                         SEQUENCE LISTING

<110>  KINDRED BIOSCIENCES, INC.
       ZHAN, Hangjun, et al.
 
<120>  ERYTHROPOIETIN ANALOGS FOR VETERINARY USE

<130>  01157-0028-00PCT

<150>  US 62/785,691
<151>  2018-12-27

<150>  US 62/778,849
<151>  2018-12-12

<150>  US 62/779,332
<151>  2018-12-13

<160>  123   

<170>  PatentIn version 3.5

<210>  1
<211>  192
<212>  PRT
<213>  Canis lupus


<220>
<221>  misc_feature
<222>  (1)..(192)
<223>  Canis lupus EPO precursor form

<400>  1

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  2
<211>  166
<212>  PRT
<213>  Canis lupus


<220>
<221>  misc_feature
<222>  (1)..(166)
<223>  Canis lupus EPO mature form

<400>  2

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  3
<211>  192
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<222>  (1)..(192)
<223>  Equus caballus EPO precursor form

<400>  3

Met Gly Val Arg Glu Cys Pro Ala Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Pro Pro Leu Gly Leu Pro Ala Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Glu Gly Cys Ser Phe Gly Glu Asn 
    50                  55                  60                  


Val Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Ser Trp Lys Arg Met 
65                  70                  75                  80  


Glu Val Glu Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Gln Gly Gln Ala Leu Leu Ala Asn Ser Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Leu Arg Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala Pro Leu Arg Thr Phe Ala 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  4
<211>  166
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<222>  (1)..(166)
<223>  Equus caballus EPO mature form

<400>  4

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Glu Gly 
            20                  25                  30          


Cys Ser Phe Gly Glu Asn Val Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ser Trp Lys Arg Met Glu Val Glu Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Gln Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ser Ser Gln Pro Ser Glu Thr Leu Arg Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Ala Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  5
<211>  192
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(192)
<223>  Felis catus EPO precursor form wild-type feline EPO G44

<400>  5

Met Gly Ser Cys Glu Cys Pro Ala Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Gly Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Glu Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ser Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Leu Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  6
<211>  166
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(166)
<223>  Felis catus EPO mature form wild-type feline EPO G18

<400>  6

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Gly Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Glu Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ser Ser Gln Pro Ser Glu Thr Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  7
<211>  192
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(192)
<223>  Felis catus EPO precursor form wild-type feline EPO E44

<400>  7

Met Gly Ser Cys Glu Cys Pro Ala Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Glu Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ser Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Leu Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  8
<211>  166
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(166)
<223>  Felis catus EPO mature form wild-type feline EPO E18

<400>  8

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Glu Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ser Ser Gln Pro Ser Glu Thr Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  9
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog A precursor A56N G58T P113E S114N

<400>  9

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Asn Gln Thr Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Glu Asn Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  10
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog A mature A30N G32T P87E S88N

<400>  10

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Asn Gln Thr 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Glu Asn Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  11
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog B precursor A56N G58T P113V S114N

<400>  11

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Asn Gln Thr Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Val Asn Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  12
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog B mature A30N G32T P87V S88N

<400>  12

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Asn Gln Thr 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Val Asn Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  13
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog C precursor D81N G83T

<400>  13

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asn Val Thr Gln Gln Ala Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  14
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog C mature D55N G57T

<400>  14

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asn Val Thr Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  15
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog D precursor L138N A140T

<400>  15

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Asn Gly Thr Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  16
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog D mature L112N A114T

<400>  16

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Asn 
            100                 105                 110         


Gly Thr Gln Lys Glu Ala Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  17
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog E precursor L147N P148V E149T

<400>  17

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Asn Val Thr Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  18
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog E mature L121N P122V E123T

<400>  18

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Met Ser Asn Val Thr Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  19
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog F precursor P148E E149N A151T

<400>  19

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Leu Glu Asn Glu Thr Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  20
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog F mature P122E E123N A125T

<400>  20

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Met Ser Leu Glu Asn Glu Thr Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  21
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog G precursor A45C S172C

<400>  21

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Cys Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Cys Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  22
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog G mature A19C S146C

<400>  22

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Cys Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Cys Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  23
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog H precursor A48C H120C

<400>  23

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Cys 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu Cys Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  24
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog H mature A22C H94C

<400>  24

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Cys Glu Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu Cys Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  25
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog I precursor E49C S172C

<400>  25

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Cys Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Cys Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  26
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog I mature E23C S146C

<400>  26

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Cys Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Cys Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  27
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog J precursor P68C G92C

<400>  27

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Cys Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Trp Gln Cys Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  28
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog J mature P42C G66C

<400>  28

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Cys Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Trp 
    50                  55                  60                  


Gln Cys Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  29
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog K precursor W90C A144C

<400>  29

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Leu Glu Val Cys Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Cys 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  30
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog K mature W64C A118C

<400>  30

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Leu Glu Val Cys 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Cys Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  31
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog L precursor A86C E143C

<400>  31

Met Gly Ala Cys Glu Cys Pro Ala Leu Phe Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Gln Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Cys Leu Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ala Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Pro Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Cys Ala 
    130                 135                 140                 


Met Ser Leu Pro Glu Glu Ala Ser Pro Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  32
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Canine EPO analog L mature A60C E117C

<400>  32

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Gln Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Cys Leu Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ala Ser Gln Pro Ser Glu Thr Pro Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Cys Ala Met Ser Leu Pro Glu Glu Ala Ser Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  33
<211>  508
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<222>  (1)..(508)
<223>  Canis lupus EPO receptor precursor form

<400>  33

Met Asn His Leu Trp Thr His Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Ser Leu Pro Lys Pro Leu Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Ala Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr Ser Phe Phe 
65                  70                  75                  80  


Tyr Gln Leu Glu Gly Glu Pro Trp Lys Thr Cys Ser Leu His Gln Ala 
                85                  90                  95      


Pro Thr Thr Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Ala Thr Ala Val Ser 
        115                 120                 125             


Ser Gly Ala Leu Leu Tyr Arg Arg Ile Ile His Ile Asn Glu Val Val 
    130                 135                 140                 


Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala Asp Glu Gly 
145                 150                 155                 160 


Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Val Ala 
                165                 170                 175     


Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Gly Ser Val Ala Gly Gly 
            180                 185                 190         


Ser Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Val Leu Ser 
        195                 200                 205             


Asn Leu Arg Gly Gly Thr Arg Tyr Thr Phe Met Val Arg Ala Arg Met 
    210                 215                 220                 


Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Ala 
225                 230                 235                 240 


Ser Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
                245                 250                 255     


Leu Ile Leu Val Leu Ile Leu Leu Leu Leu Ala Val Leu Ala Leu Leu 
            260                 265                 270         


Ser His Arg Arg Thr Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
        275                 280                 285             


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
    290                 295                 300                 


Gln Leu Trp Leu Tyr Gln Asn Glu Gly Cys Leu Trp Trp Ser Pro Cys 
305                 310                 315                 320 


Thr Pro Leu Ala Glu Asp Pro Pro Ala Pro Leu Glu Val Leu Ser Glu 
                325                 330                 335     


Arg Cys Trp Gly Ala Pro Gln Ala Val Glu Pro Gly Ala Asp Asp Glu 
            340                 345                 350         


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ser Gln Asp Thr Tyr 
        355                 360                 365             


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Ser Ser Glu Asp 
    370                 375                 380                 


Val Ser Gln Ser Gly Gly Ser Leu Asp Ile Val Ala Met Asp Lys Gly 
385                 390                 395                 400 


Ser Glu Ala Ser Ser Cys Ser Ser Gly Leu Ser Leu Lys Pro Gly Pro 
                405                 410                 415     


Glu Gly Ala Leu Gly Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
            420                 425                 430         


Ser Gln Leu Leu Cys Pro Arg Ala Leu Pro Pro Glu Leu Pro Pro Thr 
        435                 440                 445             


Pro Pro His Ile Lys Tyr Leu Tyr Leu Met Val Ser Asp Ser Gly Ile 
    450                 455                 460                 


Ser Thr Asp Tyr Ser Ser Gly Gly Ser Gln Gly Ala Gln Gly Asp Ser 
465                 470                 475                 480 


Leu Asn Ser Pro Phe Leu Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
                485                 490                 495     


Pro Glu Pro Ser Pro Pro Gly Tyr Val Ala Cys Ser 
            500                 505             


