                         SEQUENCE LISTING

<110>  Genome Protection, Inc.
       Mett, Vadim
       Gudkov, Andrei
 
<120>  ENGINEERED FLAGELLIN VARIANTS AND USES

<130>  GPI-020PC/112491-5020

<150>  US 62/776,507
<151>  2018-12-07

<160>  40    
<170>  PatentIn version 3.5

<210>  1
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  1

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  2
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  2

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ala Ala Asn Arg Ala Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Asp Gln Ala Gly Thr Ser Thr Leu 
    210                 215                 220                 


Ala Gln Leu Val Pro Arg Gly Ser His His His His His His Gly 
225                 230                 235                 


<210>  3
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  3

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln 
        35                  40                  45              


Asn Asn Leu Asn Lys Ser Gln Ser Ser Leu Ser Ser Ala Ile Glu Arg 
    50                  55                  60                  


Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln 
                85                  90                  95      


Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu 
            100                 105                 110         


Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu 
        115                 120                 125             


Ser Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser 
    130                 135                 140                 


Ile Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser 
145                 150                 155                 160 


Asn Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln 
                165                 170                 175     


Met Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp 
            180                 185                 190         


Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val 
        195                 200                 205             


Asn Ser Pro Gly Ile Ser Gly Gly Gly Gly Gly Ile Leu Asp Ser Met 
    210                 215                 220                 


Gly Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala 
225                 230                 235                 240 


Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val 
                245                 250                 255     


Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr 
            260                 265                 270         


Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile 
        275                 280                 285             


Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Lys Ala Gln 
    290                 295                 300                 


Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val 
305                 310                 315                 320 


Pro Gln Asn Val Leu Ser Leu Leu Arg 
                325                 


<210>  4
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  4

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ser Leu Ser Ser Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
                85                  90                  95      


Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser Ile 
            100                 105                 110         


Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Asn 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln Met 
    130                 135                 140                 


Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp Leu 
145                 150                 155                 160 


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
                165                 170                 175     


Gly Pro Lys Glu Ala Thr Val Gly Asp Leu Lys Ser Ser Phe Lys Asn 
            180                 185                 190         


Val Thr Gly Tyr Asp Thr Tyr Ala Ala Gly Ala Asp Lys Tyr Arg Val 
        195                 200                 205             


Asp Ile Asn Ser Gly Ala Val Val Thr Asp Ala Ala Ala Pro Asp Lys 
    210                 215                 220                 


Val Tyr Val Asn Ala Ala Asn Gly Gln Leu Thr Thr Asp Asp Ala Glu 
225                 230                 235                 240 


Asn Asn Thr Ala Val Asp Leu Phe Lys Thr Thr Lys Ser Thr Ala Gly 
                245                 250                 255     


Thr Ala Glu Ala Lys Ala Ile Ala Gly Ala Ile Lys Gly Gly Lys Glu 
            260                 265                 270         


Gly Asp Thr Phe Asp Tyr Lys Gly Val Thr Phe Thr Ile Asp Thr Lys 
        275                 280                 285             


Thr Gly Asp Asp Gly Asn Gly Lys Val Ser Thr Thr Ile Asn Gly Glu 
    290                 295                 300                 


Lys Val Thr Leu Thr Val Ala Asp Ile Ala Thr Gly Ala Ala Asp Val 
305                 310                 315                 320 


Asn Ala Ala Thr Leu Gln Ser Ser Lys Asn Val Tyr Thr Ser Val Val 
                325                 330                 335     


Asn Gly Gln Phe Thr Phe Asp Asp Lys Thr Lys Asn Glu Ser Ala Lys 
            340                 345                 350         


Leu Ser Asp Leu Glu Ala Asn Asn Ala Val Lys Gly Glu Ser Lys Ile 
        355                 360                 365             


Thr Val Asn Gly Ala Glu Tyr Thr Ala Asn Ala Thr Gly Asp Lys Ile 
    370                 375                 380                 


Thr Leu Ala Gly Lys Thr Met Phe Ile Asp Lys Thr Ala Ser Gly Val 
385                 390                 395                 400 


Ser Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala 
                405                 410                 415     


Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val 
            420                 425                 430         


Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr 
        435                 440                 445             


Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile 
    450                 455                 460                 


Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Lys Ala Gln 
465                 470                 475                 480 


Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val 
                485                 490                 495     


