                         SEQUENCE LISTING

<110>  SENGENICS SDN BHD
       NATIONAL UNIVERSITY OF SINGAPORE
 
<120>  DETECTION OF BIOMARKERS FOR NON-SMALL CELL LUNG CANCER

<130>  SP100423WO

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  243
<212>  DNA
<213>  Homo sapiens

<400>  1
atggaatccc ccaagaagaa gaaccagcag ctgaaggtcg gaatcctgca cctgggttcc       60

cgtcagaaga agatccgtat ccagctgcgt tcccagtgcg ctacctggaa ggtcatctgc      120

aagtcctgca tctcccagac ccccggtatc aacctggacc tgggctccgg tgtcaaggtc      180

aagatcatcc ccaaggaaga acactgcaag atgcccgagg ctggcgagga acagccccag      240

gtg                                                                    243


<210>  2
<211>  1200
<212>  DNA
<213>  Homo sapiens

<400>  2
atggggactc ctgcttctgg aaggaaaaga acacctgtga aagaccgatt ttctgcagaa       60

gatgaagctt tgagtaacat tgccagagag gcagaggcaa ggctggcagc aaaacgggct      120

gcccgggcag aagcaagaga tatacgcatg agagaactgg aacgacaaca aaaagagttg      180

gatgaaaaat ctgacaaaca gtatgctgaa aattatacaa gaccttcatc tcgaaattct      240

gcctcagcaa caacccctct aagtggaaac tcatccagac gaggaagtgg ggacaccagc      300

agcttaatag atccagacac ttcattaagt gaattgcggg aatctttgtc tgaagtggaa      360

gaaaaataca agaaagccat ggtttccaat gcacagttag acaatgagaa gaacaatttg      420

atctaccaag tagacacact caaggatgtt attgaagagc aggaggaaca gatggcagaa      480

ttttatagag aaaatgaaga aaaatcaaag gagttagaaa ggcagaaaca tatgtgtagt      540

gtgctgcagc ataagatgga agaacttaaa gaaggcctgc ggcaaagaga tgagcttatt      600

gagaaacatg gcttagttat aatccccgat ggcactccca atggtgatgt cagtcatgaa      660

ccagtggctg gagccatcac tgttgtgtct caggaagctg ctcaggtctt ggagtcagca      720

ggagaagggc cattagatgt aaggctacga aaacttgctg gagagaagga agaactactg      780

tcacagatta gaaaactgaa gcttcagtta gaggaggaac gacagaaatg ctccaggaat      840

gatggcacag tgggtgacct ggcaggactg cagaatggct cagacttgca gttcatcgaa      900

atgcagagag atgccaatag acaaattagc gaatacaaat ttaagctttc aaaagcagaa      960

caggatataa ctaccttgga gcaaagtatt agccggcttg agggacaggt tctgagatat     1020

aaaactgctg ctgagaatgc tgagaaagtt gaagatgaat tgaaagcaga aaaacggaag     1080

ctacaacgag agttacgaac agcactggac aagattgagg agatggagat gaccaacagc     1140

cacctggcca agcggctgga gaagatgaag gccaatagga cagcacttct ggcccagcag     1200


<210>  3
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtcctggc gtggtcgttc cacctaccgt ccccgtcctc gtcgttacgt cgagcccccc       60

gagatgatcg gtcccatgcg tcccgagcag ttctccgacg aggtcgagcc cgctaccccc      120

gaggaaggcg agcctgctac tcagcgtcag gaccccgctg ctgctcaaga gggcgaggac      180

gagggcgctt ccgctggcca gggtcctaag cccgaggctc actcccaaga gcagggtcac      240

ccccagaccg gttgcgagtg cgaggacggt cccgacggtc aagagatgga cccccccaac      300

cctgaggaag tcaagacccc cgaagagggc gaaaagcagt cccagtgc                   348


<210>  4
<211>  1893
<212>  DNA
<213>  Homo sapiens

<400>  4
atgtcccact gggctcccga gtggaagcgt gctgaggcta acccccgtga cctgggcgct       60

tcttgggacg tgcgcggttc ccgtggtagc ggttggagcg gtcccttcgg tcaccaaggt      120

ccccgtgctg ctggttcccg cgagcccccc ctgtgcttca agatcaagaa caacatggtc      180

ggagtggtca tcggttactc cggttccaag atcaaggacc tgcagcactc caccaacacc      240

aagatccaga tcatcaacgg cgagtccgag gctaaggtcc gcatcttcgg caaccgcgag      300

atgaaggcta aggccaaggc tgctatcgag actctgatcc gcaagcaaga gtcctacaac      360

tccgagtcct ccgtggacaa cgctgcttcc cagaccccca tcggtcgtaa cctgggtcgt      420

aacgacatcg tgggcgaggc tgagcccctg tccaactggg accgtatccg cgctgctgtg      480

gtcgagtgcg agaagcgcaa gtgggctgac ctgccccccg tgaagaagaa cttctacatc      540

gagtccaagg ctacctcctg catgtccgag atgcaagtga tcaactggcg caaggaaaac      600

ttcaacatca cttgcgacga cctgaagtcc ggcgagaagc gtctgatccc caagcctacc      660

tgccgtttca aggacgcttt ccagcagtac cccgacctgc tgaagtccat catccgtgtg      720

ggtatcgtga agcccacccc catccagtcc caggcttggc caatcatcct gcagggtatc      780

gacctgatcg tggtggctca gaccggcacc ggcaagaccc tgtcctacct gatgcccggt      840

ttcatccacc tggactccca gcccatctcc cgcgagcagc gtaacggtcc cggcatgctg      900

gtgctgaccc ctacccgtga actggctctg cacgtcgagg ctgagtgctc caagtactcc      960

tacaagggcc tgaagtctat ctgcatctac ggtggtcgta accgtaacgg ccagatcgag     1020

gacatctcca agggtgtcga catcatcatt gctacccccg gtcgtctgaa cgacctgcag     1080

atgaacaact ccgtgaacct gcgttccatc acctacctgg tcatcgacga ggctgacaag     1140

atgctggaca tggagttcga gccccagatc cgcaagatcc tgctggacgt gcgtcccgac     1200

cgtcagaccg tgatgacctc cgctacctgg cccgacaccg tgcgtcagct ggctctgtct     1260

tacctgaagg accccatgat cgtgtacgtg ggcaacctga acctggtggc tgtgaacacc     1320

gtgaagcaga acatcatcgt gaccaccgag aaggaaaaga gggctctgac ccaagagttc     1380

gtcgagaaca tgtcccccaa cgacaaggtc atcatgttcg tgtcccagaa gcacattgct     1440

gacgacctgt cctccgattt caacatccaa ggcatctccg ctgagtccct gcacggcaac     1500

tccgagcagt ccgaccaaga gcgtgctgtc gaggacttca agtccggcaa catcaagatc     1560

ctcatcacca ccgacatcgt gtcccgtggc ctggacctga acgacgtgac ccacgtgtac     1620

aactacgact tcccccgtaa catcgacgtg tacgtgcacc gtgtgggtta catcggtcgc     1680

accggaaaga ccggaacctc cgtgaccctg atcacccagc gcgactccaa gatggctggc     1740

gagctgatca agatcttgga ccgtgctaac cagtccgtgc ccgaggacct ggtggtcatg     1800

gctgagcagt acaagctgaa ccagcagaag cgtcaccgcg agactcgttc ccgcaagccc     1860

ggacagcgtc gcaaggagtt ctacttcctg tcc                                  1893


<210>  5
<211>  1944
<212>  DNA
<213>  Homo sapiens

<400>  5
atgtcccacc acggtggtgc tcccaaggct tccacctggg tggtggcttc ccgtcgttcc       60

tccaccgtgt cccgtgctcc cgagcgtcgt cccgctgagg aactgaaccg taccggtccc      120

gagggctact ccgtgggtcg tggtggtcgt tggcgtggca cctctcgtcc ccctgaggct      180

gtggctgctg gtcacgagga actgcccctg tgcttcgctc tgaagtccca cttcgtgggt      240

gctgtgatcg gtcgcggtgg ttccaagatc aagaacatcc agtccaccac caacaccacc      300

atccagatca tccaagagca gcccgagtcc ctggtcaaga tcttcggttc caaggctatg      360

cagaccaagg ctaaggctgt gatcgacaac ttcgtgaaga agctggaaga gaactacaac      420

tccgagtgcg gtatcgacac cgctttccag ccctccgtgg gcaaggacgg ttccaccgac      480

aacaacgtgg tggctggcga ccgtcccctg atcgactggg accagatccg tgaagagggc      540

ctgaagtggc aaaagaccaa gtgggctgac ctgcccccca tcaagaagaa cttctacaag      600

gaatccaccg ctacctccgc tatgtccaag gtcgaggctg actcctggcg caaggaaaac      660

ttcaacatca cctgggacga cctgaaggac ggcgagaagc gtcccatccc caaccctacc      720

tgcaccttcg acgacgcttt ccagtgctac cccgaagtga tggaaaacat caagaaggct      780

ggtttccaga agcccacccc catccagtcc caggcttggc ccatcgtgct gcagggtatc      840

gacctgatcg gtgtcgctca gaccggcacc ggcaagaccc tgtgctacct gatgcccggt      900

ttcatccacc tggtgctgca gccctccctg aagggccagc gtaaccgtcc cggcatgctg      960

gtgctgaccc ctacccgcga actggctctg caggtcgagg gcgagtgctg caagtactcc     1020

tacaagggcc tgcgttccgt gtgcgtgtac ggtggtggca accgtgacga gcagatcgag     1080

gaactcaaga agggtgtcga catcatcatc gctacccccg gtcgtctgaa cgacctgcag     1140

atgtccaact tcgtcaacct gaagaacatc acctacctgg tcctggacga ggctgacaag     1200

atgctggaca tgggtttcga gccccagatc atgaagatcc tgctggacgt gcgtcccgac     1260

cgtcagaccg tgatgacctc cgctacctgg ccccactccg tgcaccgtct ggctcagtcc     1320

tacctgaagg aacccatgat cgtgtacgtg ggcaccctgg acctggtggc tgtgtcctcc     1380

gtgaagcaga acatcatcgt gaccaccgag gaagagaagt ggtcccacat gcagactttc     1440

ttgcagtcca tgtcctctac cgacaaggtc atcgtgttcg tgtcccgcaa ggctgtcgct     1500

gaccacctgt cctccgacct gatcctgggc aacatctccg tcgagtccct gcacggcgac     1560

cgcgagcagc gtgaccgcga gaaggctctc gagaacttca agaccggcaa ggtccgcatc     1620

ctgatcgcta ccgacctggc ttcccgcgga ctggacgtgc acgacgtgac ccacgtgtac     1680

aacttcgact tcccccgtaa catcgaggaa tacgtgcacc gtatcggtcg taccggtcgt     1740

gctggtcgca ccggtgtctc catcaccacc ctgacccgta acgactggcg tgtggcttcc     1800

gagctgatca acatcctcga gcgtgctaac cagtccatcc ccgaggaact ggtgtctatg     1860

gctgagcgtt tcaaggctca ccagcaaaag cgcgagatgg aacgcaagat ggaacgtccc     1920

cagggtcgtc ccaagaagtt ccac                                            1944


<210>  6
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  6
atgtcctggc gtggtcgttc cacctactac tggccccgtc cccgtcgtta cgtgcagccc       60

