                               SEQUENCE LISTING

<110> THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF 
      MILITARY MEDICINE, INC.
      CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> GENOMIC REARRANGEMENTS ASSOCIATED WITH PROSTATE CANCER AND 
      METHODS OF USING THE SAME

<130> HMJ-163-PCT

<140>
<141>

<150> 62/779,035
<151> 2018-12-13

<160> 25    

<170> PatentIn version 3.5

<210> 1
<211> 338
<212> PRT
<213> Homo sapiens

<400> 1
Met Val Arg Arg Val Gln Pro Asp Arg Lys Gln Leu Pro Leu Val Leu 
1               5                   10                  15      


Leu Arg Leu Leu Cys Leu Leu Pro Thr Gly Leu Pro Val Arg Ser Val 
            20                  25                  30          


Asp Phe Asn Arg Gly Thr Asp Asn Ile Thr Val Arg Gln Gly Asp Thr 
        35                  40                  45              


Ala Ile Leu Arg Cys Val Val Glu Asp Lys Asn Ser Lys Val Ala Trp 
    50                  55                  60                  


Leu Asn Arg Ser Gly Ile Ile Phe Ala Gly His Asp Lys Trp Ser Leu 
65                  70                  75                  80  


Asp Pro Arg Val Glu Leu Glu Lys Arg His Ser Leu Glu Tyr Ser Leu 
                85                  90                  95      


Arg Ile Gln Lys Val Asp Val Tyr Asp Glu Gly Ser Tyr Thr Cys Ser 
            100                 105                 110         


Val Gln Thr Gln His Glu Pro Lys Thr Ser Gln Val Tyr Leu Ile Val 
        115                 120                 125             


Gln Val Pro Pro Lys Ile Ser Asn Ile Ser Ser Asp Val Thr Val Asn 
    130                 135                 140                 


Glu Gly Ser Asn Val Thr Leu Val Cys Met Ala Asn Gly Arg Pro Glu 
145                 150                 155                 160 


Pro Val Ile Thr Trp Arg His Leu Thr Pro Thr Gly Arg Glu Phe Glu 
                165                 170                 175     


Gly Glu Glu Glu Tyr Leu Glu Ile Leu Gly Ile Thr Arg Glu Gln Ser 
            180                 185                 190         


Gly Lys Tyr Glu Cys Lys Ala Ala Asn Glu Val Ser Ser Ala Asp Val 
        195                 200                 205             


Lys Gln Val Lys Val Thr Val Asn Tyr Pro Pro Thr Ile Thr Glu Ser 
    210                 215                 220                 


Lys Ser Asn Glu Ala Thr Thr Gly Arg Gln Ala Ser Leu Lys Cys Glu 
225                 230                 235                 240 


Ala Ser Ala Val Pro Ala Pro Asp Phe Glu Trp Tyr Arg Asp Asp Thr 
                245                 250                 255     


Arg Ile Asn Ser Ala Asn Gly Leu Glu Ile Lys Ser Thr Glu Gly Gln 
            260                 265                 270         


Ser Ser Leu Thr Val Thr Asn Val Thr Glu Glu His Tyr Gly Asn Tyr 
        275                 280                 285             


Thr Cys Val Ala Ala Asn Lys Leu Gly Val Thr Asn Ala Ser Leu Val 
    290                 295                 300                 


Leu Phe Arg Pro Gly Ser Val Arg Gly Ile Asn Gly Ser Ile Ser Leu 
305                 310                 315                 320 


Ala Val Pro Leu Trp Leu Leu Ala Ala Ser Leu Leu Cys Leu Leu Ser 
                325                 330                 335     


Lys Cys 
        


<210> 2
<211> 9478
<212> DNA
<213> Homo sapiens

<400> 2
ggaggagggg gagagaggct ctgggttgct gctgcttctg ctgctgctgc tgctgtgtgg       60

ctgtttctgt acactcactg gcaggcttgg tgccggctcc ctcgcccgcc cgcccgccag      120

cctgggaaag tgggttacag agcgaaggag ctcagctcag acactggcag aggagcatcc      180

agtcacagag agaccaaaca agaacccttt cctttggctt cctcttcagc tcttccagag      240

ggcttgctat ttgcactctc tcttttgaaa ttgtgttgct tttacttttc acccttctgc      300

ttgggtttta tgagggcttt gttaagtctt agagggaaaa gagactgagc gagggaaaga      360

gagaggcaaa gtggaaagga ccataaactg gcaaagcccg ctctgcgctc gctgtggatg      420

aaagccccgt gttggtgaag cctctcctcg cgagcagcgc gcacccctcc agagcacccc      480

gcggacccgc acctcggcgt ggccaccatg gtcaggagag ttcagccgga tcggaaacag      540

ttgccactgg tcctactgag attgctctgc cttcttccca caggactgcc tgttcgcagc      600

gtggatttta accgaggcac ggacaacatc accgtgaggc agggggacac agccatcctc      660

aggtgcgttg tagaagacaa gaactcaaag gtggcctggt tgaaccgttc tggcatcatt      720

tttgctggac atgacaagtg gtctctggac ccacgggttg agctggagaa acgccattct      780

ctggaataca gcctccgaat ccagaaggtg gatgtctatg atgagggttc ctacacttgc      840

tcagttcaga cacagcatga gcccaagacc tcccaagttt acttgatcgt acaagtccca      900

ccaaagatct ccaatatctc ctcggatgtc actgtgaatg agggcagcaa cgtgactctg      960

gtctgcatgg ccaatggccg tcctgaacct gttatcacct ggagacacct tacaccaact     1020

ggaagggaat ttgaaggaga agaagaatat ctggagatcc ttggcatcac cagggagcag     1080

tcaggcaaat atgagtgcaa agctgccaac gaggtctcct cggcggatgt caaacaagtc     1140

aaggtcactg tgaactatcc tcccactatc acagaatcca agagcaatga agccaccaca     1200

ggacgacaag cttcactcaa atgtgaggcc tcggcagtgc ctgcacctga ctttgagtgg     1260

taccgggatg acactaggat aaatagtgcc aatggccttg agattaagag cacggagggc     1320

cagtcttccc tgacggtgac caacgtcact gaggagcact acggcaacta cacctgtgtg     1380

gctgccaaca agctgggggt caccaatgcc agcctagtcc ttttcagacc tgggtcggtg     1440

agaggaataa atggatccat cagtctggcc gtaccactgt ggctgctggc agcatctctg     1500

ctctgccttc tcagcaaatg ttaatagaat aaaaatttaa aaataattta aaaaacacac     1560

aaaaatgcgt cacacagaat acagagagag agagacagag agagagagag agagagagat     1620

gggggagacc gtttatttca caactttgtg tgtttataca tgaaggggga aataagaaag     1680

tgaagaagaa aatacaacat ttaaaacaat tttacagtcc atcattaaaa atttatgtat     1740

cattcaggat ggagaaggtt ctactgggat atgtttatat ctactaagca aatgtatgct     1800

gtgtaaagac tacaccacac taaggacatc tggatgctgt aaaaataaga gaagaaccag     1860

atggatatta agccccccaa cacacacttt atccttcctt ccttcatctt ttttcatctg     1920

tggggaagaa aataaggtct tgcctttggt gtttatattt ccataacctt ttaattctat     1980

ttttcatttg agctgacttg tagccacttc agactatcaa tggaatctta tgttgagcct     2040

ttctctggct ttccttcctc cactatctct ccaactttag agatcatccc ctctccctcc     2100

agtgcgttct atctccccca cacccaccct agatactccc ttttcaccca cctttcctcc     2160

ctcacctctc ctcacctcca ccccctcccc agagcactag tcatgccgca aatgctagga     2220

agtgccattt tcattttctc cactgtgcgt gtgtgctcaa gtctttcgct ctcacgtggg     2280

tgtacatgtg tgtgagcgtg tgtgtgtctc tctctaaagc atgccaaggg aatggtccat     2340

gtgtacatag actcattgtg ctgtagatac tgtcctgcat tgtaattgtg agatgcggct     2400

gtaacaagtt gctgggggag atggcgggga aagaggcaag gagcagagtc ctccctacat     2460

ccatggctgt cacatggcat cagtgtgtat tcaaaccaag ctatgctcct tccaagggca     2520

ggaccccata ttcctcctag tcccatcatc agaaccgagt ggggagtcac tcagaatatc     2580

actgtaaatg aaagtgccta ctatcgatgg ggtaagcaaa cagcataagg aattatgacg     2640

tggacgaggt gacctaggag agaaaatttc agattttact ctcatttcat gagtctgagg     2700

gattcttata tttcctggca tttaacaggg taggccctgc tccactgtga aaatgagcag     2760

catgtgttga gtaaatcccc agaaacagga aggtctccaa gtgtcaactc ccagtgaaag     2820

aatgatgaac cacttggaga tcctaagcag ccctgtttta cctcctccct aatcttaaat     2880

aacatttgtc ccatgaattc ccctgagcag agattgtttc ctatttcaga taaaatacag     2940

tgaaagtgag caaggcagaa aaagtcaaca gatgcccagg ctcctactgt attctggaga     3000

tactgtcaga gctctaatac agagcactgg ccataatgaa aagcagttca ctccttgtgc     3060

tcctctgcag atgtttttcc cagtgttcta ggttaatgtt ttatttggtt gcctgcataa     3120

tccctgttct gtttcactga tggtgtttgc agcaccactg ttcatggtgg tccactgtta     3180

tcctatgcca gggtgctaag aattgcatga tattcatctt ccctgctcta tttaaattta     3240

catctataag agtcatcttg acattaacac tgaaatgtga tctaggtcct taaccaaaat     3300

tgctgggcaa cttgtaataa atttagacag aaattttatg agtaccacaa agcttggtgt     3360

taccacatca ccagaaggat ttcttaggaa atgtcttgcc gagagagctg gctctctgca     3420

tatagatgtc tttgtcagaa aaccaaccct tgctctcact tacacagtag taagcactga     3480

aagtggttca gttcatgaga ggacagagaa ttattttgag attatatttg aatgtaatct     3540

tgcagagcca aatatggtat gtcattaagt tggaaccttg taaatagctg ttccatgtta     3600

taaaatgaga aactttgtaa ctggaaaaaa agaaaggaaa gaaggaagga aggaaggaag     3660

gaaggcaggg agggggggac ggggaagggg gggagggagg gagggaggga gggagggagg     3720

gagggaggga ggaaggaagg aaggaaggaa ggaaggagaa aggaaaggaa ggcaggaggg     3780

agaaagatct aagtagcatt gttaatttct tcaatttctt ctaagggatt ttattgtttg     3840

ttttagaagc ttatcacagc cttctttcat gattttgcag tttagacttg atacaaggaa     3900

aaattcagct tggggatggt taagagtgtt tatagcagat tctgacatag gagagaaaac     3960

aaattctcat ccaagaaggt agctagtaaa atatagggaa ggtgagccat attcctatgc     4020

agcatcaatt tattgacaat caggtatttc tcttaacagt ttggtcttct tagttcaaga     4080

ataaagggta tcatctttaa taataagcat tccccaaaaa ttgaagaggc agtcacacac     4140

ttaagtgtgt ggctttagaa aagcgcatgc taatttaaag atatacagga agagaaaagt     4200

aggagttaag ttggatgttg ttagaagttg gatgttagta ttaccttcag gaacagatcc     4260

ccatggcatg tcacaggcct taattatata cctggctttc ttattgtctc cactttatca     4320

tgaggacaag gtcttggttt catgggagga acttctccat tgaaataaat gtctgccatg     4380

tcagcaccgt ttgttccctc agttttaata taatggacca tatattaaac ataattaaac     4440

atatatttaa atgtggtgtt tgcctgtgtc tctagcagga tcttgaaatt ttaaaaattt     4500

gcttctggtt cctgtttcag agaaaacatt gtccccagaa atttcatagg attgaaagtg     4560

ttccctaagc agtgtgaaca atggaggaaa atatagttta gagaaaagtc agggaaaggt     4620

agggccagag gactgacacc aagaaatcat tgaatctcaa cataagactt cttggaattt     4680

agttaatcat attggaataa attccttcaa gaatcttgtc ccttggtaat caaagtttga     4740

aaccccgcac tgaaaagcac caactggttg gaaataatat actgagagga gtgaaattca     4800

tcaattaatc tgagtggcta atatatttaa tatcctttgt atacaaagta aaactccacc     4860

attcgtaaaa ggaaatcctt agacccaact ttcagttaac aaaaacagaa atgactttga     4920

cccagggtgc ttcctgaaga atgagaacta tccagggctt tacaactgca gaattgtaat     4980

tatgctctgt gcaattgttg agcaaaggtt ttgccttgct ggataaaaag tcttgtttgt     5040

ttcgagacat gaaatcccca tgtcttaaaa gaactaaggc ttatagaaaa gcagatgggt     5100

tttctctcag gaaggactgc cccattgacc tttgccttct cttccaagtc agacagactt     5160

ctcgcttgcc atgggcattt ttttactaca tagtcagact actggggcta cttatagaga     5220

ccttgtaaaa gtactcgtga ttttcacgtt cttggaggac caaacaaaaa tctgtttctc     5280

ctccaaaaat ggacttacct cctttgcaca caaaagctaa actcctcagc atgaaattgt     5340

ttgagttatt actttaccaa gttgtgagct tcttgaatcc tccagagtcg cagattccat     5400

ccctgagttg gttgtggttt cactgtttct attggctatt ctccctgaat ttttcatttt     5460

gttctttgca gggctcgaat tatttgtgga aaacaataat atatatgtgt gtgtattttt     5520

tatctttata gatgctatat ttacaataat gtatgtatta taagacaaat taagaataat     5580

gttttgatct taaaaggaag aaaagtactg aatttggttg tttagaaaga aaatctatgc     5640

tcacgtagaa agacatagag ccccactttt tccgttttgt aattatttgg cgaaaagaaa     5700

tttgcttata gactatgttt aatgggatta accatgtcct catttttctt ttcatcctca     5760

tacactttta gcctgcattt agtcttggtt accaatatca ttttttaaga gaaatgtaag     5820

tacagtgcta tatcttacct acataaacta ttaatatttt gaagacaaat gtgaaacaca     5880

ccacaaaaat ggtgagataa gaaacaaaaa tgcagtttag gaagcctcct ccttgcttaa     5940

atgtttagaa tatttcttct ccaaagactg catttgcctc agtgatgtaa attttccatc     6000

atggttggca taatatctgt aaacatctca ctaaatgcaa aatggagttt acatttatgt     6060

gcatactagc agaaaagaag taaactattc tcatttgcat gtagctatgc tgttcaaatg     6120

tcgccaacca aaatttagga aagaatttgt tttcacccag catgtacatc tcacttttct     6180

cttggcaagg aagctggtgt taacgttggg tttaggttta acatttacac cagcgaaaat     6240

gtttatgaat attatggaaa acttatttta aaccttgatt tcttttgagc acatttacat     6300

gctgcgtgct gattaataaa ttaggcacca atcatgtgta aatcaatgta aatcactagt     6360

ttatgtacat aatataaact atgtaaactt catttttcat gcagtgccca actactgcta     6420

aggtttacta tgattcttaa ggaaaaaaaa atcaaataaa aataaataaa aactgaaacg     6480

tttcacagtt cagaatcgga agaattacga ctaaagctcc aaatatgagg ttgccttagc     6540

caaaggaagc agacccacag gaacagttca aggtttatat cctgctcaag tcacctcttt     6600

ggtctttcag gatctaagtg gagattgtcc caactgttgc tgtagttgtc tcacccgacc     6660

ccaaagcaag ggaaatagag ggaaaggttt taagggctat atgtctgctg tatccactcc     6720

cagctatctt ctttttactc ctttctcacc atctaagatg tcttatttaa atagctccaa     6780

ggaagtgacc taaaccttga tgagcaaaat attactcagt ttttattttc cattcaacaa     6840

aagcagtggg aaagcttgcc atctggattc taagaaattg tgcaatataa aaaatgttat     6900

atcctcgaga aatatcttgc tgagtcaccc taggaaataa ctacctttta tttatctggt     6960

agcctaatgt ttccacacat ttatcctgaa tattgcaagt gagggactga atcattttta     7020

attgggagtt atctttctca ggcatgttct cttggagtct ttttgaagtg cctgacacgt     7080

gtaacaggat gacatatata tcattcctac aatatgaaca actgttacat aaaaaattat     7140

caaggagatg atttcaggaa acaagtgaac tttctgcaaa gacttataaa aattttaggt     7200

caaattaact tcaggcttta aatgcactaa tctacctaag agaaaaaaaa agaaaaaaaa     7260

caggaaggag ttttaagggc tcatgtgcct gttgtatcaa cccccaagtg tcttcttggt     7320

actgcttcct catcatctaa gataaactga caactttaaa gtgaggtaga aggtgtattg     7380

aattgggagt caggagaatt gggttctaac cccaagttca gccacaaata aagctgtgag     7440

acattggcaa gtcatttaac tttcctgagt cttggttttc tcatcctgaa agtgagggat     7500

tcggctgacg tctctaaaat ctctttcaac tctaaccttt attctgaata agaatttaat     7560

attcacttag tgctgtgccc agcactgttt gtaaacagca gctgtttgtt atctctagtt     7620

tggtctctgt attctcatca cttctcagaa ctatcattct accgtcttca tttctaaacc     7680

caaaactgct agaatacagg gactctggac tgggtctgta aattttttct gatcaaaact     7740

ttatagcagt gtagagaagg gacacattca aattacacta aggacattga catagctggg     7800

gttgtttcct tgtttatatt ataaaaccta aatgtggaac tatattctaa taatctttca     7860

taggaaggaa aatagccaga ctgggtatta tgcatgtaac aaatgaggac attgtgcata     7920

agaaaggaaa cattagtttt ctgtcatcct gggccaagta cctcattaca gtaaatgtgt     7980

gtctttggaa actctttgct tgtgctgatg gcggtaagca tggggtccca ggcaggttca     8040

aaggctgaac tgtaagaaat gggcaagaca atacattttg ttttggaagg aatttctcat     8100

gggataagtt tcccaaagct tgaattatag gctatgaaat aaagcaaata gatggagaga     8160

aaacaagtat tgttttcaaa aagtacaagt caattctatt taaagaagac aagctgaaaa     8220

taaaacaaaa ataaacacaa tttaggaggt tacagagttg aagacagtat gaattgttgt     8280

gaaggccaaa atcaaatgtg aaagttaggt tctctgagaa aagggtaagc agaaaggatg     8340

atttctcaag caattaataa ggaattattt tcttgtgcca tgttctagat gcattgagca     8400

cagatcctct tgtcctaagc tgtcctagag gctcaggtta gcatctatcc aaagttgtcc     8460

tttgatttta ttgtctgaaa gaacagaagg catcagagtt tccagtcact gaagagtagg     8520

gtttgttcat cacttcccag caatcacatc actttgtgta ggtaaggata tatgatgtgc     8580

ttagattact tatgaagctc tctctaagtg ggagaatgac ctgtccatgg gacaactccc     8640

cgttttcatg gtcatttcag aagtacctct ttttgggcag tgctcctgga tctacttcta     8700

cagccacatt ctactctgca caatcctccc tatgtaaagc caggcacagt acaaatatgc     8760

ttcttgcaag tgaagaaaac ccatggaagt cctagcttca tggcacgctg cagcaatccc     8820

aagctaccag gagcctcttt tgaacccact tccctaagtc tttgctcttc accagagaat     8880

ggaaattgtt catcctggtg aactgtggcc aagttctgct ccctaagtat ttacttggag     8940

tagggaggtt aaagggaaga aattcagggg gagagaagca aaagagaaca cttccaactc     9000

cctcccccat ctcccaatgc tccccacctt ccttatcact gctctactga agggtgtata     9060

aatcctgctc ttggttagaa ttctccttat taacagtgtt atatacatat aaatatatat     9120

ataaatatat tccttttttc agccctgtag acatgaactg atcttccctt gaagatacaa     9180

acacatggcc attttttgtt tgggattttt tgtttttcaa ggtttttcat ttttgtttat     9240

taggtggatt tttttccctg ggtactagct ctgtgaagga gataaaaagc gcaatgtgtg     9300

ttaaaaaaaa aaaattaaaa ttaaaatgaa aaaaagcttt ttttcttttc tttttaaatg     9360

tatttaaatt ctgtttctct cttctgttac tttacacgta tgaatgctct gctcttctgt     9420

gatcttaaaa caaaatgaaa taaacgtgaa aaggagatgt gtcttcattg acctgtca       9478


<210> 3
<211> 7895
<212> DNA
<213> Homo sapiens

<400> 3
aagcggcatc acaggctgtc aacaaccggg tctctatttt ctctcctcct ccggcgcccc       60

