                         SEQUENCE LISTING

<110>  Insusense ApS
 
<120>  Compositions

<130>  RMC00128WO

<160>  27    

<150>  EP18212797.7
<151>  2018.12.14

<170>  PatentIn version 3.5

<210>  1
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPS10p Domain- isoform 1

<400>  1

Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro Gly Glu Asp Glu Glu Cys 
1               5                   10                  15      


Gly Arg Val Arg Asp Phe Val Ala Lys Leu Ala Asn Asn Thr His Gln 
            20                  25                  30          


His Val Phe Asp Asp Leu Arg Gly Ser Val Ser Leu Ser Trp Val Gly 
        35                  40                  45              


Asp Ser Thr Gly Val Ile Leu Val Leu Thr Thr Phe His Val Pro Leu 
    50                  55                  60                  


Val Ile Met Thr Phe Gly Gln Ser Lys Leu Tyr Arg Ser Glu Asp Tyr 
65                  70                  75                  80  


Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile 
                85                  90                  95      


Arg Thr Glu Phe Gly Met Ala Ile Gly Pro Glu Asn Ser Gly Lys Val 
            100                 105                 110         


Val Leu Thr Ala Glu Val Ser Gly Gly Ser Arg Gly Gly Arg Ile Phe 
        115                 120                 125             


Arg Ser Ser Asp Phe Ala Lys Asn Phe Val Gln Thr Asp Leu Pro Phe 
    130                 135                 140                 


His Pro Leu Thr Gln Met Met Tyr Ser Pro Gln Asn Ser Asp Tyr Leu 
145                 150                 155                 160 


Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp Val Ser Lys Asn Phe Gly 
                165                 170                 175     


Gly Lys Trp Glu Glu Ile His Lys Ala Val Cys Leu Ala Lys Trp Gly 
            180                 185                 190         


Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr Ala Asn Gly Ser Cys Lys 
        195                 200                 205             


Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr Ser Asp Leu Gly Lys 
    210                 215                 220                 


Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser Phe Gly Leu Gly Gly 
225                 230                 235                 240 


Arg Phe Leu Phe Ala Ser Val Met Ala Asp Lys Asp Thr Thr Arg Arg 
                245                 250                 255     


Ile His Val Ser Thr Asp Gln Gly Asp Thr Trp Ser Met Ala Gln Leu 
            260                 265                 270         


Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile Leu Ala Ala Asn Asp 
        275                 280                 285             


Asp Met Val Phe Met His Val Asp Glu Pro Gly Asp Thr Gly Phe Gly 
    290                 295                 300                 


Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile Val Tyr Ser Lys Ser Leu 
305                 310                 315                 320 


Asp Arg His Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn 
                325                 330                 335     


Val Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser Val Leu Ser Glu Asp 
            340                 345                 350         


Asn Ser Ile Gln Thr Met Ile Thr Phe Asp Gln Gly Gly Arg Trp Thr 
        355                 360                 365             


His Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp Ala Thr Ala Lys Asn 
    370                 375                 380                 


Lys Asn Glu Cys Ser Leu His Ile His Ala Ser Tyr Ser Ile Ser Gln 
385                 390                 395                 400 


Lys Leu Asn Val Pro Met Ala Pro Leu Ser Glu Pro Asn Ala Val Gly 
                405                 410                 415     


Ile Val Ile Ala His Gly Ser Val Gly Asp Ala Ile Ser Val Met Val 
            420                 425                 430         


Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr Ser Trp Thr Lys Met 
        435                 440                 445             


Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp Ser Gly Gly Ile Ile 
    450                 455                 460                 


Val Ala Ile Glu His Ser Ser Arg Pro Ile Asn Val Ile Lys Phe Ser 
465                 470                 475                 480 


Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr Phe Thr Arg Asp Pro 
                485                 490                 495     


Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly Ala Arg Ser Met Asn 
            500                 505                 510         


Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu Thr Ser Gln Trp Val 
        515                 520                 525             


Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu Arg 
    530                 535                 540 


<210>  2
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPS10p Domain + 10CCa Domain- isoform 1

<400>  2

Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro Gly Glu Asp Glu Glu Cys 
1               5                   10                  15      


Gly Arg Val Arg Asp Phe Val Ala Lys Leu Ala Asn Asn Thr His Gln 
            20                  25                  30          


His Val Phe Asp Asp Leu Arg Gly Ser Val Ser Leu Ser Trp Val Gly 
        35                  40                  45              


Asp Ser Thr Gly Val Ile Leu Val Leu Thr Thr Phe His Val Pro Leu 
    50                  55                  60                  


Val Ile Met Thr Phe Gly Gln Ser Lys Leu Tyr Arg Ser Glu Asp Tyr 
65                  70                  75                  80  


Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile 
                85                  90                  95      


Arg Thr Glu Phe Gly Met Ala Ile Gly Pro Glu Asn Ser Gly Lys Val 
            100                 105                 110         


Val Leu Thr Ala Glu Val Ser Gly Gly Ser Arg Gly Gly Arg Ile Phe 
        115                 120                 125             


Arg Ser Ser Asp Phe Ala Lys Asn Phe Val Gln Thr Asp Leu Pro Phe 
    130                 135                 140                 


His Pro Leu Thr Gln Met Met Tyr Ser Pro Gln Asn Ser Asp Tyr Leu 
145                 150                 155                 160 


Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp Val Ser Lys Asn Phe Gly 
                165                 170                 175     


Gly Lys Trp Glu Glu Ile His Lys Ala Val Cys Leu Ala Lys Trp Gly 
            180                 185                 190         


Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr Ala Asn Gly Ser Cys Lys 
        195                 200                 205             


Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr Ser Asp Leu Gly Lys 
    210                 215                 220                 


Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser Phe Gly Leu Gly Gly 
225                 230                 235                 240 


Arg Phe Leu Phe Ala Ser Val Met Ala Asp Lys Asp Thr Thr Arg Arg 
                245                 250                 255     


Ile His Val Ser Thr Asp Gln Gly Asp Thr Trp Ser Met Ala Gln Leu 
            260                 265                 270         


Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile Leu Ala Ala Asn Asp 
        275                 280                 285             


Asp Met Val Phe Met His Val Asp Glu Pro Gly Asp Thr Gly Phe Gly 
    290                 295                 300                 


Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile Val Tyr Ser Lys Ser Leu 
305                 310                 315                 320 


Asp Arg His Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn 
                325                 330                 335     


Val Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser Val Leu Ser Glu Asp 
            340                 345                 350         


Asn Ser Ile Gln Thr Met Ile Thr Phe Asp Gln Gly Gly Arg Trp Thr 
        355                 360                 365             


His Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp Ala Thr Ala Lys Asn 
    370                 375                 380                 


Lys Asn Glu Cys Ser Leu His Ile His Ala Ser Tyr Ser Ile Ser Gln 
385                 390                 395                 400 


Lys Leu Asn Val Pro Met Ala Pro Leu Ser Glu Pro Asn Ala Val Gly 
                405                 410                 415     