Pro Gln Asn Val Leu Ser Leu Leu Arg 
            500                 505 


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  5

His His His His His His 
1               5       


<210>  6
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  6

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Leu Val Pro Arg Gly Ser His His His His His His Gly 
225                 230                 235                 


<210>  7
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  7

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Ala Asp Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  8
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  8

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Ser Asp Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  9
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  9

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Thr Asp Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  10
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  10

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Asp Asp Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  11
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  11

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ala Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  12
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  12

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Ala Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  13
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  13

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Asp Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  14
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  14

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Glu Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  15
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  15

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Thr Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  16
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  16

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Glu Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  17
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  17

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ala Asp Gln Gln Ala Gly Thr Ser Thr Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  18
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  18

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ala Asp Gln Gln Ala Gly Thr Ser Val Asp 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  19
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  19

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ala Asn Gln Gln Ala Gly Thr Ser Thr Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  20
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  20

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ala Asn Gln Gln Ala Gly Thr Ser Val Asp 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  21
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  21

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ala Ser Gln Gln Ala Gly Thr Ser Thr Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  22
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  22

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ala Ser Gln Gln Ala Gly Thr Ser Val Asp 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  23
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  23

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ala Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  24
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  24

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Ala Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  25
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  25

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Thr Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  26
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  26

Met His His His His His His Ser Gly Leu Arg Ile Asn Ser Ala Lys 
1               5                   10                  15      


Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile 
            20                  25                  30          


Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile 
        35                  40                  45              


Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln 
    50                  55                  60                  


Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala Gly Ala Asn Ala Asp 
65                  70                  75                  80  


Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala Ala Val Lys Val Leu 
            100                 105                 110         


Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly Ala Asn Asp Gly Ala 
        115                 120                 125             


Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu 
    130                 135                 140                 


Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala 
145                 150                 155                 160 


Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu 
                165                 170                 175     


Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn 
            180                 185                 190         


Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp 
        195                 200                 205             


Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala Gln Ile Asp Gln Gln 
    210                 215                 220                 


Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val 
225                 230                 235                 240 


Leu Ser Leu Leu Arg 
                245 


<210>  27
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  27

Met His His His His His His Ser Gly Leu Arg Ile Asn Ser Ala Lys 
1               5                   10                  15      


Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile 
            20                  25                  30          


Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile 
        35                  40                  45              


Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln 
    50                  55                  60                  


Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala Gly Ala Asn Ala Asp 
65                  70                  75                  80  


Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala Ala Val Lys Val Leu 
            100                 105                 110         


Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly Ala Asn Asp Gly Ala 
        115                 120                 125             


Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu 
    130                 135                 140                 


Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala 
145                 150                 155                 160 


Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu 
                165                 170                 175     


Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn 
            180                 185                 190         


Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp 
        195                 200                 205             


Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala Gln Ile His Gln Gln 
    210                 215                 220                 


Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val 
225                 230                 235                 240 


Leu Ser Leu Leu Arg 
                245 


<210>  28
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  28

Met His His His His His His Ser Gly Leu Arg Ile Asn Ser Ala Lys 
1               5                   10                  15      


Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile 
            20                  25                  30          


Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile 
        35                  40                  45              


Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln 
    50                  55                  60                  


Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala Gly Ala Asn Ala Asp 
65                  70                  75                  80  


Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala Ala Val Lys Val Leu 
            100                 105                 110         


Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly Ala Asn Asp Gly Ala 
        115                 120                 125             


Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu 
    130                 135                 140                 


Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala 
145                 150                 155                 160 


Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu 
                165                 170                 175     


Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn 
            180                 185                 190         


Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp 
        195                 200                 205             


Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala Gln Ile Leu Asp Gln 
    210                 215                 220                 


Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val 
225                 230                 235                 240 


Leu Ser Leu Leu Arg 
                245 


<210>  29
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  29

Met His His His His His His Ser Gly Leu Arg Ile Asn Ser Ala Lys 
1               5                   10                  15      


Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile 
            20                  25                  30          


Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile 
        35                  40                  45              


Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln 
    50                  55                  60                  


Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala Gly Ala Asn Ala Asp 
65                  70                  75                  80  


Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala Ala Val Lys Val Leu 
            100                 105                 110         


Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly Ala Asn Asp Gly Ala 
        115                 120                 125             


Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu 
    130                 135                 140                 


Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala 
145                 150                 155                 160 


Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu 
                165                 170                 175     


Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn 
            180                 185                 190         


Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp 
        195                 200                 205             


Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala Gln Ile Leu Gln Gln 
    210                 215                 220                 


Ala Gly Asp Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val 
225                 230                 235                 240 


Leu Ser Leu Leu Arg 
                245 


<210>  30
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  30

Met His His His His His His Ser Gly Leu Arg Ile Asn Ser Ala Lys 
1               5                   10                  15      


Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile 
            20                  25                  30          


Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile 
        35                  40                  45              


Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln 
    50                  55                  60                  


Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala Gly Ala Asn Ala Asp 
65                  70                  75                  80  


Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala Ala Val Lys Val Leu 
            100                 105                 110         


Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly Ala Asn Asp Gly Ala 
        115                 120                 125             


Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu 
    130                 135                 140                 


Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala 
145                 150                 155                 160 


Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu 
                165                 170                 175     


Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn 
            180                 185                 190         


Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp 
        195                 200                 205             


Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala Gln Lys Asp Gln Gln 
    210                 215                 220                 


Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val 
225                 230                 235                 240 


Leu Ser Leu Leu Arg 
                245 


<210>  31
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  31

Met His His His His His His Ser Gly Leu Arg Ile Asn Ser Ala Lys 
1               5                   10                  15      


Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile 
            20                  25                  30          


Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile 
        35                  40                  45              


Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln 
    50                  55                  60                  


Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala Gly Ala Asn Ala Asp 
65                  70                  75                  80  


Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala Ala Val Lys Val Leu 
            100                 105                 110         


Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly Ala Asn Asp Gly Ala 
        115                 120                 125             


Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu 
    130                 135                 140                 


Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala 
145                 150                 155                 160 


Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu 
                165                 170                 175     


Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn 
            180                 185                 190         


Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp 
        195                 200                 205             


Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala Gln Ile Leu Asp Gln 
    210                 215                 220                 


Ala Gly Asp Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val 
225                 230                 235                 240 


Leu Ser Leu Leu Arg 
                245 


<210>  32
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  32

Met His His His His His His Ser Gly Leu Arg Ile Asn Ser Ala Lys 
1               5                   10                  15      


Asp Asp Ala Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile 
            20                  25                  30          


Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile 
        35                  40                  45              


Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln 
    50                  55                  60                  


Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala Gly Ala Asn Ala Asp 
65                  70                  75                  80  


Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala Ala Val Lys Val Leu 
            100                 105                 110         


Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly Ala Asn Asp Gly Ala 
        115                 120                 125             


Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu 
    130                 135                 140                 


Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala 
145                 150                 155                 160 


Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu 
                165                 170                 175     


Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn 
            180                 185                 190         


Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp 
        195                 200                 205             


Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala Gln Ile Leu Gln Gln 
    210                 215                 220                 


Ala Gly Asp Ser Val Leu Ala Gln Gly 
225                 230             


<210>  33
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  33

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Ala Ser Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  34
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  34

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Thr Ala Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  35
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  35

Met His His His His His His Ser Gly Leu Arg Ile Asn Ser Ala Lys 
1               5                   10                  15      


Asp Asp Ala Ala Gly Gln Ala Ala Ala Asn Arg Ala Thr Ser Asn Ile 
            20                  25                  30          


Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile 
        35                  40                  45              


Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln 
    50                  55                  60                  


Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala Gly Ala Asn Ala Asp 
65                  70                  75                  80  


Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala Ala Val Lys Val Leu 
            100                 105                 110         


Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly Ala Asn Asp Gly Ala 
        115                 120                 125             


Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu 
    130                 135                 140                 


Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala 
145                 150                 155                 160 


Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu 
                165                 170                 175     


Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn 
            180                 185                 190         


Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp 
        195                 200                 205             


Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala Gln Ile Leu Asp Gln 
    210                 215                 220                 


Ala Gly Thr Ser Thr Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val 
225                 230                 235                 240 


Leu Ser Leu Leu Arg 
                245 


<210>  36
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  36

Met His His His His His His Leu Val Pro Arg Gly Ser Gly Leu Arg 
1               5                   10                  15      


Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ala Ala Asn Arg 
            20                  25                  30          


Ala Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala 
        35                  40                  45              


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
    50                  55                  60                  


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala 
65                  70                  75                  80  


Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln 
                85                  90                  95      


Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala 
            100                 105                 110         


Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly 
        115                 120                 125             


Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val 
    130                 135                 140                 


Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr 
145                 150                 155                 160 


Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala 
                165                 170                 175     


Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile 
            180                 185                 190         


Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg 
        195                 200                 205             


Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala 
    210                 215                 220                 


Gln Ile Leu Asp Gln Ala Gly Thr Ser Thr Leu Ala Gln Ala Asn Gln 
225                 230                 235                 240 


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
                245                 250 


<210>  37
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  37

Met Leu Val Pro Arg Gly Ser His His His His His His Ser Gly Leu 
1               5                   10                  15      


Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ala Ala Asn 
            20                  25                  30          


Arg Ala Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala 
        35                  40                  45              


Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu 
    50                  55                  60                  


Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser Val Gln Ala Thr 
65                  70                  75                  80  


Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile 
                85                  90                  95      


Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln Gln Thr Gln Ala 
            100                 105                 110         


Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met Ala Ile Gln Val 
        115                 120                 125             


Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp 
    130                 135                 140                 


Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn Ser Pro Gly Ser 
145                 150                 155                 160 


Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp 
                165                 170                 175     


Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala 
            180                 185                 190         


Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser 
        195                 200                 205             


Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Gln Met Ser Lys 
    210                 215                 220                 


Ala Gln Ile Leu Asp Gln Ala Gly Thr Ser Thr Leu Ala Gln Ala Asn 
225                 230                 235                 240 


Gln Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
                245                 250     


<210>  38
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  38

Met His His His His His His Gly Ser Pro Arg Gly Ser Gly Leu Arg 
1               5                   10                  15      


Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ala Ala Asn Arg 
            20                  25                  30          


Ala Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala 
        35                  40                  45              


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
    50                  55                  60                  


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala 
65                  70                  75                  80  


Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln 
                85                  90                  95      


Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala 
            100                 105                 110         


Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly 
        115                 120                 125             


Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val 
    130                 135                 140                 


Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr 
145                 150                 155                 160 


Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala 
                165                 170                 175     


Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile 
            180                 185                 190         


Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg 
        195                 200                 205             


Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala 
    210                 215                 220                 


Gln Ile Leu Asp Gln Ala Gly Thr Ser Thr Leu Ala Gln Ala Asn Gln 
225                 230                 235                 240 


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
                245                 250 


<210>  39
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  39

Met His His His His His His Ala Val Pro Arg Gly Ser Gly Leu Arg 
1               5                   10                  15      


Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ala Ala Asn Arg 
            20                  25                  30          


Ala Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala 
        35                  40                  45              


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
    50                  55                  60                  


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala 
65                  70                  75                  80  


Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln 
                85                  90                  95      


Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala 
            100                 105                 110         


Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly 
        115                 120                 125             


Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val 
    130                 135                 140                 


Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr 
145                 150                 155                 160 


Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala 
                165                 170                 175     


Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile 
            180                 185                 190         


Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg 
        195                 200                 205             


Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala 
    210                 215                 220                 


Gln Ile Leu Asp Gln Ala Gly Thr Ser Thr Leu Ala Gln Ala Asn Gln 
225                 230                 235                 240 


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
                245                 250 


<210>  40
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide.

<400>  40

Met His His His His His His Ala Ala Pro Arg Gly Ser Gly Leu Arg 
1               5                   10                  15      


Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln Ala Ala Ala Asn Arg 
            20                  25                  30          


Ala Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala Ala 
        35                  40                  45              


Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu Ile 
    50                  55                  60                  


Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser Val Gln Ala Thr Ala 
65                  70                  75                  80  


Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile Gln Ala Glu Ile Gln 
                85                  90                  95      


Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln Gln Thr Gln Ala Ala 
            100                 105                 110         


Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met Ala Ile Gln Val Gly 
        115                 120                 125             


Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu Gln Lys Ile Asp Val 
    130                 135                 140                 


Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn Ser Pro Gly Ser Thr 
145                 150                 155                 160 


Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala 
                165                 170                 175     


Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile 
            180                 185                 190         


Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg 
        195                 200                 205             


Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Gln Met Ser Lys Ala 
    210                 215                 220                 


Gln Ile Leu Asp Gln Ala Gly Thr Ser Thr Leu Ala Gln Ala Asn Gln 
225                 230                 235                 240 


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
                245                 250 