gcccgtgcgg gacatcagct cccaggatgc gtcaatcgca gatcgcccaa gcgtaagagg      120

tggcgagagg ccaccacggt tgcccaacag ttgcgttccc aggctgcctg gtgtgacgca      180

gcagcccccg cccggaccct gaggcctggc gctccgactg agccgaggcc tgtgctaccc      240

gacactcctt gcgacccggc cccttaggct tattcagcgc ggcccttccc ggcttcccga      300

gtcccatcgc agtctctccc cacccccgtt cctccccggt tccttgtcag tgtccgccgc      360

gatgtccttg cgcaaccatc ccaagtgaca ttagcgccca tacccgcacg gagcgagcct      420

gaagctccca cttcccggaa ttcaacgccg ggccgctaag ggcgggcacc caagcgagga      480

tcagcggact aaggccgcga ccagagtcca gcggtctccg cgcagtcaga gtccgacagc      540

ctctgcgcat ccgccgtgcg cactcccatt cgtgcgcgtg cgcgcactcg ccccccccgc      600

cccgccccag caccaatcgc ttttttccta cgcccacgac ccttcaacgt agtccctccc      660

gcctcccgcg cgcgagcaga aaggcttcgg cgtgcgcgcg cccgcccgcc tcgcgctctg      720

tcgggaaggg gagtgagcag aggcgcttac gtcgcgcggg aggcggaggc gacggcgacc      780

tcggtggcgg cggcggctac gacggagacg gttgcgctcg cttgctttct cggcgtcatg      840

gcggctgccg ggggcagata agcggaggga gcgggagcgc gcgcgcgacg gcggcggcgg      900

cggcggcgac gactggttac ttatagctct tgctgccctc gcccttggtg cttcaataat      960

gaattgttag ctccactccg caggggatcg cgcgttggtg ctgcggaccg gggcttcccc     1020

ttcccctccg cgtctgtccc cttccccctc ccccgcacgg actcttgctt accccgagac     1080

gccggagccc taggactggg cggcggagat cccgggcctg ggcgcggggg aggccgtcca     1140

cccgagtcgg ctccctccgc cccgccaagc ccgccggtga atcaaaggag agtcccagaa     1200

aacctgtgac tgttgaagaa aattcatctg tgaattttta tattcaagga gtcagtattt     1260

atattcatct tttaaactgg gaagatttat attttacttt aaaacttctt gataataatt     1320

tacaatgaat ggacacagtg atgaagaaag tgttagaaac agtagtggag aatcaagcca     1380

gtcggatgat gattctgggt cagcttcagg ctctggatct ggttcgagtt ctggaagcag     1440

tagtgatgga agcagtagcc agtcaggtag cagtgactct gactccggat ctgaatcagg     1500

cagtcagtca gagtctgagt cagacacttc ccgagaaaac aaagttcaag caaaaccacc     1560

gaaagttgat ggagctgagt tttggaaatc tagtcctagt attctggccg ttcagagatc     1620

tgcaatcctc aagaagcagc aacagcagca gcagcaacaa caacatcaag cctcatctaa     1680

tagcggatca gaagaggatt cctctagcag tgaagattcc gatgactcat caagtgaggt     1740

caaaaggaaa aagcataaag atgaagattg gcaaatgtct gggtcaggat ctccatctca     1800

gtctggttca gattcagaat ctgaagaaga gagagagaaa agcagttgtg atgaaacaga     1860

atctgattat gagccaaaaa acaaagtcaa aagcagaaaa cctcaaaata gatctaagtc     1920

aaaaaatgga aagaagattc ttggacaaaa aaagagacag attgattcat ctgaggagga     1980

tgatgatgaa gaagattatg ataatgataa aagaagttct cgtcgccaag caactgttaa     2040

tgttagctat aaggaggatg aagaaatgaa aacagattct gatgacctac tggaagtctg     2100

tggagaggat gttcctcaac ctgaggaaga ggaatttgaa accatagaaa gatttatgga     2160

ttgtcggatt gggagaaaag gagctactgg tgctactaca accatctatg cagttgaagc     2220

agatggtgac ccaaatgcag gctttgaaaa aaacaaagaa ccaggagaga ttcagtattt     2280

aattaaatgg aaaggatggt cccatatcca caacacttgg gagacagaag aaaccctcaa     2340

gcagcagaat gttagaggaa tgaaaaaatt ggataattat aagaaaaaag atcaggaaac     2400

aaaaagatgg ttgaaaaatg cctctccaga agatgtggaa tattataatt gccagcaaga     2460

acttacagat gatctacata aacagtatca aatagtggaa cgtataattg ctcattccaa     2520

tcaaaagtca gcagctggtt atcctgatta ttactgcaaa tggcagggcc ttccatactc     2580

agagtgcagc tgggaagatg gagctctcat ttccaaaaag tttcaagcat gcattgatga     2640

gtattttagc aggaaccaat caaaaaccac tccttttaaa gattgcaaag tattaaaaca     2700

aaggccaagg tttgtagccc tgaagaagca gccatcctat attggaggac atgagggctt     2760

agaattaaga gattatcaac tgaatggttt aaattggctt gctcattctt ggtgcaaagg     2820

aaatagttgc atactcgctg atgaaatggg ccttggaaaa acaatacaga cgatctcatt     2880

tctgaattat ttgtttcatg aacatcaatt atatggacct tttttattgg tagtaccgct     2940

ctccactctt acttcctggc aaagggaaat tcagacttgg gcttctcaaa tgaatgctgt     3000

ggtttattta ggtgacatta acagcagaaa catgataaga actcatgaat ggacgcatca     3060

tcagaccaaa cggttaaaat ttaatatatt gttaacaact tatgaaattt tattaaaaga     3120

taaggcattc cttggaggtc taaattgggc atttataggt gttgatgaag cacaccgatt     3180

aaagaatgat gactcccttc tgtataaaac tttaatagat tttaaatcca atcatcgtct     3240

ccttatcact ggaactcctc tacagaattc cctcaaagag ctctggtctt tgctacattt     3300

cattatgcca gaaaagtttt cttcctggga agattttgaa gaagaacatg gcaaagggag     3360

agaatatggt tatgcaagcc ttcacaagga gcttgagcca tttctgttac gccgagttaa     3420

gaaagatgtg gaaaaatctc ttcctgccaa ggttgagcag attttaagaa tggaaatgag     3480

tgctttacag aaacaatatt acaaatggat tttaactagg aattacaaag ccctcagcaa     3540

aggttccaag ggcagtacct caggcttttt gaacattatg atggagctaa agaaatgttg     3600

taaccattgc tacctcatta aaccaccaga taataatgaa ttctataata aacaggaggc     3660

cttacaacac ttaattcgta gtagcggaaa attgattctt cttgacaagc tattaattcg     3720

cctaagagaa cgaggcaatc gagttcttat tttttcacaa atggtgcgga tgttagatat     3780

acttgcagaa tatttgaaat atcgtcaatt cccctttcaa agattagatg gatcaataaa     3840

aggagaactg aggaaacaag ctctagatca ttttaatgct gagggatcag aggatttttg     3900

ctttttgctg tccacaagag ctggaggtct agggattaat ttagcctctg ctgacactgt     3960

tgttatattt gattccgatt ggaatccaca gaatgatctt caggcacagg ctagagccca     4020

tcgaattggg caaaagaaac aggtgaatat ttatcgtcta gttacaaagg gatcagttga     4080

agaagatatt cttgaaaggg cgaaaaagaa gatggtttta gatcatcttg taattcaaag     4140

aatggacaca actgggaaga cagtactaca tacaggttct gccccatcaa gttctactcc     4200

tttcaataaa gaagagttat cagccatttt aaagtttggt gctgaagaac tttttaagga     4260

acctgaagga gaagaacaag agccccagga aatggatata gatgaaatct tgaagagagc     4320

tgaaactcat gaaaatgaac caggtccttt aactgtagga gatgaattgc tttcccagtt     4380

caaggttgcc aacttctcaa atatggatga ggatgacatt gagttggaac ctgaaagaaa     4440

ttcaaagaat tgggaggaaa ttattccaga agatcaaaga agacgattag aagaagaaga     4500

aagacaaaag gaacttgaag aaatttatat gctcccaaga atgagaaatt gtgcaaaaca     4560

gattagtttc aatggaagtg aagggaggcg cagtagaagt aggagatact ctggatctga     4620

tagtgattcc atctcagaag ggaaaaggcc aaagaaacgt ggaagaccac ggactattcc     4680

tcgggagaat attaaaggat ttagtgatgc agaaattagg cggtttatca agagctataa     4740

gaaatttggt ggtcctctgg aaagattaga tgcaattgct cgagatgctg agttagttga     4800

taagtcagaa acagacctta gacgactggg agaattggta cataatggtt gcattaaagc     4860

attaaaggat agttcttcag gaacagaacg aacaggtggt agactcggaa aagtgaaggg     4920

tccaacattc cgaatatcag gagtacaggt gaatgccaaa ctagtcatct cccatgaaga     4980

agaattaata cctttgcaca aatccattcc ttctgatcca gaagaaagaa agcagtatac     5040

tatcccatgc cacacaaagg cagctcattt tgatatagac tggggcaaag aagatgattc     5100

caatttgtta attggcatct atgaatatgg atatggaagc tgggaaatga ttaaaatgga     5160

tcctgacctc agtctaacac acaagattct tccagatgat cccgataaaa aaccacaagc     5220

aaaacagttg cagacccgtg cagactacct catcaaatta cttagtagag atcttgcaaa     5280

aaaagaagct ctttctggtg cgggaagttc aaagaggaga aaagcaagag ctaagaagaa     5340

taaagcaatg aagtctataa aagtgaaaga ggaaataaag agtgattctt ctcctctgcc     5400

ttcagagaag tctgatgaag atgatgataa agatgagatc agttctgtga aacatccaaa     5460

taaaaaaatt aaaacagaaa gagacagtga agaaaaacct gagccagatg tttatataaa     5520

gaaggaacca gaagaaaaga gggaagcaaa agaaaaggag aataaaaaag aacttaaaag     5580

ggagataaaa gaaaaagagg ataagaaaga tataaaggaa aaagatttta aagaaaaaag     5640

agaaaacaaa gtaaaagaag ctatacagaa agaaaaagac ataaaggaag aaaagttgag     5700

tgaatccaag tctgatggta gggaaagatc caagaaatct tcagtgtcag atgctccagt     5760

tcatatcacg gcaagtggtg aaccagttcc catttctgaa gaatctgaag agctggatca     5820

gaagacattc agcatttgta aagaaagaat gaggcctgtt aaagcagctt tgaaacaact     5880

tgataggcct gagaaaggcc tttcagaaag agaacaacta gagcatacta gacaatgttt     5940

aataaaaatt ggagaccata tcacagaatg tctaaaagag tatacaaatc ctgaacaaat     6000

taagcaatgg agaaaaaacc tgtggatttt tgtatctaag tttactgaat ttgatgcaag     6060

aaaattacat aaattatata agcatgctat taaaaaacgg caggagtctc agcaaaacag     6120

tgatcaaaac agcaacttga atcctcacgt gattagaaat ccagatgtgg aaagattaaa     6180

agagaataca aatcacgatg atagcagcag ggacagttat tcctctgata gacacttaac     6240

tcagtaccat gatcatcata aagaccgaca tcagggagat tcttacaaaa aaagtgattc     6300

caggaaaaga ccctattctt cttttagtaa tggtaaagac catcgtgatt gggatcacta     6360

caagcaagac agcagatatt acagtgacag agagaaacac agaaaactgg atgatcacag     6420

gagtagagat cacaggtcaa atttggaagg aagtttaaaa gatagatctc attctgatca     6480

tcgttctcac tcagatcatc ggttacattc agaccaccgg tcaagttctg aatatacgca     6540

ccataaatct tccagggatt ataggtatca ctcagactgg caaatggacc acagagcttc     6600

cagcagtggc cctaggtcac cactagatca gagatctcct tatggctcca gatctccatt     6660

tgaacattca gttgaacaca aaagtacacc ggagcatacc tggagtagtc ggaaaacata     6720

acaaaaactg atacttcgtc tttctggact tttcttttag ccatatatca taaaccaaca     6780

cagtaattgc cttacatgac ttgaaagata taaacagatc ttctatcagt agcagtattg     6840

ttacttcttt ccaggatgca aggtctatta tcccaacaga agagaaaata tttttatatt     6900

taaggattat gctgcactgt actacaaaat tgtagtactt ttttttgttt tcttttttaa     6960

agaaatggaa aatgtttact attacaggga cctcaacact gccctcccat acaggctgga     7020

taaaactgtt tttaagtcag tgattttaga ctgacctcca tttaaattat gtttatatat     7080

gaactttact ctgacctgtg atcatgtttc aggaaggaat gaaagagagt tctttcttaa     7140

taaagaaaaa cactcaagga ctttgttcat ttccaaagct acttgtttac attgtacact     7200

gcgaccacct tgccgctttt catcacaagc ttgaatattt aaattctgta cttatatctg     7260

taaaatagcc aggaatttcc tgtttgtgat ctattatgcc tttttacaaa aaaaatggct     7320

gtaaattatt gtaaatatta aaggaacttt ccttacttcc ttccctttct caggcttttt     7380

ttgactgttc ctttccctac caactcaggc cttcttatta aaaaaaaaaa aatcagtgta     7440

ataacacttt ttaatgattt gtcttgatgg aatcattgtt tagaatgtaa aaatggggaa     7500

aggggccact taattccatt agtcctcttt ttatactgaa tattttatta gatacatgtt     7560

attccctttt ttttcctttt ttagtcaata ttgtgtttgt agttttaaaa aatggcgaga     7620

tatgtaaaat ctaaactgca tgctctggaa acactttttt cagatgcatc tggtttaaaa     7680

gggtaggtgt ataaacactt ttcagaatcc aaaacggcca aaagttattg taaatccgtt     7740

tgttttcccg ttttatgtgg gcaataatgt caaatgtgct atgcagccag gttaacattt     7800

tagataaact tgattgactt ttaatataaa ctgttacaat gcacactgat tgtatataaa     7860

aacgttatat atgacaaatt aaatttaaga aaaag                                7895


<210> 4
<211> 741
<212> PRT
<213> Homo sapiens

<400> 4
Met Leu Glu Arg Lys Lys Pro Lys Thr Ala Glu Asn Gln Lys Ala Ser 
1               5                   10                  15      


Glu Glu Asn Glu Ile Thr Gln Pro Gly Gly Ser Ser Ala Lys Pro Gly 
            20                  25                  30          


Leu Pro Cys Leu Asn Phe Glu Ala Val Leu Ser Pro Asp Pro Ala Leu 
        35                  40                  45              


Ile His Ser Thr His Ser Leu Thr Asn Ser His Ala His Thr Gly Ser 
    50                  55                  60                  


Ser Asp Cys Asp Ile Ser Cys Lys Gly Met Thr Glu Arg Ile His Ser 
65                  70                  75                  80  


Ile Asn Leu His Asn Phe Ser Asn Ser Val Leu Glu Thr Leu Asn Glu 
                85                  90                  95      


Gln Arg Asn Arg Gly His Phe Cys Asp Val Thr Val Arg Ile His Gly 
            100                 105                 110         


Ser Met Leu Arg Ala His Arg Cys Val Leu Ala Ala Gly Ser Pro Phe 
        115                 120                 125             


Phe Gln Asp Lys Leu Leu Leu Gly Tyr Ser Asp Ile Glu Ile Pro Ser 
    130                 135                 140                 


Val Val Ser Val Gln Ser Val Gln Lys Leu Ile Asp Phe Met Tyr Ser 
145                 150                 155                 160 


Gly Val Leu Arg Val Ser Gln Ser Glu Ala Leu Gln Ile Leu Thr Ala 
                165                 170                 175     


Ala Ser Ile Leu Gln Ile Lys Thr Val Ile Asp Glu Cys Thr Arg Ile 
            180                 185                 190         


Val Ser Gln Asn Val Gly Asp Val Phe Pro Gly Ile Gln Asp Ser Gly 
        195                 200                 205             


Gln Asp Thr Pro Arg Gly Thr Pro Glu Ser Gly Thr Ser Gly Gln Ser 
    210                 215                 220                 


Ser Asp Thr Glu Ser Gly Tyr Leu Gln Ser His Pro Gln His Ser Val 
225                 230                 235                 240 


Asp Arg Ile Tyr Ser Ala Leu Tyr Ala Cys Ser Met Gln Asn Gly Ser 
                245                 250                 255     


Gly Glu Arg Ser Phe Tyr Ser Gly Ala Val Val Ser His His Glu Thr 
            260                 265                 270         


Ala Leu Gly Leu Pro Arg Asp His His Met Glu Asp Pro Ser Trp Ile 
        275                 280                 285             


Thr Arg Ile His Glu Arg Ser Gln Gln Met Glu Arg Tyr Leu Ser Thr 
    290                 295                 300                 


Thr Pro Glu Thr Thr His Cys Arg Lys Gln Pro Arg Pro Val Arg Ile 
305                 310                 315                 320 


Gln Thr Leu Val Gly Asn Ile His Ile Lys Gln Glu Met Glu Asp Asp 
                325                 330                 335     


Tyr Asp Tyr Tyr Gly Gln Gln Arg Val Gln Ile Leu Glu Arg Asn Glu 
            340                 345                 350         


Ser Glu Glu Cys Thr Glu Asp Thr Asp Gln Ala Glu Gly Thr Glu Ser 
        355                 360                 365             


Glu Pro Lys Gly Glu Ser Phe Asp Ser Gly Val Ser Ser Ser Ile Gly 
    370                 375                 380                 


Thr Glu Pro Asp Ser Val Glu Gln Gln Phe Gly Pro Gly Ala Ala Arg 
385                 390                 395                 400 


Asp Ser Gln Ala Glu Pro Thr Gln Pro Glu Gln Ala Ala Glu Ala Pro 
                405                 410                 415     


Ala Glu Gly Gly Pro Gln Thr Asn Gln Leu Glu Thr Gly Ala Ser Ser 
            420                 425                 430         


Pro Glu Arg Ser Asn Glu Val Glu Met Asp Ser Thr Val Ile Thr Val 
        435                 440                 445             


Ser Asn Ser Ser Asp Lys Ser Val Leu Gln Gln Pro Ser Val Asn Thr 
    450                 455                 460                 


Ser Ile Gly Gln Pro Leu Pro Ser Thr Gln Leu Tyr Leu Arg Gln Thr 
465                 470                 475                 480 


Glu Thr Leu Thr Ser Asn Leu Arg Met Pro Leu Thr Leu Thr Ser Asn 
                485                 490                 495     


Thr Gln Val Ile Gly Thr Ala Gly Asn Thr Tyr Leu Pro Ala Leu Phe 
            500                 505                 510         


Thr Thr Gln Pro Ala Gly Ser Gly Pro Lys Pro Phe Leu Phe Ser Leu 
        515                 520                 525             


Pro Gln Pro Leu Ala Gly Gln Gln Thr Gln Phe Val Thr Val Ser Gln 
    530                 535                 540                 


Pro Gly Leu Ser Thr Phe Thr Ala Gln Leu Pro Ala Pro Gln Pro Leu 
545                 550                 555                 560 


Ala Ser Ser Ala Gly His Ser Thr Ala Ser Gly Gln Gly Glu Lys Lys 
                565                 570                 575     


Pro Tyr Glu Cys Thr Leu Cys Asn Lys Thr Phe Thr Ala Lys Gln Asn 
            580                 585                 590         


Tyr Val Lys His Met Phe Val His Thr Gly Glu Lys Pro His Gln Cys 
        595                 600                 605             


Ser Ile Cys Trp Arg Ser Phe Ser Leu Lys Asp Tyr Leu Ile Lys His 
    610                 615                 620                 


Met Val Thr His Thr Gly Val Arg Ala Tyr Gln Cys Ser Ile Cys Asn 
625                 630                 635                 640 


Lys Arg Phe Thr Gln Lys Ser Ser Leu Asn Val His Met Arg Leu His 
                645                 650                 655     


Arg Gly Glu Lys Ser Tyr Glu Cys Tyr Ile Cys Lys Lys Lys Phe Ser 
            660                 665                 670         


His Lys Thr Leu Leu Glu Arg His Val Ala Leu His Ser Ala Ser Asn 
        675                 680                 685             


Gly Thr Pro Pro Ala Gly Thr Pro Pro Gly Ala Arg Ala Gly Pro Pro 
    690                 695                 700                 


Gly Val Val Ala Cys Thr Glu Gly Thr Thr Tyr Val Cys Ser Val Cys 
705                 710                 715                 720 


Pro Ala Lys Phe Asp Gln Ile Glu Gln Phe Asn Asp His Met Arg Met 
                725                 730                 735     


His Val Ser Asp Gly 
            740     


<210> 5
<211> 3317
<212> DNA
<213> Homo sapiens

<400> 5
gttgggaaac agcccagtgg tataaggatg aggaaactga agcccagaga ggtgaagtga       60

ggtgcccaag gccacacagc aagttagagg cacagctagt acggtagctc aagtctcctg      120

actcccagtc cagtgctcct cccattactc cacgagtcct gtctctaagc ttcctgacaa      180

atgctagaac ggaagaaacc caagacagct gaaaaccaga aggcatctga ggagaatgag      240

attactcagc cgggtggatc cagcgccaag ccgggccttc cctgcctgaa ctttgaagct      300

gttttgtctc cagacccagc cctcatccac tcaacacatt cactgacaaa ctctcacgct      360

cacaccgggt catctgattg tgacatcagt tgcaagggga tgaccgagcg cattcacagc      420

atcaaccttc acaacttcag caattccgtg ctcgagaccc tcaacgagca gcgcaaccgt      480

ggccacttct gtgacgtaac ggtgcgcatc cacgggagca tgctgcgcgc acaccgctgc      540

gtgctggcag ccggcagccc cttcttccag gacaaactgc tgcttggcta cagcgacatc      600

gagatcccgt cggtggtgtc agtgcagtca gtgcaaaagc tcattgactt catgtacagc      660

ggcgtgctac gggtctcgca gtcggaagct ctgcagatcc tcacggccgc cagcatcctg      720

cagatcaaaa cagtcatcga cgagtgcacg cgcatcgtgt cacagaacgt gggcgatgtg      780

ttcccgggga tccaggactc gggccaggac acgccgcggg gcactcccga gtcaggcacg      840

tcaggccaga gcagcgacac ggagtcgggc tacctgcaga gccacccaca gcacagcgtg      900

gacaggatct actcggcact ctacgcgtgc tccatgcaga atggcagcgg cgagcgctct      960

ttttacagcg gcgcagtggt cagccaccac gagactgcgc tcggcctgcc ccgcgaccac     1020

cacatggaag accccagctg gatcacacgc atccatgagc gctcgcagca gatggagcgc     1080

tacctgtcca ccacccccga gaccacgcac tgccgcaagc agccccggcc tgtgcgcatc     1140

cagaccctag tgggcaacat ccacatcaag caggagatgg aggacgatta cgactactac     1200

gggcagcaaa gggtgcagat cctggaacgc aacgaatccg aggagtgcac ggaagacaca     1260

gaccaggccg agggcaccga gagtgagccc aaaggtgaaa gcttcgactc gggcgtcagc     1320

tcctccatag gcaccgagcc tgactcggtg gagcagcagt ttgggcctgg ggcggcgcgg     1380

gacagccagg ctgaacccac ccaacccgag caggctgcag aagcccccgc tgagggtggt     1440

ccgcagacaa accagctaga aacaggtgct tcctctccgg agagaagcaa tgaagtggag     1500

atggacagca ctgttatcac tgtcagcaac agctccgaca agagcgtcct acaacagcct     1560

tcggtcaaca cgtccatcgg gcagccattg ccaagtaccc agctctactt acgccagaca     1620

gaaaccctca ccagcaacct gaggatgcct ctgaccttga ccagcaacac gcaggtcatt     1680

ggcacagctg gcaacaccta cctgccagcc ctcttcacta cccagcccgc gggcagtggc     1740

cccaagcctt tcctcttcag cctgccacag cccctggcag gccagcagac ccagtttgtg     1800

acagtgtccc agcccggtct gtcgaccttt actgcacagc tgccagcgcc acagcccctg     1860

gcctcatccg caggccacag cacagccagt gggcaaggcg aaaaaaagcc ttatgagtgc     1920

actctctgca acaagacttt caccgccaaa cagaactacg tcaagcacat gttcgtacac     1980

acaggtgaga agccccacca atgcagcatc tgttggcgct ccttctcctt aaaggattac     2040

cttatcaagc acatggtgac acacacagga gtgagggcat accagtgtag tatctgcaac     2100

aagcgcttca cccagaagag ctccctcaac gtgcacatgc gcctccaccg gggagagaag     2160

tcctacgagt gctacatctg caaaaagaag ttctctcaca agaccctcct ggagcgacac     2220

gtggccctgc acagtgccag caatgggacc ccccctgcag gcacaccccc aggtgcccgc     2280

gctggccccc caggcgtggt ggcctgcacg gaggggacca cttacgtctg ctccgtctgc     2340

ccagcaaagt ttgaccaaat cgagcagttc aacgaccaca tgaggatgca tgtgtctgac     2400

ggataagtag tatctttctc tctttcttat gaacaaaaca aaacaacaac aaaaaacaaa     2460

caaacaaaaa agctatggca ctagaattta agaaatgttt tggtttcatt tttactttct     2520

gtttttgttt ttgtttcgtt tcattttgta ctacatgaag aactgttttt tgcctgctgg     2580

tacattacat ttccggaggc ttgggtgaat aatagttttc ccagtctccc tcggatggtg     2640

gccttaaggc ctggtagtgc ttcaagaggt ccactggttg gatctctagc tactggcctc     2700

taaatacaac ccttctttac aaaaaaatct tttaaaaaaa agtaaaaaaa aaaaaaaaat     2760

ttccacttgt gaagagcact acaaaaaata tataacaaaa tctaaaaggc ctactgtctt     2820

taagtacacc gcttgcagtg tttcagtgga cattttcaca attctggccg cttggacttc     2880

acagtaacca gttaaaactg tggaatatca cttctggttg aaaacccaga ggaaaggccc     2940

tgctgttttc cacctaccac gttgtctgat ttcataaaag ggctgtgggg gtgggaaggg     3000

cagtgggttc ggtggtgtgg gaaagaaaga cgaatggcag gcttcttccc cagattctgc     3060

ccgggtccac acaccctggc ccaccttctc catatccccc tcttgcagca gaagccagga     3120

agacttggac aagcaacaag caacagtggc tatcgtattt attcagtgtc ttcgctgagc     3180

cacagcctca gcacaatcaa gagggacttt catgaaaggc aggaatgcag ataaaacaaa     3240

gatatcagaa atttgcacct atgtttctag gtacaagaga aggattattt ccaacaatct     3300

ttgcaaaaaa aaaaaaa                                                    3317


<210> 6
<211> 668
<212> PRT
<213> Homo sapiens

<400> 6
Met Thr Glu Arg Ile His Ser Ile Asn Leu His Asn Phe Ser Asn Ser 
1               5                   10                  15      


Val Leu Glu Thr Leu Asn Glu Gln Arg Asn Arg Gly His Phe Cys Asp 
            20                  25                  30          


Val Thr Val Arg Ile His Gly Ser Met Leu Arg Ala His Arg Cys Val 
        35                  40                  45              


Leu Ala Ala Gly Ser Pro Phe Phe Gln Asp Lys Leu Leu Leu Gly Tyr 
    50                  55                  60                  


Ser Asp Ile Glu Ile Pro Ser Val Val Ser Val Gln Ser Val Gln Lys 
65                  70                  75                  80  


Leu Ile Asp Phe Met Tyr Ser Gly Val Leu Arg Val Ser Gln Ser Glu 
                85                  90                  95      


Ala Leu Gln Ile Leu Thr Ala Ala Ser Ile Leu Gln Ile Lys Thr Val 
            100                 105                 110         


Ile Asp Glu Cys Thr Arg Ile Val Ser Gln Asn Val Gly Asp Val Phe 
        115                 120                 125             


Pro Gly Ile Gln Asp Ser Gly Gln Asp Thr Pro Arg Gly Thr Pro Glu 
    130                 135                 140                 


Ser Gly Thr Ser Gly Gln Ser Ser Asp Thr Glu Ser Gly Tyr Leu Gln 
145                 150                 155                 160 


Ser His Pro Gln His Ser Val Asp Arg Ile Tyr Ser Ala Leu Tyr Ala 
                165                 170                 175     


Cys Ser Met Gln Asn Gly Ser Gly Glu Arg Ser Phe Tyr Ser Gly Ala 
            180                 185                 190         


Val Val Ser His His Glu Thr Ala Leu Gly Leu Pro Arg Asp His His 
        195                 200                 205             


Met Glu Asp Pro Ser Trp Ile Thr Arg Ile His Glu Arg Ser Gln Gln 
    210                 215                 220                 


Met Glu Arg Tyr Leu Ser Thr Thr Pro Glu Thr Thr His Cys Arg Lys 
225                 230                 235                 240 


Gln Pro Arg Pro Val Arg Ile Gln Thr Leu Val Gly Asn Ile His Ile 
                245                 250                 255     


Lys Gln Glu Met Glu Asp Asp Tyr Asp Tyr Tyr Gly Gln Gln Arg Val 
            260                 265                 270         


Gln Ile Leu Glu Arg Asn Glu Ser Glu Glu Cys Thr Glu Asp Thr Asp 
        275                 280                 285             


Gln Ala Glu Gly Thr Glu Ser Glu Pro Lys Gly Glu Ser Phe Asp Ser 
    290                 295                 300                 


Gly Val Ser Ser Ser Ile Gly Thr Glu Pro Asp Ser Val Glu Gln Gln 
305                 310                 315                 320 


Phe Gly Pro Gly Ala Ala Arg Asp Ser Gln Ala Glu Pro Thr Gln Pro 
                325                 330                 335     


Glu Gln Ala Ala Glu Ala Pro Ala Glu Gly Gly Pro Gln Thr Asn Gln 
            340                 345                 350         


Leu Glu Thr Gly Ala Ser Ser Pro Glu Arg Ser Asn Glu Val Glu Met 
        355                 360                 365             


Asp Ser Thr Val Ile Thr Val Ser Asn Ser Ser Asp Lys Ser Val Leu 
    370                 375                 380                 


Gln Gln Pro Ser Val Asn Thr Ser Ile Gly Gln Pro Leu Pro Ser Thr 
385                 390                 395                 400 


Gln Leu Tyr Leu Arg Gln Thr Glu Thr Leu Thr Ser Asn Leu Arg Met 
                405                 410                 415     


Pro Leu Thr Leu Thr Ser Asn Thr Gln Val Ile Gly Thr Ala Gly Asn 
            420                 425                 430         


Thr Tyr Leu Pro Ala Leu Phe Thr Thr Gln Pro Ala Gly Ser Gly Pro 
        435                 440                 445             


Lys Pro Phe Leu Phe Ser Leu Pro Gln Pro Leu Ala Gly Gln Gln Thr 
    450                 455                 460                 


Gln Phe Val Thr Val Ser Gln Pro Gly Leu Ser Thr Phe Thr Ala Gln 
465                 470                 475                 480 


Leu Pro Ala Pro Gln Pro Leu Ala Ser Ser Ala Gly His Ser Thr Ala 
                485                 490                 495     


Ser Gly Gln Gly Glu Lys Lys Pro Tyr Glu Cys Thr Leu Cys Asn Lys 
            500                 505                 510         


Thr Phe Thr Ala Lys Gln Asn Tyr Val Lys His Met Phe Val His Thr 
        515                 520                 525             


Gly Glu Lys Pro His Gln Cys Ser Ile Cys Trp Arg Ser Phe Ser Leu 
    530                 535                 540                 


Lys Asp Tyr Leu Ile Lys His Met Val Thr His Thr Gly Val Arg Ala 
545                 550                 555                 560 


Tyr Gln Cys Ser Ile Cys Asn Lys Arg Phe Thr Gln Lys Ser Ser Leu 
                565                 570                 575     


Asn Val His Met Arg Leu His Arg Gly Glu Lys Ser Tyr Glu Cys Tyr 
            580                 585                 590         


Ile Cys Lys Lys Lys Phe Ser His Lys Thr Leu Leu Glu Arg His Val 
        595                 600                 605             


Ala Leu His Ser Ala Ser Asn Gly Thr Pro Pro Ala Gly Thr Pro Pro 
    610                 615                 620                 


Gly Ala Arg Ala Gly Pro Pro Gly Val Val Ala Cys Thr Glu Gly Thr 
625                 630                 635                 640 


Thr Tyr Val Cys Ser Val Cys Pro Ala Lys Phe Asp Gln Ile Glu Gln 
                645                 650                 655     


Phe Asn Asp His Met Arg Met His Val Ser Asp Gly 
            660                 665             


<210> 7
<211> 3541
<212> DNA
<213> Homo sapiens

<400> 7
gaagaagtag gggcgggggg aagtttagga gttgaggaaa gaagattaaa gagcgcgagg       60

agacaaataa aaagaagtgt taagaattgc ctttgggact ctgaaggctg aagaattgat      120

gaattgcaag tttgtgcccc atagctgcac agactgcctg aagttacatt tagagactga      180

aatcactgca ccttaaaaac aaaagattga gctgcactgt attcctaatg tttcatcatt      240

actaacagga tattcctcat gacattgctg tctgatcttt gaccatcagt ctgtgacctg      300

ccccttctct ttacatgcag ccgctctctg ctccctgccc caatgaacat ctgcactagg      360

cccaagcctt ggagtaattt acctgaagag tgacaccatt gattttgaaa ctactgaaga      420

aacccaagac agctgaaaac cagaaggcat ctgaggagaa tgagattact cagccgggtg      480

gatccagcgc caagccgggc cttccctgcc tgaactttga agctgttttg tctccagacc      540

cagccctcat ccactcaaca cattcactga caaactctca cgctcacacc gggtcatctg      600

attgtgacat cagttgcaag gggatgaccg agcgcattca cagcatcaac cttcacaact      660

tcagcaattc cgtgctcgag accctcaacg agcagcgcaa ccgtggccac ttctgtgacg      720

taacggtgcg catccacggg agcatgctgc gcgcacaccg ctgcgtgctg gcagccggca      780

gccccttctt ccaggacaaa ctgctgcttg gctacagcga catcgagatc ccgtcggtgg      840

tgtcagtgca gtcagtgcaa aagctcattg acttcatgta cagcggcgtg ctacgggtct      900

cgcagtcgga agctctgcag atcctcacgg ccgccagcat cctgcagatc aaaacagtca      960

tcgacgagtg cacgcgcatc gtgtcacaga acgtgggcga tgtgttcccg gggatccagg     1020

actcgggcca ggacacgccg cggggcactc ccgagtcagg cacgtcaggc cagagcagcg     1080

acacggagtc gggctacctg cagagccacc cacagcacag cgtggacagg atctactcgg     1140

cactctacgc gtgctccatg cagaatggca gcggcgagcg ctctttttac agcggcgcag     1200

tggtcagcca ccacgagact gcgctcggcc tgccccgcga ccaccacatg gaagacccca     1260

gctggatcac acgcatccat gagcgctcgc agcagatgga gcgctacctg tccaccaccc     1320

ccgagaccac gcactgccgc aagcagcccc ggcctgtgcg catccagacc ctagtgggca     1380

acatccacat caagcaggag atggaggacg attacgacta ctacgggcag caaagggtgc     1440

agatcctgga acgcaacgaa tccgaggagt gcacggaaga cacagaccag gccgagggca     1500

ccgagagtga gcccaaaggt gaaagcttcg actcgggcgt cagctcctcc ataggcaccg     1560

agcctgactc ggtggagcag cagtttgggc ctggggcggc gcgggacagc caggctgaac     1620

ccacccaacc cgagcaggct gcagaagccc ccgctgaggg tggtccgcag acaaaccagc     1680

tagaaacagg tgcttcctct ccggagagaa gcaatgaagt ggagatggac agcactgtta     1740

tcactgtcag caacagctcc gacaagagcg tcctacaaca gccttcggtc aacacgtcca     1800

tcgggcagcc attgccaagt acccagctct acttacgcca gacagaaacc ctcaccagca     1860

acctgaggat gcctctgacc ttgaccagca acacgcaggt cattggcaca gctggcaaca     1920

cctacctgcc agccctcttc actacccagc ccgcgggcag tggccccaag cctttcctct     1980

tcagcctgcc acagcccctg gcaggccagc agacccagtt tgtgacagtg tcccagcccg     2040

gtctgtcgac ctttactgca cagctgccag cgccacagcc cctggcctca tccgcaggcc     2100

acagcacagc cagtgggcaa ggcgaaaaaa agccttatga gtgcactctc tgcaacaaga     2160

ctttcaccgc caaacagaac tacgtcaagc acatgttcgt acacacaggt gagaagcccc     2220

accaatgcag catctgttgg cgctccttct ccttaaagga ttaccttatc aagcacatgg     2280

tgacacacac aggagtgagg gcataccagt gtagtatctg caacaagcgc ttcacccaga     2340

agagctccct caacgtgcac atgcgcctcc accggggaga gaagtcctac gagtgctaca     2400

tctgcaaaaa gaagttctct cacaagaccc tcctggagcg acacgtggcc ctgcacagtg     2460

ccagcaatgg gaccccccct gcaggcacac ccccaggtgc ccgcgctggc cccccaggcg     2520

tggtggcctg cacggagggg accacttacg tctgctccgt ctgcccagca aagtttgacc     2580

aaatcgagca gttcaacgac cacatgagga tgcatgtgtc tgacggataa gtagtatctt     2640

tctctctttc ttatgaacaa aacaaaacaa caacaaaaaa caaacaaaca aaaaagctat     2700

ggcactagaa tttaagaaat gttttggttt catttttact ttctgttttt gtttttgttt     2760

cgtttcattt tgtactacat gaagaactgt tttttgcctg ctggtacatt acatttccgg     2820

aggcttgggt gaataatagt tttcccagtc tccctcggat ggtggcctta aggcctggta     2880

gtgcttcaag aggtccactg gttggatctc tagctactgg cctctaaata caacccttct     2940

ttacaaaaaa atcttttaaa aaaaagtaaa aaaaaaaaaa aaatttccac ttgtgaagag     3000

cactacaaaa aatatataac aaaatctaaa aggcctactg tctttaagta caccgcttgc     3060

agtgtttcag tggacatttt cacaattctg gccgcttgga cttcacagta accagttaaa     3120

actgtggaat atcacttctg gttgaaaacc cagaggaaag gccctgctgt tttccaccta     3180

ccacgttgtc tgatttcata aaagggctgt gggggtggga agggcagtgg gttcggtggt     3240

gtgggaaaga aagacgaatg gcaggcttct tccccagatt ctgcccgggt ccacacaccc     3300

tggcccacct tctccatatc cccctcttgc agcagaagcc aggaagactt ggacaagcaa     3360

caagcaacag tggctatcgt atttattcag tgtcttcgct gagccacagc ctcagcacaa     3420

tcaagaggga ctttcatgaa aggcaggaat gcagataaaa caaagatatc agaaatttgc     3480

acctatgttt ctaggtacaa gagaaggatt atttccaaca atctttgcaa aaaaaaaaaa     3540

a                                                                     3541


<210> 8
<211> 3290
<212> DNA
<213> Homo sapiens

<400> 8
caccttctgc actgctcatc tgggcagagg aagcttcaga aagctgccaa ggcaccatct       60

