                         SEQUENCE LISTING

<110>  University of Virginia Patent Foundation
       Gaultier, Alban
       Rosen, Dorian A
 
<120>  COMPOSITIONS AND METHODS FOR REGULATING INFLAMMATION

<130>  3062/98 PCT

<150>  US 62/775,416
<151>  2018-12-05

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1672
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (91)..(762)

<400>  1
gtgggcagcc ggcgggctcc gaggccgtga gcgcaaagcc tcaggccccg gctccctcct       60

gagctgcgcc gtgccaggcc gcccgccggg atg cag tgg gcc gtg ggc cgg cgg       114
                                 Met Gln Trp Ala Val Gly Arg Arg          
                                 1               5                        

tgg gcg tgg gcc gcg ctg ctc ctg gct gtc gca gcg gtg ctg acc cag        162
Trp Ala Trp Ala Ala Leu Leu Leu Ala Val Ala Ala Val Leu Thr Gln           
    10                  15                  20                            

gtc gtc tgg ctc tgg ctg ggt acg cag agc ttc gtc ttc cag cgc gaa        210
Val Val Trp Leu Trp Leu Gly Thr Gln Ser Phe Val Phe Gln Arg Glu           
25                  30                  35                  40            

gag ata gcg cag ttg gcg cgg cag tac gct ggg ctg gac cac gag ctg        258
Glu Ile Ala Gln Leu Ala Arg Gln Tyr Ala Gly Leu Asp His Glu Leu           
                45                  50                  55                

gcc ttc tct cgt ctg atc gtg gag ctg cgg cgg ctg cac cca ggc cac        306
Ala Phe Ser Arg Leu Ile Val Glu Leu Arg Arg Leu His Pro Gly His           
            60                  65                  70                    

gtg ctg ccc gac gag gag ctg cag tgg gtg ttc gtg aat gcg ggt ggc        354
Val Leu Pro Asp Glu Glu Leu Gln Trp Val Phe Val Asn Ala Gly Gly           
        75                  80                  85                        

tgg atg ggc gcc atg tgc ctt ctg cac gcc tcg ctg tcc gag tat gtg        402
Trp Met Gly Ala Met Cys Leu Leu His Ala Ser Leu Ser Glu Tyr Val           
    90                  95                  100                           

ctg ctc ttc ggc acc gcc ttg ggc tcc cgc ggc cac tcg ggg cgc tac        450
Leu Leu Phe Gly Thr Ala Leu Gly Ser Arg Gly His Ser Gly Arg Tyr           
105                 110                 115                 120           

tgg gct gag atc tcg gat acc atc atc tct ggc acc ttc cac cag tgg        498
Trp Ala Glu Ile Ser Asp Thr Ile Ile Ser Gly Thr Phe His Gln Trp           
                125                 130                 135               

aga gag ggc acc acc aaa agt gag gtc ttc tac cca ggg gag acg gta        546
Arg Glu Gly Thr Thr Lys Ser Glu Val Phe Tyr Pro Gly Glu Thr Val           
            140                 145                 150                   

gta cac ggg cct ggt gag gca aca gct gtg gag tgg ggg cca aac aca        594
Val His Gly Pro Gly Glu Ala Thr Ala Val Glu Trp Gly Pro Asn Thr           
        155                 160                 165                       

tgg atg gtg gag tac ggc cgg ggc gtc atc cca tcc acc ctg gcc ttc        642
Trp Met Val Glu Tyr Gly Arg Gly Val Ile Pro Ser Thr Leu Ala Phe           
    170                 175                 180                           

gcg ctg gcc gac act gtc ttc agc acc cag gac ttc ctc acc ctc ttc        690
Ala Leu Ala Asp Thr Val Phe Ser Thr Gln Asp Phe Leu Thr Leu Phe           
185                 190                 195                 200           

tat act ctt cgc tcc tat gct cgg ggc ctc cgg ctt gag ctc acc acc        738
Tyr Thr Leu Arg Ser Tyr Ala Arg Gly Leu Arg Leu Glu Leu Thr Thr           
                205                 210                 215               

tac ctc ttt ggc cag gac cct tga ccagccaggc ctgaaggaag acctgcggat       792
Tyr Leu Phe Gly Gln Asp Pro                                               
            220                                                           