<210>  34
<211>  249
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<222>  (1)..(249)
<223>  Exemplary canine EPOR ECD

<400>  34

Met Asn His Leu Trp Thr His Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Ser Leu Pro Lys Pro Leu Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Ala Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr Ser Phe Phe 
65                  70                  75                  80  


Tyr Gln Leu Glu Gly Glu Pro Trp Lys Thr Cys Ser Leu His Gln Ala 
                85                  90                  95      


Pro Thr Thr Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Ala Thr Ala Val Ser 
        115                 120                 125             


Ser Gly Ala Leu Leu Tyr Arg Arg Ile Ile His Ile Asn Glu Val Val 
    130                 135                 140                 


Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala Asp Glu Gly 
145                 150                 155                 160 


Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Val Ala 
                165                 170                 175     


Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Gly Ser Val Ala Gly Gly 
            180                 185                 190         


Ser Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Val Leu Ser 
        195                 200                 205             


Asn Leu Arg Gly Gly Thr Arg Tyr Thr Phe Met Val Arg Ala Arg Met 
    210                 215                 220                 


Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Ala 
225                 230                 235                 240 


Ser Leu Leu Thr Ala Ser Asp Leu Asp 
                245                 


<210>  35
<211>  213
<212>  PRT
<213>  Canis lupus familiaris


<220>
<221>  misc_feature
<222>  (1)..(213)
<223>  Exemplary canine EPOR minimal ECD

<400>  35

Asp Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Ala Pro 
1               5                   10                  15      


Glu Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe 
            20                  25                  30          


Trp Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr Ser Phe 
        35                  40                  45              


Phe Tyr Gln Leu Glu Gly Glu Pro Trp Lys Thr Cys Ser Leu His Gln 
    50                  55                  60                  


Ala Pro Thr Thr Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr 
65                  70                  75                  80  


Ala Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Ala Thr Ala Val 
                85                  90                  95      


Ser Ser Gly Ala Leu Leu Tyr Arg Arg Ile Ile His Ile Asn Glu Val 
            100                 105                 110         


Val Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala Asp Glu 
        115                 120                 125             


Gly Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Val 
    130                 135                 140                 


Ala Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Gly Ser Val Ala Gly 
145                 150                 155                 160 


Gly Ser Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Val Leu 
                165                 170                 175     


Ser Asn Leu Arg Gly Gly Thr Arg Tyr Thr Phe Met Val Arg Ala Arg 
            180                 185                 190         


Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro 
        195                 200                 205             


Ala Ser Leu Leu Thr 
    210             


<210>  36
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary canine EPOR ECD  Human Fc

<400>  36

Met Asn His Leu Trp Thr His Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Ser Leu Pro Lys Pro Leu Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Ala Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr Ser Phe Phe 
65                  70                  75                  80  


Tyr Gln Leu Glu Gly Glu Pro Trp Lys Thr Cys Ser Leu His Gln Ala 
                85                  90                  95      


Pro Thr Thr Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Ala Thr Ala Val Ser 
        115                 120                 125             


Ser Gly Ala Leu Leu Tyr Arg Arg Ile Ile His Ile Asn Glu Val Val 
    130                 135                 140                 


Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala Asp Glu Gly 
145                 150                 155                 160 


Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Val Ala 
                165                 170                 175     


Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Gly Ser Val Ala Gly Gly 
            180                 185                 190         


Ser Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Val Leu Ser 
        195                 200                 205             


Asn Leu Arg Gly Gly Thr Arg Tyr Thr Phe Met Val Arg Ala Arg Met 
    210                 215                 220                 


Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Ala 
225                 230                 235                 240 


Ser Leu Leu Thr Ala Ser Asp Leu Asp Ile Glu Gly Arg Met Asp Pro 
                245                 250                 255     


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            260                 265                 270         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        275                 280                 285             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    290                 295                 300                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
305                 310                 315                 320 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                325                 330                 335     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            340                 345                 350         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        355                 360                 365             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    370                 375                 380                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
385                 390                 395                 400 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                405                 410                 415     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            420                 425                 430         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    450                 455                 460                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
465                 470                 475                 480 


Ser Leu Ser Pro Gly Lys 
                485     


<210>  37
<211>  509
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<222>  (1)..(509)
<223>  Equus caballus EPO receptor precursor form

<400>  37

Met Asn His Leu Gly Ala Pro Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Ser Ser Asp 
            20                  25                  30          


Pro Arg Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Glu Asn Tyr Ser Phe Ser 
65                  70                  75                  80  


Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Arg Leu His Gln Ala 
                85                  90                  95      


Ser Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Thr 
        115                 120                 125             


Ser Gly Ala Pro Arg Tyr Arg Arg Val Ile Gln Val Asn Glu Val Val 
    130                 135                 140                 


Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Leu Ala Asp Glu Gly 
145                 150                 155                 160 


Gly His Val Leu Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Met Ala 
                165                 170                 175     


Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ala Gly Asn Ala Ala Gly 
            180                 185                 190         


Gly Ala Gln Arg Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Val Leu 
        195                 200                 205             


Ser Asn Leu Arg Gly Gln Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg 
    210                 215                 220                 


Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro 
225                 230                 235                 240 


Ala Ser Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Leu Leu Thr Leu 
                245                 250                 255     


Ser Leu Ile Leu Val Leu Ile Leu Leu Leu Leu Ala Val Leu Ala Leu 
            260                 265                 270         


Leu Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro 
        275                 280                 285             


Ser Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn 
    290                 295                 300                 


Phe Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Asn Pro 
305                 310                 315                 320 


Cys Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser 
                325                 330                 335     


Glu Arg Cys Trp Gly Val Thr Gln Ala Val Glu Pro Gly Ala Glu Asp 
            340                 345                 350         


Glu Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Arg Asp Pro 
        355                 360                 365             


Tyr Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Ser Pro Thr Ser Glu 
    370                 375                 380                 


Asp Leu Pro Gln Pro Gly Gly Gly Leu Asp Thr Ala Ala Met Asp Ala 
385                 390                 395                 400 


Gly Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Leu Lys Pro Gly 
                405                 410                 415     


Pro Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro 
            420                 425                 430         


Ser Ser Gln Leu Leu Arg Pro Arg Ala Leu Pro Pro Glu Leu Pro Pro 
        435                 440                 445             


Thr Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly 
    450                 455                 460                 


Ile Ser Thr Asp Tyr Ser Ser Gly Gly Ser Gln Gly Ala Gln Arg Gly 
465                 470                 475                 480 


Ser Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Val Pro 
                485                 490                 495     


Ala Pro Glu Pro Ser Ala Pro Ser Tyr Val Ala Cys Ser 
            500                 505                 


<210>  38
<211>  250
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<222>  (1)..(250)
<223>  Exemplary equine EPOR ECD

<400>  38

Met Asn His Leu Gly Ala Pro Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Ser Ser Asp 
            20                  25                  30          


Pro Arg Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Glu Asn Tyr Ser Phe Ser 
65                  70                  75                  80  


Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Arg Leu His Gln Ala 
                85                  90                  95      


Ser Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Thr 
        115                 120                 125             


Ser Gly Ala Pro Arg Tyr Arg Arg Val Ile Gln Val Asn Glu Val Val 
    130                 135                 140                 


Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Leu Ala Asp Glu Gly 
145                 150                 155                 160 


Gly His Val Leu Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Met Ala 
                165                 170                 175     


Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ala Gly Asn Ala Ala Gly 
            180                 185                 190         


Gly Ala Gln Arg Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Val Leu 
        195                 200                 205             


Ser Asn Leu Arg Gly Gln Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg 
    210                 215                 220                 


Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro 
225                 230                 235                 240 


Ala Ser Leu Leu Thr Ala Ser Asp Leu Asp 
                245                 250 


<210>  39
<211>  214
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<222>  (1)..(214)
<223>  Exemplary equine EPOR minimal ECD

<400>  39

Asp Pro Arg Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro 
1               5                   10                  15      


Glu Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe 
            20                  25                  30          


Trp Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Glu Asn Tyr Ser Phe 
        35                  40                  45              


Ser Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Arg Leu His Gln 
    50                  55                  60                  


Ala Ser Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr 
65                  70                  75                  80  


Ala Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala 
                85                  90                  95      


Thr Ser Gly Ala Pro Arg Tyr Arg Arg Val Ile Gln Val Asn Glu Val 
            100                 105                 110         


