                         SEQUENCE LISTING

<110>  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
       VAKNIN-DEMBINSKY, Adi
       LAVON BEN MOSHE, Iris
 
<120>  MARKERS OF DISEASE PROGNOSIS IN MULTIPLE SCLEROSIS

<130>  HDST/060 PCT

<150>  62/778325
<151>  2018-12-12

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  1
tcctcctcag accgctttt                                                    19


<210>  2
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  2
cctggttcat catcgctaat c                                                 21


<210>  3
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  3
tcacattggc aatcatcaca gtg                                               23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  4
cgttcttgtc cagatactgg agt                                               23


<210>  5
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  5
ctgctgctgc tactacttac aagg                                              24


<210>  6
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  6
agacgggcac gaggttcc                                                     18


<210>  7
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  7
ggaggtccta gaaagctcag tg                                                22


<210>  8
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  8
cgatgactgc tgtgcagatg a                                                 21


<210>  9
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  9
catccctgtc ttctgcaaag caa                                               23


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  10
cagtggcttt gcctggagat                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  11
cggccaggat ggttcttaga c                                                 21


<210>  12
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligonucleotide

<400>  12
gagaagctgc aggtgaaggt                                                   20


<210>  13
<211>  1995
<212>  DNA
<213>  Homo sapiens

<400>  13
acaggggtga aggcccagag accagcagaa cggcatccca gccacgacgg ccactttgct       60

ctgtctgctc tccgccacgg ccctgctctg ttccctggga cacccccgcc cccacctcct      120

caggctgcct gatctgccca gctttccagc tttcctctgg attccggcct ctggtcatcc      180

ctccccaccc tctctccaag gccctctcct ggtctccctt cttctagaac cccttcctcc      240

acctccctct ctgcagaact tctcctttac cccccacccc ccaccactgc cccctttcct      300

tttctgacct ccttttggag ggctcagcgc tgcccagacc ataggagaga tgtgggaggc      360

tcagttcctg ggcttgctgt ttctgcagcc gctttgggtg gctccagtga agcctctcca      420

gccaggggct gaggtcccgg tggtgtgggc ccaggagggg gctcctgccc agctcccctg      480

cagccccaca atccccctcc aggatctcag ccttctgcga agagcagggg tcacttggca      540

gcatcagcca gacagtggcc cgcccgctgc cgcccccggc catcccctgg cccccggccc      600

tcacccggcg gcgccctcct cctgggggcc caggccccgc cgctacacgg tgctgagcgt      660

gggtcccgga ggcctgcgca gcgggaggct gcccctgcag ccccgcgtcc agctggatga      720

gcgcggccgg cagcgcgggg acttctcgct atggctgcgc ccagcccggc gcgcggacgc      780

cggcgagtac cgcgccgcgg tgcacctcag ggaccgcgcc ctctcctgcc gcctccgtct      840

gcgcctgggc caggcctcga tgactgccag ccccccagga tctctcagag cctccgactg      900

ggtcattttg aactgctcct tcagccgccc tgaccgccca gcctctgtgc attggttccg      960

gaaccggggc cagggccgag tccctgtccg ggagtccccc catcaccact tagcggaaag     1020

cttcctcttc ctgccccaag tcagccccat ggactctggg ccctggggct gcatcctcac     1080

ctacagagat ggcttcaacg tctccatcat gtataacctc actgttctgg gtctggagcc     1140

cccaactccc ttgacagtgt acgctggagc aggttccagg gtggggctgc cctgccgcct     1200

gcctgctggt gtggggaccc ggtctttcct cactgccaag tggactcctc ctgggggagg     1260

ccctgacctc ctggtgactg gagacaatgg cgactttacc cttcgactag aggatgtgag     1320

ccaggcccag gctgggacct acacctgcca tatccatctg caggaacagc agctcaatgc     1380

cactgtcaca ttggcaatca tcacagtgac tcccaaatcc tttgggtcac ctggatccct     1440

ggggaagctg ctttgtgagg tgactccagt atctggacaa gaacgctttg tgtggagctc     1500

tctggacacc ccatcccaga ggagtttctc aggaccttgg ctggaggcac aggaggccca     1560

gctcctttcc cagccttggc aatgccagct gtaccagggg gagaggcttc ttggagcagc     1620

agtgtacttc acagagctgt ctagcccagg tgcccaacgc tctgggagag ccccaggtgc     1680

cctcccagca ggccacctcc tgctgtttct catccttggt gtcctttctc tgctcctttt     1740

ggtgactgga gcctttggct ttcacctttg gagaagacag tggcgaccaa gacgattttc     1800

tgccttagag caagggattc accctccgca ggctcagagc aagatagagg agctggagca     1860

agaaccggag ccggagccgg agccggaacc ggagcccgag cccgagcccg agccggagca     1920

gctctgacct ggagctgagg cagccagcag atctcagcag cccagtccaa ataaactccc     1980

tgtcagcagc aaaaa                                                      1995


<210>  14
<211>  2448
<212>  DNA
<213>  Homo sapiens

<400>  14
agaacactta caggatgtgt gtagtgtggc atgacagaga actttggttt cctttaatgt       60

