               SEQUENCE LISTING

<110> Sanofi

<120> Insulin analogs having reduced insulin receptor binding affinity

<130> DE2018/059
 
<150> EP 18 306 657.0
<151> 2018-12-11

<150> EP 18 306 658.8
<151> 2018-12-11

<150> EP 18 306 659.6
<151> 2018-12-11

<160> 97

<170> BiSSAP 1.3.6

<210> 1
<211> 21
<212> PRT
<213> Homo sapiens


<220> 
<223> Chain A

<400> 1
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 2
<211> 30
<212> PRT
<213> Homo sapiens


<220> 
<223> Chain B

<400> 2
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  

<210> 3
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 3
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 4
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 4
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  

<210> 5
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 5
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 6
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 6
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Leu 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  

<210> 7
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 7
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 8
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 8
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Trp 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  

<210> 9
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 9
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 10
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 10
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  

<210> 11
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 11
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 12
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 12
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  

<210> 13
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 13
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 14
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 14
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ala Tyr Thr Pro Lys Thr 
            20                  25                  30  

<210> 15
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 15
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 16
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 16
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ala Tyr Thr Pro Lys 
            20                  25                  

<210> 17
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 17
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 18
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 18
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Glu Tyr Thr Pro Lys 
            20                  25                  

<210> 19
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 19
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 20
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 20
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 
            20                  25                  

<210> 21
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 21
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 22
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 22
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Leu Tyr Thr Pro Lys 
            20                  25                  

<210> 23
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 23
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 24
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 24
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 25
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 25
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 26
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 26
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 
            20                  25                  

<210> 27
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 27
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 28
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 28
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Trp 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 
            20                  25                  

<210> 29
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 29
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 30
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 30
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Trp 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Trp Tyr Thr Pro Lys 
            20                  25                  

<210> 31
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 31
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 32
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 32
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  

<210> 33
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 33
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 34
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 34
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Trp 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  

<210> 35
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 35
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 36
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 36
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  

<210> 37
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 37
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 38
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 38
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  

<210> 39
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 39
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 40
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 40
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  

<210> 41
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 41
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 42
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 42
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 
            20                  25                  

<210> 43
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 43
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 44
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 44
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 
            20                  25                  

<210> 45
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 45
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 46
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 46
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Trp Tyr Thr Pro Lys 
            20                  25                  

<210> 47
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 47
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 48
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 48
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 49
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 49
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 50
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 50
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 51
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 51
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 52
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 52
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Glu 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 
            20                  25                  

<210> 53
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 53
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 54
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 54
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ala Tyr Thr Pro Lys 
            20                  25                  

<210> 55
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 55
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 56
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 56
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 
            20                  25                  

<210> 57
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 57
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 58
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 58
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 
            20                  25                  

<210> 59
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 59
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 60
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 60
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 
            20                  25                  

<210> 61
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 61
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 62
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 62
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Trp Tyr Thr Pro Lys 
            20                  25                  

<210> 63
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 63
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 64
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 64
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 65
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 65
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 66
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 66
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 67
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 67
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 68
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 68
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Leu 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ala Tyr Thr Pro Lys 
            20                  25                  

<210> 69
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 69
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 70
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 70
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 
            20                  25                  

<210> 71
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 71
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 72
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 72
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Trp Tyr Thr Pro Lys 
            20                  25                  

<210> 73
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 73
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 74
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 74
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Trp Tyr Thr Pro Lys 
            20                  25                  

<210> 75
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 75
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 76
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 76
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 77
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 77
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 78
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 78
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 79
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain A

<400> 79
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Gly 
            20      

<210> 80
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 80
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 81
<211> 21
<212> PRT
<213> Bos


<220> 
<223> Chain A

<400> 81
Gly Ile Val Glu Gln Cys Cys Ala Ser Val Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 82
<211> 30
<212> PRT
<213> Bos


<220> 
<223> Chain B

<400> 82
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala 
            20                  25                  30  

<210> 83
<211> 21
<212> PRT
<213> Sus


<220> 
<223> Chain A

<400> 83
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      
Glu Asn Tyr Cys Asn 
            20      

<210> 84
<211> 30
<212> PRT
<213> Sus


<220> 
<223> Chain B

<400> 84
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala 
            20                  25                  30  

<210> 85
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 85
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Leu Tyr Thr Pro Lys 
            20                  25                  

<210> 86
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 86
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 87
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 87
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 
            20                  25                  

<210> 88
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 88
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 89
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 89
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 90
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 90
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 
            20                  25                  

<210> 91
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 91
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 
            20                  25                  

<210> 92
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 92
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 93
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 93
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ile 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 94
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 94
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Ile Tyr Thr Pro Lys 
            20                  25                  

<210> 95
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 95
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 96
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 96
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

<210> 97
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chain B

<400> 97
Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Val 
1               5                   10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Val Tyr Thr Pro Lys 
            20                  25                  

