                         б

<110>  йѧԺȽоԺ
 
<120>  H7N9ȫԴ¡3F12ƷӦ

<130>  PCT1901137

<160>  37     

<170>  PatentIn version 3.5

<210>  1
<211>  378
<212>  DNA
<213>  ˹

<400>  1
caagtgcagc tggtggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata tattttcaac agttatgata tcaactgggt gcgacaggcc      120

actggccaag ggcttgagtg gatgggatgg atgactcccg atagtggaga taacggcttt      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataac cacagcctac      240

atggagctga gcagcctgac ttctgaggac acggccgtgt attactgtgc gaacgggacg      300

gcggattgta gcagcggagg gagctgctac acgtggttcg acccgtgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210>  2
<211>  126
<212>  PRT
<213>  ˹

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Asn Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Thr Pro Asp Ser Gly Asp Asn Gly Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Gly Thr Ala Asp Cys Ser Ser Gly Gly Ser Cys Tyr Thr Trp 
            100                 105                 110         


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  3
<211>  330
<212>  DNA
<213>  ˹

<400>  3
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagagc gctgagaagc tactacgcaa gctggtacca gcagaagcca      120

ggacaggccc ctgtacttgt catctatggt aaaaccaacc ggccctcagg gatcccagac      180

cgattctctg gctccagctc aggaaacaca gcttccttga ccatcactgg ggctcaggcg      240

gaagatgagg ctgactatta ctgtacctcc cgggacaaca gtggttacca tctggtgttc      300

ggcggaggga ccaagctgac cgtcctagta                                       330


<210>  4
<211>  110
<212>  PRT
<213>  ˹

<400>  4

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Arg Ala Leu Arg Ser Tyr Tyr 
            20                  25                  30          


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        35                  40                  45              


Tyr Gly Lys Thr Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Arg Asp Asn Ser Gly Tyr 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Val 
            100                 105                 110 


<210>  5
<211>  1419
<212>  DNA
<213>  ˹

<400>  5
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggcca agtgcagctg       60

gtggagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc ctgcaaggct      120

tctggatata ttttcaacag ttatgatatc aactgggtgc gacaggccac tggccaaggg      180

cttgagtgga tgggatggat gactcccgat agtggagata acggctttgc acagaagttc      240

cagggcagag tcaccatgac caggaacacc tccataacca cagcctacat ggagctgagc      300

agcctgactt ctgaggacac ggccgtgtat tactgtgcga acgggacggc ggattgtagc      360

agcggaggga gctgctacac gtggttcgac ccgtggggcc agggaaccct ggtcaccgtc      420

tcctcagcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      540

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc cgtcctacag      600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      720

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      780

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            1419


<210>  6
<211>  456
<212>  PRT
<213>  ˹

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Asn Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Thr Pro Asp Ser Gly Asp Asn Gly Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Gly Thr Ala Asp Cys Ser Ser Gly Gly Ser Cys Tyr Thr Trp 
            100                 105                 110         


Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  7
<211>  699
<212>  DNA
<213>  ˹

<400>  7
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggctc gtctgagctg       60

actcaggacc ctgctgtgtc tgtggccttg ggacagacag tcaggatcac atgccaagga      120

gacagagcgc tgagaagcta ctacgcaagc tggtaccagc agaagccagg acaggcccct      180

gtacttgtca tctatggtaa aaccaaccgg ccctcaggga tcccagaccg attctctggc      240

tccagctcag gaaacacagc ttccttgacc atcactgggg ctcaggcgga agatgaggct      300

gactattact gtacctcccg ggacaacagt ggttaccatc tggtgttcgg cggagggacc      360

aagctgaccg tcctagtaac cgtggccgcc ccctccgtgt tcatcttccc cccctccgac      420

gagcagctga agtccggcac cgcctccgtg gtgtgcctgc tgaacaactt ctacccccgg      480

gaggccaagg tgcagtggaa ggtggacaac gccctgcagt ccggcaactc ccaggagtcc      540

gtgaccgagc aggactccaa ggactccacc tactccctgt cctccaccct gaccctgtcc      600

aaggccgact acgagaagca caaggtgtac gcctgcgagg ttacccacca gggcctgtcc      660

tcccccgtga ccaagtcctt caaccggggc gagtgctag                             699


<210>  8
<211>  216
<212>  PRT
<213>  ˹

<400>  8

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Arg Ala Leu Arg Ser Tyr Tyr 
            20                  25                  30          


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        35                  40                  45              


Tyr Gly Lys Thr Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Arg Asp Asn Ser Gly Tyr 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Val Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  9
<211>  38
<212>  DNA
<213>  ˹