agacaggagc gggcaggccc gcacatatcc acttgctgga gcccatgttt acagacaggg      852

acatacacca tgcagatcct gagttcctgc tgtatgagca gggatatcca tgcttatgta      912

tccaaacaca gagacccatg ggaacaaatg agacacatat agatactgag acctgtgtgt      972

acagtaggac catgcactca cacccatctg gagagggagc ccccggtata ccaagggagc     1032

cagttgtgtt cagacacaca catcacagct tgactcacta actgaggcct ttccatagct     1092

ccacagcttc ccacctcctc cccaccaaac cggggttcta gagttaagga tgggggaggg     1152

tattatactg cctcagtctg actcctcaac ccagcagcaa tttgagggga tgagggggaa     1212

gaggagctgc cttttggagg cccccttcac ctgcagctat gatgcccttc cccttctccc     1272

ctgtcctcac catatgcctt atccccattc tactcccctg ctatgcaagt gcccctgtgg     1332

cttgtcccca accccctcag caacaaagct cagctgggga acgagagtaa tttgaagaat     1392

gcttgaagtc agcgtcttcc attccagaaa gacccccatt cttcctttgg gggtatgatg     1452

tggaagctgg tttcagccca ggacccacca ctgaggagag gatctagaca ggtgggccta     1512

attccaaggg gcccttcctg gcctggagaa ggccttttac acacacacaa cacatacaca     1572

cacacacaca cacacacata tcacagtttt cacacagccc ctgctgcatt ctctgtccat     1632

ctgtctgttt ctattaataa agatttgttg atctgttcca                           1672


<210>  2
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Trp Ala Val Gly Arg Arg Trp Ala Trp Ala Ala Leu Leu Leu 
1               5                   10                  15      


Ala Val Ala Ala Val Leu Thr Gln Val Val Trp Leu Trp Leu Gly Thr 
            20                  25                  30          


Gln Ser Phe Val Phe Gln Arg Glu Glu Ile Ala Gln Leu Ala Arg Gln 
        35                  40                  45              


Tyr Ala Gly Leu Asp His Glu Leu Ala Phe Ser Arg Leu Ile Val Glu 
    50                  55                  60                  


Leu Arg Arg Leu His Pro Gly His Val Leu Pro Asp Glu Glu Leu Gln 
65                  70                  75                  80  


Trp Val Phe Val Asn Ala Gly Gly Trp Met Gly Ala Met Cys Leu Leu 
                85                  90                  95      


His Ala Ser Leu Ser Glu Tyr Val Leu Leu Phe Gly Thr Ala Leu Gly 
            100                 105                 110         


Ser Arg Gly His Ser Gly Arg Tyr Trp Ala Glu Ile Ser Asp Thr Ile 
        115                 120                 125             


Ile Ser Gly Thr Phe His Gln Trp Arg Glu Gly Thr Thr Lys Ser Glu 
    130                 135                 140                 


Val Phe Tyr Pro Gly Glu Thr Val Val His Gly Pro Gly Glu Ala Thr 
145                 150                 155                 160 


Ala Val Glu Trp Gly Pro Asn Thr Trp Met Val Glu Tyr Gly Arg Gly 
                165                 170                 175     


Val Ile Pro Ser Thr Leu Ala Phe Ala Leu Ala Asp Thr Val Phe Ser 
            180                 185                 190         


Thr Gln Asp Phe Leu Thr Leu Phe Tyr Thr Leu Arg Ser Tyr Ala Arg 
        195                 200                 205             


Gly Leu Arg Leu Glu Leu Thr Thr Tyr Leu Phe Gly Gln Asp Pro 
    210                 215                 220             


<210>  3
<211>  7895
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (116)..(3049)

<400>  3
gctgcctagt cagttctgcg tccgctgagg ctcggtcacc gcctcgctgt cgtcgcggcg       60

cccccgcccc gtcctctgtc cgtaccgccc ccggagccag ggccgagtcc tcgcc atg       118
                                                             Met          
                                                             1            

ccg gcc cgg cgg ctg ctg ctg ctg ctg acg ctg ctg ctg ccc ggc ctc        166
Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly Leu           
            5                   10                  15                    

ggg att ttt gga agt acc agc aca gtg acg ctt cct gaa acc ttg ttg        214
Gly Ile Phe Gly Ser Thr Ser Thr Val Thr Leu Pro Glu Thr Leu Leu           
        20                  25                  30                        

ttt gtg tca acg ctg gat gga agt ttg cat gct gtc agc aag agg aca        262
Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser Lys Arg Thr           
    35                  40                  45                            

ggc tca atc aaa tgg act tta aaa gaa gat cca gtc ctg cag gtc cca        310
Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu Gln Val Pro           
50                  55                  60                  65            

aca cat gtg gaa gag cct gcc ttt ctc cca gat cct aat gat ggc agc        358
Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn Asp Gly Ser           
                70                  75                  80                

ctg tat acg ctt gga agc aag aat aat gaa ggc ctg acg aaa ctt cct        406
Leu Tyr Thr Leu Gly Ser Lys Asn Asn Glu Gly Leu Thr Lys Leu Pro           
            85                  90                  95                    

ttt acc atc cca gaa ttg gtg cag gca tcc cca tgc cga agt tca gat        454
Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg Ser Ser Asp           
        100                 105                 110                       