Ile Val Ile Ala His Gly Ser Val Gly Asp Ala Ile Ser Val Met Val 
            420                 425                 430         


Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr Ser Trp Thr Lys Met 
        435                 440                 445             


Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp Ser Gly Gly Ile Ile 
    450                 455                 460                 


Val Ala Ile Glu His Ser Ser Arg Pro Ile Asn Val Ile Lys Phe Ser 
465                 470                 475                 480 


Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr Phe Thr Arg Asp Pro 
                485                 490                 495     


Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly Ala Arg Ser Met Asn 
            500                 505                 510         


Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu Thr Ser Gln Trp Val 
        515                 520                 525             


Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu Arg Asn Cys Glu Glu 
    530                 535                 540                 


Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr Asp Pro Glu Asp Tyr 
545                 550                 555                 560 


Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln Phe Leu Arg Leu Arg 
                565                 570                 575     


Lys Ser Ser Met Cys Gln Asn Gly Arg Asp Tyr Val Val Thr Lys Gln 
            580                 585                 590         


Pro Ser Ile Cys Leu 
        595         


<210>  3
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPS10p Domain + 10CCb Domain- isoform 1

<400>  3

Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro Gly Glu Asp Glu Glu Cys 
1               5                   10                  15      


Gly Arg Val Arg Asp Phe Val Ala Lys Leu Ala Asn Asn Thr His Gln 
            20                  25                  30          


His Val Phe Asp Asp Leu Arg Gly Ser Val Ser Leu Ser Trp Val Gly 
        35                  40                  45              


Asp Ser Thr Gly Val Ile Leu Val Leu Thr Thr Phe His Val Pro Leu 
    50                  55                  60                  


Val Ile Met Thr Phe Gly Gln Ser Lys Leu Tyr Arg Ser Glu Asp Tyr 
65                  70                  75                  80  


Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile 
                85                  90                  95      


Arg Thr Glu Phe Gly Met Ala Ile Gly Pro Glu Asn Ser Gly Lys Val 
            100                 105                 110         


Val Leu Thr Ala Glu Val Ser Gly Gly Ser Arg Gly Gly Arg Ile Phe 
        115                 120                 125             


Arg Ser Ser Asp Phe Ala Lys Asn Phe Val Gln Thr Asp Leu Pro Phe 
    130                 135                 140                 


His Pro Leu Thr Gln Met Met Tyr Ser Pro Gln Asn Ser Asp Tyr Leu 
145                 150                 155                 160 


Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp Val Ser Lys Asn Phe Gly 
                165                 170                 175     


Gly Lys Trp Glu Glu Ile His Lys Ala Val Cys Leu Ala Lys Trp Gly 
            180                 185                 190         


Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr Ala Asn Gly Ser Cys Lys 
        195                 200                 205             


Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr Ser Asp Leu Gly Lys 
    210                 215                 220                 


Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser Phe Gly Leu Gly Gly 
225                 230                 235                 240 


Arg Phe Leu Phe Ala Ser Val Met Ala Asp Lys Asp Thr Thr Arg Arg 
                245                 250                 255     


Ile His Val Ser Thr Asp Gln Gly Asp Thr Trp Ser Met Ala Gln Leu 
            260                 265                 270         


Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile Leu Ala Ala Asn Asp 
        275                 280                 285             


Asp Met Val Phe Met His Val Asp Glu Pro Gly Asp Thr Gly Phe Gly 
    290                 295                 300                 


Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile Val Tyr Ser Lys Ser Leu 
305                 310                 315                 320 


Asp Arg His Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn 
                325                 330                 335     


Val Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser Val Leu Ser Glu Asp 
            340                 345                 350         


Asn Ser Ile Gln Thr Met Ile Thr Phe Asp Gln Gly Gly Arg Trp Thr 
        355                 360                 365             


His Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp Ala Thr Ala Lys Asn 
    370                 375                 380                 


Lys Asn Glu Cys Ser Leu His Ile His Ala Ser Tyr Ser Ile Ser Gln 
385                 390                 395                 400 


Lys Leu Asn Val Pro Met Ala Pro Leu Ser Glu Pro Asn Ala Val Gly 
                405                 410                 415     


Ile Val Ile Ala His Gly Ser Val Gly Asp Ala Ile Ser Val Met Val 
            420                 425                 430         


Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr Ser Trp Thr Lys Met 
        435                 440                 445             


Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp Ser Gly Gly Ile Ile 
    450                 455                 460                 


Val Ala Ile Glu His Ser Ser Arg Pro Ile Asn Val Ile Lys Phe Ser 
465                 470                 475                 480 


Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr Phe Thr Arg Asp Pro 
                485                 490                 495     


Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly Ala Arg Ser Met Asn 
            500                 505                 510         


Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu Thr Ser Gln Trp Val 
        515                 520                 525             


Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu Arg Cys Ser Leu Glu 
    530                 535                 540                 


Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys 
545                 550                 555                 560 


Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu 
                565                 570                 575     


Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro 
            580                 585                 590         


Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp 
        595                 600                 605             


Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln 
    610                 615                 620             


<210>  4
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPS10p Domain + 10CCa Domain + 10CCb Domain- isoform 1

<400>  4

Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro Gly Glu Asp Glu Glu Cys 
1               5                   10                  15      


Gly Arg Val Arg Asp Phe Val Ala Lys Leu Ala Asn Asn Thr His Gln 
            20                  25                  30          


His Val Phe Asp Asp Leu Arg Gly Ser Val Ser Leu Ser Trp Val Gly 
        35                  40                  45              


Asp Ser Thr Gly Val Ile Leu Val Leu Thr Thr Phe His Val Pro Leu 
    50                  55                  60                  


Val Ile Met Thr Phe Gly Gln Ser Lys Leu Tyr Arg Ser Glu Asp Tyr 
65                  70                  75                  80  


Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile 
                85                  90                  95      


Arg Thr Glu Phe Gly Met Ala Ile Gly Pro Glu Asn Ser Gly Lys Val 
            100                 105                 110         


Val Leu Thr Ala Glu Val Ser Gly Gly Ser Arg Gly Gly Arg Ile Phe 
        115                 120                 125             


Arg Ser Ser Asp Phe Ala Lys Asn Phe Val Gln Thr Asp Leu Pro Phe 
    130                 135                 140                 


His Pro Leu Thr Gln Met Met Tyr Ser Pro Gln Asn Ser Asp Tyr Leu 
145                 150                 155                 160 


Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp Val Ser Lys Asn Phe Gly 
                165                 170                 175     


Gly Lys Trp Glu Glu Ile His Lys Ala Val Cys Leu Ala Lys Trp Gly 
            180                 185                 190         


Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr Ala Asn Gly Ser Cys Lys 
        195                 200                 205             


Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr Ser Asp Leu Gly Lys 
    210                 215                 220                 


Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser Phe Gly Leu Gly Gly 
225                 230                 235                 240 