<400>  9
ctgcaaccgg tgtacattcc caggtgcagc tggtgcag                               38


<210>  10
<211>  38
<212>  DNA
<213>  ˹

<400>  10
ctgcaaccgg tgtacattcc gaggtgcagc tggtgcag                               38


<210>  11
<211>  38
<212>  DNA
<213>  ˹

<400>  11
ctgcaaccgg tgtacattct gaggtgcagc tggtggag                               38


<210>  12
<211>  38
<212>  DNA
<213>  ˹

<400>  12
ctgcaaccgg tgtacattct gaggtgcagc tgttggag                               38


<210>  13
<211>  38
<212>  DNA
<213>  ˹

<400>  13
ctgcaaccgg tgtacattcc caggtgcagc tgcaggag                               38


<210>  14
<211>  40
<212>  DNA
<213>  ˹

<400>  14
ctgcaaccgg tgtacattcc caggtgcagc tacagcagtg                             40


<210>  15
<211>  38
<212>  DNA
<213>  ˹

<400>  15
ctgcaaccgg tgtacattcc caggttcagc tggtgcag                               38


<210>  16
<211>  38
<212>  DNA
<213>  ˹

<400>  16
ctgcaaccgg tgtacattcc caggtccagc tggtacag                               38


<210>  17
<211>  38
<212>  DNA
<213>  ˹

<400>  17
ctgcaaccgg tgtacattct caggtgcagc tggtggag                               38


<210>  18
<211>  38
<212>  DNA
<213>  ˹

<400>  18
ctgcaaccgg tgtacattct gaagtgcagc tggtggag                               38


<210>  19
<211>  38
<212>  DNA
<213>  ˹

<400>  19
ctgcaaccgg tgtacattcc cagctgcagc tgcaggag                               38


<210>  20
<211>  38
<212>  DNA
<213>  ˹

<400>  20
ctgcaaccgg tgtacattcc caggtacagc tgcagcag                               38


<210>  21
<211>  32
<212>  DNA
<213>  ˹

<400>  21
tgcgaagtcg acgctgagga gacggtgacc ag                                     32


<210>  22
<211>  34
<212>  DNA
<213>  ˹

<400>  22
tgcgaagtcg acgctgaaga gacggtgacc attg                                   34


<210>  23
<211>  33
<212>  DNA
<213>  ˹

<400>  23
tgcgaagtcg acgctgagga gacggtgacc gtg                                    33


<210>  24
<211>  40
<212>  DNA
<213>  ˹

<400>  24
ctgcaaccgg tgtacattct gacatccaga tgacccagtc                             40


<210>  25
<211>  46
<212>  DNA
<213>  ˹

<400>  25
ttgtgctgca accggtgtac attcagacat ccagttgacc cagtct                      46


<210>  26
<211>  40
<212>  DNA
<213>  ˹

<400>  26
ctgcaaccgg tgtacattgt gccatccgga tgacccagtc                             40


<210>  27
<211>  40
<212>  DNA
<213>  ˹

<400>  27
ctgcaaccgg tgtacatggg gatattgtga tgacccagac                             40


<210>  28
<211>  40
<212>  DNA
<213>  ˹

<400>  28
ctgcaaccgg tgtacatggg gatattgtga tgactcagtc                             40


<210>  29
<211>  40
<212>  DNA
<213>  ˹

<400>  29
ctgcaaccgg tgtacatggg gatgttgtga tgactcagtc                             40


<210>  30
<211>  45
<212>  DNA
<213>  ˹

<400>  30
ttgtgctgca accggtgtac attcagaaat tgtgttgaca cagtc                       45


<210>  31
<211>  40
<212>  DNA
<213>  ˹

<400>  31
ctgcaaccgg tgtacattca gaaatagtga tgacgcagtc                             40


<210>  32
<211>  46
<212>  DNA
<213>  ˹

<400>  32
ttgtgctgca accggtgtac attcagaaat tgtgttgacg cagtct                      46


<210>  33
<211>  40
<212>  DNA
<213>  ˹

<400>  33
ctgcaaccgg tgtacattcg gacatcgtga tgacccagtc                             40


<210>  34
<211>  30
<212>  DNA
<213>  ˹

<400>  34
gccaccgtac gtttgatytc caccttggtc                                        30


<210>  35
<211>  30
<212>  DNA
<213>  ˹

<400>  35
gccaccgtac gtttgatctc cagcttggtc                                        30


<210>  36
<211>  30
<212>  DNA
<213>  ˹

<400>  36
gccaccgtac gtttgatatc cactttggtc                                        30


<210>  37
<211>  30
<212>  DNA
<213>  ˹

<400>  37
gccaccgtac gtttaatctc cagtcgtgtc                                        30




