                         SEQUENCE LISTING

<110>  Georgia Tech Research Corporation
       Board of Regents, The University of Texas System
       Lieberman, Raquel L
       Hill, Shannon
       Patterson-Orazem, Athena
       Maynard, Jennifer  A
       Qerqez, Ahlam
       Yuan, Laura Azouz
 
<120>  Antibodies that Bind to Natively Folded Myocilin

<130>  064489.060PCT

<150>  62/776,799
<151>  2018-12-07

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Phe Phe Cys Ala Arg Cys Cys Ser Phe Gly Pro Glu Met Pro 
1               5                   10                  15      


Ala Val Gln Leu Leu Leu Leu Ala Cys Leu Val Trp Asp Val Gly Ala 
            20                  25                  30          


Arg Thr Ala Gln Leu Arg Lys Ala Asn Asp Gln Ser Gly Arg Cys Gln 
        35                  40                  45              


Tyr Thr Phe Ser Val Ala Ser Pro Asn Glu Ser Ser Cys Pro Glu Gln 
    50                  55                  60                  


Ser Gln Ala Met Ser Val Ile His Asn Leu Gln Arg Asp Ser Ser Thr 
65                  70                  75                  80  


Gln Arg Leu Asp Leu Glu Ala Thr Lys Ala Arg Leu Ser Ser Leu Glu 
                85                  90                  95      


Ser Leu Leu His Gln Leu Thr Leu Asp Gln Ala Ala Arg Pro Gln Glu 
            100                 105                 110         


Thr Gln Glu Gly Leu Gln Arg Glu Leu Gly Thr Leu Arg Arg Glu Arg 
        115                 120                 125             


Asp Gln Leu Glu Thr Gln Thr Arg Glu Leu Glu Thr Ala Tyr Ser Asn 
    130                 135                 140                 


Leu Leu Arg Asp Lys Ser Val Leu Glu Glu Glu Lys Lys Arg Leu Arg 
145                 150                 155                 160 


Gln Glu Asn Glu Asn Leu Ala Arg Arg Leu Glu Ser Ser Ser Gln Glu 
                165                 170                 175     


Val Ala Arg Leu Arg Arg Gly Gln Cys Pro Gln Thr Arg Asp Thr Ala 
            180                 185                 190         


Arg Ala Val Pro Pro Gly Ser Arg Glu Val Ser Thr Trp Asn Leu Asp 
        195                 200                 205             


Thr Leu Ala Phe Gln Glu Leu Lys Ser Glu Leu Thr Glu Val Pro Ala 
    210                 215                 220                 


Ser Arg Ile Leu Lys Glu Ser Pro Ser Gly Tyr Leu Arg Ser Gly Glu 
225                 230                 235                 240 


Gly Asp Thr Gly Cys Gly Glu Leu Val Trp Val Gly Glu Pro Leu Thr 
                245                 250                 255     


Leu Arg Thr Ala Glu Thr Ile Thr Gly Lys Tyr Gly Val Trp Met Arg 
            260                 265                 270         


Asp Pro Lys Pro Thr Tyr Pro Tyr Thr Gln Glu Thr Thr Trp Arg Ile 
        275                 280                 285             


Asp Thr Val Gly Thr Asp Val Arg Gln Val Phe Glu Tyr Asp Leu Ile 
    290                 295                 300                 


Ser Gln Phe Met Gln Gly Tyr Pro Ser Lys Val His Ile Leu Pro Arg 
305                 310                 315                 320 


Pro Leu Glu Ser Thr Gly Ala Val Val Tyr Ser Gly Ser Leu Tyr Phe 
                325                 330                 335     


Gln Gly Ala Glu Ser Arg Thr Val Ile Arg Tyr Glu Leu Asn Thr Glu 
            340                 345                 350         


Thr Val Lys Ala Glu Lys Glu Ile Pro Gly Ala Gly Tyr His Gly Gln 
        355                 360                 365             


