                         SEQUENCE LISTING

<110>  Monash University
       The University of Western Australia
 
<120>  Modulation of CAM Activity

<130>  278475

<150>  AU 2018904691
<151>  2018-12-10

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  Synthetic

<400>  1

Met Lys Lys Ser Lys Thr Ala Ser Lys His Val Asn Lys Asp Leu Gly 
1               5                   10                  15      


Asn Met Glu Glu Asn Lys Lys Leu Glu Glu Asn Asn His Lys Thr Glu 
            20                  25                  30          


Ala 
    


<210>  2
<211>  61
<212>  PRT
<213>  Synthetic

<400>  2

Met Tyr Cys Val Arg Arg Lys Gly Gly Pro Cys Cys Arg Gln Arg Arg 
1               5                   10                  15      


Glu Lys Gly Ala Pro Pro Pro Gly Glu Pro Gly Leu Ser His Ser Gly 
            20                  25                  30          


Ser Glu Gln Pro Glu Gln Thr Gly Leu Leu Met Gly Gly Ala Ser Gly 
        35                  40                  45              


Gly Ala Arg Gly Gly Ser Gly Gly Phe Gly Asp Glu Cys 
    50                  55                  60      


<210>  3
<211>  55
<212>  PRT
<213>  Synthetic

<400>  3

Met Lys Lys Gly Lys Leu Pro Cys Arg Arg Ser Gly Lys Gln Glu Ile 
1               5                   10                  15      


Thr Leu Pro Pro Ser Arg Lys Ser Glu Leu Val Val Glu Val Lys Ser 
            20                  25                  30          


Asp Lys Leu Pro Glu Glu Met Gly Leu Leu Gln Gly Ser Ser Gly Asp 
        35                  40                  45              


Lys Arg Ala Pro Gly Asp Gln 
    50                  55  


<210>  4
<211>  27
<212>  PRT
<213>  Synthetic

<400>  4

Met Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys 
1               5                   10                  15      


Glu Met Gly Glu Met His Arg Glu Leu Asn Ala 
            20                  25          


<210>  5
<211>  42
<212>  PRT
<213>  Synthetic

<400>  5

Met Ser Val Arg Gln Lys Gly Ser Tyr Leu Thr His Glu Ala Ser Gly 
1               5                   10                  15      


Leu Asp Glu Gln Gly Glu Ala Arg Glu Ala Phe Leu Asn Gly Ser Asp 
            20                  25                  30          


Gly His Lys Arg Lys Glu Glu Phe Phe Ile 
        35                  40          


<210>  6
<211>  23
<212>  PRT
<213>  Synthetic

<400>  6

Met Lys His Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys 
1               5                   10                  15      


Leu Glu Glu Asn Asn His Lys 
            20              


<210>  7
<211>  22
<212>  PRT
<213>  Synthetic

<400>  7

Met Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
1               5                   10                  15      


Arg Ala Glu Leu Asn Gln 
            20          


<210>  8
<211>  44
<212>  PRT
<213>  Synthetic

<400>  8

Met Leu Trp Gln Arg Arg Gln Arg Arg Gly Glu Glu Arg Lys Ala Pro 
1               5                   10                  15      


Glu Asn Gln Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln Ala Glu 
            20                  25                  30          


Glu Pro Glu Ala Gly Glu Ser Ser Thr Gly Gly Pro 
        35                  40                  


<210>  9
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 
    130                 135                 140                 


Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 
            180                 185                 190         


Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Met Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 
305                 310                 315                 320 


Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
            500                 505                 510         


Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
        515                 520                 525             


Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
    530                 535                 540                 


Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 
545                 550                 555                 560 


Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                565                 570                 575     


Asn Asn His Lys Thr Glu Ala 
            580             


<210>  10
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 
                245                 250                 255     


His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 
                405                 410                 415     


Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 
            420                 425                 430         


Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro Gly Glu 
            580                 585                 590         


Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu Gln Thr Gly Leu 
        595                 600                 605             


Leu Met Gly Gly Ala Ser Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe 
    610                 615                 620                 