cccgagatga tcggtcccat gcgtcccgag cagttctccg acgaggtcga gcccgctacc      120

cccgaggaag gcgagcctgc tactcagcgt caggaccccg ctgctgctca agagggcgag      180

gacgagggcg cttccgctgg ccagggtcct aagcccgagg ctgactccca agagcagggt      240

cacccccaga ccggttgcga gtgcgaggac ggtcccgacg gtcaagagat ggaccccccc      300

aaccctgagg aagtcaagac ccccgaagag ggcgaaggcc agtcccagtg c               351


<210>  7
<211>  1107
<212>  DNA
<213>  Homo sapiens

<400>  7
atgccccgtg ctcccaagcg tcagcgttgc atgcccgaag aggacctgca gtcccagtcc       60

gagactcagg gcctcgaggg tgctcaggct cccctggctg tggaagagga cgcttccagc      120

tctacctcta cctcctccag cttccccagc agcttcccat cctccagctc ctctagctcc      180

tcctcctgct accccctgat cccctccacc cccgaggaag tgtccgctga cgacgagact      240

cccaaccccc cccagtccgc tcagatcgct tgctcctccc cctccgtggt ggcttccctg      300

cctctggacc agtccgacga gggttccagc tcccagaagg aagagtcccc cagcaccctg      360

caggtcctgc ccgactccga gtccctgccc cgttccgaga tcgacgagaa ggttacagac      420

ctggtgcagt tcctgctgtt caagtaccag atgaaggaac ccatcaccaa ggctgagatc      480

ctcgagtccg tgatcaagaa ctacgaggac cacttccccc tgctgttctc cgaggcttcc      540

gagtgcatgc tgctggtgtt cggtatcgac gtgaaggaag tggaccctac cggtcactcc      600

ttcgtgctgg tcacctccct gggcctgacc tacgacggca tgctgtccga cgtgcagtcc      660

atgcccaaga ccggtatcct gatcctcatc ctgtccatca tcttcatcga gggctactgc      720

actcctgagg aagtgatctg ggaggctctg aacatgatgg gcctgtacga cggaatggaa      780

cacctgatct acggcgagcc ccgcaagctg ctgacccagg actgggtgca agagaactac      840

ctcgagtacc gtcaggtgcc cggttccgac cccgctcgtt acgagttcct gtggggtccc      900

cgtgctcacg ctgagatccg caagatgtcc ctgctgaagt tcctggctaa ggtcaacggc      960

tccgaccccc gttccttccc actgtggtac gaggaagctc tgaaggacga ggaagagagg     1020

gctcaggacc gtatcgctac caccgacgac accaccgcta tggcttccgc ttcctctagc     1080

gctaccggtt ccttcagcta ccccgag                                         1107


<210>  8
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  8
atgtctgtca tggacctcgc caatacttgc tccagctttc agtcggacct ggatttctgt       60

tcagattgcg gctcggtcct gcctctgccc ggggctcagg atacggtcac ctgtattcgc      120

tgtggcttca acatcaacgt tcgggacttt gaggggaagg ttgtgaagac ttcggttgtg      180

ttccaccaac tggggacagc catgcctatg tcggtggagg aagggcctga gtgccaggga      240

cctgtggttg acaggcgctg ccctcgatgt ggtcatgaag gaatggcata ccacaccaga      300

cagatgcgtt cagccgatga agggcaaact gtcttctaca cctgtaccaa ctgcaagttc      360

caggagaagg aagactct                                                    378


<210>  9
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  9
atgctgtggc tagcccttgg cccctttcct gccatggaga accaggtgct ggtaattcgc       60

atcaagatcc caaatagtgg cgcggtggac tggacagtgc actccgggcc gcagttactc      120

ttcagggatg tgctggatgt gataggccag gttctgcctg aagcaacaac tacagcattt      180

gaatatgaag atgaagatgg tgatcgaatt acagtgagaa gtgatgagga aatgaaggca      240

atgctgtcat attattattc cacagtaatg gaacagcaag taaatggaca gttaatagag      300

cctctgcaga tatttccaag agcctgcaag cctcctgggg aacggaacat acatggcctg      360

aaggtgaata ctcgggccgg accctctcaa cacagcagcc cagcagtctc agattcactt      420

ccaagcaata gcttaaagaa gtcttctgct gaactgaaaa aaatactagc caatggccag      480

atgaatgaac aagacatacg atatcgggac actcttggtc atggcaacgg aggcacagtc      540

tacaaagcat atcatgtccc gagtgggaaa atattagctg taaaggtcat actactagat      600

attacactgg aacttcagaa gcaaattatg tctgaattgg aaattcttta taagtgcgat      660

tcatcatata tcattggatt ttatggagca ttttttgtag aaaacaggat ttcaatatgt      720

acagaattca tggatggggg atctttggat gtatatagga aaatgccaga acatgtcctt      780

ggaagaattg cagtagcagt tgttaaaggc cttacttatt tgtggagttt aaagatttta      840

catagagacg tgaagccctc caatatgcta gtaaacacaa gaggacaggt taagctgtgt      900

gattttggag ttagcactca gctggtgaat tctatagcca agacgtatgt tggaacaaat      960

gcttatatgg cgcctgaaag gatttcaggg gagcagtatg gaattcattc tgatgtctgg     1020

agcttaggaa tctcttttat ggagcttgct cttgggaggt ttccatatcc tcagattcag     1080

aaaaaccagg gatctttaat gcctctccag cttctgcagt gcattgttga tgaggattcg     1140

cccgtccttc cagttggaga gttctcggag ccatttgtac atttcatcac tcagtgtatg     1200

cgaaaacagc caaaagaaag gccagcacct gaagaattga tgggccaccc gttcatcgtg     1260

cagttcaatg atggaaatgc cgccgtggtg tccatgtggg tgtgccgggc gctggaggag     1320

aggcggagcc agcaggggcc cccg                                            1344


<210>  10
<211>  951
<212>  DNA
<213>  Homo sapiens

<400>  10
atgtcttctg agcagaagag tcagcactgc aagcctgagg aaggcgttga ggcccaagaa       60

gaggccctgg gcctggtggg tgcacaggct cctactactg aggagcagga ggctgctgtc      120

tcctcctcct ctcctctggt ccctggcacc ctggaggaag tgcctgctgc tgagtcagca      180

ggtcctcccc agagtcctca gggagcctct gccttaccca ctaccatcag cttcacttgc      240

tggaggcaac ccaatgaggg ttccagcagc caagaagagg aggggccaag cacctcgcct      300

gacgcagagt ccttgttccg agaagcactc agtaacaagg tggatgagtt ggctcatttt      360

ctgctccgca agtatcgagc caaggagctg gtcacaaagg cagaaatgct ggagagagtc      420

atcaaaaatt acaagcgctg ctttcctgtg atcttcggca aagcctccga gtccctgaag      480

atgatctttg gcattgacgt gaaggaagtg gaccccacca gcaacaccta cacccttgtc      540

acctgcctgg gcctttccta tgatggcctg ctgggtaata atcagatctt tcccaagaca      600

ggccttctga taatcgtcct gggcacaatt gcaatggagg gcgacagcgc ctctgaggag      660

gaaatctggg aggagctggg tgtgatgggg gtgtatgatg ggagggagca cactgtctat      720

ggggagccca ggaaactgct cacccaagat tgggtgcagg aaaactacct ggagtaccgg      780

caggtacccg gcagtaatcc tgcgcgctat gagttcctgt ggggtccaag ggctctggct      840

gaaaccagct atgtgaaagt cctggagcat gtggtcaggg tcaatgcaag agttcgcatt      900

gcctacccat ccctgcgtga agcagctttg ttagaggagg aagagggagt c               951


<210>  11
<211>  2136
<212>  DNA
<213>  Homo sapiens

<400>  11
atgtctcagt ggtacgaact tcagcagctt gactcaaaat tcctggagca ggttcaccag       60