Arg Phe Leu Phe Ala Ser Val Met Ala Asp Lys Asp Thr Thr Arg Arg 
                245                 250                 255     


Ile His Val Ser Thr Asp Gln Gly Asp Thr Trp Ser Met Ala Gln Leu 
            260                 265                 270         


Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile Leu Ala Ala Asn Asp 
        275                 280                 285             


Asp Met Val Phe Met His Val Asp Glu Pro Gly Asp Thr Gly Phe Gly 
    290                 295                 300                 


Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile Val Tyr Ser Lys Ser Leu 
305                 310                 315                 320 


Asp Arg His Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn 
                325                 330                 335     


Val Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser Val Leu Ser Glu Asp 
            340                 345                 350         


Asn Ser Ile Gln Thr Met Ile Thr Phe Asp Gln Gly Gly Arg Trp Thr 
        355                 360                 365             


His Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp Ala Thr Ala Lys Asn 
    370                 375                 380                 


Lys Asn Glu Cys Ser Leu His Ile His Ala Ser Tyr Ser Ile Ser Gln 
385                 390                 395                 400 


Lys Leu Asn Val Pro Met Ala Pro Leu Ser Glu Pro Asn Ala Val Gly 
                405                 410                 415     


Ile Val Ile Ala His Gly Ser Val Gly Asp Ala Ile Ser Val Met Val 
            420                 425                 430         


Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr Ser Trp Thr Lys Met 
        435                 440                 445             


Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp Ser Gly Gly Ile Ile 
    450                 455                 460                 


Val Ala Ile Glu His Ser Ser Arg Pro Ile Asn Val Ile Lys Phe Ser 
465                 470                 475                 480 


Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr Phe Thr Arg Asp Pro 
                485                 490                 495     


Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly Ala Arg Ser Met Asn 
            500                 505                 510         


Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu Thr Ser Gln Trp Val 
        515                 520                 525             


Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu Arg Asn Cys Glu Glu 
    530                 535                 540                 


Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr Asp Pro Glu Asp Tyr 
545                 550                 555                 560 


Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln Phe Leu Arg Leu Arg 
                565                 570                 575     


Lys Ser Ser Met Cys Gln Asn Gly Arg Asp Tyr Val Val Thr Lys Gln 
            580                 585                 590         


Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp Phe Leu Cys Asp Phe Gly 
        595                 600                 605             


Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys Val Glu Gln Pro Glu Leu 
    610                 615                 620                 


Lys Gly His Asp Leu Glu Phe Cys Leu Tyr Gly Arg Glu Glu His Leu 
625                 630                 635                 640 


Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly Asp Lys Cys Gln Gly Gly 
                645                 650                 655     


Val Asn Pro Val Arg Glu Val Lys Asp Leu Lys Lys Lys Cys Thr Ser 
            660                 665                 670         


Asn Phe Leu Ser Pro Glu Lys Gln 
        675                 680 


<210>  5
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10CCa Domain- isoform 1

<400>  5

Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr Asp 
1               5                   10                  15      


Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln Phe 
            20                  25                  30          


Leu Arg Leu Arg Lys Ser Ser Met Cys Gln Asn Gly Arg Asp Tyr Val 
        35                  40                  45              


Val Thr Lys Gln Pro Ser Ile Cys Leu 
    50                  55          


<210>  6
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10CCb Domain- isoform 1

<400>  6

Cys Ser Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu 
1               5                   10                  15      


Asn Asp Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu 
            20                  25                  30          


Glu Phe Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr 
        35                  40                  45              


Arg Lys Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg 
    50                  55                  60                  


Glu Val Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro 
65                  70                  75                  80  


Glu Lys Gln 
            


<210>  7
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10CCa + 10CCb Domain- isoform 1

<400>  7

Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr Asp 
1               5                   10                  15      


Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln Phe 
            20                  25                  30          


Leu Arg Leu Arg Lys Ser Ser Met Cys Gln Asn Gly Arg Asp Tyr Val 
        35                  40                  45              


Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp Phe Leu 
    50                  55                  60                  


Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys Val Glu 
65                  70                  75                  80  


Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr Gly Arg 
                85                  90                  95      


Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly Asp Lys 
            100                 105                 110         


Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu Lys Lys 
        115                 120                 125             


Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln 
    130                 135                 140 


<210>  8
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IST218 after furin site plus HIS tag- isoform 1

<400>  8

Ser Ala Pro Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val 
1               5                   10                  15      


Ala Lys Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg 
            20                  25                  30          


Gly Ser Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu 
        35                  40                  45              


Val Leu Thr Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile 
65                  70                  75                  80  


Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser 
            100                 105                 110         


Gly Gly Ser Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys 
        115                 120                 125             


Asn Phe Val Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met 
    130                 135                 140                 


Tyr Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn 
145                 150                 155                 160 


Gly Leu Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His 
                165                 170                 175     


Lys Ala Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe 
            180                 185                 190         


Thr Thr Tyr Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu 
        195                 200                 205             


Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val 
    210                 215                 220                 


Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val 
225                 230                 235                 240 


Met Ala Asp Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln 
                245                 250                 255     


Gly Asp Thr Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln 
            260                 265                 270         


Phe Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val 
        275                 280                 285             


Asp Glu Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp 
    290                 295                 300                 


Arg Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr 
305                 310                 315                 320 


Thr Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val 
                325                 330                 335     


Tyr Ile Thr Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile 
            340                 345                 350         


Thr Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn 
        355                 360                 365             


Ser Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His 
    370                 375                 380                 


Ile His Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala 
385                 390                 395                 400 


Pro Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser 
                405                 410                 415     


Val Gly Asp Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp 
            420                 425                 430         


Asp Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr 
        435                 440                 445             


Thr Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser 
    450                 455                 460                 


Arg Pro Ile Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp 
465                 470                 475                 480 


Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala 
                485                 490                 495     


Ser Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr 
            500                 505                 510         


Glu Ser Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys 
        515                 520                 525             


Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu 
    530                 535                 540                 


Ala His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly 
545                 550                 555                 560 


Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Met Cys Gln Asn 
                565                 570                 575     


Gly Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser 
            580                 585                 590         


Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp 
        595                 600                 605             


Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe 
    610                 615                 620                 


Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys 
625                 630                 635                 640 


Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val 
                645                 650                 655     


Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys 
            660                 665                 670         


Gln Asn Ser Lys Ser Asn Ser His His His His His His 
        675                 680                 685 


<210>  9
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IST218 after furin site minus HIS tag- isoform 1

<400>  9

Ser Ala Pro Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val 
1               5                   10                  15      


Ala Lys Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg 
            20                  25                  30          


Gly Ser Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu 
        35                  40                  45              


Val Leu Thr Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile 
65                  70                  75                  80  


Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser 
            100                 105                 110         


Gly Gly Ser Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys 
        115                 120                 125             


Asn Phe Val Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met 
    130                 135                 140                 


Tyr Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn 
145                 150                 155                 160 


Gly Leu Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His 
                165                 170                 175     


Lys Ala Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe 
            180                 185                 190         


Thr Thr Tyr Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu 
        195                 200                 205             


Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val 
    210                 215                 220                 


Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val 
225                 230                 235                 240 


Met Ala Asp Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln 
                245                 250                 255     


Gly Asp Thr Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln 
            260                 265                 270         


Phe Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val 
        275                 280                 285             


Asp Glu Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp 
    290                 295                 300                 


Arg Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr 
305                 310                 315                 320 


Thr Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val 
                325                 330                 335     


Tyr Ile Thr Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile 
            340                 345                 350         


Thr Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn 
        355                 360                 365             


Ser Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His 
    370                 375                 380                 


Ile His Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala 
385                 390                 395                 400 


Pro Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser 
                405                 410                 415     


Val Gly Asp Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp 
            420                 425                 430         


Asp Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr 
        435                 440                 445             


Thr Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser 
    450                 455                 460                 


Arg Pro Ile Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp 
465                 470                 475                 480 


Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala 
                485                 490                 495     


Ser Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr 
            500                 505                 510         


Glu Ser Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys 
        515                 520                 525             


Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu 
    530                 535                 540                 


Ala His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly 
545                 550                 555                 560 


Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Met Cys Gln Asn 
                565                 570                 575     


Gly Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser 
            580                 585                 590         


Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp 
        595                 600                 605             


Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe 
    610                 615                 620                 


Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys 
625                 630                 635                 640 


Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val 
                645                 650                 655     


Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys 
            660                 665                 670         


Gln Asn Ser Lys Ser Asn Ser 
        675                 


<210>  10
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SKT1 after furin site plus HIS tag + TEV site-isoform 1

<400>  10

Ser Ala Pro Gly His His His His His His His Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Ser Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys 
            20                  25                  30          


Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser 
        35                  40                  45              


Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu 
    50                  55                  60                  


Thr Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys 
65                  70                  75                  80  


Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp 
                85                  90                  95      


Leu Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly 
            100                 105                 110         


Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly 
        115                 120                 125             


Ser Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe 
    130                 135                 140                 


Val Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser 
145                 150                 155                 160 


Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu 
                165                 170                 175     


Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala 
            180                 185                 190         


Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr 
        195                 200                 205             


Tyr Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp 
    210                 215                 220                 


Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile 
225                 230                 235                 240 


Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala 
                245                 250                 255     


Asp Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp 
            260                 265                 270         


Thr Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr 
        275                 280                 285             


Ser Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu 
    290                 295                 300                 


Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly 
305                 310                 315                 320 


Ile Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly 
                325                 330                 335     


Gly Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile 
            340                 345                 350         


Thr Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe 
        355                 360                 365             


Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu 
    370                 375                 380                 


Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His 
385                 390                 395                 400 


Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu 
                405                 410                 415     


Ser Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly 
            420                 425                 430         


Asp Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly 
        435                 440                 445             


Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile 
    450                 455                 460                 


Leu Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro 
465                 470                 475                 480 


Ile Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr 
                485                 490                 495     


Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu 
            500                 505                 510         


Pro Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser 
        515                 520                 525             


Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile 
    530                 535                 540                 


Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His 
545                 550                 555                 560 


Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys 
                565                 570                 575     


Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Met Cys Gln Asn Gly Arg 
            580                 585                 590         


Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu 
        595                 600                 605             


Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys 
    610                 615                 620                 


Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu 
625                 630                 635                 640 


Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro 
                645                 650                 655     


Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp 
            660                 665                 670         


Leu Lys Lys Lys Cys Thr Ser Asn 
        675                 680 


<210>  11
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SKT1 after furin site minus HIS tag + TEV site- isoform 1

<400>  11

Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu Ala 
1               5                   10                  15      


Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val Ser 
            20                  25                  30          


Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr Thr 
        35                  40                  45              


Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu Tyr 
    50                  55                  60                  


Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu Ile 
65                  70                  75                  80  


Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro Glu 
                85                  90                  95      


Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser Arg 
            100                 105                 110         


Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val Gln 
        115                 120                 125             


Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro Gln 
    130                 135                 140                 


Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp Val 
145                 150                 155                 160 


Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val Cys 
                165                 170                 175     


Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr Ala 
            180                 185                 190         


Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr 
        195                 200                 205             


Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser 
    210                 215                 220                 


Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp Lys 
225                 230                 235                 240 


Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr Trp 
                245                 250                 255     


Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile 
            260                 265                 270         


Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro Gly 
        275                 280                 285             


Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile Val 
    290                 295                 300                 


Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly Glu 
305                 310                 315                 320 


Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser 
                325                 330                 335     


Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp Gln 
            340                 345                 350         


Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp 
        355                 360                 365             


Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala Ser 
    370                 375                 380                 


Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser Glu 
385                 390                 395                 400 


Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp Ala 
                405                 410                 415     


Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr 
            420                 425                 430         


Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp 
        435                 440                 445             


Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile Asn 
    450                 455                 460                 


Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr 
465                 470                 475                 480 


Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly 
                485                 490                 495     


Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu 
            500                 505                 510         


Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu 
        515                 520                 525             


Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr 
    530                 535                 540                 


Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln 
545                 550                 555                 560 


Phe Leu Arg Leu Arg Lys Ser Ser Met Cys Gln Asn Gly Arg Asp Tyr 
                565                 570                 575     


Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp Phe 
            580                 585                 590         


Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys Val 
        595                 600                 605             


Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr Gly 
    610                 615                 620                 


Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly Asp 
625                 630                 635                 640 


Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu Lys 
                645                 650                 655     


Lys Lys Cys Thr Ser Asn 
            660         


<210>  12
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg 
        275                 280                 285             


Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr 
    290                 295                 300                 


Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp 
305                 310                 315                 320 


Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr 
                325                 330                 335     


Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser 
            340                 345                 350         


Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro 
        355                 360                 365             


Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile 
    370                 375                 380                 


Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly 
385                 390                 395                 400 


Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr 
                405                 410                 415     


Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp 
            420                 425                 430         


Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys 
        435                 440                 445             


Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala 
    450                 455                 460                 


Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser 
465                 470                 475                 480 


Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp 
                485                 490                 495     


Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly 
            500                 505                 510         


Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu 
        515                 520                 525             


Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile 
    530                 535                 540                 


Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr 
545                 550                 555                 560 


Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro 
                565                 570                 575     


Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe 
            580                 585                 590         


Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu 
        595                 600                 605             


Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser 
    610                 615                 620                 


Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu 
625                 630                 635                 640 


Gln Phe Leu Arg Leu Arg Lys Ser Ser Met Cys Gln Asn Gly Arg Asp 
                645                 650                 655     


Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp 
            660                 665                 670         


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
        675                 680                 685             


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
    690                 695                 700                 


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
705                 710                 715                 720 


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
                725                 730                 735     


Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser 
            740                 745                 750         


Lys Ser Asn Ser Val Pro Ile Ile Leu Ala Ile Val Gly Leu Met Leu 
        755                 760                 765             


Val Thr Val Val Ala Gly Val Leu Ile Val Lys Lys Tyr Val Cys Gly 
    770                 775                 780                 


Gly Arg Phe Leu Val His Arg Tyr Ser Val Leu Gln Gln His Ala Glu 
785                 790                 795                 800 