Phe Pro Tyr Ser Trp Gly Gly Tyr Thr Asp Ile Asp Leu Ala Val Asp 
    370                 375                 380                 


Glu Ala Gly Leu Trp Val Ile Tyr Ser Thr Asp Glu Ala Lys Gly Ala 
385                 390                 395                 400 


Ile Val Leu Ser Lys Leu Asn Pro Glu Asn Leu Glu Leu Glu Gln Thr 
                405                 410                 415     


Trp Glu Thr Asn Ile Arg Lys Gln Ser Val Ala Asn Ala Phe Ile Ile 
            420                 425                 430         


Cys Gly Thr Leu Tyr Thr Val Ser Ser Tyr Thr Ser Ala Asp Ala Thr 
        435                 440                 445             


Val Asn Phe Ala Tyr Asp Thr Gly Thr Gly Ile Ser Lys Thr Leu Thr 
    450                 455                 460                 


Ile Pro Phe Lys Asn Arg Tyr Lys Tyr Ser Ser Met Ile Asp Tyr Asn 
465                 470                 475                 480 


Pro Leu Glu Lys Lys Leu Phe Ala Trp Asp Asn Leu Asn Met Val Thr 
                485                 490                 495     


Tyr Asp Ile Lys Leu Ser Lys Met 
            500                 


<210>  2
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Thr Ala Gln Leu Arg Lys Ala Asn Asp Gln Ser Gly Arg Cys Gln 
1               5                   10                  15      


Tyr Thr Phe Ser Val Ala Ser Pro Asn Glu Ser Ser Cys Pro Glu Gln 
            20                  25                  30          


Ser Gln Ala Met Ser Val Ile His Asn Leu Gln Arg Asp Ser Ser Thr 
        35                  40                  45              


Gln Arg Leu Asp Leu Glu Ala Thr Lys Ala Arg Leu Ser Ser Leu Glu 
    50                  55                  60                  


Ser Leu Leu His Gln Leu Thr Leu Asp Gln Ala Ala Arg Pro Gln Glu 
65                  70                  75                  80  


Thr Gln Glu Gly Leu Gln Arg Glu Leu Gly Thr Leu Arg Arg Glu Arg 
                85                  90                  95      


Asp Gln Leu Glu Thr Gln Thr Arg Glu Leu Glu Thr Ala Tyr Ser Asn 
            100                 105                 110         


Leu Leu Arg Asp Lys Ser Val Leu Glu Glu Glu Lys Lys Arg Leu Arg 
        115                 120                 125             


Gln Glu Asn Glu Asn Leu Ala Arg Arg Leu Glu Ser Ser Ser Gln Glu 
    130                 135                 140                 


Val Ala Arg Leu Arg Arg Gly Gln Cys Pro Gln Thr Arg Asp Thr Ala 
145                 150                 155                 160 


Arg Ala Val Pro Pro Gly Ser Arg Glu Val Ser Thr Trp Asn Leu Asp 
                165                 170                 175     


Thr Leu Ala Phe Gln Glu Leu Lys Ser Glu Leu Thr Glu Val Pro Ala 
            180                 185                 190         


Ser Arg 
        


<210>  3
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Gln Arg Asp Ser Ser Thr Gln Arg Leu Asp Leu Glu Ala Thr Lys 
1               5                   10                  15      


Ala Arg Leu Ser Ser Leu Glu Ser Leu Leu His Gln Leu Thr Leu Asp 
            20                  25                  30          


Gln Ala Ala Arg Pro Gln Glu Thr Gln Glu Gly Leu Gln Arg Glu Leu 
        35                  40                  45              


Gly Thr Leu Arg Arg Glu Arg Asp Gln Leu Glu Thr Gln Thr Arg Glu 
    50                  55                  60                  


