                         SEQUENCE LISTING

<110>  ݿƼ޹˾
 
<120>  һְԭʶϸӦ

<130>  P19401357C

<150>  201811527903X
<151>  2018-12-13

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp 
1               5                   10                  15      


Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro 
            20                  25                  30          


Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala 
        35                  40                  45              


Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr 
    50                  55                  60                  


Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro 
65                  70                  75                  80  


Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile 
                85                  90                  95      


Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp 
            100                 105                 110         


Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val 
        115                 120                 125             


Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu 
    130                 135                 140                 


Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala 
145                 150                 155                 160 


Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg 
                165                 170                 175     


Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His 
            180                 185                 190         


His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile 
        195                 200                 205             


Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu 
    210                 215                 220                 


Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr 
225                 230                 235                 240 


Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile 
                245                 250                 255     


Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val 
            260                 265                 270         


Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr 
        275                 280                 285             


Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp 
    290                 295                 300                 


Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp 
305                 310                 315                 320 


Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu 
                325                 330                 335     


Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys 
            340                 345                 350         


Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp 
        355                 360                 365             


Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr Val Arg Gly 
    370                 375                 380                 


Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys 
385                 390                 395                 400 


Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp 
                405                 410                 415     


Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala 
            420                 425                 430         


Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile Phe Tyr Asn 
        435                 440                 445             


Ala Ser Pro Ser Thr Leu Ser 
    450                 455 


<210>  2
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  2
ctgaatttca gagcacctcc tgttattcca aatgtgcctt tcctctgggc ctggaatgcc       60

ccaagtgaat tttgtcttgg aaaatttgat gagccactag atatgagcct cttctctttc      120

ataggaagcc cccgaataaa cgccaccggg caaggtgtta caatatttta tgttgataga      180

cttggctact atccttacat agattcaatc acaggagtaa ctgtgaatgg aggaatcccc      240

cagaagattt ccttacaaga ccatctggac aaagctaaga aagacattac attttatatg      300

ccagtagaca atttgggaat ggctgttatt gactgggaag aatggagacc cacttgggca      360

agaaactgga aacctaaaga tgtttacaag aataggtcta ttgaattggt tcagcaacaa      420

aatgtacaac ttagtctcac agaggccact gagaaagcaa aacaagaatt tgaaaaggca      480

gggaaggatt tcctggtaga gactataaaa ttgggaaaat tacttcggcc aaatcacttg      540

tggggttatt atctttttcc ggattgttac aaccatcact ataagaaacc cggttacaat      600

ggaagttgct tcaatgtaga aataaaaaga aatgatgatc tcagctggtt gtggaatgaa      660

agcactgctc tttacccatc catttatttg aacactcagc agtctcctgt agctgctaca      720

ctctatgtgc gcaatcgagt tcgggaagcc atcagagttt ccaaaatacc tgatgcaaaa      780

agtccacttc cggtttttgc atatacccgc atagttttta ctgatcaagt tttgaaattc      840

ctttctcaag atgaacttgt gtatacattt ggcgaaactg ttgctctggg tgcttctgga      900

attgtaatat ggggaaccct cagtataatg cgaagtatga aatcttgctt gctcctagac      960

aattacatgg agactatact gaatccttac ataatcaacg tcacactagc agccaaaatg     1020

tgtagccaag tgctttgcca ggagcaagga gtgtgtataa ggaaaaactg gaattcaagt     1080

gactatcttc acctcaaccc agataatttt gctattcaac ttgagaaagg tggaaagttc     1140

acagtacgtg gaaaaccgac acttgaagac ctggagcaat tttctgaaaa attttattgc     1200

agctgttata gcaccttgag ttgtaaggag aaagctgatg taaaagacac tgatgctgtt     1260

gatgtgtgta ttgctgatgg tgtctgtata gatgcttttc taaaacctcc catggagaca     1320

gaagaacctc aaattttcta caatgcttca ccctccacac tatct                     1365


<210>  3
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PH20

<400>  3
ctgaacttca gagccccccc tgtgatcccc aacgtgcctt tcctgtgggc ctggaatgcc       60