gga atc ctc tac atg ggt aaa aag cag gac atc tgg tat gtt att gac        502
Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr Val Ile Asp           
    115                 120                 125                           

ctc ctg acc gga gag aag cag cag act ttg tca tcg gcc ttt gca gat        550
Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala Phe Ala Asp           
130                 135                 140                 145           

agt ctc tgc cca tca acc tct ctt ctg tat ctt ggg cga aca gaa tac        598
Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg Thr Glu Tyr           
                150                 155                 160               

acc atc acc atg tac gac acc aaa acc cga gag ctc cgg tgg aat gcc        646
Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg Trp Asn Ala           
            165                 170                 175                   

acc tac ttt gac tat gcg gcc tca ctg cct gag gac gac gtg gac tac        694
Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Asp Val Asp Tyr           
        180                 185                 190                       

aag atg tcc cac ttt gtg tcc aat ggt gat ggg ctg gtg gtg act gtg        742
Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val Val Thr Val           
    195                 200                 205                           

gac agt gaa tct ggg gac gtc ctg tgg atc caa aac tac gcc tcc cct        790
Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr Ala Ser Pro           
210                 215                 220                 225           

gtg gtg gcc ttt tat gtc tgg cag cgg gag ggt ctg agg aag gtg atg        838
Val Val Ala Phe Tyr Val Trp Gln Arg Glu Gly Leu Arg Lys Val Met           
                230                 235                 240               

cac atc aat gtc gct gtg gag acc ctg cgc tat ctg acc ttc atg tct        886
His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr Phe Met Ser           
            245                 250                 255                   

ggg gag gtg ggg cgc atc aca aag tgg aag tac ccg ttc ccc aag gag        934
Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe Pro Lys Glu           
        260                 265                 270                       

aca gag gcc aag agc aag ctg acg ccc act ctg tat gtt ggg aaa tac        982
Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val Gly Lys Tyr           
    275                 280                 285                           

tct acc agc ctc tat gcc tct ccc tca atg gta cac gag ggg gtt gct       1030
Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu Gly Val Ala           
290                 295                 300                 305           

gtc gtg ccc cgc ggc agc aca ctt cct ttg ctg gaa ggg ccc cag act       1078
Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly Pro Gln Thr           
                310                 315                 320               

gat ggc gtc acc att ggg gac aag ggg gag tgt gtg atc acg ccc agc       1126
Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile Thr Pro Ser           
            325                 330                 335                   

acg gac gtc aag ttt gat ccc gga ctc aaa agc aag aac aag ctc aac       1174
Thr Asp Val Lys Phe Asp Pro Gly Leu Lys Ser Lys Asn Lys Leu Asn           
        340                 345                 350                       

tac ttg agg aat tac tgg ctt ctg ata gga cac cat gaa acc cca ctg       1222
Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu Thr Pro Leu           
    355                 360                 365                           

tct gcg tct acc aag atg ctg gag aga ttt ccc aac aat cta ccc aaa       1270
Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn Leu Pro Lys           
370                 375                 380                 385           

cat cgg gaa aat gtg att cct gct gat tca gag aaa aag agc ttt gag       1318
His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Lys Ser Phe Glu           
                390                 395                 400               

gaa gtt atc aac ctg gtt gac cag act tca gaa aac gca cct acc acc       1366
Glu Val Ile Asn Leu Val Asp Gln Thr Ser Glu Asn Ala Pro Thr Thr           
            405                 410                 415                   

gtg tct cgg gat gtg gag gag aag ccc gcc cat gcc cct gcc cgg ccc       1414
Val Ser Arg Asp Val Glu Glu Lys Pro Ala His Ala Pro Ala Arg Pro           
        420                 425                 430                       

gag gcc ccc gtg gac tcc atg ctt aag gac atg gct acc atc atc ctg       1462
Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr Ile Ile Leu           
    435                 440                 445                           

agc acc ttc ctg ctg att ggc tgg gtg gcc ttc atc atc acc tat ccc       1510
Ser Thr Phe Leu Leu Ile Gly Trp Val Ala Phe Ile Ile Thr Tyr Pro           
450                 455                 460                 465           

ctg agc atg cat cag cag cag cag ctc cag cac cag cag ttc cag aag       1558
Leu Ser Met His Gln Gln Gln Gln Leu Gln His Gln Gln Phe Gln Lys           
                470                 475                 480               

gaa ctg gag aag atc cag ctc ctg cag cag cag cag cag cag ctg ccc       1606
Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Gln Gln Leu Pro           
            485                 490                 495                   

ttc cac cca cct gga gac acg gct cag gac ggc gag ctc ctg gac acg       1654
Phe His Pro Pro Gly Asp Thr Ala Gln Asp Gly Glu Leu Leu Asp Thr           
        500                 505                 510                       

tct ggc ccg tac tca gag agc tcg ggc acc agc agc ccc agc acg tcc       1702
Ser Gly Pro Tyr Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Thr Ser           
    515                 520                 525                           

