                         б

<110>  йѧԺȽоԺ
 
<120>  H7N9ȫԴ¡2G3ƷӦ

<130>  PCT1901135

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  375
<212>  DNA
<213>  ˹

<400>  1
caagtgcagc tggtggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata catattcacc agttatgaga tcaactgggt gcgacaggcc      120

actggccaag ggcttgagtg gatgggatgg atgaaccctg agagtggtga gacaggcttt      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataac cacagcctac      240

atggagctga gcagcctgac ttctgaggac acggccgtgt attactgtgc gacaggaaat      300

gcggaatgta gtggtggtag ctgctacaat tggttcgaac cctggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210>  2
<211>  114
<212>  PRT
<213>  ˹

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Glu Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Glu Ser Gly Glu Thr Gly Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Asn Ala Glu Cys Ser Gly Gly Ser Cys Tyr Asn Trp Phe 
            100                 105                 110         


Glu Pro 
        


<210>  3
<211>  327
<212>  DNA
<213>  ˹

<400>  3
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacaaact caaaagctat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaga aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactccaag gagaccagtg gttaccatct ggtgttcggc      300

ggagggacca agctgaccgt cctagta                                          327


<210>  4
<211>  109
<212>  PRT
<213>  ˹

<400>  4

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Lys Leu Lys Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Arg Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Lys Glu Thr Ser Gly Tyr His 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Val 
            100                 105                 


<210>  5
<211>  1416
<212>  DNA
<213>  ˹

<400>  5
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggcca agtgcagctg       60

gtggagtctg gggctgaggt gaagaagcct ggggcctcag tgaaggtctc ctgcaaggct      120

tctggataca tattcaccag ttatgagatc aactgggtgc gacaggccac tggccaaggg      180

cttgagtgga tgggatggat gaaccctgag agtggtgaga caggctttgc acagaagttc      240

cagggcagag tcaccatgac caggaacacc tccataacca cagcctacat ggagctgagc      300

agcctgactt ctgaggacac ggccgtgtat tactgtgcga caggaaatgc ggaatgtagt      360

ggtggtagct gctacaattg gttcgaaccc tggggccagg gaaccctggt caccgtctcc      420

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      480

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggccgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      660

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag      720

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaatga                               1416


<210>  6
<211>  455
<212>  PRT
<213>  ˹

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Glu Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Glu Ser Gly Glu Thr Gly Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Asn Ala Glu Cys Ser Gly Gly Ser Cys Tyr Asn Trp Phe 
            100                 105                 110         


Glu Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  7
<211>  696
<212>  DNA
<213>  ˹

<400>  7
atgggctggt cctgcatcat cctgttcctg gtggccaccg ccaccggctc gtctgagctg       60

actcaggacc ctgctgtgtc tgtggccttg ggacagacag tcaggatcac atgccaagga      120

gacaaactca aaagctatta tgcaagctgg taccagcaga agccaggaca ggcccctgta      180

cttgtcatct atggtagaaa caaccggccc tcagggatcc cagaccgatt ctctggctcc      240

agctcaggaa acacagcttc cttgaccatc actggggctc aggcggaaga tgaggctgac      300

tattactgta actccaagga gaccagtggt taccatctgg tgttcggcgg agggaccaag      360

ctgaccgtcc tagtaaccgt ggccgccccc tccgtgttca tcttcccccc ctccgacgag      420

cagctgaagt ccggcaccgc ctccgtggtg tgcctgctga acaacttcta cccccgggag      480

gccaaggtgc agtggaaggt ggacaacgcc ctgcagtccg gcaactccca ggagtccgtg      540

accgagcagg actccaagga ctccacctac tccctgtcct ccaccctgac cctgtccaag      600

gccgactacg agaagcacaa ggtgtacgcc tgcgaggtta cccaccaggg cctgtcctcc      660

cccgtgacca agtccttcaa ccggggcgag tgctag                                696


<210>  8
<211>  215
<212>  PRT
<213>  ˹

<400>  8

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Lys Leu Lys Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Arg Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Lys Glu Thr Ser Gly Tyr His 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Val Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  9
<211>  38
<212>  DNA
<213>  ˹

<400>  9
ctgcaaccgg tgtacattcc caggtgcagc tggtgcag                               38


<210>  10
<211>  38
<212>  DNA
<213>  ˹

<400>  10
ctgcaaccgg tgtacattcc gaggtgcagc tggtgcag                               38


