          


Ile Gly Ile Gly Ile Ile His Ala Asn Ala Val Leu His Asn Val Asp 
        35                  40                  45              


Ser Gly Ala Glu Lys Lys Leu Lys Lys Ser Ile Glu Gly Leu Gln Gly 
    50                  55                  60                  


Lys Ile Asp Lys Leu Asn Lys Asp Leu Glu Lys Glu Lys Ile Thr Asp 
65                  70                  75                  80  


Lys Lys Lys Glu Glu Val Leu Lys Ala Ile Glu Thr Asn Lys Lys Ile 
                85                  90                  95      


Leu Asp Gly Glu Lys Lys Ala Phe Lys Glu Ser Glu Glu Tyr Arg Lys 
            100                 105                 110         


Gly Ile Asp Glu Leu Phe Lys Asn Thr Tyr Leu Lys Ser Asn Thr Leu 
        115                 120                 125             


Asp His Val Leu Asp Ser Met Val Asn Ile Gln Tyr Lys Arg Thr Leu 
    130                 135                 140                 


Ser Leu Val Thr Gln Arg Ile Lys Lys Asp Tyr Ser Asn Asp Phe Val 
145                 150                 155                 160 


Gly Ile Ile Thr Gly Gln Gln Ser Leu Arg Asn Tyr Arg Asn Asp Asn 
                165                 170                 175     


Pro Leu Met Ile Ser Asn Gln Gln Leu Asn Phe Lys Tyr Ile Asp Asp 
            180                 185                 190         


Thr Phe Tyr Leu Asp Ile Met Cys Gly Tyr Arg Leu Glu Val Val Leu 
        195                 200                 205             


Gly Lys Arg Asp Asn Glu Asn Val Asn Glu Leu Lys Ser Thr Leu Glu 
    210                 215                 220                 


Lys Val Ile Ser Lys Glu Tyr Lys Val Cys Asp Ser Ser Met Gln Phe 
225                 230                 235                 240 


Ala Lys Asn Asn Lys Asp Ile Ile Leu Asn Leu Val Ile Asp Ile Pro 
                245                 250                 255     


Gln Asn Ser Asn Val Tyr Lys Pro Val Glu Gly Arg Thr Leu Gly Val 
            260                 265                 270         


Asp Leu Gly Ile Ala Val Pro Ile Tyr Met Cys Leu Asn Asp Asp Thr 
        275                 280                 285             


Tyr Lys Arg Lys Gly Leu Ser Asp Ile Asn Asn Phe Leu Arg Val Arg 
    290                 295                 300                 


Gln Gln Met Gln Thr Arg Arg Arg Lys Leu Gln Lys Asp Leu Thr Leu 
305                 310                 315                 320 


Thr Asn Gly Gly Lys Gly Arg Lys Lys Lys Thr Gln Leu Leu Asp Lys 
                325                 330                 335     


Leu Gln Glu Asn Glu Arg Asn Phe Val Lys Thr Tyr Ser His Ala Leu 
            340                 345                 350         


Ser Lys Arg Val Val Glu Phe Ala Lys Ser Asn Lys Cys Glu Tyr Ile 
        355                 360                 365             


Asn Ile Glu Lys Leu Thr Lys Asp Gly Phe Asp Asn Ile Ile Leu Arg 
    370                 375                 380                 


Asn Trp Ser Tyr Phe Glu Leu Gln Lys Met Ile Glu Tyr Lys Ala Glu 
385                 390                 395                 400 


Arg Glu Gly Ile Ala Val Arg Tyr Val Asn Pro Ala Tyr Thr Ser Gln 
                405                 410                 415     


Lys Cys Ser Arg Cys Gly Glu Ile Asp Lys Glu Asn Arg Gln Thr Gln 
            420                 425                 430         


Ala Asn Phe Lys Cys Thr Lys Cys Gly Phe Glu Leu Asn Ala Asp His 
        435                 440                 445             


Asn Ala Ala Ile Asn Ile Ala Arg Ser Ile Glu Phe Val 
    450                 455                 460     


<210>  349
<211>  461
<212>  PRT
<213>  Clostridioides difficile

<400>  349

Met Ile Ser Thr Arg Lys Ile Lys Val Arg Cys Asp Asp Ser Thr Phe 
1               5                   10                  15      


Tyr Thr Phe Phe Arg Gln Glu Gln Arg Glu Gln Asn Lys Ala Leu Asn 
            20                  25                  30          


Ile Gly Ile Gly Ile Ile His Ala Asn Ala Val Leu His Asn Val Asp 
        35                  40                  45              


Ser Gly Ala Glu Lys Lys Leu Lys Lys Ser Ile Glu Gly Leu Gln Gly 
    50                  55                  60                  


Lys Ile Asp Lys Leu Asn Lys Asp Leu Glu Lys Glu Lys Ile Thr Asp 
65                  70                  75                  80  


Lys Lys Lys Glu Glu Val Leu Lys Ala Ile Glu Thr Asn Lys Lys Ile 
                85                  90                  95      


Leu Asp Gly Glu Lys Lys Ala Phe Lys Glu Ser Glu Glu Tyr Arg Lys 
            100                 105                 110         


Gly Ile Asp Glu Leu Phe Lys Asn Thr Tyr Leu Lys Ser Asn Thr Leu 
        115                 120                 125             


Asp His Val Leu Asp Ser Met Val Asn Ile Gln Tyr Lys Arg Thr Leu 
    130                 135                 140                 


Ser Leu Val Thr Gln Arg Ile Lys Lys Asp Tyr Ser Asn Asp Phe Val 
145                 150                 155                 160 


Gly Ile Ile Thr Gly Gln Gln Ser Leu Arg Asn Tyr Arg Asn Asp Asn 
                165                 170                 175     


Pro Leu Met Ile Ser Asn Gln Gln Leu Asn Phe Lys Tyr Ile Asp Asp 
            180                 185                 190         


Thr Phe Tyr Leu Asp Ile Met Cys Gly Tyr Arg Leu Glu Val Val Leu 
        195                 200                 205             


Gly Lys Arg Asp Asn Glu Asn Val Asn Glu Leu Lys Ser Thr Leu Glu 
    210                 215                 220                 


Lys Val Ile Ser Lys Glu Tyr Lys Val Cys Asp Ser Ser Met Gln Phe 
225                 230                 235                 240 


Ser Lys Asn Asn Lys Asp Val Ile Leu Asn Leu Val Ile Asp Ile Pro 
                245                 250                 255     


Gln Asn Ser Asn Val Tyr Lys Pro Val Glu Asp Arg Thr Leu Gly Val 
            260                 265                 270         


Asp Leu Gly Val Ala Val Pro Ile Tyr Met Cys Leu Asn Asp Asp Thr 
        275                 280                 285             


Tyr Lys Arg Lys Gly Leu Gly Asp Ile Asn Asn Phe Leu Arg Val Arg 
    290                 295                 300                 


Gln Gln Met Gln Thr Arg Arg Arg Lys Leu Gln Lys Asp Leu Thr Leu 
305                 310                 315                 320 


Thr Asn Gly Gly Lys Gly Arg Lys Lys Lys Thr Gln Leu Leu Asp Lys 
                325                 330                 335     


Leu Gln Glu Asn Glu Arg Asn Phe Val Lys Thr Tyr Ser His Ala Leu 
            340                 345                 350         


Ser Lys Arg Val Val Glu Phe Ala Lys Ser Asn Lys Cys Glu Tyr Ile 
        355                 360                 365             


Asn Ile Glu Lys Leu Thr Lys Asp Gly Phe Asp Asn Ile Ile Leu Arg 
    370                 375                 380                 


Asn Trp Ser Tyr Phe Glu Leu Gln Lys Met Ile Glu Tyr Lys Ala Glu 
385                 390                 395                 400 


Arg Glu Gly Ile Thr Val Arg Tyr Val Asn Pro Ala Tyr Thr Ser Gln 
                405                 410                 415     


Lys Cys Ser Arg Cys Gly Glu Ile Asp Lys Glu Asn Arg Gln Thr Gln 
            420                 425                 430         


Ala Asn Phe Lys Cys Thr Lys Cys Gly Phe Glu Leu Asn Ala Asp His 
        435                 440                 445             


Asn Ala Ala Ile Asn Ile Ala Arg Ser Ile Glu Phe Val 
    450                 455                 460     


<210>  350
<211>  461
<212>  PRT
<213>  Clostridioides difficile

<400>  350

Met Ile Ser Thr Arg Lys Ile Lys Val Arg Cys Asp Asp Ser Thr Phe 
1               5                   10                  15      


Tyr Thr Phe Phe Arg Gln Glu Gln Arg Glu Gln Asn Lys Ala Leu Asn 
            20                  25                  30          


Ile Gly Ile Gly Ile Ile His Ala Asn Ala Val Leu His Asn Val Asp 
        35                  40                  45              


Ser Gly Ala Glu Lys Lys Leu Lys Lys Ser Ile Glu Gly Leu Gln Gly 
    50                  55                  60                  


Lys Ile Asp Lys Leu Asn Lys Asp Leu Glu Lys Glu Lys Ile Thr Asp 
65                  70                  75                  80  


Lys Lys Lys Glu Glu Val Leu Lys Ala Ile Glu Thr Asn Lys Lys Ile 
                85                  90                  95      


Leu Asp Gly Glu Lys Lys Ala Phe Lys Glu Ser Glu Glu Tyr Arg Lys 
            100                 105                 110         


Gly Ile Asp Glu Leu Phe Lys Asn Thr Tyr Leu Lys Ser Asn Thr Leu 
        115                 120                 125             


Asp His Val Leu Asp Ser Met Val Asn Ile Gln Tyr Lys Arg Thr Leu 
    130                 135                 140                 


Ser Leu Val Thr Gln Arg Ile Lys Lys Asp Tyr Ser Asn Asp Phe Val 
145                 150                 155                 160 


Gly Ile Ile Thr Gly Gln Gln Ser Leu Arg Asn Tyr Arg Asn Asp Asn 
                165                 170                 175     


Pro Leu Met Ile Ser Asn Gln Gln Leu Asn Phe Lys Tyr Val Glu Asp 
            180                 185                 190         


Thr Phe Tyr Leu Asp Ile Met Cys Gly Tyr Arg Leu Glu Val Val Leu 
        195                 200                 205             


Gly Lys Arg Asp Asn Glu Asn Val Asn Glu Leu Lys Ser Thr Leu Glu 
    210                 215                 220                 


Lys Val Ile Ser Lys Glu Tyr Lys Val Cys Asp Ser Ser Met Gln Phe 
225                 230                 235                 240 


Ser Lys Asn Asn Lys Asp Val Ile Leu Asn Leu Val Ile Asp Ile Pro 
                245                 250                 255     


Gln Asn Ser Asn Val Tyr Lys Pro Val Glu Gly Arg Thr Leu Gly Val 
            260                 265                 270         


Asp Leu Gly Val Ala Val Pro Ile Tyr Met Cys Leu Asn Asp Asp Thr 
        275                 280                 285             


Tyr Lys Arg Lys Gly Leu Gly Asp Ile Asn Asn Phe Leu Arg Val Arg 
    290                 295                 300                 


Gln Gln Met Gln Thr Arg Arg Arg Lys Leu Gln Lys Asp Leu Thr Leu 
305                 310                 315                 320 


Thr Asn Gly Gly Lys Gly Arg Lys Lys Lys Thr Gln Leu Leu Asp Lys 
                325                 330                 335     


Leu Gln Glu Asn Glu Arg Asn Phe Val Lys Thr Tyr Ser His Ala Leu 
            340                 345                 350         


Ser Lys Arg Val Val Glu Phe Ala Lys Ser Asn Lys Cys Glu Tyr Ile 
        355                 360                 365             


Asn Ile Glu Lys Leu Thr Lys Asp Gly Phe Asp Asn Ile Ile Leu Arg 
    370                 375                 380                 


Asn Trp Ser Tyr Phe Glu Leu Gln Lys Met Ile Glu Tyr Lys Ala Glu 
385                 390                 395                 400 


Arg Glu Gly Ile Thr Val Arg Tyr Val Asn Pro Ala Tyr Thr Ser Gln 
                405                 410                 415     


Lys Cys Ser Arg Cys Gly Glu Ile Asp Lys Glu Asn Arg Gln Thr Gln 
            420                 425                 430         


Ala Asn Phe Lys Cys Thr Lys Cys Gly Phe Glu Leu Asn Ala Asp His 
        435                 440                 445             


Asn Ala Ala Ile Asn Ile Ala Arg Ser Ile Glu Phe Val 
    450                 455                 460     


<210>  351
<211>  461
<212>  PRT
<213>  Clostridioides difficile

<400>  351

Met Ile Ser Thr Arg Lys Ile Lys Val Arg Cys Asp Asp Ser Thr Phe 
1               5                   10                  15      


Tyr Thr Phe Phe Arg Gln Glu Gln Arg Glu Gln Asn Lys Ala Leu Asn 
            20                  25                  30          


Ile Gly Ile Gly Ile Ile His Ala Asn Ala Val Leu His Asn Val Asp 
        35                  40                  45              


Ser Gly Ala Glu Lys Lys Leu Lys Lys Ser Ile Glu Gly Leu Gln Gly 
    50                  55                  60                  


Lys Ile Asp Lys Leu Asn Lys Asp Leu Glu Lys Glu Lys Ile Thr Asp 
65                  70                  75                  80  