ctttatgatg acagttttcc catggaaatc agacagtacc tggcacagtg gttagaaaag      120

caagactggg agcacgctgc caatgatgtt tcatttgcca ccatccgttt tcatgacctc      180

ctgtcacagc tggatgatca atatagtcgc ttttctttgg agaataactt cttgctacag      240

cataacataa ggaaaagcaa gcgtaatctt caggataatt ttcaggaaga cccaatccag      300

atgtctatga tcatttacag ctgtctgaag gaagaaagga aaattctgga aaacgcccag      360

agatttaatc aggctcagtc ggggaatatt cagagcacag tgatgttaga caaacagaaa      420

gagcttgaca gtaaagtcag aaatgtgaag gacaaggtta tgtgtataga gcatgaaatc      480

aagagcctgg aagatttaca agatgaatat gacttcaaat gcaaaacctt gcagaacaga      540

gaacacgaga ccaatggtgt ggcaaagagt gatcagaaac aagaacagct gttactcaag      600

aagatgtatt taatgcttga caataagaga aaggaagtag ttcacaaaat aatagagttg      660

ctgaatgtca ctgaacttac ccagaatgcc ctgattaatg atgaactagt ggagtggaag      720

cggagacagc agagcgcctg tattgggggg ccgcccaatg cttgcttgga tcagctgcag      780

aactggttca ctatagttgc ggagagtctg cagcaagttc ggcagcagct taaaaagttg      840

gaggaattgg aacagaaata cacctacgaa catgacccta tcacaaaaaa caaacaagtg      900

ttatgggacc gcaccttcag tcttttccag cagctcattc agagctcgtt tgtggtggaa      960

agacagccct gcatgccaac gcaccctcag aggccgctgg tcttgaagac aggggtccag     1020

ttcactgtga agttgagact gttggtgaaa ttgcaagagc tgaattataa tttgaaagtc     1080

aaagtcttat ttgataaaga tgtgaatgag agaaatacag taaaaggatt taggaagttc     1140

aacattttgg gcacgcacac aaaagtgatg aacatggagg agtccaccaa tggcagtctg     1200

gcggctgaat ttcggcacct gcaattgaaa gaacagaaaa atgctggcac cagaacgaat     1260

gagggtcctc tcatcgttac tgaagagctt cactccctta gttttgaaac ccaattgtgc     1320

cagcctggtt tggtaattga cctcgagacg acctctctgc ccgttgtggt gatctccaac     1380

gtcagccagc tcccgagcgg ttgggcctcc atcctttggt acaacatgct ggtggcggaa     1440

cccaggaatc tgtccttctt cctgactcca ccatgtgcac gatgggctca gctttcagaa     1500

gtgctgagtt ggcagttttc ttctgtcacc aaaagaggtc tcaatgtgga ccagctgaac     1560

atgttgggag agaagcttct tggtcctaac gccagccccg atggtctcat tccgtggacg     1620

aggttttgta aggaaaatat aaatgataaa aattttccct tctggctttg gattgaaagc     1680

atcctagaac tcattaaaaa acacctgctc cctctctgga atgatgggtg catcatgggc     1740

ttcatcagca aggagcgaga gcgtgccctg ttgaaggacc agcagccggg gaccttcctg     1800

ctgcggttca gtgagagctc ccgggaaggg gccatcacat tcacatgggt ggagcggtcc     1860

cagaacggag gcgaacctga cttccatgcg gttgaaccct acacgaagaa agaactttct     1920

gctgttactt tccctgacat cattcgcaat tacaaagtca tggctgctga gaatattcct     1980

gagaatcccc tgaagtatct gtatccaaat attgacaaag accatgcctt tggaaagtat     2040

tactccaggc caaaggaagc accagagcca atggaacttg atggccctaa aggaactgga     2100

tatatcaaga ctgagttgat ttctgtgtct gaagtg                               2136


<210>  12
<211>  864
<212>  DNA
<213>  Homo sapiens

<400>  12
atgtccgcta ccggcgaccg tcaccctacc cagggcgacc aagaggctcc cgtgtcccaa       60

gagggtgctc aggctgaggc tgctggtgct ggcaaccagg aaggtggcga ctccggtccc      120

gactcctccg acgtggtgcc tgctgctgag gtcgtgggtg tcgctggtcc tgtcgagggc      180

ctgggagagg aagagggcga gcaggctgct ggcctggctg ctgtgcctcg tggtggttcc      240

gctgaagagg actccgacat cggtcccgct accgaggaag aggaagaaga agagggcaac      300

gaggctgcta acttcgacct ggctgtggtg gctcgtcgtt accccgcttc cggtatccac      360

ttcgtgctgc tggacatggt gcactccctg ctgcaccgtc tgtcccacaa cgaccacatc      420

ctgatcgaga accgtcagct gtcccgtctg atggtcggac cccacgctgc tgctcgtaac      480

ctgtggggca acctgccccc cctgctgctg cctcaacgtc tgggagctgg tgctgctgct      540

agggctggcg agggactggg cctgatccaa gaggctgctt ccgtgcccga gcccgctgtg      600

cctgctgact tggctgagat ggcccgcgag cctgctgagg aagctgctga agagaagctg      660

tccgaggaag ccaccgagga acccgacgct gaggaaccag ctactgagga acccaccgct      720

caagaggcta ccgctcctga ggaagtgacc aagtcccagc ccgagaagtg ggacgaggaa      780

gctcaggacg ctgctggcga ggaagagaag gaacaagaaa aggaaaagga cgccgagaac      840

aaggtcaaga actccaaggg cacc                                             864


<210>  13
<211>  1737
<212>  DNA
<213>  Homo sapiens

<400>  13
atgaacaagc tgtacatcgg caacctgtcc gagaacgctg ctccctccga cctcgagtcc       60

atcttcaagg acgctaagat ccccgtgtcc ggacccttcc tggtcaagac cggttacgct      120

ttcgtggact gccccgacga gtcctgggct ctgaaggcta tcgaggctct gtccggcaag      180

atcgagctgc acggcaagcc catcgaggtc gagcactccg tgcccaagcg tcagcgtatc      240

cgcaagctgc agatccgtaa catcccccca cacctccagt gggaggtgct ggactccctg      300

ctggtgcagt acggtgtcgt cgagtcctgc gagcaagtga acaccgactc cgagactgct      360

gtggtcaacg tgacctactc ctccaaggac caggctcgtc aggctctgga caagctgaac      420

ggtttccagc tcgagaactt caccctgaag gtggcctaca tccccgacga gatggctgct      480

cagcagaacc ccctgcagca gccccgtggt cgtcgtggac tgggacagcg tggtagctcc      540

cgtcagggtt cccccggttc cgtgtccaag cagaagccct gcgacctgcc cctgcgtctg      600

ctggtgccta cccagttcgt gggtgctatc atcggcaagg aaggtgctac catccgcaac      660

atcaccaagc agacccagtc caagatcgac gtccaccgca aggaaaacgc tggcgctgct      720

gagaagtcca tcaccatcct gtccaccccc gagggcacct ccgctgcttg caagtccatc      780

ctcgagatca tgcacaagga agcccaggac atcaagttca ccgaggaaat ccccctgaag      840

atcctggctc acaacaactt cgtgggtcgt ctgatcggaa aggaaggccg taacctgaag      900

aagatcgagc aggacaccga caccaagatc accatctccc cactgcaaga gctgaccctg      960

tacaaccccg agcgtaccat caccgtgaag ggcaacgtgg aaacctgcgc taaggctgaa     1020

gaggaaatca tgaagaagat ccgcgagtcc tacgagaacg atatcgcttc catgaacctg     1080

caggctcacc tgatccccgg cctgaacctg aacgctctgg gcctgttccc ccctacctcc     1140

ggcatgcctc ctcccacctc tggtcccccc tccgctatga cccccccata cccccagttc     1200

gagcagtccg agactgagac tgtgcacctg ttcatccccg ctctgtccgt cggtgccatc     1260

atcggaaagc agggccagca catcaagcag ctgtcccgtt tcgctggtgc ttccatcaag     1320

atcgctcccg ctgaggctcc cgacgctaag gtccgcatgg tcatcatcac cggtcccccc     1380

gaggctcagt tcaaggctca gggtcgtatc tacggcaaga tcaaggaaga gaacttcgtc     1440

agccccaagg aagaagtgaa gctcgaggct cacatccgtg tgccatcctt cgctgctggt     1500

cgtgttatcg gcaagggtgg caagaccgtg aacgagctgc agaacctgtc ctccgctgag     1560

gtggtggtgc cccgtgacca gacccctgac gagaacgacc aggtggtggt caagatcacc     1620

ggtcacttct acgcttgcca ggtggcccag cgcaagatcc aagagatcct gacccaagtg     1680

aagcagcacc agcagcagaa ggctctgcag tccggtcccc ctcagtcccg tcgcaag        1737


<210>  14
<211>  630
<212>  DNA
<213>  Homo sapiens

<400>  14
atgcaggccg aaggccgggg cacagggggt tcgacgggcg atgctgatgg cccaggaggc       60

cctggcattc ctgatggccc agggggcaat gctggcggcc caggagaggc gggtgccacg      120

ggcggcagag gtccccgggg cgcaggggca gcaagggcct cggggccgag aggaggcgcc      180

ccgcggggtc cgcatggcgg tgccgcttct gcgcaggatg gaaggtgccc ctgcggggcc      240

aggaggccgg acagccgcct gcttgagttg cacatcacga tgcctttctc gtcgcccatg      300

gaagcggagc tggtccgcag gatcctgtcc cgggatgccg caccgctccc ccgaccaggg      360

gcggttctga aggacttcac cgtgtccggc aacctactgt ttatgtcagt tcgggaccag      420

gacagggaag gcgctgggcg gatgagggtg gtgggttggg ggctgggatc cgcctccccg      480

gaggggcaga aagctagaga tctcagaaca cccaaacaca aggtctcaga acagagacct      540

ggtacaccag gcccgccgcc acccgaggga gcccagggag atgggtgcag aggtgtcgcc      600

tttaatgtga tgttctctgc ccctcacatt                                       630


<210>  15
<211>  1227
<212>  DNA
<213>  Homo sapiens

<400>  15
atgcaggtca ccctgaagac cctccagcag cagaccttca agatagacat tgaccccgag       60

gagacggtga aagcactgaa agagaagatt gaatctgaaa aggggaaaga tgcctttcca      120

gtagcaggtc aaaaattaat ttatgcaggc aaaatcctca atgatgatac tgctctcaaa      180

gaatataaaa ttgatgagaa aaactttgtg gtggttatgg tgaccaaacc caaagcagtg      240

tccacaccag caccagctac aactcagcag tcagctcctg ccagcactac agcagttact      300

tcctccacca ccacaactgt ggctcaggct ccaacccctg tccctgcctt ggcccccact      360

tccacacctg catccatcac tccagcatca gcgacagcat cttctgaacc tgcacctgct      420

agtgcagcta aacaagagaa gcctgcagaa aagccagcag agacaccagt ggctactagc      480

ccaacagcaa ctgacagtac atcgggtgat tcttctcggt caaacctttt tgaagatgca      540

acgagtgcac ttgtgacggg tcagtcttac gagaatatgg taactgagat catgtcaatg      600

ggctatgaac gagagcaagt aattgcagcc ctgagagcca gtttcaacaa ccctgacaga      660

gcagtggagt atcttttaat gggaatccct ggagatagag aaagtcaggc tgtggttgac      720

ccccctcaag cagctagtac tggggttcct cagtcttcag cagtggctgc agctgcagca      780

actacgacag caacaactac aacaacaagt tctggaggac atccccttga atttttacgg      840

aatcagcctc agtttcaaca gatgagacaa attattcagc agaatccttc cttgcttcca      900

gcgttactac agcagatagg tcgagagaat cctcaattac ttcagcaaat tagccaacac      960

caggagcatt ttattcagat gttaaatgaa ccagttcaag aagctggtgg tcaaggagga     1020

ggaggtggag gtggcagtgg aggaattgca gaagctggaa gtggtcatat gaactacatt     1080

caagtaacac ctcaggaaaa agaagctata gaaaggttaa aggcattagg atttcctgaa     1140

ggacttgtga tacaagcgta ttttgcttgt gagaagaatg agaatttggc tgccaatttt     1200

cttctacagc agaactttga tgaagat                                         1227


<210>  16
<211>  624
<212>  DNA
<213>  Homo sapiens

<400>  16
atggacccgt tcctggtgct gctgcactcg gtgtcgtcca gcctgtcgag cagcgagctg       60