ccaagcgagt tctgcctggg caagtttgac gagcccctgg atatgtctct gttcagcttt      120

atcggctccc ccagaatcaa tgccaccggc cagggcgtga caatctttta cgtggacagg      180

ctgggctact atccttatat cgattccatc accggcgtga cagtgaacgg cggcatccca      240

cagaagatca gcctgcagga ccacctggat aaggccaaga aggatatcac cttctacatg      300

cccgtggaca atctgggcat ggccgtgatc gattgggagg agtggcgccc aacatgggcc      360

agaaactgga agcccaagga cgtgtataag aatcgctcta tcgagctggt gcagcagcag      420

aacgtgcagc tgagcctgac cgaggccaca gagaaggcca agcaggagtt cgagaaggcc      480

ggcaaggact ttctggtgga gaccatcaag ctgggcaagc tgctgagacc caaccacctg      540

tggggctact atctgtttcc tgattgctac aatcaccact ataagaagcc aggctacaac      600

ggctcttgtt tcaatgtgga gatcaagagg aacgacgatc tgagctggct gtggaatgag      660

tccacagccc tgtacccctc tatctatctg aacacccagc agtcccctgt ggccgccaca      720

ctgtatgtgc ggaatagagt gagggaggcc atccgcgtga gcaagatccc tgacgccaag      780

tcccctctgc cagtgttcgc ctacacccgg atcgtgttta cagaccaggt gctgaagttc      840

ctgagccagg atgagctggt gtataccttc ggcgagacag tggccctggg cgccagcgga      900

atcgtgatct ggggcaccct gtccatcatg cggtccatga agtcttgcct gctgctggat      960

aactacatgg agaccatcct gaacccctat atcatcaatg tgacactggc cgccaagatg     1020

tgcagccagg tgctgtgcca ggagcagggc gtgtgcatcc gcaagaactg gaacagcagc     1080

gattacctgc acctgaaccc cgacaatttt gccatccagc tggagaaggg cggcaagttc     1140

accgtgcggg gcaagcctac actggaggac ctggagcagt tctccgagaa gttttactgc     1200

agctgttatt ccaccctgtc ttgtaaggag aaggccgatg tgaaggacac agatgccgtg     1260

gacgtgtgca tcgccgatgg cgtgtgcatc gacgcctttc tgaagccacc catggagacc     1320

gaggagcctc agattttcta caatgccagc ccatccaccc tgtct                     1365


<210>  4
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ROR1 scFv

<400>  4
caggtacagc tgaaggagag cggtcccggc ctggtggccc cctctcagac cctgagcata       60

acctgcaccg tgagcggatt cagcctgacc agctacgggg tgcactgggt gaggcagcct      120

cccggcaagg gcctggagtg gctgggcgtg atctgggccg gtggcttcac caactacaac      180

agcgccctga agtctcgact gtcaatctca aaggacaatt ctaagagcca ggtgctgctc      240

aaaatgacat cattgcagac cgacgacacc gccatgtact actgcgccag gaggggcagc      300

tcctacagca tggactactg gggccagggc acaagcgtga cggtgtcatc aggaggcggt      360

gggagtgggg gaggagggag cggtggcgga ggcagtgaga tcgtgctgtc tcagagcccc      420

gcaattactg ccgccagcct gggccaaaaa gtgaccataa catgcagcgc cagtagcaac      480

gtaagctaca tccactggta tcaacaaagg agcggaacca gccctaggcc ctggatctac      540

gagatcagca agctggcctc tggcgtgccc gtgaggttta gcggctcagg cagcggcact      600

tcttacagct tgacaatcag cagtatggag gccgaggacg ccgccatcta ttattgccag      660

cagtggaact accccctgat caccttcggc tctgggacca agttggagat c               711


<210>  5
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GPC3 scFv

<400>  5
gacgtggtga tgacccagag cccactgtct ctgcccgtga cccccggaga gcccgccagc       60

atctcctgta ggagtagtca gagccttgta cacagcaacg ccaacaccta cctgcattgg      120

tatctgcaaa agcccggtca aagcccacag ctcctgatct acaaggtgag caacaggttt      180

tcaggcgtgc cggatcggtt cagtgggtct gggagcggca ccgacttcac cctgaagatc      240

agcagggtcg aggccgagga cgtgggcgtg tactattgct ctcagaacac ccacgtgccc      300

cccaccttcg gccagggcac caagctggag atcaagaggg ggggaggagg tagcgggggt      360

ggaggcagcg gcggtggcgg tagccaggtg caactggtcc agtccggcgc agaggtgaag      420

aaaccaggcg ccagcgtgaa ggtcagctgc aaggcaagcg gctacacctt taccgattac      480

gagatgcact gggtgaggca ggcaccggga cagggcctgg agtggatggg agcccttgat      540

cccaagaccg gggacacggc atacagccag aagttcaaag gtcgagtgac cctgaccgcc      600

gacgagagca ccagcacggc ctacatggag ctgagcagcc tgaggagcga ggacaccgca      660

gtgtattact gcaccaggtt ctatagctac acttactggg ggcagggtac tctggtgaca      720

gtgtctagc                                                              729


<210>  6
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EpCAM scFv

<400>  6
gacatcgtga tgacccagag cgccttcagc aaccccgtga ccctgggcac cagcgccagc       60

atcagctgca ggagcaccaa gagcctgctg cacagcaacg gcatcactta cctgtactgg      120

tacctgcaaa agccgggtca gagcccccag ctcctgattt accaaatgag caatttggcc      180

agcggtgtgc ccgacaggtt cagctctagc ggcagcggca ccgactttac cctgaggatc      240

agcagggtgg aggccgagga cgtgggcgtg tactactgcg ctcaaaatct ggagataccc      300

aggacctttg gcggtggcac gaagctggaa atcaagaggg ggggtggcgg ttcaggtggg      360

ggagggagcg gaggaggcgg gagccaggtg cagctccagc agagcggccc agaacttaag      420

aagccagggg aaaccgtgaa gattagctgc aaggcctctg gctacacctt caccaactac      480

ggcatgaact gggttaagca agcacccgga aggggcctga agtggatggg ctggatcaat      540

acctacaccg gcgagagcac ctacgccgac gacttcaaag gcaggttcgc tttctctctg      600

gaaacgtctg ccagcgcagc ctacttgcag atcaacaact tgaagaacga ggacaccgca      660

acctacttct gcgccaggtt tgctatcaag ggggactact ggggccaagg aaccactctc      720

acagtttcaa gc                                                          732


<210>  7
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ź

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser 
            20              


<210>  8
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  8

Met His Cys Glu Arg Phe Leu Cys Ile Leu Arg Ile Ile Gly Thr Thr 
1               5                   10                  15      


Leu Phe Gly Val Ser Leu Leu Leu Gly Ile Thr Ala Ala Tyr Ile Val 
            20                  25                  30          


Gly Tyr Gln Phe Ile Gln Thr Asp Asn Tyr Tyr Phe Ser Phe Gly Leu 
        35                  40                  45              


Tyr Gly Ala Phe Leu Ala Ser His Leu Ile Ile Gln Ser Leu Phe Ala 
    50                  55                  60                  