Val Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Leu Ala Asp Glu 
        115                 120                 125             


Gly Gly His Val Leu Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Met 
    130                 135                 140                 


Ala Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ala Gly Asn Ala Ala 
145                 150                 155                 160 


Gly Gly Ala Gln Arg Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Val 
                165                 170                 175     


Leu Ser Asn Leu Arg Gly Gln Thr Arg Tyr Thr Phe Ala Val Arg Ala 
            180                 185                 190         


Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu 
        195                 200                 205             


Pro Ala Ser Leu Leu Thr 
    210                 


<210>  40
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary equine EPOR ECD  Human Fc

<400>  40

Met Asn His Leu Gly Ala Pro Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Ser Ser Asp 
            20                  25                  30          


Pro Arg Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Glu Asn Tyr Ser Phe Ser 
65                  70                  75                  80  


Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Arg Leu His Gln Ala 
                85                  90                  95      


Ser Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Thr 
        115                 120                 125             


Ser Gly Ala Pro Arg Tyr Arg Arg Val Ile Gln Val Asn Glu Val Val 
    130                 135                 140                 


Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Leu Ala Asp Glu Gly 
145                 150                 155                 160 


Gly His Val Leu Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Met Ala 
                165                 170                 175     


Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ala Gly Asn Ala Ala Gly 
            180                 185                 190         


Gly Ala Gln Arg Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Val Leu 
        195                 200                 205             


Ser Asn Leu Arg Gly Gln Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg 
    210                 215                 220                 


Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro 
225                 230                 235                 240 


Ala Ser Leu Leu Thr Ala Ser Asp Leu Asp Ile Glu Gly Arg Met Asp 
                245                 250                 255     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            260                 265                 270         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        275                 280                 285             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
305                 310                 315                 320 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                325                 330                 335     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            340                 345                 350         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    370                 375                 380                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
385                 390                 395                 400 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                405                 410                 415     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            420                 425                 430         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        435                 440                 445             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    450                 455                 460                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
465                 470                 475                 480 


Leu Ser Leu Ser Pro Gly Lys 
                485         


<210>  41
<211>  512
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(512)
<223>  Felis catus  EPO receptor Sequence EPOR201

<400>  41

Met Asp His Leu Trp Ala Pro Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Pro Leu Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Val Asn Met Val Cys Met Arg Ala Pro Glu 
        35                  40                  45              


Ala Ser Ala Cys Gly Ser Ser Glu Arg Leu Glu Asp Leu Val Cys Phe 
    50                  55                  60                  


Trp Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr Ser Phe 
65                  70                  75                  80  


Phe Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Ser Leu His Gln 
                85                  90                  95      


Ala Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr 
            100                 105                 110         


Ala Asp Ala Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Val 
        115                 120                 125             


Ser Ser Gly Ala Pro Arg Tyr His Arg Ile Ile His Ile Asn Glu Val 
    130                 135                 140                 


Val Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala Asp Glu 
145                 150                 155                 160 


Gly Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Val 
                165                 170                 175     


Ala Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ser Gly Asn Val Ala 
            180                 185                 190         


Gly Gly Ala Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Ala 
        195                 200                 205             


Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Met Val Arg Ala 
    210                 215                 220                 


Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu 
225                 230                 235                 240 


Pro Ala Ser Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Ile Leu Thr 
                245                 250                 255     


Leu Ser Leu Ile Leu Val Leu Ile Leu Leu Leu Leu Ala Val Leu Ala 
            260                 265                 270         


Leu Leu Ser His Arg Arg Phe Thr Arg Thr Leu Lys Gln Lys Ile Trp 
        275                 280                 285             


Pro Gly Ile Pro Ser Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr 
    290                 295                 300                 


His Lys Gly Asn Phe Gln Leu Trp Leu Tyr Gln Asn Glu Gly Cys Leu 
305                 310                 315                 320 


Trp Trp Ser Pro Cys Ala Pro Phe Ala Glu Asp Pro Pro Ser Pro Leu 
                325                 330                 335     


Glu Val Leu Ser Glu Arg Cys Trp Gly Ala Thr Gln Ala Ala Glu Pro 
            340                 345                 350         


Gly Ala Glu Glu Gly Pro Leu Leu Glu Pro Leu Gly Ser Glu His Thr 
        355                 360                 365             


Gln Asp Thr Tyr Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro 
    370                 375                 380                 


Pro Ser Glu Asp Leu Pro Arg Pro Asp Gly Ser Leu Asp Met Val Ala 
385                 390                 395                 400 


Met His Lys Gly Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ser Leu 
                405                 410                 415     


Lys Pro Gly Pro Glu Gly Ala Leu Gly Ala Ser Phe Glu Tyr Thr Ile 
            420                 425                 430         


Leu Asp Pro Ser Ser Gln Leu Leu Arg Pro Arg Ala Leu Pro Pro Glu 
        435                 440                 445             


Leu Pro Pro Thr Pro Pro His Ile Lys Tyr Leu Tyr Leu Met Val Ser 
    450                 455                 460                 


Asp Ser Gly Ile Ser Thr Asp Tyr Ser Ser Gly Gly Ser Gln Glu Ala 
465                 470                 475                 480 


Gln Gly Asp Ser Ser Thr Gly Pro Tyr Leu Asn Pro Tyr Glu Asn Ser 
                485                 490                 495     


Leu Ile Pro Ala Thr Glu Thr Ser Pro Pro Ser Tyr Val Ala Cys Ser 
            500                 505                 510         


<210>  42
<211>  226
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(226)
<223>  Exemplary Feline EPOR201 ECD

<400>  42

Pro Pro Pro Asn Pro Leu Asp Pro Lys Phe Glu Ser Lys Val Asn Met 
1               5                   10                  15      


Val Cys Met Arg Ala Pro Glu Ala Ser Ala Cys Gly Ser Ser Glu Arg 
            20                  25                  30          


Leu Glu Asp Leu Val Cys Phe Trp Glu Glu Ala Ala Ser Ala Gly Val 
        35                  40                  45              


Gly Pro Asp Asn Tyr Ser Phe Phe Tyr Gln Leu Glu Gly Glu Pro Trp 
    50                  55                  60                  


Lys Pro Cys Ser Leu His Gln Ala Pro Thr Ala Arg Gly Ala Val Arg 
65                  70                  75                  80  


Phe Trp Cys Ser Leu Pro Thr Ala Asp Ala Ser Ser Phe Val Pro Leu 
                85                  90                  95      


Glu Leu Arg Val Thr Ala Val Ser Ser Gly Ala Pro Arg Tyr His Arg 
            100                 105                 110         


Ile Ile His Ile Asn Glu Val Val Leu Leu Asp Pro Pro Ala Gly Leu 
        115                 120                 125             


Leu Ala Arg Arg Ala Asp Glu Gly Gly His Val Val Leu Arg Trp Leu 
    130                 135                 140                 


Pro Pro Pro Gly Ala Pro Val Ala Ser Leu Ile Arg Tyr Glu Val Asn 
145                 150                 155                 160 


Ile Ser Ser Gly Asn Val Ala Gly Gly Ala Gln Lys Val Glu Ile Leu 
                165                 170                 175     


Asp Gly Arg Thr Glu Cys Ala Leu Ser Asn Leu Arg Gly Arg Thr Arg 
            180                 185                 190         


Tyr Thr Phe Met Val Arg Ala Arg Met Ala Glu Pro Ser Phe Gly Gly 
        195                 200                 205             


Phe Trp Ser Ala Trp Ser Glu Pro Ala Ser Leu Leu Thr Ala Ser Asp 
    210                 215                 220                 


Leu Asp 
225     


<210>  43
<211>  215
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(215)
<223>  Exemplary Feline EPOR201 minimal ECD

<400>  43

Asp Pro Lys Phe Glu Ser Lys Val Asn Met Val Cys Met Arg Ala Pro 
1               5                   10                  15      


Glu Ala Ser Ala Cys Gly Ser Ser Glu Arg Leu Glu Asp Leu Val Cys 
            20                  25                  30          


Phe Trp Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr Ser 
        35                  40                  45              


Phe Phe Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Ser Leu His 
    50                  55                  60                  


Gln Ala Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro 
65                  70                  75                  80  


Thr Ala Asp Ala Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala 
                85                  90                  95      