accgagctca agttcctatg cctcgggcgc gtgggcaagc gcaagctgga gcgcgtgcag      120

agcggcctag acctcttctc catgctgctg gagcagaacg acctggagcc cgggcacacc      180

gagctcctgc gcgagctgct cgcctccctg cggcgccacg acctgctgcg gcgcgtcgac      240

gacttcgagg cgggggcggc ggccggggcc gcgcctgggg aagaagacct gtgtgcagca      300

tttaacgtca tatgtgataa tgtggggaaa gattggagaa ggctggctcg tcagctcaaa      360

gtctcagaca ccaagatcga cagcatcgag gacagatacc cccgcaacct gacagagcgt      420

gtgcgggagt cactgagaat ctggaagaac acagagaagg agaacgcaac agtggcccac      480

ctggtggggg ctctcaggtc ctgccagatg aacctggtgg ctgacctggt acaagaggtt      540

cagcaggccc gtgacctcca gaacaggagt ggggccatgt ccccgatgtc atggaactca      600

gacgcatcta cctccgaagc gtcc                                             624


<210>  17
<211>  678
<212>  DNA
<213>  Homo sapiens

<400>  17
atgtcctccc cccgtgactt ccgtgctgag cccgtgaacg actacgaggg caacgactcc       60

gaggctgagg acctgaactt ccgtgaaacc ctgccctcca gctcccaaga gaacaccccc      120

cgttccaagg tgttcgagaa caaggtcaac tccgagaagg tcaagctgtc cctgcgcaac      180

ttcccccaca acgattacga ggacgtgttc gaggaaccct ccgagtccgg ttccgacccc      240

tccatgtgga ccgctcgtgg tcccttccgt cgtgaccgtt ggtcctccga ggacgaggaa      300

gctgctggac cctcccaggc tctgtccccc ctgctgtccg acacccgcaa gatcgtgtcc      360

gagggcgagc tggaccagct ggctcagatc cgtcccctga tcttcaactt ccacgagcag      420

accgctatca aggactgcct gaagatcctc gaggaaaaga ccgctgctta cgacatcatg      480

caagagttca tggctctcga gctgaagaac ctgcccggcg agttcaactc cggcaaccag      540

ccctccaacc gcgagaagaa ccgttaccgt gacatcctgc ctttccagca ccacggttac      600

tccggtccca acgagcgtac caccttctgg cacggttcca acgagggtgc tgtgtccctg      660

ctgctgcgct actgcgct                                                    678


<210>  18
<211>  852
<212>  DNA
<213>  Homo sapiens

<400>  18
atggacgcca tcaagaagaa gatgcagatg ctgaagctcg acaaggagaa cgccttggat       60

cgagctgagc aggcggaggc cgacaagaag gcggcggaag acaggagcaa gcagctggaa      120

gatgagctgg tgtcactgca aaagaaactc aagggcaccg aagatgaact ggacaaatat      180

tctgaggctc tcaaagatgc ccaggagaag ctggagctgg cagagaaaaa ggccaccgat      240

gctgaagccg acgtagcttc tctgaacaga cgcatccagc tggttgagga agagttggat      300

cgtgcccagg agcgtctggc aacagctttg cagaagctgg aggaagctga gaaggcagca      360

gatgagagtg agagaggcat gaaagtcatt gagagtcgag cccaaaaaga tgaagaaaaa      420

atggaaattc aggagatcca actgaaagag gcaaagcaca ttgctgaaga tgccgaccgc      480

aaatatgaag aggtggcccg taagctggtc atcattgaga gcgacctgga acgtgcagag      540

gagcgggctg agctctcaga aggccaagtc cgacagctgg aagaacaatt aagaataatg      600

gatcagacct tgaaagcatt aatggctgca gaggataagt actcgcagaa ggaagacaga      660

tatgaggaag agatcaaggt cctttccgac aagctgaagg aggctgagac tcgggctgag      720

tttgcggaga ggtcagtaac taaattggag aaaagcattg atgacttaga agacgagctg      780

tacgctcaga aactgaagta caaagccatc agcgaggagc tggaccacgc tctcaacgat      840

atgacttcca tg                                                          852


<210>  19
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  19
atgcaggctg agggtcgtgg caccggtggt tccactggcg acgctgacgg tcccggtggt       60

cctggtatcc ccgacggtcc tggtggcaac gctggtggtc caggcgaggc tggtgctacc      120

ggtggtcgtg gtcctcgtgg tgctggtgct gctcgtgctt ccggtccagg tggtggtgct      180

ccccgtggtc ctcacggtgg tgctgcttcc ggcctgaacg gttgctgccg ttgcggtgct      240

cgcggtcccg agtcccgtct gctcgagttc tacctggcta tgcccttcgc tacccctatg      300

gaagctgagc tggctcgtcg ttccctggct caggacgctc ctcctctgcc cgtgcccggt      360

gtcctgctga aggagttcac tgtctccggc aacatcctga ccatccgtct gaccgctgct      420

gaccaccgtc agctccagct gtccatctcc tcatgcctgc agcagctgtc cctgctgatg      480

tggatcaccc agtgtttctt gcccgtgttc ctggctcagc ccccctccgg tcaacgtcgt      540


<210>  20
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Ser Pro Lys Lys Lys Asn Gln Gln Leu Lys Val Gly Ile Leu 
1               5                   10                  15      


His Leu Gly Ser Arg Gln Lys Lys Ile Arg Ile Gln Leu Arg Ser Gln 
            20                  25                  30          


Cys Ala Thr Trp Lys Val Ile Cys Lys Ser Cys Ile Ser Gln Thr Pro 
        35                  40                  45              


Gly Ile Asn Leu Asp Leu Gly Ser Gly Val Lys Val Lys Ile Ile Pro 
    50                  55                  60                  


Lys Glu Glu His Cys Lys Met Pro Glu Ala Gly Glu Glu Gln Pro Gln 
65                  70                  75                  80  


Val 
    


<210>  21
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Thr Pro Ala Ser Gly Arg Lys Arg Thr Pro Val Lys Asp Arg 
1               5                   10                  15      


Phe Ser Ala Glu Asp Glu Ala Leu Ser Asn Ile Ala Arg Glu Ala Glu 
            20                  25                  30          


Ala Arg Leu Ala Ala Lys Arg Ala Ala Arg Ala Glu Ala Arg Asp Ile 
        35                  40                  45              


Arg Met Arg Glu Leu Glu Arg Gln Gln Lys Glu Leu Asp Glu Lys Ser 
    50                  55                  60                  


Asp Lys Gln Tyr Ala Glu Asn Tyr Thr Arg Pro Ser Ser Arg Asn Ser 
65                  70                  75                  80  


Ala Ser Ala Thr Thr Pro Leu Ser Gly Asn Ser Ser Arg Arg Gly Ser 
                85                  90                  95      


Gly Asp Thr Ser Ser Leu Ile Asp Pro Asp Thr Ser Leu Ser Glu Leu 
            100                 105                 110         


Arg Glu Ser Leu Ser Glu Val Glu Glu Lys Tyr Lys Lys Ala Met Val 
        115                 120                 125             


Ser Asn Ala Gln Leu Asp Asn Glu Lys Asn Asn Leu Ile Tyr Gln Val 
    130                 135                 140                 


Asp Thr Leu Lys Asp Val Ile Glu Glu Gln Glu Glu Gln Met Ala Glu 
145                 150                 155                 160 


Phe Tyr Arg Glu Asn Glu Glu Lys Ser Lys Glu Leu Glu Arg Gln Lys 
                165                 170                 175     


His Met Cys Ser Val Leu Gln His Lys Met Glu Glu Leu Lys Glu Gly 
            180                 185                 190         


Leu Arg Gln Arg Asp Glu Leu Ile Glu Lys His Gly Leu Val Ile Ile 
        195                 200                 205             


Pro Asp Gly Thr Pro Asn Gly Asp Val Ser His Glu Pro Val Ala Gly 
    210                 215                 220                 


Ala Ile Thr Val Val Ser Gln Glu Ala Ala Gln Val Leu Glu Ser Ala 
225                 230                 235                 240 


Gly Glu Gly Pro Leu Asp Val Arg Leu Arg Lys Leu Ala Gly Glu Lys 
                245                 250                 255     


Glu Glu Leu Leu Ser Gln Ile Arg Lys Leu Lys Leu Gln Leu Glu Glu 
            260                 265                 270         


Glu Arg Gln Lys Cys Ser Arg Asn Asp Gly Thr Val Gly Asp Leu Ala 
        275                 280                 285             


Gly Leu Gln Asn Gly Ser Asp Leu Gln Phe Ile Glu Met Gln Arg Asp 
    290                 295                 300                 


Ala Asn Arg Gln Ile Ser Glu Tyr Lys Phe Lys Leu Ser Lys Ala Glu 
305                 310                 315                 320 


Gln Asp Ile Thr Thr Leu Glu Gln Ser Ile Ser Arg Leu Glu Gly Gln 
                325                 330                 335     


Val Leu Arg Tyr Lys Thr Ala Ala Glu Asn Ala Glu Lys Val Glu Asp 
            340                 345                 350         


Glu Leu Lys Ala Glu Lys Arg Lys Leu Gln Arg Glu Leu Arg Thr Ala 
        355                 360                 365             


Leu Asp Lys Ile Glu Glu Met Glu Met Thr Asn Ser His Leu Ala Lys 
    370                 375                 380                 


Arg Leu Glu Lys Met Lys Ala Asn Arg Thr Ala Leu Leu Ala Gln Gln 
385                 390                 395                 400 


<210>  22
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Trp Arg Gly Arg Ser Thr Tyr Arg Pro Arg Pro Arg Arg Tyr 
1               5                   10                  15      


Val Glu Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe Ser 
            20                  25                  30          


Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr Gln 
        35                  40                  45              


Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala Ser 
    50                  55                  60                  


Ala Gly Gln Gly Pro Lys Pro Glu Ala His Ser Gln Glu Gln Gly His 
65                  70                  75                  80  


Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu Met 
                85                  90                  95      


Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Gly Glu Lys 
            100                 105                 110         