Phe Leu Glu His Arg Lys Met Lys Lys Ser Leu Glu Thr Pro Ile Lys 
65                  70                  75                  80  


Leu Asn Lys Thr Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu Asp Pro 
                85                  90                  95      


Asp Tyr Leu Arg Lys Cys Leu Gln Ser Val Lys Arg Leu Thr Tyr Pro 
            100                 105                 110         


Gly Ile Lys Val Val Met Val Ile Asp Gly Asn Ser Glu Asp Asp Leu 
        115                 120                 125             


Tyr Met Met Asp Ile Phe Ser Glu Val Met Gly Arg Asp Lys Ser Ala 
    130                 135                 140                 


Thr Tyr Ile Trp Lys Asn Asn Phe His Glu Lys Gly Pro Gly Glu Thr 
145                 150                 155                 160 


Asp Glu Ser His Lys Glu Ser Ser Gln His Val Thr Gln Leu Val Leu 
                165                 170                 175     


Ser Asn Lys Ser Ile Cys Ile Met Gln Lys Trp Gly Gly Lys Arg Glu 
            180                 185                 190         


Val Met Tyr Thr Ala Phe Arg Ala Leu Gly Arg Ser Val Asp Tyr Val 
        195                 200                 205             


Gln Val Cys Asp Ser Asp Thr Met Leu Asp Pro Ala Ser Ser Val Glu 
    210                 215                 220                 


Met Val Lys Val Leu Glu Glu Asp Pro Met Val Gly Gly Val Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ile Leu Asn Lys Tyr Asp Ser Trp Ile Ser Phe Leu Ser 
                245                 250                 255     


Ser Val Arg Tyr Trp Met Ala Phe Asn Ile Glu Arg Ala Cys Gln Ser 
            260                 265                 270         


Tyr Phe Gly Cys Val Gln Cys Ile Ser Gly Pro Leu Gly Met Tyr Arg 
        275                 280                 285             


Asn Ser Leu Leu His Glu Phe Val Glu Asp Trp Tyr Asn Gln Glu Phe 
    290                 295                 300                 


Met Gly Asn Gln Cys Ser Phe Gly Asp Asp Arg His Leu Thr Asn Arg 
305                 310                 315                 320 


Val Leu Ser Leu Gly Tyr Ala Thr Lys Tyr Thr Ala Arg Ser Lys Cys 
                325                 330                 335     


Leu Thr Glu Thr Pro Ile Glu Tyr Leu Arg Trp Leu Asn Gln Gln Thr 
            340                 345                 350         


Arg Trp Ser Lys Ser Tyr Phe Arg Glu Trp Leu Tyr Asn Ala Met Trp 
        355                 360                 365             


Phe His Lys His His Leu Trp Met Thr Tyr Glu Ala Ile Ile Thr Gly 
    370                 375                 380                 


Phe Phe Pro Phe Phe Leu Ile Ala Thr Val Ile Gln Leu Phe Tyr Arg 
385                 390                 395                 400 


Gly Lys Ile Trp Asn Ile Leu Leu Phe Leu Leu Thr Val Gln Leu Val 
                405                 410                 415     


Gly Leu Ile Lys Ser Ser Phe Ala Ser Cys Leu Arg Gly Asn Ile Val 
            420                 425                 430         


Met Val Phe Met Ser Leu Tyr Ser Val Leu Tyr Met Ser Ser Leu Leu 
        435                 440                 445             


Pro Ala Lys Met Phe Ala Ile Ala Thr Ile Asn Lys Ala Gly Trp Gly 
    450                 455                 460                 


Thr Ser Gly Arg Lys Thr Ile Val Val Asn Phe Ile Gly Leu Ile Pro 
465                 470                 475                 480 


Val Ser Val Trp Phe Thr Ile Leu Leu Gly Gly Val Ile Phe Thr Ile 
                485                 490                 495     


Tyr Lys Glu Ser Lys Arg Pro Phe Ser Glu Ser Lys Gln Thr Val Leu 
            500                 505                 510         


Ile Val Gly Thr Leu Leu Tyr Ala Cys Tyr Trp Val Met Leu Leu Thr 
        515                 520                 525             


Leu Tyr Val Val Leu Ile Asn Lys Cys Gly Arg Arg Lys Lys Gly Gln 
    530                 535                 540                 


Gln Tyr Asp Met Val Leu Asp Val 
545                 550         


<210>  9
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr Arg Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Ala Pro Arg Arg Pro Leu 
                405                 410                 415     


Pro Gln Val Ala Thr Leu Ile Asp Arg Phe Val Lys Gly Arg Gly Gln 
            420                 425                 430         


Leu Asp Lys Asp Thr Leu Asp Thr Leu Thr Ala Phe Tyr Pro Gly Tyr 
        435                 440                 445             


Leu Cys Ser Leu Ser Pro Glu Glu Leu Ser Ser Val Pro Pro Ser Ser 
    450                 455                 460                 


Ile Trp Ala Val Arg Pro Gln Asp Leu Asp Thr Cys Asp Pro Arg Gln 
465                 470                 475                 480 


Leu Asp Val Leu Tyr Pro Lys Ala Arg Leu Ala Phe Gln Asn Met Asn 
                485                 490                 495     


Gly Ser Glu Tyr Phe Val Lys Ile Gln Ser Phe Leu Gly Gly Ala Pro 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Gln Gln Asn Val Ser Met Asp Leu 
        515                 520                 525             


Ala Thr Phe Met Lys Leu Arg Thr Asp Ala Val Leu Pro Leu Thr Val 
    530                 535                 540                 