ccc agg gcc tcc aac cac tcg ctc tgc tcc ggc agc tct gcc tcc aag       1750
Pro Arg Ala Ser Asn His Ser Leu Cys Ser Gly Ser Ser Ala Ser Lys           
530                 535                 540                 545           

gct ggc agc agc ccc tcc ctg gaa caa gac gat gga gat gag gaa acc       1798
Ala Gly Ser Ser Pro Ser Leu Glu Gln Asp Asp Gly Asp Glu Glu Thr           
                550                 555                 560               

agc gtg gtg ata gtt ggg aaa att tcc ttc tgt ccc aag gat gtc ctg       1846
Ser Val Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val Leu           
            565                 570                 575                   

ggc cat gga gct gag ggc aca att gtg tac cgg ggc atg ttt gac aac       1894
Gly His Gly Ala Glu Gly Thr Ile Val Tyr Arg Gly Met Phe Asp Asn           
        580                 585                 590                       

cgc gac gtg gcc gtg aag agg atc ctc ccc gag tgt ttt agc ttc gca       1942
Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe Ala           
    595                 600                 605                           

gac cgt gag gtc cag ctg ttg cga gaa tcg gat gag cac ccg aac gtg       1990
Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn Val           
610                 615                 620                 625           

atc cgc tac ttc tgc acg gag aag gac cgg caa ttc cag tac att gcc       2038
Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile Ala           
                630                 635                 640               

atc gag ctg tgt gca gcc acc ctg caa gag tat gtg gag cag aag gac       2086
Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys Asp           
            645                 650                 655                   

ttt gcg cat ctc ggc ctg gag ccc atc acc ttg ctg cag cag acc acc       2134
Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu Gln Gln Thr Thr           
        660                 665                 670                       

tcg ggc ctg gcc cac ctc cac tcc ctc aac atc gtt cac aga gac cta       2182
Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp Leu           
    675                 680                 685                           

aag cca cac aac atc ctc ata tcc atg ccc aat gca cac ggc aag atc       2230
Lys Pro His Asn Ile Leu Ile Ser Met Pro Asn Ala His Gly Lys Ile           
690                 695                 700                 705           

aag gcc atg atc tcc gac ttt ggc ctc tgc aag aag ctg gca gtg ggc       2278
Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val Gly           
                710                 715                 720               

aga cac agt ttc agc cgc cga tct ggg gtg cct ggc aca gaa ggc tgg       2326
Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly Trp           
            725                 730                 735                   

atc gct cca gag atg ctg agc gaa gac tgt aag gag aac cct acc tac       2374
Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Glu Asn Pro Thr Tyr           
        740                 745                 750                       

acg gtg gac atc ttt tct gca ggc tgc gtc ttt tac tac gta atc tct       2422
Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Ile Ser           
    755                 760                 765                           

gag ggc agc cac cct ttt ggc aag tcc ctg cag cgg cag gcc aac atc       2470
Glu Gly Ser His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn Ile           
770                 775                 780                 785           

ctc ctg ggt gcc tgc agc ctt gac tgc ttg cac cca gag aag cac gaa       2518
Leu Leu Gly Ala Cys Ser Leu Asp Cys Leu His Pro Glu Lys His Glu           
                790                 795                 800               

gac gtc att gca cgt gaa ttg ata gag aag atg att gcg atg gat cct       2566
Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp Pro           
            805                 810                 815                   

cag aaa cgc ccc tca gcg aag cat gtg ctc aaa cac ccg ttc ttc tgg       2614
Gln Lys Arg Pro Ser Ala Lys His Val Leu Lys His Pro Phe Phe Trp           
        820                 825                 830                       

agc cta gag aag cag ctc cag ttc ttc cag gac gtg agc gac aga ata       2662
Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg Ile           
    835                 840                 845                           

gaa aag gaa tcc ctg gat ggc ccg atc gtg aag cag tta gag aga ggc       2710
Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Lys Gln Leu Glu Arg Gly           
850                 855                 860                 865           

ggg aga gcc gtg gtg aag atg gac tgg cgg gag aac atc act gtc ccc       2758
Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Val Pro           
                870                 875                 880               

ctc cag aca gac ctg cgt aaa ttc agg acc tat aaa ggt ggt tct gtc       2806
Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser Val           
            885                 890                 895                   

aga gat ctc ctc cga gcc atg aga aat aag aag cac cac tac cgg gag       2854
Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg Glu           
        900                 905                 910                       

ctg cct gca gag gtg cgg gag acg ctg ggg tcc ctc ccc gac gac ttc       2902
Leu Pro Ala Glu Val Arg Glu Thr Leu Gly Ser Leu Pro Asp Asp Phe           
    915                 920                 925                           