Gly Asp Glu Cys 
625             


<210>  11
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Gly Leu Asp Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Gly Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Asn Val Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser Arg Gly Val 
545                 550                 555                 560 


Val Ile Val Ala Val Ile Val Cys Ile Leu Val Leu Ala Val Leu Gly 
                565                 570                 575     


Ala Val Leu Tyr Phe Leu Tyr Lys Lys Gly Lys Leu Pro Cys Arg Arg 
            580                 585                 590         


Ser Gly Lys Gln Glu Ile Thr Leu Pro Pro Ser Arg Lys Ser Glu Leu 
        595                 600                 605             


Val Val Glu Val Lys Ser Asp Lys Leu Pro Glu Glu Met Gly Leu Leu 
    610                 615                 620                 


Gln Gly Ser Ser Gly Asp Lys Arg Ala Pro Gly Asp Gln Gly Glu Lys 
625                 630                 635                 640 


Tyr Ile Asp Leu Arg His 
                645     


<210>  12
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  13
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Arg Ala Arg Arg Phe Gln Trp Pro Leu Leu Leu Leu Trp Ala 
1               5                   10                  15      


Ala Ala Ala Gly Pro Gly Ala Gly Gln Glu Val Gln Thr Glu Asn Val 
            20                  25                  30          


Thr Val Ala Glu Gly Gly Val Ala Glu Ile Thr Cys Arg Leu His Gln 
        35                  40                  45              


Tyr Asp Gly Ser Ile Val Val Ile Gln Asn Pro Ala Arg Gln Thr Leu 
    50                  55                  60                  


Phe Phe Asn Gly Thr Arg Ala Leu Lys Asp Glu Arg Phe Gln Leu Glu 
65                  70                  75                  80  


Glu Phe Ser Pro Arg Arg Val Arg Ile Arg Leu Ser Asp Ala Arg Leu 
                85                  90                  95      


Glu Asp Glu Gly Gly Tyr Phe Cys Gln Leu Tyr Thr Glu Asp Thr His 
            100                 105                 110         


His Gln Ile Ala Thr Leu Thr Val Leu Val Ala Pro Glu Asn Pro Val 
        115                 120                 125             


Val Glu Val Arg Glu Gln Ala Val Glu Gly Gly Glu Val Glu Leu Ser 
    130                 135                 140                 


Cys Leu Val Pro Arg Ser Arg Pro Ala Ala Thr Leu Arg Trp Tyr Arg 
145                 150                 155                 160 


Asp Arg Lys Glu Leu Lys Gly Val Ser Ser Ser Gln Glu Asn Gly Lys 
                165                 170                 175     


Val Trp Ser Val Ala Ser Thr Val Arg Phe Arg Val Asp Arg Lys Asp 
            180                 185                 190         


Asp Gly Gly Ile Ile Ile Cys Glu Ala Gln Asn Gln Ala Leu Pro Ser 
        195                 200                 205             


Gly His Ser Lys Gln Thr Gln Tyr Val Leu Asp Val Gln Tyr Ser Pro 
    210                 215                 220                 


Thr Ala Arg Ile His Ala Ser Gln Ala Val Val Arg Glu Gly Asp Thr 
225                 230                 235                 240 


Leu Val Leu Thr Cys Ala Val Thr Gly Asn Pro Arg Pro Asn Gln Ile 
                245                 250                 255     


Arg Trp Asn Arg Gly Asn Glu Ser Leu Pro Glu Arg Ala Glu Ala Val 
            260                 265                 270         


Gly Glu Thr Leu Thr Leu Pro Gly Leu Val Ser Ala Asp Asn Gly Thr 
        275                 280                 285             


Tyr Thr Cys Glu Ala Ser Asn Lys His Gly His Ala Arg Ala Leu Tyr 
    290                 295                 300                 


Val Leu Val Val Tyr Asp Pro Gly Ala Val Val Glu Ala Gln Thr Ser 
305                 310                 315                 320 


Val Pro Tyr Ala Ile Val Gly Gly Ile Leu Ala Leu Leu Val Phe Leu 
                325                 330                 335     