Ala Asn Gly Val Asp Gly Val Asp Ala Leu Asp Thr Ala Ser His Thr 
                805                 810                 815     


Asn Lys Ser Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
            820                 825                 830     


<210>  13
<211>  830
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Thr Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr 
        275                 280                 285             


Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser 
    290                 295                 300                 


Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp Lys 
305                 310                 315                 320 


Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr Trp 
                325                 330                 335     


Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile 
            340                 345                 350         


Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro Gly 
        355                 360                 365             


Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile Val 
    370                 375                 380                 


Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly Glu 
385                 390                 395                 400 


Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser 
                405                 410                 415     


Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp Gln 
            420                 425                 430         


Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp 
        435                 440                 445             


Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala Ser 
    450                 455                 460                 


Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser Glu 
465                 470                 475                 480 


Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp Ala 
                485                 490                 495     


Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr 
            500                 505                 510         


Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp 
        515                 520                 525             


Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile Asn 
    530                 535                 540                 


Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr 
545                 550                 555                 560 


Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly 
                565                 570                 575     


Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu 
            580                 585                 590         


Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu 
        595                 600                 605             


Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr 
    610                 615                 620                 


Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln 
625                 630                 635                 640 


Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp Tyr 
                645                 650                 655     


Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp Phe 
            660                 665                 670         


Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys Val 
        675                 680                 685             


Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr Gly 
    690                 695                 700                 


Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly Asp 
705                 710                 715                 720 


Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu Lys 
                725                 730                 735     


Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser Lys 
            740                 745                 750         


Ser Asn Ser Val Pro Ile Ile Leu Ala Ile Val Gly Leu Met Leu Val 
        755                 760                 765             


Thr Val Val Ala Gly Val Leu Ile Val Lys Lys Tyr Val Cys Gly Gly 
    770                 775                 780                 


Arg Phe Leu Val His Arg Tyr Ser Val Leu Gln Gln His Ala Glu Ala 
785                 790                 795                 800 


Asn Gly Val Asp Gly Val Asp Ala Leu Asp Thr Ala Ser His Thr Asn 
                805                 810                 815     


Lys Ser Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
            820                 825                 830 


<210>  14
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPS10p Domain- isoform 2

<400>  14

Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro Gly Glu Asp Glu Glu Cys 
1               5                   10                  15      


Gly Arg Val Arg Asp Phe Val Ala Lys Leu Ala Asn Asn Thr His Gln 
            20                  25                  30          


His Val Phe Asp Asp Leu Arg Gly Ser Val Ser Leu Ser Trp Val Gly 
        35                  40                  45              


Asp Ser Thr Gly Val Ile Leu Val Leu Thr Thr Phe His Val Pro Leu 
    50                  55                  60                  


Val Ile Met Thr Phe Gly Gln Ser Lys Leu Tyr Arg Ser Glu Asp Tyr 
65                  70                  75                  80  


Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile 
                85                  90                  95      


Arg Thr Glu Phe Gly Met Ala Ile Gly Pro Glu Asn Ser Gly Lys Val 
            100                 105                 110         


Val Leu Thr Ala Glu Val Ser Gly Gly Ser Arg Gly Gly Arg Ile Phe 
        115                 120                 125             


Arg Ser Ser Asp Phe Ala Lys Asn Phe Val Gln Thr Asp Leu Pro Phe 
    130                 135                 140                 


His Pro Leu Thr Gln Met Met Tyr Ser Pro Gln Asn Ser Asp Tyr Leu 
145                 150                 155                 160 


Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp Val Ser Lys Asn Phe Gly 
                165                 170                 175     


Gly Lys Trp Glu Glu Ile His Lys Ala Val Cys Leu Ala Lys Trp Gly 
            180                 185                 190         


Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr Ala Asn Gly Ser Cys Thr 
        195                 200                 205             


Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser 
    210                 215                 220                 


Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg 
225                 230                 235                 240 


Phe Leu Phe Ala Ser Val Met Ala Asp Lys Asp Thr Thr Arg Arg Ile 
                245                 250                 255     


His Val Ser Thr Asp Gln Gly Asp Thr Trp Ser Met Ala Gln Leu Pro 
            260                 265                 270         


Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile Leu Ala Ala Asn Asp Asp 
        275                 280                 285             


Met Val Phe Met His Val Asp Glu Pro Gly Asp Thr Gly Phe Gly Thr 
    290                 295                 300                 


Ile Phe Thr Ser Asp Asp Arg Gly Ile Val Tyr Ser Lys Ser Leu Asp 
305                 310                 315                 320 


Arg His Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn Val 
                325                 330                 335     


Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser Val Leu Ser Glu Asp Asn 
            340                 345                 350         


Ser Ile Gln Thr Met Ile Thr Phe Asp Gln Gly Gly Arg Trp Thr His 
        355                 360                 365             


Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp Ala Thr Ala Lys Asn Lys 
    370                 375                 380                 


Asn Glu Cys Ser Leu His Ile His Ala Ser Tyr Ser Ile Ser Gln Lys 
385                 390                 395                 400 


Leu Asn Val Pro Met Ala Pro Leu Ser Glu Pro Asn Ala Val Gly Ile 
                405                 410                 415     


Val Ile Ala His Gly Ser Val Gly Asp Ala Ile Ser Val Met Val Pro 
            420                 425                 430         


Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr Ser Trp Thr Lys Met Leu 
        435                 440                 445             


Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp Ser Gly Gly Ile Ile Val 
    450                 455                 460                 


Ala Ile Glu His Ser Ser Arg Pro Ile Asn Val Ile Lys Phe Ser Thr 
465                 470                 475                 480 


Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile 
                485                 490                 495     


Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly Ala Arg Ser Met Asn Ile 
            500                 505                 510         


Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu Thr Ser Gln Trp Val Ser 
        515                 520                 525             


Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu Arg 
    530                 535                 


<210>  15
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPS10p Domain + 10CCa Domain- isoform 2

<400>  15

Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro Gly Glu Asp Glu Glu Cys 
1               5                   10                  15      


Gly Arg Val Arg Asp Phe Val Ala Lys Leu Ala Asn Asn Thr His Gln 
            20                  25                  30          


His Val Phe Asp Asp Leu Arg Gly Ser Val Ser Leu Ser Trp Val Gly 
        35                  40                  45              


Asp Ser Thr Gly Val Ile Leu Val Leu Thr Thr Phe His Val Pro Leu 
    50                  55                  60                  


Val Ile Met Thr Phe Gly Gln Ser Lys Leu Tyr Arg Ser Glu Asp Tyr 
65                  70                  75                  80  


Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile 
                85                  90                  95      


Arg Thr Glu Phe Gly Met Ala Ile Gly Pro Glu Asn Ser Gly Lys Val 
            100                 105                 110         


Val Leu Thr Ala Glu Val Ser Gly Gly Ser Arg Gly Gly Arg Ile Phe 
        115                 120                 125             