gtg tgc tac ttc aca tct cgc ttc ccc cac ctc ctc gca cac acc tac       2950
Val Cys Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ala His Thr Tyr           
930                 935                 940                 945           

cgg gcc atg gag ctg tgc agc cac gag aga ctc ttc cag ccc tac tac       2998
Arg Ala Met Glu Leu Cys Ser His Glu Arg Leu Phe Gln Pro Tyr Tyr           
                950                 955                 960               

ttc cac gag ccc cca gag ccc cag ccc cca gtg act cca gac gcc ctc       3046
Phe His Glu Pro Pro Glu Pro Gln Pro Pro Val Thr Pro Asp Ala Leu           
            965                 970                 975                   

tga gcgagggcgg cccctctgtt ctggtggccc cagctgtgac tgagggcctg            3099

gtcaccacaa ttagagcttg atgcctcccg gctttgcagg gagaccaggc ttcccaaacc     3159

aagtgccttg agctgcctgc tctgcagccc acagaggaca gtgctgaccc caggaagtgg     3219

gagaagtggc ccctcgtgac ctacagggaa ctgggaagat gctggcccca aaagccttac     3279

ggtcatgatg tctgcaaagg agggcctcag agacagcgcg agtagcaccc ccagccatct     3339

actggataaa cttgcttcag actttttaaa ttcctgctta atgtcagtct acaggccttt     3399

caggaaggga gaggagggaa tcgtacattt tgcttgcgtg ctgggacagc taggctgaga     3459

tgcaccaagt acagccttca ctggagaccg gaattgagag gtgggggatg ctgaggaggg     3519

ggaggacgga gttcagaggg tgtcgtcctg cagtgtgaga tttctcattg atcacagatg     3579

tgcccagagt agcccaggtc actgttaact agtgtttctg cagaggcagc aggagccatg     3639

agcatgaggt gtggcattag ggactggtca gctatgcatg ctggcaggtg gggttgtgtc     3699

tgcaggtctc agaaatgaag aggctgctct gttctggagg cagccgtggc ccagtgccag     3759

tggccagaac agtggccttt ggtgggtgtg tcccgggcca tctcggggtg gtgctcagga     3819

gcgcctgggg caagaggtaa agagttccct ggccttcaag gagagcagcg aagacccaga     3879

caggggccag ccttcaggac cagagggagg ccgccgaatg ggaccctcct ggtcaccagg     3939

agaaagccct gggccagcga gtaggcagtc aaactccttc gtccccaagg ccggtggaac     3999

aagaggctcg tggtgagtca gggccagggt gggtggccaa ggccagggtc accgtgtgct     4059

tcatgggcca gcttttttgt ttttcttggc aaattttaat aactatattt tgattatact     4119

gtagaatgct atgtcagcat aagtaagcta aacttgaagc tttcttgtga agaataaatg     4179

caagatagaa tacatcttct attttttgtg gtaccaaaaa tcaccatccc ctcaagagtg     4239

ttcatgtata gaacattctc taatgctgaa gagtaaaaca ttatagcaac actatgtaaa     4299

tgtattgaac agtatcaaag aaatagtctc taaattgttt gtaccatatt tttttttcta     4359

aacttaacat aatttttagc tttagtttca gtcaaaactt tgtcttttct ctcccgagag     4419

ccttagaggt taaaatgcaa tcagcctacc gtgtaaggag atgttgtcca tgtactttct     4479

ccagccagtt gggggatcat tgcagctcag gcctggtgaa ctcagagatt ccattcagta     4539

ttaagaatgg gattgttgaa ttttactcac agagaaatca ctgtttcttc atgttgtaag     4599

atgttttctg tttgtgtatt tgtatcatgg ttactcatca aaagctctca ttctgccttt     4659

gtagaattca gttcccttcc tttcatcata gctaaagtga cttttttccc tactattaac     4719

gtgatcctac atccttaaat ctcatcgatt acctcactta ggccttggaa ccttggccct     4779

tggtcggtgt ccttggcgtc ttctaagcaa ggctgtgcgt tgttcagaaa cgtggccaga     4839

ccgcatttcc tgctgctccc atgccgcatg ccaggtggcc tgagacagag ctccccatac     4899

ggctgcaagg tgctttacct gtgggctttg gcagtaaccc aagagaggat cagaaggtgg     4959

agaaggtgcc acgagtgatt taacaggcct gccacaggga gtgcccccag cccagctcgt     5019

tctcagcaca ggttttctct ttgggagtac ccaggtgatt tctagtgacc caattttgtg     5079

tcatctccct gttttagccc cacttgccta gagacaactg tttccgatgc cttttctgct     5139

tatcatacta gtttctaacc acgcagattt ctcaaaatca tttattcaat gtattttatt     5199

tgagcactta gtgtattgag ctaggcagga tatagggtgc cggagataca gcgatgaaca     5259