Leu Glu Thr Ala Tyr Ser Asn Leu Leu Arg Asp Lys Ser Val Leu Glu 
65                  70                  75                  80  


Glu Glu Lys Lys Arg Leu Arg Gln Glu Asn Glu Asn Leu Ala Arg Arg 
                85                  90                  95      


Leu Glu Ser Ser Ser Gln Glu Val Ala Arg Leu Arg Arg Gly Gln 
            100                 105                 110     


<210>  4
<211>  490
<212>  PRT
<213>  Mus musculus

<400>  4

Met Pro Ala Leu His Leu Leu Phe Leu Ala Cys Leu Val Trp Gly Met 
1               5                   10                  15      


Gly Ala Arg Thr Ala Gln Phe Arg Lys Ala Asn Asp Arg Ser Gly Arg 
            20                  25                  30          


Cys Gln Tyr Thr Phe Thr Val Ala Ser Pro Asn Glu Ser Ser Cys Pro 
        35                  40                  45              


Arg Glu Asp Gln Ala Met Ser Ala Ile Gln Asp Leu Gln Arg Asp Ser 
    50                  55                  60                  


Ser Ile Gln His Ala Asp Leu Glu Ser Thr Lys Ala Arg Val Arg Ser 
65                  70                  75                  80  


Leu Glu Ser Leu Leu His Gln Met Thr Leu Gly Arg Val Thr Gly Thr 
                85                  90                  95      


Gln Glu Ala Gln Glu Gly Leu Gln Gly Gln Leu Gly Ala Leu Arg Arg 
            100                 105                 110         


Glu Arg Asp Gln Leu Glu Thr Gln Thr Arg Asp Leu Glu Ala Ala Tyr 
        115                 120                 125             


Asn Asn Leu Leu Arg Asp Lys Ser Ala Leu Glu Glu Glu Lys Arg Gln 
    130                 135                 140                 


Leu Glu Gln Glu Asn Glu Asp Leu Ala Arg Arg Leu Glu Ser Ser Ser 
145                 150                 155                 160 


Glu Glu Val Thr Arg Leu Arg Arg Gly Gln Cys Pro Ser Thr Gln Tyr 
                165                 170                 175     


Pro Ser Gln Asp Met Leu Pro Gly Ser Arg Glu Val Ser Gln Trp Asn 
            180                 185                 190         


Leu Asp Thr Leu Ala Phe Gln Glu Leu Lys Ser Glu Leu Thr Glu Val 
        195                 200                 205             


Pro Ala Ser Gln Ile Leu Lys Glu Asn Pro Ser Gly Arg Pro Arg Ser 
    210                 215                 220                 


Lys Glu Gly Asp Lys Gly Cys Gly Ala Leu Val Trp Val Gly Glu Pro 
225                 230                 235                 240 


Val Thr Leu Arg Thr Ala Glu Thr Ile Ala Gly Lys Tyr Gly Val Trp 
                245                 250                 255     


Met Arg Asp Pro Lys Pro Thr His Pro Tyr Thr Gln Glu Ser Thr Trp 
            260                 265                 270         


Arg Ile Asp Thr Val Gly Thr Glu Ile Arg Gln Val Phe Glu Tyr Ser 
        275                 280                 285             


Gln Ile Ser Gln Phe Glu Gln Gly Tyr Pro Ser Lys Val His Val Leu 
    290                 295                 300                 


Pro Arg Ala Leu Glu Ser Thr Gly Ala Val Val Tyr Ala Gly Ser Leu 
305                 310                 315                 320 


Tyr Phe Gln Gly Ala Glu Ser Arg Thr Val Val Arg Tyr Glu Leu Asp 
                325                 330                 335     


Thr Glu Thr Val Lys Ala Glu Lys Glu Ile Pro Gly Ala Gly Tyr His 
            340                 345                 350         


Gly His Phe Pro Tyr Ala Trp Gly Gly Tyr Thr Asp Ile Asp Leu Ala 
        355                 360                 365             