Gln Ser Gln Cys 
        115     


<210>  23
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ser His Trp Ala Pro Glu Trp Lys Arg Ala Glu Ala Asn Pro Arg 
1               5                   10                  15      


Asp Leu Gly Ala Ser Trp Asp Val Arg Gly Ser Arg Gly Ser Gly Trp 
            20                  25                  30          


Ser Gly Pro Phe Gly His Gln Gly Pro Arg Ala Ala Gly Ser Arg Glu 
        35                  40                  45              


Pro Pro Leu Cys Phe Lys Ile Lys Asn Asn Met Val Gly Val Val Ile 
    50                  55                  60                  


Gly Tyr Ser Gly Ser Lys Ile Lys Asp Leu Gln His Ser Thr Asn Thr 
65                  70                  75                  80  


Lys Ile Gln Ile Ile Asn Gly Glu Ser Glu Ala Lys Val Arg Ile Phe 
                85                  90                  95      


Gly Asn Arg Glu Met Lys Ala Lys Ala Lys Ala Ala Ile Glu Thr Leu 
            100                 105                 110         


Ile Arg Lys Gln Glu Ser Tyr Asn Ser Glu Ser Ser Val Asp Asn Ala 
        115                 120                 125             


Ala Ser Gln Thr Pro Ile Gly Arg Asn Leu Gly Arg Asn Asp Ile Val 
    130                 135                 140                 


Gly Glu Ala Glu Pro Leu Ser Asn Trp Asp Arg Ile Arg Ala Ala Val 
145                 150                 155                 160 


Val Glu Cys Glu Lys Arg Lys Trp Ala Asp Leu Pro Pro Val Lys Lys 
                165                 170                 175     


Asn Phe Tyr Ile Glu Ser Lys Ala Thr Ser Cys Met Ser Glu Met Gln 
            180                 185                 190         


Val Ile Asn Trp Arg Lys Glu Asn Phe Asn Ile Thr Cys Asp Asp Leu 
        195                 200                 205             


Lys Ser Gly Glu Lys Arg Leu Ile Pro Lys Pro Thr Cys Arg Phe Lys 
    210                 215                 220                 


Asp Ala Phe Gln Gln Tyr Pro Asp Leu Leu Lys Ser Ile Ile Arg Val 
225                 230                 235                 240 


Gly Ile Val Lys Pro Thr Pro Ile Gln Ser Gln Ala Trp Pro Ile Ile 
                245                 250                 255     


Leu Gln Gly Ile Asp Leu Ile Val Val Ala Gln Thr Gly Thr Gly Lys 
            260                 265                 270         


Thr Leu Ser Tyr Leu Met Pro Gly Phe Ile His Leu Asp Ser Gln Pro 
        275                 280                 285             


Ile Ser Arg Glu Gln Arg Asn Gly Pro Gly Met Leu Val Leu Thr Pro 
    290                 295                 300                 


Thr Arg Glu Leu Ala Leu His Val Glu Ala Glu Cys Ser Lys Tyr Ser 
305                 310                 315                 320 


Tyr Lys Gly Leu Lys Ser Ile Cys Ile Tyr Gly Gly Arg Asn Arg Asn 
                325                 330                 335     


Gly Gln Ile Glu Asp Ile Ser Lys Gly Val Asp Ile Ile Ile Ala Thr 
            340                 345                 350         


Pro Gly Arg Leu Asn Asp Leu Gln Met Asn Asn Ser Val Asn Leu Arg 
        355                 360                 365             


Ser Ile Thr Tyr Leu Val Ile Asp Glu Ala Asp Lys Met Leu Asp Met 
    370                 375                 380                 


Glu Phe Glu Pro Gln Ile Arg Lys Ile Leu Leu Asp Val Arg Pro Asp 
385                 390                 395                 400 


Arg Gln Thr Val Met Thr Ser Ala Thr Trp Pro Asp Thr Val Arg Gln 
                405                 410                 415     


Leu Ala Leu Ser Tyr Leu Lys Asp Pro Met Ile Val Tyr Val Gly Asn 
            420                 425                 430         


Leu Asn Leu Val Ala Val Asn Thr Val Lys Gln Asn Ile Ile Val Thr 
        435                 440                 445             


Thr Glu Lys Glu Lys Arg Ala Leu Thr Gln Glu Phe Val Glu Asn Met 
    450                 455                 460                 


Ser Pro Asn Asp Lys Val Ile Met Phe Val Ser Gln Lys His Ile Ala 
465                 470                 475                 480 


Asp Asp Leu Ser Ser Asp Phe Asn Ile Gln Gly Ile Ser Ala Glu Ser 
                485                 490                 495     


Leu His Gly Asn Ser Glu Gln Ser Asp Gln Glu Arg Ala Val Glu Asp 
            500                 505                 510         


Phe Lys Ser Gly Asn Ile Lys Ile Leu Ile Thr Thr Asp Ile Val Ser 
        515                 520                 525             


Arg Gly Leu Asp Leu Asn Asp Val Thr His Val Tyr Asn Tyr Asp Phe 
    530                 535                 540                 


Pro Arg Asn Ile Asp Val Tyr Val His Arg Val Gly Tyr Ile Gly Arg 
545                 550                 555                 560 


Thr Gly Lys Thr Gly Thr Ser Val Thr Leu Ile Thr Gln Arg Asp Ser 
                565                 570                 575     


Lys Met Ala Gly Glu Leu Ile Lys Ile Leu Asp Arg Ala Asn Gln Ser 
            580                 585                 590         


Val Pro Glu Asp Leu Val Val Met Ala Glu Gln Tyr Lys Leu Asn Gln 
        595                 600                 605             


Gln Lys Arg His Arg Glu Thr Arg Ser Arg Lys Pro Gly Gln Arg Arg 
    610                 615                 620                 


Lys Glu Phe Tyr Phe Leu Ser 
625                 630     


<210>  24
<211>  648
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser His His Gly Gly Ala Pro Lys Ala Ser Thr Trp Val Val Ala 
1               5                   10                  15      


Ser Arg Arg Ser Ser Thr Val Ser Arg Ala Pro Glu Arg Arg Pro Ala 
            20                  25                  30          


Glu Glu Leu Asn Arg Thr Gly Pro Glu Gly Tyr Ser Val Gly Arg Gly 
        35                  40                  45              


Gly Arg Trp Arg Gly Thr Ser Arg Pro Pro Glu Ala Val Ala Ala Gly 
    50                  55                  60                  


His Glu Glu Leu Pro Leu Cys Phe Ala Leu Lys Ser His Phe Val Gly 
65                  70                  75                  80  


Ala Val Ile Gly Arg Gly Gly Ser Lys Ile Lys Asn Ile Gln Ser Thr 
                85                  90                  95      


Thr Asn Thr Thr Ile Gln Ile Ile Gln Glu Gln Pro Glu Ser Leu Val 
            100                 105                 110         


Lys Ile Phe Gly Ser Lys Ala Met Gln Thr Lys Ala Lys Ala Val Ile 
        115                 120                 125             


Asp Asn Phe Val Lys Lys Leu Glu Glu Asn Tyr Asn Ser Glu Cys Gly 
    130                 135                 140                 


Ile Asp Thr Ala Phe Gln Pro Ser Val Gly Lys Asp Gly Ser Thr Asp 
145                 150                 155                 160 


Asn Asn Val Val Ala Gly Asp Arg Pro Leu Ile Asp Trp Asp Gln Ile 
                165                 170                 175     


Arg Glu Glu Gly Leu Lys Trp Gln Lys Thr Lys Trp Ala Asp Leu Pro 
            180                 185                 190         


Pro Ile Lys Lys Asn Phe Tyr Lys Glu Ser Thr Ala Thr Ser Ala Met 
        195                 200                 205             


Ser Lys Val Glu Ala Asp Ser Trp Arg Lys Glu Asn Phe Asn Ile Thr 
    210                 215                 220                 


Trp Asp Asp Leu Lys Asp Gly Glu Lys Arg Pro Ile Pro Asn Pro Thr 
225                 230                 235                 240 


Cys Thr Phe Asp Asp Ala Phe Gln Cys Tyr Pro Glu Val Met Glu Asn 
                245                 250                 255     


Ile Lys Lys Ala Gly Phe Gln Lys Pro Thr Pro Ile Gln Ser Gln Ala 
            260                 265                 270         


Trp Pro Ile Val Leu Gln Gly Ile Asp Leu Ile Gly Val Ala Gln Thr 
        275                 280                 285             


Gly Thr Gly Lys Thr Leu Cys Tyr Leu Met Pro Gly Phe Ile His Leu 
    290                 295                 300                 


Val Leu Gln Pro Ser Leu Lys Gly Gln Arg Asn Arg Pro Gly Met Leu 
305                 310                 315                 320 


Val Leu Thr Pro Thr Arg Glu Leu Ala Leu Gln Val Glu Gly Glu Cys 
                325                 330                 335     


Cys Lys Tyr Ser Tyr Lys Gly Leu Arg Ser Val Cys Val Tyr Gly Gly 
            340                 345                 350         


Gly Asn Arg Asp Glu Gln Ile Glu Glu Leu Lys Lys Gly Val Asp Ile 
        355                 360                 365             


Ile Ile Ala Thr Pro Gly Arg Leu Asn Asp Leu Gln Met Ser Asn Phe 
    370                 375                 380                 


Val Asn Leu Lys Asn Ile Thr Tyr Leu Val Leu Asp Glu Ala Asp Lys 
385                 390                 395                 400 


Met Leu Asp Met Gly Phe Glu Pro Gln Ile Met Lys Ile Leu Leu Asp 
                405                 410                 415     


Val Arg Pro Asp Arg Gln Thr Val Met Thr Ser Ala Thr Trp Pro His 
            420                 425                 430         


Ser Val His Arg Leu Ala Gln Ser Tyr Leu Lys Glu Pro Met Ile Val 
        435                 440                 445             


Tyr Val Gly Thr Leu Asp Leu Val Ala Val Ser Ser Val Lys Gln Asn 
    450                 455                 460                 


Ile Ile Val Thr Thr Glu Glu Glu Lys Trp Ser His Met Gln Thr Phe 
465                 470                 475                 480 


Leu Gln Ser Met Ser Ser Thr Asp Lys Val Ile Val Phe Val Ser Arg 
                485                 490                 495     


Lys Ala Val Ala Asp His Leu Ser Ser Asp Leu Ile Leu Gly Asn Ile 
            500                 505                 510         