Ala Glu Val Gln Lys Leu Leu Gly Pro His Val Glu Gly Leu Lys Ala 
545                 550                 555                 560 


Glu Glu Arg His Arg Pro Val Arg Asp Trp Ile Leu Arg Gln Arg Gln 
                565                 570                 575     


Asp Asp Leu Asp Thr Leu Gly Leu Gly Leu Gln Gly Gly Ile Pro Asn 
            580                 585                 590         


Gly Tyr Leu Val Leu Asp Leu Ser Met Gln Glu Ala Leu Ser Gly Thr 
        595                 600                 605             


Pro Cys Leu Leu Gly Pro Gly Pro Val Leu Thr Val Leu Ala Leu Leu 
    610                 615                 620                 


Leu Ala Ser Thr Leu Ala 
625                 630 


<210>  10
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser 
            20                  25                  30          


Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser 
        35                  40                  45              


Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser 
    50                  55                  60                  


Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys 
65                  70                  75                  80  


Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu 
                85                  90                  95      


Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly 
            100                 105                 110         


Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn 
        115                 120                 125             


Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp 
    130                 135                 140                 


Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn 
145                 150                 155                 160 


Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser 
                165                 170                 175     


Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala 
            180                 185                 190         


Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val 
        195                 200                 205             


Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn 
    210                 215                 220                 


Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile 
225                 230                 235                 240 


Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr 
                245                 250                 255     


Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly 
            260                 265                 270         


Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn 
        275                 280                 285             


Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys 
    290                 295                 300                 


His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys 
305                 310                 315                 320 


Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly 
                325                 330                 335     


Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
            340                 345                 350         


<210>  11
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  11

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  12
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  12

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  13
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  14
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  15

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  16
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSLN scFv

<400>  16

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 


<210>  17
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2 scFv

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser His Lys Phe 
    130                 135                 140                 


Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
145                 150                 155                 160 


Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
    210                 215                 220                 


His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  18
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E6 TCR

<400>  18

Met Ala Leu Glu His Leu Leu Ile Ile Leu Trp Met Gln Leu Thr Trp 
1               5                   10                  15      


Val Ser Gly Gln Gln Leu Asn Gln Ser Pro Gln Ser Met Phe Ile Gln 
            20                  25                  30          


Glu Gly Glu Asp Val Ser Met Asn Cys Thr Ser Ser Ser Ile Phe Asn 
        35                  40                  45              


Thr Trp Leu Trp Tyr Lys Gln Asp Pro Gly Glu Gly Pro Val Leu Leu 
    50                  55                  60                  


Ile Ala Leu Tyr Lys Ala Gly Glu Leu Thr Ser Asn Gly Arg Leu Thr 
65                  70                  75                  80  


Ala Gln Phe Gly Ile Thr Arg Lys Asp Ser Phe Leu Asn Ile Ser Ala 
                85                  90                  95      


Ser Ile Pro Ser Asp Val Gly Ile Tyr Phe Cys Ala Gly His Pro Ser 
            100                 105                 110         


Ser Asn Ser Gly Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu 
        115                 120                 125             


Val Thr Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg 
            260                 265                 270         


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
        275                 280                 285             


Val Glu Glu Asn Pro Gly Pro Met Gly Thr Ser Leu Leu Cys Trp Val 
    290                 295                 300                 


Val Leu Gly Phe Leu Gly Thr Asp His Thr Gly Ala Gly Val Ser Gln 
305                 310                 315                 320 


Ser Pro Arg Tyr Lys Val Thr Lys Arg Gly Gln Asp Val Ala Leu Arg 
                325                 330                 335     


Cys Asp Pro Ile Ser Gly His Val Ser Leu Tyr Trp Tyr Arg Gln Ala 
            340                 345                 350         


Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Asn Tyr Glu Ala Gln 
        355                 360                 365             


Gln Asp Lys Ser Gly Leu Pro Asn Asp Arg Phe Ser Ala Glu Arg Pro 
    370                 375                 380                 


Glu Gly Ser Ile Ser Thr Leu Thr Ile Gln Arg Thr Glu Gln Arg Asp 
385                 390                 395                 400 


Ser Ala Met Tyr Arg Cys Ala Ser Ser Ser Gln Thr Gly Ala Arg Thr 
                405                 410                 415     


Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp 
            420                 425                 430         


Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys 
        435                 440                 445             


Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg 
    450                 455                 460                 


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
465                 470                 475                 480 


Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser 
                485                 490                 495     


Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
            500                 505                 510         


Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly 
        515                 520                 525             


Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr 
    530                 535                 540                 


Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr 
545                 550                 555                 560 


Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
                565                 570                 575     


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu 
            580                 585                 590         


Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600             


<210>  19
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPC3 scFv

<400>  19

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
145                 150                 155                 160 


Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                165                 170                 175     


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
            180                 185                 190         


Lys Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  20
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ROR1 scFv

<400>  20

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Phe Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Thr Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Gly Ser Ser Tyr Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Ile Val Leu Ser Gln Ser Pro Ala Ile Thr Ala 
    130                 135                 140                 


Ala Ser Leu Gly Gln Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Asn 
145                 150                 155                 160 


Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Ser Gly Thr Ser Pro Arg 
                165                 170                 175     


Pro Trp Ile Tyr Glu Ile Ser Lys Leu Ala Ser Gly Val Pro Val Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
        195                 200                 205             


Met Glu Ala Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Trp Asn Tyr 
    210                 215                 220                 


Pro Leu Ile Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235         


<210>  21
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpCam scfv

<400>  21

Asp Ile Val Met Thr Gln Ser Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
    130                 135                 140                 


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
145                 150                 155                 160 


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Arg Gly Leu Lys Trp Met 
                165                 170                 175     


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Asp Phe 
            180                 185                 190         