Lys Lys Lys Glu Glu Val Leu Lys Ala Ile Glu Thr Asn Lys Lys Ile 
                85                  90                  95      


Leu Asp Gly Glu Lys Lys Ala Phe Lys Glu Ser Glu Glu Tyr Arg Lys 
            100                 105                 110         


Gly Ile Asp Glu Leu Phe Lys Asn Thr Tyr Leu Lys Ser Asn Thr Leu 
        115                 120                 125             


Asp His Val Leu Asp Ser Met Val Asn Ile Gln Tyr Lys Arg Thr Leu 
    130                 135                 140                 


Ser Leu Val Thr Gln Arg Ile Lys Lys Asp Tyr Ser Asn Asp Phe Val 
145                 150                 155                 160 


Gly Ile Ile Thr Gly Gln Gln Ser Leu Arg Asn Tyr Arg Asn Asp Asn 
                165                 170                 175     


Pro Leu Met Ile Ser Asn Gln Gln Leu Asn Phe Lys Tyr Ile Asp Asp 
            180                 185                 190         


Thr Phe Tyr Leu Asp Ile Met Cys Gly Tyr Arg Leu Glu Val Val Leu 
        195                 200                 205             


Gly Lys Arg Asp Asn Glu Asn Val Asn Glu Leu Lys Ser Thr Leu Glu 
    210                 215                 220                 


Lys Val Ile Ser Lys Glu Tyr Lys Val Cys Asp Ser Ser Met Gln Phe 
225                 230                 235                 240 


Ser Lys Asn Asn Lys Asp Val Ile Leu Asn Leu Val Ile Asp Ile Pro 
                245                 250                 255     


Gln Asn Ser Ser Val Tyr Lys Pro Val Glu Gly Arg Thr Leu Gly Val 
            260                 265                 270         


Asp Leu Gly Val Ala Val Pro Ile Tyr Met Cys Leu Asn Asp Asp Thr 
        275                 280                 285             


Tyr Lys Arg Lys Gly Leu Gly Asp Ile Asn Asn Phe Leu Arg Val Arg 
    290                 295                 300                 


Gln Gln Met Gln Thr Arg Arg Arg Lys Leu Gln Lys Asp Leu Thr Leu 
305                 310                 315                 320 


Thr Asn Gly Gly Lys Gly Arg Lys Lys Lys Thr Gln Leu Leu Asp Lys 
                325                 330                 335     


Leu Gln Glu Asn Glu Arg Asn Phe Val Lys Thr Tyr Ser His Ala Leu 
            340                 345                 350         


Ser Lys Arg Val Val Glu Phe Ala Lys Ser Asn Lys Cys Glu Tyr Ile 
        355                 360                 365             


Asn Ile Glu Lys Leu Thr Lys Asp Gly Phe Asp Asn Ile Ile Leu Arg 
    370                 375                 380                 


Asn Trp Ser Tyr Phe Glu Leu Gln Lys Met Ile Glu Tyr Lys Ala Glu 
385                 390                 395                 400 


Arg Glu Gly Ile Thr Val Arg Tyr Val Asn Pro Ala Tyr Thr Ser Gln 
                405                 410                 415     


Lys Cys Ser Arg Cys Gly Glu Ile Asp Lys Glu Asn Arg Gln Thr Gln 
            420                 425                 430         


Ala Asn Phe Lys Cys Thr Lys Cys Gly Phe Glu Leu Asn Ala Asp His 
        435                 440                 445             


Asn Ala Ala Ile Asn Ile Ala Arg Ser Ile Glu Phe Val 
    450                 455                 460     


<210>  352
<211>  463
<212>  PRT
<213>  Flavobacterium thermophilum

<400>  352

Met Thr Cys Thr Lys Thr Met Arg Tyr Gln Ile Val Arg Pro Leu Asp 
1               5                   10                  15      


Asp Asp Trp Glu Val Phe Arg Tyr Ile Leu Asn Gln Ile Ser Tyr Glu 
            20                  25                  30          


Thr Trp Asn Cys Leu Asn Arg Cys Ala Gln Tyr Leu Trp Glu Ala Asp 
        35                  40                  45              


Asn Phe Lys Lys Ile Tyr Tyr Ser Lys Phe Gly Ile Lys Phe Asn Val 
    50                  55                  60                  


Lys Asp Val Glu Gly Val Ala Asp Asp Ala Tyr Ile Asn Arg Asn Leu 
65                  70                  75                  80  


Lys Lys Glu Phe Gln Lys Met Asn Gly Asp Ser Val Glu Thr Ile Thr 
                85                  90                  95      


Arg Glu Val Lys Val Lys Met Lys Lys Asn Lys Glu Asp Phe Met Leu 
            100                 105                 110         


Gly Lys Ala Ser Phe Leu Ser Phe Lys Lys Gly His Pro Ile Leu Phe 
        115                 120                 125             


Arg Gly Ser Gln Val Lys Ile Asn Lys Ser Asn Asp Asn Asn Tyr Ile 
    130                 135                 140                 


Val Thr Val Arg Leu Leu Arg Lys Glu Tyr Ala Glu Glu Leu Tyr Asn 
145                 150                 155                 160 


Gly Ile Thr Val Lys Thr Lys Asn Lys Lys Glu Glu Lys Val His Lys 
                165                 170                 175     


Arg Asn Ile Asn Asp Met Asn Ile Arg Phe Tyr Ile Lys Ala Asn Asp 
            180                 185                 190         


Lys Tyr Asn Lys Val Ile Leu Glu Arg Val Leu Asn Lys Glu Tyr Lys 
        195                 200                 205             


Ile Gly Gly Ser Arg Ile Phe Met Lys Gly Asn Lys Ile Phe Phe Asp 
    210                 215                 220                 


Leu Val Tyr Ser Phe Glu Gln Lys Lys Asp Glu Lys Leu Asp Lys Asn 
225                 230                 235                 240 


Arg Ile Met Gly Ile Asp Ile Gly Tyr Asn Ile Pro Ala Ala Val Ala 
                245                 250                 255     


Ile Asn Asp Met Pro Tyr Lys Lys Trp Phe Ile Gly Asp Arg Lys Glu 
            260                 265                 270         


Ile Glu Asp Phe Arg Thr Lys Ile Glu Val Arg Lys Lys Gln Leu Gln 
        275                 280                 285             


Lys Trp Ser Val Trp Ala Gly Asp Gly Arg Val Gly His Gly Ile Lys 
    290                 295                 300                 


Thr Arg Ile Lys Pro Val Leu Asn Ile Gly Glu Lys Ile Asn Asn Phe 
305                 310                 315                 320 


Lys Asn Leu Lys Asn His Val Trp Ser Arg Glu Ile Ile Asn Ile Ala 
                325                 330                 335     


Leu Lys Asn Lys Cys Gly Thr Ile Gln Met Glu Lys Leu Glu Gly Ile 
            340                 345                 350         


Ile Pro Glu Glu Tyr Ser Phe Leu Lys Asn Trp Ser Phe Tyr Asp Leu 
        355                 360                 365             


Gln Gln Lys Ile Glu Tyr Lys Ala Arg Glu His Gly Ile Asp Val Val 
    370                 375                 380                 


Tyr Ile Asp Pro Ala Tyr Thr Ser Ala Arg Cys Ser Lys Cys Gly His 
385                 390                 395                 400 


Ile His Lys Ser Tyr Glu Lys Lys Asp Trp Arg Pro Glu Gln Gly Gln 
                405                 410                 415     


Phe Ile Cys Gln Val Cys Gly Tyr Lys Glu Asn Ala Asp Ile Asn Ala 
            420                 425                 430         


Ala Arg Asn Ile Ala Thr Pro Asn Ile Glu Lys Ile Ile Lys Glu Gln 
        435                 440                 445             


Leu Glu Lys Gln Glu Arg Glu Gln Arg Asn Gln Lys Tyr Ile Ser 
    450                 455                 460             


<210>  353
<211>  464
<212>  PRT
<213>  Phascolarctobacterium sp.

<400>  353

Met Ser Ile Lys Ala Ile Arg Leu Glu Ile Leu Lys Pro Tyr Asn Glu 
1               5                   10                  15      


Pro Asp Thr Ala Thr Pro Val Thr Trp Asn Glu Leu Gly Gln Val Leu 
            20                  25                  30          


Arg Asp Val Arg Tyr Ala Cys Ser Lys Thr Glu Asn Tyr Ala Ile Thr 
        35                  40                  45              


Lys Cys Tyr Leu Trp Glu Gln Phe Lys Ile Glu Tyr Lys Asn Asn Asn 
    50                  55                  60                  


Gly Ile Phe Pro Asn Ala Lys Asp Phe Lys Glu Met Thr Asp Leu Tyr 
65                  70                  75                  80  


Ser Gln Leu Thr Ala Met Phe Pro Asp Val Ala Ala Ala Ile Val Asn 
                85                  90                  95      


Gln Ala Asp Gln Val Ala Thr Arg Lys Trp Asn Asn Glu Lys Lys Asp 
            100                 105                 110         


Val Leu Ser Leu Arg Arg Ser Leu Thr Ser Phe Lys Leu Asp Val Pro 
        115                 120                 125             


Ile Pro Ile His Asn Lys Ser Tyr Lys Leu Arg Lys Ile Ser Glu Asp 
    130                 135                 140                 


Asn Lys Ile Ile Tyr Val Ile Asn Val Asn Leu Leu Ser Lys Lys Ser 
145                 150                 155                 160 


Glu Arg Gln Thr Thr Tyr Ser Met Val Leu Lys Val Lys Asp Asn Ser 
                165                 170                 175     


Ser Lys Thr Ile Leu Asp Arg Leu Ile Asn Lys Glu Leu Ser Pro Lys 
            180                 185                 190         


Gly Ile Gln Ile Ile Gly Ser Asn Lys Asn Arg Gln Lys Trp Phe Cys 
        195                 200                 205             


Leu Ile Pro Tyr Asp Phe Thr Glu Lys Asp Thr Glu Leu Asn Pro Asp 
    210                 215                 220                 


Arg Ile Met Gly Ile Asp Leu Gly Ile Ala Lys Ala Val Tyr Tyr Ala 
225                 230                 235                 240 


Phe Ser Asp Ser Tyr Lys Arg Gly Tyr Ile Glu Gly Gly Glu Ile Glu 
                245                 250                 255     


His Phe Arg Lys Ser Val Arg Ala Arg Arg Ile Ala Ile Gln Asn Gln 
            260                 265                 270         


Gly Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Val Lys Arg Arg 
        275                 280                 285             


Leu Gln Pro Val Glu Ala Leu Arg Glu Lys Glu Lys Asn Phe Arg Asn 
    290                 295                 300                 


Leu Thr Asn His Arg Tyr Ala Arg Arg Leu Val Glu Val Ala Val Lys 
305                 310                 315                 320 


Asn His Cys Gly Val Ile Gln Met Glu Asp Leu Thr Ser Ile Thr Lys 
                325                 330                 335     


Asp Asn Thr Phe Leu Lys Asp Trp Pro Tyr Tyr Asp Leu Gln Thr Lys 
            340                 345                 350         


Ile Ala Glu Lys Ala Ser Glu Tyr Gly Ile Val Phe Lys Lys Ile Asn 
        355                 360                 365             


Pro Tyr Lys Thr Ser Gln Arg Cys Ser Arg Cys Gly Tyr Ile Asp Ser 
    370                 375                 380                 


Glu Asn Arg Pro Glu Gln Ser Val Phe Val Cys Arg Glu Cys Gly Tyr 
385                 390                 395                 400 


Gly Asn Met Tyr Leu Cys Glu Asp Cys Asn Lys Glu Gln Asn His Ala 
                405                 410                 415     


Gly Lys Cys Asp Ser Cys Gly Gly Val Thr Asn Leu Ile Thr Val Asn 
            420                 425                 430         


Ala Asp Tyr Asn Ala Ala Lys Asn Ile Ala Thr Lys Asp Ile Glu Gln 
        435                 440                 445             


Ile Ile Lys Lys Thr Met Gly Lys Asp Tyr Asn Pro Pro Lys Lys Lys 
    450                 455                 460                 


<210>  354
<211>  471
<212>  PRT
<213>  Bacillus pseudomycoides

<400>  354

Met Ile Ile Ala Arg Lys Ile Lys Leu Ile Ile Ile Gly Glu Asp Arg 
1               5                   10                  15      


Asp Thr Gln Tyr Lys Phe Ile Arg Glu Glu Arg Tyr Lys Gln Asn Lys 
            20                  25                  30          


Ala Leu Asn Val Ala Met Asn His Leu Tyr Phe Leu His Val Ala Lys 
        35                  40                  45              


Glu Lys Ile Arg Leu Leu Asp Asn Lys Phe Leu Gln Asp Glu Lys Lys 
    50                  55                  60                  


Leu Gln Glu Gly Ile Lys Lys Leu Tyr Ala Glu Lys Lys Val Ile Lys 
65                  70                  75                  80  


Asp Gly Lys Lys Arg Asn Glu Leu Glu Lys Lys Ile Glu Lys Gln Thr 
                85                  90                  95      


Asn Glu Leu Lys Lys Leu Arg Ser Lys Gly Asn Lys Glu Ala Asp Lys 
            100                 105                 110         


Ile Leu Gln Glu Ala Ile Lys Ile Asn Leu Ser Ser Thr Thr Arg Glu 
        115                 120                 125             


Val Ile Ser Lys Gln Phe Asp Leu Ile Ser Asp Thr Lys Asp Arg Ile 
    130                 135                 140                 