Val Ser Ser Gly Ala Pro Arg Tyr His Arg Ile Ile His Ile Asn Glu 
            100                 105                 110         


Val Val Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala Asp 
        115                 120                 125             


Glu Gly Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro 
    130                 135                 140                 


Val Ala Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ser Gly Asn Val 
145                 150                 155                 160 


Ala Gly Gly Ala Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu Cys 
                165                 170                 175     


Ala Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Met Val Arg 
            180                 185                 190         


Ala Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser 
        195                 200                 205             


Glu Pro Ala Ser Leu Leu Thr 
    210                 215 


<210>  44
<211>  511
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(511)
<223>  Felis catus  EPO receptor Sequence EPOR202

<400>  44

Met Asp His Leu Trp Ala Pro Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Pro Leu Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Gly Lys Asp Gly Ser Val Cys Arg Pro Pro 
        35                  40                  45              


Gln Trp Phe Leu Glu Gly Asn Ala Glu Glu Arg Leu Glu Asp Leu Val 
    50                  55                  60                  


Cys Phe Trp Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr 
65                  70                  75                  80  


Ser Phe Phe Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Ser Leu 
                85                  90                  95      


His Gln Ala Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu 
            100                 105                 110         


Pro Thr Ala Asp Ala Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr 
        115                 120                 125             


Ala Val Ser Ser Gly Ala Pro Arg Tyr His Arg Ile Ile His Ile Asn 
    130                 135                 140                 


Glu Val Val Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala 
145                 150                 155                 160 


Asp Glu Gly Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala 
                165                 170                 175     


Pro Val Ala Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ser Gly Asn 
            180                 185                 190         


Val Ala Gly Gly Ala Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu 
        195                 200                 205             


Cys Ala Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Met Val 
    210                 215                 220                 


Arg Ala Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp 
225                 230                 235                 240 


Ser Glu Pro Ala Ser Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Ile 
                245                 250                 255     


Leu Thr Leu Ser Leu Ile Leu Val Leu Ile Leu Leu Leu Leu Ala Val 
            260                 265                 270         


Leu Ala Leu Leu Ser His Arg Arg Thr Leu Lys Gln Lys Ile Trp Pro 
        275                 280                 285             


Gly Ile Pro Ser Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His 
    290                 295                 300                 


Lys Gly Asn Phe Gln Leu Trp Leu Tyr Gln Asn Glu Gly Cys Leu Trp 
305                 310                 315                 320 


Trp Ser Pro Cys Ala Pro Phe Ala Glu Asp Pro Pro Ser Pro Leu Glu 
                325                 330                 335     


Val Leu Ser Glu Arg Cys Trp Gly Ala Thr Gln Ala Ala Glu Pro Gly 
            340                 345                 350         


Ala Glu Glu Gly Pro Leu Leu Glu Pro Leu Gly Ser Glu His Thr Gln 
        355                 360                 365             


Asp Thr Tyr Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro 
    370                 375                 380                 


Ser Glu Asp Leu Pro Arg Pro Asp Gly Ser Leu Asp Met Val Ala Met 
385                 390                 395                 400 


His Lys Gly Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ser Leu Lys 
                405                 410                 415     


Pro Gly Pro Glu Gly Ala Leu Gly Ala Ser Phe Glu Tyr Thr Ile Leu 
            420                 425                 430         


Asp Pro Ser Ser Gln Leu Leu Arg Pro Arg Ala Leu Pro Pro Glu Leu 
        435                 440                 445             


Pro Pro Thr Pro Pro His Ile Lys Tyr Leu Tyr Leu Met Val Ser Asp 
    450                 455                 460                 


Ser Gly Ile Ser Thr Asp Tyr Ser Ser Gly Gly Ser Gln Glu Ala Gln 
465                 470                 475                 480 


Gly Asp Ser Ser Thr Gly Pro Tyr Leu Asn Pro Tyr Glu Asn Ser Leu 
                485                 490                 495     


Ile Pro Ala Thr Glu Thr Ser Pro Pro Ser Tyr Val Ala Cys Ser 
            500                 505                 510     


<210>  45
<211>  228
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(228)
<223>  Exemplary feline EPOR202 ECD

<400>  45

Pro Pro Pro Asn Pro Leu Asp Pro Lys Phe Glu Ser Lys Gly Lys Asp 
1               5                   10                  15      


Gly Ser Val Cys Arg Pro Pro Gln Trp Phe Leu Glu Gly Asn Ala Glu 
            20                  25                  30          


Glu Arg Leu Glu Asp Leu Val Cys Phe Trp Glu Glu Ala Ala Ser Ala 
        35                  40                  45              


Gly Val Gly Pro Asp Asn Tyr Ser Phe Phe Tyr Gln Leu Glu Gly Glu 
    50                  55                  60                  


Pro Trp Lys Pro Cys Ser Leu His Gln Ala Pro Thr Ala Arg Gly Ala 
65                  70                  75                  80  


Val Arg Phe Trp Cys Ser Leu Pro Thr Ala Asp Ala Ser Ser Phe Val 
                85                  90                  95      


Pro Leu Glu Leu Arg Val Thr Ala Val Ser Ser Gly Ala Pro Arg Tyr 
            100                 105                 110         


His Arg Ile Ile His Ile Asn Glu Val Val Leu Leu Asp Pro Pro Ala 
        115                 120                 125             


Gly Leu Leu Ala Arg Arg Ala Asp Glu Gly Gly His Val Val Leu Arg 
    130                 135                 140                 


Trp Leu Pro Pro Pro Gly Ala Pro Val Ala Ser Leu Ile Arg Tyr Glu 
145                 150                 155                 160 


Val Asn Ile Ser Ser Gly Asn Val Ala Gly Gly Ala Gln Lys Val Glu 
                165                 170                 175     


Ile Leu Asp Gly Arg Thr Glu Cys Ala Leu Ser Asn Leu Arg Gly Arg 
            180                 185                 190         


Thr Arg Tyr Thr Phe Met Val Arg Ala Arg Met Ala Glu Pro Ser Phe 
        195                 200                 205             


Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Ala Ser Leu Leu Thr Ala 
    210                 215                 220                 


Ser Asp Leu Asp 
225             


<210>  46
<211>  217
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(217)
<223>  Exemplary feline EPOR202 minimal ECD

<400>  46

Asp Pro Lys Phe Glu Ser Lys Gly Lys Asp Gly Ser Val Cys Arg Pro 
1               5                   10                  15      


Pro Gln Trp Phe Leu Glu Gly Asn Ala Glu Glu Arg Leu Glu Asp Leu 
            20                  25                  30          


Val Cys Phe Trp Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn 
        35                  40                  45              


Tyr Ser Phe Phe Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Ser 
    50                  55                  60                  


Leu His Gln Ala Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser 
65                  70                  75                  80  


Leu Pro Thr Ala Asp Ala Ser Ser Phe Val Pro Leu Glu Leu Arg Val 
                85                  90                  95      


Thr Ala Val Ser Ser Gly Ala Pro Arg Tyr His Arg Ile Ile His Ile 
            100                 105                 110         


Asn Glu Val Val Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg 
        115                 120                 125             


Ala Asp Glu Gly Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly 
    130                 135                 140                 


Ala Pro Val Ala Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ser Gly 
145                 150                 155                 160 


Asn Val Ala Gly Gly Ala Gln Lys Val Glu Ile Leu Asp Gly Arg Thr 
                165                 170                 175     


Glu Cys Ala Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Met 
            180                 185                 190         


Val Arg Ala Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala 
        195                 200                 205             


Trp Ser Glu Pro Ala Ser Leu Leu Thr 
    210                 215         


<210>  47
<211>  508
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(508)
<223>  Felis catus  EPO receptor Sequence EPOR203

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Met Asp His Leu Trp Ala Pro Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Pro Leu Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Xaa Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr Ser Phe Phe 
65                  70                  75                  80  


Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Ser Leu His Gln Ala 
                85                  90                  95      


Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Ala Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Val Ser 
        115                 120                 125             


Ser Gly Ala Pro Arg Tyr His Arg Ile Ile His Ile Asn Glu Val Val 
    130                 135                 140                 


Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala Asp Glu Gly 
145                 150                 155                 160 


Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Val Ala 
                165                 170                 175     


Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ser Gly Asn Val Ala Gly 
            180                 185                 190         