Arg Ser Ser Asp Phe Ala Lys Asn Phe Val Gln Thr Asp Leu Pro Phe 
    130                 135                 140                 


His Pro Leu Thr Gln Met Met Tyr Ser Pro Gln Asn Ser Asp Tyr Leu 
145                 150                 155                 160 


Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp Val Ser Lys Asn Phe Gly 
                165                 170                 175     


Gly Lys Trp Glu Glu Ile His Lys Ala Val Cys Leu Ala Lys Trp Gly 
            180                 185                 190         


Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr Ala Asn Gly Ser Cys Thr 
        195                 200                 205             


Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser 
    210                 215                 220                 


Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg 
225                 230                 235                 240 


Phe Leu Phe Ala Ser Val Met Ala Asp Lys Asp Thr Thr Arg Arg Ile 
                245                 250                 255     


His Val Ser Thr Asp Gln Gly Asp Thr Trp Ser Met Ala Gln Leu Pro 
            260                 265                 270         


Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile Leu Ala Ala Asn Asp Asp 
        275                 280                 285             


Met Val Phe Met His Val Asp Glu Pro Gly Asp Thr Gly Phe Gly Thr 
    290                 295                 300                 


Ile Phe Thr Ser Asp Asp Arg Gly Ile Val Tyr Ser Lys Ser Leu Asp 
305                 310                 315                 320 


Arg His Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn Val 
                325                 330                 335     


Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser Val Leu Ser Glu Asp Asn 
            340                 345                 350         


Ser Ile Gln Thr Met Ile Thr Phe Asp Gln Gly Gly Arg Trp Thr His 
        355                 360                 365             


Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp Ala Thr Ala Lys Asn Lys 
    370                 375                 380                 


Asn Glu Cys Ser Leu His Ile His Ala Ser Tyr Ser Ile Ser Gln Lys 
385                 390                 395                 400 


Leu Asn Val Pro Met Ala Pro Leu Ser Glu Pro Asn Ala Val Gly Ile 
                405                 410                 415     


Val Ile Ala His Gly Ser Val Gly Asp Ala Ile Ser Val Met Val Pro 
            420                 425                 430         


Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr Ser Trp Thr Lys Met Leu 
        435                 440                 445             


Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp Ser Gly Gly Ile Ile Val 
    450                 455                 460                 


Ala Ile Glu His Ser Ser Arg Pro Ile Asn Val Ile Lys Phe Ser Thr 
465                 470                 475                 480 


Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile 
                485                 490                 495     


Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly Ala Arg Ser Met Asn Ile 
            500                 505                 510         


Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu Thr Ser Gln Trp Val Ser 
        515                 520                 525             


Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys 
    530                 535                 540                 


Asp Tyr Thr Ile Trp Leu Ala His Ser Thr Asp Pro Glu Asp Tyr Glu 
545                 550                 555                 560 


Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys 
                565                 570                 575     


Ser Ser Val Cys Gln Asn Gly Arg Asp Tyr Val Val Thr Lys Gln Pro 
            580                 585                 590         


Ser Ile Cys Leu 
        595     


<210>  16
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPS10p Domain + 10CCb Domain- isoform 2

<400>  16

Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro Gly Glu Asp Glu Glu Cys 
1               5                   10                  15      


Gly Arg Val Arg Asp Phe Val Ala Lys Leu Ala Asn Asn Thr His Gln 
            20                  25                  30          


His Val Phe Asp Asp Leu Arg Gly Ser Val Ser Leu Ser Trp Val Gly 
        35                  40                  45              


Asp Ser Thr Gly Val Ile Leu Val Leu Thr Thr Phe His Val Pro Leu 
    50                  55                  60                  


Val Ile Met Thr Phe Gly Gln Ser Lys Leu Tyr Arg Ser Glu Asp Tyr 
65                  70                  75                  80  


Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile 
                85                  90                  95      


Arg Thr Glu Phe Gly Met Ala Ile Gly Pro Glu Asn Ser Gly Lys Val 
            100                 105                 110         


Val Leu Thr Ala Glu Val Ser Gly Gly Ser Arg Gly Gly Arg Ile Phe 
        115                 120                 125             


Arg Ser Ser Asp Phe Ala Lys Asn Phe Val Gln Thr Asp Leu Pro Phe 
    130                 135                 140                 


His Pro Leu Thr Gln Met Met Tyr Ser Pro Gln Asn Ser Asp Tyr Leu 
145                 150                 155                 160 


Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp Val Ser Lys Asn Phe Gly 
                165                 170                 175     


Gly Lys Trp Glu Glu Ile His Lys Ala Val Cys Leu Ala Lys Trp Gly 
            180                 185                 190         


Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr Ala Asn Gly Ser Cys Thr 
        195                 200                 205             


Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser 
    210                 215                 220                 


Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg 
225                 230                 235                 240 


Phe Leu Phe Ala Ser Val Met Ala Asp Lys Asp Thr Thr Arg Arg Ile 
                245                 250                 255     


His Val Ser Thr Asp Gln Gly Asp Thr Trp Ser Met Ala Gln Leu Pro 
            260                 265                 270         


Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile Leu Ala Ala Asn Asp Asp 
        275                 280                 285             


Met Val Phe Met His Val Asp Glu Pro Gly Asp Thr Gly Phe Gly Thr 
    290                 295                 300                 


Ile Phe Thr Ser Asp Asp Arg Gly Ile Val Tyr Ser Lys Ser Leu Asp 
305                 310                 315                 320 


Arg His Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn Val 
                325                 330                 335     


Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser Val Leu Ser Glu Asp Asn 
            340                 345                 350         


Ser Ile Gln Thr Met Ile Thr Phe Asp Gln Gly Gly Arg Trp Thr His 
        355                 360                 365             


Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp Ala Thr Ala Lys Asn Lys 
    370                 375                 380                 


Asn Glu Cys Ser Leu His Ile His Ala Ser Tyr Ser Ile Ser Gln Lys 
385                 390                 395                 400 


Leu Asn Val Pro Met Ala Pro Leu Ser Glu Pro Asn Ala Val Gly Ile 
                405                 410                 415     


Val Ile Ala His Gly Ser Val Gly Asp Ala Ile Ser Val Met Val Pro 
            420                 425                 430         


Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr Ser Trp Thr Lys Met Leu 
        435                 440                 445             


Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp Ser Gly Gly Ile Ile Val 
    450                 455                 460                 


Ala Ile Glu His Ser Ser Arg Pro Ile Asn Val Ile Lys Phe Ser Thr 
465                 470                 475                 480 


Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile 
                485                 490                 495     


Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly Ala Arg Ser Met Asn Ile 
            500                 505                 510         


Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu Thr Ser Gln Trp Val Ser 
        515                 520                 525             


Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu Arg Cys Ser Leu Glu Asp 
    530                 535                 540                 


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
545                 550                 555                 560 


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
                565                 570                 575     


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
            580                 585                 590         


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
        595                 600                 605             


Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln 
    610                 615                 620         


<210>  17
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPS10p Domain + 10CCa Domain + 10CCb Domain- isoform 2