Ser Val Glu Ser Leu His Gly Asp Arg Glu Gln Arg Asp Arg Glu Lys 
        515                 520                 525             


Ala Leu Glu Asn Phe Lys Thr Gly Lys Val Arg Ile Leu Ile Ala Thr 
    530                 535                 540                 


Asp Leu Ala Ser Arg Gly Leu Asp Val His Asp Val Thr His Val Tyr 
545                 550                 555                 560 


Asn Phe Asp Phe Pro Arg Asn Ile Glu Glu Tyr Val His Arg Ile Gly 
                565                 570                 575     


Arg Thr Gly Arg Ala Gly Arg Thr Gly Val Ser Ile Thr Thr Leu Thr 
            580                 585                 590         


Arg Asn Asp Trp Arg Val Ala Ser Glu Leu Ile Asn Ile Leu Glu Arg 
        595                 600                 605             


Ala Asn Gln Ser Ile Pro Glu Glu Leu Val Ser Met Ala Glu Arg Phe 
    610                 615                 620                 


Lys Ala His Gln Gln Lys Arg Glu Met Glu Arg Lys Met Glu Arg Pro 
625                 630                 635                 640 


Gln Gly Arg Pro Lys Lys Phe His 
                645             


<210>  25
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Trp Arg Gly Arg Ser Thr Tyr Tyr Trp Pro Arg Pro Arg Arg 
1               5                   10                  15      


Tyr Val Gln Pro Pro Glu Met Ile Gly Pro Met Arg Pro Glu Gln Phe 
            20                  25                  30          


Ser Asp Glu Val Glu Pro Ala Thr Pro Glu Glu Gly Glu Pro Ala Thr 
        35                  40                  45              


Gln Arg Gln Asp Pro Ala Ala Ala Gln Glu Gly Glu Asp Glu Gly Ala 
    50                  55                  60                  


Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp Ser Gln Glu Gln Gly 
65                  70                  75                  80  


His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro Asp Gly Gln Glu 
                85                  90                  95      


Met Asp Pro Pro Asn Pro Glu Glu Val Lys Thr Pro Glu Glu Glu Met 
            100                 105                 110         


Arg Ser His Tyr Val Ala Gln Thr Gly Ile Leu Trp Leu Leu Met Asn 
        115                 120                 125             


Asn Cys Phe Leu Asn Leu Ser Pro Arg Lys Pro 
    130                 135                 


<210>  26
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Arg Ala Pro Lys Arg Gln Arg Cys Met Pro Glu Glu Asp Leu 
1               5                   10                  15      


Gln Ser Gln Ser Glu Thr Gln Gly Leu Glu Gly Ala Gln Ala Pro Leu 
            20                  25                  30          


Ala Val Glu Glu Asp Ala Ser Ser Ser Thr Ser Thr Ser Ser Ser Phe 
        35                  40                  45              


Pro Ser Ser Phe Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Cys Tyr 
    50                  55                  60                  


Pro Leu Ile Pro Ser Thr Pro Glu Glu Val Ser Ala Asp Asp Glu Thr 
65                  70                  75                  80  


Pro Asn Pro Pro Gln Ser Ala Gln Ile Ala Cys Ser Ser Pro Ser Val 
                85                  90                  95      


Val Ala Ser Leu Pro Leu Asp Gln Ser Asp Glu Gly Ser Ser Ser Gln 
            100                 105                 110         


Lys Glu Glu Ser Pro Ser Thr Leu Gln Val Leu Pro Asp Ser Glu Ser 
        115                 120                 125             


Leu Pro Arg Ser Glu Ile Asp Glu Lys Val Thr Asp Leu Val Gln Phe 
    130                 135                 140                 


Leu Leu Phe Lys Tyr Gln Met Lys Glu Pro Ile Thr Lys Ala Glu Ile 
145                 150                 155                 160 


Leu Glu Ser Val Ile Arg Asn Tyr Glu Asp His Phe Pro Leu Leu Phe 
                165                 170                 175     


Ser Glu Ala Ser Glu Cys Met Leu Leu Val Phe Gly Ile Asp Val Lys 
            180                 185                 190         


Glu Val Asp Pro Thr Gly His Ser Phe Val Leu Val Thr Ser Leu Gly 
        195                 200                 205             


Leu Thr Tyr Asp Gly Met Leu Ser Asp Val Gln Ser Met Pro Lys Thr 
    210                 215                 220                 


Gly Ile Leu Ile Leu Ile Leu Ser Ile Val Phe Ile Glu Gly Tyr Cys 
225                 230                 235                 240 


Thr Pro Glu Glu Val Ile Trp Glu Ala Leu Asn Met Met Gly Leu Tyr 
                245                 250                 255     


Asp Gly Met Glu His Leu Ile Tyr Gly Glu Pro Arg Lys Leu Leu Thr 
            260                 265                 270         


Gln Asp Trp Val Gln Glu Asn Tyr Leu Glu Tyr Arg Gln Val Pro Gly 
        275                 280                 285             


Ser Asp Pro Ala Arg Tyr Glu Phe Leu Trp Gly Pro Arg Ala His Ala 
    290                 295                 300                 


Glu Ile Arg Lys Met Ser Leu Leu Lys Phe Leu Ala Lys Val Asn Gly 
305                 310                 315                 320 


Ser Asp Pro Arg Ser Phe Pro Leu Trp Tyr Glu Glu Ala Leu Lys Asp 
                325                 330                 335     


Glu Glu Glu Arg Ala Gln Asp Arg Ile Ala Thr Thr Asp Asp Thr Thr 
            340                 345                 350         


Ala Met Ala Ser Ala Ser Ser Ser Ala Thr Gly Ser Phe Ser Tyr Pro 
        355                 360                 365             


Glu 
    


<210>  27
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Val Met Asp Leu Ala Asn Thr Cys Ser Ser Phe Gln Ser Asp 
1               5                   10                  15      


Leu Asp Phe Cys Ser Asp Cys Gly Ser Val Leu Pro Leu Pro Gly Ala 
            20                  25                  30          


Gln Asp Thr Val Thr Cys Ile Arg Cys Gly Phe Asn Ile Asn Val Arg 
        35                  40                  45              


Asp Phe Glu Gly Lys Val Val Lys Thr Ser Val Val Phe His Gln Leu 
    50                  55                  60                  


Gly Thr Ala Met Pro Met Ser Val Glu Glu Gly Pro Glu Cys Gln Gly 
65                  70                  75                  80  


Pro Val Val Asp Arg Arg Cys Pro Arg Cys Gly His Glu Gly Met Ala 
                85                  90                  95      


Tyr His Thr Arg Gln Met Arg Ser Ala Asp Glu Gly Gln Thr Val Phe 
            100                 105                 110         


Tyr Thr Cys Thr Asn Cys Lys Phe Gln Glu Lys Glu Asp Ser 
        115                 120                 125     


<210>  28
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Leu Trp Leu Ala Leu Gly Pro Phe Pro Ala Met Glu Asn Gln Val 
1               5                   10                  15      


Leu Val Ile Arg Ile Lys Ile Pro Asn Ser Gly Ala Val Asp Trp Thr 
            20                  25                  30          


Val His Ser Gly Pro Gln Leu Leu Phe Arg Asp Val Leu Asp Val Ile 
        35                  40                  45              


Gly Gln Val Leu Pro Glu Ala Thr Thr Thr Ala Phe Glu Tyr Glu Asp 
    50                  55                  60                  


Glu Asp Gly Asp Arg Ile Thr Val Arg Ser Asp Glu Glu Met Lys Ala 
65                  70                  75                  80  


Met Leu Ser Tyr Tyr Tyr Ser Thr Val Met Glu Gln Gln Val Asn Gly 
                85                  90                  95      


Gln Leu Ile Glu Pro Leu Gln Ile Phe Pro Arg Ala Cys Lys Pro Pro 
            100                 105                 110         


Gly Glu Arg Asn Ile His Gly Leu Lys Val Asn Thr Arg Ala Gly Pro 
        115                 120                 125             


Ser Gln His Ser Ser Pro Ala Val Ser Asp Ser Leu Pro Ser Asn Ser 
    130                 135                 140                 


Leu Lys Lys Ser Ser Ala Glu Leu Lys Lys Ile Leu Ala Asn Gly Gln 
145                 150                 155                 160 


Met Asn Glu Gln Asp Ile Arg Tyr Arg Asp Thr Leu Gly His Gly Asn 
                165                 170                 175     


Gly Gly Thr Val Tyr Lys Ala Tyr His Val Pro Ser Gly Lys Ile Leu 
            180                 185                 190         


Ala Val Lys Val Ile Leu Leu Asp Ile Thr Leu Glu Leu Gln Lys Gln 
        195                 200                 205             


Ile Met Ser Glu Leu Glu Ile Leu Tyr Lys Cys Asp Ser Ser Tyr Ile 
    210                 215                 220                 


Ile Gly Phe Tyr Gly Ala Phe Phe Val Glu Asn Arg Ile Ser Ile Cys 
225                 230                 235                 240 


Thr Glu Phe Met Asp Gly Gly Ser Leu Asp Val Tyr Arg Lys Met Pro 
                245                 250                 255     


Glu His Val Leu Gly Arg Ile Ala Val Ala Val Val Lys Gly Leu Thr 
            260                 265                 270         


Tyr Leu Trp Ser Leu Lys Ile Leu His Arg Asp Val Lys Pro Ser Asn 
        275                 280                 285             


Met Leu Val Asn Thr Arg Gly Gln Val Lys Leu Cys Asp Phe Gly Val 
    290                 295                 300                 


Ser Thr Gln Leu Val Asn Ser Ile Ala Lys Thr Tyr Val Gly Thr Asn 
305                 310                 315                 320 


Ala Tyr Met Ala Pro Glu Arg Ile Ser Gly Glu Gln Tyr Gly Ile His 
                325                 330                 335     


Ser Asp Val Trp Ser Leu Gly Ile Ser Phe Met Glu Leu Ala Leu Gly 
            340                 345                 350         


Arg Phe Pro Tyr Pro Gln Ile Gln Lys Asn Gln Gly Ser Leu Met Pro 
        355                 360                 365             


Leu Gln Leu Leu Gln Cys Ile Val Asp Glu Asp Ser Pro Val Leu Pro 
    370                 375                 380                 


Val Gly Glu Phe Ser Glu Pro Phe Val His Phe Ile Thr Gln Cys Met 
385                 390                 395                 400 


Arg Lys Gln Pro Lys Glu Arg Pro Ala Pro Glu Glu Leu Met Gly His 
                405                 410                 415     