Ile Ile Cys Val Leu Val Gly Met Val Trp Cys Ser Val Arg Gln Lys 
            340                 345                 350         


Gly Ser Tyr Leu Thr His Glu Ala Ser Gly Leu Asp Glu Gln Gly Glu 
        355                 360                 365             


Ala Arg Glu Ala Phe Leu Asn Gly Ser Asp Gly His Lys Arg Lys Glu 
    370                 375                 380                 


Glu Phe Phe Ile 
385             


<210>  14
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  15
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 
1               5                   10                  15      


Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 
            20                  25                  30          


Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 
        35                  40                  45              


Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser 
    50                  55                  60                  


Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 
65                  70                  75                  80  


Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 
                85                  90                  95      


Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 
            100                 105                 110         


Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val 
    130                 135                 140                 


Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 
145                 150                 155                 160 


Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn 
                165                 170                 175     


Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro 
            180                 185                 190         


Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 
        195                 200                 205             


Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 
    210                 215                 220                 


Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 
225                 230                 235                 240 


Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His 
                245                 250                 255     


Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 
            260                 265                 270         


Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 
        275                 280                 285             


Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 
    290                 295                 300                 


Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 
305                 310                 315                 320 


Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr 
                325                 330                 335     


Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro 
            340                 345                 350         


Ala Pro Cys Phe Glu Val Glu 
        355                 


<210>  16
<211>  583
<212>  PRT
<213>  Mus musculus

<400>  16

Met Ala Ser Lys Val Ser Pro Ser Cys Arg Leu Val Phe Cys Leu Leu 
1               5                   10                  15      


Ile Ser Ala Ala Val Leu Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 
            20                  25                  30          


Ser Ala Tyr Gly Asp Thr Ile Val Met Pro Cys Arg Leu Asp Val Pro 
        35                  40                  45              


Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 
    50                  55                  60                  


Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 
65                  70                  75                  80  


Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Ser Leu Ser Glu Asn Tyr 
                85                  90                  95      


Thr Leu Ser Ile Ala Asn Ala Lys Ile Ser Asp Glu Lys Arg Phe Val 
            100                 105                 110         


Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Leu Val 
        115                 120                 125             


Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Asn Lys Ala Pro 
    130                 135                 140                 


Phe Leu Glu Thr Asp Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Arg 
145                 150                 155                 160 


Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 
                165                 170                 175     


Leu Gln Pro Val Glu Gly Glu Val Ala Ile Leu Phe Lys Lys Glu Ile 
            180                 185                 190         


Asp Pro Gly Thr Gln Leu Tyr Thr Val Thr Ser Ser Leu Glu Tyr Lys 
        195                 200                 205             


Thr Thr Arg Ser Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 
    210                 215                 220                 


Tyr Gly Pro Ser Gly Gln Lys Thr Ile Tyr Ser Glu Gln Glu Ile Phe 
225                 230                 235                 240 


Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 
                245                 250                 255     


Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Gln Cys Leu Gly 
            260                 265                 270         


Asn Gly Asn Pro Pro Pro Glu Glu Phe Met Phe Tyr Leu Pro Gly Gln 
        275                 280                 285             


Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 
    290                 295                 300                 


Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Arg Asn 
305                 310                 315                 320 


Met Ala Ala Ser Thr Thr Ile Thr Val His Tyr Leu Asp Leu Ser Leu 
                325                 330                 335     


Asn Pro Ser Gly Glu Val Thr Lys Gln Ile Gly Asp Thr Leu Pro Val 
            340                 345                 350         


Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 
        355                 360                 365             


Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 
    370                 375                 380                 


Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 
385                 390                 395                 400 


Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 
                405                 410                 415     


Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 
            420                 425                 430         


Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile His Trp Thr 
        435                 440                 445             


Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 
    450                 455                 460                 


Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 
465                 470                 475                 480 


Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 
                485                 490                 495     


Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 
            500                 505                 510         


Asp Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 
        515                 520                 525             


Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 
    530                 535                 540                 


Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 
545                 550                 555                 560 


Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 
                565                 570                 575     