Gly Ala Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Ala Leu 
        195                 200                 205             


Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Met Val Arg Ala Arg 
    210                 215                 220                 


Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro 
225                 230                 235                 240 


Ala Ser Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu 
                245                 250                 255     


Ser Leu Ile Leu Val Leu Ile Leu Leu Leu Leu Ala Val Leu Ala Leu 
            260                 265                 270         


Leu Ser His Arg Arg Thr Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro 
        275                 280                 285             


Ser Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn 
    290                 295                 300                 


Phe Gln Leu Trp Leu Tyr Gln Asn Glu Gly Cys Leu Trp Trp Ser Pro 
305                 310                 315                 320 


Cys Ala Pro Phe Ala Glu Asp Pro Pro Ser Pro Leu Glu Val Leu Ser 
                325                 330                 335     


Glu Arg Cys Trp Gly Ala Thr Gln Ala Ala Glu Pro Gly Ala Glu Glu 
            340                 345                 350         


Gly Pro Leu Leu Glu Pro Leu Gly Ser Glu His Thr Gln Asp Thr Tyr 
        355                 360                 365             


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
    370                 375                 380                 


Leu Pro Arg Pro Asp Gly Ser Leu Asp Met Val Ala Met His Lys Gly 
385                 390                 395                 400 


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ser Leu Lys Pro Gly Pro 
                405                 410                 415     


Glu Gly Ala Leu Gly Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
            420                 425                 430         


Ser Gln Leu Leu Arg Pro Arg Ala Leu Pro Pro Glu Leu Pro Pro Thr 
        435                 440                 445             


Pro Pro His Ile Lys Tyr Leu Tyr Leu Met Val Ser Asp Ser Gly Ile 
    450                 455                 460                 


Ser Thr Asp Tyr Ser Ser Gly Gly Ser Gln Glu Ala Gln Gly Asp Ser 
465                 470                 475                 480 


Ser Thr Gly Pro Tyr Leu Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
                485                 490                 495     


Thr Glu Thr Ser Pro Pro Ser Tyr Val Ala Cys Ser 
            500                 505             


<210>  48
<211>  226
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(226)
<223>  Exemplary feline EPOR203 ECD

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  48

Pro Pro Pro Asn Pro Leu Asp Pro Lys Phe Glu Ser Lys Xaa Ala Leu 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Glu Glu Leu Leu Cys Phe Thr Glu Arg Leu 
            20                  25                  30          


Glu Asp Leu Val Cys Phe Trp Glu Glu Ala Ala Ser Ala Gly Val Gly 
        35                  40                  45              


Pro Asp Asn Tyr Ser Phe Phe Tyr Gln Leu Glu Gly Glu Pro Trp Lys 
    50                  55                  60                  


Pro Cys Ser Leu His Gln Ala Pro Thr Ala Arg Gly Ala Val Arg Phe 
65                  70                  75                  80  


Trp Cys Ser Leu Pro Thr Ala Asp Ala Ser Ser Phe Val Pro Leu Glu 
                85                  90                  95      


Leu Arg Val Thr Ala Val Ser Ser Gly Ala Pro Arg Tyr His Arg Ile 
            100                 105                 110         


Ile His Ile Asn Glu Val Val Leu Leu Asp Pro Pro Ala Gly Leu Leu 
        115                 120                 125             


Ala Arg Arg Ala Asp Glu Gly Gly His Val Val Leu Arg Trp Leu Pro 
    130                 135                 140                 


Pro Pro Gly Ala Pro Val Ala Ser Leu Ile Arg Tyr Glu Val Asn Ile 
145                 150                 155                 160 


Ser Ser Gly Asn Val Ala Gly Gly Ala Gln Lys Val Glu Ile Leu Asp 
                165                 170                 175     


Gly Arg Thr Glu Cys Ala Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr 
            180                 185                 190         


Thr Phe Met Val Arg Ala Arg Met Ala Glu Pro Ser Phe Gly Gly Phe 
        195                 200                 205             


Trp Ser Ala Trp Ser Glu Pro Ala Ser Leu Leu Thr Ala Ser Asp Leu 
    210                 215                 220                 


Asp Pro 
225     


<210>  49
<211>  214
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(214)
<223>  Exemplary feline EPOR203_39A minimal ECD

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Asp Pro Lys Phe Glu Ser Lys Xaa Ala Leu Leu Ala Ala Arg Gly Pro 
1               5                   10                  15      


Glu Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe 
            20                  25                  30          


Trp Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr Ser Phe 
        35                  40                  45              


Phe Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Ser Leu His Gln 
    50                  55                  60                  


Ala Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr 
65                  70                  75                  80  


Ala Asp Ala Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Val 
                85                  90                  95      


Ser Ser Gly Ala Pro Arg Tyr His Arg Ile Ile His Ile Asn Glu Val 
            100                 105                 110         


Val Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala Asp Glu 
        115                 120                 125             


Gly Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Val 
    130                 135                 140                 


Ala Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ser Gly Asn Val Ala 
145                 150                 155                 160 


Gly Gly Ala Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Ala 
                165                 170                 175     


Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Met Val Arg Ala 
            180                 185                 190         


Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu 
        195                 200                 205             


Pro Ala Ser Leu Leu Thr 
    210                 


<210>  50
<211>  508
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(508)
<223>  Exemplary feline EPO receptor EPOR203_39A

<400>  50

Met Asp His Leu Trp Ala Pro Leu Trp Pro Gly Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Pro Leu Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr Ser Phe Phe 
65                  70                  75                  80  


Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Ser Leu His Gln Ala 
                85                  90                  95      


Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Ala Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Val Ser 
        115                 120                 125             


Ser Gly Ala Pro Arg Tyr His Arg Ile Ile His Ile Asn Glu Val Val 
    130                 135                 140                 


Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala Asp Glu Gly 
145                 150                 155                 160 


Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Val Ala 
                165                 170                 175     


Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ser Gly Asn Val Ala Gly 
            180                 185                 190         


Gly Ala Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Ala Leu 
        195                 200                 205             


Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Met Val Arg Ala Arg 
    210                 215                 220                 


Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro 
225                 230                 235                 240 


Ala Ser Leu Leu Thr Ala Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu 
                245                 250                 255     


Ser Leu Ile Leu Val Leu Ile Leu Leu Leu Leu Ala Val Leu Ala Leu 
            260                 265                 270         


Leu Ser His Arg Arg Thr Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro 
        275                 280                 285             


Ser Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn 
    290                 295                 300                 


Phe Gln Leu Trp Leu Tyr Gln Asn Glu Gly Cys Leu Trp Trp Ser Pro 
305                 310                 315                 320 


Cys Ala Pro Phe Ala Glu Asp Pro Pro Ser Pro Leu Glu Val Leu Ser 
                325                 330                 335     


Glu Arg Cys Trp Gly Ala Thr Gln Ala Ala Glu Pro Gly Ala Glu Glu 
            340                 345                 350         


Gly Pro Leu Leu Glu Pro Leu Gly Ser Glu His Thr Gln Asp Thr Tyr 
        355                 360                 365             


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
    370                 375                 380                 


Leu Pro Arg Pro Asp Gly Ser Leu Asp Met Val Ala Met His Lys Gly 
385                 390                 395                 400 


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ser Leu Lys Pro Gly Pro 
                405                 410                 415     


Glu Gly Ala Leu Gly Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
            420                 425                 430         


Ser Gln Leu Leu Arg Pro Arg Ala Leu Pro Pro Glu Leu Pro Pro Thr 
        435                 440                 445             


Pro Pro His Ile Lys Tyr Leu Tyr Leu Met Val Ser Asp Ser Gly Ile 
    450                 455                 460                 


Ser Thr Asp Tyr Ser Ser Gly Gly Ser Gln Glu Ala Gln Gly Asp Ser 
465                 470                 475                 480 


Ser Thr Gly Pro Tyr Leu Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
                485                 490                 495     


Thr Glu Thr Ser Pro Pro Ser Tyr Val Ala Cys Ser 
            500                 505             


<210>  51
<211>  226
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(226)
<223>  Exemplary feline EPOR203_39A ECD

<400>  51

Pro Pro Pro Asn Pro Leu Asp Pro Lys Phe Glu Ser Lys Ala Ala Leu 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Glu Glu Leu Leu Cys Phe Thr Glu Arg Leu 
            20                  25                  30          