<400>  17

Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro Gly Glu Asp Glu Glu Cys 
1               5                   10                  15      


Gly Arg Val Arg Asp Phe Val Ala Lys Leu Ala Asn Asn Thr His Gln 
            20                  25                  30          


His Val Phe Asp Asp Leu Arg Gly Ser Val Ser Leu Ser Trp Val Gly 
        35                  40                  45              


Asp Ser Thr Gly Val Ile Leu Val Leu Thr Thr Phe His Val Pro Leu 
    50                  55                  60                  


Val Ile Met Thr Phe Gly Gln Ser Lys Leu Tyr Arg Ser Glu Asp Tyr 
65                  70                  75                  80  


Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile 
                85                  90                  95      


Arg Thr Glu Phe Gly Met Ala Ile Gly Pro Glu Asn Ser Gly Lys Val 
            100                 105                 110         


Val Leu Thr Ala Glu Val Ser Gly Gly Ser Arg Gly Gly Arg Ile Phe 
        115                 120                 125             


Arg Ser Ser Asp Phe Ala Lys Asn Phe Val Gln Thr Asp Leu Pro Phe 
    130                 135                 140                 


His Pro Leu Thr Gln Met Met Tyr Ser Pro Gln Asn Ser Asp Tyr Leu 
145                 150                 155                 160 


Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp Val Ser Lys Asn Phe Gly 
                165                 170                 175     


Gly Lys Trp Glu Glu Ile His Lys Ala Val Cys Leu Ala Lys Trp Gly 
            180                 185                 190         


Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr Ala Asn Gly Ser Cys Thr 
        195                 200                 205             


Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser 
    210                 215                 220                 


Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg 
225                 230                 235                 240 


Phe Leu Phe Ala Ser Val Met Ala Asp Lys Asp Thr Thr Arg Arg Ile 
                245                 250                 255     


His Val Ser Thr Asp Gln Gly Asp Thr Trp Ser Met Ala Gln Leu Pro 
            260                 265                 270         


Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile Leu Ala Ala Asn Asp Asp 
        275                 280                 285             


Met Val Phe Met His Val Asp Glu Pro Gly Asp Thr Gly Phe Gly Thr 
    290                 295                 300                 


Ile Phe Thr Ser Asp Asp Arg Gly Ile Val Tyr Ser Lys Ser Leu Asp 
305                 310                 315                 320 


Arg His Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn Val 
                325                 330                 335     


Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser Val Leu Ser Glu Asp Asn 
            340                 345                 350         


Ser Ile Gln Thr Met Ile Thr Phe Asp Gln Gly Gly Arg Trp Thr His 
        355                 360                 365             


Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp Ala Thr Ala Lys Asn Lys 
    370                 375                 380                 


Asn Glu Cys Ser Leu His Ile His Ala Ser Tyr Ser Ile Ser Gln Lys 
385                 390                 395                 400 


Leu Asn Val Pro Met Ala Pro Leu Ser Glu Pro Asn Ala Val Gly Ile 
                405                 410                 415     


Val Ile Ala His Gly Ser Val Gly Asp Ala Ile Ser Val Met Val Pro 
            420                 425                 430         


Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr Ser Trp Thr Lys Met Leu 
        435                 440                 445             


Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp Ser Gly Gly Ile Ile Val 
    450                 455                 460                 


Ala Ile Glu His Ser Ser Arg Pro Ile Asn Val Ile Lys Phe Ser Thr 
465                 470                 475                 480 


Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile 
                485                 490                 495     


Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly Ala Arg Ser Met Asn Ile 
            500                 505                 510         


Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu Thr Ser Gln Trp Val Ser 
        515                 520                 525             


Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys 
    530                 535                 540                 


Asp Tyr Thr Ile Trp Leu Ala His Ser Thr Asp Pro Glu Asp Tyr Glu 
545                 550                 555                 560 


Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys 
                565                 570                 575     


Ser Ser Val Cys Gln Asn Gly Arg Asp Tyr Val Val Thr Lys Gln Pro 
            580                 585                 590         


Ser Ile Cys Leu Cys Ser Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr 
        595                 600                 605             


Tyr Arg Pro Glu Asn Asp Ser Lys Cys Val Glu Gln Pro Glu Leu Lys 
    610                 615                 620                 


Gly His Asp Leu Glu Phe Cys Leu Tyr Gly Arg Glu Glu His Leu Thr 
625                 630                 635                 640 


Thr Asn Gly Tyr Arg Lys Ile Pro Gly Asp Lys Cys Gln Gly Gly Val 
                645                 650                 655     


Asn Pro Val Arg Glu Val Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn 
            660                 665                 670         


Phe Leu Ser Pro Glu Lys Gln 
        675                 


<210>  18
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10CCa Domain- isoform 2

<400>  18

Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr Asp 
1               5                   10                  15      


Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln Phe 
            20                  25                  30          


Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp Tyr Val 
        35                  40                  45              


Val Thr Lys Gln Pro Ser Ile Cys Leu 
    50                  55          


<210>  19
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10CCa Domain + 10CCb Domain- isoform 2

<400>  19

Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr Asp 
1               5                   10                  15      


Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln Phe 
            20                  25                  30          


Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp Tyr Val 
        35                  40                  45              


Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp Phe Leu 
    50                  55                  60                  


Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys Val Glu 
65                  70                  75                  80  


Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr Gly Arg 
                85                  90                  95      


Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly Asp Lys 
            100                 105                 110         


Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu Lys Lys 
        115                 120                 125             


Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln 
    130                 135                 140 


<210>  20
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IST218 after furin site plus HIS tag- isoform 2

<400>  20

Ser Ala Pro Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val 
1               5                   10                  15      


Ala Lys Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg 
            20                  25                  30          


Gly Ser Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu 
        35                  40                  45              


Val Leu Thr Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile 
65                  70                  75                  80  


Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser 
            100                 105                 110         


Gly Gly Ser Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys 
        115                 120                 125             


Asn Phe Val Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met 
    130                 135                 140                 


Tyr Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn 
145                 150                 155                 160 


Gly Leu Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His 
                165                 170                 175     


Lys Ala Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe 
            180                 185                 190         


Thr Thr Tyr Ala Asn Gly Ser Cys Thr Asp Leu Gly Ala Leu Glu Leu 
        195                 200                 205             


Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys 
    210                 215                 220                 


Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met 
225                 230                 235                 240 


Ala Asp Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly 
                245                 250                 255     


Asp Thr Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe 
            260                 265                 270         


Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp 
        275                 280                 285             


Glu Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg 
    290                 295                 300                 


Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr 
305                 310                 315                 320 


Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr 
                325                 330                 335     


Ile Thr Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr 
            340                 345                 350         


Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser 
        355                 360                 365             


Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile 
    370                 375                 380                 


His Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro 
385                 390                 395                 400 


Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val 
                405                 410                 415     


Gly Asp Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp 
            420                 425                 430         


Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr 
        435                 440                 445             


Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg 
    450                 455                 460                 