ccaggaactc ccagcacgca gaatccatct gagaatatgc tgccacaaat accctttttg      120

ctgctagtat ccttgaactt ggttcatgga gtgttttacg ctgaacgata ccaaatgccc      180

acaggcataa aaggcccact acccaacacc aagacacagt tcttcattcc ctacaccata      240

aagagtaaag gtatagcagt aagaggagag caaggtactc ctggtccacc aggccctgct      300

ggacctcgag ggcacccagg tccttctgga ccaccaggaa aaccaggcta cggaagtcct      360

ggactccaag gagagccagg gttgccagga ccaccgggac catcagctgt agggaaacca      420

ggtgtgccag gactcccagg aaaaccagga gagagaggac catatggacc aaaaggagat      480

gttggaccag ctggcctacc aggaccccgg ggcccaccag gaccacctgg aatccctgga      540

ccggctggaa tttctgtgcc aggaaaacct ggacaacagg gacccacagg agccccagga      600

cccaggggct ttcctggaga aaagggtgca ccaggagtcc ctggtatgaa tggacagaaa      660

ggggaaatgg gatatggtgc tcctggtcgt ccaggtgaga ggggtcttcc aggccctcag      720

ggtcccacag gaccatctgg ccctcctgga gtgggaaaaa gaggtgaaaa tggggttcca      780

ggacagccag gcatcaaagg tgatagaggt tttccgggag aaatgggacc aattggccca      840

ccaggtcccc aaggccctcc tggggaacga gggccagaag gcattggaaa gccaggagct      900

gctggagccc caggccagcc agggattcca ggaacaaaag gtctccctgg ggctccagga      960

atagctgggc ccccagggcc tcctggcttt gggaaaccag gcttgccagg cctgaaggga     1020

gaaagaggac ctgctggcct tcctgggggt ccaggtgcca aaggggaaca agggccagca     1080

ggtcttcctg ggaagccagg tctgactgga ccccctggga atatgggacc ccaaggacca     1140

aaaggcatcc cgggtagcca tggtctccca ggccctaaag gtgagacagg gccagctggg     1200

cctgcaggat accctggggc taagggtgaa aggggttccc ctgggtcaga tggaaaacca     1260

gggtacccag gaaaaccagg tctcgatggt cctaagggta acccagggtt accaggtcca     1320

aaaggtgatc ctggagttgg aggacctcct ggtctcccag gccctgtggg cccagcagga     1380

gcaaagggaa tgcccggaca caatggagag gctggcccaa gaggtgcccc tggaatacca     1440

ggtactagag gccctattgg gccaccaggc attccaggat tccctgggtc taaaggggat     1500

ccaggaagtc ccggtcctcc tggcccagct ggcatagcaa ctaagggcct caatggaccc     1560

accgggccac cagggcctcc aggtccaaga ggccactctg gagagcctgg tcttccaggg     1620

ccccctgggc ctccaggccc accaggtcaa gcagtcatgc ctgagggttt tataaaggca     1680

ggccaaaggc ccagtctttc tgggacccct cttgttagtg ccaaccaggg ggtaacagga     1740

atgcctgtgt ctgcttttac tgttattctc tccaaagctt acccagcaat aggaactccc     1800

ataccatttg ataaaatttt gtataacagg caacagcatt atgacccaag gactggaatc     1860

tttacttgtc agataccagg aatatactat ttttcatacc acgtgcatgt gaaagggact     1920

catgtttggg taggcctgta taagaatggc acccctgtaa tgtacaccta tgatgaatac     1980

accaaaggct acctggatca ggcttcaggg agtgccatca tcgatctcac agaaaatgac     2040

caggtgtggc tccagcttcc caatgccgag tcaaatggcc tatactcctc tgagtatgtc     2100

cactcctctt tctcaggatt cctagtggct ccaatgtgag tacacacaga gctaatctaa     2160

atcttgtgct agaaaaagca ttctctaact ctaccccacc ctacaaaatg catatggagg     2220

taggctgaaa agaatgtaat ttttattttc tgaaatacag atttgagcta tcagaccaac     2280

aaaccttccc cctgaaaagt gagcagcaac gtaaaaacgt atgtgaagcc tctcttgaat     2340

ttctagttag caatcttaag gctctttaag gttttctcca atattaaaaa atatcaccaa     2400

agaagtcctg ctatgttaaa aacaaacaac aaaaaacaaa caacaaaaaa aaaattaaaa     2460

aaaaaaacag aaatagagct ctaagttatg tgaaatttga tttgagaaac tcggcatttc     2520

ctttttaaaa aagcctgttt ctaactatga atatgagaac ttctaggaaa catccaggag     2580

gtatcatata actttgtaga acttaaatac ttgaatattc aaatttaaaa gacactgtat     2640

cccctaaaat atttctgatg gtgcactact ctgaggcctg tatggcccct ttcatcaata     2700

tctattcaaa tatacaggtg catatatact tgttaaagct cttatataaa aaagccccaa     2760

aatattgaag ttcatctgaa atgcaaggtg ctttcatcaa tgaacctttt caaacttttc     2820

tatgattgca gagaagcttt ttatataccc agcataactt ggaaacaggt atctgaccta     2880

ttcttattta gttaacacaa gtgtgattaa tttgatttct ttaattcctt attgaatctt     2940

atgtgatatg attttctgga tttacagaac attagcacat gtaccttgtg cctcccattc     3000

aagtgaagtt ataatttaca ctgagggttt caaaattcga ctagaagtgg agatatatta     3060

tttatttatg cactgtactg tatttttata ttgctgttta aaacttttaa gctgtgcctc     3120

acttattaaa gcacaaaatg ttttacctac tccttattta cgacgcaata aaataacatc     3180

aatagatttt taggctgaat taatttgaaa gcagcaattt gctgttctca accattcttt     3240

caaggctttt cattgttcaa agttaataaa aaagtaggac aataaagtga                3290


<210> 9
<211> 264
<212> PRT
<213> Homo sapiens

<400> 9
Met Ile Met Ser Ser Tyr Leu Met Asp Ser Asn Tyr Ile Asp Pro Lys 
1               5                   10                  15      


Phe Pro Pro Cys Glu Glu Tyr Ser Gln Asn Ser Tyr Ile Pro Glu His 
            20                  25                  30          


Ser Pro Glu Tyr Tyr Gly Arg Thr Arg Glu Ser Gly Phe Gln His His 
        35                  40                  45              


His Gln Glu Leu Tyr Pro Pro Pro Pro Pro Arg Pro Ser Tyr Pro Glu 
    50                  55                  60                  


Arg Gln Tyr Ser Cys Thr Ser Leu Gln Gly Pro Gly Asn Ser Arg Gly 
65                  70                  75                  80  


His Gly Pro Ala Gln Ala Gly His His His Pro Glu Lys Ser Gln Ser 
                85                  90                  95      


Leu Cys Glu Pro Ala Pro Leu Ser Gly Ala Ser Ala Ser Pro Ser Pro 
            100                 105                 110         


Ala Pro Pro Ala Cys Ser Gln Pro Ala Pro Asp His Pro Ser Ser Ala 
        115                 120                 125             


Ala Ser Lys Gln Pro Ile Val Tyr Pro Trp Met Lys Lys Ile His Val 
    130                 135                 140                 


Ser Thr Val Asn Pro Asn Tyr Asn Gly Gly Glu Pro Lys Arg Ser Arg 
145                 150                 155                 160 


Thr Ala Tyr Thr Arg Gln Gln Val Leu Glu Leu Glu Lys Glu Phe His 
                165                 170                 175     


Tyr Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala His Ser 
            180                 185                 190         


Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg 
        195                 200                 205             


Met Lys Trp Lys Lys Asp His Arg Leu Pro Asn Thr Lys Val Arg Ser 
    210                 215                 220                 


Ala Pro Pro Ala Gly Ala Ala Pro Ser Thr Leu Ser Ala Ala Thr Pro 
225                 230                 235                 240 


Gly Thr Ser Glu Asp His Ser Gln Ser Ala Thr Pro Pro Glu Gln Gln 
                245                 250                 255     


Arg Ala Glu Asp Ile Thr Arg Leu 
            260                 


<210> 10
<211> 2459
<212> DNA
<213> Homo sapiens

<400> 10
acacacgtgt tacatggata cagctcctag ccagaagcaa gcaggctcta cccacacagg       60

cctccctctt agctagcggg ggctcaaccc ccagacctcc agaaatgacg tcagaatcat      120

ttgcatcccg ctgcctctac ctgcctggtc cagctgggac cctgcctcgc cggccgcatg      180

gccagagggt tgggtgagtg tgtatgggga agaggggctg gactctggta tccttggatg      240

gggggcactc caggctctcc agcctcctcg gctcagcctg ggcccctccc catccaacat      300

ccactccagt cctcattcaa cttcctcttc ctgcgaaaga ggggcgctgc cccgtgacct      360

acacagactg agacacgatc gccatgaatg gagacctctg gaaaagctca ggagccgagg      420

cccacggggc ccagcagagg cctgagggga gaccctgggc gggggctgaa tcactgcctc      480

ccgacagtcc cccaatgccc gggctttgga ggggagccgg gagcttccca tctccttttg      540

caggggaggg ttgtcagtct ggcgggatgt gcactggggg cactccaacc tctgctagct      600

aaccccacat caccacccac ccccgcctcc cagcaccacc accaccacac acacaaaaaa      660

attggataca ttttgaataa agcgattcgg ttccttatcc ggggactggg ttgctccgtg      720

tgattggccg gaggagtcac atggtgaaag taactttaca gggtcgctag ctagtaggag      780

ggctttatgg agcagaaaaa cgacaaagcg agaaaaatta ttttccactc cagaaattaa      840

tgatcatgag ctcgtatttg atggactcta actacatcga tccgaaattt cctccatgcg      900

aagaatattc gcaaaatagc tacatccctg aacacagtcc ggaatattac ggccggacca      960

gggaatcggg attccagcat caccaccagg agctgtaccc accaccgcct ccgcgcccta     1020

gctaccctga gcgccagtat agctgcacca gtctccaggg gcccggcaat tcgcgaggcc     1080

acgggccggc ccaggcgggc caccaccacc ccgagaaatc acagtcgctc tgcgagccgg     1140

cgcctctctc aggcgcctcc gcctccccgt ccccagcccc gccagcctgc agccagccag     1200

cccccgacca tccctccagc gccgccagca agcaacccat agtctaccca tggatgaaaa     1260

aaattcacgt tagcacggtg aaccccaatt ataacggagg ggaacccaag cgctcgagga     1320

cagcctatac ccggcagcaa gtcctggaat tagagaaaga gtttcattac aaccgctacc     1380

tgacccgaag gagaaggatc gagatcgccc actcgctgtg cctctctgag aggcagatca     1440

aaatctggtt ccaaaaccgt cgcatgaaat ggaagaagga ccaccgactc cccaacacca     1500

aagtcaggtc agcacccccg gccggcgctg cgcccagcac cctttcggca gctaccccgg     1560

gtacttctga agaccactcc cagagcgcca cgccgccgga gcagcaacgg gcagaggaca     1620

ttaccaggtt ataaaacata actcacaccc ctgcccccac cccatgcccc caccctcccc     1680

tcacacacaa attgactctt atttatagaa tttaatatat atatatatat atatatatat     1740

aggttctttt ctctcttcct ctcaccttgt cccttgtcag ttccaaacag acaaaacaga     1800

taaacaaaca agccccctgc cctcctctcc ctcccactgt taaggaccct tttaagcatg     1860

tgatgttgtc ttagcatggt acctgctggg tgtttttttt taaaaggcca ttttgggggg     1920

ttatttattt tttaagaaaa aaagctgcaa aaattatata ttgcaaggtg tgatggtctg     1980

gcttgggtga atttcagggg aaatgaggaa aagaaaaaag gaaagaaatt ttaaagccaa     2040

ttctcatcct tctcctcctc ctccttcccc ccctctttcc ttaggccttt tgcattgaaa     2100

atgcaccagg ggaggttagt gagggggaag tcattttaag gagaacaaag ctatgaagtt     2160

cttttgtatt attgttgggg gggggtgtgg gaggagaggg ggcgaagaca gcagacaaag     2220

ctaaatgcat ctggagagcc tctcagagct gttcagtttg aggagccaaa agaaaatcaa     2280

aatgaacttt cagttcagag aggcagtcta taggtagaat ctctccccac ccctatcgtg     2340

gttattgtgt ttttggactg aatttacttg attattgtaa aacttgcaat aaagaatttt     2400

agtgtcgatg tgaaatgccc cgtgatcaat aataaaccag tggatgtgaa ttagtttta      2459


<210> 11
<211> 2120
<212> PRT
<213> Homo sapiens

<400> 11
Met Arg Ser Phe Lys Arg Val Asn Phe Gly Thr Leu Leu Ser Ser Gln 
1               5                   10                  15      


Lys Glu Ala Glu Glu Leu Leu Pro Ala Leu Lys Glu Phe Leu Ser Asn 
            20                  25                  30          


Pro Pro Ala Gly Phe Pro Ser Ser Arg Ser Asp Ala Glu Arg Arg Gln 
        35                  40                  45              


Ala Cys Asp Ala Ile Leu Arg Ala Cys Asn Gln Gln Leu Thr Ala Lys 
    50                  55                  60                  


Leu Ala Cys Pro Arg His Leu Gly Ser Leu Leu Glu Leu Ala Glu Leu 
65                  70                  75                  80  


Ala Cys Asp Gly Tyr Leu Val Ser Thr Pro Gln Arg Pro Pro Leu Tyr 
                85                  90                  95      


Leu Glu Arg Ile Leu Phe Val Leu Leu Arg Asn Ala Ala Ala Gln Gly 
            100                 105                 110         


Ser Pro Glu Ala Thr Leu Arg Leu Ala Gln Pro Leu His Ala Cys Leu 
        115                 120                 125             


Val Gln Cys Ser Arg Glu Ala Ala Pro Gln Asp Tyr Glu Ala Val Ala 
    130                 135                 140                 


Arg Gly Ser Phe Ser Leu Leu Trp Lys Gly Ala Glu Ala Leu Leu Glu 
145                 150                 155                 160 


Arg Arg Ala Ala Phe Ala Ala Arg Leu Lys Ala Leu Ser Phe Leu Val 
                165                 170                 175     


Leu Leu Glu Asp Glu Ser Thr Pro Cys Glu Val Pro His Phe Ala Ser 
            180                 185                 190         


Pro Thr Ala Cys Arg Ala Val Ala Ala His Gln Leu Phe Asp Ala Ser 
        195                 200                 205             


Gly His Gly Leu Asn Glu Ala Asp Ala Asp Phe Leu Asp Asp Leu Leu 
    210                 215                 220                 


Ser Arg His Val Ile Arg Ala Leu Val Gly Glu Arg Gly Ser Ser Ser 
225                 230                 235                 240 


Gly Leu Leu Ser Pro Gln Arg Ala Leu Cys Leu Leu Glu Leu Thr Leu 
                245                 250                 255     


Glu His Cys Arg Arg Phe Cys Trp Ser Arg His His Asp Lys Ala Ile 
            260                 265                 270         


Ser Ala Val Glu Lys Ala His Ser Tyr Leu Arg Asn Thr Asn Leu Ala 
        275                 280                 285             


Pro Ser Leu Gln Leu Cys Gln Leu Gly Val Lys Leu Leu Gln Val Gly 
    290                 295                 300                 


Glu Glu Gly Pro Gln Ala Val Ala Lys Leu Leu Ile Lys Ala Ser Ala 
305                 310                 315                 320 


Val Leu Ser Lys Ser Met Glu Ala Pro Ser Pro Pro Leu Arg Ala Leu 
                325                 330                 335     


Tyr Glu Ser Cys Gln Phe Phe Leu Ser Gly Leu Glu Arg Gly Thr Lys 
            340                 345                 350         


Arg Arg Tyr Arg Leu Asp Ala Ile Leu Ser Leu Phe Ala Phe Leu Gly 
        355                 360                 365             


Gly Tyr Cys Ser Leu Leu Gln Gln Leu Arg Asp Asp Gly Val Tyr Gly 
    370                 375                 380                 


Gly Ser Ser Lys Gln Gln Gln Ser Phe Leu Gln Met Tyr Phe Gln Gly 
385                 390                 395                 400 


Leu His Leu Tyr Thr Val Val Val Tyr Asp Phe Ala Gln Gly Cys Gln 
                405                 410                 415     


Ile Val Asp Leu Ala Asp Leu Thr Gln Leu Val Asp Ser Cys Lys Ser 
            420                 425                 430         


Thr Val Val Trp Met Leu Glu Ala Leu Glu Gly Leu Ser Gly Gln Glu 
        435                 440                 445             


Leu Thr Asp His Met Gly Met Thr Ala Ser Tyr Thr Ser Asn Leu Ala 
    450                 455                 460                 


Tyr Ser Phe Tyr Ser His Lys Leu Tyr Ala Glu Ala Cys Ala Ile Ser 
465                 470                 475                 480 


Glu Pro Leu Cys Gln His Leu Gly Leu Val Lys Pro Gly Thr Tyr Pro 
                485                 490                 495     


Glu Val Pro Pro Glu Lys Leu His Arg Cys Phe Arg Leu Gln Val Glu 
            500                 505                 510         


Ser Leu Lys Lys Leu Gly Lys Gln Ala Gln Gly Cys Lys Met Val Ile 
        515                 520                 525             


Leu Trp Leu Ala Ala Leu Gln Pro Cys Ser Pro Glu His Met Ala Glu 
    530                 535                 540                 


Pro Val Thr Phe Trp Val Arg Val Lys Met Asp Ala Ala Arg Ala Gly 
545                 550                 555                 560 


Asp Lys Glu Leu Gln Leu Lys Thr Leu Arg Asp Ser Leu Ser Gly Trp 
                565                 570                 575     


Asp Pro Glu Thr Leu Ala Leu Leu Leu Arg Glu Glu Leu Gln Ala Tyr 
            580                 585                 590         


Lys Ala Val Arg Ala Asp Thr Gly Gln Glu Arg Phe Asn Ile Ile Cys 
        595                 600                 605             


Asp Leu Leu Glu Leu Ser Pro Glu Glu Thr Pro Ala Gly Ala Trp Ala 
    610                 615                 620                 


Arg Ala Thr His Leu Val Glu Leu Ala Gln Val Leu Cys Tyr His Asp 
625                 630                 635                 640 


Phe Thr Gln Gln Thr Asn Cys Ser Ala Leu Asp Ala Ile Arg Glu Ala 
                645                 650                 655     


Leu Gln Leu Leu Asp Ser Val Arg Pro Glu Ala Gln Ala Arg Asp Gln 
            660                 665                 670         


Leu Leu Asp Asp Lys Ala Gln Ala Leu Leu Trp Leu Tyr Ile Cys Thr 
        675                 680                 685             


Leu Glu Ala Lys Met Gln Glu Gly Ile Glu Arg Asp Arg Arg Ala Gln 
    690                 695                 700                 


Ala Pro Gly Asn Leu Glu Glu Phe Glu Val Asn Asp Leu Asn Tyr Glu 
705                 710                 715                 720 


Asp Lys Leu Gln Glu Asp Arg Phe Leu Tyr Ser Asn Ile Ala Phe Asn 
                725                 730                 735     


Leu Ala Ala Asp Ala Ala Gln Ser Lys Cys Leu Asp Gln Ala Leu Ala 
            740                 745                 750         


Leu Trp Lys Glu Leu Leu Thr Lys Gly Gln Ala Pro Ala Val Arg Cys 
        755                 760                 765             


Leu Gln Gln Thr Ala Ala Ser Leu Gln Ile Leu Ala Ala Leu Tyr Gln 
    770                 775                 780                 


Leu Val Ala Lys Pro Met Gln Ala Leu Glu Val Leu Leu Leu Leu Arg 
785                 790                 795                 800 


Ile Val Ser Glu Arg Leu Lys Asp His Ser Lys Ala Ala Gly Ser Ser 
                805                 810                 815     


Cys His Ile Thr Gln Leu Leu Leu Thr Leu Gly Cys Pro Ser Tyr Ala 
            820                 825                 830         


Gln Leu His Leu Glu Glu Ala Ala Ser Ser Leu Lys His Leu Asp Gln 
        835                 840                 845             


Thr Thr Asp Thr Tyr Leu Leu Leu Ser Leu Thr Cys Asp Leu Leu Arg 
    850                 855                 860                 


Ser Gln Leu Tyr Trp Thr His Gln Lys Val Thr Lys Gly Val Ser Leu 
865                 870                 875                 880 


Leu Leu Ser Val Leu Arg Asp Pro Ala Leu Gln Lys Ser Ser Lys Ala 
                885                 890                 895     


Trp Tyr Leu Leu Arg Val Gln Val Leu Gln Leu Val Ala Ala Tyr Leu 
            900                 905                 910         


Ser Leu Pro Ser Asn Asn Leu Ser His Ser Leu Trp Glu Gln Leu Cys 
        915                 920                 925             


Ala Gln Gly Trp Gln Thr Pro Glu Ile Ala Leu Ile Asp Ser His Lys 
    930                 935                 940                 


Leu Leu Arg Ser Ile Ile Leu Leu Leu Met Gly Ser Asp Ile Leu Ser 
945                 950                 955                 960 


Thr Gln Lys Ala Ala Val Glu Thr Ser Phe Leu Asp Tyr Gly Glu Asn 
                965                 970                 975     


Leu Val Gln Lys Trp Gln Val Leu Ser Glu Val Leu Ser Cys Ser Glu 
            980                 985                 990         


Lys Leu Val Cys His Leu Gly Arg  Leu Gly Ser Val Ser  Glu Ala Lys 
        995                 1000                 1005             


Ala Phe  Cys Leu Glu Ala Leu  Lys Leu Thr Thr Lys  Leu Gln Ile 
    1010                 1015                 1020             


Pro Arg  Gln Cys Ala Leu Phe  Leu Val Leu Lys Gly  Glu Leu Glu 
    1025                 1030                 1035             


Leu Ala  Arg Asn Asp Ile Asp  Leu Cys Gln Ser Asp  Leu Gln Gln 
    1040                 1045                 1050             


Val Leu  Phe Leu Leu Glu Ser  Cys Thr Glu Phe Gly  Gly Val Thr 
    1055                 1060                 1065             


Gln His  Leu Asp Ser Val Lys  Lys Val His Leu Gln  Lys Gly Lys 
    1070                 1075                 1080             


Gln Gln  Ala Gln Val Pro Cys  Pro Pro Gln Leu Pro  Glu Glu Glu 
    1085                 1090                 1095             


Leu Phe  Leu Arg Gly Pro Ala  Leu Glu Leu Val Ala  Thr Val Ala 
    1100                 1105                 1110             


Lys Glu  Pro Gly Pro Ile Ala  Pro Ser Thr Asn Ser  Ser Pro Val 
    1115                 1120                 1125             


Leu Lys  Thr Lys Pro Gln Pro  Ile Pro Asn Phe Leu  Ser His Ser 
    1130                 1135                 1140             


Pro Thr  Cys Asp Cys Ser Leu  Cys Ala Ser Pro Val  Leu Thr Ala 
    1145                 1150                 1155             


Val Cys  Leu Arg Trp Val Leu  Val Thr Ala Gly Val  Arg Leu Ala 
    1160                 1165                 1170             


Met Gly  His Gln Ala Gln Gly  Leu Asp Leu Leu Gln  Val Val Leu 
    1175                 1180                 1185             


Lys Gly  Cys Pro Glu Ala Ala  Glu Arg Leu Thr Gln  Ala Leu Gln 
    1190                 1195                 1200             


Ala Ser  Leu Asn His Lys Thr  Pro Pro Ser Leu Val  Pro Ser Leu 
    1205                 1210                 1215             


Leu Asp  Glu Ile Leu Ala Gln  Ala Tyr Thr Leu Leu  Ala Leu Glu 
    1220                 1225                 1230             


Gly Leu  Asn Gln Pro Ser Asn  Glu Ser Leu Gln Lys  Val Leu Gln 
    1235                 1240                 1245             


Ser Gly  Leu Lys Phe Val Ala  Ala Arg Ile Pro His  Leu Glu Pro 
    1250                 1255                 1260             


Trp Arg  Ala Ser Leu Leu Leu  Ile Trp Ala Leu Thr  Lys Leu Gly 
    1265                 1270                 1275             


Gly Leu  Ser Cys Cys Thr Thr  Gln Leu Phe Ala Ser  Ser Trp Gly 
    1280                 1285                 1290             


Trp Gln  Pro Pro Leu Ile Lys  Ser Val Pro Gly Ser  Glu Pro Ser 
    1295                 1300                 1305             


Lys Thr  Gln Gly Gln Lys Arg  Ser Gly Arg Gly Arg  Gln Lys Leu 
    1310                 1315                 1320             


Ala Ser  Ala Pro Leu Arg Leu  Asn Asn Thr Ser Gln  Lys Gly Leu 
    1325                 1330                 1335             


Glu Gly  Arg Gly Leu Pro Cys  Thr Pro Lys Pro Pro  Asp Arg Ile 
    1340                 1345                 1350             


Arg Gln  Ala Gly Pro His Val  Pro Phe Thr Val Phe  Glu Glu Val 
    1355                 1360                 1365             


Cys Pro  Thr Glu Ser Lys Pro  Glu Val Pro Gln Ala  Pro Arg Val 
    1370                 1375                 1380             


Gln Gln  Arg Val Gln Thr Arg  Leu Lys Val Asn Phe  Ser Asp Asp 
    1385                 1390                 1395             


Ser Asp  Leu Glu Asp Pro Val  Ser Ala Glu Ala Trp  Leu Ala Glu 
    1400                 1405                 1410             


Glu Pro  Lys Arg Arg Gly Thr  Ala Ser Arg Gly Arg  Gly Arg Ala 
    1415                 1420                 1425             


Arg Lys  Gly Leu Ser Leu Lys  Thr Asp Ala Val Val  Ala Pro Gly 
    1430                 1435                 1440             


Ser Ala  Pro Gly Asn Pro Gly  Leu Asn Gly Arg Ser  Arg Arg Ala 
    1445                 1450                 1455             


Lys Lys  Val Ala Ser Arg His  Cys Glu Glu Arg Arg  Pro Gln Arg 
    1460                 1465                 1470             


Ala Ser  Asp Gln Ala Arg Pro  Gly Pro Glu Ile Met  Arg Thr Ile 
    1475                 1480                 1485             


Pro Glu  Glu Glu Leu Thr Asp  Asn Trp Arg Lys Met  Ser Phe Glu 
    1490                 1495                 1500             


Ile Leu  Arg Gly Ser Asp Gly  Glu Asp Ser Ala Ser  Gly Gly Lys 
    1505                 1510                 1515             


Thr Pro  Ala Pro Gly Pro Glu  Ala Ala Ser Gly Glu  Trp Glu Leu 
    1520                 1525                 1530             


Leu Arg  Leu Asp Ser Ser Lys  Lys Lys Leu Pro Ser  Pro Cys Pro 
    1535                 1540                 1545             


Asp Lys  Glu Ser Asp Lys Asp  Leu Gly Pro Arg Leu  Arg Leu Pro 
    1550                 1555                 1560             


Ser Ala  Pro Val Ala Thr Gly  Leu Ser Thr Leu Asp  Ser Ile Cys 
    1565                 1570                 1575             


Asp Ser  Leu Ser Val Ala Phe  Arg Gly Ile Ser His  Cys Pro Pro 
    1580                 1585                 1590             


Ser Gly  Leu Tyr Ala His Leu  Cys Arg Phe Leu Ala  Leu Cys Leu 
    1595                 1600                 1605             


Gly His  Arg Asp Pro Tyr Ala  Thr Ala Phe Leu Val  Thr Glu Ser 
    1610                 1615                 1620             


Val Ser  Ile Thr Cys Arg His  Gln Leu Leu Thr His  Leu His Arg 
    1625                 1630                 1635             


Gln Leu  Ser Lys Ala Gln Lys  His Arg Gly Ser Leu  Glu Ile Ala 
    1640                 1645                 1650             


Asp Gln  Leu Gln Gly Leu Ser  Leu Gln Glu Met Pro  Gly Asp Val 
    1655                 1660                 1665             


Pro Leu  Ala Arg Ile Gln Arg  Leu Phe Ser Phe Arg  Ala Leu Glu 
    1670                 1675                 1680             


Ser Gly  His Phe Pro Gln Pro  Glu Lys Glu Ser Phe  Gln Glu Arg 
    1685                 1690                 1695             


Leu Ala  Leu Ile Pro Ser Gly  Val Thr Val Cys Val  Leu Ala Leu 
    1700                 1705                 1710             


Ala Thr  Leu Gln Pro Gly Thr  Val Gly Asn Thr Leu  Leu Leu Thr 
    1715                 1720                 1725             


Arg Leu  Glu Lys Asp Ser Pro  Pro Val Ser Val Gln  Ile Pro Thr 
    1730                 1735                 1740             


Gly Gln  Asn Lys Leu His Leu  Arg Ser Val Leu Asn  Glu Phe Asp 
    1745                 1750                 1755             