Glu Asp Leu Val Cys Phe Trp Glu Glu Ala Ala Ser Ala Gly Val Gly 
        35                  40                  45              


Pro Asp Asn Tyr Ser Phe Phe Tyr Gln Leu Glu Gly Glu Pro Trp Lys 
    50                  55                  60                  


Pro Cys Ser Leu His Gln Ala Pro Thr Ala Arg Gly Ala Val Arg Phe 
65                  70                  75                  80  


Trp Cys Ser Leu Pro Thr Ala Asp Ala Ser Ser Phe Val Pro Leu Glu 
                85                  90                  95      


Leu Arg Val Thr Ala Val Ser Ser Gly Ala Pro Arg Tyr His Arg Ile 
            100                 105                 110         


Ile His Ile Asn Glu Val Val Leu Leu Asp Pro Pro Ala Gly Leu Leu 
        115                 120                 125             


Ala Arg Arg Ala Asp Glu Gly Gly His Val Val Leu Arg Trp Leu Pro 
    130                 135                 140                 


Pro Pro Gly Ala Pro Val Ala Ser Leu Ile Arg Tyr Glu Val Asn Ile 
145                 150                 155                 160 


Ser Ser Gly Asn Val Ala Gly Gly Ala Gln Lys Val Glu Ile Leu Asp 
                165                 170                 175     


Gly Arg Thr Glu Cys Ala Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr 
            180                 185                 190         


Thr Phe Met Val Arg Ala Arg Met Ala Glu Pro Ser Phe Gly Gly Phe 
        195                 200                 205             


Trp Ser Ala Trp Ser Glu Pro Ala Ser Leu Leu Thr Ala Ser Asp Leu 
    210                 215                 220                 


Asp Pro 
225     


<210>  52
<211>  214
<212>  PRT
<213>  Felis catus


<220>
<221>  misc_feature
<222>  (1)..(214)
<223>  Exemplary feline EPOR203_39A minimal ECD

<400>  52

Asp Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro 
1               5                   10                  15      


Glu Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe 
            20                  25                  30          


Trp Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Asp Asn Tyr Ser Phe 
        35                  40                  45              


Phe Tyr Gln Leu Glu Gly Glu Pro Trp Lys Pro Cys Ser Leu His Gln 
    50                  55                  60                  


Ala Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr 
65                  70                  75                  80  


Ala Asp Ala Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Val 
                85                  90                  95      


Ser Ser Gly Ala Pro Arg Tyr His Arg Ile Ile His Ile Asn Glu Val 
            100                 105                 110         


Val Leu Leu Asp Pro Pro Ala Gly Leu Leu Ala Arg Arg Ala Asp Glu 
        115                 120                 125             


Gly Gly His Val Val Leu Arg Trp Leu Pro Pro Pro Gly Ala Pro Val 
    130                 135                 140                 


Ala Ser Leu Ile Arg Tyr Glu Val Asn Ile Ser Ser Gly Asn Val Ala 
145                 150                 155                 160 


Gly Gly Ala Gln Lys Val Glu Ile Leu Asp Gly Arg Thr Glu Cys Ala 
                165                 170                 175     


Leu Ser Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Met Val Arg Ala 
            180                 185                 190         


Arg Met Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu 
        195                 200                 205             


Pro Ala Ser Leu Leu Thr 
    210                 


<210>  53
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-A Fc   Protein A  C1q 
       CD16

<400>  53

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  54
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-B Fc   Protein A + C1q 
       + CD16 +

<400>  54

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  55
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-B Fc with hinge Protein
       A + C1q + CD16 +

<400>  55

Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser 
    50                  55                  60                  


Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn 
            100                 105                 110         


Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg 
        115                 120                 125             


Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe 
145                 150                 155                 160 


Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
                165                 170                 175     


Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly 
            180                 185                 190         


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
225                 230                 235         


<210>  56
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-C Fc   Protein A   C1q 
       + CD16 +

<400>  56

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  57
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-C Fc with hinge Protein
       A   C1q + CD16 +

<400>  57

Ala Lys Glu Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro 
1               5                   10                  15      


Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
                85                  90                  95      


Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln 
        115                 120                 125             


Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met 
    130                 135                 140                 


Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro 
145                 150                 155                 160 


Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
                165                 170                 175     


Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
        195                 200                 205             


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
225                 230                 235 


<210>  58
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type canine IgG-D Fc   Protein A  C1q 
       CD16

<400>  58

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu Gln Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  59
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-A Fc   C1q  Protein A + 
       I(21)T R(23)L T(25)A E(80)G T(205)A Q(207)H

<400>  59

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  60
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc   C1q + Protein A + 
       I(21)T V(23)L T(24)I

<400>  60

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  61
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-D Fc   C1q  Protein A + 
       I(21)T R(23)L T(25)A E(80)G Q(207)H

<400>  61

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  62
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-A Fc   C1q  Protein A + 
       I(21)T Q(207)H

<400>  62

Pro Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Arg Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
145                 150                 155                 160 


Pro Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  63
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc   C1q + Protein A + 
       I(21)T

<400>  63

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  64
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-D Fc   C1q  Protein A + 
       I(21)T Q(207)H

<400>  64

Pro Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys 
            20                  25                  30          


Val Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Gln Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu 
65                  70                  75                  80  


His Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu 
        115                 120                 125             


Leu Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe 
    130                 135                 140                 


Phe Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Pro Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly 
                165                 170                 175     


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220     


<210>  65
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q 
       K(93)R

<400>  65

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  66
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q CD16
       + K(93)R

<400>  66

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  67
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   M(5)P

<400>  67

Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  68
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   P(39)R

<400>  68

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  69
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   D(38)G

<400>  69

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  70
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   D(38)G P(39)R

<400>  70

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  71
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   K(97)I

<400>  71

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  72
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   A(98)G

<400>  72

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  73
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16  D(38)G  K(97)I A(98)G

<400>  73

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  74
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q + 
       CD16   M(5)P P(39)R

<400>  74

Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  75
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q + 
       CD16   L(5)P

<400>  75

Pro Gly Cys Gly Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  76
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q + 
       CD16   P(39)R

<400>  76

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  77
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q + 
       CD16   D(38)G

<400>  77

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  78
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q + 
       CD16   K(97)I

<400>  78

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  79
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q + 
       CD16   A(98)G

<400>  79

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Gly Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  80
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q + 
       CD16   L(5)P P(39)R

<400>  80

Pro Gly Cys Gly Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  81
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q + 
       CD16  D(38)G  K(97)I A(98)G

<400>  81

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  82
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc   C1q    K(93)R 
       Protein A + I(21)T V(23)L T(24)I

<400>  82

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  83
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A +  C1q 
       CD16  D(38)G  K(93)R K(97)I A(98)G

<400>  83

Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  84
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-B Fc  Protein A + C1q 
       CD16  M(5)P P(39)R K(93)R

<400>  84

Pro Ala Pro Glu Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asp Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly 
            100                 105                 110         


Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  85
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q CD16
       D(38)G  K(93)R K(97)I A(98)G

<400>  85

Pro Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Gly Pro Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Ile Gly Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  86
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant canine IgG-C Fc  Protein A  C1q CD16
       M(5)P P(39)R K(93)R

<400>  86

Pro Gly Cys Gly Pro Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Leu Asp Arg Glu Asn Pro Glu Val Gln Ile Ser Trp 
        35                  40                  45              


Phe Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu 
    50                  55                  60                  


Glu Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly 
65                  70                  75                  80  


His Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Arg Val Asn Asn 
                85                  90                  95      


Lys Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly 
            100                 105                 110         


Gln Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu 
        115                 120                 125             


Met Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg 
            180                 185                 190         


Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  87
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG1 Fc   Protein A + C1q +

<400>  87

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Met Asp Gly Val Glu 
        35                  40                  45              


Val Arg Thr Ala Thr Thr Arg Pro Lys Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Gln Pro 
                85                  90                  95      


Ile Glu Arg Thr Ile Thr Lys Thr Lys Gly Arg Ser Gln Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Ser Lys Lys Ser Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asn Ile 
    130                 135                 140                 


Glu Trp Gln Ser Asn Gly Gln Pro Glu Leu Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Gln Ala Gln Gln Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Val Asp Arg Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Gly Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Asn Val 
        195                 200                 205             