Asn Asn His Lys Thr Glu Ala 
            580             


<210>  17
<211>  306
<212>  PRT
<213>  Gallus gallus

<400>  17

Met Glu Leu Leu Arg Gly Ala Ala Leu Leu Leu Leu Leu Cys Ala Ala 
1               5                   10                  15      


Ala Cys Ala Gln Asp Ser Cys Thr Cys Thr Lys Asn Lys Arg Val Thr 
            20                  25                  30          


Asn Cys Lys Leu Ile Asp Asn Val Cys His Cys Asn Ser Ile Gly Ser 
        35                  40                  45              


Ser Val Ser Val Asn Cys Glu Ile Leu Thr Ser Lys Cys Leu Leu Met 
    50                  55                  60                  


Lys Ala Glu Met Ala Asn Thr Lys Ser Gly Arg Arg Glu Lys Pro Lys 
65                  70                  75                  80  


Asp Ala Leu Gln Asp Thr Asp Gly Leu Tyr Asp Pro Glu Cys Gly Asn 
                85                  90                  95      


Asn Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly Thr Thr Cys Trp Cys 
            100                 105                 110         


Val Asn Thr Ala Gly Val Arg Arg Thr Asp Lys His Asp Thr Asp Leu 
        115                 120                 125             


Lys Cys Asn Gln Leu Val Arg Thr Thr Trp Ile Ile Ile Glu Met Arg 
    130                 135                 140                 


His Ala Glu Arg Lys Thr Pro Leu Asn Ala Glu Ser Leu Ile Arg Tyr 
145                 150                 155                 160 


Leu Lys Asp Thr Ile Thr Ser Arg Tyr Met Leu Asp Gly Arg Tyr Ile 
                165                 170                 175     


Ser Gly Val Val Tyr Glu Asn Pro Thr Ile Thr Ile Asp Leu Lys Gln 
            180                 185                 190         


Asn Ser Ser Asp Lys Thr Pro Gly Asp Val Asp Ile Thr Asp Val Ala 
        195                 200                 205             


Tyr Tyr Phe Glu Lys Asp Val Lys Asp Asp Ser Ile Phe Leu Asn Asn 
    210                 215                 220                 


Lys Leu Asn Met Asn Ile Asp Asn Glu Glu Leu Lys Phe Asp Asn Met 
225                 230                 235                 240 


Met Val Tyr Tyr Val Asp Glu Val Pro Pro Glu Phe Ser Met Lys Ser 
                245                 250                 255     


Leu Thr Ala Gly Val Ile Ala Val Ile Val Ile Val Val Leu Ala Ile 
            260                 265                 270         


Val Ala Gly Ile Ile Gly Leu Val Leu Ser Arg Arg Arg Lys Gly Lys 
        275                 280                 285             


Tyr Val Lys Ala Glu Met Lys Glu Met Asn Glu Met His Arg Gly Leu 
    290                 295                 300                 


Asn Ala 
305     


<210>  18
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asn Ser Phe Asn Tyr Thr Thr Pro Asp Tyr Gly His Tyr Asp Asp 
1               5                   10                  15      


Lys Asp Thr Leu Asp Leu Asn Thr Pro Val Asp Lys Thr Ser Asn Thr 
            20                  25                  30          


Leu Arg Val Pro Asp Ile Leu Ala Leu Val Ile Phe Ala Val Val Phe 
        35                  40                  45              


Leu Val Gly Val Leu Gly Asn Ala Leu Val Val Trp Val Thr Ala Phe 
    50                  55                  60                  


Glu Ala Lys Arg Thr Ile Asn Ala Ile Trp Phe Leu Asn Leu Ala Val 
65                  70                  75                  80  


Ala Asp Phe Leu Ser Cys Leu Ala Leu Pro Ile Leu Phe Thr Ser Ile 
                85                  90                  95      


Val Gln His His His Trp Pro Phe Gly Gly Ala Ala Cys Ser Ile Leu 
            100                 105                 110         


Pro Ser Leu Ile Leu Leu Asn Met Tyr Ala Ser Ile Leu Leu Leu Ala 
        115                 120                 125             


Thr Ile Ser Ala Asp Arg Phe Leu Leu Val Phe Lys Pro Ile Trp Cys 
    130                 135                 140                 