Ala Ile  Gln Lys Ala Gln Lys  Glu Asn Ser Ser Cys  Thr Asp Lys 
    1760                 1765                 1770             


Arg Glu  Trp Trp Thr Gly Arg  Leu Ala Leu Asp His  Arg Met Glu 
    1775                 1780                 1785             


Val Leu  Ile Ala Ser Leu Glu  Lys Ser Val Leu Gly  Cys Trp Lys 
    1790                 1795                 1800             


Gly Leu  Leu Leu Pro Ser Ser  Glu Glu Pro Gly Pro  Ala Gln Glu 
    1805                 1810                 1815             


Ala Ser  Arg Leu Gln Glu Leu  Leu Gln Asp Cys Gly  Trp Lys Tyr 
    1820                 1825                 1830             


Pro Asp  Arg Thr Leu Leu Lys  Ile Met Leu Ser Gly  Ala Gly Ala 
    1835                 1840                 1845             


Leu Thr  Pro Gln Asp Ile Gln  Ala Leu Ala Tyr Gly  Leu Cys Pro 
    1850                 1855                 1860             


Thr Gln  Pro Glu Arg Ala Gln  Glu Leu Leu Asn Glu  Ala Val Gly 
    1865                 1870                 1875             


Arg Leu  Gln Gly Leu Thr Val  Pro Ser Asn Ser His  Leu Val Leu 
    1880                 1885                 1890             


Val Leu  Asp Lys Asp Leu Gln  Lys Leu Pro Trp Glu  Ser Met Pro 
    1895                 1900                 1905             


Ser Leu  Gln Ala Leu Pro Val  Thr Arg Leu Pro Ser  Phe Arg Phe 
    1910                 1915                 1920             


Leu Leu  Ser Tyr Ser Ile Ile  Lys Glu Tyr Gly Ala  Ser Pro Val 
    1925                 1930                 1935             


Leu Ser  Gln Gly Val Asp Pro  Arg Ser Thr Phe Tyr  Val Leu Asn 
    1940                 1945                 1950             


Pro His  Asn Asn Leu Ser Ser  Thr Glu Glu Gln Phe  Arg Ala Asn 
    1955                 1960                 1965             


Phe Ser  Ser Glu Ala Gly Trp  Arg Gly Val Val Gly  Glu Val Pro 
    1970                 1975                 1980             


Arg Pro  Glu Gln Val Gln Glu  Ala Leu Thr Lys His  Asp Leu Tyr 
    1985                 1990                 1995             


Ile Tyr  Ala Gly His Gly Ala  Gly Ala Arg Phe Leu  Asp Gly Gln 
    2000                 2005                 2010             


Ala Val  Leu Arg Leu Ser Cys  Arg Ala Val Ala Leu  Leu Phe Gly 
    2015                 2020                 2025             


Cys Ser  Ser Ala Ala Leu Ala  Val Arg Gly Asn Leu  Glu Gly Ala 
    2030                 2035                 2040             


Gly Ile  Val Leu Lys Tyr Ile  Met Ala Gly Cys Pro  Leu Phe Leu 
    2045                 2050                 2055             


Gly Asn  Leu Trp Asp Val Thr  Asp Arg Asp Ile Asp  Arg Tyr Thr 
    2060                 2065                 2070             


Glu Ala  Leu Leu Gln Gly Trp  Leu Gly Ala Gly Pro  Gly Ala Pro 
    2075                 2080                 2085             


Leu Leu  Tyr Tyr Val Asn Gln  Ala Arg Gln Ala Pro  Arg Leu Lys 
    2090                 2095                 2100             


Tyr Leu  Ile Gly Ala Ala Pro  Ile Ala Tyr Gly Leu  Pro Val Ser 
    2105                 2110                 2115             


Leu Arg  
    2120 


<210> 12
<211> 6641
<212> DNA
<213> Homo sapiens

<400> 12
ggttacattt tggatcctcg cggagtactg gtcaggcggt taagtcctgt acctaggaaa       60

gagggcgagc tctggggcgc tctccggtgt catgaggagc ttcaaaagag tcaactttgg      120

gactctgcta agcagccaga aggaggctga agagttgctg cccgccttga aggagttcct      180

gtccaaccct ccagctggtt ttcccagcag ccgatctgat gctgagagga gacaagcttg      240

tgatgccatc ctgagggctt gcaaccagca gctgactgct aagctagctt gccctaggca      300

tctggggagc ctgctggagc tggcagagct ggcctgtgat ggctacttag tgtctacccc      360

acagcgtcct cccctctacc tggaacgaat tctctttgtc ttactgcgga atgctgctgc      420

acaaggaagc ccagaggcca cactccgcct tgctcagccc ctccatgcct gcttggtgca      480

gtgctctcgc gaggctgctc cccaggacta tgaggccgtg gctcggggca gcttttctct      540

gctttggaag ggggcagaag ccctgttgga acggcgagct gcatttgcag ctcggctgaa      600

ggccttgagc ttcctagtac tcttggagga tgaaagtacc ccttgtgagg ttcctcactt      660

tgcttctcca acagcctgtc gagcggtagc tgcccatcag ctatttgatg ccagtggcca      720

tggtctaaat gaagcagatg ctgatttcct agatgacctg ctctccaggc acgtgatcag      780

agccttggtg ggtgagagag ggagctcttc tgggcttctt tctccccaga gggccctctg      840

cctcttggag ctcaccttgg aacactgccg tcgcttttgc tggagccgcc accatgacaa      900

agccatcagc gcagtggaga aggctcacag ttacctaagg aacaccaatc tagcccctag      960

ccttcagcta tgtcagctgg gggttaagct gctgcaggtt ggggaggaag gacctcaggc     1020

agtggccaag cttctgatca aggcatcagc tgtcctgagc aagagtatgg aggcaccatc     1080

acccccactt cgggcattgt atgagagctg ccagttcttc ctttcaggcc tggaacgagg     1140

caccaagagg cgctatagac ttgatgccat tctgagcctc tttgcttttc ttggagggta     1200

ctgctctctt ctgcagcagc tgcgggatga tggtgtgtat gggggctcct ccaagcaaca     1260

gcagtctttt cttcagatgt actttcaggg acttcacctc tacactgtgg tggtttatga     1320

ctttgcccaa ggctgtcaga tagttgattt ggctgacctg acccaactag tggacagttg     1380

taaatctacc gttgtctgga tgctggaggc cttagagggc ctgtcgggcc aagagctgac     1440

ggaccacatg gggatgaccg cttcttacac cagtaatttg gcctacagct tctatagtca     1500

caagctctat gccgaggcct gtgccatctc tgagccgctc tgtcagcacc tgggtttggt     1560

gaagccaggc acttatcccg aggtgcctcc tgagaagttg cacaggtgct tccggctaca     1620

agtagagagt ttgaagaaac tgggtaaaca ggcccagggc tgcaagatgg tgattttgtg     1680

gctggcagcc ctgcaaccct gtagccctga acacatggct gagccagtca ctttctgggt     1740

tcgggtcaag atggatgcgg ccagggctgg agacaaggag ctacagctaa agactctgcg     1800

agacagcctc agtggctggg acccggagac cctggccctc ctgctgaggg aggagctgca     1860

ggcctacaag gcggtgcggg ccgacactgg acaggaacgc ttcaacatca tctgtgacct     1920

cctggagctg agccccgagg agacaccagc cggggcctgg gcacgagcca cccacctggt     1980

agaactggct caggtgctct gctaccacga ctttacgcag cagaccaact gctctgctct     2040

ggatgctatc cgggaagccc tgcagcttct ggactctgtg aggcctgagg cccaggccag     2100

agatcagctt ctggacgata aagcacaggc cttgctgtgg ctttacatct gtactctgga     2160

agccaaaatg caggaaggta tcgagcggga tcggagagcc caggcccctg gtaacttgga     2220

ggaatttgaa gtcaatgacc tgaactatga agataaactc caggaagatc gtttcctata     2280

cagtaacatt gccttcaacc tggctgcaga tgctgctcag tccaaatgcc tggaccaagc     2340

cctggccctg tggaaggagc tgcttacaaa ggggcaggcc ccagctgtac ggtgtctcca     2400

gcagacagca gcctcactgc agatcctagc agccctctac cagctggtgg caaagcccat     2460

gcaggctctg gaggtcctcc tgctgctacg gattgtctct gagagactga aggaccactc     2520

gaaggcagct ggctcctcct gccacatcac ccagctcctc ctgaccctcg gctgtcccag     2580

ctatgcccag ttacacctgg aagaggcagc atcgagcctg aagcatctcg atcagactac     2640

tgacacatac ctgctccttt ccctgacctg tgatctgctt cgaagtcaac tctactggac     2700

tcaccagaag gtgaccaagg gtgtctctct gctgctgtct gtgcttcggg atcctgccct     2760

ccagaagtcc tccaaggctt ggtacttgct gcgtgtccag gtcctgcagc tggtggcagc     2820

ttaccttagc ctcccgtcaa acaacctctc acactccctg tgggagcagc tctgtgccca     2880

aggctggcag acacctgaga tagctctcat agactcccat aagctcctcc gaagcatcat     2940

cctcctgctg atgggcagtg acattctctc aactcagaaa gcagctgtgg agacatcgtt     3000

tttggactat ggtgaaaatc tggtacaaaa atggcaggtt ctttcagagg tgctgagctg     3060

ctcagagaag ctggtctgcc acctgggccg cctgggtagt gtgagtgaag ccaaggcctt     3120

ttgcttggag gccctaaaac ttacaacaaa gctgcagata ccacgccagt gtgccctgtt     3180

cctggtgctg aagggcgagc tggagctggc ccgcaatgac attgatctct gtcagtcgga     3240

cctgcagcag gttctgttct tgcttgagtc ttgcacagag tttggtgggg tgactcagca     3300

cctggactct gtgaagaagg tccacctgca gaaggggaag cagcaggccc aggtcccctg     3360

tcctccacag ctcccagagg aggagctctt cctaagaggc cctgctctag agctggtggc     3420

cactgtggcc aaggagcctg gccccatagc accttctaca aactcctccc cagtcttgaa     3480

aaccaagccc cagcccatac ccaacttcct gtcccattca cccacctgtg actgctcgct     3540

ctgcgccagc cctgtcctca cagcagtctg tctgcgctgg gtattggtca cggcaggggt     3600

gaggctggcc atgggccacc aagcccaggg tctggatctg ctgcaggtcg tgctgaaggg     3660

ctgtcctgaa gccgctgagc gcctcaccca agctctccaa gcttccctga atcataaaac     3720

acccccctcc ttggttccaa gcctcttgga tgagatcttg gctcaagcat acacactgtt     3780

ggcactggag ggcctgaacc agccatcaaa cgagagcctg cagaaggttc tacagtcagg     3840

gctgaagttt gtagcagcac ggatacccca cctagagccc tggcgagcca gcctgctctt     3900

gatttgggcc ctcacaaaac taggtggcct cagctgctgt actacccaac tttttgcaag     3960

ctcctggggc tggcagccac cattaataaa aagtgtccct ggctcagagc cctctaagac     4020

tcagggccaa aaacgttctg gacgagggcg ccaaaagtta gcctctgctc ccctgcgcct     4080

caataatacc tctcagaaag gtctggaagg tagaggactg ccctgcacac ctaaaccccc     4140

agaccggatc aggcaagctg gccctcatgt ccccttcacg gtgtttgagg aagtctgccc     4200

tacagagagc aagcctgaag taccccaggc ccccagggta caacagagag tccagacgcg     4260

cctcaaggtg aacttcagtg atgacagtga cttggaagac cctgtctcag ctgaggcctg     4320

gctggcagag gagcctaaga gacggggcac tgcttcccgg ggccgggggc gagcaaggaa     4380

gggcctgagc ctaaagacgg atgccgtggt tgccccaggt agtgcccctg ggaaccctgg     4440

cctgaatggc aggagccgga gggccaagaa ggtggcatca agacattgtg aggagcggcg     4500

tccccagagg gccagtgacc aggccaggcc tggccctgag atcatgagga ccatccctga     4560

ggaagaactg actgacaact ggagaaaaat gagctttgag atcctcaggg gctctgacgg     4620

ggaagactca gcctcaggtg ggaagactcc agctccgggc cctgaggcag cttctggaga     4680

atgggagctg ctgaggctgg attccagcaa gaagaagctg cccagcccat gcccagacaa     4740

ggagagtgac aaggaccttg gtcctcggct ccggctcccc tcagcccccg tagccactgg     4800

tctttctacc ctggactcca tctgtgactc cctgagtgtt gctttccggg gcattagtca     4860

ctgtcctcct agtgggctct atgcccacct ctgccgcttc ctggccttgt gcctgggcca     4920

ccgggatcct tatgccactg ctttccttgt caccgagtct gtctccatca cctgtcgcca     4980

ccagctgctc acccacctcc acagacagct cagcaaggcc cagaagcacc gaggatcact     5040

tgaaatagca gaccagctgc aggggctgag ccttcaggag atgcctggag atgtccccct     5100

ggcccgcatc cagcgcctct tttccttcag ggctttggaa tctggccact tcccccagcc     5160

tgaaaaggag agtttccagg agcgcctggc tctgatcccc agtggggtga ctgtgtgtgt     5220

gttggccctg gccaccctcc agcccggaac cgtgggcaac accctcctgc tgacccggct     5280

ggaaaaggac agtcccccag tcagtgtgca gattcccact ggccagaaca agcttcatct     5340

gcgttcagtc ctgaatgagt ttgatgccat ccagaaggca cagaaagaga acagcagctg     5400

tactgacaag cgagaatggt ggacagggcg gctggcactg gaccacagga tggaggttct     5460

catcgcttcc ctagagaagt ctgtgctggg ctgctggaag gggctgctgc tgccgtccag     5520

tgaggagccc ggccctgccc aggaggcctc ccgcctacag gagctgctac aggactgtgg     5580

ctggaaatat cctgaccgca ctctgctgaa aatcatgctc agtggtgccg gtgccctcac     5640

ccctcaggac attcaggccc tggcctacgg gctgtgccca acccagccag agcgagccca     5700

ggagctcctg aatgaggcag taggacgtct acagggcctg acagtaccaa gcaatagcca     5760

ccttgtcttg gtcctagaca aggacttgca gaagctgccg tgggaaagca tgcccagcct     5820

ccaagcactg cctgtcaccc ggctgccctc cttccgcttc ctactcagct actccatcat     5880

caaagagtat ggggcctcgc cagtgctgag tcaaggggtg gatccacgaa gtaccttcta     5940

tgtcctgaac cctcacaata acctgtcaag cacagaggag caatttcgag ccaatttcag     6000

cagtgaagct ggctggagag gagtggttgg ggaggtgcca agacctgaac aggtgcagga     6060

agccctgaca aagcatgatt tgtatatcta tgcagggcat ggggctggtg cccgcttcct     6120

tgatgggcag gctgtcctgc ggctgagctg tcgggcagtg gccctgctgt ttggctgtag     6180

cagtgcggcc ctggctgtgc gtggaaacct ggagggggct ggcatcgtgc tcaagtacat     6240

catggctggt tgccccttgt ttctgggtaa tctctgggat gtgactgacc gcgacattga     6300

ccgctacacg gaagctctgc tgcaaggctg gcttggagca ggcccagggg ccccccttct     6360

ctactatgta aaccaggccc gccaagctcc ccgactcaag tatcttattg gggctgcacc     6420

tatagcctat ggcttgcctg tctctctgcg gtaaccccat ggagctgtct tattgatgct     6480

agaagcctca taactgttct acctccaagg ttagatttaa tccttaggat aactctttta     6540

aagtgatttt ccccagtgtt ttatatgaaa catttccttt tgatttaacc tcagtataat     6600

aaagatacat catttaaacc ctgaaaaaaa aaaaaaaaaa a                         6641


<210> 13
<211> 707
<212> PRT
<213> Homo sapiens

<400> 13
Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 
    530                 535                 540                 


Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 
545                 550                 555                 560 


Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser 
                565                 570                 575     


Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 
            580                 585                 590         


Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        595                 600                 605             


Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 
    610                 615                 620                 


Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 
625                 630                 635                 640 


Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 
                645                 650                 655     


Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 
            660                 665                 670         


Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 
        675                 680                 685             


Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
    690                 695                 700                 


Pro Glu Asp 
705         


<210> 14
<211> 2387
<212> DNA
<213> Homo sapiens

<400> 14
agacacctct gccctcacca tgagcctctg gcagcccctg gtcctggtgc tcctggtgct       60

gggctgctgc tttgctgccc ccagacagcg ccagtccacc cttgtgctct tccctggaga      120

cctgagaacc aatctcaccg acaggcagct ggcagaggaa tacctgtacc gctatggtta      180

cactcgggtg gcagagatgc gtggagagtc gaaatctctg gggcctgcgc tgctgcttct      240

ccagaagcaa ctgtccctgc ccgagaccgg tgagctggat agcgccacgc tgaaggccat      300

gcgaacccca cggtgcgggg tcccagacct gggcagattc caaacctttg agggcgacct      360

caagtggcac caccacaaca tcacctattg gatccaaaac tactcggaag acttgccgcg      420

ggcggtgatt gacgacgcct ttgcccgcgc cttcgcactg tggagcgcgg tgacgccgct      480

caccttcact cgcgtgtaca gccgggacgc agacatcgtc atccagtttg gtgtcgcgga      540

gcacggagac gggtatccct tcgacgggaa ggacgggctc ctggcacacg cctttcctcc      600

tggccccggc attcagggag acgcccattt cgacgatgac gagttgtggt ccctgggcaa      660

gggcgtcgtg gttccaactc ggtttggaaa cgcagatggc gcggcctgcc acttcccctt      720

catcttcgag ggccgctcct actctgcctg caccaccgac ggtcgctccg acggcttgcc      780

ctggtgcagt accacggcca actacgacac cgacgaccgg tttggcttct gccccagcga      840

gagactctac acccaggacg gcaatgctga tgggaaaccc tgccagtttc cattcatctt      900

ccaaggccaa tcctactccg cctgcaccac ggacggtcgc tccgacggct accgctggtg      960

cgccaccacc gccaactacg accgggacaa gctcttcggc ttctgcccga cccgagctga     1020

ctcgacggtg atggggggca actcggcggg ggagctgtgc gtcttcccct tcactttcct     1080

gggtaaggag tactcgacct gtaccagcga gggccgcgga gatgggcgcc tctggtgcgc     1140

taccacctcg aactttgaca gcgacaagaa gtggggcttc tgcccggacc aaggatacag     1200

tttgttcctc gtggcggcgc atgagttcgg ccacgcgctg ggcttagatc attcctcagt     1260

gccggaggcg ctcatgtacc ctatgtaccg cttcactgag gggcccccct tgcataagga     1320

cgacgtgaat ggcatccggc acctctatgg tcctcgccct gaacctgagc cacggcctcc     1380

aaccaccacc acaccgcagc ccacggctcc cccgacggtc tgccccaccg gaccccccac     1440

tgtccacccc tcagagcgcc ccacagctgg ccccacaggt cccccctcag ctggccccac     1500

aggtcccccc actgctggcc cttctacggc cactactgtg cctttgagtc cggtggacga     1560

tgcctgcaac gtgaacatct tcgacgccat cgcggagatt gggaaccagc tgtatttgtt     1620

caaggatggg aagtactggc gattctctga gggcaggggg agccggccgc agggcccctt     1680

ccttatcgcc gacaagtggc ccgcgctgcc ccgcaagctg gactcggtct ttgaggagcg     1740

gctctccaag aagcttttct tcttctctgg gcgccaggtg tgggtgtaca caggcgcgtc     1800

ggtgctgggc ccgaggcgtc tggacaagct gggcctggga gccgacgtgg cccaggtgac     1860

cggggccctc cggagtggca gggggaagat gctgctgttc agcgggcggc gcctctggag     1920

gttcgacgtg aaggcgcaga tggtggatcc ccggagcgcc agcgaggtgg accggatgtt     1980

ccccggggtg cctttggaca cgcacgacgt cttccagtac cgagagaaag cctatttctg     2040

ccaggaccgc ttctactggc gcgtgagttc ccggagtgag ttgaaccagg tggaccaagt     2100

gggctacgtg acctatgaca tcctgcagtg ccctgaggac tagggctccc gtcctgcttt     2160

ggcagtgcca tgtaaatccc cactgggacc aaccctgggg aaggagccag tttgccggat     2220

acaaactggt attctgttct ggaggaaagg gaggagtgga ggtgggctgg gccctctctt     2280

ctcacctttg ttttttgttg gagtgtttct aataaacttg gattctctaa cctttaaaaa     2340

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   2387


<210> 15
<211> 5058
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (283)..(283)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2674)..(2674)
<223> Any amino acid

<400> 15
Met Gly His Ala Gly Cys Gln Phe Lys Ala Leu Leu Trp Lys Asn Trp 
1               5                   10                  15      


Leu Cys Arg Leu Arg Asn Pro Val Leu Phe Leu Ala Glu Phe Phe Trp 
            20                  25                  30          


Pro Cys Ile Leu Phe Val Ile Leu Thr Val Leu Arg Phe Gln Glu Pro 
        35                  40                  45              


Pro Arg Tyr Arg Asp Ile Cys Tyr Leu Gln Pro Arg Asp Leu Pro Ser 
    50                  55                  60                  


Cys Gly Val Ile Pro Phe Val Gln Ser Leu Leu Cys Asn Thr Gly Ser 
65                  70                  75                  80  


Arg Cys Arg Asn Phe Ser Tyr Glu Gly Ser Met Glu His His Phe Arg 
                85                  90                  95      


Leu Ser Arg Phe Gln Thr Ala Ala Asp Pro Lys Lys Val Asn Asn Leu 
            100                 105                 110         


Ala Phe Leu Lys Glu Ile Gln Asp Leu Ala Glu Glu Ile His Gly Met 
        115                 120                 125             


Met Asp Lys Ala Lys Asn Leu Lys Arg Leu Trp Val Glu Arg Ser Asn 
    130                 135                 140                 


Thr Pro Asp Ser Ser Tyr Gly Ser Ser Phe Phe Thr Met Asp Leu Asn 
145                 150                 155                 160 


Lys Thr Glu Glu Val Ile Leu Lys Leu Glu Ser Leu His Gln Gln Pro 
                165                 170                 175     


His Ile Trp Asp Phe Leu Leu Leu Leu Pro Arg Leu His Thr Ser His 
            180                 185                 190         


Asp His Val Glu Asp Gly Met Asp Val Ala Val Asn Leu Leu Gln Thr 
        195                 200                 205             


Ile Leu Asn Ser Leu Ile Ser Leu Glu Asp Leu Asp Trp Leu Pro Leu 
    210                 215                 220                 


Asn Gln Thr Phe Ser Gln Val Ser Glu Leu Val Leu Asn Val Thr Ile 
225                 230                 235                 240 


Ser Thr Leu Thr Phe Leu Gln Gln His Gly Val Ala Val Thr Glu Pro 
                245                 250                 255     


Val Tyr His Leu Ser Met Gln Asn Ile Val Trp Asp Pro Gln Lys Val 
            260                 265                 270         


Gln Tyr Asp Leu Lys Ser Gln Phe Gly Phe Xaa Asp Leu His Thr Glu 
        275                 280                 285             


Gln Ile Leu Asn Ser Ser Ala Glu Leu Lys Glu Ile Pro Thr Asp Thr 
    290                 295                 300                 


Ser Leu Glu Lys Met Val Cys Ser Val Leu Ser Ser Thr Ser Glu Asp 
305                 310                 315                 320 


Glu Ala Glu Lys Trp Gly His Val Gly Gly Cys His Pro Lys Trp Ser 
                325                 330                 335     


Glu Ala Lys Asn Tyr Leu Val His Ala Val Ser Trp Leu Arg Val Tyr 
            340                 345                 350         


Gln Gln Val Phe Val Gln Trp Gln Gln Gly Ser Leu Leu Gln Lys Thr 
        355                 360                 365             


Leu Thr Gly Met Gly His Ser Leu Glu Ala Leu Arg Asn Gln Phe Glu 
    370                 375                 380                 


Glu Glu Ser Lys Pro Trp Lys Val Val Glu Ala Leu His Thr Ala Leu 
385                 390                 395                 400 


Leu Leu Leu Asn Asp Ser Leu Ser Ala Asp Gly Pro Lys Asp Asn His 
                405                 410                 415     


Thr Phe Pro Lys Ile Leu Gln His Leu Trp Lys Leu Gln Ser Leu Leu 
            420                 425                 430         


Gln Asn Leu Pro Gln Trp Pro Ala Leu Lys Arg Phe Leu Gln Leu Asp 
        435                 440                 445             


Gly Ala Leu Arg Asn Ala Ile Ala Gln Asn Leu His Phe Val Gln Glu 
    450                 455                 460                 


Val Leu Ile Cys Leu Glu Thr Ser Ala Asn Asp Phe Lys Trp Phe Glu 
465                 470                 475                 480 


Leu Asn Gln Leu Lys Leu Glu Lys Asp Val Phe Phe Trp Glu Leu Lys 
                485                 490                 495     


Gln Met Leu Ala Lys Asn Ala Val Cys Pro Asn Gly Arg Phe Ser Glu 
            500                 505                 510         


Lys Glu Val Phe Leu Pro Pro Gly Asn Ser Ser Ile Trp Gly Gly Leu 
        515                 520                 525             


Gln Gly Leu Leu Cys Tyr Cys Asn Ser Ser Glu Thr Ser Val Leu Asn 
    530                 535                 540                 


Lys Leu Leu Gly Ser Val Glu Asp Ala Asp Arg Ile Leu Gln Glu Val 
545                 550                 555                 560 


Ile Thr Trp His Lys Asn Met Ser Val Leu Ile Pro Glu Glu Tyr Leu 
                565                 570                 575     


Asp Trp Gln Glu Leu Glu Met Gln Leu Ser Glu Ala Ser Leu Ser Cys 
            580                 585                 590         


Thr Arg Leu Phe Leu Leu Leu Gly Ala Asp Pro Ser Pro Glu Asn Asp 
        595                 600                 605             


Val Phe Ser Ser Asp Cys Lys His Gln Leu Val Ser Thr Val Ile Phe 
    610                 615                 620                 


His Thr Leu Glu Lys Thr Gln Phe Phe Leu Glu Gln Ala Tyr Tyr Trp 
625                 630                 635                 640 


Lys Ala Phe Lys Lys Phe Ile Arg Lys Thr Cys Glu Val Ala Gln Tyr 
                645                 650                 655     


Val Asn Met Gln Glu Ser Phe Gln Asn Arg Leu Leu Ala Phe Pro Glu 
            660                 665                 670         


Glu Ser Pro Cys Phe Glu Glu Asn Met Asp Trp Lys Met Ile Ser Asp 
        675                 680                 685             


Asn Tyr Phe Gln Phe Leu Asn Asn Leu Leu Lys Ser Pro Thr Ala Ser 
    690                 695                 700                 


Ile Ser Arg Ala Leu Asn Phe Thr Lys His Leu Leu Met Met Glu Lys 
705                 710                 715                 720 


Lys Leu His Thr Leu Glu Asp Glu Gln Met Asn Phe Leu Leu Ser Phe 
                725                 730                 735     


Val Glu Phe Phe Glu Lys Leu Leu Leu Pro Asn Leu Phe Asp Ser Ser 
            740                 745                 750         


Ile Val Pro Ser Phe His Ser Leu Pro Ser Leu Thr Glu Asp Ile Leu 
        755                 760                 765             


Asn Ile Ser Ser Leu Trp Thr Asn His Leu Lys Ser Leu Lys Arg Asp 
    770                 775                 780                 


Pro Ser Ala Thr Asp Ala Gln Lys Leu Leu Glu Phe Gly Asn Glu Val 
785                 790                 795                 800 


Ile Trp Lys Met Gln Thr Leu Gly Ser His Trp Ile Arg Lys Glu Pro 
                805                 810                 815     


Lys Asn Leu Leu Arg Phe Ile Glu Leu Ile Leu Phe Glu Ile Asn Pro 
            820                 825                 830         


Lys Leu Leu Glu Leu Trp Ala Tyr Gly Ile Ser Lys Gly Lys Arg Ala 
        835                 840                 845             


Lys Leu Glu Asn Phe Phe Thr Leu Leu Asn Phe Ser Val Pro Glu Asn 
    850                 855                 860                 


Glu Ile Leu Ser Thr Ser Phe Asn Phe Ser Gln Leu Phe His Ser Asp 
865                 870                 875                 880 


Trp Pro Lys Ser Pro Ala Met Asn Ile Asp Phe Val Arg Leu Ser Glu 
                885                 890                 895     


Ala Ile Ile Thr Ser Leu His Glu Phe Gly Phe Leu Glu Gln Glu Gln 
            900                 905                 910         


Ile Ser Glu Ala Leu Asn Thr Val Tyr Ala Ile Arg Asn Ala Ser Asp 
        915                 920                 925             


Leu Phe Ser Ala Leu Ser Glu Pro Gln Lys Gln Glu Val Asp Lys Ile 
    930                 935                 940                 


Leu Thr His Ile His Leu Asn Val Phe Gln Asp Lys Asp Ser Ala Leu 
945                 950                 955                 960 


Leu Leu Gln Ile Tyr Ser Ser Phe Tyr Arg Tyr Ile Tyr Glu Leu Leu 
                965                 970                 975     


Asn Ile Gln Ser Arg Gly Ser Ser Leu Thr Phe Leu Thr Gln Ile Ser 
            980                 985                 990         


Lys His Ile Leu Asp Ile Ile Lys  Gln Phe Asn Phe Gln  Asn Ile Ser 
        995                 1000                 1005             