Pro Phe Ile Val Gln Phe Asn Asp Gly Asn Ala Ala Val Val Ser Met 
            420                 425                 430         


Trp Val Cys Arg Ala Leu Glu Glu Arg Arg Ser Gln Gln Gly Pro Pro 
        435                 440                 445             


<210>  29
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Ser Glu Gln Lys Ser Gln His Cys Lys Pro Glu Glu Gly Val 
1               5                   10                  15      


Glu Ala Gln Glu Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Thr 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Val Ser Ser Ser Ser Pro Leu Val Pro 
        35                  40                  45              


Gly Thr Leu Glu Glu Val Pro Ala Ala Glu Ser Ala Gly Pro Pro Gln 
    50                  55                  60                  


Ser Pro Gln Gly Ala Ser Ala Leu Pro Thr Thr Ile Ser Phe Thr Cys 
65                  70                  75                  80  


Trp Arg Gln Pro Asn Glu Gly Ser Ser Ser Gln Glu Glu Glu Gly Pro 
                85                  90                  95      


Ser Thr Ser Pro Asp Ala Glu Ser Leu Phe Arg Glu Ala Leu Ser Asn 
            100                 105                 110         


Lys Val Asp Glu Leu Ala His Phe Leu Leu Arg Lys Tyr Arg Ala Lys 
        115                 120                 125             


Glu Leu Val Thr Lys Ala Glu Met Leu Glu Arg Val Ile Lys Asn Tyr 
    130                 135                 140                 


Lys Arg Cys Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Ser Leu Lys 
145                 150                 155                 160 


Met Ile Phe Gly Ile Asp Val Lys Glu Val Asp Pro Ala Ser Asn Thr 
                165                 170                 175     


Tyr Thr Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly 
            180                 185                 190         


Asn Asn Gln Ile Phe Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Gly 
        195                 200                 205             


Thr Ile Ala Met Glu Gly Asp Ser Ala Ser Glu Glu Glu Ile Trp Glu 
    210                 215                 220                 


Glu Leu Gly Val Met Gly Val Tyr Asp Gly Arg Glu His Thr Val Tyr 
225                 230                 235                 240 


Gly Glu Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr 
                245                 250                 255     


Leu Glu Tyr Arg Gln Val Pro Gly Ser Asn Pro Ala Arg Tyr Glu Phe 
            260                 265                 270         


Leu Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu 
        275                 280                 285             


Glu His Val Val Arg Val Asn Ala Arg Val Arg Ile Ala Tyr Pro Ser 
    290                 295                 300                 


Leu Arg Glu Ala Ala Leu Leu Glu Glu Glu Glu Gly Val 
305                 310                 315         


<210>  30
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val 
705                 710         


<210>  31
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ser Ala Thr Gly Asp Arg His Pro Thr Gln Gly Asp Gln Glu Ala 
1               5                   10                  15      


Pro Val Ser Gln Glu Gly Ala Gln Ala Glu Ala Ala Gly Ala Gly Asn 
            20                  25                  30          


Gln Glu Gly Gly Asp Ser Gly Pro Asp Ser Ser Asp Val Val Pro Ala 
        35                  40                  45              


Ala Glu Val Val Gly Val Ala Gly Pro Val Glu Gly Leu Gly Glu Glu 
    50                  55                  60                  


Glu Gly Glu Gln Ala Ala Gly Leu Ala Ala Val Pro Arg Gly Gly Ser 
65                  70                  75                  80  


Ala Glu Glu Asp Ser Asp Ile Gly Pro Ala Thr Glu Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Gly Asn Glu Ala Ala Asn Phe Asp Leu Ala Val Val Ala Arg 
            100                 105                 110         


Arg Tyr Pro Ala Ser Gly Ile His Phe Val Leu Leu Asp Met Val His 
        115                 120                 125             


Ser Leu Leu His Arg Leu Ser His Asn Asp His Ile Leu Ile Glu Asn 
    130                 135                 140                 


Arg Gln Leu Ser Arg Leu Met Val Gly Pro His Ala Ala Ala Arg Asn 
145                 150                 155                 160 


Leu Trp Gly Asn Leu Pro Pro Leu Leu Leu Pro Gln Arg Leu Gly Ala 
                165                 170                 175     


Gly Ala Ala Ala Arg Ala Gly Glu Gly Leu Gly Leu Ile Gln Glu Ala 
            180                 185                 190         


Ala Ser Val Pro Glu Pro Ala Val Pro Ala Asp Leu Ala Glu Met Ala 
        195                 200                 205             


Arg Glu Pro Ala Glu Glu Ala Ala Glu Glu Lys Leu Ser Glu Glu Ala 
    210                 215                 220                 


Thr Glu Glu Pro Asp Ala Glu Glu Pro Ala Thr Glu Glu Pro Thr Ala 
225                 230                 235                 240 


Gln Glu Ala Thr Ala Pro Glu Glu Val Thr Lys Ser Gln Pro Glu Lys 
                245                 250                 255     


Trp Asp Glu Glu Ala Gln Asp Ala Ala Gly Glu Glu Glu Lys Glu Gln 
            260                 265                 270         


Glu Lys Glu Lys Asp Ala Glu Asn Lys Val Lys Asn Ser Lys Gly Thr 
        275                 280                 285             


<210>  32
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asn Lys Leu Tyr Ile Gly Asn Leu Ser Glu Asn Ala Ala Pro Ser 
1               5                   10                  15      


Asp Leu Glu Ser Ile Phe Lys Asp Ala Lys Ile Pro Val Ser Gly Pro 
            20                  25                  30          


Phe Leu Val Lys Thr Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu Ser 
        35                  40                  45              


Trp Ala Leu Lys Ala Ile Glu Ala Leu Ser Gly Lys Ile Glu Leu His 
    50                  55                  60                  


Gly Lys Pro Ile Glu Val Glu His Ser Val Pro Lys Arg Gln Arg Ile 
65                  70                  75                  80  


Arg Lys Leu Gln Ile Arg Asn Ile Pro Pro His Leu Gln Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Val Gln Tyr Gly Val Val Glu Ser Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Asp Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Ser 
        115                 120                 125             


Lys Asp Gln Ala Arg Gln Ala Leu Asp Lys Leu Asn Gly Phe Gln Leu 
    130                 135                 140                 


Glu Asn Phe Thr Leu Lys Val Ala Tyr Ile Pro Asp Glu Met Ala Ala 
145                 150                 155                 160 


Gln Gln Asn Pro Leu Gln Gln Pro Arg Gly Arg Arg Gly Leu Gly Gln 
                165                 170                 175     


Arg Gly Ser Ser Arg Gln Gly Ser Pro Gly Ser Val Ser Lys Gln Lys 
            180                 185                 190         


Pro Cys Asp Leu Pro Leu Arg Leu Leu Val Pro Thr Gln Phe Val Gly 
        195                 200                 205             


Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile Thr Lys Gln 
    210                 215                 220                 


Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala Gly Ala Ala 
225                 230                 235                 240 


Glu Lys Ser Ile Thr Ile Leu Ser Thr Pro Glu Gly Thr Ser Ala Ala 
                245                 250                 255     


Cys Lys Ser Ile Leu Glu Ile Met His Lys Glu Ala Gln Asp Ile Lys 
            260                 265                 270         


Phe Thr Glu Glu Ile Pro Leu Lys Ile Leu Ala His Asn Asn Phe Val 
        275                 280                 285             


Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Ile Glu Gln 
    290                 295                 300                 


Asp Thr Asp Thr Lys Ile Thr Ile Ser Pro Leu Gln Glu Leu Thr Leu 
305                 310                 315                 320 


Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Asn Val Glu Thr Cys 
                325                 330                 335     


Ala Lys Ala Glu Glu Glu Ile Met Lys Lys Ile Arg Glu Ser Tyr Glu 
            340                 345                 350         


Asn Asp Ile Ala Ser Met Asn Leu Gln Ala His Leu Ile Pro Gly Leu 
        355                 360                 365             


Asn Leu Asn Ala Leu Gly Leu Phe Pro Pro Thr Ser Gly Met Pro Pro 
    370                 375                 380                 


Pro Thr Ser Gly Pro Pro Ser Ala Met Thr Pro Pro Tyr Pro Gln Phe 
385                 390                 395                 400 


Glu Gln Ser Glu Thr Glu Thr Val His Leu Phe Ile Pro Ala Leu Ser 
                405                 410                 415     


Val Gly Ala Ile Ile Gly Lys Gln Gly Gln His Ile Lys Gln Leu Ser 
            420                 425                 430         


Arg Phe Ala Gly Ala Ser Ile Lys Ile Ala Pro Ala Glu Ala Pro Asp 
        435                 440                 445             


Ala Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe 
    450                 455                 460                 


Lys Ala Gln Gly Arg Ile Tyr Gly Lys Ile Lys Glu Glu Asn Phe Val 
465                 470                 475                 480 


Ser Pro Lys Glu Glu Val Lys Leu Glu Ala His Ile Arg Val Pro Ser 
                485                 490                 495     


Phe Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu 
            500                 505                 510         


Leu Gln Asn Leu Ser Ser Ala Glu Val Val Val Pro Arg Asp Gln Thr 
        515                 520                 525             


Pro Asp Glu Asn Asp Gln Val Val Val Lys Ile Thr Gly His Phe Tyr 
    530                 535                 540                 


Ala Cys Gln Val Ala Gln Arg Lys Ile Gln Glu Ile Leu Thr Gln Val 
545                 550                 555                 560 


Lys Gln His Gln Gln Gln Lys Ala Leu Gln Ser Gly Pro Pro Gln Ser 
                565                 570                 575     


Arg Arg Lys 
            


<210>  33
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gln Ala Glu Gly Gln Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Arg Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Ala Gln Asp Gly Arg Cys Pro Cys Gly Ala 
65                  70                  75                  80  


Arg Arg Pro Asp Ser Arg Leu Leu Gln Leu His Ile Thr Met Pro Phe 
                85                  90                  95      


Ser Ser Pro Met Glu Ala Glu Leu Val Arg Arg Ile Leu Ser Arg Asp 
            100                 105                 110         


Ala Ala Pro Leu Pro Arg Pro Gly Ala Val Leu Lys Asp Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Leu Leu Phe Met Ser Val Arg Asp Gln Asp Arg Glu Gly 
    130                 135                 140                 


Ala Gly Arg Met Arg Val Val Gly Trp Gly Leu Gly Ser Ala Ser Pro 
145                 150                 155                 160 