Val Asp Glu Ser Gly Leu Trp Val Ile Tyr Ser Thr Glu Glu Ala Lys 
    370                 375                 380                 


Gly Ala Ile Val Leu Ser Lys Leu Asn Pro Ala Asn Leu Glu Leu Glu 
385                 390                 395                 400 


Arg Thr Trp Glu Thr Asn Ile Arg Lys Gln Ser Val Ala Asn Ala Phe 
                405                 410                 415     


Val Ile Cys Gly Ile Leu Tyr Thr Val Ser Ser Tyr Ser Ser Ala His 
            420                 425                 430         


Ala Thr Val Asn Phe Ala Tyr Asp Thr Lys Thr Gly Thr Ser Lys Thr 
        435                 440                 445             


Leu Thr Ile Pro Phe Thr Asn Arg Tyr Lys Tyr Ser Ser Met Ile Asp 
    450                 455                 460                 


Tyr Asn Pro Leu Glu Arg Lys Leu Phe Ala Trp Asp Asn Phe Asn Met 
465                 470                 475                 480 


Val Thr Tyr Asp Ile Lys Leu Leu Glu Met 
                485                 490 


<210>  5
<211>  194
<212>  PRT
<213>  Mus musculus

<400>  5

Arg Thr Ala Gln Phe Arg Lys Ala Asn Asp Arg Ser Gly Arg Cys Gln 
1               5                   10                  15      


Tyr Thr Phe Thr Val Ala Ser Pro Asn Glu Ser Ser Cys Pro Arg Glu 
            20                  25                  30          


Asp Gln Ala Met Ser Ala Ile Gln Asp Leu Gln Arg Asp Ser Ser Ile 
        35                  40                  45              


Gln His Ala Asp Leu Glu Ser Thr Lys Ala Arg Val Arg Ser Leu Glu 
    50                  55                  60                  


Ser Leu Leu His Gln Met Thr Leu Gly Arg Val Thr Gly Thr Gln Glu 
65                  70                  75                  80  


Ala Gln Glu Gly Leu Gln Gly Gln Leu Gly Ala Leu Arg Arg Glu Arg 
                85                  90                  95      


Asp Gln Leu Glu Thr Gln Thr Arg Asp Leu Glu Ala Ala Tyr Asn Asn 
            100                 105                 110         


Leu Leu Arg Asp Lys Ser Ala Leu Glu Glu Glu Lys Arg Gln Leu Glu 
        115                 120                 125             


Gln Glu Asn Glu Asp Leu Ala Arg Arg Leu Glu Ser Ser Ser Glu Glu 
    130                 135                 140                 


Val Thr Arg Leu Arg Arg Gly Gln Cys Pro Ser Thr Gln Tyr Pro Ser 
145                 150                 155                 160 


Gln Asp Met Leu Pro Gly Ser Arg Glu Val Ser Gln Trp Asn Leu Asp 
                165                 170                 175     


Thr Leu Ala Phe Gln Glu Leu Lys Ser Glu Leu Thr Glu Val Pro Ala 
            180                 185                 190         


Ser Gln 
        


<210>  6
<211>  102
<212>  PRT
<213>  Mus musculus

<400>  6

Ala Asp Leu Glu Ser Thr Lys Ala Arg Val Arg Ser Leu Glu Ser Leu 
1               5                   10                  15      


Leu His Gln Met Thr Leu Gly Arg Val Thr Gly Thr Gln Glu Ala Gln 
            20                  25                  30          


Glu Gly Leu Gln Gly Gln Leu Gly Ala Leu Arg Arg Glu Arg Asp Gln 
        35                  40                  45              


Leu Glu Thr Gln Thr Arg Asp Leu Glu Ala Ala Tyr Asn Asn Leu Leu 
    50                  55                  60                  