Lys Ala  Phe Ala Phe Leu Phe  Lys Thr Ala Glu Val  Leu Gly Gly 
    1010                 1015                 1020             


Ile Ser  Asn Val Ser Tyr Cys  Gln Gln Leu Leu Ser  Ile Phe Asn 
    1025                 1030                 1035             


Phe Leu  Glu Leu Gln Ala Gln  Ser Phe Met Ser Thr  Glu Gly Gln 
    1040                 1045                 1050             


Glu Leu  Glu Val Ile His Thr  Thr Leu Thr Gly Leu  Lys Gln Leu 
    1055                 1060                 1065             


Leu Ile  Ile Asp Glu Asp Phe  Arg Ile Ser Leu Phe  Gln Tyr Met 
    1070                 1075                 1080             


Ser Gln  Phe Phe Asn Ser Ser  Val Glu Asp Leu Leu  Asp Asn Lys 
    1085                 1090                 1095             


Cys Leu  Ile Ser Asp Asn Lys  His Ile Ser Ser Val  Asn Tyr Ser 
    1100                 1105                 1110             


Thr Ser  Glu Glu Ser Ser Phe  Val Phe Pro Leu Ala  Gln Ile Phe 
    1115                 1120                 1125             


Ser Asn  Leu Ser Ala Asn Val  Ser Val Phe Asn Lys  Phe Met Ser 
    1130                 1135                 1140             


Ile His  Cys Thr Val Ser Trp  Leu Gln Met Trp Thr  Glu Ile Trp 
    1145                 1150                 1155             


Glu Thr  Ile Ser Gln Leu Phe  Lys Phe Asp Met Asn  Val Phe Thr 
    1160                 1165                 1170             


Ser Leu  His His Gly Phe Thr  Gln Leu Leu Asp Glu  Leu Glu Asp 
    1175                 1180                 1185             


Asp Val  Lys Val Ser Lys Ser  Cys Gln Gly Ile Leu  Pro Thr His 
    1190                 1195                 1200             


Asn Val  Ala Arg Leu Ile Leu  Asn Leu Phe Lys Asn  Val Thr Gln 
    1205                 1210                 1215             


Ala Asn  Asp Phe His Asn Trp  Glu Asp Phe Leu Asp  Leu Arg Asp 
    1220                 1225                 1230             


Phe Leu  Val Ala Leu Gly Asn  Ala Leu Val Ser Val  Lys Lys Leu 
    1235                 1240                 1245             


Asn Leu  Glu Gln Val Glu Lys  Ser Leu Phe Thr Met  Glu Ala Ala 
    1250                 1255                 1260             


Leu His  Gln Leu Lys Thr Phe  Pro Phe Asn Glu Ser  Thr Ser Arg 
    1265                 1270                 1275             


Glu Phe  Leu Asn Ser Leu Leu  Glu Val Phe Ile Glu  Phe Ser Ser 
    1280                 1285                 1290             


Thr Ser  Glu Tyr Ile Val Arg  Asn Leu Asp Ser Ile  Asn Asp Phe 
    1295                 1300                 1305             


Leu Ser  Asn Asn Leu Thr Asn  Tyr Gly Glu Lys Phe  Glu Asn Ile 
    1310                 1315                 1320             


Ile Thr  Glu Leu Arg Glu Ala  Ile Val Phe Leu Arg  Asn Val Ser 
    1325                 1330                 1335             


His Asp  Arg Asp Leu Phe Ser  Cys Ala Asp Ile Phe  Gln Asn Val 
    1340                 1345                 1350             


Thr Glu  Cys Ile Leu Glu Asp  Gly Phe Leu Tyr Val  Asn Thr Ser 
    1355                 1360                 1365             


Gln Arg  Met Leu Arg Ile Leu  Asp Thr Leu Asn Ser  Thr Phe Ser 
    1370                 1375                 1380             


Ser Glu  Asn Thr Ile Ser Ser  Leu Lys Gly Cys Ile  Val Trp Leu 
    1385                 1390                 1395             


Asp Val  Ile Asn His Leu Tyr  Leu Leu Ser Asn Ser  Ser Phe Ser 
    1400                 1405                 1410             


Gln Gly  Arg Leu Gln Asn Ile  Leu Gly Asn Phe Arg  Asp Ile Glu 
    1415                 1420                 1425             


Asn Lys  Met Asn Ser Ile Leu  Lys Ile Val Thr Trp  Val Leu Asn 
    1430                 1435                 1440             


Ile Lys  Lys Pro Leu Cys Ser  Ser Asn Gly Ser His  Ile Asn Cys 
    1445                 1450                 1455             


Val Asn  Ile Tyr Leu Lys Asp  Val Thr Asp Phe Leu  Asn Ile Val 
    1460                 1465                 1470             


Leu Thr  Thr Val Phe Glu Lys  Glu Lys Lys Pro Lys  Phe Glu Ile 
    1475                 1480                 1485             


Leu Leu  Ala Leu Leu Asn Asp  Ser Thr Lys Gln Val  Arg Met Ser 
    1490                 1495                 1500             


Ile Asn  Asn Leu Thr Thr Asp  Phe Asp Phe Ala Ser  Gln Ser Asn 
    1505                 1510                 1515             


Trp Arg  Tyr Phe Thr Glu Leu  Ile Leu Arg Pro Ile  Glu Met Ser 
    1520                 1525                 1530             


Asp Glu  Ile Pro Asn Gln Phe  Gln Asn Ile Trp Leu  His Leu Ile 
    1535                 1540                 1545             


Thr Leu  Gly Lys Glu Phe Gln  Lys Leu Val Lys Gly  Ile Tyr Phe 
    1550                 1555                 1560             


Asn Ile  Leu Glu Asn Asn Ser  Ser Ser Lys Thr Glu  Asn Leu Leu 
    1565                 1570                 1575             


Asn Ile  Phe Ala Thr Ser Pro  Lys Glu Lys Asp Val  Asn Ser Val 
    1580                 1585                 1590             


Gly Asn  Ser Ile Tyr His Leu  Ala Ser Tyr Leu Ala  Phe Ser Leu 
    1595                 1600                 1605             


Ser His  Asp Leu Gln Asn Ser  Pro Lys Ile Ile Ile  Ser Pro Glu 
    1610                 1615                 1620             


Ile Met  Lys Ala Thr Gly Leu  Gly Ile Gln Leu Ile  Arg Asp Val 
    1625                 1630                 1635             


Phe Asn  Ser Leu Met Pro Val  Val His His Thr Ser  Pro Gln Asn 
    1640                 1645                 1650             


Ala Gly  Tyr Met Gln Ala Leu  Lys Lys Val Thr Ser  Val Met Arg 
    1655                 1660                 1665             


Thr Leu  Lys Lys Ala Asp Ile  Asp Leu Leu Val Asp  Gln Leu Glu 
    1670                 1675                 1680             


Gln Val  Ser Val Asn Leu Met  Asp Phe Phe Lys Asn  Ile Ser Ser 
    1685                 1690                 1695             


Val Gly  Thr Gly Asn Leu Val  Val Asn Leu Leu Val  Gly Leu Met 
    1700                 1705                 1710             


Glu Lys  Phe Ala Asp Ser Ser  His Ser Trp Asn Val  Asn His Leu 
    1715                 1720                 1725             


Leu Gln  Leu Ser Arg Leu Phe  Pro Lys Asp Val Val  Asp Ala Val 
    1730                 1735                 1740             


Ile Asp  Val Tyr Tyr Val Leu  Pro His Ala Val Arg  Leu Leu Gln 
    1745                 1750                 1755             


Gly Val  Pro Gly Lys Asn Ile  Thr Glu Gly Leu Lys  Asp Val Tyr 
    1760                 1765                 1770             


Ser Phe  Thr Leu Leu His Gly  Ile Thr Ile Ser Asn  Ile Thr Lys 
    1775                 1780                 1785             


Glu Asp  Phe Ala Ile Val Ile  Lys Ile Leu Leu Asp  Thr Ile Glu 
    1790                 1795                 1800             


Leu Val  Ser Asp Lys Pro Asp  Ile Ile Ser Glu Ala  Leu Ala Cys 
    1805                 1810                 1815             


Phe Pro  Val Val Trp Cys Trp  Asn His Thr Asn Ser  Gly Phe Arg 
    1820                 1825                 1830             


Gln Asn  Ser Lys Ile Asp Pro  Cys Asn Val His Gly  Leu Met Ser 
    1835                 1840                 1845             


Ser Ser  Phe Tyr Gly Lys Val  Ala Ser Ile Leu Asp  His Phe His 
    1850                 1855                 1860             


Leu Ser  Pro Gln Gly Glu Asp  Ser Pro Cys Ser Asn  Glu Ser Ser 
    1865                 1870                 1875             


Arg Met  Glu Ile Thr Arg Lys  Val Val Cys Ile Ile  His Glu Leu 
    1880                 1885                 1890             


Val Asp  Trp Asn Ser Ile Leu  Leu Glu Leu Ser Glu  Val Phe His 
    1895                 1900                 1905             


Val Asn  Ile Ser Leu Val Lys  Thr Val Gln Lys Phe  Trp His Lys 
    1910                 1915                 1920             


Ile Leu  Pro Phe Val Pro Pro  Ser Ile Asn Gln Thr  Arg Asp Ser 
    1925                 1930                 1935             


Ile Ser  Glu Leu Cys Pro Ser  Gly Ser Ile Lys Gln  Val Ala Leu 
    1940                 1945                 1950             


Gln Ile  Ile Glu Lys Leu Lys  Asn Val Asn Phe Thr  Lys Val Thr 
    1955                 1960                 1965             


Ser Gly  Glu Asn Ile Leu Asp  Lys Leu Ser Ser Leu  Asn Lys Ile 
    1970                 1975                 1980             


Leu Asn  Ile Asn Glu Asp Thr  Glu Thr Ser Val Gln  Asn Ile Ile 
    1985                 1990                 1995             


Ser Ser  Asn Leu Glu Arg Thr  Val Gln Leu Ile Ser  Glu Asp Trp 
    2000                 2005                 2010             


Ser Leu  Glu Lys Ser Thr His  Asn Leu Leu Ser Leu  Phe Met Met 
    2015                 2020                 2025             


Leu Gln  Asn Ala Asn Val Thr  Gly Ser Ser Leu Glu  Ala Leu Ser 
    2030                 2035                 2040             


Ser Phe  Ile Glu Lys Ser Glu  Thr Pro Tyr Asn Phe  Glu Glu Leu 
    2045                 2050                 2055             


Trp Pro  Lys Phe Gln Gln Ile  Met Lys Asp Leu Thr  Gln Asp Phe 
    2060                 2065                 2070             


Arg Ile  Arg His Leu Leu Ser  Glu Met Asn Lys Gly  Ile Lys Ser 
    2075                 2080                 2085             


Ile Asn  Ser Met Ala Leu Gln  Lys Ile Thr Leu Gln  Phe Ala His 
    2090                 2095                 2100             


Phe Leu  Glu Ile Leu Asp Ser  Pro Ser Leu Lys Thr  Leu Glu Ile 
    2105                 2110                 2115             


Ile Glu  Asp Phe Leu Leu Val  Thr Lys Asn Trp Leu  Gln Glu Tyr 
    2120                 2125                 2130             


Ala Asn  Glu Asp Tyr Ser Arg  Met Ile Glu Thr Leu  Phe Ile Pro 
    2135                 2140                 2145             


Val Thr  Asn Glu Ser Ser Thr  Glu Asp Ile Ala Leu  Leu Ala Lys 
    2150                 2155                 2160             


Ala Ile  Ala Thr Phe Trp Gly  Ser Leu Lys Asn Ile  Ser Arg Ala 
    2165                 2170                 2175             


Gly Asn  Phe Asp Val Ala Phe  Leu Thr His Leu Leu  Asn Gln Glu 
    2180                 2185                 2190             


Gln Leu  Thr Asn Phe Ser Val  Val Gln Leu Leu Phe  Glu Asn Ile 
    2195                 2200                 2205             


Leu Ile  Asn Leu Ile Asn Asn  Leu Ala Gly Asn Ser  Gln Glu Ala 
    2210                 2215                 2220             


Ala Trp  Asn Leu Asn Asp Thr  Asp Leu Gln Ile Met  Asn Phe Ile 
    2225                 2230                 2235             


Asn Leu  Ile Leu Asn His Met  Gln Ser Glu Thr Ser  Arg Lys Thr 
    2240                 2245                 2250             


Val Leu  Ser Leu Arg Ser Ile  Val Asp Phe Thr Glu  Gln Phe Leu 
    2255                 2260                 2265             


Lys Thr  Phe Phe Ser Leu Phe  Leu Lys Glu Asp Ser  Glu Asn Lys 
    2270                 2275                 2280             


Ile Ser  Leu Leu Leu Lys Tyr  Phe His Lys Asp Val  Ile Ala Glu 
    2285                 2290                 2295             


Met Ser  Phe Val Pro Lys Asp  Lys Ile Leu Glu Ile  Leu Lys Leu 
    2300                 2305                 2310             


Asp Gln  Phe Leu Thr Leu Met  Ile Gln Asp Arg Leu  Met Asn Ile 
    2315                 2320                 2325             


Phe Ser  Ser Leu Lys Glu Thr  Ile Tyr His Leu Met  Lys Ser Ser 
    2330                 2335                 2340             


Phe Ile  Leu Asp Asn Gly Glu  Phe Tyr Phe Asp Thr  His Gln Gly 
    2345                 2350                 2355             


Leu Lys  Phe Met Gln Asp Leu  Phe Asn Ala Leu Leu  Arg Glu Thr 
    2360                 2365                 2370             


Ser Met  Lys Asn Lys Thr Glu  Asn Asn Ile Asp Phe  Phe Thr Val 
    2375                 2380                 2385             


Val Ser  Gln Leu Phe Phe His  Val Asn Lys Ser Glu  Asp Leu Phe 
    2390                 2395                 2400             


Lys Leu  Asn Gln Asp Leu Gly  Ser Ala Leu His Leu  Val Arg Glu 
    2405                 2410                 2415             


Cys Ser  Thr Glu Met Ala Arg  Leu Leu Asp Thr Ile  Leu His Ser 
    2420                 2425                 2430             


Pro Asn  Lys Asp Phe Tyr Ala  Leu Tyr Pro Thr Leu  Gln Glu Val 
    2435                 2440                 2445             


Ile Leu  Ala Asn Leu Thr Asp  Leu Leu Phe Phe Ile  Asn Asn Ser 
    2450                 2455                 2460             


Phe Pro  Leu Arg Asn Arg Ala  Thr Leu Glu Ile Thr  Lys Arg Leu 
    2465                 2470                 2475             


Val Gly  Ala Ile Ser Arg Ala  Ser Glu Glu Ser His  Val Leu Lys 
    2480                 2485                 2490             


Pro Leu  Leu Glu Met Ser Gly  Thr Leu Val Met Leu  Leu Asn Asp 
    2495                 2500                 2505             


Ser Ala  Asp Leu Arg Asp Leu  Ala Thr Ser Met Asp  Ser Ile Val 
    2510                 2515                 2520             


Lys Leu  Leu Lys Leu Val Lys  Lys Val Ser Gly Lys  Met Ser Thr 
    2525                 2530                 2535             


Val Phe  Lys Thr His Phe Ile  Ser Asn Thr Lys Asp  Ser Val Lys 
    2540                 2545                 2550             


Phe Phe  Asp Thr Leu Tyr Ser  Ile Met Gln Gln Ser  Val Gln Asn 
    2555                 2560                 2565             


Leu Val  Lys Glu Ile Ala Thr  Leu Lys Lys Ile Asp  His Phe Thr 
    2570                 2575                 2580             


Phe Glu  Lys Ile Asn Asp Leu  Leu Val Pro Phe Leu  Asp Leu Ala 
    2585                 2590                 2595             


Phe Glu  Met Ile Gly Val Glu  Pro Tyr Ile Ser Ser  Asn Ser Asp 
    2600                 2605                 2610             


Ile Phe  Ser Met Ser Pro Ser  Ile Leu Ser Tyr Met  Asn Gln Ser 
    2615                 2620                 2625             


Lys Asp  Phe Ser Asp Ile Leu  Glu Glu Ile Ala Glu  Phe Leu Thr 
    2630                 2635                 2640             


Ser Val  Lys Met Asn Leu Glu  Asp Met Arg Ser Leu  Ala Val Ala 
    2645                 2650                 2655             


Phe Asn  Asn Glu Thr Gln Thr  Phe Ser Met Asp Ser  Val Asn Leu 
    2660                 2665                 2670             


Xaa Glu  Glu Ile Leu Gly Cys  Leu Val Pro Ile Asn  Asn Ile Thr 
    2675                 2680                 2685             


Asn Gln  Met Asp Phe Leu Tyr  Pro Asn Pro Ile Ser  Thr His Ser 
    2690                 2695                 2700             


Gly Pro  Gln Asp Ile Lys Trp  Glu Ile Ile His Glu  Val Ile Leu 
    2705                 2710                 2715             


Phe Leu  Asp Lys Ile Leu Ser  Gln Asn Ser Thr Glu  Ile Gly Ser 
    2720                 2725                 2730             


Phe Leu  Lys Met Val Ile Cys  Leu Thr Leu Glu Ala  Leu Trp Lys 
    2735                 2740                 2745             


Asn Leu  Lys Lys Asp Asn Trp  Asn Val Ser Asn Val  Leu Met Thr 
    2750                 2755                 2760             


Phe Thr  Gln His Pro Asn Asn  Leu Leu Lys Thr Ile  Glu Thr Val 
    2765                 2770                 2775             


Leu Glu  Ala Ser Ser Gly Ile  Lys Ser Asp Tyr Glu  Gly Asp Leu 
    2780                 2785                 2790             


Asn Lys  Ser Leu Tyr Phe Asp  Thr Pro Leu Ser Gln  Asn Ile Thr 
    2795                 2800                 2805             


His His  Gln Leu Glu Lys Ala  Ile His Asn Val Leu  Ser Arg Ile 
    2810                 2815                 2820             


Ala Leu  Trp Arg Lys Gly Leu  Arg Phe Asn Asn Ser  Glu Trp Ile 
    2825                 2830                 2835             


Thr Ser  Thr Arg Thr Leu Phe  Gln Pro Leu Phe Glu  Ile Phe Ile 
    2840                 2845                 2850             


Lys Ala  Thr Thr Gly Lys Asn  Val Thr Ser Glu Lys  Glu Glu Arg 
    2855                 2860                 2865             


Thr Glu  Lys Glu Met Ile Asp  Phe Pro Tyr Ser Phe  Lys Pro Phe 
    2870                 2875                 2880             


Phe Cys  Leu Glu Lys Tyr Leu  Gly Gly Leu Phe Val  Leu Thr Lys 
    2885                 2890                 2895             


Tyr Trp  Gln Gln Ile Pro Leu  Thr Asp Gln Ser Val  Val Glu Ile 
    2900                 2905                 2910             


Cys Glu  Val Phe Gln Gln Thr  Val Lys Pro Ser Glu  Ala Met Glu 
    2915                 2920                 2925             


Met Leu  Gln Lys Val Lys Met  Met Val Val Arg Val  Leu Thr Ile 
    2930                 2935                 2940             


Val Ala  Glu Asn Pro Ser Trp  Thr Lys Asp Ile Leu  Cys Ala Thr 
    2945                 2950                 2955             


Leu Ser  Cys Lys Gln Asn Gly  Ile Arg His Leu Ile  Leu Ser Ala 
    2960                 2965                 2970             


Ile Gln  Gly Val Thr Leu Ala  Gln Asp His Phe Gln  Glu Ile Glu 
    2975                 2980                 2985             


Lys Ile  Trp Ser Ser Pro Asn  Gln Leu Asn Cys Glu  Ser Leu Ser 
    2990                 2995                 3000             


Lys Asn  Leu Ser Ser Thr Leu  Glu Ser Phe Lys Ser  Ser Leu Glu 
    3005                 3010                 3015             


Asn Ala  Thr Gly Gln Asp Cys  Thr Ser Gln Pro Arg  Leu Glu Thr 
    3020                 3025                 3030             


Val Gln  Gln His Leu Tyr Met  Leu Ala Lys Ser Leu  Glu Glu Thr 
    3035                 3040                 3045             


Trp Ser  Ser Gly Asn Pro Ile  Met Thr Phe Leu Ser  Asn Phe Thr 
    3050                 3055                 3060             


Val Thr  Glu Asp Val Lys Ile  Lys Asp Leu Met Lys  Asn Ile Thr 
    3065                 3070                 3075             


Lys Leu  Thr Glu Glu Leu Arg  Ser Ser Ile Gln Ile  Ser Asn Glu 
    3080                 3085                 3090             


Thr Ile  His Ser Ile Leu Glu  Ala Asn Ile Ser His  Ser Lys Val 
    3095                 3100                 3105             


Leu Phe  Ser Ala Leu Thr Val  Ala Leu Ser Gly Lys  Cys Asp Gln 
    3110                 3115                 3120             


Glu Ile  Leu His Leu Leu Leu  Thr Phe Pro Lys Gly  Glu Lys Ser 
    3125                 3130                 3135             


Trp Ile  Ala Ala Glu Glu Leu  Cys Ser Leu Pro Gly  Ser Lys Val 
    3140                 3145                 3150             


Tyr Ser  Leu Ile Val Leu Leu  Ser Arg Asn Leu Asp  Val Arg Ala 
    3155                 3160                 3165             


Phe Ile  Tyr Lys Thr Leu Met  Pro Ser Glu Ala Asn  Gly Leu Leu 
    3170                 3175                 3180             


Asn Ser  Leu Leu Asp Ile Val  Ser Ser Leu Ser Ala  Leu Leu Ala 
    3185                 3190                 3195             


Lys Ala  Gln His Val Phe Glu  Tyr Leu Pro Glu Phe  Leu His Thr 
    3200                 3205                 3210             


Phe Lys  Ile Thr Ala Leu Leu  Glu Thr Leu Asp Phe  Gln Gln Val 
    3215                 3220                 3225             


Ser Gln  Asn Val Gln Ala Arg  Ser Ser Ala Phe Gly  Ser Phe Gln 
    3230                 3235                 3240             


Phe Val  Met Lys Met Val Cys  Lys Asp Gln Ala Ser  Phe Leu Ser 
    3245                 3250                 3255             


Asp Ser  Asn Met Phe Ile Asn  Leu Pro Arg Val Lys  Glu Leu Leu 
    3260                 3265                 3270             


Glu Asp  Asp Lys Glu Lys Phe  Asn Ile Pro Glu Asp  Ser Thr Pro 
    3275                 3280                 3285             


Phe Cys  Leu Lys Leu Tyr Gln  Glu Ile Leu Gln Leu  Pro Asn Gly 
    3290                 3295                 3300             


Ala Leu  Val Trp Thr Phe Leu  Lys Pro Ile Leu His  Gly Lys Ile 
    3305                 3310                 3315             


Leu Tyr  Thr Pro Asn Thr Pro  Glu Ile Asn Lys Val  Ile Gln Lys 
    3320                 3325                 3330             


Ala Asn  Tyr Thr Phe Tyr Ile  Val Asp Lys Leu Lys  Thr Leu Ser 
    3335                 3340                 3345             


Glu Thr  Leu Leu Glu Met Ser  Ser Leu Phe Gln Arg  Ser Gly Ser 
    3350                 3355                 3360             


Gly Gln  Met Phe Asn Gln Leu  Gln Glu Ala Leu Arg  Asn Lys Phe 
    3365                 3370                 3375             


Val Arg  Asn Phe Val Glu Asn  Gln Leu His Ile Asp  Val Asp Lys 
    3380                 3385                 3390             


Leu Thr  Glu Lys Leu Gln Thr  Tyr Gly Gly Leu Leu  Asp Glu Met 
    3395                 3400                 3405             


Phe Asn  His Ala Gly Ala Gly  Arg Phe Arg Phe Leu  Gly Ser Ile 
    3410                 3415                 3420             


Leu Val  Asn Leu Ser Ser Cys  Val Ala Leu Asn Arg  Phe Gln Ala 
    3425                 3430                 3435             


Leu Gln  Ser Val Asp Ile Leu  Glu Thr Lys Ala His  Glu Leu Leu 
    3440                 3445                 3450             


Gln Gln  Asn Ser Phe Leu Ala  Ser Ile Ile Phe Ser  Asn Ser Leu 
    3455                 3460                 3465             


Phe Asp  Lys Asn Phe Arg Ser  Glu Ser Val Lys Leu  Pro Pro His 
    3470                 3475                 3480             


Val Ser  Tyr Thr Ile Arg Thr  Asn Val Leu Tyr Ser  Val Arg Thr 
    3485                 3490                 3495             


Asp Val  Val Lys Asn Pro Ser  Trp Lys Phe His Pro  Gln Asn Leu 
    3500                 3505                 3510             


Pro Ala  Asp Gly Phe Lys Tyr  Asn Tyr Val Phe Ala  Pro Leu Gln 
    3515                 3520                 3525             


Asp Met  Ile Glu Arg Ala Ile  Ile Leu Val Gln Thr  Gly Gln Glu 
    3530                 3535                 3540             


Ala Leu  Glu Pro Ala Ala Gln  Thr Gln Ala Ala Pro  Tyr Pro Cys 
    3545                 3550                 3555             


His Thr  Ser Asp Leu Phe Leu  Asn Asn Val Gly Phe  Phe Phe Pro 
    3560                 3565                 3570             


Leu Ile  Met Met Leu Thr Trp  Met Val Ser Val Ala  Ser Met Val 
    3575                 3580                 3585             


Arg Lys  Leu Val Tyr Glu Gln  Glu Ile Gln Ile Glu  Glu Tyr Met 
    3590                 3595                 3600             


Arg Met  Met Gly Val His Pro  Val Ile His Phe Leu  Ala Trp Phe 
    3605                 3610                 3615             


Leu Glu  Asn Met Ala Val Leu  Thr Ile Ser Ser Ala  Thr Leu Ala 
    3620                 3625                 3630             


Ile Val  Leu Lys Thr Ser Gly  Ile Phe Ala His Ser  Asn Thr Phe 
    3635                 3640                 3645             


Ile Val  Phe Leu Phe Leu Leu  Asp Phe Gly Met Ser  Val Val Met 
    3650                 3655                 3660             


Leu Ser  Tyr Leu Leu Ser Ala  Phe Phe Ser Gln Ala  Asn Thr Ala 
    3665                 3670                 3675             


Ala Leu  Cys Thr Ser Leu Val  Tyr Met Ile Ser Phe  Leu Pro Tyr 
    3680                 3685                 3690             


Ile Val  Leu Leu Val Leu His  Asn Gln Leu Ser Phe  Val Asn Gln 
    3695                 3700                 3705             


Thr Phe  Leu Cys Leu Leu Ser  Thr Thr Ala Phe Gly  Gln Gly Val 
    3710                 3715                 3720             


Phe Phe  Ile Thr Phe Leu Glu  Gly Gln Glu Thr Gly  Ile Gln Trp 
    3725                 3730                 3735             


Asn Asn  Met Tyr Gln Ala Leu  Glu Gln Gly Gly Met  Thr Phe Gly 
    3740                 3745                 3750             


Trp Val  Cys Trp Met Ile Leu  Phe Asp Ser Ser Leu  Tyr Phe Leu 
    3755                 3760                 3765             


Cys Gly  Trp Tyr Leu Ser Asn  Leu Ile Pro Gly Thr  Phe Gly Leu 
    3770                 3775                 3780             


Arg Lys  Pro Trp Tyr Phe Pro  Phe Thr Ala Ser Tyr  Trp Lys Ser 
    3785                 3790                 3795             


Val Gly  Phe Leu Val Glu Lys  Arg Gln Tyr Phe Leu  Ser Ser Ser 
    3800                 3805                 3810             


Leu Phe  Phe Phe Asn Glu Asn  Phe Asp Asn Lys Gly  Ser Ser Leu 
    3815                 3820                 3825             


Gln Asn  Arg Glu Gly Glu Leu  Glu Gly Ser Ala Pro  Gly Val Thr 
    3830                 3835                 3840             


Leu Val  Ser Val Thr Lys Glu  Tyr Glu Gly His Lys  Ala Val Val 
    3845                 3850                 3855             


Gln Asp  Leu Ser Leu Thr Phe  Tyr Arg Asp Gln Ile  Thr Ala Leu 
    3860                 3865                 3870             


Leu Gly  Thr Asn Gly Ala Gly  Lys Thr Thr Ile Ile  Ser Met Leu 
    3875                 3880                 3885             


Thr Gly  Leu His Pro Pro Thr  Ser Gly Thr Ile Ile  Ile Asn Gly 
    3890                 3895                 3900             


Lys Asn  Leu Gln Thr Asp Leu  Ser Arg Val Arg Met  Glu Leu Gly 
    3905                 3910                 3915             


Val Cys  Pro Gln Gln Asp Ile  Leu Leu Asp Asn Leu  Thr Val Arg 
    3920                 3925                 3930             


Glu His  Leu Leu Leu Phe Ala  Ser Ile Lys Ala Pro  Gln Trp Thr 
    3935                 3940                 3945             


Lys Lys  Glu Leu His Gln Gln  Val Asn Gln Thr Leu  Gln Asp Val 
    3950                 3955                 3960             


Asp Leu  Thr Gln His Gln His  Lys Gln Thr Arg Ala  Leu Ser Gly 
    3965                 3970                 3975             


Gly Leu  Lys Arg Lys Leu Ser  Leu Gly Ile Ala Phe  Met Gly Met 
    3980                 3985                 3990             


Ser Arg  Thr Val Val Leu Asp  Glu Pro Thr Ser Gly  Val Asp Pro 
    3995                 4000                 4005             


Cys Ser  Arg His Ser Leu Trp  Asp Ile Leu Leu Lys  Tyr Arg Glu 
    4010                 4015                 4020             