agacaggcaa aacttctgct ttcctaaaac ttgtgatgag agagaacaat aaaaaagtgt     5319

tgctgccaca aagaaaccaa agtgtgtggg gaagggcgcg tgtttgcggt ttacatctct     5379

tctgtcccag aatcacaggg atctggtccg gtcacctctg gtctttcctc ttagtcgcct     5439

ttaggagccc tggttcccgt ccatcctctg gggggtttgt ttgaagagat ctcgtgtggg     5499

tacttgtcat gaaaacacct tgggcatcat ctggtgtatc cagttctagt ctcgagaatt     5559

ctggtttccc actgtgctca gcaagtggaa agttcttttc aggccagaac agctctgcac     5619

catcacatat cgtgttgcgg cttagctgtt tggtctgtag ttcaggttat gggacttctc     5679

caatcctgga aggctgttga gctttttaga agtactgtac gctatcttca agatggagct     5739

tggtcacatc tgttaggaat ccaaaggaca ctatgactta tttaaatctt gtcttactaa     5799

acctctcttg ggcacgtgtg ccagaatttc tcttgttgct tcttgagtct ttttaatttc     5859

agtgtttttt cgtttgtttt ttgttttttt gagacagagt ctcgctctgt cacccaggct     5919

ggagtgcagt ggcacgacct cagctcactg caacctccgc ctccttggtt caagcaattc     5979

tcctgcctca gcctcccgag tagctgggat tacaggtgtg tgccaccacg ctcggctaat     6039

tttttatatt ttttttagta gagacggggt ttccccatgt taggcaggat ggtctcgatc     6099

tcctaacctc gtgatccgcc tgcctcagcc tcccaaagtg ctgggattac aggcttgagc     6159

caccgcaccc ggcctaatct cagtttttga agtgctccac aagtcattag gcaccaaaac     6219

attttcacct ggggaacact ggcatttccc tgattagctg tgaagcaatc tagtggctaa     6279

gtgtgaaatc ctgggtgcgc aggtgttctc actcccgccg tgttctcagt gcagtggtgg     6339

tcagaggccc ttccaaggag acatcactct gatcagttac agatagatgt tctggaagat     6399

ctgcaggtga gtagatccag cagagtttct tcccaccaac tctagaagaa agggccttat     6459

cagagttgac cctgagcctt tggtaaggtt ttgtgtgcat gcgattcagt tatctttggc     6519

aattcttttc ttgctgcagt gagagattaa ttggttgctg atcaaaccgt tcatgcagat     6579

ggggggacct ttggattgta cggctttctc ctcttggctg ctttcttttc aggaagttgg     6639

actttggcca ggtttggctt tcccagagcc gttcctttct ctgtcctttc cttgggtcct     6699

catggtgtgc ccattggatc cttggccttg tgatcctctg ggaactgggg gccagttcca     6759

cttttgcagc cttctgtgct ggaagagaag cccagcgccc tggaaggagc ctctttaagt     6819

cccccatgtc gctttctctc tctgctcttt tagtgtctga gattgccttt ctttgaattt     6879

cccagtgttt cttttccttg tcccttccct caccaacctg gagttatttt ggttgactat     6939

gtcctggctt tggcttctcc tggcaggaag tcatcaggca tcctctccag gtgagccgaa     6999

attccaccct cccaggttgg acatcatctt ttaaacccaa tggtctactc ccctccttct     7059

ttatgaaaca gtgatttccc gtgagtaact ctggttctga ttttttgtac cggcgcttaa     7119

attctttctg tagacgttgg aaagccacaa agaacgtgac tgcagtgagc ctcccactgg     7179

agcagcctta accaacactt tggccaaagc ccccccacct cccctgtgta ctgtgtgtgt     7239

gtttggtgga tacagtattc cttttcagtg tccctaaagc tgtgatgggg agtccccact     7299

tacctagaaa gcattaccag tcacctactc tgcattctca gatgtaaacc ttgtgtagtg     7359

ttctttttgc aatgacctat ttatttaacc tatttatatt tatttaattt ttactctgaa     7419

atgtatccag ttacaattgt acttgcttaa agcacatcag atttgttttg gacaacaccc     7479

ttgaccattt taaaactgga aaagtgatac tgtatccttc catgggatgg atgctttaca     7539

gtagtcttat tattaaaggg tgattaattt ggtcggggta aaatgttaat ttttaggtga     7599

tttttaagaa ttctgtgcca ttatgtcttc tgtgtggatg gttaattgtt taattagtac     7659

gtgttaattg tgtgatacag tcttctttgt ggaacccaaa atcctctttt tagctttata     7719

ttttataaac tgccagattg tacaactttt atgtgcattt ttaaagcttg aagacatgag     7779

ggtcattatc taagttaaac agcctatttt tgtgcctcct gtacagtttt ataattctgc     7839

tgatggcggc atcttatgtc gagccaacca caataaaggt agttttagat tttgga         7895


<210>  4
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Ala Arg Arg Leu Leu Leu Leu Leu Thr Leu Leu Leu Pro Gly 
1               5                   10                  15      