Thr Gln Lys Val Tyr Gln Asp Phe Lys Ser Asp Leu Lys Asn Gly Leu 
145                 150                 155                 160 


Leu Ser Gly Glu Arg Val Leu Arg Thr Tyr Lys Lys Asn Asn Pro Leu 
                165                 170                 175     


Leu Ile Arg Gly Arg Ala Leu Asn Phe Tyr Arg Glu Gly Lys Asp Val 
            180                 185                 190         


Met Ile Lys Trp Phe Gly Gly Ile Ile Phe Lys Cys Met Leu Gly Gln 
        195                 200                 205             


His Lys Asn Asn Ala Gln Glu Leu Lys Ala Thr Leu Asn Lys Val Leu 
    210                 215                 220                 


Glu Gly Ser Tyr Lys Val Cys Asp Ser Ser Ile Ser Val Gly Lys Glu 
225                 230                 235                 240 


Leu Ile Leu Asn Ile Ser Leu Asp Ile Gly Glu Val Asn Ser Asn Val 
                245                 250                 255     


Ser Cys Lys Lys Gly Arg Val Leu Gly Val Asp Leu Gly Met Lys Val 
            260                 265                 270         


Pro Ala Tyr Met Ser Ile Asn Asp Lys Pro Tyr Ile Arg Lys Ser Leu 
        275                 280                 285             


Gly Ser Leu Asp Asp Phe Leu Arg Ile Arg Val Gln Met Gln Lys Arg 
    290                 295                 300                 


Arg Arg Asn Leu His Lys Thr Leu Val Ser Val Lys Gly Gly Lys Gly 
305                 310                 315                 320 


Arg Glu Lys Lys Leu Gln Ala Leu Asp Arg Leu Lys Glu Lys Asn Phe 
                325                 330                 335     


Ala Thr Thr Tyr Asn His Phe Leu Ser Tyr Asn Ile Val Lys Phe Ala 
            340                 345                 350         


Lys Asp Asn Leu Ala Glu Gln Ile Asn Met Glu Phe Leu Ala Leu Ala 
        355                 360                 365             


Gly Glu Asp Lys Asn Ile Ile Leu Arg Asn Trp Ser Tyr Tyr Gln Leu 
    370                 375                 380                 


Gln Gln Phe Val Glu Asp Lys Ala Lys Arg Glu Gly Ile Asp Val Lys 
385                 390                 395                 400 


Tyr Val Asp Pro Tyr Arg Thr Ser Gln Met Cys Ser Lys Cys Arg Asn 
                405                 410                 415     


Tyr Glu Pro Gly Gln Arg Glu Ser Gln Glu Lys Phe Ile Cys Lys Ser 
            420                 425                 430         


Cys His Leu Glu Ile Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ala 
        435                 440                 445             


His Ser Thr Lys Tyr Ile Thr Asn Lys Asn Gln Ser Glu Tyr Phe Lys 
    450                 455                 460                 


Lys Leu Gln His Thr Thr Glu 
465                 470     


<210>  355
<211>  471
<212>  PRT
<213>  Bacteroides plebeius

<400>  355

Met Pro Ile Ile Thr Arg Lys Ile Glu Leu Lys Ile Val Lys Asp Gly 
1               5                   10                  15      


Leu Thr Asp Glu Glu Tyr Asp Gln Gln Trp Lys Tyr Leu Tyr Gln Ile 
            20                  25                  30          


Asn Asn Thr Ile Tyr Leu Ala Ala Asn Arg Ile Ser Thr His Cys Leu 
        35                  40                  45              


Phe Asn Asp Glu Tyr Glu Met Arg Leu Lys Leu His Met Pro Arg Tyr 
    50                  55                  60                  


Lys Glu Ile Glu Lys Glu Leu Lys Lys Leu Asp Ser Asp Lys Lys Thr 
65                  70                  75                  80  


Ser Asp Lys Glu Ile Arg Asp Arg Leu Leu Asn Glu Arg Lys Glu Leu 
                85                  90                  95      


Asp Glu Asp Val Lys Asn Lys Lys Lys Asp Phe Leu Gln Cys Ser Lys 
            100                 105                 110         


Gln Asn Ser Thr Tyr Gln Leu Val Ser Lys Glu Phe Lys Gln Tyr Ile 
        115                 120                 125             


Pro Ser Asp Ile Leu Ala Asn Leu Asn Gln Lys Ile Gln Glu Asn Tyr 
    130                 135                 140                 


Asn Asn Asn Gln Lys Lys Ile Glu Ser Gly Glu Arg Ala Leu Ser Thr 
145                 150                 155                 160 


Tyr Lys Lys Gly Met Glu Ile Pro Phe Ser Ile Arg Glu Asn Lys Arg 
                165                 170                 175     


Leu Lys Leu Phe Ile Lys Glu Glu Gly Ile Tyr Leu Lys Trp Phe Lys 
            180                 185                 190         


Glu Ile Leu Phe Arg Leu Glu Phe Gly Lys Asp Ala Ser Asn Asn Arg 
        195                 200                 205             


Cys Ile Val Glu Arg Leu Ile Glu Ser Asp Arg Gln Gln Lys Asn Lys 
    210                 215                 220                 


Gly Glu Asp Tyr Val Ala Asn Asn Ser Ser Ile Lys Leu Val Lys Tyr 
225                 230                 235                 240 


Gly Lys Ser Thr Arg Ile Phe Leu Leu Leu Ser Ile Asp Ile Pro Ala 
                245                 250                 255     


Lys Lys Gln Val Leu Asp Lys Asp Val Val Leu Gly Val Asp Leu Gly 
            260                 265                 270         


Ile Lys Cys Pro Leu Tyr Leu Ala Ile Asn Lys Asn Asp Asn Phe Lys 
        275                 280                 285             


Met Gln Ile Gly Asp Ile Glu His Phe His Asn Gln Arg Thr Met Phe 
    290                 295                 300                 


Gln Lys Arg Phe Lys Ser Leu Gln Lys Leu Met Cys Thr Gln Gly Gly 
305                 310                 315                 320 


His Gly Arg Lys Lys Lys Leu Glu Pro Leu Glu Lys Leu Lys Glu Lys 
                325                 330                 335     


Glu Arg Asn Trp Val His Thr Gln Asn His Val Tyr Ser Arg Glu Val 
            340                 345                 350         


Ile Lys Gln Ala Leu Lys Gln Asn Ala Gly Thr Ile His Met Glu Ser 
        355                 360                 365             


Leu Lys Asp Phe Gly Lys Gly Lys Asp Gly Tyr Val Lys Asp Glu Tyr 
    370                 375                 380                 


Lys Tyr Leu Leu Arg Tyr Trp Ser Tyr Tyr Glu Leu Gln Ser Met Ile 
385                 390                 395                 400 


Glu Tyr Lys Ala Lys Leu Glu Gly Ile Glu Val Lys Tyr Ile Asp Pro 
                405                 410                 415     


Ala Tyr Thr Ser Gln Thr Cys Ser Tyr Cys Gly Glu Arg Gly Glu Arg 
            420                 425                 430         


Lys Lys Gln Glu Glu Phe Val Cys Thr Asn Pro Gln Cys Lys Arg Arg 
        435                 440                 445             


Gly Glu Lys Ile Asn Ala Asp Phe Asn Ala Ala Arg Asn Ile Ala Met 
    450                 455                 460                 


Ser Lys Lys Ile Val Glu Arg 
465                 470     


<210>  356
<211>  477
<212>  PRT
<213>  Clostridium botulinum

<400>  356

Met Pro Phe Ile Leu Lys Gln Arg Gly Val Arg Met Ile Thr Val Arg 
1               5                   10                  15      


Lys Leu Lys Ile Val Cys Lys Asp Lys Glu Phe Tyr Asp Phe Phe Lys 
            20                  25                  30          


Trp Glu Gln Arg Glu Gln Asn Lys Ala Leu Asn Ile Ala Ile Gly Leu 
        35                  40                  45              


Ile His Ser Ser Thr Val Leu Arg Ser Ile Asp Ser Gly Ala Glu Ala 
    50                  55                  60                  


Gln Leu Lys Lys Ser Ile Gly Lys Leu Thr Gln Asn Ile Glu Lys Leu 
65                  70                  75                  80  


Gly Lys Glu Leu Glu Lys Glu Lys Ile Thr Asp Lys Lys Lys Glu Gln 
                85                  90                  95      


Leu Leu Lys Ala Ile Asn Thr Asn Lys Glu Leu Ile Ala Ser Lys Glu 
            100                 105                 110         


Lys Glu Leu Lys Ala Gly Glu Glu Phe Arg Cys Gly Ile Asp Lys Lys 
        115                 120                 125             


Phe Asn Glu Leu Tyr Met Asn Lys Thr Thr Leu Tyr His Val Leu Asp 
    130                 135                 140                 


Ser Ile Cys Asp Phe Lys Tyr Lys Arg Thr Ile Glu Leu Val Arg Gln 
145                 150                 155                 160 


Lys Val Lys Gln Asp Tyr Ser Asn Ser Phe Thr Asp Ile Val Thr Gly 
                165                 170                 175     


Lys Val Ser Leu Gln Asn Tyr Lys Ser Thr Phe Pro Leu Met Ile Asp 
            180                 185                 190         


Gly Ser Cys Ile Ser Ile Leu Lys Glu Val Asp Glu Leu Asp Ile Val 
        195                 200                 205             


Asn Gly Tyr Lys Ile Lys Ile Met Leu Gly Tyr Glu Leu Asp Ile Ile 
    210                 215                 220                 


Leu Gly Lys Arg Glu Asn Glu Asn Ser Leu Glu Leu Gln Lys Thr Leu 
225                 230                 235                 240 


Glu Lys Cys Ile Thr Gly Asp Tyr Lys Ile Cys Ala Ser Ser Ile Gln 
                245                 250                 255     


Arg Asp Lys Asn Asn Asn Val Ile Phe Asn Leu Thr Leu Asp Ile Pro 
            260                 265                 270         


Ile Glu Lys Asp Tyr Lys Pro Val Lys Gly Arg Val Cys Gly Val Asp 
        275                 280                 285             


Leu Gly Ile Lys Tyr Pro Ala Tyr Met Cys Leu Asn Glu Asp Thr Tyr 
    290                 295                 300                 


Lys Lys Glu Ala Val Gly Ser Ile Asn Asn Phe Leu Arg Ile Arg Lys 
305                 310                 315                 320 


Gln Met Gln Glu Arg Arg Lys Lys Leu Gln Lys Glu Leu Leu Leu Thr 
                325                 330                 335     


Asn Gly Gly Lys Gly Arg Thr Lys Lys Thr Gln Ala Leu Glu Lys Leu 
            340                 345                 350         


Arg Glu Asn Glu Lys Asn Phe Ala Lys Thr Tyr Asn His Ala Ile Ser 
        355                 360                 365             


Lys Arg Ile Val Gly Phe Ala Arg Lys Asn Lys Cys Glu Tyr Ile Asn 
    370                 375                 380                 


Leu Glu Lys Leu Thr Lys Asp Gly Phe Gly Asp Ser Ile Leu Arg Asn 
385                 390                 395                 400 


Trp Ser Tyr Phe Glu Leu Gln Lys Met Ile Glu Tyr Lys Ala Lys Ser 
                405                 410                 415     


Lys Gly Ile Glu Val Arg Tyr Ile Asp Pro Cys Phe Thr Ser Gln Lys 
            420                 425                 430         


Cys Ser Lys Cys Gly Tyr Ile Asp Lys Glu Asn Arg Glu Thr Gln Glu 
        435                 440                 445             


Asp Phe Ile Cys Lys Lys Cys Gly Phe Lys Leu Asn Ala Asp His Asn 
    450                 455                 460                 


Ala Ser Ile Asn Ile Ala Arg Ser Lys Glu Phe Ile Lys 
465                 470                 475         


<210>  357
<211>  478
<212>  PRT
<213>  Bacillus pseudomycoides

<400>  357

Met Ile Ile Ala Arg Lys Ile Lys Leu Ile Ile Ile Gly Glu Asn Arg 
1               5                   10                  15      


Asp Ala Gln Tyr Lys Phe Ile Arg Glu Glu Arg Tyr Lys Gln Asn Lys 
            20                  25                  30          


Ala Leu Asn Val Ala Met Asn His Leu Tyr Phe Leu His Val Ala Lys 
        35                  40                  45              


Glu Lys Ile Arg Leu Leu Asp Asn Lys Phe Leu Gln Asp Glu Lys Lys 
    50                  55                  60                  


Leu Gln Glu Ser Ile Asn Lys Leu Tyr Ala Glu Lys Lys Val Ile Lys 
65                  70                  75                  80  


Asp Glu Lys Lys Arg Asn Glu Leu Glu Lys Lys Ile Glu Lys Gln Thr 
                85                  90                  95      


Asn Glu Leu Lys Lys Leu Arg Ser Lys Ser Asn Lys Glu Ala Asp Lys 
            100                 105                 110         


Val Leu Gln Glu Ala Ile Lys Ile Asn Leu Ser Ser Thr Thr Arg Glu 
        115                 120                 125             


Val Ile Ser Lys Gln Phe Glu Leu Ile Ser Asp Thr Lys Asp Arg Ile 
    130                 135                 140                 


Thr Gln Lys Val Ser Gln Asp Phe Lys Ser Asp Leu Lys His Gly Leu 
145                 150                 155                 160 