Gly Arg  Thr Ile Ile Phe Thr  Thr His His Leu Asp  Glu Ala Glu 
    4025                 4030                 4035             


Ala Leu  Ser Asp Arg Val Ala  Val Leu Gln His Gly  Arg Leu Arg 
    4040                 4045                 4050             


Cys Cys  Gly Pro Pro Phe Cys  Leu Lys Glu Ala Tyr  Gly Gln Gly 
    4055                 4060                 4065             


Leu Arg  Leu Thr Leu Thr Arg  Gln Pro Ser Val Leu  Glu Ala His 
    4070                 4075                 4080             


Asp Leu  Lys Asp Met Ala Cys  Val Thr Ser Leu Ile  Lys Ile Tyr 
    4085                 4090                 4095             


Ile Pro  Gln Ala Phe Leu Lys  Asp Ser Ser Gly Ser  Glu Leu Thr 
    4100                 4105                 4110             


Tyr Thr  Ile Pro Lys Asp Thr  Asp Lys Ala Cys Leu  Lys Gly Leu 
    4115                 4120                 4125             


Phe Gln  Ala Leu Asp Glu Asn  Leu His Gln Leu His  Leu Thr Gly 
    4130                 4135                 4140             


Tyr Gly  Ile Ser Asp Thr Thr  Leu Glu Glu Val Phe  Leu Met Leu 
    4145                 4150                 4155             


Leu Gln  Asp Ser Asn Lys Lys  Ser His Ile Ala Leu  Gly Thr Glu 
    4160                 4165                 4170             


Ser Glu  Leu Gln Asn His Arg  Pro Thr Gly His Leu  Ser Gly Tyr 
    4175                 4180                 4185             


Cys Gly  Ser Leu Ala Arg Pro  Ala Thr Val Gln Gly  Val Gln Leu 
    4190                 4195                 4200             


Leu Arg  Ala Gln Val Ala Ala  Ile Leu Ala Arg Arg  Leu Arg Arg 
    4205                 4210                 4215             


Thr Leu  Arg Ala Gly Lys Ser  Thr Leu Ala Asp Leu  Leu Leu Pro 
    4220                 4225                 4230             


Val Leu  Phe Val Ala Leu Ala  Met Gly Leu Phe Met  Val Arg Pro 
    4235                 4240                 4245             


Leu Ala  Thr Glu Tyr Pro Pro  Leu Arg Leu Thr Pro  Gly His Tyr 
    4250                 4255                 4260             


Gln Arg  Ala Glu Thr Tyr Phe  Phe Ser Ser Gly Gly  Asp Asn Leu 
    4265                 4270                 4275             


Asp Leu  Thr Arg Val Leu Leu  Arg Lys Phe Arg Asp  Gln Asp Leu 
    4280                 4285                 4290             


Pro Cys  Ala Asp Leu Asn Pro  Arg Gln Lys Asn Ser  Ser Cys Trp 
    4295                 4300                 4305             


Arg Thr  Asp Pro Phe Ser His  Pro Glu Phe Gln Asp  Ser Cys Gly 
    4310                 4315                 4320             


Cys Leu  Lys Cys Pro Asn Arg  Ser Ala Ser Ala Pro  Tyr Leu Thr 
    4325                 4330                 4335             


Asn His  Leu Gly His Thr Leu  Leu Asn Leu Ser Gly  Phe Asn Met 
    4340                 4345                 4350             


Glu Glu  Tyr Leu Leu Ala Pro  Ser Glu Lys Pro Arg  Leu Gly Gly 
    4355                 4360                 4365             


Trp Ser  Phe Gly Leu Lys Ile  Pro Ser Glu Ala Gly  Gly Ala Asn 
    4370                 4375                 4380             


Gly Asn  Ile Ser Lys Pro Pro  Thr Leu Ala Lys Val  Trp Tyr Asn 
    4385                 4390                 4395             


Gln Lys  Gly Phe His Ser Leu  Pro Ser Tyr Leu Asn  His Leu Asn 
    4400                 4405                 4410             


Asn Leu  Ile Leu Trp Gln His  Leu Pro Pro Thr Val  Asp Trp Arg 
    4415                 4420                 4425             


Gln Tyr  Gly Ile Thr Leu Tyr  Ser His Pro Tyr Gly  Gly Ala Leu 
    4430                 4435                 4440             


Leu Asn  Glu Asp Lys Ile Leu  Glu Ser Ile Arg Gln  Cys Gly Val 
    4445                 4450                 4455             


Ala Leu  Cys Ile Val Leu Gly  Phe Ser Ile Leu Ser  Ala Ser Ile 
    4460                 4465                 4470             


Gly Ser  Ser Val Val Arg Asp  Arg Val Ile Gly Ala  Lys Arg Leu 
    4475                 4480                 4485             


Gln His  Ile Ser Gly Leu Gly  Tyr Arg Met Tyr Trp  Phe Thr Asn 
    4490                 4495                 4500             


Phe Leu  Tyr Asp Met Leu Phe  Tyr Leu Val Ser Val  Cys Leu Cys 
    4505                 4510                 4515             


Val Ala  Val Ile Val Ala Phe  Gln Leu Thr Ala Phe  Thr Phe Arg 
    4520                 4525                 4530             


Lys Asn  Leu Ala Ala Thr Ala  Leu Leu Leu Ser Leu  Phe Gly Tyr 
    4535                 4540                 4545             


Ala Thr  Leu Pro Trp Met Tyr  Leu Met Ser Arg Ile  Phe Ser Ser 
    4550                 4555                 4560             


Ser Asp  Val Ala Phe Ile Ser  Tyr Val Ser Leu Asn  Phe Ile Phe 
    4565                 4570                 4575             


Gly Leu  Cys Thr Met Pro Ile  Thr Ile Met Pro Arg  Leu Leu Ala 
    4580                 4585                 4590             


Ile Ile  Ser Lys Ala Lys Asn  Leu Gln Asn Ile Tyr  Asp Val Leu 
    4595                 4600                 4605             


Lys Trp  Val Phe Thr Ile Phe  Pro Gln Phe Cys Leu  Gly Gln Gly 
    4610                 4615                 4620             


Leu Val  Glu Leu Cys Tyr Asn  Gln Ile Lys Tyr Asp  Leu Thr His 
    4625                 4630                 4635             


Asn Phe  Gly Ile Asp Ser Tyr  Val Ser Pro Phe Glu  Met Asn Phe 
    4640                 4645                 4650             


Leu Gly  Trp Ile Phe Val Gln  Leu Ala Ser Gln Gly  Thr Val Leu 
    4655                 4660                 4665             


Leu Leu  Leu Arg Val Leu Leu  His Trp Asp Leu Leu  Arg Trp Pro 
    4670                 4675                 4680             


Arg Gly  His Ser Thr Leu Gln  Gly Thr Val Lys Ser  Ser Lys Asp 
    4685                 4690                 4695             


Thr Asp  Val Glu Lys Glu Glu  Lys Arg Val Phe Glu  Gly Arg Thr 
    4700                 4705                 4710             


Asn Gly  Asp Ile Leu Val Leu  Tyr Asn Leu Ser Lys  His Tyr Arg 
    4715                 4720                 4725             


Arg Phe  Phe Gln Asn Ile Ile  Ala Val Gln Asp Ile  Ser Leu Gly 
    4730                 4735                 4740             


Ile Pro  Lys Gly Glu Cys Phe  Gly Leu Leu Gly Val  Asn Gly Ala 
    4745                 4750                 4755             


Gly Lys  Ser Thr Thr Phe Lys  Met Leu Asn Gly Glu  Val Ser Leu 
    4760                 4765                 4770             


Thr Ser  Gly His Ala Ile Ile  Arg Thr Pro Met Gly  Asp Ala Val 
    4775                 4780                 4785             


Asp Leu  Ser Ser Ala Gly Thr  Ala Gly Val Leu Ile  Gly Tyr Cys 
    4790                 4795                 4800             


Pro Gln  Gln Asp Ala Leu Asp  Glu Leu Leu Thr Gly  Trp Glu His 
    4805                 4810                 4815             


Leu Tyr  Tyr Tyr Cys Ser Leu  Arg Gly Ile Pro Arg  Gln Cys Ile 
    4820                 4825                 4830             


Pro Glu  Val Ala Gly Asp Leu  Ile Arg Arg Leu His  Leu Glu Ala 
    4835                 4840                 4845             


His Ala  Asp Lys Pro Val Ala  Thr Tyr Ser Gly Gly  Thr Lys Arg 
    4850                 4855                 4860             


Lys Leu  Ser Thr Ala Leu Ala  Leu Val Gly Lys Pro  Asp Ile Leu 
    4865                 4870                 4875             


Leu Leu  Asp Glu Pro Ser Ser  Gly Met Asp Pro Cys  Ser Lys Arg 
    4880                 4885                 4890             


Tyr Leu  Trp Gln Thr Ile Met  Lys Glu Val Arg Glu  Gly Cys Ala 
    4895                 4900                 4905             


Ala Val  Leu Thr Ser His Ser  Met Glu Glu Cys Glu  Ala Leu Cys 
    4910                 4915                 4920             


Thr Arg  Leu Ala Ile Met Val  Asn Gly Ser Phe Lys  Cys Leu Gly 
    4925                 4930                 4935             


Ser Pro  Gln His Ile Lys Asn  Arg Phe Gly Asp Gly  Tyr Thr Val 
    4940                 4945                 4950             


Lys Val  Trp Leu Cys Lys Glu  Ala Asn Gln His Cys  Thr Val Ser 
    4955                 4960                 4965             


Asp His  Leu Lys Leu Tyr Phe  Pro Gly Ile Gln Phe  Lys Gly Gln 
    4970                 4975                 4980             


His Leu  Asn Leu Leu Glu Tyr  His Val Pro Lys Arg  Trp Gly Cys 
    4985                 4990                 4995             


Leu Ala  Asp Leu Phe Lys Val  Ile Glu Asn Asn Lys  Thr Phe Leu 
    5000                 5005                 5010             


Asn Ile  Lys His Tyr Ser Ile  Asn Gln Thr Thr Leu  Glu Gln Val 
    5015                 5020                 5025             


Phe Ile  Asn Phe Ala Ser Glu  Gln Gln Gln Thr Leu  Gln Ser Thr 
    5030                 5035                 5040             


Leu Asp  Pro Ser Thr Asp Ser  His His Thr His His  Leu Pro Ile 
    5045                 5050                 5055             


<210> 16
<211> 17209
<212> DNA
<213> Homo sapiens

<400> 16
ggactgagag cagggagcag caggcatggg gcatgccggg tgccagttca aagccctgct       60