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ala Ala Tyr 
        195                 200                 205             


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  22
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  22

Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp 
1               5                   10                  15      


Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro 
            20                  25                  30          


Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala 
        35                  40                  45              


Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr 
    50                  55                  60                  


Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro 
65                  70                  75                  80  


Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile 
                85                  90                  95      


Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp 
            100                 105                 110         


Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val 
        115                 120                 125             


Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu 
    130                 135                 140                 


Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala 
145                 150                 155                 160 


Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg 
                165                 170                 175     


Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His 
            180                 185                 190         


His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile 
        195                 200                 205             


Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu 
    210                 215                 220                 


Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr 
225                 230                 235                 240 


Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile 
                245                 250                 255     


Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val 
            260                 265                 270         


Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr 
        275                 280                 285             


Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp 
    290                 295                 300                 


Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp 
305                 310                 315                 320 


Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu 
                325                 330                 335     


Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys 
            340                 345                 350         


Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp 
        355                 360                 365             


Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr Val Arg Gly 
    370                 375                 380                 


Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys 
385                 390                 395                 400 


Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp 
                405                 410                 415     


Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala 
            420                 425                 430         


Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile Phe Tyr 
        435                 440                 445         


<210>  23
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  23
ctgaatttca gagcacctcc tgttattcca aatgtgcctt tcctctgggc ctggaatgcc       60

ccaagtgaat tttgtcttgg aaaatttgat gagccactag atatgagcct cttctctttc      120

ataggaagcc cccgaataaa cgccaccggg caaggtgtta caatatttta tgttgataga      180

cttggctact atccttacat agattcaatc acaggagtaa ctgtgaatgg aggaatcccc      240

cagaagattt ccttacaaga ccatctggac aaagctaaga aagacattac attttatatg      300

ccagtagaca atttgggaat ggctgttatt gactgggaag aatggagacc cacttgggca      360

agaaactgga aacctaaaga tgtttacaag aataggtcta ttgaattggt tcagcaacaa      420

aatgtacaac ttagtctcac agaggccact gagaaagcaa aacaagaatt tgaaaaggca      480

gggaaggatt tcctggtaga gactataaaa ttgggaaaat tacttcggcc aaatcacttg      540

tggggttatt atctttttcc ggattgttac aaccatcact ataagaaacc cggttacaat      600

ggaagttgct tcaatgtaga aataaaaaga aatgatgatc tcagctggtt gtggaatgaa      660

agcactgctc tttacccatc catttatttg aacactcagc agtctcctgt agctgctaca      720

ctctatgtgc gcaatcgagt tcgggaagcc atcagagttt ccaaaatacc tgatgcaaaa      780

agtccacttc cggtttttgc atatacccgc atagttttta ctgatcaagt tttgaaattc      840

ctttctcaag atgaacttgt gtatacattt ggcgaaactg ttgctctggg tgcttctgga      900

attgtaatat ggggaaccct cagtataatg cgaagtatga aatcttgctt gctcctagac      960

aattacatgg agactatact gaatccttac ataatcaacg tcacactagc agccaaaatg     1020

tgtagccaag tgctttgcca ggagcaagga gtgtgtataa ggaaaaactg gaactcaagt     1080

gactatcttc acctcaaccc agataatttt gctattcaac ttgagaaagg tggaaagttc     1140

acagtacgtg gaaaaccgac acttgaagac ctggagcaat tttctgaaaa attttattgc     1200

agctgttata gcaccttgag ttgtaaggag aaagctgatg taaaagacac tgatgctgtt     1260

gatgtgtgta ttgctgatgg tgtctgtata gatgcttttc taaaacctcc catggagaca     1320

gaagaacctc aaattttcta ctaa                                            1344


<210>  24
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PH20Ż

<400>  24
ctgaacttca gagccccccc tgtgatcccc aacgtgcctt tcctgtgggc ctggaatgcc       60

ccaagcgagt tctgcctggg caagtttgac gagcccctgg atatgtctct gttcagcttt      120

atcggctccc ccagaatcaa tgccaccggc cagggcgtga caatctttta cgtggacagg      180

ctgggctact atccttatat cgattccatc accggcgtga cagtgaacgg cggcatccca      240

cagaagatca gcctgcagga ccacctggat aaggccaaga aggatatcac cttctacatg      300

cccgtggaca atctgggcat ggccgtgatc gattgggagg agtggcgccc aacatgggcc      360

agaaactgga agcccaagga cgtgtataag aatcgctcta tcgagctggt gcagcagcag      420

aacgtgcagc tgagcctgac cgaggccaca gagaaggcca agcaggagtt cgagaaggcc      480

ggcaaggact ttctggtgga gaccatcaag ctgggcaagc tgctgagacc caaccacctg      540

tggggctact atctgtttcc tgattgctac aatcaccact ataagaagcc aggctacaac      600

ggctcttgtt tcaatgtgga gatcaagagg aacgacgatc tgagctggct gtggaatgag      660

tccacagccc tgtacccctc tatctatctg aacacccagc agtcccctgt ggccgccaca      720

ctgtatgtgc ggaatagagt gagggaggcc atccgcgtga gcaagatccc tgacgccaag      780

tcccctctgc cagtgttcgc ctacacccgg atcgtgttta cagaccaggt gctgaagttc      840

ctgagccagg atgagctggt gtataccttc ggcgagacag tggccctggg cgccagcgga      900

atcgtgatct ggggcaccct gtccatcatg cggtccatga agtcttgcct gctgctggat      960

aactacatgg agaccatcct gaacccctat atcatcaatg tgacactggc cgccaagatg     1020

tgcagccagg tgctgtgcca ggagcagggc gtgtgcatcc gcaagaactg gaacagcagc     1080

gattacctgc acctgaaccc cgacaatttt gccatccagc tggagaaggg cggcaagttc     1140

accgtgcggg gcaagcctac actggaggac ctggagcagt tctccgagaa gttttactgc     1200

agctgttatt ccaccctgtc ttgtaaggag aaggccgatg tgaaggacac agatgccgtg     1260

gacgtgtgca tcgccgatgg cgtgtgcatc gacgcctttc tgaagccacc catggagacc     1320

gaggagcctc agattttcta ctaa                                            1344


<210>  25
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HAS2ĺ

<400>  25
atgcattgtg agaggtttct atgtatcctg agaataattg gaaccacact ctttggagtc       60