Leu Ser Gly Glu Arg Val Leu Arg Thr Tyr Lys Lys Asn Asn Pro Leu 
                165                 170                 175     


Leu Ile Arg Gly Arg Ala Leu Asn Phe Tyr Arg Glu Gly Lys Asp Val 
            180                 185                 190         


Met Ile Lys Trp Tyr Gly Gly Ile Ile Phe Lys Cys Met Leu Gly Gln 
        195                 200                 205             


His Lys Asn Asn Ala Pro Glu Leu Lys Ala Thr Leu Ser Lys Val Leu 
    210                 215                 220                 


Glu Gly Ser Tyr Lys Val Cys Asp Ser Ser Ile Ser Val Gly Lys Glu 
225                 230                 235                 240 


Leu Ile Leu Asn Leu Ser Leu Asp Ile Gly Glu Val Asp Thr Asn Val 
                245                 250                 255     


Ser Cys Lys Lys Gly Arg Val Leu Gly Val Asp Leu Gly Met Lys Val 
            260                 265                 270         


Pro Ala Tyr Met Ser Ile Asn Asp Lys Pro Tyr Ile Arg Lys Ala Leu 
        275                 280                 285             


Gly Ser Leu Asp Asp Phe Leu Lys Ile Arg Val Gln Met Gln Lys Arg 
    290                 295                 300                 


Arg Arg Asn Leu His Lys Thr Leu Val Asn Val Lys Gly Gly Lys Gly 
305                 310                 315                 320 


Arg Glu Lys Lys Leu Gln Ala Leu Asp Arg Leu Lys Asp Lys Glu Lys 
                325                 330                 335     


Asn Phe Ala Thr Thr Tyr Asn His Phe Leu Ser Tyr Asn Ile Val Lys 
            340                 345                 350         


Phe Ala Lys Asp Asn Leu Ala Glu Gln Ile Asn Met Glu Phe Leu Ala 
        355                 360                 365             


Leu Ala Gly Glu Asp Lys Asn Ile Ile Leu Arg Asn Trp Ser Tyr Tyr 
    370                 375                 380                 


Gln Leu Gln Gln Phe Val Glu Tyr Lys Ala Lys Arg Glu Gly Ile Asp 
385                 390                 395                 400 


Val Lys Tyr Val Asp Pro Tyr Arg Thr Ser Gln Met Cys Ser Lys Cys 
                405                 410                 415     


Gly Asn Tyr Glu Pro Gly Gln Arg Glu Ser Gln Glu Lys Phe Ile Cys 
            420                 425                 430         


Lys Ser Cys His Leu Glu Ile Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
        435                 440                 445             


Ile Ala His Ser Thr Lys Tyr Ile Thr Asn Lys Asn Gln Ser Glu Tyr 
    450                 455                 460                 


Leu Lys Lys Leu Gln Gln Thr Thr Lys Leu Glu Lys Tyr Ser 
465                 470                 475             


<210>  358
<211>  478
<212>  PRT
<213>  Bacillus pseudomycoides

<400>  358

Met Ile Ile Ala Arg Lys Ile Lys Leu Ile Ile Ile Gly Glu Asn Arg 
1               5                   10                  15      


Asp Thr Gln Tyr Lys Phe Ile Arg Glu Glu Arg Tyr Lys Gln Asn Lys 
            20                  25                  30          


Ala Leu Asn Val Ala Met Asn His Leu Tyr Phe Leu His Val Ala Lys 
        35                  40                  45              


Glu Lys Ile Arg Leu Leu Asp Asn Lys Phe Leu Gln Asp Glu Lys Lys 
    50                  55                  60                  


Leu Gln Glu Ser Ile Asn Lys Leu Tyr Ala Glu Lys Lys Val Ile Lys 
65                  70                  75                  80  


Asp Glu Lys Lys Arg Asn Glu Leu Glu Lys Lys Ile Glu Lys Gln Thr 
                85                  90                  95      


Asn Glu Leu Lys Lys Leu Arg Ser Lys Gly Asn Lys Glu Ala Asp Lys 
            100                 105                 110         


Val Leu Gln Glu Ala Ile Lys Ile Asn Leu Ser Ser Thr Thr Arg Glu 
        115                 120                 125             


Val Ile Ser Lys Gln Phe Glu Leu Ile Ser Asp Thr Lys Asp Arg Ile 
    130                 135                 140                 


Thr Gln Lys Val Ser Gln Asp Phe Lys Ser Asp Leu Lys His Gly Leu 
145                 150                 155                 160 


Leu Ser Gly Glu Arg Val Leu Arg Thr Tyr Lys Lys Asn Asn Pro Leu 
                165                 170                 175     


Leu Ile Arg Gly Arg Ala Leu Asn Phe Tyr Arg Glu Gly Lys Asp Val 
            180                 185                 190         


Met Ile Lys Trp Tyr Gly Gly Ile Ile Phe Lys Cys Met Leu Gly Gln 
        195                 200                 205             


His Lys Asn Asn Ala Pro Glu Leu Lys Ala Thr Leu Ser Lys Val Leu 
    210                 215                 220                 


Glu Gly Ser Tyr Lys Val Cys Asp Ser Ser Ile Ser Val Gly Lys Glu 
225                 230                 235                 240 


Leu Ile Leu Asn Leu Ser Leu Asp Ile Gly Glu Val Asp Thr Asn Val 
                245                 250                 255     


Ser Cys Lys Lys Gly Arg Val Leu Gly Val Asp Leu Gly Met Lys Val 
            260                 265                 270         


Pro Ala Tyr Met Ser Ile Asn Asp Lys Pro Tyr Ile Arg Lys Ala Leu 
        275                 280                 285             


Gly Ser Leu Asp Asp Phe Leu Lys Ile Arg Val Gln Met Gln Lys Arg 
    290                 295                 300                 


Arg Arg Asn Leu His Lys Thr Leu Val Asn Val Lys Gly Gly Lys Gly 
305                 310                 315                 320 


Arg Glu Lys Lys Leu Gln Ala Leu Asp Arg Leu Lys Asp Lys Glu Lys 
                325                 330                 335     


Asn Phe Ala Thr Thr Tyr Asn His Phe Leu Ser Tyr Asn Ile Val Lys 
            340                 345                 350         


Phe Ala Lys Asp Asn Leu Ala Glu Gln Ile Asn Met Glu Phe Leu Ala 
        355                 360                 365             


Leu Ala Gly Glu Asp Lys Asn Ile Ile Leu Arg Asn Trp Ser Tyr Tyr 
    370                 375                 380                 


Gln Leu Gln Gln Phe Val Glu Tyr Lys Ala Lys Arg Glu Gly Ile Asp 
385                 390                 395                 400 


Val Lys Tyr Val Asp Pro Tyr Arg Thr Ser Gln Met Cys Ser Lys Cys 
                405                 410                 415     


Gly Asn Tyr Glu Pro Gly Gln Arg Glu Ser Gln Glu Lys Phe Ile Cys 
            420                 425                 430         


Lys Ser Cys His Leu Glu Ile Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
        435                 440                 445             


Ile Ala His Ser Thr Lys Tyr Ile Thr Asn Lys Asn Gln Ser Glu Tyr 
    450                 455                 460                 


Leu Lys Lys Leu Gln Gln Thr Thr Lys Leu Glu Lys Tyr Ser 
465                 470                 475             


<210>  359
<211>  482
<212>  PRT
<213>  Clostridium botulinum

<400>  359

Met Asn Thr Val Arg Lys Ile Lys Leu Thr Ile Leu Gly Asp Thr Glu 
1               5                   10                  15      


Thr Arg Asn Lys Gln Tyr Lys Trp Ile Arg Asp Glu Gln Tyr Asn Gln 
            20                  25                  30          


Tyr Arg Ala Leu Asn Leu Ser Met Thr Tyr Met Val Thr Asn Leu Met 
        35                  40                  45              


Leu Lys Asn Asn Glu Ser Gly Leu Glu Asn Arg Lys Glu Lys Asp Val 
    50                  55                  60                  


Leu Lys Ile Glu Asn Lys Ile Lys Lys Asp Glu Glu Asn Leu Lys Lys 
65                  70                  75                  80  


Glu Leu Ala Lys Lys Lys Ile Asn Glu Glu Lys Ile Glu Asn Ile Asn 
                85                  90                  95      


Ser Asn Ile Glu Glu Leu Lys Ser Glu Lys Glu Lys Leu Glu Asn Glu 
            100                 105                 110         


Leu Lys Asn Ile Lys Glu Tyr Arg Ser Asn Ile Asp Glu Glu Phe Lys 
        115                 120                 125             


Lys Met Tyr Val Asp Asp Leu Tyr Asn Val Leu Ser Lys Ile Ser Phe 
    130                 135                 140                 


Gln His Glu Asp Met Lys Ser Leu Val Thr Gln Arg Val Lys Lys Asp 
145                 150                 155                 160 


Phe Asn Asn Asp Val Lys Glu Ile Met Arg Gly Asp Arg Ser Val Arg 
                165                 170                 175     


Asn Tyr Lys Arg Asn Phe Pro Ile Leu Thr Arg Gly Arg Asp Leu Lys 
            180                 185                 190         


Phe Gln Tyr Phe Glu Lys Ser Glu Asp Ile Glu Ile Lys Trp Ile Glu 
        195                 200                 205             


Gly Ile Lys Phe Lys Cys Ile Leu Gly Lys Pro Ser Lys Ser Leu Glu 
    210                 215                 220                 


Leu Lys His Thr Leu His Lys Val Ile Asn Glu Glu Tyr Lys Ile Cys 
225                 230                 235                 240 


Asp Ser Ser Leu Gln Phe Asp Lys Asn Asn Asn Leu Ile Leu Asn Leu 
                245                 250                 255     


Thr Leu Asp Ile Pro Glu Asn Asn Lys Tyr Glu Lys Ile Glu Asn Arg 
            260                 265                 270         


Ile Val Gly Val Asp Leu Gly Leu Lys Ile Pro Ala Tyr Val Ala Leu 
        275                 280                 285             


Asn Asp Thr Ile Tyr Ile Arg Lys Ser Ile Gly Ser Ile Asn Asp Phe 
    290                 295                 300                 


Leu Lys Val Arg Thr Gln Ile Gln Ser Arg Ala Arg Lys Leu Gln Lys 
305                 310                 315                 320 


Ser Leu Gln Val Val Arg Gly Gly Lys Gly Arg Asn Lys Lys Met Lys 
                325                 330                 335     


Ala Leu Glu Arg Phe Arg Glu Lys Glu Arg Asn Phe Ala Arg Asn Tyr 
            340                 345                 350         


Asn His Phe Leu Ser Tyr Asn Ile Val Lys Phe Ala Leu Asp Asn Lys 
        355                 360                 365             


Ala Glu Gln Ile Asn Leu Glu Leu Leu Glu Met Lys Lys Thr Gln Asn 
    370                 375                 380                 


Lys Ser Ile Leu Arg Asn Trp Ser Tyr Tyr Gln Leu Gln Ser Phe Ile 
385                 390                 395                 400 


Glu Tyr Lys Ala Glu Arg Val Gly Ile Lys Val Lys Tyr Ile Asp Pro 
                405                 410                 415     


Tyr His Thr Ser Gln Thr Cys Ser Glu Cys Gly Asn Tyr Glu Glu Gly 
            420                 425                 430         


Gln Arg Val Glu Gln Asp Thr Phe Val Cys Lys Arg Cys Gly His Lys 
        435                 440                 445             


Ile Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Met Ser Asp Lys 
    450                 455                 460                 


Tyr Ile Ser Lys Lys Glu Glu Ser Glu Tyr Tyr Lys Asn Asn Lys Asn 
465                 470                 475                 480 


Met Val 
        


<210>  360
<211>  482
<212>  PRT
<213>  Clostridium botulinum

<400>  360

Met Asn Thr Val Arg Lys Ile Lys Leu Thr Ile Leu Gly Asp Thr Glu 
1               5                   10                  15      


Thr Arg Asn Lys Gln Tyr Lys Trp Ile Lys Asp Glu Gln Tyr Asn Gln 
            20                  25                  30          


Tyr Arg Ala Leu Asn Leu Ser Met Thr Tyr Met Val Thr Asn Leu Met 
        35                  40                  45              


Leu Lys Asn Asn Glu Ser Gly Leu Glu Asn Arg Lys Glu Lys Asp Ile 
    50                  55                  60                  


Leu Lys Ile Glu Asn Lys Ile Lys Lys Asp Glu Gly Ser Leu Lys Lys 
65                  70                  75                  80  


Glu Leu Ala Lys Lys Lys Ile Asn Glu Glu Lys Ile Glu Asn Ile Lys 
                85                  90                  95      


Ser Asn Ile Glu Glu Leu Lys Ser Glu Lys Glu Lys Leu Glu Asn Glu 
            100                 105                 110         


Leu Lys Asn Ile Lys Glu Tyr Arg Ser Asn Ile Asp Glu Glu Phe Lys 
        115                 120                 125             


Lys Met Tyr Val Asp Asp Leu Tyr Asn Val Leu Asn Lys Ile Ser Phe 
    130                 135                 140                 


Gln His Glu Asp Met Lys Ser Leu Val Thr Gln Arg Val Lys Lys Asp 
145                 150                 155                 160 


Phe Asn Asn Asp Val Lys Glu Ile Met Arg Gly Asp Arg Ser Val Arg 
                165                 170                 175     