<210>  11
<211>  38
<212>  DNA
<213>  ˹

<400>  11
ctgcaaccgg tgtacattct gaggtgcagc tggtggag                               38


<210>  12
<211>  38
<212>  DNA
<213>  ˹

<400>  12
ctgcaaccgg tgtacattct gaggtgcagc tgttggag                               38


<210>  13
<211>  38
<212>  DNA
<213>  ˹

<400>  13
ctgcaaccgg tgtacattcc caggtgcagc tgcaggag                               38


<210>  14
<211>  40
<212>  DNA
<213>  ˹

<400>  14
ctgcaaccgg tgtacattcc caggtgcagc tacagcagtg                             40


<210>  15
<211>  38
<212>  DNA
<213>  ˹

<400>  15
ctgcaaccgg tgtacattcc caggttcagc tggtgcag                               38


<210>  16
<211>  38
<212>  DNA
<213>  ˹

<400>  16
ctgcaaccgg tgtacattcc caggtccagc tggtacag                               38


<210>  17
<211>  38
<212>  DNA
<213>  ˹

<400>  17
ctgcaaccgg tgtacattct caggtgcagc tggtggag                               38


<210>  18
<211>  38
<212>  DNA
<213>  ˹

<400>  18
ctgcaaccgg tgtacattct gaagtgcagc tggtggag                               38


<210>  19
<211>  38
<212>  DNA
<213>  ˹

<400>  19
ctgcaaccgg tgtacattcc cagctgcagc tgcaggag                               38


<210>  20
<211>  38
<212>  DNA
<213>  ˹

<400>  20
ctgcaaccgg tgtacattcc caggtacagc tgcagcag                               38


<210>  21
<211>  32
<212>  DNA
<213>  ˹

<400>  21
tgcgaagtcg acgctgagga gacggtgacc ag                                     32


<210>  22
<211>  34
<212>  DNA
<213>  ˹

<400>  22
tgcgaagtcg acgctgaaga gacggtgacc attg                                   34


<210>  23
<211>  33
<212>  DNA
<213>  ˹

<400>  23
tgcgaagtcg acgctgagga gacggtgacc gtg                                    33


<210>  24
<211>  40
<212>  DNA
<213>  ˹

<400>  24
ctgcaaccgg tgtacattct gacatccaga tgacccagtc                             40


<210>  25
<211>  46
<212>  DNA
<213>  ˹

<400>  25
ttgtgctgca accggtgtac attcagacat ccagttgacc cagtct                      46


<210>  26
<211>  40
<212>  DNA
<213>  ˹

<400>  26
ctgcaaccgg tgtacattgt gccatccgga tgacccagtc                             40


<210>  27
<211>  40
<212>  DNA
<213>  ˹

<400>  27
ctgcaaccgg tgtacatggg gatattgtga tgacccagac                             40


<210>  28
<211>  40
<212>  DNA
<213>  ˹

<400>  28
ctgcaaccgg tgtacatggg gatattgtga tgactcagtc                             40


<210>  29
<211>  40
<212>  DNA
<213>  ˹

<400>  29
ctgcaaccgg tgtacatggg gatgttgtga tgactcagtc                             40


<210>  30
<211>  45
<212>  DNA
<213>  ˹

<400>  30
ttgtgctgca accggtgtac attcagaaat tgtgttgaca cagtc                       45


<210>  31
<211>  40
<212>  DNA
<213>  ˹

<400>  31
ctgcaaccgg tgtacattca gaaatagtga tgacgcagtc                             40


<210>  32
<211>  46
<212>  DNA
<213>  ˹

<400>  32
ttgtgctgca accggtgtac attcagaaat tgtgttgacg cagtct                      46


<210>  33
<211>  40
<212>  DNA
<213>  ˹

<400>  33
ctgcaaccgg tgtacattcg gacatcgtga tgacccagtc                             40


<210>  34
<211>  30
<212>  DNA
<213>  ˹

<400>  34
gccaccgtac gtttgatytc caccttggtc                                        30


<210>  35
<211>  30
<212>  DNA
<213>  ˹

<400>  35
gccaccgtac gtttgatctc cagcttggtc                                        30


<210>  36
<211>  30
<212>  DNA
<213>  ˹

<400>  36
gccaccgtac gtttgatatc cactttggtc                                        30


<210>  37
<211>  30
<212>  DNA
<213>  ˹

<400>  37
gccaccgtac gtttaatctc cagtcgtgtc                                        30