gtggaagaat tggctctgca gactcaggaa cccggtcctt ttccttgctg aattcttctg      120

gccttgtatc ctgtttgtaa ttctgacagt tcttcgtttt caagaacctc ccagatacag      180

agacatttgt tatttgcagc cccgagatct acccagctgt ggtgttatcc cctttgttca      240

aagccttctt tgtaacactg gatcaaggtg taggaacttc agctatgaag ggtcaatgga      300

gcatcatttt cgtttgtcta ggttccaaac tgcagctgac cccaagaaag tcaacaacct      360

ggccttttta aaagagatac aagacctggc agaggaaatt catggaatga tggacaaggc      420

aaaaaactta aaaagacttt gggtagaacg atccaacact ccagattctt cttatggttc      480

cagttttttt acaatggatc tcaataagac cgaggaggta atattgaaac tggaaagcct      540

ccatcagcag cctcatatct gggattttct acttttactg ccgagactac acacaagcca      600

tgatcatgtg gaagatggca tggatgttgc agtgaacctt ctccagacca ttttgaattc      660

cttaatatcc ctagaagatt tagattggct tccactcaac caaacttttt cccaggtttc      720

tgaacttgta ctgaatgtga ccatttcgac actgacattt ctgcagcaac atggagtagc      780

agtcaccgag ccagtttacc acctgtccat gcagaatata gtgtgggatc cacagaaagt      840

ccagtatgat ctcaaatccc agtttggctt tgrtgatctt cacacggaac agatcctgaa      900

ctcttcagct gaactgaagg agattcccac agacacttcc ttggagaaga tggtgtgttc      960

agtcttgtct agcacatcag aggatgaagc tgagaaatgg ggccacgttg gaggctgcca     1020

ccctaagtgg tcagaagcca aaaactatct tgtccatgca gtcagctggc tgcgagtcta     1080

ccaacaggtg tttgttcagt ggcaacaggg tagcctgctt cagaagacac tcacaggcat     1140

gggccatagt ctggaggctc tcaggaatca gtttgaagaa gagagcaagc cctggaaggt     1200

ggtggaagct ctgcacactg cactgctcct gctgaatgac agcttgtcag cagatggccc     1260

aaaagataat catacatttc caaagatatt acagcatctg tggaaattgc aaagcttgct     1320

gcaaaacctg ccccagtggc cggcactgaa gagatttctt cagcttgatg gagctctcag     1380

aaatgcgata gctcagaatt tacattttgt ccaagaagtc ctcatttgcc tggagacatc     1440

agctaatgat tttaaatggt ttgaacttaa ccaattgaaa ctggaaaagg atgtgttctt     1500

ttgggagctg aaacagatgt tggcgaagaa tgctgtctgc ccgaatggtc gtttctctga     1560

gaaggaggtc tttttgccgc ctggaaactc cagcatatgg ggtggtctcc agggactgtt     1620

gtgctattgt aactcctctg agacgagtgt tttaaacaag ctacttggtt cagtagagga     1680

tgctgatcgt attttgcaag aggtcattac ttggcacaaa aatatgtcag ttttaatacc     1740

tgaagaatat ttggactggc aggaacttga gatgcagctg tcagaagcaa gcctttcctg     1800

tactcggctc ttcctgctgc tgggagctga tccctctcct gagaatgatg tcttttctag     1860

tgactgtaag caccagcttg tctccacagt gatatttcat acacttgaaa aaacacaatt     1920

tttcctggaa caagcatatt attggaaagc cttcaaaaag tttatcagga agacttgcga     1980

agtggcccaa tatgtaaata tgcaagagag tttccagaac agactattgg cttttcctga     2040

ggaatctcct tgttttgaag aaaacatgga ttggaaaatg atcagtgata attattttca     2100

atttttgaat aacttactca agtctccaac agcttccata tccagggctt taaatttcac     2160

aaagcacctt ctaatgatgg aaaagaagtt gcacaccctt gaggatgaac aaatgaactt     2220

tcttttatca tttgtggaat tttttgagaa attattgttg cctaatcttt ttgactcctc     2280

cattgttccc agtttccaca gcctcccatc tctcacagag gatattctga atataagttc     2340

tctgtggaca aatcatttaa aaagtttaaa gagagaccca tctgccactg atgctcagaa     2400

actcttggaa tttggcaacg aagtgatttg gaaaatgcag actctcggaa gtcactggat     2460

aaggaaggaa ccaaaaaatc ttttgagatt catagaatta atactttttg aaattaatcc     2520

caaattacta gaattatggg cctatggcat ttcaaaagga aaaagagcta aattggaaaa     2580

cttctttaca cttttaaatt tttctgttcc agaaaatgag attctgagta caagttttaa     2640

cttttcccag ttgttccatt cagattggcc taaatcacca gctatgaaca tagattttgt     2700

acgtttaagt gaggctataa taactagtct ccatgaattt ggatttttgg agcaggaaca     2760

gatctcagaa gctctgaaca cagtctacgc tatcaggaat gcatctgatc ttttctcagc     2820

cctttctgaa ccacaaaaac aagaagttga taaaattttg actcacatac acctaaatgt     2880

cttccaggac aaggattcag ctttacttct gcaaatttat tcttcatttt accgatatat     2940

ttatgaatta ttgaatattc agagtagagg ctcttcgttg actttcctta cacaaatctc     3000

aaaacacatt ttggatatca taaaacaatt taatttccaa aacatcagta aagcatttgc     3060

atttttattt aagacagcag aggttcttgg gggaatttct aatgtatctt actgtcagca     3120

attgctttca atttttaact ttttggagct tcaggcccaa tccttcatgt ctacagaggg     3180

ccaagaactg gaagtgatcc acactacttt gacaggcctc aaacagctgc tcataattga     3240

tgaagatttt cgtatttctt tatttcaata tatgagccaa ttcttcaaca gttcagtaga     3300

agacctattg gataataaat gcttgatttc ggacaataaa cacatttctt ccgtaaatta     3360

ttcaacaagt gaggagtctt catttgtttt tccattggca caaatttttt caaacctctc     3420

agcaaatgtc agtgtgttca acaagtttat gtccattcac tgtaccgttt catggcttca     3480

aatgtggact gaaatctggg aaaccatatc tcaattattt aagtttgaca tgaatgtttt     3540

cacatctctt catcatggtt tcactcagct tttggatgaa ttggaagatg atgtgaaagt     3600

ctctaaaagc tgccagggta tacttcccac ccataatgtt gctagactca tattaaattt     3660

gtttaaaaat gtaactcaag ccaatgactt ccataattgg gaggacttcc tggatctcag     3720

ggattttttg gtagctttag gtaatgcatt agtttcagta aaaaaactta acttggagca     3780

agtggagaaa tcccttttca ccatggaagc tgccctgcat cagttgaaga catttccatt     3840

caacgaaagt acaagcagag agtttttaaa ttctctgctt gaagttttca ttgagtttag     3900

cagtacctca gaatatatag tcagaaatct agattcaata aatgactttc tttcaaataa     3960

tctcacaaat tatggagaaa aatttgaaaa tatcatcact gagctaagag aagcaatagt     4020

atttcttaga aatgtatcac atgatcgaga tttgttttcc tgtgctgata ttttccaaaa     4080

tgttactgag tgtattttag aagatggctt tttatatgta aatacctcac agaggatgtt     4140

acgtattcta gacacgttaa attccacatt ttcctctgag aacacaatta gcagtctgaa     4200

aggatgcatt gtatggttag atgtcataaa ccatttgtat ttgttgtcta actccagttt     4260

ttcacaaggt cgtcttcaaa atattttggg gaatttcaga gatatagaaa acaaaatgaa     4320

ctctatatta aaaattgtaa cttgggtgtt aaatataaaa aaacctcttt gttcatcaaa     4380

tggctcacat ataaattgtg tcaatattta cttgaaagat gtaactgact ttctaaatat     4440

tgtacttact acagtctttg aaaaagagaa gaaacctaaa tttgagattt tattagctct     4500

tttaaatgat tccacaaagc aagtaaggat gagtatcaac aacttaacaa cagactttga     4560

ttttgcatct cagtccaatt ggagatattt tactgaatta attctaagac caatagaaat     4620

gtcagatgaa attcctaatc agtttcaaaa tatttggctt catttaataa cactggggaa     4680

ggaatttcag aagcttgtaa aaggtattta ttttaacatc ctggaaaata attcctcttc     4740

taaaactgaa aacttgttaa acatatttgc caccagtcca aaagaaaagg atgtaaacag     4800

tgtaggcaat tccatttatc acttagctag ttaccttgcc ttcagcttat ctcatgacct     4860

ccaaaattca ccaaaaataa taatttcacc tgaaataatg aaagctacag gtcttggtat     4920

tcaactgata agggatgtgt tcaactcctt aatgcctgta gttcatcaca ctagtccaca     4980

aaatgcaggt tatatgcaag ctttgaagaa ggtaacttct gtcatgcgta cccttaagaa     5040

agcagacata gaccttttag tggatcagct tgaacaagtt agtgtaaacc taatggattt     5100

ctttaagaat atcagtagtg tgggaactgg caatttagtg gtcaatttgc ttgttggctt     5160

gatggaaaaa tttgcagaca gctcacattc ttggaatgtt aatcatctgc tgcagctctc     5220

acgcctgttt cctaaagatg ttgtggatgc tgtgatagat gtgtactatg tgcttcctca     5280

tgctgtaagg ctcctgcagg gagtacctgg taaaaacatc actgaaggcc tcaaggatgt     5340

ctacagcttc acactccttc atggcataac catttcaaat atcaccaagg aagacttcgc     5400

aattgtgata aaaattcttt tggatacaat tgaattagta tcagataagc cagatattat     5460

ttcagaggct ttagcttgtt ttcctgtggt ttggtgctgg aatcacacaa attctggatt     5520

tcggcagaat tcaaagatag acccctgcaa tgtccatggg ctcatgtctt cttcctttta     5580

tggcaaagtg gccagtatac ttgatcattt ccacctgtct ccccaaggtg aagattcacc     5640

atgttcaaat gaaagctccc gaatggaaat aactaggaaa gtggtctgca taattcatga     5700

attagtggac tggaattcta ttcttctgga gctctctgaa gtcttccatg ttaacatttc     5760

tcttgtgaaa actgtgcaga aattttggca taagatatta ccgtttgtcc caccttcaat     5820

aaatcaaact agggatagca tctctgaact ctgtcctagt ggttccataa agcaagttgc     5880

tttgcaaatc atagaaaaac ttaaaaatgt caactttaca aaagttacat caggtgaaaa     5940

tattcttgac aaactaagta gtttaaacaa gatccttaac attaatgaag acacagagac     6000

atctgttcaa aatattattt cctcaaattt ggaaaggaca gtacaattga tttctgaaga     6060

ctggagccta gaaaaaagta cgcataatct actctcttta ttcatgatgc tccagaatgc     6120

aaatgtcaca ggtagcagtt tagaagcatt atcaagtttt attgaaaaaa gtgaaacacc     6180

ttacaacttt gaagaactat ggcccaagtt tcaacaaatc atgaaagacc taacccaaga     6240

ttttagaatc agacacctgc tttctgaaat gaacaaagga atcaaaagta taaattcaat     6300

ggctcttcaa aagataactt tgcagtttgc ccatttcctg gaaatcctgg attcaccgtc     6360

attgaagaca ttagaaatta ttgaagattt tctattggtc acaaaaaact ggcttcagga     6420

atatgcaaat gaggattact ccagaatgat agaaacatta ttcattcctg tgaccaatga     6480

gagttcaact gaagatatag ctttgttagc caaagctatt gctacttttt ggggctcttt     6540

aaaaaatata tctagagcag gcaattttga tgttgccttt cttacccatc tgctaaatca     6600

agaacagctg actaatttct cagttgttca gctgcttttt gaaaacatcc taattaattt     6660

gatcaataac ttagctggga attctcagga agcagcttgg aacttaaatg atactgacct     6720

tcaaataatg aatttcatta accttatctt gaaccatatg cagtcagaaa ctagtaggaa     6780

aacagttctc tctctgagaa gcatagtaga tttcacagaa cagtttttga aaacattctt     6840

ctcccttttt ctaaaggaag attctgagaa caaaatatct cttctgctga aatatttcca     6900

caaagatgtt attgcagaga tgagttttgt cccaaaagat aaaattctag aaattctgaa     6960

actggatcaa tttcttaccc tgatgataca agacagattg atgaacattt tttcaagttt     7020

aaaggagact atatatcacc taatgaaaag ttcatttata ttagacaatg gagaatttta     7080

ttttgatact catcaaggac tgaagttcat gcaagattta tttaatgccc ttctcaggga     7140

aacttcaatg aaaaataaga ctgaaaataa tatagacttt ttcacagtgg tgagtcagtt     7200

gtttttccat gtgaataagt ctgaggacct cttcaaactc aatcaagatc ttgggtcagc     7260

tcttcacctt gtaagagaat gttcaacaga gatggcaaga cttctggata caattttaca     7320

ctctcctaat aaggacttct atgctttgta tcctaccctc caagaagtta tacttgctaa     7380

tctaacggat ttgcttttct ttataaataa ttcattccct ctaagaaaca gagcaacatt     7440

agaaattact aagagattag ttggtgctat ttcaagagca agtgaagaaa gtcacgtcct     7500

gaaacccctc ttagaaatgt ctgggactct ggtcatgctg ttgaatgaca gtgctgacct     7560

gagagatctt gccacatcaa tggactccat tgtgaaactt cttaagctgg tcaagaaagt     7620

ttcggggaag atgtccacag tttttaaaac tcattttatc tccaatacca aggacagtgt     7680

gaaattcttt gacactctgt attccatcat gcaacaaagt gttcaaaatc ttgtgaaaga     7740

aatagctact ttaaaaaaaa tagatcattt cacatttgaa aagataaatg atttgttggt     7800

gccatttctt gacttggcct ttgaaatgat tggggtagaa ccttatatat catcaaactc     7860

tgatattttc agtatgtcac ctagcatact ctcatatatg aaccaatcta aggacttttc     7920

tgatattttg gaagaaattg ctgaattttt aacatctgtg aaaatgaact tggaagatat     7980

gaggagtctt gcggtagcat ttaacaatga gactcaaaca ttttctatgg attctgtcaa     8040

cttaygggaa gaaattctgg gttgcttagt tcctataaat aacatcacca accaaatgga     8100

cttcttatac cctaatccaa tttccactca tagtggccct caagatataa aatgggaaat     8160

aattcatgaa gtgatccttt ttttggataa aatattatca caaaacagca cagaaatagg     8220

atctttcttg aaaatggtga tctgtctcac cttagaagct ctttggaaaa acttaaagaa     8280

agataattgg aatgtttcta atgtgttgat gacgtttact cagcatccaa ataacctttt     8340

gaaaaccata gaaacagttt tagaggcctc cagtggaatt aaaagtgact atgaaggtga     8400

tttgaataaa agtttatatt ttgacacacc tttgagtcag aatataactc atcatcaact     8460

tgaaaaagca atccataatg ttttaagtag aatagctctc tggaggaaag gacttcgttt     8520

taacaactct gaatggataa cttccacaag aactttgttt cagccacttt ttgagatttt     8580

cattaaagca accaccggaa agaatgtcac atcagaaaaa gaagagagaa ccgagaaaga     8640

gatgattgac tttccttata gtttcaaacc atttttctgt ttggagaaat acctgggagg     8700

attatttgta ttgactaaat actggcaaca aatcccacta acagatcaaa gtgttgttga     8760

gatttgtgaa gttttccagc agactgtgaa gccctcagaa gccatggaga tgctgcagaa     8820

agtgaagatg atggtcgtac gtgtgctcac catcgttgca gaaaaccctt cctggaccaa     8880

ggacattttg tgtgctactc tgagttgcaa gcaaaatggg ataaggcatc tcattttatc     8940

tgctatacaa ggggtcactt tggcgcagga ccacttccag gaaattgaaa agatatggtc     9000

ctcgccgaat cagctaaatt gtgaaagtct tagcaagaat ctttctagca ccttggagag     9060

cttcaagagc agcttggaaa atgccactgg ccaggactgc acaagccagc cgaggctgga     9120

gacggtgcag cagcacttgt acatgttggc caaaagcctc gaggaaactt ggtcatcagg     9180

gaatcccatc atgacttttc tcagcaattt cacagtaact gaggatgtaa aaataaaaga     9240

tttgatgaag aatatcacca agttgactga ggagcttcgc tcttccatcc aaatctcgaa     9300

tgagactatc catagcattc tagaagcaaa tatttcccac tccaaggttc tcttcagtgc     9360

cctcaccgta gctctgtctg gaaagtgtga tcaggaaatc cttcatctcc tgctgacatt     9420

tcccaaaggg gaaaaatctt ggatcgcagc ggaggaactc tgtagcctgc cagggtcaaa     9480

agtgtattct ctgattgtgt tgctgagtcg aaacttggat gtgcgagctt tcatttacaa     9540

gactctgatg ccttctgaag caaatggctt gctcaactcc ttgctggata tagtttccag     9600

cctcagcgcc ttgcttgcca aagcccagca cgtctttgag tatcttcctg agtttcttca     9660

cacatttaaa atcactgcct tgctagaaac cctggacttt caacaggttt cacaaaatgt     9720

ccaggccaga agttcagctt ttggttcttt ccagtttgtg atgaagatgg tttgcaagga     9780

ccaagcatca ttccttagcg attctaatat gtttattaat ttgcccagag ttaaggaact     9840

cttggaagat gacaaagaaa aattcaacat tcctgaagat tcaacaccgt tttgcttgaa     9900

gctttatcag gaaattctac aattgccaaa tggtgctttg gtgtggacct tcctaaaacc     9960

catattgcat ggaaaaatac tatacacacc aaacactcca gaaattaaca aggtcattca    10020

aaaggctaat tacacctttt atattgtgga caaactaaaa actttatcag aaacactgct    10080

ggaaatgtcc agccttttcc agagaagtgg aagtggccag atgttcaacc agctgcagga    10140

ggccctgaga aacaaatttg taagaaactt tgtagaaaac cagttgcaca ttgatgtaga    10200

caaacttact gaaaaactcc agacatacgg agggctgctg gatgagatgt ttaaccatgc    10260

aggcgctgga cgcttccgtt tcttgggcag catcttggtc aatctctctt cctgcgtggc    10320

actgaaccgt ttccaggctc tgcagtctgt cgacatcctg gagactaaag cacatgaact    10380

cttgcagcag aacagcttct tggccagtat cattttcagc aattccttat tcgacaagaa    10440

cttcagatca gagtctgtca aactgccacc ccatgtctca tacacaatcc ggaccaatgt    10500

gttatacagc gtgcgaacag atgtggtaaa aaacccttct tggaagttcc accctcagaa    10560

tctaccagct gatgggttca aatataacta cgtctttgcc ccactgcaag acatgatcga    10620

aagagccatc attttggtgc agactgggca ggaagccctg gaaccagcag cacagactca    10680

ggcggcccct tacccctgcc ataccagcga cctattcctg aacaacgttg gtttcttttt    10740

tccactgata atgatgctga cgtggatggt gtctgtggcc agcatggtca gaaagttggt    10800

gtatgagcag gagatacaga tagaagagta tatgcggatg atgggagtgc atccagtgat    10860

ccatttcctg gcctggttcc tggagaacat ggctgtgttg accataagca gtgctactct    10920

ggccatcgtt ctgaaaacaa gtggcatctt tgcacacagc aataccttta ttgttttcct    10980

ctttctcttg gattttggga tgtcagtcgt catgctgagc tacctcttga gtgcattttt    11040

cagccaagct aatacagcgg ccctttgtac cagcctggtg tacatgatca gctttctgcc    11100

ctacatagtt ctattggttc tacataacca attaagtttt gttaatcaga catttctgtg    11160

ccttctttcg acaaccgcct ttggacaagg ggtatttttt attacattcc tggaaggaca    11220

agagacaggg attcaatgga ataatatgta ccaggctctg gaacaagggg gcatgacatt    11280

tggctgggtt tgctggatga ttctttttga ttcaagcctt tattttttgt gtggatggta    11340

cttgagcaac ttgattcctg gaacatttgg tttacggaaa ccatggtatt tcccctttac    11400

tgcctcatat tggaagagtg tgggtttctt ggtggagaaa aggcaatact ttctaagttc    11460

tagtctgttc ttcttcaatg agaactttga caataaaggg tcatcactgc aaaacaggga    11520

aggagagctt gaaggaagtg ccccgggagt caccctggtg tctgtgacca aggaatatga    11580

gggccacaag gctgtggtcc aagacctcag cctgaccttc tacagagacc aaatcaccgc    11640

cctgctgggg acaaacggtg ccgggaaaac cactatcata tccatgttga cggggctcca    11700

ccctcccact tctggaacca tcatcatcaa tggcaagaac ctacagacag acctgtcgag    11760

ggtcagaatg gagcttggtg tgtgtccgca gcaggacatc ctgttggaca acctcaccgt    11820

ccgggaacat ttgctgctct ttgcttccat aaaggcgcct cagtggacca agaaggagct    11880

gcatcagcaa gtcaatcaaa ctcttcagga tgtggactta actcagcatc agcacaaaca    11940

gacccgagct ctgtctggag gcctgaagag gaagctctcc cttggcattg ctttcatggg    12000

catgtcgagg accgtggttc tggatgagcc caccagtggg gtggaccctt gctcccggca    12060

tagcctgtgg gacattctgc tcaagtaccg agaaggtcgt acgatcatct tcacaaccca    12120

ccacctggat gaagccgaag cgctgagtga ccgcgtggcc gtcctccagc atgggaggct    12180

caggtgctgc ggtcctccct tctgcctgaa ggaggcatat ggccaggggc tccgcctgac    12240

actcacgagg cagccttctg ttctggaggc ccatgatctg aaagacatgg cttgtgttac    12300

atccctgata aagatctata ttccacaagc atttctcaaa gacagcagtg gaagtgagct    12360

gacctacacc attccaaagg acacagacaa ggcctgcttg aaagggctct tccaggccct    12420

ggatgagaac ctgcatcagc tgcacctgac gggctatggg atctcagaca ccaccttaga    12480

agaggtgttt ttgatgcttt tgcaagattc caacaagaaa tctcacattg ccctggggac    12540

tgagtcagag ctgcagaacc acaggcctac aggacatctg tctggctact gtggctccct    12600

agcacggccc gcaactgtgc agggcgtcca gctgctccgc gcacaagtgg ccgcgatcct    12660

ggcccggagg ctccgccgca cgctgcgcgc cgggaagagc accctcgccg acctgctgct    12720

gccagtcctc ttcgtggcct tggccatggg cttgttcatg gtgagacccc tggccaccga    12780

gtaccctccc ctcagactca cacctggaca ttaccagcgg gccgagacct actttttcag    12840

cagtgggggc gacaacttgg acctcacccg tgtgcttctg cggaagttta gagatcaaga    12900

tttgccctgt gcagatttaa acccacgcca gaagaattct tcatgctggc gcacagatcc    12960

cttttctcac ccagaattcc aggattcatg tggctgcctg aagtgtccaa atagaagtgc    13020

tagtgctccc tacctgacca accacctggg ccacacactg ttgaatctct caggcttcaa    13080

tatggaggag tacttgctgg caccatctga aaaaccaagg cttggaggtt ggtcttttgg    13140

attaaaaatc cccagtgaag ctggaggtgc aaatggaaac atatcaaaac ccccaactct    13200

ggcaaaggtg tggtataatc agaagggttt tcattcccta ccttcctact taaatcatct    13260

aaacaacctt attttgtggc agcacctacc ccctactgtg gactggagac aatacggaat    13320

aacactctac agccacccat atggaggggc cttgctgaac gaggacaaga tcctggagag    13380

catccgtcag tgtggagtgg ccctctgcat cgtgctggga ttctccatcc tgtctgcatc    13440

catcggcagc tctgtggtga gggacagggt gattggagcc aaaaggttgc agcacataag    13500

tggccttggc tacaggatgt actggttcac aaacttccta tatgacatgc tcttttactt    13560

ggtttccgtc tgcctgtgtg ttgccgttat tgtcgccttc cagttaacag cttttacttt    13620

ccgcaagaac ttggcagcca cggccctcct gctgtcactt ttcggatatg caactcttcc    13680

atggatgtac ctgatgtcca gaatcttttc cagttcggac gtggctttca tttcctatgt    13740

ctcactaaac ttcatctttg gcctttgtac catgcccata accattatgc cccggttgct    13800

agccatcatc tccaaagcta agaatttaca gaatatctat gatgtcctca agtgggtctt    13860

tactattttt cctcaattct gtcttggtca aggactggta gaactctgct ataatcagat    13920

caaatatgac ctgacccaca acttcggcat tgattcctat gtgagtccct ttgagatgaa    13980

ctttctgggc tggatcttcg tgcaactggc ctcgcagggc acagtacttc tcctcttgag    14040

ggttctgcta cactgggacc ttctgcgatg gccaaggggt cattctactc tccaaggcac    14100

agtcaaatct tctaaggata cagatgttga aaaagaggaa aagagagtgt ttgaaggaag    14160

gaccaatgga gacattcttg tgttatacaa ccttagtaaa cattatcgac gctttttcca    14220

gaatattatt gctgtgcaag atattagttt gggcatacca aaaggagagt gctttggact    14280

tctaggggtg aatggagctg ggaagagcac gactttcaaa atgctgaatg gtgaagtttc    14340

tctaacttca ggacatgcta tcatcaggac tcccatggga gacgccgtgg acctgtcttc    14400

tgctggcacg gcaggcgtgc tcattggcta ctgtccccag caggatgccc tggacgagct    14460

tctgactggt tgggaacatc tctattatta ctgtagctta cgcgggattc caaggcagtg    14520

catccctgag gttgctggag acctcatcag gcgcttacac ctcgaagccc acgcggacaa    14580

acctgtggcc acctacagtg ggggaaccaa gcggaaactc tctacagccc tggccctggt    14640

ggggaaacct gacattcttt tattggatga gcccagctct gggatggatc cctgctctaa    14700

gcggtacctg tggcaaacaa taatgaagga ggttcgggaa ggctgtgctg cggtgctgac    14760

ctcccacagc atggaggagt gtgaggctct ttgcacaaga ctggccataa tggttaacgg    14820

cagcttcaaa tgtcttggtt ctcctcagca catcaaaaat aggtttggtg atggttatac    14880

agtcaaagtt tggctctgta aggaagcaaa tcaacattgc actgtttctg accacttgaa    14940

gctttatttt ccaggaattc agttcaaggg acagcacctg aatttattag aatatcatgt    15000

gccaaaaaga tggggatgcc tagctgactt gttcaaagtt atagagaaca ataaaacctt    15060

cttgaatatt aagcattatt ccattaacca aaccactttg gagcaggtat ttattaattt    15120

tgcttctgag cagcagcaaa ctctacaatc tactcttgat ccatccactg acagtcacca    15180

cacacatcac ttgcccatct gagcactaaa gaagtttcca taaggaataa aaccttgtct    15240

tccattacaa ttaacagtca aggataaaac aagcacgcgc acaatcaagg agctggaaca    15300

cactctccag gccgtcaaat tattctcttg ttcattttct attttgaatc tccttgttag    15360

ttaataacca ccaaatggaa aggtcattct ttctgcagac ttttggggag ctcctccaaa    15420

acatttgttc tctttaccat gccagatgga caccagcttc tttgtgacaa aggcatgaat    15480

gatttgacag tgtccaaact gagacattct ggagctggaa agcctgtcac actagagtgt    15540

gtgtgacatg tccactctaa acatgtcact tttctgttaa gaaaactgag ccccctcccc    15600

acaggttaaa aaactttagt aacttgtttg tatagaaaat agtaacaagg actattttct    15660

attgttgtca tctatttact agatacatgt ttttaatgat tttaatgtaa gcttttatta    15720

atactgatga cattatatgg tatgatatga aaaaatcacc aattttttac atataaaaga    15780

taccttttta aaaaaatagg ttttaagagc tcttttagta tacactttag caaaattaat    15840

taaattgaac tagttactct gtatcaatta cagtagttct accagaatct cccaggttat    15900

aatttatgag ggtagagaaa taaaatgtag atgcattttc tttttcttca tttggatgaa    15960

taattactgt tttttgttat tctaagtcag tgtttttcaa agcgtagtgg tccccatatt    16020

agctgcattg ccatcttctg ggagcttgca agaaatgtac attctcagga tccactccag    16080

acctattgaa tctcaaattc tggggcttaa acaagcacat tccaagttaa gaaccaatga    16140

cctaagggaa tgtctggtta cctcctagtt atacaagcaa aatctgcata gtatgtagtc    16200

ttttttattt atttattttt tttttttgag gcggagtctc gctctgtcac ccaggctgga    16260

gtgcagtggc gcgatgtcgg ctcactgcaa gctccgcctc ctgggttcac gccattctcc    16320

tgcctcagcc tccccagcag ctgggactac aggcacacat cgccacaccc ggctaatttt    16380

tagtattttt agtagagacg gggtttcacc gtgttagcca ggatggtctc tatctcctga    16440

ccttgtgatc cgcccccctc cacctcccaa agtgctggga ttacaggcgt gagccaccgt    16500

gtccggccgt agtttatttt aaaatatatt tttaaaagct ttgtaaaaat tatgtcattc    16560

tcagaattgt tgtcttcaaa gcattgtcag atgtagagtg ctcagatgtg gctcttaaag    16620

actatataca tctgaatttt tcatcctata gttagtaaga tgcataaaat caatccacta    16680

ctgaaatagt ttccagtcag acatttctga gttcagacat ttctcaacat tcttttaaca    16740

acatttttct gaatcctcaa tagaaaatca cattaatctt attttaaaat ttggcctttt    16800

tcaacactaa cgttgagtac cggtagcttt gtgatcaaag gcatatactt ccttatgaga    16860

tttctttact aaagcaagat ttcattaaat ctctatttcc taaatatcat tctatacaaa    16920

agatattttt taaacggtaa ggattaagac aatcactgat agctttgttg tgagcaattt    16980

tgattcccat gtatcacatg aattacactt ccttaaataa attacagttt atggctgtat    17040

gatttattct ctaattctaa catagtctag ttgtcaaaag gaaatatgta atctttttat    17100

gattgttgaa tcaataaata ccaatttgtg aaacatgaat gtgtttaaac tgcagtgaat    17160

aaatgagatg tgctttaatt taacccaaaa aaaaaaaaaa aaaaaaaaa                17209


<210> 17
<211> 931
<212> PRT
<213> Homo sapiens

<400> 17
Met Lys Ile Gln Lys Lys Leu Thr Gly Cys Ser Arg Leu Met Leu Leu 
1               5                   10                  15      


Cys Leu Ser Leu Glu Leu Leu Leu Glu Ala Gly Ala Gly Asn Ile His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Thr Asp Lys Gly Ser Phe Val Gly Asn Ile 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Gln Pro Gln Glu Leu Ala Asp Gly Gly Val 
    50                  55                  60                  


Arg Ile Val Ser Arg Gly Arg Met Pro Leu Phe Ala Leu Asn Pro Arg 
65                  70                  75                  80  


Ser Gly Ser Leu Ile Thr Ala Arg Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Ala Gln Ser Met Pro Cys Leu Val Ser Phe Asn Ile Leu Val Glu Asp 
            100                 105                 110         


Lys Met Lys Leu Phe Pro Val Glu Val Glu Ile Ile Asp Ile Asn Asp 
        115                 120                 125             


Asn Thr Pro Gln Phe Gln Leu Glu Glu Leu Glu Phe Lys Met Asn Glu 
    130                 135                 140                 


Ile Thr Thr Pro Gly Thr Arg Val Ser Leu Pro Phe Gly Gln Asp Leu 
145                 150                 155                 160 


Asp Val Gly Met Asn Ser Leu Gln Ser Tyr Gln Leu Ser Ser Asn Pro 
                165                 170                 175     


His Phe Ser Leu Asp Val Gln Gln Gly Ala Asp Gly Pro Gln His Pro 
            180                 185                 190         


Glu Met Val Leu Gln Ser Pro Leu Asp Arg Glu Glu Glu Ala Val His 
        195                 200                 205             


His Leu Ile Leu Thr Ala Ser Asp Gly Gly Glu Pro Val Arg Ser Gly 
    210                 215                 220                 


Thr Leu Arg Ile Tyr Ile Gln Val Val Asp Ala Asn Asp Asn Pro Pro 
225                 230                 235                 240 


Ala Phe Thr Gln Ala Gln Tyr His Ile Asn Val Pro Glu Asn Val Pro 
                245                 250                 255     


Leu Gly Thr Gln Leu Leu Met Val Asn Ala Thr Asp Pro Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Glu Val Thr Tyr Ser Phe His Asn Val Asp His Arg Val 
        275                 280                 285             


Ala Gln Ile Phe Arg Leu Asp Ser Tyr Thr Gly Glu Ile Ser Asn Lys 
    290                 295                 300                 


Glu Pro Leu Asp Phe Glu Glu Tyr Lys Met Tyr Ser Met Glu Val Gln 
305                 310                 315                 320 


Ala Gln Asp Gly Ala Gly Leu Met Ala Lys Val Lys Val Leu Ile Lys 
                325                 330                 335     


Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Ile Thr Ser Val 
            340                 345                 350         


Thr Thr Ala Val Pro Glu Asn Phe Pro Pro Gly Thr Ile Ile Ala Leu 
        355                 360                 365             


Ile Ser Val His Asp Gln Asp Ser Gly Asp Asn Gly Tyr Thr Thr Cys 
    370                 375                 380                 


Phe Ile Pro Gly Asn Leu Pro Phe Lys Leu Glu Lys Leu Val Asp Asn 
385                 390                 395                 400 


Tyr Tyr Arg Leu Val Thr Glu Arg Thr Leu Asp Arg Glu Leu Ile Ser 
                405                 410                 415     


Gly Tyr Asn Ile Thr Ile Thr Ala Ile Asp Gln Gly Thr Pro Ala Leu 
            420                 425                 430         


Ser Thr Glu Thr His Ile Ser Leu Leu Val Thr Asp Ile Asn Asp Asn 
        435                 440                 445             


Ser Pro Val Phe His Gln Asp Ser Tyr Ser Ala Tyr Ile Pro Glu Asn 
    450                 455                 460                 


Asn Pro Arg Gly Ala Ser Ile Phe Ser Val Arg Ala His Asp Leu Asp 
465                 470                 475                 480 


Ser Asn Glu Asn Ala Gln Ile Thr Tyr Ser Leu Ile Glu Asp Thr Ile 
                485                 490                 495     


Gln Gly Ala Pro Leu Ser Ala Tyr Leu Ser Ile Asn Ser Asp Thr Gly 
            500                 505                 510         


Val Leu Tyr Ala Leu Arg Ser Phe Asp Tyr Glu Gln Phe Arg Asp Met 
        515                 520                 525             


Gln Leu Lys Val Met Ala Arg Asp Ser Gly Asp Pro Pro Leu Ser Ser 
    530                 535                 540                 


Asn Val Ser Leu Ser Leu Phe Leu Leu Asp Gln Asn Asp Asn Ala Pro 
545                 550                 555                 560 


Glu Ile Leu Tyr Pro Ala Leu Pro Thr Asp Gly Ser Thr Gly Val Glu 
                565                 570                 575     


Leu Ala Pro Leu Ser Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Arg Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Arg Leu 
        595                 600                 605             


Leu Lys Ala Ser Glu Pro Gly Leu Phe Ser Val Gly Leu His Thr Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Ala Leu Leu Asp Arg Asp Ala Leu Lys Gln 
625                 630                 635                 640 


Ser Leu Val Val Ala Val Gln Asp His Gly Gln Pro Pro Leu Ser Ala 
                645                 650                 655     


Thr Val Thr Leu Thr Val Ala Val Ala Asp Arg Ile Ser Asp Ile Leu 
            660                 665                 670         


Ala Asp Leu Gly Ser Leu Glu Pro Ser Ala Lys Pro Asn Asp Ser Asp 
        675                 680                 685             


Leu Thr Leu Tyr Leu Val Val Ala Ala Ala Ala Val Ser Cys Val Phe 
    690                 695                 700                 


Leu Ala Phe Val Ile Val Leu Leu Ala His Arg Leu Arg Arg Trp His 
705                 710                 715                 720 


Lys Ser Arg Leu Leu Gln Ala Ser Gly Gly Gly Leu Ala Ser Met Pro 
                725                 730                 735     


Gly Ser His Phe Val Gly Val Asp Gly Val Arg Ala Phe Leu Gln Thr 
            740                 745                 750         


Tyr Ser His Glu Val Ser Leu Thr Ala Asp Ser Arg Lys Ser His Leu 
        755                 760                 765             


Ile Phe Pro Gln Pro Asn Tyr Ala Asp Thr Leu Ile Ser Gln Glu Ser 
    770                 775                 780                 


Cys Glu Lys Lys Gly Phe Leu Ser Ala Pro Gln Ser Leu Leu Glu Asp 
785                 790                 795                 800 


Lys Lys Glu Pro Phe Ser Gln Gln Ala Pro Pro Asn Thr Asp Trp Arg 
                805                 810                 815     


Phe Ser Gln Ala Gln Arg Pro Gly Thr Ser Gly Ser Gln Asn Gly Asp 
            820                 825                 830         


Asp Thr Gly Thr Trp Pro Asn Asn Gln Phe Asp Thr Glu Met Leu Gln 
        835                 840                 845             


Ala Met Ile Leu Ala Ser Ala Ser Glu Ala Ala Asp Gly Ser Ser Thr 
    850                 855                 860                 


Leu Gly Gly Gly Ala Gly Thr Met Gly Leu Ser Ala Arg Tyr Gly Pro 
865                 870                 875                 880 


Gln Phe Thr Leu Gln His Val Pro Asp Tyr Arg Gln Asn Val Tyr Ile 
                885                 890                 895     


Pro Gly Ser Asn Ala Thr Leu Thr Asn Ala Ala Gly Lys Arg Asp Gly 
            900                 905                 910         


Lys Ala Pro Ala Gly Gly Asn Gly Asn Lys Lys Lys Ser Gly Lys Lys 
        915                 920                 925             


Glu Lys Lys 
    930     


<210> 18
<211> 4602
<212> DNA
<213> Homo sapiens

<400> 18
atgaagattc agaaaaagct gactggctgc agcaggctga tgcttctgtg tctttctctg       60

gagctgctgt tggaagctgg ggctgggaat attcactact cagtgccgga agagacagac      120

aaaggttcct tcgtaggcaa catcgccaag gacctagggc tgcaacccca ggagctggca      180

gatggcggag tccgcatcgt ctccagaggt aggatgccgc ttttcgctct gaatcctaga      240

agtggcagct tgatcaccgc gcgcaggata gaccgggagg agctctgcgc tcagagcatg      300

ccgtgtctcg tgagttttaa tatccttgtt gaggataaaa tgaagctttt tcctgttgaa      360

gtagaaataa ttgatattaa tgacaacact ccccaattcc agttagagga actggagttt      420

aaaatgaatg aaataacgac tccaggtacc agagtctcat tgccttttgg gcaagacctt      480

gatgtgggta tgaactcact ccagagctac caactcagct ctaaccctca tttctccctg      540

gatgtgcaac agggagccga tgggcctcaa catccagaga tggtgctgca gagtccctta      600

gacagagaag aagaagctgt ccaccacctc atcctcacag cttctgatgg gggtgaacca      660

gtccgttcag ggaccctcag aatttacatt caggtggtgg atgcaaatga caatcctcca      720

gcatttactc aggcacaata ccatataaat gtccccgaaa acgtgccgct gggtactcag      780

ctgctcatgg taaatgccac tgaccctgat gagggagcca atggggaagt aacgtactcc      840

tttcacaatg tagaccacag agtggcccaa atatttcgtt tagattctta cacaggagaa      900

atatcaaata aagaaccact agatttcgaa gaatacaaaa tgtattcaat ggaagttcaa      960

gcccaggatg gtgcggggct catggctaaa gttaaggtac tgatcaaagt tttggatgta     1020

aatgataatg ccccagaagt gaccatcacc tctgtcacca ctgcagttcc agaaaacttt     1080

cctcctggga ccataattgc tcttatcagt gtgcatgacc aggactcagg agacaatggc     1140

tacaccacat gtttcattcc tggaaattta ccctttaaat tggaaaagtt agttgataat     1200

tattaccgtt tagtgactga aagaacactg gacagagaac ttatctctgg gtacaacatc     1260

acaataacag caatagacca aggaactcca gctctatcta ctgaaactca catttcacta     1320

ctagtgacag atatcaatga caactcccca gtcttccatc aggactccta ctctgcctac     1380

attcccgaaa acaaccccag aggagcctcc atcttctctg tgagggccca cgacttggac     1440

agcaatgaga atgcacaaat cacttactcc ctaatagagg acactatcca gggggcaccc     1500

ctatctgcct acctctccat caactccgac actggggtcc tgtatgcgct gcgatccttc     1560

gactatgagc agttccggga catgcaactg aaagtgatgg cgcgggacag tggggatccg     1620

cccctcagca gcaacgtgtc tctcagccta ttcctgctgg accagaacga caacgcgccc     1680

gagatcctgt accccgccct ccccacagat ggttctaccg gcgtggagct ggcgcccctc     1740

tccgcagagc ccggctacct ggtgaccaag gtggtggcgg tggacagaga ctcgggccag     1800

aacgcctggc tgtcctaccg cctgctcaag gccagcgagc cgggactctt ctcggtgggt     1860

ctgcacacgg gcgaggtgcg cacggcgcga gccctgctgg acagagacgc gctcaagcag     1920

agtctcgtgg tggccgtcca ggaccacggc cagcccccgc tctccgccac tgtcacgctc     1980

accgtggccg tggccgacag gatctccgac atcctggccg acctgggcag cctcgagccc     2040

tccgccaaac ccaacgattc ggacctcact ctgtacctgg tggtggcggc ggccgcggtc     2100

tcctgcgtct tcctggcctt cgtcatcgtg ctgctggcgc acaggctgcg gcgctggcac     2160

aagtcacgtc tgctacaggc ttcgggaggc ggcttagcga gcatgcccgg ttcgcacttt     2220

gtgggcgtgg acggggttcg ggctttcctg cagacctatt cccacgaggt ctccctcact     2280

gcggactcgc ggaagagcca cctgattttc ccccagccca actatgcgga cacactcatc     2340

agccaggaga gctgtgagaa aaagggtttt ctatcagcac cccagtcttt acttgaagac     2400

aaaaaggaac cattttctca gcaagccccg cccaacacgg actggcgttt ctctcaggcc     2460

cagagacccg gcaccagcgg ctcccaaaat ggcgatgaca ccggcacctg gcccaacaac     2520

cagtttgaca cagagatgct gcaagccatg atcttggcgt ccgccagtga agctgctgat     2580

gggagctcca ccctgggagg gggtgccggc accatgggat tgagcgcccg ctacggaccc     2640

cagttcaccc tgcagcacgt gcccgactac cgccagaatg tctacatccc aggcagcaat     2700

gccacactga ccaacgcagc tggcaagcgg gatggcaagg ccccagcagg tggcaatggc     2760

aacaagaaga agtcgggcaa gaaggagaag aagtaacatg gaggccaggc caagagccac     2820

agggcggcct ctccccaacc agcccagctt ctccttacct gcacccaggc ctcagagttt     2880

cagggctaac ccccagaata ctggtagggg ccaaggccat gctccccttg ggaaacagaa     2940

acaagtgccc agtcagcacc taccccttcc cccccagggg gttgaatatg caaaagcagt     3000

tccgctggga acccccatcc aatcaactgc tgtacccatg ggggtagtgg ggttactgta     3060

gacaccaaga accatttgcc acaccccgtt tagttacagc tgaactcctc catcttccaa     3120

atcaatcagg cccatccatc ccatgcctcc ctcctcccca ccccactcca acagttcctc     3180

tttcccgagt aaggtggttg gggtgttgaa gtaccaagta acctacaagc ctcctagttc     3240

tgaaaagttg gaagggcatc atgacctctt ggcctctcct ttgattctca atcttccccc     3300

aaagcatggt ttggtgccag ccccttcacc tccttccaga gcccaagatc aatgctcaag     3360

ttttggagga catgatcacc atccccatgg tactgatgct tgctggattt agggagggca     3420

ttttgctacc aagcctcttc ccaacgccct ggggaccagt cttctgtttt gtttttcatt     3480

gtttgacgtt tccactgcat gccttgactt cccccacctc ctcctcaaac aagagactcc     3540

actgcatgtt ccaagacagt atggggtggt aagataagga agggaagtgt gtggatgtgg     3600

atggtggggg catggacaaa gcttgacaca tcaagttatc aaggccttgg aggaggctct     3660

gtatgtcctc aggggactga caacatcctc cagattccag ccataaacca ataactaggc     3720

tggacccttc ccactacata atagggctca gcccaggcag ccagctttgg gctgagctaa     3780

caggaccaat ggattaaact ggcatttcag tccaaggaag ctcgaagcag gtttaggacc     3840

aggtcccctt gagaggtcag aggggcctct gtgggtgctg ggtactccag aggtgccact     3900

ggtggaaggg tcagcggagc cccagcagga agggtgggcc agccaggcca ttcttagtcc     3960

ctgggttggg gaggcaggga gctagggcag ggaccaaatg aacagaaagt ctcagcccag     4020

gatggggctt cttcaacagg gcccctgccc tcctgaagcc tcagtccttc accttgccag     4080

gtgccgtttc tcttccgtga aggccactgc ccaggtcccc agtgcgcccc ctagtggcca     4140

tagcctggtt aaagttcccc agtgcctcct tgtgcataga ccttcttctc ccaccccctt     4200

ctgcccctgg gtccccggcc atccagcggg gctgccagag aaccccagac ctgcccttac     4260

agtagtgtag cgccccctcc ctctttcggc tggtgtagaa tagccagtag tgtagtgcgg     4320

tgtgctttta cgtgatggcg ggtgggcagc gggcggcggg ctccgcgcag ccgtctgtcc     4380

ttgatctgcc cgcggcggcc cgtgttgtgt tttgtgctgt gtccacgcgc taaggcgacc     4440

ccctcccccg tactgacttc tcctataagc gcttctcttc gcatagtcac gtagctccca     4500

ccccaccctc ttcctgtgtc tcacgcaagt tttatactct aatatttata tggctttttt     4560

tcttcgacaa aaaaataata aaacgtttct tctgaaaagc tg                        4602


<210> 19
<211> 3298
<212> DNA
<213> Homo sapiens

<400> 19
gcagacgtta ctgccctctt gcgtgccccg gccacccccg ggcggcttgt agccggtgcg       60