Glu Gly Gln Lys Ala Arg Asp Leu Arg Thr Pro Lys His Lys Val Ser 
                165                 170                 175     


Glu Gln Arg Pro Gly Thr Pro Gly Pro Pro Pro Pro Glu Gly Ala Gln 
            180                 185                 190         


Gly Asp Gly Cys Arg Gly Val Ala Phe Asn Val Met Phe Ser Ala Pro 
        195                 200                 205             


His Ile 
    210 


<210>  34
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gln Val Thr Leu Lys Thr Leu Gln Gln Gln Thr Phe Lys Ile Asp 
1               5                   10                  15      


Ile Asp Pro Glu Glu Thr Val Lys Ala Leu Lys Glu Lys Ile Glu Ser 
            20                  25                  30          


Glu Lys Gly Lys Asp Ala Phe Pro Val Ala Gly Gln Lys Leu Ile Tyr 
        35                  40                  45              


Ala Gly Lys Ile Leu Asn Asp Asp Thr Ala Leu Lys Glu Tyr Lys Ile 
    50                  55                  60                  


Asp Glu Lys Asn Phe Val Val Val Met Val Thr Lys Pro Lys Ala Val 
65                  70                  75                  80  


Ser Thr Pro Ala Pro Ala Thr Thr Gln Gln Ser Ala Pro Ala Ser Thr 
                85                  90                  95      


Thr Ala Val Thr Ser Ser Thr Thr Thr Thr Val Ala Gln Ala Pro Thr 
            100                 105                 110         


Pro Val Pro Ala Leu Ala Pro Thr Ser Thr Pro Ala Ser Ile Thr Pro 
        115                 120                 125             


Ala Ser Ala Thr Ala Ser Ser Glu Pro Ala Pro Ala Ser Ala Ala Lys 
    130                 135                 140                 


Gln Glu Lys Pro Ala Glu Lys Pro Ala Glu Thr Pro Val Ala Thr Ser 
145                 150                 155                 160 


Pro Thr Ala Thr Asp Ser Thr Ser Gly Asp Ser Ser Arg Ser Asn Leu 
                165                 170                 175     


Phe Glu Asp Ala Thr Ser Ala Leu Val Thr Gly Gln Ser Tyr Glu Asn 
            180                 185                 190         


Met Val Thr Glu Ile Met Ser Met Gly Tyr Glu Arg Glu Gln Val Ile 
        195                 200                 205             


Ala Ala Leu Arg Ala Ser Phe Asn Asn Pro Asp Arg Ala Val Glu Tyr 
    210                 215                 220                 


Leu Leu Met Gly Ile Pro Gly Asp Arg Glu Ser Gln Ala Val Val Asp 
225                 230                 235                 240 


Pro Pro Gln Ala Ala Ser Thr Gly Ala Pro Gln Ser Ser Ala Val Ala 
                245                 250                 255     


Ala Ala Ala Ala Thr Thr Thr Ala Thr Thr Thr Thr Thr Ser Ser Gly 
            260                 265                 270         


Gly His Pro Leu Glu Phe Leu Arg Asn Gln Pro Gln Phe Gln Gln Met 
        275                 280                 285             


Arg Gln Ile Ile Gln Gln Asn Pro Ser Leu Leu Pro Ala Leu Leu Gln 
    290                 295                 300                 


Gln Ile Gly Arg Glu Asn Pro Gln Leu Leu Gln Gln Ile Ser Gln His 
305                 310                 315                 320 


Gln Glu His Phe Ile Gln Met Leu Asn Glu Pro Val Gln Glu Ala Gly 
                325                 330                 335     


Gly Gln Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Ala Glu Ala 
            340                 345                 350         


Gly Ser Gly His Met Asn Tyr Ile Gln Val Thr Pro Gln Glu Lys Glu 
        355                 360                 365             


Ala Ile Glu Arg Leu Lys Ala Leu Gly Phe Pro Glu Gly Leu Val Ile 
    370                 375                 380                 


Gln Ala Tyr Phe Ala Cys Glu Lys Asn Glu Asn Leu Ala Ala Asn Phe 
385                 390                 395                 400 


Leu Leu Gln Gln Asn Phe Asp Glu Asp 
                405                 


<210>  35
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asp Pro Phe Leu Val Leu Leu His Ser Val Ser Ser Ser Leu Ser 
1               5                   10                  15      


Ser Ser Glu Leu Thr Glu Leu Lys Phe Leu Cys Leu Gly Arg Val Gly 
            20                  25                  30          


Lys Arg Lys Leu Glu Arg Val Gln Ser Gly Leu Asp Leu Phe Ser Met 
        35                  40                  45              


Leu Leu Glu Gln Asn Asp Leu Glu Pro Gly His Thr Glu Leu Leu Arg 
    50                  55                  60                  


Glu Leu Leu Ala Ser Leu Arg Arg His Asp Leu Leu Arg Arg Val Asp 
65                  70                  75                  80  


Asp Phe Glu Ala Gly Ala Ala Ala Gly Ala Ala Pro Gly Glu Glu Asp 
                85                  90                  95      


Leu Cys Ala Ala Phe Asn Val Ile Cys Asp Asn Val Gly Lys Asp Trp 
            100                 105                 110         


Arg Arg Leu Ala Arg Gln Leu Lys Val Ser Asp Thr Lys Ile Asp Ser 
        115                 120                 125             


Ile Glu Asp Arg Tyr Pro Arg Asn Leu Thr Glu Arg Val Arg Glu Ser 
    130                 135                 140                 


Leu Arg Ile Trp Lys Asn Thr Glu Lys Glu Asn Ala Thr Val Ala His 
145                 150                 155                 160 


Leu Val Gly Ala Leu Arg Ser Cys Gln Met Asn Leu Val Ala Asp Leu 
                165                 170                 175     


Val Gln Glu Val Gln Gln Ala Arg Asp Leu Gln Asn Arg Ser Gly Ala 
            180                 185                 190         


Met Ser Pro Met Ser Trp Asn Ser Asp Ala Ser Thr Ser Glu Ala Ser 
        195                 200                 205             


<210>  36
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Ser Pro Arg Asp Phe Arg Ala Glu Pro Val Asn Asp Tyr Glu 
1               5                   10                  15      


Gly Asn Asp Ser Glu Ala Glu Asp Leu Asn Phe Arg Glu Thr Leu Pro 
            20                  25                  30          


Ser Ser Ser Gln Glu Asn Thr Pro Arg Ser Lys Val Phe Glu Asn Lys 
        35                  40                  45              


Val Asn Ser Glu Lys Val Lys Leu Ser Leu Arg Asn Phe Pro His Asn 
    50                  55                  60                  


Asp Tyr Glu Asp Val Phe Glu Glu Pro Ser Glu Ser Gly Ser Asp Pro 
65                  70                  75                  80  


Ser Met Trp Thr Ala Arg Gly Pro Phe Arg Arg Asp Arg Trp Ser Ser 
                85                  90                  95      


Glu Asp Glu Glu Ala Ala Gly Pro Ser Gln Ala Leu Ser Pro Leu Leu 
            100                 105                 110         


Ser Asp Thr Arg Lys Ile Val Ser Glu Gly Glu Leu Asp Gln Leu Ala 
        115                 120                 125             


Gln Ile Arg Pro Leu Ile Phe Asn Phe His Glu Gln Thr Ala Ile Lys 
    130                 135                 140                 


Asp Cys Leu Lys Ile Leu Glu Glu Lys Thr Ala Ala Tyr Asp Ile Met 
145                 150                 155                 160 


Gln Glu Phe Met Ala Leu Glu Leu Lys Asn Leu Pro Gly Glu Phe Asn 
                165                 170                 175     


Ser Gly Asn Gln Pro Ser Asn Arg Glu Lys Asn Arg Tyr Arg Asp Ile 
            180                 185                 190         


Leu Pro Tyr Asp Ser Thr Arg Val Pro Leu Gly Lys Ser Lys Asp Tyr 
        195                 200                 205             


Ile Asn Ala Ser Tyr Ile Arg Ile Val Asn Cys Gly Glu Glu Tyr Phe 
    210                 215                 220                 


Tyr Ile Ala Thr Gln Gly Pro Leu Leu Ser Thr Ile Asp Asp Phe Trp 
225                 230                 235                 240 


Gln Met Val Leu Glu Asn Asn Ser Asn Val Ile Ala Met Ile Thr Arg 
                245                 250                 255     


Glu Ile Glu Gly Gly Ile Ile Lys Cys Tyr His Tyr Trp Pro Ile Ser 
            260                 265                 270         


Leu Lys Lys Pro Leu Glu Leu Lys His Phe Arg Val Phe Leu Glu Asn 
        275                 280                 285             


Tyr Gln Ile Leu Gln Tyr Phe Ile Ile Arg Met Phe Gln Val Val Glu 
    290                 295                 300                 


Lys Ser Thr Gly Thr Ser His Ser Val Lys Gln Leu Gln Phe Thr Lys 
305                 310                 315                 320 


Trp Pro Asp His Gly Thr Pro Ala Ser Ala Asp Ser Phe Ile Lys Tyr 
                325                 330                 335     


Ile Arg Tyr Ala Arg Lys Ser His Leu Thr Gly Pro Met Val Val His 
            340                 345                 350         


Cys Ser Ala Gly Ile Gly Arg Thr Gly Val Phe Leu Cys Val Asp Val 
        355                 360                 365             


Val Phe Cys Ala Ile Val Lys Asn Cys Ser Phe Asn Ile Met Asp Ile 
    370                 375                 380                 


Val Ala Gln Met Arg Glu Gln Arg Ser Gly Met Val Gln Thr Lys Glu 
385                 390                 395                 400 


Gln Tyr His Phe Cys Tyr Asp Ile Val Leu Glu Val Leu Arg Lys Leu 
                405                 410                 415     


Leu Thr Leu Asp 
            420 


<210>  37
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu 
1               5                   10                  15      


Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala 
            20                  25                  30          


Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys 
        35                  40                  45              


Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu 
    50                  55                  60                  


Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp 
65                  70                  75                  80  


Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu 
                85                  90                  95      


Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
            100                 105                 110         


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
        115                 120                 125             


Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln 
    130                 135                 140                 


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg 
145                 150                 155                 160 


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu 
                165                 170                 175     


Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu 
            180                 185                 190         


Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu 
        195                 200                 205             


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu 
    210                 215                 220                 


Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
225                 230                 235                 240 


Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu 
                245                 250                 255     


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
            260                 265                 270         


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 


<210>  38
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