tctctcctcc ttggaatcac agctgcttat attgttggct accagtttat ccaaacggat      120

aattactatt tctcttttgg actgtatggt gcctttttgg catcacacct catcatccaa      180

agcctgtttg cctttttgga gcaccgaaaa atgaaaaaat ccctagaaac ccccataaag      240

ttgaacaaaa cagttgccct ttgcatcgct gcctatcaag aagatccaga ctacttaagg      300

aaatgtttgc aatctgtgaa aaggctaacc taccctggga ttaaagttgt catggtcata      360

gatgggaact cagaagatga cctttacatg atggacatct tcagtgaagt catgggcaga      420

gacaaatcag ccacttatat ctggaagaac aacttccacg aaaagggtcc cggtgagaca      480

gatgagtcac ataaagaaag ctcgcaacac gtaacgcaat tggtcttgtc caacaaaagt      540

atctgcatca tgcaaaaatg gggtggaaaa agagaagtca tgtacacagc cttcagagca      600

ctgggacgaa gtgtggatta tgtacaggtt tgtgattcag acactatgct tgacccagcc      660

tcatctgtgg agatggtaaa agttttagaa gaagatccca tggttggagg tgttggggga      720

gatgtccaga ttttaaacaa gtacgattcc tggatctcat tcctcagcag tgtaagatat      780

tggatggctt ttaatataga aagggcctgt cagtcttatt ttgggtgtgt tcagtgcatt      840

agtggacctc tgggaatgta cagaaactcc ttgttgcatg agtttgtgga agattggtac      900

aatcaagaat ttatgggcaa ccaatgtagc tttggtgatg acaggcatct cacgaaccgg      960

gtgctgagcc tgggctatgc aacaaaatac acagctcgat ctaagtgcct tactgaaaca     1020

cctatagaat atctcagatg gctaaaccag cagacccgtt ggagcaagtc ctacttccga     1080

gaatggctgt acaatgcaat gtggtttcac aaacatcact tgtggatgac ctacgaagcg     1140

attatcactg gattctttcc tttctttctc attgccacag taatccagct cttctaccgg     1200

ggtaaaattt ggaacattct cctcttcttg ttaactgtcc agctagtagg tctcataaaa     1260

tcatcttttg ccagctgcct tagaggaaat atcgtcatgg tcttcatgtc tctctactca     1320

gtgttataca tgtcgagttt acttcccgcc aagatgtttg caattgcaac aataaacaaa     1380

gctgggtggg gcacatcagg aaggaaaacc attgttgtta atttcatagg actcattcca     1440

gtatcagttt ggtttacaat cctcctgggt ggtgtgattt tcaccattta taaggagtct     1500

aaaaggccat tttcagaatc caaacagaca gttctaattg ttggaacgtt gctctatgca     1560

tgctattggg tcatgctttt gacgctgtat gtagttctca tcaataagtg tggcaggcgg     1620

aagaagggac aacaatatga catggtgctt gatgtatga                            1659


<210>  26
<211>  1893
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSLNĺ

<400>  26
atggccttgc caacggctcg acccctgttg gggtcctgtg ggacccccgc cctcggcagc       60