Leu Gly Ile Phe Gly Ser Thr Ser Thr Val Thr Leu Pro Glu Thr Leu 
            20                  25                  30          


Leu Phe Val Ser Thr Leu Asp Gly Ser Leu His Ala Val Ser Lys Arg 
        35                  40                  45              


Thr Gly Ser Ile Lys Trp Thr Leu Lys Glu Asp Pro Val Leu Gln Val 
    50                  55                  60                  


Pro Thr His Val Glu Glu Pro Ala Phe Leu Pro Asp Pro Asn Asp Gly 
65                  70                  75                  80  


Ser Leu Tyr Thr Leu Gly Ser Lys Asn Asn Glu Gly Leu Thr Lys Leu 
                85                  90                  95      


Pro Phe Thr Ile Pro Glu Leu Val Gln Ala Ser Pro Cys Arg Ser Ser 
            100                 105                 110         


Asp Gly Ile Leu Tyr Met Gly Lys Lys Gln Asp Ile Trp Tyr Val Ile 
        115                 120                 125             


Asp Leu Leu Thr Gly Glu Lys Gln Gln Thr Leu Ser Ser Ala Phe Ala 
    130                 135                 140                 


Asp Ser Leu Cys Pro Ser Thr Ser Leu Leu Tyr Leu Gly Arg Thr Glu 
145                 150                 155                 160 


Tyr Thr Ile Thr Met Tyr Asp Thr Lys Thr Arg Glu Leu Arg Trp Asn 
                165                 170                 175     


Ala Thr Tyr Phe Asp Tyr Ala Ala Ser Leu Pro Glu Asp Asp Val Asp 
            180                 185                 190         


Tyr Lys Met Ser His Phe Val Ser Asn Gly Asp Gly Leu Val Val Thr 
        195                 200                 205             


Val Asp Ser Glu Ser Gly Asp Val Leu Trp Ile Gln Asn Tyr Ala Ser 
    210                 215                 220                 


Pro Val Val Ala Phe Tyr Val Trp Gln Arg Glu Gly Leu Arg Lys Val 
225                 230                 235                 240 


Met His Ile Asn Val Ala Val Glu Thr Leu Arg Tyr Leu Thr Phe Met 
                245                 250                 255     


Ser Gly Glu Val Gly Arg Ile Thr Lys Trp Lys Tyr Pro Phe Pro Lys 
            260                 265                 270         


Glu Thr Glu Ala Lys Ser Lys Leu Thr Pro Thr Leu Tyr Val Gly Lys 
        275                 280                 285             


Tyr Ser Thr Ser Leu Tyr Ala Ser Pro Ser Met Val His Glu Gly Val 
    290                 295                 300                 


Ala Val Val Pro Arg Gly Ser Thr Leu Pro Leu Leu Glu Gly Pro Gln 
305                 310                 315                 320 


Thr Asp Gly Val Thr Ile Gly Asp Lys Gly Glu Cys Val Ile Thr Pro 
                325                 330                 335     


Ser Thr Asp Val Lys Phe Asp Pro Gly Leu Lys Ser Lys Asn Lys Leu 
            340                 345                 350         


Asn Tyr Leu Arg Asn Tyr Trp Leu Leu Ile Gly His His Glu Thr Pro 
        355                 360                 365             


Leu Ser Ala Ser Thr Lys Met Leu Glu Arg Phe Pro Asn Asn Leu Pro 
    370                 375                 380                 


Lys His Arg Glu Asn Val Ile Pro Ala Asp Ser Glu Lys Lys Ser Phe 
385                 390                 395                 400 


Glu Glu Val Ile Asn Leu Val Asp Gln Thr Ser Glu Asn Ala Pro Thr 
                405                 410                 415     


Thr Val Ser Arg Asp Val Glu Glu Lys Pro Ala His Ala Pro Ala Arg 
            420                 425                 430         


Pro Glu Ala Pro Val Asp Ser Met Leu Lys Asp Met Ala Thr Ile Ile 
        435                 440                 445             


Leu Ser Thr Phe Leu Leu Ile Gly Trp Val Ala Phe Ile Ile Thr Tyr 
    450                 455                 460                 


Pro Leu Ser Met His Gln Gln Gln Gln Leu Gln His Gln Gln Phe Gln 
465                 470                 475                 480 


Lys Glu Leu Glu Lys Ile Gln Leu Leu Gln Gln Gln Gln Gln Gln Leu 
                485                 490                 495     


Pro Phe His Pro Pro Gly Asp Thr Ala Gln Asp Gly Glu Leu Leu Asp 
            500                 505                 510         