Ser Lys Asn Pro Gly Lys 
    210                 


<210>  88
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG2 Fc  Protein A  C1q

<400>  88

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser 
            20                  25                  30          


Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu 
        35                  40                  45              


Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro 
                85                  90                  95      


Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile 
        195                 200                 205             


Ser Glu Ser Leu Gly Lys 
    210                 


<210>  89
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG2 Fc with hinge  Protein
       A  C1q

<400>  89

Pro Pro Cys Val Leu Ser Ala Glu Gly Val Ile Pro Ile Pro Ser Val 
1               5                   10                  15      


Pro Lys Pro Gln Cys Pro Pro Tyr Thr His Ser Lys Phe Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser Asp Gln 
    50                  55                  60                  


Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu Val His 
65                  70                  75                  80  


Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser Gly Lys 
            100                 105                 110         


Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro Ile Ser 
        115                 120                 125             


Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln Val Tyr 
    130                 135                 140                 


Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val Ser Val 
145                 150                 155                 160 


Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val Glu Trp 
                165                 170                 175     


Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr Thr Pro 
            180                 185                 190         


Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
        195                 200                 205             


Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys Ala Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Phe Thr Lys Thr Asp Ile Ser Glu 
225                 230                 235                 240 


Ser Leu Gly Lys 
                


<210>  90
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG3 Fc  Protein A + C1q+

<400>  90

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Thr Arg Met Pro Glu Val Thr Cys Leu Val Val Asp Val Ser 
            20                  25                  30          


His Asp Ser Ser Asp Val Leu Phe Thr Trp Tyr Val Asp Gly Thr Glu 
        35                  40                  45              


Val Lys Thr Ala Lys Thr Met Pro Asn Glu Glu Gln Asn Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Lys Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Lys Ala Thr Gly Gln Thr Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Thr Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Arg Thr 
145                 150                 155                 160 


Thr Glu Ala Gln Lys Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Lys Asp Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Val Val Met His Glu Ala Leu His Asn His Val Met Gln Lys Asn Ile 
        195                 200                 205             


Ser Lys Asn Pro Gly Lys 
    210                 


<210>  91
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG4 Fc  Protein A + C1q +

<400>  91

Val Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly 
            20                  25                  30          


His Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Lys Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Ala Pro Thr Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Arg Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile 
    130                 135                 140                 


Glu Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val 
        195                 200                 205             


Ser Lys Ser Pro Gly Lys 
    210                 


<210>  92
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG5 Fc  Protein A  C1q

<400>  92

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Lys Pro Glu Val Thr Cys Val Val Val Asp Leu Gly 
            20                  25                  30          


His Asp Asp Pro Asp Val Gln Phe Thr Trp Phe Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Thr Ser Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Leu Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ala Lys Asn Thr Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asn Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Val Glu Thr Ser Arg Trp Lys Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Gly Val Met His Glu Ala Val Glu Asn His Tyr Thr Gln Lys Asn Val 
        195                 200                 205             


Ser His Ser Pro Gly Lys 
    210                 


<210>  93
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG6 Fc  Protein A  C1q

<400>  93

Gly Arg Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Ala His Thr Ala Thr Thr Lys Ala Lys Glu Lys Gln Asp Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Arg Arg 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Thr Lys Ala Lys Gly Glu Leu Gln Asp Pro Gln 
            100                 105                 110         


Val Tyr Ile Leu Ala Pro His Pro Asp Glu Val Thr Lys Asn Thr Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asn Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu Glu Pro Glu Pro Glu Val Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asp Arg Trp Glu Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Val Val Met His Glu Ala Ile Arg His Thr Tyr Arg Gln Lys Ser Ile 
        195                 200                 205             


Thr Asn Phe Pro Gly Lys 
    210                 


<210>  94
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type equine IgG7 Fc  Protein A + C1q +

<400>  94

Val Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly 
            20                  25                  30          


His Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Asn Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Ile Leu Ala Ile Gln His Lys Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Gln Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Gln Lys Thr Ile Ser Lys Pro Thr Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile 
    130                 135                 140                 


Glu Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val 
        195                 200                 205             


Ser Lys Ser Pro Gly Lys 
    210                 


<210>  95
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc  C1q  Protein A + 
       F(203)Y

<400>  95

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Ala Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser 
            20                  25                  30          


Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu 
        35                  40                  45              


Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro 
                85                  90                  95      


Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile 
        195                 200                 205             


Ser Glu Ser Leu Gly Lys 
    210                 


<210>  96
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG2 Fc  C1q  Protein A + 
       A(15)T F(203)Y

<400>  96

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Val Val Thr Cys Val Val Val Asn Leu Ser 
            20                  25                  30          


Asp Gln Tyr Pro Asp Val Gln Phe Ser Trp Tyr Val Asp Asn Thr Glu 
        35                  40                  45              


Val His Ser Ala Ile Thr Lys Gln Arg Glu Ala Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Thr Asn Val Gly Val Pro Gln Pro 
                85                  90                  95      


Ile Ser Arg Ala Ile Ser Arg Gly Lys Gly Pro Ser Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Pro Pro His Pro Asp Glu Leu Ala Lys Ser Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Ser Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Arg Trp Pro Glu Leu Glu Gly Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Leu Glu Thr Ser Arg Trp Gln Gln Val Glu Ser Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Lys Thr Asp Ile 
        195                 200                 205             


Ser Glu Ser Leu Gly Lys 
    210                 


<210>  97
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG5 Fc  C1q  Protein A + 
       V(199)L E(200)H

<400>  97

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Lys Pro Glu Val Thr Cys Val Val Val Asp Leu Gly 
            20                  25                  30          


His Asp Asp Pro Asp Val Gln Phe Thr Trp Phe Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Thr Ser Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Leu Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ala Lys Asn Thr Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asp Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asn Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Val Glu Thr Ser Arg Trp Lys Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Gly Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Asn Val 
        195                 200                 205             


Ser His Ser Pro Gly Lys 
    210                 


<210>  98
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG6 Fc  C1q  Protein A + 
       I(199)L  R(200)H H(201)N T(202)H

<400>  98

Gly Arg Pro Ser Val Phe Ile Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Ala His Thr Ala Thr Thr Lys Ala Lys Glu Lys Gln Asp Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Gln Asp Trp Arg Arg 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Thr Lys Ala Lys Gly Glu Leu Gln Asp Pro Gln 
            100                 105                 110         


Val Tyr Ile Leu Ala Pro His Pro Asp Glu Val Thr Lys Asn Thr Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asn Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu Glu Pro Glu Pro Glu Val Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asp Arg Trp Glu Gln Gly Glu Ser Phe Thr Cys 
            180                 185                 190         


Val Val Met His Glu Ala Leu His Asn His Tyr Arg Gln Lys Ser Ile 
        195                 200                 205             


Thr Asn Phe Pro Gly Lys 
    210                 


<210>  99
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG1 Fc   Protein A + C1q 
       K(87)S

<400>  99

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Asn Pro Lys Asp Thr Leu 
1               5                   10                  15      


Met Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            20                  25                  30          


Gln Glu Asn Pro Asp Val Lys Phe Asn Trp Tyr Met Asp Gly Val Glu 
        35                  40                  45              


Val Arg Thr Ala Thr Thr Arg Pro Lys Glu Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Asn Asn Gln Ala Leu Pro Gln Pro 
                85                  90                  95      


Ile Glu Arg Thr Ile Thr Lys Thr Lys Gly Arg Ser Gln Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Ser Lys Lys Ser Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Glu Ile Asn Ile 
    130                 135                 140                 


Glu Trp Gln Ser Asn Gly Gln Pro Glu Leu Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Gln Ala Gln Gln Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Ser Val Asp Arg Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Gly Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Asn Val 
        195                 200                 205             


Ser Lys Asn Pro Gly Lys 
    210                 


<210>  100
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG3 Fc  Protein A + C1q 
       K(87)S

<400>  100

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Thr Arg Met Pro Glu Val Thr Cys Leu Val Val Asp Val Ser 
            20                  25                  30          


His Asp Ser Ser Asp Val Leu Phe Thr Trp Tyr Val Asp Gly Thr Glu 
        35                  40                  45              


Val Lys Thr Ala Lys Thr Met Pro Asn Glu Glu Gln Asn Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Arg Ile Gln His Gln Asp Trp Leu Asn 
65                  70                  75                  80  