gactgtagac ctggcagtgt tactataaga atcactggca atcagacacc cgggtgtgct      120

gagctagcac tcagtggggg cggctactgc tcatgtgatt gtggagtaga cagttggaag      180

aagtacccag tccatttgga gagttaaaac tgtgcctaac agaggtgtcc tctgactttt      240

cttctgcaag ctccatgttt tcacatcttc cctttgactg tgtcctgctg ctgctgctgc      300

tactacttac aaggtcctca gaagtggaat acagagcgga ggtcggtcag aatgcctatc      360

tgccctgctt ctacacccca gccgccccag ggaacctcgt gcccgtctgc tggggcaaag      420

gagcctgtcc tgtgtttgaa tgtggcaacg tggtgctcag gactgatgaa agggatgtga      480

attattggac atccagatac tggctaaatg gggatttccg caaaggagat gtgtccctga      540

ccatagagaa tgtgactcta gcagacagtg ggatctactg ctgccggatc caaatcccag      600

gcataatgaa tgatgaaaaa tttaacctga agttggtcat caaaccagcc aaggtcaccc      660

ctgcaccgac tcggcagaga gacttcactg cagcctttcc aaggatgctt accaccaggg      720

gacatggccc agcagagaca cagacactgg ggagcctccc tgatataaat ctaacacaaa      780

tatccacatt ggccaatgag ttacgggact ctagattggc caatgactta cgggactctg      840

gagcaaccat cagaataggc atctacatcg gagcagggat ctgtgctggg ctggctctgg      900

ctcttatctt cggcgcttta attttcaaat ggtattctca tagcaaagag aagatacaga      960

atttaagcct catctctttg gccaacctcc ctccctcagg attggcaaat gcagtagcag     1020

agggaattcg ctcagaagaa aacatctata ccattgaaga gaacgtatat gaagtggagg     1080

agcccaatga gtattattgc tatgtcagca gcaggcagca accctcacaa cctttgggtt     1140

gtcgctttgc aatgccatag atccaaccac cttatttttg agcttggtgt tttgtctttt     1200

tcagaaacta tgagctgtgt cacctgactg gttttggagg ttctgtccac tgctatggag     1260

cagagttttc ccattttcag aagataatga ctcacatggg aattgaactg ggacctgcac     1320

tgaacttaaa caggcatgtc attgcctctg tatttaagcc aacagagtta cccaacccag     1380

agactgttaa tcatggatgt tagagctcaa acgggctttt atatacacta ggaattcttg     1440

acgtggggtc tctggagctc caggaaattc gggcacatca tatgtccatg aaacttcaga     1500

taaactaggg aaaactgggt gctgaggtga aagcataact tttttggcac agaaagtcta     1560

aaggggccac tgattttcaa agagatctgt gatccctttt tgttttttgt ttttgagatg     1620

gagtcttgct ctgttgccca ggctggagtg caatggcaca atctcggctc actgcaagct     1680

ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc tgagtggctg ggattacagg     1740

catgcaccac catgcccagc taatttgttg tatttttagt agagacaggg tttcaccatg     1800

ttggccagtg tggtctcaaa ctcctgacct catgatttgc ctgcctcggc ctcccaaagc     1860

actgggatta caggcgtgag ccaccacatc cagccagtga tccttaaaag attaagagat     1920

gactggacca ggtctacctt gatcttgaag attcccttgg aatgttgaga tttaggctta     1980

tttgagcact gcctgcccaa ctgtcagtgc cagtgcatag cccttctttt gtctccctta     2040

tgaagactgc cctgcagggc tgagatgtgg caggagctcc cagggaaaaa cgaagtgcat     2100

ttgattggtg tgtattggcc aagttttgct tgttgtgtgc ttgaaagaaa atatctctga     2160

ccaacttctg tattcgtgga ccaaactgaa gctatatttt tcacagaaga agaagcagtg     2220

acggggacac aaattctgtt gcctggtgga aagaaggcaa aggccttcag caatctatat     2280

taccagcgct ggatcctttg acagagagtg gtccctaaac ttaaatttca agacggtata     2340

ggcttgatct gtcttgctta ttgttgcccc ctgcgcctag cacaattctg acacacaatt     2400

ggaacttact aaaaattttt ttttactgtt aaaaaaaaaa aaaaaaaa                  2448


<210>  15
<211>  2033
<212>  DNA
<213>  Homo sapiens

<400>  15
cttctgtgtg tgcacatgtg taatacatat ctgggatcaa agctatctat ataaagtcct       60