Asn Tyr Lys Arg Asn Phe Pro Ile Leu Thr Arg Gly Arg Asp Leu Lys 
            180                 185                 190         


Phe Gln Tyr Ile Glu Lys Ser Glu Asp Ile Glu Ile Lys Trp Ile Glu 
        195                 200                 205             


Gly Ile Lys Phe Lys Cys Ile Leu Gly Lys Pro Ser Lys Ser Leu Glu 
    210                 215                 220                 


Leu Lys His Ala Leu His Lys Val Ile Asn Lys Glu Tyr Lys Val Cys 
225                 230                 235                 240 


Asp Ser Ser Leu Gln Phe Asp Lys Asn Asn Asn Leu Ile Leu Asn Leu 
                245                 250                 255     


Thr Leu Asp Ile Pro Gln Asp Asn Lys Tyr Glu Lys Ile Thr Asn Arg 
            260                 265                 270         


Val Val Gly Val Asp Leu Gly Leu Lys Ile Pro Ala Tyr Val Ala Leu 
        275                 280                 285             


Asn Asp Thr Lys Tyr Ile Arg Lys Ala Ile Gly Ser Ile Asp Asp Phe 
    290                 295                 300                 


Leu Lys Val Arg Thr Gln Met Gln Ser Arg Val Arg Lys Leu Gln Lys 
305                 310                 315                 320 


Ser Leu Gln Val Val Arg Gly Gly Lys Gly Arg Asn Lys Lys Met Lys 
                325                 330                 335     


Ala Leu Glu Arg Phe Arg Glu Lys Glu Arg Asn Phe Ala Arg Asn Tyr 
            340                 345                 350         


Asn His Phe Leu Ser Tyr Asn Ile Val Lys Phe Ala Leu Asp Asn Lys 
        355                 360                 365             


Ala Glu Gln Ile Asn Leu Glu Leu Leu Glu Met Lys Lys Thr Gln Asn 
    370                 375                 380                 


Lys Ser Ile Leu Arg Asn Trp Ser Tyr Tyr Gln Leu Gln Asn Phe Ile 
385                 390                 395                 400 


Glu Tyr Lys Ala Glu Arg Val Gly Ile Lys Val Lys Tyr Ile Asp Pro 
                405                 410                 415     


Tyr His Thr Ser Gln Thr Cys Ser Glu Cys Gly Asn Tyr Glu Glu Gly 
            420                 425                 430         


Gln Arg Val Glu Gln Asp Thr Phe Val Cys Lys Arg Cys Trp His Lys 
        435                 440                 445             


Met Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Met Ser Tyr Asn 
    450                 455                 460                 


Tyr Ile Ser Lys Lys Glu Glu Ser Glu Tyr Tyr Lys Asn Asn Lys Asn 
465                 470                 475                 480 


Met Val 
        


<210>  361
<211>  482
<212>  PRT
<213>  Clostridium botulinum

<400>  361

Met Asn Thr Val Arg Lys Ile Lys Leu Thr Ile Leu Gly Asp Thr Glu 
1               5                   10                  15      


Thr Arg Asn Lys Gln Tyr Lys Trp Ile Arg Asp Glu Gln Tyr Asn Gln 
            20                  25                  30          


Tyr Arg Ala Leu Asn Leu Ser Met Thr Tyr Met Val Thr Asn Leu Met 
        35                  40                  45              


Leu Lys Asn Asn Glu Ser Gly Leu Glu Asn Arg Lys Glu Lys Asp Ile 
    50                  55                  60                  


Leu Lys Ile Glu Asn Lys Ile Lys Lys Asp Glu Glu Asn Leu Lys Lys 
65                  70                  75                  80  


Glu Leu Ala Lys Lys Lys Ile Asn Glu Glu Lys Ile Glu Asn Ile Lys 
                85                  90                  95      


Ser Asn Ile Glu Glu Leu Lys Ser Glu Lys Glu Lys Leu Glu Asn Glu 
            100                 105                 110         


Leu Lys Asn Ile Lys Glu Tyr Arg Ser Asn Ile Asp Glu Glu Phe Lys 
        115                 120                 125             


Lys Met Tyr Val Asp Asp Leu Tyr Asn Val Leu Asn Lys Ile Ser Phe 
    130                 135                 140                 


Gln His Glu Asp Met Lys Ser Leu Val Thr Gln Arg Val Lys Lys Asp 
145                 150                 155                 160 


Phe Asn Asn Asp Ile Lys Glu Ile Met Arg Gly Asp Arg Ser Val Arg 
                165                 170                 175     


Asn Tyr Lys Arg Asn Phe Pro Val Leu Thr Arg Gly Arg Asp Leu Lys 
            180                 185                 190         


Phe Lys Tyr Phe Glu Lys Ser Glu Asp Ile Glu Ile Lys Trp Ile Glu 
        195                 200                 205             


Gly Ile Lys Phe Lys Cys Ile Leu Gly Arg Pro Ser Lys Ser Leu Glu 
    210                 215                 220                 


Leu Lys His Thr Leu His Lys Val Ile Asn Glu Glu Tyr Lys Ile Cys 
225                 230                 235                 240 


Asp Ser Ser Leu Gln Phe Asp Lys Asn Asn Asn Leu Ile Leu Asn Leu 
                245                 250                 255     


Thr Leu Asp Ile Pro Glu Asn Asn Lys Tyr Glu Lys Ile Glu Asn Arg 
            260                 265                 270         


Ile Val Gly Val Asp Leu Gly Leu Lys Ile Pro Ala Tyr Val Ala Leu 
        275                 280                 285             


Asn Asp Thr Arg Tyr Ile Arg Lys Ser Ile Gly Ser Ile Asn Asp Phe 
    290                 295                 300                 


Leu Lys Val Arg Thr Gln Ile Gln Ser Arg Ala Arg Lys Leu Gln Lys 
305                 310                 315                 320 


Ser Leu Gln Val Val Arg Gly Gly Lys Gly Arg Asn Lys Lys Met Lys 
                325                 330                 335     


Ala Leu Glu Arg Phe Arg Glu Lys Glu Arg Asn Phe Ala Arg Asn Tyr 
            340                 345                 350         


Asn His Phe Leu Ser Tyr Asn Ile Val Lys Phe Ala Leu Asp Asn Lys 
        355                 360                 365             


Ala Glu Gln Ile Asn Leu Glu Leu Leu Glu Met Lys Lys Thr Gln Asn 
    370                 375                 380                 


Lys Ser Ile Leu Arg Asn Trp Ser Tyr Tyr Gln Leu Gln Thr Phe Ile 
385                 390                 395                 400 


Glu Tyr Lys Ala Glu Arg Val Gly Ile Lys Val Lys Tyr Ile Asp Pro 
                405                 410                 415     


Tyr His Thr Ser Gln Thr Cys Ser Glu Cys Gly Asn Tyr Glu Glu Gly 
            420                 425                 430         


Gln Arg Val Glu Gln Asp Thr Phe Val Cys Lys Arg Cys Gly His Lys 
        435                 440                 445             


Ile Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Met Ser Asp Asn 
    450                 455                 460                 


Tyr Ile Ser Lys Lys Glu Glu Ser Glu Tyr Tyr Lys Asn Asn Lys Asn 
465                 470                 475                 480 


Met Val 
        


<210>  362
<211>  486
<212>  PRT
<213>  Hydrogenivirga sp.

<400>  362

Met Asn Lys Val Leu Lys Leu Thr Ala Lys Arg Glu Lys Val Lys Phe 
1               5                   10                  15      


Lys Leu Leu Leu Leu Glu Thr Gly Arg Glu Glu Glu Val Lys Phe Tyr 
            20                  25                  30          


Glu Leu Arg Glu Ala Leu Glu Arg Phe Val Arg Gly Val Arg Val Ala 
        35                  40                  45              


Tyr Leu Lys Thr Leu Pro Asp Ser Leu Glu Gly Leu Glu Glu Lys Gly 
    50                  55                  60                  


Arg Pro Asn Thr Arg Ala Val Asn Ser Asn Glu Leu Ser Lys Arg Phe 
65                  70                  75                  80  


Pro Pro Glu Cys Ala Lys Val Lys Leu Gly Ser Leu Glu Leu Glu Leu 
                85                  90                  95      


Gly Lys Asp Asn Ile Ala Ser Ser Ile Arg Tyr Thr Ile Glu Lys Asp 
            100                 105                 110         


Ile Arg Glu Asn Leu Lys Arg Glu Phe Lys Thr Ile Ala Ile Lys Ser 
        115                 120                 125             


Val Pro Ile Ile Ala Arg Val His Thr Thr Lys Ser His Pro Tyr Glu 
    130                 135                 140                 


Lys Ala Phe Gly Glu Val Phe Arg Ile Phe Glu Ile Ser Glu Pro Asp 
145                 150                 155                 160 


Glu Lys Asn Arg Val Ser Val Arg Val Gly Val Lys Phe Phe Lys Gln 
                165                 170                 175     


Val Glu Val Glu Gly Lys Lys Ala Thr Pro Val Leu Val Val Glu Ala 
            180                 185                 190         


Val Met Arg Leu Lys Gly Arg Asp Tyr Ala Thr Ala Asn Ser Tyr Tyr 
        195                 200                 205             


Asn Ile Leu Lys Arg Ile Lys Glu Gly Glu Tyr Lys Val Ala Tyr Ala 
    210                 215                 220                 


Gly Leu Ser Tyr Arg Glu Gly Ser Gly Ile Ser Leu Leu Leu Ser Tyr 
225                 230                 235                 240 


Asn Leu Pro Asp Ile Ser Glu Asp Asp Lys Arg Glu Asn Ile Leu Gly 
                245                 250                 255     


Ile Asp Leu Gly Gln Ala Cys Pro Val Tyr Trp Ser Leu Ile Thr Pro 
            260                 265                 270         


Glu Leu Glu Lys Lys Lys Leu Thr Asn Gly Arg His Pro Arg Gly Gln 
        275                 280                 285             


Ile Glu Tyr Pro Val Asn Leu Glu Gly Ala Ile Arg Lys Leu Trp Arg 
    290                 295                 300                 


Ala Lys Arg Asn Leu Leu Ser Ser Leu Arg Arg Ile Glu Glu Gln Thr 
305                 310                 315                 320 


Ser Leu Leu Ser Glu Gly Asn Arg Asp Leu Lys Gly Arg Leu Leu Arg 
                325                 330                 335     


Arg Lys Arg Glu Val Glu Arg Ser Leu Lys Gly Met Arg Arg Lys Glu 
            340                 345                 350         


Lys Asn Leu Met Lys Lys Met Asp Glu Phe Leu Ala Asn Glu Val Ile 
        355                 360                 365             


Arg Val Ala Leu Arg Glu Arg Cys Arg Lys Ile Arg Met Glu Arg Leu 
    370                 375                 380                 


Asp Gly Val Asp Lys Thr Glu Leu Tyr Phe Pro Lys Trp Asn Tyr Gly 
385                 390                 395                 400 


Gln Leu Gln Asn Leu Ile Glu Gln Arg Ala Ser Leu Tyr Gly Ile Glu 
                405                 410                 415     


Val Glu Arg Val Asn Pro Arg Lys Thr Ser Gln Arg Cys Pro Ser Cys 
            420                 425                 430         


Gly Tyr Val Gly Gln Arg Arg Glu Glu Val Arg Pro Thr Arg Asp Leu 
        435                 440                 445             


Phe Arg Cys Pro Glu Cys Gly Glu Glu Ser Phe Ala Asp Phe Val Gly 
    450                 455                 460                 


Ala Phe Asn Val Gly Ile Gly Gly Trp Glu Ala Phe Lys Pro Lys Glu 
465                 470                 475                 480 


Ala Leu Ser Ser Ser Ser 
                485     


<210>  363
<211>  489
<212>  PRT
<213>  Bacillus megaterium

<400>  363

Met Ile Thr Thr Arg Lys Phe Lys Leu Ala Ile Val Ser Asp Asn Arg 
1               5                   10                  15      


Asn Glu Ala Tyr Ser Phe Ile Arg Asn Glu Ile Arg Asn Gln Asn Lys 
            20                  25                  30          


Ala Leu Asn Ala Ala Tyr Asn His Leu Tyr Phe Glu His Ile Ala Thr 
        35                  40                  45              


Glu Lys Leu Lys His Ser Asp Ala Glu Tyr Gln Lys His Leu Thr Lys 
    50                  55                  60                  


Tyr Arg Glu Val Ala Thr Asn Lys Tyr Gln Asp Tyr Leu Lys Ala Lys 
65                  70                  75                  80  


Glu Lys Val Asn Ala Ser Lys Asp Asp Glu Lys Leu Gln Lys Arg Val 
                85                  90                  95      


Asp Lys Ala Arg Glu Ala Tyr Asn Lys Ala Gln Glu Lys Val Tyr Lys 
            100                 105                 110         


Ile Glu Lys Glu Phe Asn Lys Lys Ser Met Glu Thr Tyr Gln Lys Val 
        115                 120                 125             


Val Gly Leu Ser Lys Gln Thr Arg Ile Gly Lys Leu Leu Lys Ser Gln 
    130                 135                 140                 


Phe Thr Leu His Tyr Asp Thr Glu Asp Arg Ile Thr Ser Thr Val Leu 
145                 150                 155                 160 


Ser His Phe Asn Asn Asp Met Lys Thr Gly Val Leu Arg Gly Asp Arg 
                165                 170                 175     


Ser Leu Arg Thr Tyr Lys Asn Ser His Pro Leu Leu Val Arg Ala Arg 
            180                 185                 190         