Pro Ile Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser 
                485                 490                 495     


Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu 
            500                 505                 510         


Ser Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp 
        515                 520                 525             


Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala 
    530                 535                 540                 


His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr 
545                 550                 555                 560 


Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly 
                565                 570                 575     


Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu 
            580                 585                 590         


Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser 
        595                 600                 605             


Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys 
    610                 615                 620                 


Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile 
625                 630                 635                 640 


Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys 
                645                 650                 655     


Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln 
            660                 665                 670         


Asn Ser Lys Ser Asn Ser His His His His His His 
        675                 680                 


<210>  21
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IST218 after furin site minus HIS tag- isoform 2

<400>  21

Ser Ala Pro Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val 
1               5                   10                  15      


Ala Lys Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg 
            20                  25                  30          


Gly Ser Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu 
        35                  40                  45              


Val Leu Thr Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln 
    50                  55                  60                  


Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile 
65                  70                  75                  80  


Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala 
                85                  90                  95      


Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser 
            100                 105                 110         


Gly Gly Ser Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys 
        115                 120                 125             


Asn Phe Val Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met 
    130                 135                 140                 


Tyr Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn 
145                 150                 155                 160 


Gly Leu Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His 
                165                 170                 175     


Lys Ala Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe 
            180                 185                 190         


Thr Thr Tyr Ala Asn Gly Ser Cys Thr Asp Leu Gly Ala Leu Glu Leu 
        195                 200                 205             


Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys 
    210                 215                 220                 


Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met 
225                 230                 235                 240 


Ala Asp Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly 
                245                 250                 255     


Asp Thr Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe 
            260                 265                 270         


Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp 
        275                 280                 285             


Glu Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg 
    290                 295                 300                 


Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr 
305                 310                 315                 320 


Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr 
                325                 330                 335     


Ile Thr Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr 
            340                 345                 350         


Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser 
        355                 360                 365             


Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile 
    370                 375                 380                 


His Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro 
385                 390                 395                 400 


Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val 
                405                 410                 415     


Gly Asp Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp 
            420                 425                 430         


Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr 
        435                 440                 445             


Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg 
    450                 455                 460                 


Pro Ile Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln 
465                 470                 475                 480 


Thr Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser 
                485                 490                 495     


Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu 
            500                 505                 510         


Ser Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp 
        515                 520                 525             


Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala 
    530                 535                 540                 


His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr 
545                 550                 555                 560 


Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly 
                565                 570                 575     


Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu 
            580                 585                 590         


Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser 
        595                 600                 605             


Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys 
    610                 615                 620                 


Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile 
625                 630                 635                 640 


Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys 
                645                 650                 655     


Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln 
            660                 665                 670         


Asn Ser Lys Ser Asn Ser 
        675             


<210>  22
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SKT1 after furin site plus HIS tag + TEV site- isoform 2

<400>  22

Ser Ala Pro Gly His His His His His His His Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Ser Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys 
            20                  25                  30          


Leu Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser 
        35                  40                  45              


Val Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu 
    50                  55                  60                  


Thr Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys 
65                  70                  75                  80  


Leu Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp 
                85                  90                  95      


Leu Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly 
            100                 105                 110         


Pro Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly 
        115                 120                 125             


Ser Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe 
    130                 135                 140                 


Val Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser 
145                 150                 155                 160 


Pro Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu 
                165                 170                 175     


Trp Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala 
            180                 185                 190         


Val Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr 
        195                 200                 205             


Tyr Ala Asn Gly Ser Cys Thr Asp Leu Gly Ala Leu Glu Leu Trp Arg 
    210                 215                 220                 


Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr 
225                 230                 235                 240 


Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp 
                245                 250                 255     


Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr 
            260                 265                 270         


Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser 
        275                 280                 285             


Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro 
    290                 295                 300                 


Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile 
305                 310                 315                 320 


Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly 
                325                 330                 335     


Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr 
            340                 345                 350         


Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp 
        355                 360                 365             


Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys 
    370                 375                 380                 


Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala 
385                 390                 395                 400 


Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser 
                405                 410                 415     


Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp 
            420                 425                 430         


Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly 
        435                 440                 445             


Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu 
    450                 455                 460                 


Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile 
465                 470                 475                 480 


Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr 
                485                 490                 495     


Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro 
            500                 505                 510         


Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe 
        515                 520                 525             


Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu 
    530                 535                 540                 


Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser 
545                 550                 555                 560 


Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu 
                565                 570                 575     


Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp 
            580                 585                 590         


Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp 
        595                 600                 605             


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
    610                 615                 620                 


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
625                 630                 635                 640 


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
                645                 650                 655     


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
            660                 665                 670         


Lys Lys Lys Cys Thr Ser Asn 
        675                 


<210>  23
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SKT1 after furin site minus HIS tag + TEV site- isoform 2

<400>  23

Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu Ala 
1               5                   10                  15      


Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val Ser 
            20                  25                  30          


Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr Thr 
        35                  40                  45              


Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu Tyr 
    50                  55                  60                  


Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu Ile 
65                  70                  75                  80  


Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro Glu 
                85                  90                  95      


Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser Arg 
            100                 105                 110         


Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val Gln 
        115                 120                 125             


Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro Gln 
    130                 135                 140                 


Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp Val 
145                 150                 155                 160 


Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val Cys 
                165                 170                 175     


Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr Ala 
            180                 185                 190         


Asn Gly Ser Cys Thr Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr Ser 
        195                 200                 205             


Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser Phe 
    210                 215                 220                 


Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp Lys Asp 
225                 230                 235                 240 


Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr Trp Ser 
                245                 250                 255     


Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile Leu 
            260                 265                 270         


Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro Gly Asp 
        275                 280                 285             


Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile Val Tyr 
    290                 295                 300                 


Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly Glu Thr 
305                 310                 315                 320 


Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser Val 
                325                 330                 335     


Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp Gln Gly 
            340                 345                 350         


Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp Ala 
        355                 360                 365             


Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala Ser Tyr 
    370                 375                 380                 


Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser Glu Pro 
385                 390                 395                 400 


Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp Ala Ile 
                405                 410                 415     


Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr Ser 
            420                 425                 430         


Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp Ser 
        435                 440                 445             


Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile Asn Val 
    450                 455                 460                 


Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr Phe 
465                 470                 475                 480 


Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly Ala 
                485                 490                 495     


Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu Thr 
            500                 505                 510         


Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu Arg 
        515                 520                 525             


Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr Asp 
    530                 535                 540                 


Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln Phe 
545                 550                 555                 560 


Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp Tyr Val 
                565                 570                 575     


Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp Phe Leu 
            580                 585                 590         


Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys Val Glu 
        595                 600                 605             


Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr Gly Arg 
    610                 615                 620                 


Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly Asp Lys 
625                 630                 635                 640 


Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu Lys Lys 
                645                 650                 655     


Lys Cys Thr Ser Asn 
            660     


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV cleavage site option 1

<400>  24

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV cleavage site option 2

<400>  25

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C terminal HIS tag

<400>  26

His His His His His His 
1               5       


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N terminal HIS tag

<400>  27

His His His His His His His 
1               5           