Thr Ser Gly Pro Tyr Ser Glu Ser Ser Gly Thr Ser Ser Pro Ser Thr 
        515                 520                 525             


Ser Pro Arg Ala Ser Asn His Ser Leu Cys Ser Gly Ser Ser Ala Ser 
    530                 535                 540                 


Lys Ala Gly Ser Ser Pro Ser Leu Glu Gln Asp Asp Gly Asp Glu Glu 
545                 550                 555                 560 


Thr Ser Val Val Ile Val Gly Lys Ile Ser Phe Cys Pro Lys Asp Val 
                565                 570                 575     


Leu Gly His Gly Ala Glu Gly Thr Ile Val Tyr Arg Gly Met Phe Asp 
            580                 585                 590         


Asn Arg Asp Val Ala Val Lys Arg Ile Leu Pro Glu Cys Phe Ser Phe 
        595                 600                 605             


Ala Asp Arg Glu Val Gln Leu Leu Arg Glu Ser Asp Glu His Pro Asn 
    610                 615                 620                 


Val Ile Arg Tyr Phe Cys Thr Glu Lys Asp Arg Gln Phe Gln Tyr Ile 
625                 630                 635                 640 


Ala Ile Glu Leu Cys Ala Ala Thr Leu Gln Glu Tyr Val Glu Gln Lys 
                645                 650                 655     


Asp Phe Ala His Leu Gly Leu Glu Pro Ile Thr Leu Leu Gln Gln Thr 
            660                 665                 670         


Thr Ser Gly Leu Ala His Leu His Ser Leu Asn Ile Val His Arg Asp 
        675                 680                 685             


Leu Lys Pro His Asn Ile Leu Ile Ser Met Pro Asn Ala His Gly Lys 
    690                 695                 700                 


Ile Lys Ala Met Ile Ser Asp Phe Gly Leu Cys Lys Lys Leu Ala Val 
705                 710                 715                 720 


Gly Arg His Ser Phe Ser Arg Arg Ser Gly Val Pro Gly Thr Glu Gly 
                725                 730                 735     


Trp Ile Ala Pro Glu Met Leu Ser Glu Asp Cys Lys Glu Asn Pro Thr 
            740                 745                 750         


Tyr Thr Val Asp Ile Phe Ser Ala Gly Cys Val Phe Tyr Tyr Val Ile 
        755                 760                 765             


Ser Glu Gly Ser His Pro Phe Gly Lys Ser Leu Gln Arg Gln Ala Asn 
    770                 775                 780                 


Ile Leu Leu Gly Ala Cys Ser Leu Asp Cys Leu His Pro Glu Lys His 
785                 790                 795                 800 


Glu Asp Val Ile Ala Arg Glu Leu Ile Glu Lys Met Ile Ala Met Asp 
                805                 810                 815     


Pro Gln Lys Arg Pro Ser Ala Lys His Val Leu Lys His Pro Phe Phe 
            820                 825                 830         


Trp Ser Leu Glu Lys Gln Leu Gln Phe Phe Gln Asp Val Ser Asp Arg 
        835                 840                 845             


Ile Glu Lys Glu Ser Leu Asp Gly Pro Ile Val Lys Gln Leu Glu Arg 
    850                 855                 860                 


Gly Gly Arg Ala Val Val Lys Met Asp Trp Arg Glu Asn Ile Thr Val 
865                 870                 875                 880 


Pro Leu Gln Thr Asp Leu Arg Lys Phe Arg Thr Tyr Lys Gly Gly Ser 
                885                 890                 895     


Val Arg Asp Leu Leu Arg Ala Met Arg Asn Lys Lys His His Tyr Arg 
            900                 905                 910         


Glu Leu Pro Ala Glu Val Arg Glu Thr Leu Gly Ser Leu Pro Asp Asp 
        915                 920                 925             


Phe Val Cys Tyr Phe Thr Ser Arg Phe Pro His Leu Leu Ala His Thr 
    930                 935                 940                 


Tyr Arg Ala Met Glu Leu Cys Ser His Glu Arg Leu Phe Gln Pro Tyr 
945                 950                 955                 960 


Tyr Phe His Glu Pro Pro Glu Pro Gln Pro Pro Val Thr Pro Asp Ala 
                965                 970                 975     


Leu 
    


<210>  5
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  5
uugcauaguc acaaaaguga uc                                                22


<210>  6
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  6
cguguucaca gcggaccuug au                                                22


<210>  7
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  7
ugagugugug ugugugagug ugu                                               23


<210>  8
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  8
cacacacaca cacacacgua u                                                 21


<210>  9
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  9
cugggcccgc ggcgggcgug ggg                                               23


<210>  10
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  10
gcacgugaau ugauagaga                                                    19


<210>  11
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  11
ucucuaucaa uucacgugc                                                    19