Ser Met Lys Val Tyr Glu Glu Asn Gly Asp Tyr Phe Ile Lys Trp Val 
        195                 200                 205             


Lys Gly Ile Val Phe Lys Ile Val Ile Ser Ala Gly Ser Lys Gln Lys 
    210                 215                 220                 


Ala Asn Ile Gly Glu Leu Lys Ser Val Leu Ile Asn Ile Leu Asn Gly 
225                 230                 235                 240 


His Tyr Lys Val Cys Asp Ser Ser Ile Ser Leu Asn Lys Asp Leu Ile 
                245                 250                 255     


Leu Asn Leu Ser Leu Asn Ile Pro Val Ser Lys Glu Asn Val Phe Val 
            260                 265                 270         


Pro Gly Arg Val Val Gly Val Asp Leu Gly Leu Lys Ile Pro Ala Tyr 
        275                 280                 285             


Val Ser Leu Asn Asp Thr Pro Tyr Ile Lys Lys Gly Ile Gly Asn Ile 
    290                 295                 300                 


Asp Asp Phe Leu Arg Val Arg Thr Gln Leu Gln Ser Gln Arg Lys Arg 
305                 310                 315                 320 


Leu Gln Lys Thr Leu Glu Cys Thr Ser Gly Gly Lys Gly Arg Ser Lys 
                325                 330                 335     


Lys Leu Lys Gly Leu Asp Arg Leu Lys Ala Lys Glu Lys Asn Phe Val 
            340                 345                 350         


Asn Thr Tyr Asn His Phe Leu Ser Lys Lys Ile Ile Gln Phe Ala Val 
        355                 360                 365             


Lys Asn Asn Ala Gly Val Ile His Leu Glu Glu Leu Gln Phe Asp Lys 
    370                 375                 380                 


Leu Lys His Lys Ser Leu Leu Arg Asn Trp Ser Tyr Tyr Gln Leu Gln 
385                 390                 395                 400 


Thr Met Ile Glu Tyr Lys Ala Glu Arg Glu Gly Ile Glu Val Lys Tyr 
                405                 410                 415     


Val Asp Ala Ser Tyr Thr Ser Gln Thr Cys Ser Lys Cys Gly His Tyr 
            420                 425                 430         


Glu Glu Gly Gln Arg Val Leu Gln Asp Thr Phe Thr Cys Lys Asn Lys 
        435                 440                 445             


Glu Cys Lys Gly Tyr Val His Lys Val Asn Ala Asp Phe Asn Ala Ser 
    450                 455                 460                 


Gln Asn Ile Ala Lys Ser Thr Asp Ile Ile Arg Cys Thr Glu Met Ala 
465                 470                 475                 480 


Lys Asn Asn Asp Ile Glu Lys Asn Ala 
                485                 


<210>  364
<211>  491
<212>  PRT
<213>  Clostridium fallax

<400>  364

Met Ile Thr Val Arg Lys Leu Lys Leu Ser Ile Met Ala Asp Glu Glu 
1               5                   10                  15      


Leu Arg Ile Gln Gln Leu Lys Trp Ile Lys Asp Glu Gln Tyr Asn Gln 
            20                  25                  30          


Tyr Arg Ala Leu Asn Asn Gly Met Ala Phe Leu Ile Ala Asp His Met 
        35                  40                  45              


Leu Asn Thr Ala Glu Ser Thr Lys Ile Ile Tyr Lys Asn Asn Glu Ile 
    50                  55                  60                  


Asn Lys Lys Lys Lys Lys Ile Tyr Tyr Met Glu Asp Lys Ile Lys Lys 
65                  70                  75                  80  


Glu Asn Asn Lys Leu Glu Glu Glu Lys Ile Leu Lys Phe Glu Ser Asp 
                85                  90                  95      


Ile Asn Lys Leu Lys His Glu Ile Lys Ile Leu Glu Asn Glu Lys Val 
            100                 105                 110         


Glu Leu Glu Leu Glu Thr Lys Asn Leu Ser Glu Gln Phe Lys Asn His 
        115                 120                 125             


Tyr Val Glu Asp Met Tyr Thr Arg Leu Asp Glu Ile Pro Phe Gln Tyr 
    130                 135                 140                 


Lys Asp Asn Lys Ser Leu Val Gln Asn Arg Leu Lys Lys Asp Phe Asp 
145                 150                 155                 160 


Phe Tyr Leu Asn Asn Gly Gly Lys Arg Gly Glu Arg Lys Pro Thr Ala 
                165                 170                 175     


Tyr Lys Arg Asp Tyr Pro Leu Leu Ile Arg Gly Arg Leu Leu Asn Phe 
            180                 185                 190         


Tyr Tyr Asn Lys Asp Asn Val Phe Ile Lys Trp Ile Ala Gly Ile Thr 
        195                 200                 205             


Phe Lys Val Glu Leu Gly Asn Lys Ile Lys Asn Asn Ile Glu Leu Arg 
    210                 215                 220                 


His Thr Leu His Gln Cys Met Asn Asn Glu Lys Tyr Lys Val Cys Asp 
225                 230                 235                 240 


Ser Ser Leu Gln Phe Asp Asn Lys Asn Asn Ile Ile Leu Asn Leu Thr 
                245                 250                 255     


Ile Asp Ile Pro Ile Asn Thr Ser Glu Asn Asn Phe Ile Glu Gly Arg 
            260                 265                 270         


Val Met Gly Val Asp Leu Gly Met Lys Ile Pro Ala Tyr Ala Ser Phe 
        275                 280                 285             


Asn Asp Val Glu Tyr Cys Arg Ala Phe Gly Asp Ile Glu Asp Phe Leu 
    290                 295                 300                 


Arg Val Arg Thr Gln Leu Gln Ser Arg Met Arg Lys Leu Gln Met Ala 
305                 310                 315                 320 


Leu Thr Leu Ile Lys Gly Gly His Gly Arg Gly Lys Lys Leu Gln Ala 
                325                 330                 335     


Leu Asn Arg Leu Lys Asp Lys Glu Lys Asp Phe Val Asn Thr Tyr Asn 
            340                 345                 350         


His Met Ile Ser Lys Arg Ile Ile Glu Tyr Ser Ile Lys Asn Cys Cys 
        355                 360                 365             


Gly Val Ile Asn Leu Glu Tyr Leu Ser Leu Ala Ala Arg Glu Lys Asp 
    370                 375                 380                 


Leu Phe Leu Thr Leu Gln Pro Gln Lys Ser Asn Arg Ile Lys Arg Asn 
385                 390                 395                 400 


Trp Ser Tyr Tyr Asp Leu Gln Thr Lys Ile Glu Asn Lys Ala Lys Lys 
                405                 410                 415     


Tyr Gly Ile Ile Val Lys Lys Ile Asp Pro Tyr Leu Thr Ser Gln Thr 
            420                 425                 430         


Cys His Ile Cys Gly Asn Tyr Asp Glu Gly Gln Arg Ile Ser Gln Glu 
        435                 440                 445             


Gln Phe Glu Cys Lys Ala Cys Asn Arg Lys Phe Asn Ala Asp Tyr Asn 
    450                 455                 460                 


Ala Ser Lys Asn Ile Ala Leu Ser Thr Lys Tyr Ile Asn Asn Ile Asn 
465                 470                 475                 480 


Glu Ser Glu Phe Phe Lys Arg Tyr Lys Asn Asn 
                485                 490     


<210>  365
<211>  492
<212>  PRT
<213>  Bacteroides plebeius

<400>  365

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Lys Ile Val Lys Asp Arg 
1               5                   10                  15      


Leu Thr Asp Glu Lys Glu Arg Leu Thr Asp Glu Lys Tyr Asp Gln Gln 
            20                  25                  30          


Trp Lys Tyr Leu Tyr Gln Ile Asn Asn Thr Ile Tyr Gln Ala Ala Asn 
        35                  40                  45              


Arg Ile Ser Thr His Cys Leu Phe Asn Asp Glu Tyr Glu Met Arg Leu 
    50                  55                  60                  


Lys Leu His Met Pro Arg Tyr Lys Asp Ile Glu Lys Lys Leu Glu Glu 
65                  70                  75                  80  


Ile Glu Lys Lys Gln Lys Gly Leu Asn Thr Lys Lys Lys Ala Ser Asp 
                85                  90                  95      


Lys Glu Glu Arg Asp Arg Leu Leu Asn Glu Lys Gln Gln Leu Val Asn 
            100                 105                 110         


Glu Arg Lys Glu Ile Asp Glu Asp Val Lys Asn Lys Lys Lys Asp Phe 
        115                 120                 125             


Leu Gln Cys Ser Lys Gln Asn Ser Thr Tyr Gln Leu Val Ser Lys Glu 
    130                 135                 140                 


Phe Lys Gln Tyr Ile Pro Ser Asp Ile Leu Ala Asn Leu Asn Gln Lys 
145                 150                 155                 160 


Ile Gln Glu Asn Tyr Asn Asn Asn Gln Lys Lys Ile Glu Ser Gly Glu 
                165                 170                 175     


Arg Ala Leu Ser Thr Tyr Lys Lys Gly Met Glu Ile Pro Phe Ser Ile 
            180                 185                 190         


Arg Glu Asn Lys Arg Leu Lys Leu Phe Ile Lys Glu Glu Gly Ile Tyr 
        195                 200                 205             


Leu Lys Trp Phe Lys Glu Ile Leu Phe Arg Leu Glu Phe Gly Lys Asp 
    210                 215                 220                 


Ala Ser Asn Asn Arg Cys Ile Val Glu Arg Leu Ile Glu Ser Asp Lys 
225                 230                 235                 240 


Gln Gln Lys Gly Lys Gly Glu Asp Tyr Val Ala Asn Asn Ser Ser Ile 
                245                 250                 255     


Lys Leu Val Lys Asn Gly Lys Asn Thr Arg Ile Phe Leu Leu Leu Ser 
            260                 265                 270         


Ile Asp Ile Pro Ala Lys Lys Gln Val Leu Asp Lys Glu Val Val Leu 
        275                 280                 285             


Gly Val Asp Leu Gly Ile Lys Cys Pro Leu Tyr Leu Ala Ile Asn Lys 
    290                 295                 300                 


Asn Asp Asn Phe Lys Met Gln Ile Gly Asp Ile Glu His Phe His Asn 
305                 310                 315                 320 


Gln Arg Thr Met Phe Gln Lys Arg Phe Lys Ser Leu Gln Lys Leu Ile 
                325                 330                 335     


Cys Thr Gln Gly Ala His Gly Arg Lys Lys Lys Leu Glu Pro Leu Glu 
            340                 345                 350         


Lys Leu Lys Glu Lys Glu Arg Asn Trp Val His Thr Gln Asn His Val 
        355                 360                 365             


Tyr Ser Arg Glu Val Ile Lys Gln Ala Leu Lys Gln Asn Ala Gly Thr 
    370                 375                 380                 


Ile His Met Glu Ser Leu Lys Asp Phe Gly Lys Gly Lys Asp Gly Tyr 
385                 390                 395                 400 


Val Lys Asp Glu Tyr Lys Tyr Leu Leu Arg Tyr Trp Ser Tyr Tyr Glu 
                405                 410                 415     


Leu Gln Ser Met Ile Glu Tyr Lys Ala Lys Leu Glu Gly Ile Glu Val 
            420                 425                 430         


Lys Tyr Ile Asp Pro Ala Tyr Thr Ser Gln Thr Cys Ser Tyr Cys Gly 
        435                 440                 445             


Glu Arg Gly Glu Arg Lys Lys Gln Glu Glu Phe Ile Cys Thr Asn Pro 
    450                 455                 460                 


Gln Cys Lys Arg Arg Gly Glu Lys Ile Asn Ala Asp Phe Asn Ala Ala 
465                 470                 475                 480 


Arg Asn Ile Ala Met Ser Lys Lys Ile Val Glu Arg 
                485                 490         


<210>  366
<211>  496
<212>  PRT
<213>  Bacillus thuringiensis

<400>  366

Met Ile Leu Thr Arg Lys Val Lys Leu Val Ile Val Ser Asp Asn Arg 
1               5                   10                  15      


Asp Glu Gly Tyr Lys Leu Ile Arg Asn Glu Ile Arg Glu Gln His Lys 
            20                  25                  30          


Ala Leu Asn Leu Ala Tyr Asn His Leu Tyr Phe Glu His Asn Ala Ile 
        35                  40                  45              


Gln Ile Leu Lys Gln Asn Asp Glu Asp Tyr Lys Gln Lys Arg Asn Lys 
    50                  55                  60                  


Leu Gln Glu Leu Ile Asn Lys Lys Tyr Glu Glu His Gln Lys Ala Lys 
65                  70                  75                  80  


Asn Leu Glu Arg Lys Glu Ala Leu Arg Glu Ala Tyr Asn Asn Lys Lys 
                85                  90                  95      


Gln Glu Leu Tyr Lys Phe Glu Arg Glu Cys Asn Glu Glu Ala Arg Lys 
            100                 105                 110         


Ala Tyr Gln Gln Val Val Gly Phe Thr Gln Gln Thr Arg Val Arg Asn 
        115                 120                 125             


Leu Ile Asn Arg Glu Tyr Asn Leu Met Ser Asp Thr Lys Asp Gly Ile 
    130                 135                 140                 


Thr Ser Lys Val Thr Gln Asp Tyr Lys Asn Asp Cys Lys Ala Gly Leu 
145                 150                 155                 160 