cggggtggct ggggctacgt gcagagctgt cgcggagccg gagcagcagc ggtgaagccc      120

ctcggctcgg ccgagaccgc cgtgcccatt gctcgcctcg gttgccgccg ctttagccgc      180

agccgctgct gccgccgccg ggggagaggc agcctattgt ctttctccgc ggcgaaggtg      240

aggagctgtc tcggctcggc ccgcggggga gccccgggag ccgcacggtg gcatttttca      300

actccgctgg agccaatgcc caggaggaac aaagggtgtg ctgccagccc ctggctcacc      360

cagtggcctc gtcccagaaa aagccagagg tagcggcccc agccccagag agtgggggtg      420

agtctgtgtt tggggagacc caccgggccc tgcagggggc catggagaag ctgcagcgac      480

tttatggaag gagaaggtgg acctgaagga gcgggtagag aaactagagc ttcaattcat      540

ccacctctca ggacagacag acaccatagg gagaaagtac atcagccagg gggcagtgtc      600

agagacgcag cactgggaga ggaggacatc gtcaggctgg cccaggacca ggaggagatg      660

aaggtgaacc tgcaggagct gcggggcagg tgttgcagct tgtgggagac cacaaggagg      720

ggcatggcaa attctgacca ttgcccagaa ccctgctgat gagcccactc taggagcccc      780

aatagcccag gagcttgggt gtgctgacga gcagggtgat caccactgga ttgctgacag      840

atagaggacg tgggaccgtg actatcaccc ctaatctgca gtggatttgg ctctcggcac      900

tcccaggctg ggagctggat acctgccctg gcagcatgac tcagactgca tgacagagaa      960

cgtggccagt ggagacggca cactggaaat cagagtgaat gttcttgaaa gagggtcacg     1020

ggtcaacaag gcccagccaa aggatgcagt agaaccattt tccttagaaa tctttgggag     1080

tgaagtaggc ttcagccact cccatccctg cccttgcggc taccactacc ccattagttt     1140

agacagggtc gggcggggag gggtgtggag aagaaatgag cttgcctgtg gcccccaggc     1200

tccctctgtc ctagctcagg tctgggtgcc attctttaca ctcgtgtgct cgctcacgca     1260

cacatcacac accttgctgg tcacacagtc acagactcgc ctctgctcct gtggtccagt     1320

ggccggacac cccctgggat ggctcaaagg agtcaggact tggaagtggg gacatcaggg     1380

tagctgaagg aaatccacac acccagagca tctcggagtt cagactctca gacctgaagt     1440

aggcgccccc gggactgggc taggagttgg acggaatgga ggatggagga cagcgagaag     1500

aaaggaagag aaatgcaacg tgtgggcagc cgccaagagt gaaaatagag ggaagtgtca     1560

tgcaagtgct ggacagaagg cggcaggtgg gacgagcccc acagccccct cctcaaaaac     1620

gaccacctcc aggactcagt gatccctggg gggcaggctc tgccagccct cggccacacg     1680

tggctccggc acccatggtc ccagtgcctt ggatggagac ggccagttct ggcggccaga     1740

tgtggtgctc tggaatccag tcccatttcc ttcctggcca cgcctgtcca gcggcctctt     1800

cagccgcatt cagcccctac ttacctgggg accccggctg gggcacgaga gcaccagggg     1860

ggtagggccc aaagggatca ggggaagcct ctggcctgga gggtatgggg cacgcttccc     1920

caagggcgga cccggcagga ggaagcccag gagctgggtc ctgccgccca ggagctgggc     1980

cctgccaccc aggccgggct agggacatgg cagggcctgg gcatcctgac gctggacttg     2040

ggcgacctgg gaggcacagg gaggggagag atgggcgacc ccgccccagc gcagtgccgg     2100

ccacacccca aggcggttgc cagagcttaa gccccgcccc cagcagcgag aacatcccag     2160

ctccacaccc cccccccccc cccccggcag ccagtgctcc ttgtcaagct ccccccgtca     2220

ctccaggtgg gagccacccc ggtgaggggg tgtgccactt gcccccaggg cactcctctg     2280

ggcatcccgg gtgggggatt ttggggccgt ggggggcagt ctttggtacc tgtgttcgtc     2340

agggatgctc tgacaaccag gtgtcgtcca cgggcggggg catgggcatg gtgacagtgg     2400

tcctgttgat gtcaccgatg atgctgagcg cctccttcag cgcgtggtgc atgtgcagca     2460

tctcgtcatg ctgctgtgcc tgctctgcca actcctccat cagtgtgttc tggttcccac     2520

atgagtacat attggccagc ggctccgaga tgatgaactc cggggtctga gagtgggcaa     2580

acagggaaga aggttgggac ctggtgcctg tgccgccctg gctgccttgc tgggcccttc     2640

tgggactgtg cgctggactt ggagcccctt ggagtatggc ttttcacacg ggcttctata     2700

ccgcttcgac tggaagatcc acctccccac tgccttttct cactcagatg gggacaccga     2760

ggtccagagg aaaagacacc tgtcaaatgt cacagatctg ggaggggact taagacttat     2820

catgccaaga ggacacctgt ctactcagtt tttttttggt ggggcggggg gcggtgatag     2880

ggtctcgctc tgtcaccagg ctggagtaca gtgatgactg ctcactgcag cctccacctc     2940

ctgggctcaa agtgatcctc caacgtcagc ctctcgagta gctaggacta caggcacatg     3000

ccaccaccaa gcccagctat ttttaaaatt tttgtgtgga gacaaggtct cactatgtgg     3060

cccaggctgg tctcgaactc ctgggctcaa gtgatcctcc tgcctcggcc tccaggagtg     3120

ggagttggag ttgatgcctg gatacaggag ctctgtgggt gggagtgaga caaaacacag     3180

ggtcctgagc tctggggacc aagcaatgtc ctctggtgaa aaaaatcctg gacttgctgg     3240

cagaagattt gcctcttact cgccatgtgc tctgaataca tttacctgcc ctctggga       3298


<210> 20
<211> 5037
<212> DNA
<213> Homo sapiens

<400> 20
gttttcactt ggtcggaatg gggagagtgt gcaagagatc gctgcgggac aggttcctag       60

agatcgctcc gggacggtcg tgacggcccc cgagggacat gagagaagag gagcggcgct      120

caggttattc caggatcttt ggagacccga ggaaagccgt gttgaccaaa agcaagacaa      180

atgactcaca gagaaaaaag atggcagaac caagggcaac taaagccgtc aggttctgaa      240

cagctggtag atgggctggc ttactgaagg acatgattca gactgtcccg gacccagcag      300

ctcatatcaa ggaagcctta tcagttgtga gtgaggacca gtcgttgttt gagtgtgcct      360

acggaacgcc acacctggct aagacagaga tgaccgcgtc ctcctccagc gactatggac      420

agacttccaa gatgagccca cgcgtccctc agcaggattg gctgtctcaa cccccagcca      480

gggtcaccat caaaatggaa tgtaacccta gccaggtgaa tggctcaagg aactctcctg      540

atgaatgcag tgtggccaaa ggcgggaaga tggtgggcag cccagacacc gttgggatga      600

actacggcag ctacatggag gagaagcaca tgccaccccc aaacatgacc acgaacgagc      660

gcagagttat cgtgccagca gatcctacgc tatggagtac agaccatgtg cggcagtggc      720

tggagtgggc ggtgaaagaa tatggccttc cagacgtcaa catcttgtta ttccagaaca      780

tcgatgggaa ggaactgtgc aagatgacca aggacgactt ccagaggctc acccccagct      840

acaacgccga catccttctc tcacatctcc actacctcag agagactcct cttccacatt      900

tgacttcaga tgatgttgat aaagccttac aaaactctcc acggttaatg catgctagaa      960

acacagattt accatatgag ccccccagga gatcagcctg gaccggtcac ggccacccca     1020

cgccccagtc gaaagctgct caaccatctc cttccacagt gcccaaaact gaagaccagc     1080

gtcctcagtt agatccttat cagattcttg gaccaacaag tagccgcctt gcaaatccag     1140

gcagtggcca gatccagctt tggcagttcc tcctggagct cctgtcggac agctccaact     1200

ccagctgcat cacctgggaa ggcaccaacg gggagttcaa gatgacggat cccgacgagg     1260

tggcccggcg ctggggagag cggaagagca aacccaacat gaactacgat aagctcagcc     1320

gcgccctccg ttactactat gacaagaaca tcatgaccaa ggtccatggg aagcgctacg     1380

cctacaagtt cgacttccac gggatcgccc aggccctcca gccccacccc ccggagtcat     1440

ctctgtacaa gtacccctca gacctcccgt acatgggctc ctatcacgcc cacccacaga     1500

agatgaactt tgtggcgccc caccctccag ccctccccgt gacatcttcc agtttttttg     1560

ctgccccaaa cccatactgg aattcaccaa ctgggggtat ataccccaac actaggctcc     1620

ccaccagcca tatgccttct catctgggca cttactacta aagacctggc ggaggctttt     1680

cccatcagcg tgcattcacc agcccatcgc cacaaactct atcggagaac atgaatcaaa     1740

agtgcctcaa gaggaatgaa aaaagcttta ctggggctgg ggaaggaagc cggggaagag     1800

atccaaagac tcttgggagg gagttactga agtcttacta cagaaatgag gaggatgcta     1860

aaaatgtcac gaatatggac atatcatctg tggactgacc ttgtaaaaga cagtgtatgt     1920

agaagcatga agtcttaagg acaaagtgcc aaagaaagtg gtcttaagaa atgtataaac     1980

tttagagtag agtttggaat cccactaatg caaactggga tgaaactaaa gcaatagaaa     2040

caacacagtt ttgacctaac ataccgttta taatgccatt ttaaggaaaa ctacctgtat     2100

ttaaaaatag aaacatatca aaaacaagag aaaagacacg agagagactg tggcccatca     2160

acagacgttg atatgcaact gcatggcatg tgctgttttg gttgaaatca aatacattcc     2220

gtttgatgga cagctgtcag ctttctcaaa ctgtgaagat gacccaaagt ttccaactcc     2280

tttacagtat taccgggact atgaactaaa aggtgggact gaggatgtgt atagagtgag     2340

cgtgtgattg tagacagagg ggtgaagaag gaggaggaag aggcagagaa ggaggagacc     2400

agggctggga aagaaacttc tcaagcaatg aagactggac tcaggacatt tggggactgt     2460

gtacaatgag ttatggagac tcgagggttc atgcagtcag tgttatacca aacccagtgt     2520

taggagaaag gacacagcgt aatggagaaa ggggaagtag tagaattcag aaacaaaaat     2580

gcgcatctct ttctttgttt gtcaaatgaa aattttaact ggaattgtct gatatttaag     2640

agaaacattc aggacctcat cattatgtgg gggctttgtt ctccacaggg tcaggtaaga     2700

gatggccttc ttggctgcca caatcagaaa tcacgcaggc attttgggta ggcggcctcc     2760

agttttcctt tgagtcgcga acgctgtgcg tttgtcagaa tgaagtatac aagtcaatgt     2820

ttttccccct ttttatataa taattatata acttatgcat ttatacacta cgagttgatc     2880

tcggccagcc aaagacacac gacaaaagag acaatcgata taatgtggcc ttgaatttta     2940

actctgtatg cttaatgttt acaatatgaa gttattagtt cttagaatgc agaatgtatg     3000

taataaaata agcttggcct agcatggcaa atcagattta tacaggagtc tgcatttgca     3060

ctttttttag tgactaaagt tgcttaatga aaacatgtgc tgaatgttgt ggattttgtg     3120

ttataattta ctttgtccag gaacttgtgc aagggagagc caaggaaata ggatgtttgg     3180

cacccaaatg gcgtcagcct ctccaggtcc ttcttgcctc ccctcctgtc ttttatttct     3240

agcccctttt ggaacagaag gaccccgggt ttcacattgg agcctccata tttatgcctg     3300

gaatggaaag aggcctatga agctggggtt gtcattgaga aattctagtt cagcacctgg     3360

tcacaaatca cccttaattc ctgctatgat taaaatacat ttgttgaaca gtgaacaagc     3420

taccactcgt aaggcaaact gtattattac tggcaaataa agcgtcatgg atagctgcaa     3480

tttctcactt tacagaaaca agggataacg tctagatttg ctgcggggtt tctctttcag     3540

gagctctcac taggtagaca gctttagtcc tgctacatca gagttacctg ggcactgtgg     3600

cttgggattc actagccctg agcctgatgt tgctggctat cccttgaaga caatgtttat     3660

ttccataatc tagagtcagt ttccctgggc atcttttctt tgaatcacaa atgctgccaa     3720

ccttggtcca ggtgaaggca actcaaaagg tgaaaataca aggtgaccgt gcgaaggcgc     3780

tagccgaaac atcttagctg aataggtttc tgaactggcc cttttcatag ctgtttcagg     3840

gcctgttttt ttcacgttgc agtccttttg ctatgattat gtgaagttgc caaacctctg     3900

tgctgtggat gttttggcag tgggctttga agtcggcagg acacgattac caatgctcct     3960

gacaccccgt gtcatttgga ttagacggag cccaaccatc catcattttg cagcagcctg     4020

ggaaggccca caaagtgccc gtatctcctt agggaaaata aataaataca atcatgaaag     4080

ctggcagtta ggctgaccca aactgtgcta atggaaaaga tcagtcattt ttattttgga     4140

atgcaaagtc aagacacacc tacattcttc atagaaatac acatttactt ggataatcac     4200

tcagttctct cttcaagact gtctcatgag caagatcata aaaacaagac atgattatca     4260

tattcaattt taacagatgt tttccattag atccctcaac cctccacccc cagtccaggt     4320

tattagcaag tcttatgagc aactgggata attttggata acatgataat actgagttcc     4380

ttcaaataca taattcttaa attgtttcaa aatggcatta actctctgtt actgttgtaa     4440

tctaattcca aagccccctc caggtcatat tcataattgc atgaaccttt tctctctgtt     4500

tgtccctgtc tcttggcttg ccctgatgta tactcagact cctgtacaat cttactcctg     4560

ctggcaagag atttgtcttc ttttcttgtc ttcaattggc tttcgggcct tgtatgtggt     4620

aaaatcacca aatcacagtc aagactgtgt ttttgttcct agtttgatgc ccttatgtcc     4680

cggaggggtt cacaaagtgc tttgtcagga ctgctgcagt tagaaggctc actgcttctc     4740

ctaagccttc tgcacagatg tggcacctgc aacccaggag caggagccgg aggagctgcc     4800

ctctgacagc aggtgcagca gagatggcta cagctcagga gctgggaagg tgatggggca     4860

cagggaaagc acagatgttc tgcagcgccc caaagtgacc cattgcctgg agaaagagaa     4920

gaaaatattt tttaaaaagc tagtttattt agcttctcat taattcattc aaataaagtc     4980

gtgaggtgac taattagaga ataaaaatta ctttggacta ctcaaaaata caccaaa        5037


<210> 21
<211> 3352
<212> DNA
<213> Homo sapiens

<400> 21
ggggcgtggc gccggggatt gggagggctt cttgcaggct gctgggctgg ggctaagggc       60

tgctcagttt ccttcagcgg ggcactggga agcgccatgg cactgcaggg catctcggtc      120

gtggagctgt ccggcctggc cccgggcccg ttctgtgcta tggtcctggc tgacttcggg      180

gcgcgtgtgg tacgcgtgga ccggcccggc tcccgctacg acgtgagccg cttgggccgg      240

ggcaagcgct cgctagtgct ggacctgaag cagccgcggg gagccgccgt gctgcggcgt      300

ctgtgcaagc ggtcggatgt gctgctggag cccttccgcc gcggtgtcat ggagaaactc      360

cagctgggcc cagagattct gcagcgggaa aatccaaggc ttatttatgc caggctgagt      420

ggatttggcc agtcaggaag cttctgccgg ttagctggcc acgatatcaa ctatttggct      480

ttgtcaggtg ttctctcaaa aattggcaga agtggtgaga atccgtatgc cccgctgaat      540

ctcctggctg actttgctgg tggtggcctt atgtgtgcac tgggcattat aatggctctt      600

tttgaccgca cacgcactgg caagggtcag gtcattgatg caaatatggt ggaaggaaca      660

gcatatttaa gttcttttct gtggaaaact cagaaattga gtctgtggga agcacctcga      720

ggacagaaca tgttggatgg tggagcacct ttctatacga cttacaggac agcagatggg      780

gaattcatgg ctgttggagc aatagaaccc cagttctacg agctgctgat caaaggactt      840

ggactaaagt ctgatgaact tcccaatcag atgagcatgg atgattggcc agaaatgaag      900

aagaagtttg cagatgtatt tgcagagaag acgaaggcag agtggtgtca aatctttgac      960

ggcacagatg cctgtgtgac tccggttctg acttttgagg aggttgttca tcatgatcac     1020

aacaaggaac ggggctcgtt tatcaccagt gaggagcagg acgtgagccc ccgccctgca     1080

cctctgctgt taaacacccc agccatccct tctttcaaaa gggatccttt cataggagaa     1140

cacactgagg agatacttga agaatttgga ttcagccgcg aagagattta tcagcttaac     1200

tcagataaaa tcattgaaag taataaggta aaagctagtc tctaacttcc aggcccacgg     1260

ctcaagtgaa tttgaatact gcatttacag tgtagagtaa cacataacat tgtatgcatg     1320

gaaacatgga ggaacagtat tacagtgtcc taccactcta atcaagaaaa gaattacaga     1380

ctctgattct acagtgatga ttgaattcta aaaatggtta tcattagggc ttttgattta     1440

taaaactttg ggtacttata ctaaattatg gtagttattc tgccttccag tttgcttgat     1500

atatttgttg atattaagat tcttgactta tattttgaat gggttctagt gaaaaaggaa     1560

tgatatattc ttgaagacat cgatatacat ttatttacac tcttgattct acaatgtaga     1620

aaatgaggaa atgccacaaa ttgtatggtg ataaaagtca cgtgaaacag agtgattggt     1680

tgcatccagg ccttttgtct tggtgttcat gatctccctc taagcacatt ccaaacttta     1740

gcaacagtta tcacactttg taatttgcaa agaaaagttt cacctgtatt gaatcagaat     1800

gccttcaact gaaaaaaaca tatccaaaat aatgaggaaa tgtgttggct cactacgtag     1860

agtccagagg gacagtcagt tttagggttg cctgtatcca gtaactcggg gcctgtttcc     1920

ccgtgggtct ctgggctgtc agctttcctt tctccatgtg tttgatttct cctcaggctg     1980

gtagcaagtt ctggatctta tacccaacac acagcaacat ccagaaataa agatctcagg     2040

accccccagc aagtcgtttt gtgtctcctt ggactgagtt aagttacaag cctttcttat     2100

acctgtcttt gacaaagaag acgggattgt ctttacataa aaccagcctg ctcctggagc     2160

ttccctggac tcaacttcct aaaggcatgt gaggaagggg tagattccac aatctaatcc     2220

gggtgccatc agagtagagg gagtagagaa tggatgttgg gtaggccatc aataaggtcc     2280

attctgcgca gtatctcaac tgccgttcaa caatcgcaag aggaaggtgg agcaggtttc     2340

ttcatcttac agttgagaaa acagagactc agaagggctt cttagttcat gtttccctta     2400

gcgcctcagt gattttttca tggtggctta ggccaaaaga aatatctaac cattcaattt     2460

ataaataatt aggtccccaa cgaattaaat attatgtcct accaacttat tagctgcttg     2520

aaaaatataa tacacataaa taaaaaaata tatttttcat ttctatttca ttgttaatca     2580

caactactta ctaaggagat gtatgcacct attggacact gtgcaacttc tcacctggaa     2640

tgagattgga cactgctgcc ctcattttct gctccatgtt ggtgtccata tagtacttga     2700

ttttttatca gatggcctgg aaaacccagt ctcacaaaaa tatgaaatta tcagaaggat     2760

tatagtgcaa tcttatgttg aaagaatgaa ctacctcact agtagttcac gtgatgtctg     2820

acagatgttg agtttcattg tgtttgtgtg ttcaaatttt taaatattct gagatactct     2880

tgtgaggtca ctctaatgcc ctgggtgcct tggcacagtt ttagaaatac cagttgaaaa     2940

tatttgctca ggaatatgca actaggaagg ggcagaatca gaatttaagc tttcatattc     3000

tagccttcag tcttgttctt caaccatttt taggaacttt cccataaggt tatgttttcc     3060

agcccaggca tggaggatca cttgaggcca agagttcgag accagcctgg ggaacttggc     3120

tggacctccg tttctacgaa ataaaaataa aaaaattatc caggtatggt ggtgtgtgcc     3180

tgtagtccta tctactcaag ggtggggcag gaggatcact tgagcccagg aatttgaggc     3240

cacagtgaat taggattgca ccactgcact ctagcccagg caacagaaca agaacctgtc     3300

tctaaataaa taaataaaaa taataataat aaaaaagatg ttttccctac aa             3352


<210> 22
<211> 1464
<212> DNA
<213> Homo sapiens

<400> 22
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaacaa aagcgtgatc ttgctgggtc ggcacagcct gtttcatcct gaagacacag      300

gccaggtatt tcaggtcagc cacagcttcc cacacccgct ctacgatatg agcctcctga      360

agaatcgatt cctcaggcca ggtgatgact ccagccacga cctcatgctg ctccgcctgt      420

cagagcctgc cgagctcacg gatgctgtga aggtcatgga cctgcccacc caggagccag      480

cactggggac cacctgctac gcctcaggct ggggcagcat tgaaccagag gagttcttga      540

ccccaaagaa acttcagtgt gtggacctcc atgttatttc caatgacgtg tgtgcgcaag      600

ttcaccctca gaaggtgacc aagttcatgc tgtgtgctgg acgctggaca gggggcaaaa      660

gcacctgctc gggtgattct gggggcccac ttgtctgtaa tggtgtgctt caaggtatca      720

cgtcatgggg cagtgaacca tgtgccctgc ccgaaaggcc ttccctgtac accaaggtgg      780

tgcattaccg gaagtggatc aaggacacca tcgtggccaa cccctgagca cccctatcaa      840

ccccctattg tagtaaactt ggaaccttgg aaatgaccag gccaagactc aagcctcccc      900

agttctactg acctttgtcc ttaggtgtga ggtccagggt tgctaggaaa agaaatcagc      960

agacacaggt gtagaccaga gtgtttctta aatggtgtaa ttttgtcctc tctgtgtcct     1020

ggggaatact ggccatgcct ggagacatat cactcaattt ctctgaggac acagatagga     1080

tggggtgtct gtgttatttg tggggtacag agatgaaaga ggggtgggat ccacactgag     1140

agagtggaga gtgacatgtg ctggacactg tccatgaagc actgagcaga agctggaggc     1200

acaacgcacc agacactcac agcaaggatg gagctgaaaa cataacccac tctgtcctgg     1260

aggcactggg aagcctagag aaggctgtga gccaaggagg gagggtcttc ctttggcatg     1320

ggatggggat gaagtaagga gagggactgg accccctgga agctgattca ctatgggggg     1380

aggtgtattg aagtcctcca gacaaccctc agatttgatg atttcctagt agaactcaca     1440

gaaataaaga gctgttatac tgtg                                            1464


<210> 23
<211> 3735
<212> DNA
<213> Homo sapiens

<400> 23
agaagaaata gcaagtgccg agaagctggc atcagaaaaa cagaggggag atttgtgtgg       60

ctgcagccga gggagaccag gaagatctgc atggtgggaa ggacctgatg atacagaggt      120

gagaaataag aaaggctgct gactttacca tctgaggcca cacatctgct gaaatggaga      180

taattaacat cactagaaac agcaagatga caatataatg tctaagtagt gacatgtttt      240

tgcacatttc cagccccttt aaatatccac acacacagga agcacaaaag gaagcacaga      300

gatccctggg agaaatgccc ggccgccatc ttgggtcatc gatgagcctc gccctgtgcc      360

tggtcccgct tgtgagggaa ggacattaga aaatgaattg atgtgttcct taaaggatgg      420

gcaggaaaac agatcctgtt gtggatattt atttgaacgg gattacagat ttgaaatgaa      480

gtcacaaagt gagcattacc aatgagagga aaacagacga gaaaatcttg atggcttcac      540

aagacatgca acaaacaaaa tggaatactg tgatgacatg aggcagccaa gctggggagg      600

agataaccac ggggcagagg gtcaggattc tggccctgct gcctaaactg tgcgttcata      660

accaaatcat ttcatatttc taaccctcaa aacaaagctg ttgtaatatc tgatctctac      720

ggttccttct gggcccaaca ttctccatat atccagccac actcattttt aatatttagt      780

tcccagatct gtactgtgac ctttctacac tgtagaataa cattactcat tttgttcaaa      840

gacccttcgt gttgctgcct aatatgtagc tgactgtttt tcctaaggag tgttctggcc      900

caggggatct gtgaacaggc tgggaagcat ctcaagatct ttccagggtt atacttacta      960

gcacacagca tgatcattac ggagtgaatt atctaatcaa catcatcctc agtgtctttg     1020

cccatactga aattcatttc ccacttttgt gcccattctc aagacctcaa aatgtcattc     1080

cattaatatc acaggattaa cttttttttt taacctggaa gaattcaatg ttacatgcag     1140

ctatgggaat ttaattacat attttgtttt ccagtgcaaa gatgactaag tcctttatcc     1200

ctcccctttg tttgattttt tttccagtat aaagttaaaa tgcttagcct tgtactgagg     1260

ctgtatacag ccacagcctc tccccatccc tccagcctta tctgtcatca ccatcaaccc     1320

ctcccatgca cctaaacaaa atctaacttg taattccttg aacatgtcag gcatacatta     1380

ttccttctgc ctgagaagct cttccttgtc tcttaaatct agaatgatgt aaagttttga     1440

ataagttgac tatcttactt catgcaaaga agggacacat atgagattca tcatcacatg     1500

agacagcaaa tactaaaagt gtaatttgat tataagagtt tagataaata tatgaaatgc     1560

aagagccaca gagggaatgt ttatggggca cgtttgtaag cctgggatgt gaagcaaagg     1620

cagggaacct catagtatct tatataatat acttcatttc tctatctcta tcacaatatc     1680

caacaagctt ttcacagaat tcatgcagtg caaatcccca aaggtaacct ttatccattt     1740

catggtgagt gcgctttaga attttggcaa atcatactgg tcacttatct caactttgag     1800

atgtgtttgt ccttgtagtt aattgaaaga aatagggcac tcttgtgagc cactttaggg     1860

ttcactcctg gcaataaaga atttacaaag agctactcag gaccagttgt taagagctct     1920

gtgtgtgtgt gtgtgtgtgt gagtgtacat gccaaagtgt gcctctctct ctttgaccca     1980

ttatttcaga cttaaaaaca agcatgtttt caaatggcac tatgagctgc caatgatgta     2040

tcaccaccat atctcattat tctccagtaa atgtgataat aatgtcatct gttaacataa     2100

aaaaagtttg acttcacaaa agcagctgga aatggacaac cacaatatgc ataaatctaa     2160

ctcctaccat cagctacaca ctgcttgaca tatattgtta gaagcacctc gcatttgtgg     2220

gttctcttaa gcaaaatact tgcattaggt ctcagctggg gctgtgcatc aggcggtttg     2280

agaaatattc aattctcagc agaagccaga atttgaattc cctcatcttt taggaatcat     2340

ttaccaggtt tggagaggat tcagacagct caggtgcttt cactaatgtc tctgaacttc     2400

tgtccctctt tgtgttcatg gatagtccaa taaataatgt tatctttgaa ctgatgctca     2460

taggagagaa tataagaact ctgagtgata tcaacattag ggattcaaag aaatattaga     2520

tttaagctca cactggtcaa aaggaaccaa gatacaaaga actctgagct gtcatcgtcc     2580

ccatctctgt gagccacaac caacagcagg acccaacgca tgtctgagat ccttaaatca     2640

aggaaaccag tgtcatgagt tgaattctcc tattatggat gctagcttct ggccatctct     2700

ggctctcctc ttgacacata ttagcttcta gcctttgctt ccacgacttt tatcttttct     2760

ccaacacatc gcttaccaat cctctctctg ctctgttgct ttggacttcc ccacaagaat     2820

ttcaacgact ctcaagtctt ttcttccatc cccaccacta acctgaatgc ctagaccctt     2880

atttttatta atttccaata gatgctgcct atgggctata ttgctttaga tgaacattag     2940

atatttaaag ctcaagaggt tcaaaatcca actcattatc ttctctttct ttcacctccc     3000

tgctcctctc cctatattac tgattgcact gaacagcatg gtccccaatg tagccatgca     3060

aatgagaaac ccagtggctc cttgtggtac atgcatgcaa gactgctgaa gccagaagga     3120

tgactgatta cgcctcatgg gtggagggga ccactcctgg gccttcgtga ttgtcaggag     3180

caagacctga gatgctccct gccttcagtg tcctctgcat ctcccctttc taatgaagat     3240

ccatagaatt tgctacattt gagaattcca attaggaact cacatgtttt atctgcccta     3300

tcaatttttt aaacttgctg aaaattaagt tttttcaaaa tctgtccttg taaattactt     3360

tttcttacag tgtcttggca tactatatca actttgattc tttgttacaa cttttcttac     3420

tcttttatca ccaaagtggc ttttattctc tttattatta ttattttctt ttactactat     3480

attacgttgt tattattttg ttctctatag tatcaattta tttgatttag tttcaattta     3540

tttttattgc tgacttttaa aataagtgat tcggggggtg ggagaacagg ggagggagag     3600

cattaggaca aatacctaat gcatgtggga cttaaaacct agatgatggg ttgataggtg     3660

cagcaaacca ctatggcaca cgtatacctg tgtaacaaac ctacacattc tgcacatgta     3720

tcccagaacg taaag                                                      3735


<210> 24
<211> 403
<212> PRT
<213> Homo sapiens

<400> 24
Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210> 25
<211> 5572
<212> DNA
<213> Homo sapiens

<400> 25
cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc       60

ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt      120

gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact      180

gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc      240

tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga      300

gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct      360

gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct      420

cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg      480

aggcgcggcg gcggcggcgg cacctcccgc tcctggagcg ggggggagaa gcggcggcgg      540

cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca      600

gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc      660

ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac      720

cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt      780

cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc      840

agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc      900

aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc      960

agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca     1020

ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc     1080

aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat     1140

ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt     1200

tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg     1260

acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac     1320

agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca     1380

atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg     1440

catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg     1500

aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt     1560

attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca     1620

agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg     1680

tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca     1740

agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt     1800

tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata     1860

cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg     1920

atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag     1980

tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact     2040

tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc     2100

cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt     2160

atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc     2220

atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa     2280

taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc     2340

agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat     2400

ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat     2460

ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt     2520

tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt     2580

ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt     2640

cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt     2700

tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc     2760

tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca     2820

cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt     2880

cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa     2940

aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca     3000

aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat     3060

ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat     3120

ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag     3180

tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta     3240

gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc     3300

tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag     3360

taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc     3420

acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa     3480

tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa     3540

aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa     3600

aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat     3660

tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat     3720

catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa     3780

aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta     3840

ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct     3900

tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata     3960

aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta     4020

gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg     4080

gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt     4140

tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt     4200

acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt     4260

ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc     4320

tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag     4380

ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg     4440

ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca     4500

ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt     4560

tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat     4620

ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca     4680

gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa     4740

ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct     4800

ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag     4860

ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc     4920

tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca     4980

tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa     5040

atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt     5100

tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa     5160

tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc     5220

tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt     5280

ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca     5340

gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg     5400

aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt     5460

ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa     5520

aactgattaa agtctcattc ttgtcaaaaa aaaaaaaaaa aaaaaaaaaa aa             5572