ctcctgttcc tgctcttcag cctcggatgg gtgcagccct cgaggaccct ggctggagag      120

acagggcagg aggctgcgcc cctggacgga gtcctggcca acccacctaa catttccagc      180

ctctcccctc gccaactcct tggcttcccg tgtgcggagg tgtccggcct gagcacggag      240

cgtgtccggg agctggctgt ggccttggca cagaagaatg tcaagctctc aacagagcag      300

ctgcgctgtc tggctcaccg gctctctgag ccccccgagg acctggacgc cctcccattg      360

gacctgctgc tattcctcaa cccagatgcg ttctcggggc cccaggcctg cacccgtttc      420

ttctcccgca tcacgaaggc caatgtggac ctgctcccga ggggggctcc cgagcgacag      480

cggctgctgc ctgcggctct ggcctgctgg ggtgtgcggg ggtctctgct gagcgaggct      540

gatgtgcggg ctctgggagg cctggcttgc gacctgcctg ggcgctttgt ggccgagtcg      600

gccgaagtgc tgctaccccg gctggtgagc tgcccgggac ccctggacca ggaccagcag      660

gaggcagcca gggcggctct gcagggcggg ggacccccct acggcccccc gtcgacatgg      720

tctgtctcca cgatggacgc tctgcggggc ctgctgcccg tgctgggcca gcccatcatc      780

cgcagcatcc cgcagggcat cgtggccgcg tggcggcaac gctcctctcg ggacccatcc      840

tggcggcagc ctgaacggac catcctccgg ccgcggttcc ggcgggaagt ggagaagaca      900

gcctgtcctt caggcaagaa ggcccgcgag atagacgaga gcctcatctt ctacaagaag      960

tgggagctgg aagcctgcgt ggatgcggcc ctgctggcca cccagatgga ccgcgtgaac     1020

gccatcccct tcacctacga gcagctggac gtcctaaagc ataaactgga tgagctctac     1080

ccacaaggtt accccgagtc tgtgatccag cacctgggct acctcttcct caagatgagc     1140

cctgaggaca ttcgcaagtg gaatgtgacg tccctggaga ccctgaaggc tttgcttgaa     1200

gtcaacaaag ggcacgaaat gagtcctcag gctcctcggc ggcccctccc acaggtggcc     1260

accctgatcg accgctttgt gaagggaagg ggccagctag acaaagacac cctagacacc     1320

ctgaccgcct tctaccctgg gtacctgtgc tccctcagcc ccgaggagct gagctccgtg     1380

ccccccagca gcatctgggc ggtcaggccc caggacctgg acacgtgtga cccaaggcag     1440

ctggacgtcc tctatcccaa ggcccgcctt gctttccaga acatgaacgg gtccgaatac     1500

ttcgtgaaga tccagtcctt cctgggtggg gcccccacgg aggatttgaa ggcgctcagt     1560

cagcagaatg tgagcatgga cttggccacg ttcatgaagc tgcggacgga tgcggtgctg     1620

ccgttgactg tggctgaggt gcagaaactt ctgggacccc acgtggaggg cctgaaggcg     1680

gaggagcggc accgcccggt gcgggactgg atcctacggc agcggcagga cgacctggac     1740

acgctggggc tggggctaca gggcggcatc cccaacggct acctggtcct agacctcagc     1800

atgcaagagg ccctctcggg gacgccctgc ctcctaggac ctggacctgt tctcaccgtc     1860

ctggcactgc tcctagcctc caccctggcc tga                                  1893


<210>  27
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tEGFRĺ

<400>  27
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tcgcaaagtg       60

tgtaacggaa taggtattgg tgaatttaaa gactcactct ccataaatgc tacgaatatt      120

aaacacttca aaaactgcac ctccatcagt ggcgatctcc acatcctgcc ggtggcattt      180

aggggtgact ccttcacaca tactcctcct ctggatccac aggaactgga tattctgaaa      240

accgtaaagg aaatcacagg gtttttgctg attcaggctt ggcctgaaaa caggacggac      300

ctccatgcct ttgagaacct agaaatcata cgcggcagga ccaagcaaca tggtcagttt      360

tctcttgcag tcgtcagcct gaacataaca tccttgggat tacgctccct caaggagata      420

agtgatggag atgtgataat ttcaggaaac aaaaatttgt gctatgcaaa tacaataaac      480

tggaaaaaac tgtttgggac ctccggtcag aaaaccaaaa ttataagcaa cagaggtgaa      540

aacagctgca aggccacagg ccaggtctgc catgccttgt gctcccccga gggctgctgg      600

ggcccggagc ccagggactg cgtctcttgc cggaatgtca gccgaggcag ggaatgcgtg      660

gacaagtgca accttctgga gggtgagcca agggagtttg tggagaactc tgagtgcata      720

cagtgccacc cagagtgcct gcctcaggcc atgaacatca cctgcacagg acggggacca      780

gacaactgta tccagtgtgc ccactacatt gacggccccc actgcgtcaa gacctgcccg      840

gcaggagtca tgggagaaaa caacaccctg gtctggaagt acgcagacgc cggccatgtg      900

tgccacctgt gccatccaaa ctgcacctac ggatgcactg ggccaggtct tgaaggctgt      960

ccaacgaatg ggcctaagat cccgtccatc gccactggga tggtgggggc cctcctcttg     1020

ctgctggtgg tggccctggg gatcggcctc ttcatgtga                            1059


<210>  28
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8ĺ

<400>  28
accactaccc cagcaccgag gccacccacc ccggctccta ccatcgcctc ccagcctctg       60

tccctgcgtc cggaggcatg tagacccgca gctggtgggg ccgtgcatac ccggggtctt      120

gacttcgcct gcgat                                                       135


<210>  29
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8Ĥĺ

<400>  29
atctacattt gggcccctct ggctggtact tgcggggtcc tgctgctttc actcgtgatc       60

actctttact gt                                                           72


<210>  30
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BBĺ

<400>  30
aagcgcggtc ggaagaagct gctgtacatc tttaagcaac ccttcatgag gcctgtgcag       60

actactcaag aggaggacgg ctgttcatgc cggttcccag aggaggagga aggcggctgc      120

gaactg                                                                 126


<210>  31
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3ưĺ

<400>  31
cgcgtgaaat tcagccgcag cgcagatgct ccagcctaca agcaggggca gaaccagctc       60

tacaacgaac tcaatcttgg tcggagagag gagtacgacg tgctggacaa gcggagagga      120

cgggacccag aaatgggcgg gaagccgcgc agaaagaatc cccaagaggg cctgtacaac      180

gagctccaaa aggataagat ggcagaagcc tatagcgaga ttggtatgaa aggggaacgc      240

agaagaggca aaggccacga cggactgtac cagggactca gcaccgccac caaggacacc      300

tatgacgctc ttcacatgca ggccctgccg cctcgg                                336


<210>  32
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2Aĵĺ

<400>  32
gagggcagag gcagcctgct gacatgtggc gacgtggaag agaaccctgg cccc             54


<210>  33
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  źĵĺ

<400>  33
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatcc                                                               69