Leu Ile Gly Lys Arg Ser Leu Arg Asn Tyr Lys Lys Asp Asn Pro Leu 
                165                 170                 175     


Leu Val Arg Gly Arg Ser Leu Lys Phe Tyr Lys Glu Asp Gly Asp Tyr 
            180                 185                 190         


Phe Ile Lys Trp Asn Lys Gly Thr Val Phe Lys Cys Ile Leu His Ile 
        195                 200                 205             


Arg Lys Lys Asn Val Ala Glu Leu Gln Ser Val Leu Glu Asn Val Leu 
    210                 215                 220                 


Leu Gly Ala Tyr Lys Ile Cys Asp Ser Ser Ile Gly Phe Asn Asn Lys 
225                 230                 235                 240 


Asp Met Ile Leu Asn Leu Ser Leu Asn Ile Pro Asp Lys Glu Thr Tyr 
                245                 250                 255     


Asp Tyr Ile Pro Gly Arg Val Val Gly Val Asp Leu Gly Leu Lys Ile 
            260                 265                 270         


Pro Ala Tyr Val Ser Leu Ser Asp Lys Val Tyr Val Arg Lys Gly Ile 
        275                 280                 285             


Gly Gly Ile Asp Asp Phe Leu Arg Val Arg Thr Gln Met Gln Lys Arg 
    290                 295                 300                 


Arg Arg Gln Leu Gln Glu Ser Leu Ala Ala Val Lys Gly Gly Lys Gly 
305                 310                 315                 320 


Arg Glu Lys Lys Leu Lys Ala Leu Asp His Leu Lys Gly Lys Glu Ala 
                325                 330                 335     


Asn Phe Ala Lys Thr Tyr Asn His Phe Leu Ser Thr Gln Ile Val Thr 
            340                 345                 350         


Phe Ala Val Lys Asn Gln Ala Gly Gln Ile Asn Met Glu Phe Leu Glu 
        355                 360                 365             


Phe Asp Lys Met Lys Asn Lys Ser Leu Leu Arg Asn Trp Ser Tyr Tyr 
    370                 375                 380                 


Gln Leu Gln Met Met Val Glu Tyr Lys Ala Lys Arg Glu Gly Ile Ile 
385                 390                 395                 400 


Ile Lys Tyr Val Asp Ala Tyr Leu Thr Ser Gln Thr Cys Ser Lys Cys 
                405                 410                 415     


Asp Tyr Tyr Glu Glu Gly Gln Arg Glu Lys Gln Glu Lys Phe Ile Cys 
            420                 425                 430         


Lys Ser Cys Ala Phe Glu Val Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
        435                 440                 445             


Ile Ala Lys Ser Ala Arg Tyr Ile Ser Asp Ser Thr Glu Arg Glu Tyr 
    450                 455                 460                 


His Lys Lys Lys Gln Glu Asp Leu Lys Glu Ile Leu Gly Glu Asn Asp 
465                 470                 475                 480 


Ile Ile Asn Glu Gln Leu Ser Leu Phe Asp Asn His Asp Asp Ile Ala 
                485                 490                 495     


<210>  367
<211>  496
<212>  PRT
<213>  Bacillus cereus

<400>  367

Met Ile Leu Thr Arg Lys Val Lys Leu Val Ile Val Ser Asp Asn Arg 
1               5                   10                  15      


Asp Glu Gly Tyr Lys Leu Ile Arg Asn Glu Ile Arg Glu Gln His Lys 
            20                  25                  30          


Ala Leu Asn Leu Ala Tyr Asn His Leu Tyr Phe Glu His Asn Ala Ile 
        35                  40                  45              


Gln Ile Leu Lys Gln Asn Asp Glu Asp Tyr Lys Gln Lys Arg Asn Lys 
    50                  55                  60                  


Leu Gln Glu Leu Ile Asn Lys Lys Tyr Glu Glu His Gln Lys Ala Lys 
65                  70                  75                  80  


Asn Leu Glu Arg Lys Glu Ala Leu Arg Glu Ala Tyr Asn Asn Lys Lys 
                85                  90                  95      


Gln Glu Leu Tyr Lys Phe Glu Arg Glu Cys Asn Glu Glu Ala Arg Lys 
            100                 105                 110         


Ala Tyr Gln Gln Val Val Gly Phe Thr Gln Gln Thr Arg Val Arg Asn 
        115                 120                 125             


Leu Ile Asn Arg Glu Cys Asn Leu Met Ser Asp Thr Lys Asp Gly Ile 
    130                 135                 140                 


Thr Ser Lys Val Thr Gln Asp Tyr Lys Asn Asp Cys Lys Ala Gly Leu 
145                 150                 155                 160 


Leu Ile Gly Lys Arg Ser Leu Arg Asn Tyr Lys Lys Asp Asn Pro Leu 
                165                 170                 175     


Leu Val Arg Gly Arg Ser Leu Lys Phe Tyr Lys Glu Asp Gly Asp Tyr 
            180                 185                 190         


Phe Ile Lys Trp Asn Lys Gly Thr Val Phe Lys Cys Ile Leu His Ile 
        195                 200                 205             


Arg Lys Lys Asn Val Ala Glu Leu Gln Ser Val Leu Glu Asn Val Leu 
    210                 215                 220                 


Leu Gly Ala Tyr Lys Ile Cys Asp Ser Ser Ile Gly Phe Asn Asn Lys 
225                 230                 235                 240 


Asp Met Ile Leu Asn Leu Ser Leu Asn Ile Pro Asp Lys Glu Thr Tyr 
                245                 250                 255     


Asp Tyr Ile Pro Gly Arg Val Val Gly Val Asp Leu Gly Leu Lys Ile 
            260                 265                 270         


Pro Ala Tyr Val Ser Leu Ser Asp Lys Val Tyr Val Arg Lys Gly Ile 
        275                 280                 285             


Gly Gly Ile Asp Asp Phe Leu Arg Val Arg Thr Gln Met Gln Lys Arg 
    290                 295                 300                 


Arg Arg Gln Leu Gln Glu Ser Leu Ala Ala Val Lys Gly Gly Lys Gly 
305                 310                 315                 320 


Arg Glu Lys Lys Leu Lys Ala Leu Asp His Leu Lys Gly Lys Glu Ala 
                325                 330                 335     


Asn Phe Ala Lys Thr Tyr Asn His Phe Leu Ser Thr Gln Ile Val Thr 
            340                 345                 350         


Phe Ala Val Lys Asn Gln Ala Gly Gln Ile Asn Met Glu Phe Leu Glu 
        355                 360                 365             


Phe Asp Lys Met Lys Asn Lys Ser Leu Leu Arg Asn Trp Ser Tyr Tyr 
    370                 375                 380                 


Gln Leu Gln Met Met Val Glu Tyr Lys Ala Lys Arg Glu Gly Ile Ile 
385                 390                 395                 400 


Ile Lys Tyr Val Asp Ala Tyr Leu Thr Ser Gln Thr Cys Ser Lys Cys 
                405                 410                 415     


Asp Tyr Tyr Glu Glu Gly Gln Arg Glu Lys Gln Glu Lys Phe Ile Cys 
            420                 425                 430         


Lys Ser Cys Ala Phe Glu Val Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
        435                 440                 445             


Ile Ala Lys Ser Ala Arg Tyr Ile Ser Asp Ser Thr Glu Arg Glu Tyr 
    450                 455                 460                 


His Lys Lys Lys Gln Glu Asp Leu Lys Glu Ile Leu Gly Glu Asn Asp 
465                 470                 475                 480 


Ile Ile Asn Glu Gln Leu Ser Leu Phe Asp Asn His Asp Asp Ile Ala 
                485                 490                 495     


<210>  368
<211>  497
<212>  PRT
<213>  Clostridium sp.

<400>  368

Met Ile Thr Val Arg Lys Ile Lys Leu Thr Ile Met Gly Asp Lys Asp 
1               5                   10                  15      


Thr Arg Asn Ser Gln Tyr Lys Trp Ile Arg Asp Glu Gln Tyr Asn Gln 
            20                  25                  30          


Tyr Arg Ala Leu Asn Met Gly Met Thr Tyr Leu Ala Val Asn Asp Ile 
        35                  40                  45              


Leu Tyr Met Asn Glu Ser Gly Leu Glu Ile Arg Thr Ile Lys Asp Leu 
    50                  55                  60                  


Lys Asp Cys Glu Lys Asp Ile Asp Lys Asn Lys Lys Glu Ile Glu Lys 
65                  70                  75                  80  


Leu Thr Ala Arg Leu Glu Lys Glu Gln Asn Lys Lys Asn Ser Ser Ser 
                85                  90                  95      


Glu Lys Leu Asp Glu Ile Lys Tyr Lys Ile Ser Leu Val Glu Asn Lys 
            100                 105                 110         


Ile Glu Asp Tyr Lys Leu Lys Ile Val Glu Leu Asn Lys Ile Ile Glu 
        115                 120                 125             


Glu Thr Gln Lys Glu Arg Met Asp Ile Gln Lys Glu Phe Lys Glu Lys 
    130                 135                 140                 


Tyr Val Asp Asp Leu Tyr Gln Val Leu Asp Lys Ile Pro Phe Lys His 
145                 150                 155                 160 


Leu Asp Asn Lys Ser Leu Val Thr Gln Arg Ile Lys Ala Asp Ile Lys 
                165                 170                 175     


Ser Asp Lys Ser Asn Gly Leu Leu Lys Gly Glu Arg Ser Ile Arg Asn 
            180                 185                 190         


Tyr Lys Arg Asn Phe Pro Leu Met Thr Arg Gly Arg Asp Leu Lys Phe 
        195                 200                 205             


Lys Tyr Asp Asp Asn Asp Asp Ile Glu Ile Lys Trp Met Glu Gly Ile 
    210                 215                 220                 


Lys Phe Lys Val Ile Leu Gly Asn Arg Ile Lys Asn Ser Leu Glu Leu 
225                 230                 235                 240 


Arg His Thr Leu His Lys Val Ile Glu Gly Lys Tyr Lys Ile Cys Asp 
                245                 250                 255     


Ser Ser Leu Gln Phe Asp Lys Asn Asn Asn Leu Ile Leu Asn Leu Thr 
            260                 265                 270         


Leu Asp Ile Pro Ile Asp Ile Val Asn Lys Lys Val Ser Gly Arg Val 
        275                 280                 285             


Val Gly Val Asp Leu Gly Leu Lys Ile Pro Ala Tyr Cys Ala Leu Asn 
    290                 295                 300                 


Asp Val Glu Tyr Ile Lys Lys Ser Ile Gly Arg Ile Asp Asp Phe Leu 
305                 310                 315                 320 


Lys Val Arg Thr Gln Met Gln Ser Arg Arg Arg Arg Leu Gln Ile Ala 
                325                 330                 335     


Ile Gln Ser Ala Lys Gly Gly Lys Gly Arg Val Asn Lys Leu Gln Ala 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Lys Glu Lys Asn Phe Ala Lys Thr Tyr Asn 
        355                 360                 365             


His Phe Leu Ser Ser Asn Ile Val Lys Phe Ala Val Ser Asn Gln Ala 
    370                 375                 380                 


Glu Gln Ile Asn Met Glu Leu Leu Ser Leu Lys Glu Thr Gln Asn Lys 
385                 390                 395                 400 


Ser Ile Leu Arg Asn Trp Ser Tyr Tyr Gln Leu Gln Thr Met Ile Glu 
                405                 410                 415     


Tyr Lys Ala Gln Arg Glu Gly Ile Lys Val Lys Tyr Ile Asp Pro Tyr 
            420                 425                 430         


His Thr Ser Gln Thr Cys Ser Lys Cys Gly Asn Tyr Glu Glu Gly Gln 
        435                 440                 445             


Arg Glu Ser Gln Ala Asp Phe Ile Cys Lys Lys Cys Gly Tyr Lys Val 
    450                 455                 460                 


Asn Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Met Ser Asn Lys Tyr 
465                 470                 475                 480 


Ile Thr Lys Lys Glu Glu Ser Lys Tyr Tyr Lys Ile Lys Glu Ser Met 
                485                 490                 495     


Val 
    


<210>  369
<211>  497
<212>  PRT
<213>  Bacteroides plebeius

<400>  369

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Lys Ile Val Lys Asp Arg 
1               5                   10                  15      


Leu Thr Asp Glu Lys Glu Arg Leu Thr Asp Glu Glu Tyr Asp Gln Gln 
            20                  25                  30          


Trp Lys Tyr Leu Tyr Gln Ile Asn Asn Thr Ile Tyr Gln Ala Ala Asn 
        35                  40                  45              


Arg Ile Ser Thr His Cys Leu Phe Asn Asp Glu Tyr Glu Met Arg Leu 
    50                  55                  60                  


Arg Leu Ser Tyr Lys Ser Arg Tyr Asp Lys Ile Asn Lys Gly Leu Glu 
65                  70                  75                  80  


Asn Ile Lys Thr Glu Leu Glu Lys Leu Asn Thr Lys Lys Lys Thr Ser 
                85                  90                  95      


Asp Lys Glu Lys Arg Asp Arg Leu Ile Asn Glu Gln Arg Gln Leu Val 
            100                 105                 110         


Asp Glu Arg Asn Glu Leu Asp Glu Asp Val Lys Asn Lys Lys Lys Asp 
        115                 120                 125             