Gln Asn Phe Arg Gly Ala Gly Leu Ala Trp Ile Ala Cys Ala Val Ala 
145                 150                 155                 160 


Trp Gly Leu Ala Leu Leu Leu Thr Ile Pro Ser Phe Leu Tyr Arg Val 
                165                 170                 175     


Val Arg Glu Glu Tyr Phe Pro Pro Lys Val Leu Cys Gly Val Asp Tyr 
            180                 185                 190         


Ser His Asp Lys Arg Arg Glu Arg Ala Val Ala Ile Val Arg Leu Val 
        195                 200                 205             


Leu Gly Phe Leu Trp Pro Leu Leu Thr Leu Thr Ile Cys Tyr Thr Phe 
    210                 215                 220                 


Ile Leu Leu Arg Thr Trp Ser Arg Arg Ala Thr Arg Ser Thr Lys Thr 
225                 230                 235                 240 


Leu Lys Val Val Val Ala Val Val Ala Ser Phe Phe Ile Phe Trp Leu 
                245                 250                 255     


Pro Tyr Gln Val Thr Gly Ile Met Met Ser Phe Leu Glu Pro Ser Ser 
            260                 265                 270         


Pro Thr Phe Leu Leu Leu Asn Lys Leu Asp Ser Leu Cys Val Ser Phe 
        275                 280                 285             


Ala Tyr Ile Asn Cys Cys Ile Asn Pro Ile Ile Tyr Val Val Ala Gly 
    290                 295                 300                 


Gln Gly Phe Gln Gly Arg Leu Arg Lys Ser Leu Pro Ser Leu Leu Arg 
305                 310                 315                 320 


Asn Val Leu Thr Glu Glu Ser Val Val Arg Glu Ser Lys Ser Phe Thr 
                325                 330                 335     


Arg Ser Thr Val Asp Thr Met Ala Gln Lys Thr Gln Ala Val 
            340                 345                 350 


<210>  19
<211>  24
<212>  PRT
<213>  Synthetic

<400>  19

Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly Thr 
1               5                   10                  15      


Ala Ala Leu Leu Ile Gly Val Ile 
            20                  


<210>  20
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus

<400>  20

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  21
<211>  12
<212>  PRT
<213>  Synthetic

<400>  21

Gln Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln 
1               5                   10          


<210>  22
<211>  13
<212>  PRT
<213>  Synthetic

<400>  22

Met Gln Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln 
1               5                   10              


<210>  23
<211>  30
<212>  PRT
<213>  Synthetic

<400>  23

Leu Trp Gln Arg Arg Gln Arg Arg Gly Glu Glu Arg Lys Ala Pro Glu 
1               5                   10                  15      


Asn Gln Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln Ala 
            20                  25                  30  


<210>  24
<211>  29
<212>  PRT
<213>  Synthetic

<400>  24

Leu Trp Gln Arg Arg Gln Arg Arg Gly Glu Glu Arg Lys Ala Pro Glu 
1               5                   10                  15      


Asn Gln Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln 
            20                  25                  


<210>  25
<211>  12
<212>  PRT
<213>  Synthetic

<400>  25

Gln Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Arg 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Synthetic

<400>  26

Gln Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Lys 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Synthetic

<400>  27

Lys Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Synthetic

<400>  28

Lys Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Lys 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Synthetic

<400>  29

Lys Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Arg 
1               5                   10          


<210>  30
<211>  19
<212>  PRT
<213>  Synthetic

<400>  30

Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly Thr Ala Ala Leu Leu Ile 
1               5                   10                  15      


Gly Val Ile 
            


<210>  31
<211>  43
<212>  PRT
<213>  Synthetic

<400>  31

Leu Trp Gln Arg Arg Gln Arg Arg Gly Glu Glu Arg Lys Ala Pro Glu 
1               5                   10                  15      


Asn Gln Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln Ser Glu Glu 
            20                  25                  30          


Pro Glu Ala Gly Glu Ser Ser Thr Gly Gly Pro 
        35                  40              