<210>  34
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MSLN scFvĺ

<400>  34
caggtacaac tgcagcagtc tgggcctgag ctggagaagc ctggcgcttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctacacca tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggactt attactcctt acaatggtgc ttctagctac      180

aaccagaagt tcaggggcaa ggccacatta actgtagaca agtcatccag cacagcctac      240

atggacctcc tcagtctgac atctgaagac tctgcagtct atttctgtgc aagggggggt      300

tacgacggga ggggttttga ctactggggc caagggacca cggtcaccgt ctcctcaggt      360

ggaggcggtt caggcggcgg tggctctagc ggtggtggat cggacatcga gctcactcag      420

tctccagcaa tcatgtctgc atctccaggg gagaaggtca ccatgacctg cagtgccagc      480

tcaagtgtaa gttacatgca ctggtaccag cagaagtcag gcacctcccc caaaagatgg      540

atttatgaca catccaaact ggcttctgga gtcccaggtc gcttcagtgg cagtgggtct      600

ggaaactctt actctctcac aatcagcagc gtggaggctg aagatgatgc aacttattac      660

tgccagcagt ggagtaagca ccctctcacg tacggtgctg ggacaaagtt ggaaatcaaa      720

agcagc                                                                 726


<210>  35
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HER2 scFvĺ

<400>  35
caggtacaac tgcagcagtc aggacctgaa ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cctctgggta tcctttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggacagg gtttaaagtg gatgggctgg attaacacct ccactggaga gtcaacattt      180

gctgatgact tcaagggacg gtttgacttc tctttggaaa cctctgccaa cactgcctat      240

ttgcagatca acaacctcaa aagtgaagac atggctacat atttctgtgc aagatgggag      300

gtttaccacg gctacgttcc ttactggggc caagggacca cggtcaccgt ttcctctggc      360

ggtggcggtt ctggtggcgg tggctccggc ggtggcggtt ctgacatcca gctgacccag      420

tctcacaaat tcctgtccac ttcagtagga gacagggtca gcatcacctg caaggccagt      480

caggatgtgt ataatgctgt tgcctggtat caacagaaac caggacaatc tcctaaactt      540

ctgatttact cggcatcctc ccggtacact ggagtccctt ctcgcttcac tggcagtggc      600

tctgggccgg atttcacttt caccatcagc agtgtgcagg ctgaagacct ggcagtttat      660

ttctgtcagc aacattttcg tactccattc acgttcggct cggggacaaa attggagatc      720

aaa                                                                    723


<210>  36
<211>  1812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E6 TCRĺ

<400>  36
atggcccttg aacatctgtt gataatactg tggatgcaac ttacctgggt atctggtcag       60

caattgaacc agtctccaca gtccatgttt atccaagaag gggaggacgt gtccatgaat      120

tgtacaagct ccagtatctt caacacgtgg ctgtggtaca aacaggatcc tggggaagga      180

ccagtactgt tgatagccct ctataaggcg ggcgaactga catccaatgg aagactcaca      240

gcccaattcg gaattacccg gaaggattct ttcctcaaca tctccgcgag tattccatct      300

gatgtaggaa tatacttctg tgcagggcat ccgtctagca acagtggata tgccctcaat      360

tttggaaagg gcacctccct gctggttacc ccagacattc agaaccccga accagccgta      420

tatcagttga aggacccaag atctcaggat agtacactct gtttgtttac ggactttgac      480

tcacaaatca acgtcccgaa gactatggaa agtggtacgt tcatcacaga taagacggtt      540

ctggacatga aggctatgga ctcaaagagc aacggggcaa ttgcttggtc caaccagaca      600

agctttacct gtcaggacat ttttaaggag actaatgcta cttatccctc cagcgacgtt      660

ccgtgtgatg cgactcttac cgagaagtct tttgagaccg atatgaatct caacttccag      720

aatctgtcag tgatgggtct gcggatcctg cttctgaagg ttgcaggatt caatcttctt      780

atgactctcc ggctctggtc ttcaagagcc aaaagaagtg gttctggcgc gacgaatttt      840

agtttgctta agcaagccgg agatgtggag gaaaatcctg gaccgatggg cacaagtttg      900

ctgtgctggg ttgtgttggg ctttctgggt acagatcata ctggggcggg agtctctcaa      960

agcccccgat acaaagtcac taaaagaggg caggatgtcg cgcttcgctg tgatcccatt     1020

agcgggcatg tctcccttta ttggtaccgg caggctttgg gacaaggacc ggagttcctc     1080

acttacttca actacgaagc gcagcaggac aagtccggtc tgcctaatga tagattcagc     1140

gccgagagac cggagggcag tatctctact cttacgatac aaagaacgga gcagcgagac     1200

tctgctatgt atagatgtgc aagttctagc cagacgggtg ctcgcacgga cactcaatat     1260

ttcggtcctg gtacaagatt gaccgtcttg gaggatctcc ggaacgtcac cccaccaaag     1320

gtcagtttgt ttgagccatc aaaggcggag atcgccaaca aacagaaagc tacgctcgtg     1380

tgtttggctc ggggcttctt cccagaccac gtagaacttt cctggtgggt caatggaaag     1440

gaggttcatt ccggagtgtc cactgatccc caagcgtaca aggaatccaa ctatagctac     1500

tgtctctcat ctcggctccg ggtgagtgcg acattctggc ataatcctcg gaaccacttt     1560

cgatgccaag tgcagtttca tgggttgagc gaggaagaca agtggcccga gggcagtcct     1620

aaaccagtca ctcaaaacat aagcgccgag gcatggggta gagccgattg tgggattact     1680

agcgcttcat accaacaagg ggtattgagc gctacaattc tttacgaaat tctcctcggc     1740

aaggcgacgc tctacgccgt actggtgtct actctcgtgg ttatggcaat ggtgaaacgg     1800

aaaaacagct aa                                                         1812