tgattctgtg tgggttcaaa cacatttcaa agcttcagga tcctgaaagg ttttgctcta      120

cttcctgaag acctgaacac cgctcccata aagccatggc ttgccttgga tttcagcggc      180

acaaggctca gctgaacctg gctaccagga cctggccctg cactctcctg ttttttcttc      240

tcttcatccc tgtcttctgc aaagcaatgc acgtggccca gcctgctgtg gtactggcca      300

gcagccgagg catcgccagc tttgtgtgtg agtatgcatc tccaggcaaa gccactgagg      360

tccgggtgac agtgcttcgg caggctgaca gccaggtgac tgaagtctgt gcggcaacct      420

acatgatggg gaatgagttg accttcctag atgattccat ctgcacgggc acctccagtg      480

gaaatcaagt gaacctcact atccaaggac tgagggccat ggacacggga ctctacatct      540

gcaaggtgga gctcatgtac ccaccgccat actacctggg cataggcaac ggaacccaga      600

tttatgtaat tgatccagaa ccgtgcccag attctgactt cctcctctgg atccttgcag      660

cagttagttc ggggttgttt ttttatagct ttctcctcac agctgtttct ttgagcaaaa      720

tgctaaagaa aagaagccct cttacaacag gggtctatgt gaaaatgccc ccaacagagc      780

cagaatgtga aaagcaattt cagccttatt ttattcccat caattgagaa accattatga      840

agaagagagt ccatatttca atttccaaga gctgaggcaa ttctaacttt tttgctatcc      900

agctattttt atttgtttgt gcatttgggg ggaattcatc tctctttaat ataaagttgg      960

atgcggaacc caaattacgt gtactacaat ttaaagcaaa ggagtagaaa gacagagctg     1020

ggatgtttct gtcacatcag ctccactttc agtgaaagca tcacttggga ttaatatggg     1080

gatgcagcat tatgatgtgg gtcaaggaat taagttaggg aatggcacag cccaaagaag     1140

gaaaaggcag ggagcgaggg agaagactat attgtacaca ccttatattt acgtatgaga     1200

cgtttatagc cgaaatgatc ttttcaagtt aaattttatg ccttttattt cttaaacaaa     1260

tgtatgatta catcaaggct tcaaaaatac tcacatggct atgttttagc cagtgatgct     1320

aaaggttgta ttgcatatat acatatatat atatatatat atatatatat atatatatat     1380

atatatatat atatatattt taatttgata gtattgtgca tagagccacg tatgtttttg     1440

tgtatttgtt aatggtttga atataaacac tatatggcag tgtctttcca ccttgggtcc     1500

cagggaagtt ttgtggagga gctcaggaca ctaatacacc aggtagaaca caaggtcatt     1560

tgctaactag cttggaaact ggatgaggtc atagcagtgc ttgattgcgt ggaattgtgc     1620

tgagttggtg ttgacatgtg ctttggggct tttacaccag ttcctttcaa tggtttgcaa     1680

ggaagccaca gctggtggta tctgagttga cttgacagaa cactgtcttg aagacaatgg     1740

cttactccag gagacccaca ggtatgacct tctaggaagc tccagttcga tgggcccaat     1800

tcttacaaac atgtggttaa tgccatggac agaagaaggc agcaggtggc agaatggggt     1860

gcatgaaggt ttctgaaaat taacactgct tgtgttttta actcaatatt ttccatgaaa     1920

atgcaacaac atgtataata tttttaatta aataaaaatc tgtggtggtc gttttaaaaa     1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            2033