Arg Asp Lys Ser Ala Leu Glu Glu Glu Lys Arg Gln Leu Glu Gln Glu 
65                  70                  75                  80  


Asn Glu Asp Leu Ala Arg Arg Leu Glu Ser Ser Ser Glu Glu Val Thr 
                85                  90                  95      


Arg Leu Arg Arg Gly Gln 
            100         


<210>  7
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of monoclonal antibody 2A4

<400>  7

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Ser Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region for monoclonal antibody 2A4

<400>  8

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Pro Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR1

<400>  9

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR2

<400>  10

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3

<400>  11

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr Phe 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Heavy chain CDR1

<400>  12

Gly Phe Asn Ile Lys Asp Tyr Tyr Met His 
1               5                   10  


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Heavy chain CDR2

<400>  13

Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  14

Gln Gln Tyr Met Tyr Leu Pro Ile Thr 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  15

Gln Gln Tyr Phe Ala Leu Pro Ile Thr 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  16

Gln Gln Tyr Asp Val Val Pro Arg Thr 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  17

Gln Gln Tyr Ala Phe Phe Pro Leu Thr 
1               5                   


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Heavy chain CDR2 variant

<400>  18

Trp Ile Asp Pro Ala Asn Gly Ser Thr Tyr Tyr Ser Asp Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  19

Gln Gln Tyr Lys Trp Leu Pro Leu Thr 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  20

Gln Gln Tyr Asn Glu Leu Pro Ile Thr 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  21

Gln Gln Tyr Asp Phe Phe Pro Leu Thr 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  22

Gln Gln Tyr Thr Phe Leu Pro Ile Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  23

Gln Gln Tyr Ser Ala Leu Pro Leu Thr 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  24

Gln Gln Tyr Asp Ala Val Pro Leu Thr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  25

Gln Gln Tyr Ser Val Leu Pro Ile Thr 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  26

Gln Gln Tyr Asp Val Leu Pro Leu Thr 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  27

Gln Gln Tyr Glu Phe Phe Pro Arg Thr 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  28

Gln Gln Tyr Phe Leu Leu Pro Ile Thr 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  29

Gln Gln Tyr Gln Glu Val Pro Arg Thr 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  30

Gln Gln Tyr Ala Ser Val Pro Leu Thr 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  31

Gln Gln Tyr Gly Tyr Leu Pro Leu Thr 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  32

Gln Gln Tyr Ala Phe Leu Pro Val Thr 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  33

Gln Gln Tyr Asp Arg Val Pro Leu Thr 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  34

Gln Gln Tyr Ala Phe Leu Pro Leu Thr 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  35

Gln Gln Tyr Arg Phe Leu Pro Ile Thr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  36

Gln Gln Tyr Asn Ser Leu Pro Leu Thr 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  37

Gln Gln Tyr Met Tyr Leu Pro Leu Thr 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  38

Gln Gln Tyr Ala Ser Leu Pro Ile Thr 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  39

Gln Gln Tyr Asp Val Leu Pro Ile Thr 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  40

Gln Gln Tyr Ala Phe Leu Pro Ile Thr 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Light chain CDR3 variant

<400>  41

Gln Gln Tyr Met Phe Leu Pro Leu Thr 
1               5                   


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Heavy chain CDR2 variant

<400>  42

Trp Ile Asp Pro Asp Asp Gly Ser Thr Tyr Tyr Ser Pro Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Heavy chain CDR2 variant

<400>  43

Trp Ile Asp Pro Ser Asn Gly Asp Thr Tyr Tyr Ala His Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Heavy chain CDR2 variant

<400>  44

Trp Ile Asp Pro Ala Asn Gly Ser Thr Tyr Tyr Ala Asp Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 2A4 Heavy chain CDR2 variant

<400>  45

Trp Ile Asp Pro Glu Asp Gly Ser Thr Tyr Tyr Ser Asp Arg Phe Lys 
1               5                   10                  15      


Gly 
    