Phe Phe Gln Cys Ser Lys Gln Asn Ser Thr Tyr Gln Leu Ala Ser Lys 
    130                 135                 140                 


Glu Phe Leu Lys Tyr Ile Pro Ala Glu Ile Leu Thr Asp Leu Asn Arg 
145                 150                 155                 160 


Tyr Val Gln Asn Asn His Asn Asn Asn Lys Lys Lys Val Lys Ser Gly 
                165                 170                 175     


Glu Arg Ala Leu Ser Thr Tyr Lys Lys Gly Met Gly Ile Pro Phe Ser 
            180                 185                 190         


Ile Lys Pro Gln Ser Gly Leu Arg Leu Phe Val Lys Glu Glu Gly Ile 
        195                 200                 205             


Tyr Leu Lys Trp Phe Lys Gly Ile Leu Phe Arg Leu Glu Phe Gly Lys 
    210                 215                 220                 


Asp Thr Ser Asn Asn Arg Cys Ile Val Glu Arg Leu Ile Glu Ser Asp 
225                 230                 235                 240 


Lys Gln Gln Lys Lys Asn Lys Gly Glu Asp Tyr Val Ala Asn Asn Ser 
                245                 250                 255     


Ser Ile Lys Leu Ile Lys Lys Gly Asn Asp Lys Ser Thr Arg Ile Phe 
            260                 265                 270         


Leu Leu Leu Ser Ile Asp Ile Pro Ala Lys Lys Gln Val Leu Asp Lys 
        275                 280                 285             


Glu Val Val Leu Gly Val Asp Leu Gly Ile Lys Cys Pro Leu Tyr Leu 
    290                 295                 300                 


Ala Ile Asn Lys Asn Asp Asn Phe Lys Met Gln Ile Gly Asp Ile Glu 
305                 310                 315                 320 


His Phe His Asn Gln Arg Thr Met Phe Gln Lys Arg Phe Lys Ser Leu 
                325                 330                 335     


Gln Lys Leu Met Cys Thr Gln Gly Gly His Gly Arg Lys Lys Lys Leu 
            340                 345                 350         


Glu Pro Leu Glu Lys Leu Lys Glu Lys Glu Arg Asn Trp Val His Thr 
        355                 360                 365             


Gln Asn His Val Tyr Ser Arg Glu Val Ile Lys Gln Ala Leu Lys His 
    370                 375                 380                 


Asn Ala Gly Thr Ile His Met Glu Ser Leu Lys Asp Phe Gly Lys Gly 
385                 390                 395                 400 


Lys Glu Gly Tyr Val Lys Asp Glu Tyr Lys Tyr Leu Leu Arg Tyr Trp 
                405                 410                 415     


Ser Tyr Tyr Glu Leu Gln Ser Met Ile Glu Tyr Lys Ala Lys Leu Glu 
            420                 425                 430         


Gly Ile Glu Val Lys Tyr Ile Asp Pro Ala Tyr Thr Ser Gln Thr Cys 
        435                 440                 445             


Ser Tyr Cys Gly Glu Arg Gly Glu Arg Lys Lys Gln Glu Glu Phe Val 
    450                 455                 460                 


Cys Thr Asn Pro Gln Cys Lys Arg Arg Gly Glu Lys Ile Asn Ala Asp 
465                 470                 475                 480 


Phe Asn Ala Ala Arg Asn Ile Ala Met Ser Lys Lys Ile Val Lys Asp 
                485                 490                 495     


Asn 
    


<210>  370
<211>  536
<212>  PRT
<213>  Dorea longicatena

<400>  370

Met Ser Asp Glu Ile Thr Ile Thr Arg Lys Tyr Val Ile Tyr Pro Ile 
1               5                   10                  15      


Ala Ser Asp Met Lys Glu Trp Glu Arg Lys Val Ile Lys Tyr Val Ser 
            20                  25                  30          


Glu Asn Tyr Glu Lys Arg Ile Gln Leu Leu Glu Gln Lys Ile Lys His 
        35                  40                  45              


Ser Lys Ile Pro Lys Glu Glu Lys Glu Asn Leu Arg Lys Glu Leu Asp 
    50                  55                  60                  


Asn Leu Lys Ile Lys Tyr Asp Ala Phe Gln Ala Asp Pro Ala Ile Thr 
65                  70                  75                  80  


Gln Ser Glu Ile Asn Thr Tyr Thr Tyr Gly Thr Val Arg Thr Ala Met 
                85                  90                  95      


Glu Glu Glu Ala Arg Lys Lys Asn Tyr Ile Leu Ser Trp Ile Tyr Ser 
            100                 105                 110         


Glu Met Ile Gly Ala Gly Val Gln His Met Glu Thr Leu Lys Glu Lys 
        115                 120                 125             


Tyr Gln Phe Ile Ser Asn Arg Met Asn Tyr Ala Tyr Arg Leu Pro Gly 
    130                 135                 140                 


Asn Lys Asn Gly Ser Leu Phe Asp Glu Ala Glu Ile His Asn Ile Leu 
145                 150                 155                 160 


Lys Gly Tyr Gly Phe Ala Phe Ser Gln Met Leu Thr Ser Lys Ile Lys 
                165                 170                 175     


Asp Cys Val Lys Lys Gly Leu Leu Glu Gly Lys Val Ser Leu Pro Asn 
            180                 185                 190         


Tyr Lys Ile Asp Ser Pro Phe Thr Val Ala Lys Ala Cys Met Gly Phe 
        195                 200                 205             


Ser His Asp Tyr Asp Asn Phe Glu Glu Leu Cys Glu His Ile His Asp 
    210                 215                 220                 


Ser Asp Leu Lys Leu Tyr Phe Asp Tyr Gly Gly Asn Lys Arg Pro Ser 
225                 230                 235                 240 


Ile Ala Lys Phe Lys Ile Asp Leu Gly Lys Gly Lys Asn Arg Glu Glu 
                245                 250                 255     


Leu Ala Ala Thr Leu Leu Lys Val Tyr Ser Gly Glu Tyr Glu Tyr Cys 
            260                 265                 270         


Gly Ser Ser Ile Gln Ile Ser Lys Lys Lys Ile Ile Leu Asn Leu Ser 
        275                 280                 285             


Met Lys Ile Pro Lys Ile Pro Thr Glu Leu Asp Glu Asn Thr Val Val 
    290                 295                 300                 


Gly Val Asn Leu Gly Val Ala Ile Pro Ala Thr Cys Ala Leu Asn Asn 
305                 310                 315                 320 


Asp Leu His Lys Lys Leu Tyr Ile Gly Thr Tyr Glu Glu Phe Ala His 
                325                 330                 335     


Gln Lys Val Lys Leu Gln Glu Gln Arg Lys Arg Leu Gln Ile Ser Leu 
            340                 345                 350         


Arg Asn Thr Ser Gly Gly His Gly Arg Lys Lys Lys Leu Gln Ala Leu 
        355                 360                 365             


Glu Arg Leu Lys Ala Arg Glu Lys Gln Tyr Thr Glu Thr Val Cys His 
    370                 375                 380                 


Lys Ile Ser Lys Arg Ile Val Asp Phe Ala Leu Lys Asn His Ala Lys 
385                 390                 395                 400 


Tyr Ile Asn Leu Glu Asn Leu Gln Gly Tyr Asp Thr Asn Glu Phe Ile 
                405                 410                 415     


Leu Arg Asn Trp Cys Tyr Tyr Arg Leu Gln Gln Tyr Thr Glu Tyr Lys 
            420                 425                 430         


Ala Ala Arg Tyr Gly Ile Ile Val Arg Lys Val Asn Pro Cys Tyr Asn 
        435                 440                 445             


Ala Gln Ile Cys Ser Ile Cys Gly Gly Trp Asp Lys Asp Gln Arg Leu 
    450                 455                 460                 


Ser Arg Ala Asp Phe Ile Cys Lys Asp Pro Asn Cys Ile Ser His Lys 
465                 470                 475                 480 


Lys Tyr Lys His Pro Gln Cys Ala Glu Phe Asn Asn Ala Arg Asn Val 
                485                 490                 495     


Ala Met Ser Glu Leu Phe Met Glu Ser Gly Lys Val Thr Gly Lys Asp 
            500                 505                 510         


Phe Glu Arg Ala Arg Ala Tyr Tyr Ser Lys Lys Asn Pro Gly Ile Ile 
        515                 520                 525             


Trp Glu Phe Val Glu Ser Lys Glu 
    530                 535     


<210>  371
<211>  543
<212>  PRT
<213>  Sulfurihydrogenibium azorense

<400>  371

Met Val Asn Lys Asn Leu Lys Ile Thr Ser Gly Arg Asp Asn Val Glu 
1               5                   10                  15      


Phe Tyr Leu Ile Val Asp Gly Glu Glu Ile Pro Leu Lys Lys Gln Asp 
            20                  25                  30          


Ile Arg Asn Leu Ile Thr Glu Phe Leu Lys Asp Val Arg Leu Ala Tyr 
        35                  40                  45              


Ile Lys Phe Leu Pro Asn Ile Glu Leu Ile Gln Thr Gly Lys Tyr Phe 
    50                  55                  60                  


Thr Val Asn Ile Asn Ser Lys Arg Leu Thr Asn Glu Asn Leu Ser Asn 
65                  70                  75                  80  


Ser Leu Thr Lys Leu Ile Pro Lys Asn Tyr Ile Glu Leu Glu Ile Asn 
                85                  90                  95      


Gly Ser Lys Val Lys Leu Asp Tyr Lys Lys Asp Tyr Val Ala Thr Ser 
            100                 105                 110         


Ile Leu Tyr Ser Val Ala Lys Asp Ile Thr Gly Asn Leu Lys Glu Gly 
        115                 120                 125             


Lys Thr Val Val Ile Lys Asn Leu Gln Tyr Leu Ala Arg Ile Lys Pro 
    130                 135                 140                 


Asp Lys Asn Thr Pro Tyr Asp Lys Ala Phe Ser Gln Val Ile Lys Glu 
145                 150                 155                 160 


Phe Glu Ile Val Glu Asn Gly Lys Thr Val Glu Cys Val Ile Thr Phe 
                165                 170                 175     


Ser Ala Phe Lys Asn Ala Ser Ile Lys Val Lys Phe Lys Met Asn Leu 
            180                 185                 190         


Arg Lys Lys Asn Phe Ala Val Asn Asn Ser Tyr Tyr Gln Ile Leu Asn 
        195                 200                 205             


Arg Ile Lys Asn Gln Glu Tyr Lys Val Ala Tyr Ile Gly Ile Gly Tyr 
    210                 215                 220                 


Arg Glu Lys Lys Gly Ala Phe Leu Leu Ile Ser Tyr Lys Phe Glu Lys 
225                 230                 235                 240 


Gln Pro Glu Thr Ser Gln Glu Gln Glu Lys Val Met Gly Val Asp Leu 
                245                 250                 255     


Gly Gln Val Tyr Leu Ile Tyr Tyr Ser Ile Thr Asn Ser His Ser Arg 
            260                 265                 270         


Gly Asp Ile Ser Leu Ser Tyr Ser Trp Lys Asp Lys Ile Ile Gly Ile 
        275                 280                 285             


Trp Asn Arg Lys Lys His Leu Gln Lys Ser Leu Met Glu Ile Arg Asn 
    290                 295                 300                 


Leu Lys Lys Gln Gly Ile Asn Asp Glu Ser Ile Glu Lys Arg Tyr Glu 
305                 310                 315                 320 


Lys Ile Val Lys Glu Leu Asn Ser Val Arg Glu Tyr Glu Lys Asn Phe 
                325                 330                 335     


Met Glu Thr Leu Asn Lys Gln Ile Ala Thr Lys Leu Ile Asp Ile Ala 
            340                 345                 350         


Val Lys Glu Lys Val Lys Thr Ile Val Leu Glu Asp Leu Ser Leu Ser 
        355                 360                 365             


Asn Glu Glu Lys Asn Ser Leu Ala Phe Pro Lys Trp Asn Tyr Tyr Gln 
    370                 375                 380                 


Leu Gln Ser Phe Ile Glu Asn Lys Ala Gln Glu Asn Gly Ile Gln Val 
385                 390                 395                 400 


Lys Lys Ile Asn Pro Ala Tyr Thr Ser Gln Arg Cys Pro Ser Cys Gly 
                405                 410                 415     


Phe Ile Ala Phe Tyr Lys Glu Met Val Arg Pro Lys Arg Glu Lys Phe 
            420                 425                 430         


Thr Cys Pro Val Cys Gly Phe Ser Ser Asn Ala Asp Tyr Val Ala Ser 
        435                 440                 445             


Leu Asn Ile Ala Glu Glu Asn Ile Glu Glu Lys Ile Lys Ala Arg Leu 
    450                 455                 460                 


Ile Ser Asp Ile Glu Lys Ile Glu Lys Val Asp Lys Asn Asn Lys Val 
465                 470                 475                 480 


Phe Thr Leu Phe Ala Ile Arg Asn Arg Ile Val Lys Asp Leu Leu Lys 
                485                 490                 495     


Glu Phe Phe Asn Thr Asn Asn Gly Ser Ser Lys Lys Leu Leu Lys Arg 
            500                 505                 510         


Leu Glu Ile Ser Asn Lys Glu Ala Tyr Asn Thr Leu Ile Arg Asp Leu 
        515                 520                 525             


Lys Gln Phe Lys Val Glu Tyr Leu Asp Lys Arg Ile Ser Asn Val 
    530                 535                 540             