<210>  16
<211>  2115
<212>  DNA
<213>  Homo sapiens

<400>  16
agtttccctt ccgctcacct ccgcctgagc agtggagaag gcggcactct ggtggggctg       60

ctccaggcat gcagatccca caggcgccct ggccagtcgt ctgggcggtg ctacaactgg      120

gctggcggcc aggatggttc ttagactccc cagacaggcc ctggaacccc cccaccttct      180

ccccagccct gctcgtggtg accgaagggg acaacgccac cttcacctgc agcttctcca      240

acacatcgga gagcttcgtg ctaaactggt accgcatgag ccccagcaac cagacggaca      300

agctggccgc cttccccgag gaccgcagcc agcccggcca ggactgccgc ttccgtgtca      360

cacaactgcc caacgggcgt gacttccaca tgagcgtggt cagggcccgg cgcaatgaca      420

gcggcaccta cctctgtggg gccatctccc tggcccccaa ggcgcagatc aaagagagcc      480

tgcgggcaga gctcagggtg acagagagaa gggcagaagt gcccacagcc caccccagcc      540

cctcacccag gccagccggc cagttccaaa ccctggtggt tggtgtcgtg ggcggcctgc      600

tgggcagcct ggtgctgcta gtctgggtcc tggccgtcat ctgctcccgg gccgcacgag      660

ggacaatagg agccaggcgc accggccagc ccctgaagga ggacccctca gccgtgcctg      720

tgttctctgt ggactatggg gagctggatt tccagtggcg agagaagacc ccggagcccc      780

ccgtgccctg tgtccctgag cagacggagt atgccaccat tgtctttcct agcggaatgg      840

gcacctcatc ccccgcccgc aggggctcag ctgacggccc tcggagtgcc cagccactga      900

ggcctgagga tggacactgc tcttggcccc tctgaccggc ttccttggcc accagtgttc      960

tgcagaccct ccaccatgag cccgggtcag cgcatttcct caggagaagc aggcagggtg     1020

caggccattg caggccgtcc aggggctgag ctgcctgggg gcgaccgggg ctccagcctg     1080

cacctgcacc aggcacagcc ccaccacagg actcatgtct caatgcccac agtgagccca     1140

ggcagcaggt gtcaccgtcc cctacaggga gggccagatg cagtcactgc ttcaggtcct     1200

gccagcacag agctgcctgc gtccagctcc ctgaatctct gctgctgctg ctgctgctgc     1260

tgctgctgcc tgcggcccgg ggctgaaggc gccgtggccc tgcctgacgc cccggagcct     1320

cctgcctgaa cttgggggct ggttggagat ggccttggag cagccaaggt gcccctggca     1380

gtggcatccc gaaacgccct ggacgcaggg cccaagactg ggcacaggag tgggaggtac     1440

atggggctgg ggactcccca ggagttatct gctccctgca ggcctagaga agtttcaggg     1500

aaggtcagaa gagctcctgg ctgtggtggg cagggcagga aacccctcca cctttacaca     1560

tgcccaggca gcacctcagg ccctttgtgg ggcagggaag ctgaggcagt aagcgggcag     1620

gcagagctgg aggcctttca ggcccagcca gcactctggc ctcctgccgc cgcattccac     1680

cccagcccct cacaccactc gggagaggga catcctacgg tcccaaggtc aggagggcag     1740

ggctggggtt gactcaggcc cctcccagct gtggccacct gggtgttggg agggcagaag     1800

tgcaggcacc tagggccccc catgtgccca ccctgggagc tctccttgga acccattcct     1860

gaaattattt aaaggggttg gccgggctcc caccagggcc tgggtgggaa ggtacaggcg     1920

ttcccccggg gcctagtacc cccgccgtgg cctatccact cctcacatcc acacactgca     1980

cccccactcc tggggcaggg ccaccagcat ccaggcggcc agcaggcacc tgagtggctg     2040

ggacaaggga tcccccttcc ctgtggttct attatattat aattataatt aaatatgaga     2100

gcatgctaag gaaaa                                                      2115


<210>  17
<211>  2978
<212>  DNA
<213>  Homo sapiens

<400>  17
cgtcctatct gcagtcggct actttcagtg gcagaagagg ccacatctgc ttcctgtagg       60