Gly Lys Lys Phe Lys Cys Ser Val Asn Asn Gln Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Lys Ala Thr Gly Gln Thr Arg Val Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Thr Val 
    130                 135                 140                 


Glu Trp Gln Ser Asn Glu His Pro Glu Pro Glu Gly Lys Tyr Arg Thr 
145                 150                 155                 160 


Thr Glu Ala Gln Lys Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Lys Asp Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Val Val Met His Glu Ala Leu His Asn His Val Met Gln Lys Asn Ile 
        195                 200                 205             


Ser Lys Asn Pro Gly Lys 
    210                 


<210>  101
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG4 Fc  Protein A + C1q 
       K(87)S

<400>  101

Val Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly 
            20                  25                  30          


His Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Phe Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Val Leu Pro Ile Gln His Lys Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Asn Asn Lys Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Glu Arg Thr Ile Ser Ala Pro Thr Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Arg Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile 
    130                 135                 140                 


Glu Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val 
        195                 200                 205             


Ser Lys Ser Pro Gly Lys 
    210                 


<210>  102
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant equine IgG7 Fc  Protein A + C1q 
       K(87)S

<400>  102

Val Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
1               5                   10                  15      


Met Ile Ser Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Val Gly 
            20                  25                  30          


His Asp Phe Pro Asp Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        35                  40                  45              


Thr His Thr Ala Thr Thr Glu Pro Lys Gln Glu Gln Asn Asn Ser Thr 
    50                  55                  60                  


Tyr Arg Val Val Ser Ile Leu Ala Ile Gln His Lys Asp Trp Leu Ser 
65                  70                  75                  80  


Gly Lys Glu Phe Lys Cys Ser Val Asn Asn Gln Ala Leu Pro Ala Pro 
                85                  90                  95      


Val Gln Lys Thr Ile Ser Lys Pro Thr Gly Gln Pro Arg Glu Pro Gln 
            100                 105                 110         


Val Tyr Val Leu Ala Pro His Pro Asp Glu Leu Ser Lys Asn Lys Val 
        115                 120                 125             


Ser Val Thr Cys Leu Val Lys Asp Phe Tyr Pro Pro Asp Ile Asp Ile 
    130                 135                 140                 


Glu Trp Lys Ser Asn Gly Gln Pro Glu Pro Glu Thr Lys Tyr Ser Thr 
145                 150                 155                 160 


Thr Pro Ala Gln Leu Asp Gly Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                165                 170                 175     


Leu Thr Val Glu Thr Asn Arg Trp Gln Gln Gly Thr Thr Phe Thr Cys 
            180                 185                 190         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Glu Lys Ser Val 
        195                 200                 205             


Ser Lys Ser Pro Gly Lys 
    210                 


<210>  103
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1a Fc  Protein A + C1q +

<400>  103

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  104
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1a Fc  Protein A + C1q +

<400>  104

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  105
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1b Fc  Protein A + C1q +

<400>  105

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  106
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG1b Fc  Protein A + C1q +

<400>  106

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  107
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary wild-type feline IgG2 Fc  Protein A + C1q

<400>  107

Pro Lys Thr Ala Ser Thr Ile Glu Ser Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Val Pro Glu Ile Pro Gly Ala Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asn Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Glu Met His Thr Ala Lys Thr Arg Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Ala Met Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Thr Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Gly Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Gln Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  108
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc  Protein A + C1q 
       P(198)A

<400>  108

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  109
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1a Fc  Protein A + C1q 
       P(198)A

<400>  109

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe 
145                 150                 155                 160 


His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  110
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc  Protein A + C1q 
       P(198)A

<400>  110

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  111
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant feline IgG1b Fc  Protein A + C1q 
       P(198)A

<400>  111

Arg Lys Thr Asp His Pro Pro Gly Pro Lys Thr Gly Glu Gly Pro Lys 
1               5                   10                  15      


Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr 
    50                  55                  60                  


Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu 
    130                 135                 140                 


Glu Leu Ser Glu Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu 
                165                 170                 175     


Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly 
            180                 185                 190         


Thr Tyr Phe Leu Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser 
    210                 215                 220                 


His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
225                 230                 235         


<210>  112
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO Analog 6-30 EV Precursor

<400>  112

Met Gly Ser Cys Glu Cys Pro Ala Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Asn Glu Thr Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ser Ser Gln 
            100                 105                 110         


Val Asn Glu Thr Leu Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  113
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO Analog 6-30 EV Mature

<400>  113

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Asn Glu Thr 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ser Ser Gln Val Asn Glu Thr Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  114
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO analog 14precursor D81N G83T

<400>  114

Met Gly Ser Cys Glu Cys Pro Ala Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Glu Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asn Val Thr Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ser Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Leu Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  115
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO analog 14 mature D55N G57T

<400>  115

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Glu Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asn Val Thr Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ser Ser Gln Pro Ser Glu Thr Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  116
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO analog 40 precursor L138N A140T

<400>  116

Met Gly Ser Cys Glu Cys Pro Ala Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Glu Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ser Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Leu Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Asn Gly Thr Gln Lys Glu Ala 
    130                 135                 140                 


Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  117
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO analog 40 mature L112N A114T

<400>  117

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Glu Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ser Ser Gln Pro Ser Glu Thr Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Asn 
            100                 105                 110         


Gly Thr Gln Lys Glu Ala Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  118
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO analog 56 precursor L147N P148V 
       E149T

<400>  118

Met Gly Ser Cys Glu Cys Pro Ala Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Glu Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ser Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Leu Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Thr Ser Asn Val Thr Ala Thr Ser Ala Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  119
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO analog 56 mature L121N P122V 
       E123T

<400>  119

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Glu Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ser Ser Gln Pro Ser Glu Thr Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Thr Ser Asn Val Thr Ala Thr Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  120
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO analog 71 precursor P148E E149N

<400>  120

Met Gly Ser Cys Glu Cys Pro Ala Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Glu Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ser Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Leu Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Thr Ser Leu Glu Asn Ala Thr Ser Ala Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Cys Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  121
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO analog 71 mature P122E E123N

<400>  121

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Glu Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ser Ser Gln Pro Ser Glu Thr Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Thr Ser Leu Glu Asn Ala Thr Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Cys Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  122
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO analog precursor C165X


<220>
<221>  misc_feature
<222>  (165)..(165)
<223>  wherein X may be any amino acid other than C, such as S, T, or A

<400>  122

Met Gly Ser Cys Glu Cys Pro Ala Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Leu Leu Pro Leu Gly Leu Pro Val Leu Gly Ala Pro Pro Arg Leu Ile 
            20                  25                  30          


Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile Leu Glu Ala Arg Glu Ala 
        35                  40                  45              


Glu Asn Val Thr Met Gly Cys Ala Glu Gly Cys Ser Phe Ser Glu Asn 
    50                  55                  60                  


Ile Thr Val Pro Asp Thr Lys Val Asn Phe Tyr Thr Trp Lys Arg Met 
65                  70                  75                  80  


Asp Val Gly Gln Gln Ala Val Glu Val Trp Gln Gly Leu Ala Leu Leu 
                85                  90                  95      


Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu Leu Ala Asn Ser Ser Gln 
            100                 105                 110         


Pro Ser Glu Thr Leu Gln Leu His Val Asp Lys Ala Val Ser Ser Leu 
        115                 120                 125             


Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu Gly Ala Gln Lys Glu Ala 
    130                 135                 140                 


Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala Pro Leu Arg Thr Phe Thr 
145                 150                 155                 160 


Val Asp Thr Leu Xaa Lys Leu Phe Arg Ile Tyr Ser Asn Phe Leu Arg 
                165                 170                 175     


Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala Cys Arg Arg Gly Asp Arg 
            180                 185                 190         


<210>  123
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary feline EPO analog mature C139X


<220>
<221>  misc_feature
<222>  (139)..(139)
<223>  X may be any amino acid other than C, such as S, T, or A

<400>  123

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Ile 
1               5                   10                  15      


Leu Glu Ala Arg Glu Ala Glu Asn Val Thr Met Gly Cys Ala Glu Gly 
            20                  25                  30          


Cys Ser Phe Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Thr Trp Lys Arg Met Asp Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Ile Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ser Ser Gln Pro Ser Glu Thr Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Ser Leu Arg Ser Leu Thr Ser Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Thr Ser Leu Pro Glu Ala Thr Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Phe Thr Val Asp Thr Leu Xaa Lys Leu Phe Arg Ile 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Thr Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