ccctctgggc agaagcatgc gctggtgtct cctcctgatc tgggcccagg ggctgaggca      120

ggctcccctc gcctcaggaa tgatgacagg cacaatagaa acaacgggga acatttctgc      180

agagaaaggt ggctctatca tcttacaatg tcacctctcc tccaccacgg cacaagtgac      240

ccaggtcaac tgggagcagc aggaccagct tctggccatt tgtaatgctg acttggggtg      300

gcacatctcc ccatccttca aggatcgagt ggccccaggt cccggcctgg gcctcaccct      360

ccagtcgctg accgtgaacg atacagggga gtacttctgc atctatcaca cctaccctga      420

tgggacgtac actgggagaa tcttcctgga ggtcctagaa agctcagtgg ctgagcacgg      480

tgccaggttc cagattccat tgcttggagc catggccgcg acgctggtgg tcatctgcac      540

agcagtcatc gtggtggtcg cgttgactag aaagaagaaa gccctcagaa tccattctgt      600

ggaaggtgac ctcaggagaa aatcagctgg acaggaggaa tggagcccca gtgctccctc      660

acccccagga agctgtgtcc aggcagaagc tgcacctgct gggctctgtg gagagcagcg      720

gggagaggac tgtgccgagc tgcatgacta cttcaatgtc ctgagttaca gaagcctggg      780

taactgcagc ttcttcacag agactggtta gcaaccagag gcatcttctg gaagatacac      840

ttttgtcttt gctattatag atgaatatat aagcagctgt actctccatc agtgctgcgt      900

gtgtgtgtgt gtgtgtatgt gtgtgtgtgt tcagttgagt gaataaatgt catcctcttc      960

tccatcttca tttccttggc cttttcgttc tattccattt tgcattatgg caggcctagg     1020

gtgagtaacg tggatcttga tcataaatgc aaaattaaaa aatatcttga cctggtttta     1080

aatctggcag tttgagcaga tcctatgtct ctgagagaca cattcctcat aatggccagc     1140

attttgggct acaaggtttt gtggttgatg atgaggatgg catgactgca gagccatcct     1200

catctcattt tttcacgtca ttttcagtaa ctttcactca ttcaaaggca ggttataagt     1260

aagtcctggt agcagcctct atggggagat ttgagagtga ctaaatcttg gtatctgccc     1320

tcaagaactt acagttaaat ggggagacaa tgttgtcatg aaaaggtatt atagtaagga     1380

gagaaggaga catacacagg ccttcaggaa gagacgacag tttggggtga ggtagttggc     1440

ataggcttat ctgtgatgaa gtggcctggg agcaccaagg ggatgttgag gctagtctgg     1500

gaggagcagg agttttgtct agggaacttg taggaaattc ttggagctga aagtcccaca     1560

aagaaggccc tggcaccaag ggagtcagca aacttcagat tttattctct gggcaggcat     1620

ttcaagtttc cttttgctgt gacatactca tccattagac agcctgatac aggcctgtag     1680

cctcttccgg ccgtgtgtgc tggggaagcc ccaggaaacg cacatgccca cacagggagc     1740

caagtcgtag catttgggcc ttgatctacc ttttctgcat caatacactc ttgagccttt     1800

gaaaaaagaa cgtttcccac taaaaagaaa atgtggattt ttaaaatagg gactcttcct     1860

aggggaaaaa ggggggctgg gagtgataga gggtttaaaa aataaacacc ttcaaactaa     1920

cttcttcgaa cccttttatt cactccctga cgactttgtg ctggggttgg ggtaactgaa     1980

ccgcttattt ctgtttaatt gcattcaggc tggatcttag aagactttta tccttccacc     2040

atctctctca gaggaatgag cggggaggtt ggatttactg gtgactgatt ttctttcatg     2100

ggccaaggaa ctgaaagaga atgtgaagca aggttgtgtc ttgcgcatgg ttaaaaataa     2160

agcattgtcc tgcttcctaa gacttagact ggggttgaca attgttttag caacaagaca     2220

attcaactat ttctcctagg atttttatta ttattatttt ttcacttttc taccaaatgg     2280

gttacatagg aagaatgaac tgaaatctgt ccagagctcc aagtcctttg gaagaaagat     2340

tagatgaacg taaaaatgtt gttgtttgct gtggcagttt acagcatttt tcttgcaaaa     2400

ttagtgcaaa tctgttggaa atagaacaca attcacaaat tggaagtgaa ctaaaatgta     2460

atgacgaaaa gggagtagtg ttttgatttg gaggaggtgt atattcggca gaggttggac     2520

tgagagttgg gtgttattta acataattat ggtaattggg aaacatttat aaacactatt     2580

gggatggtga taaaatacaa aagggcctat agatgttaga aatgggtcag gttactgaaa     2640

tgggattcaa tttgaaaaaa atttttttaa atagaactca ctgaactaga ttctcctctg     2700

agaaccagag aagaccattt catagttgga ttcctggaga catgcgctat ccaccacgta     2760

gccactttcc acatgtggcc atcaaccact taagatgggg ttagtttaaa tcaagatgtg     2820

ctgttataat tggtataagc ataaaatcac actagattct ggagatttaa tatgaataat     2880

aagaatacta tttcagtagt tttggtatat tgtgtgtcaa aaatgataat attttggatg     2940

tattgggtga aataaaatat taacattaaa aaaaaaaa                             2978


