                         SEQUENCE LISTING

<110>  Genentech, Inc.
 
<120>  DIAGNOSTIC METHODS AND COMPOSITIONS FOR CANCER IMMUNOTHERAPY

<130>  50474-188WO3

<150>  62/938,427
<151>  2019-11-21

<150>  62/775,720
<151>  2018-12-05

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  458
<212>  DNA
<213>  Homo sapiens

<400>  1
ggtgtgccct tctctgtttc agactctgag ctgctactct gaagtctggg tcgtgccctg       60

gctccagcac ttcgaggtgc ctgttctccg ttgtcactga cccccgcctc ttcagcaaga      120

ccacagccat gacaaacacc aggatgcatg ctccttgtcc cctcccaccc gcctcatgac      180

ccagcctcac agaccctctc aggcctctga cgagtgagcg ggtgaagtgc cactgggtca      240

ccgcagggca gctggaatgg cagcatggta gcacctccta acagattaaa tagatcacat      300

ttgcttctaa aattaactcc tgtttctgag gcttcccacc tagattccgg gtctgggtgc      360

aggggactga gtcaatggag ggagttgtga aactaaggga tgatcccctg tggctacagg      420

cccccaggag agcaggggta cagctctggg tctgaata                              458


<210>  2
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Ala Ala Gly Thr Leu Leu Ala Phe Cys Cys Leu Val Leu Ser 
1               5                   10                  15      


Thr Thr Gly Gly Pro Ser Pro Asp Thr Cys Ser Gln Asp Leu Asn Ser 
            20                  25                  30          


Arg Val Lys Pro Gly Phe Pro Lys Thr Ile Lys Thr Asn Asp Pro Gly 
        35                  40                  45              


Val Leu Gln Ala Ala Arg Tyr Ser Val Glu Lys Phe Asn Asn Cys Thr 
    50                  55                  60                  


Asn Asp Met Phe Leu Phe Lys Glu Ser Arg Ile Thr Arg Ala Leu Val 
65                  70                  75                  80  


Gln Ile Val Lys Gly Leu Lys Tyr Met Leu Glu Val Glu Ile Gly Arg 
                85                  90                  95      


Thr Thr Cys Lys Lys Asn Gln His Leu Arg Leu Asp Asp Cys Asp Phe 
            100                 105                 110         


Gln Thr Asn His Thr Leu Lys Gln Thr Leu Ser Cys Tyr Ser Glu Val 
        115                 120                 125             


Trp Val Val Pro Trp Leu Gln His Phe Glu Val Pro Val Leu Arg Cys 
    130                 135                 140                 


His 
145 


<210>  3
<211>  783
<212>  DNA
<213>  Homo sapiens

<400>  3
cccaggagtc tgggtgcaca gcctccttct ctctgagatt caagagtctg atcagcagcc       60

tcttcctcct ccaggaccca gaagccctga gcttatcccc atggagctct gccggtccct      120

ggccctgctg gggggctccc tgggcctgat gttctgcctg attgctttga gcaccgattt      180

ctggtttgag gctgtgggtc ccacccactc agctcactcg ggcctctggc caacagggca      240

tggggacatc atatcaggct acatccacgt gacgcagacc ttcagcatta tggctgttct      300

gtgggccctg gtgtccgtga gcttcctggt cctgtcctgc ttcccctcac tgttcccccc      360

aggccacggc ccgcttgtct caaccaccgc agcctttgct gcagccatct ccatggtggt      420

ggccatggcg gtgtacacca gcgagcggtg ggaccagcct ccacaccccc agatccagac      480

cttcttctcc tggtccttct acctgggctg ggtctcagct atcctcttgc tctgtacagg      540

tgccctgagc ctgggtgctc actgtggcgg tccccgtcct ggctatgaaa ccttgtgagc      600

agaaggcaag agcggcaaga tgagttttga gcgttgtatt ccaaaggcct catctggagc      660

ctcgggaaag tctggtccta catttgcccg cccttccagc ccttccccag cccctcctct      720

tgtttcttca ttcattcaac aaaatttggc tggaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaa                                                                    783


<210>  4
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Leu Cys Arg Ser Leu Ala Leu Leu Gly Gly Ser Leu Gly Leu 
1               5                   10                  15      


Met Phe Cys Leu Ile Ala Leu Ser Thr Asp Phe Trp Phe Glu Ala Val 
            20                  25                  30          


Gly Pro Thr His Ser Ala His Ser Gly Leu Trp Pro Thr Gly His Gly 
        35                  40                  45              


Asp Ile Ile Ser Gly Tyr Ile His Val Thr Gln Thr Phe Ser Ile Met 
    50                  55                  60                  


Ala Val Leu Trp Ala Leu Val Ser Val Ser Phe Leu Val Leu Ser Cys 
65                  70                  75                  80  


Phe Pro Ser Leu Phe Pro Pro Gly His Gly Pro Leu Val Ser Thr Thr 
                85                  90                  95      


Ala Ala Phe Ala Ala Ala Ile Ser Met Val Val Ala Met Ala Val Tyr 
            100                 105                 110         


Thr Ser Glu Arg Trp Asp Gln Pro Pro His Pro Gln Ile Gln Thr Phe 
        115                 120                 125             


Phe Ser Trp Ser Phe Tyr Leu Gly Trp Val Ser Ala Ile Leu Leu Leu 
    130                 135                 140                 


Cys Thr Gly Ala Leu Ser Leu Gly Ala His Cys Gly Gly Pro Arg Pro 
145                 150                 155                 160 


Gly Tyr Glu Thr Leu 
                165 


<210>  5
<211>  741
<212>  DNA
<213>  Homo sapiens

<400>  5
atgcagccat tcctcctcct gttggccttt cttctgaccc ctggggctgg gacagaggag       60

atcatcgggg gccatgaggc caagccccac tcccgcccct acatggcctt tgttcagttt      120

ctgcaagaga agagtcggaa gaggtgtggc ggcatcctag tgagaaagga ctttgtgctg      180

acagctgctc actgccaggg aagctccata aatgtcacct tgggggccca caatatcaag      240

gaacaggagc ggacccagca gtttatccct gtgaaaagac ccatccccca tccagcctat      300

aatcctaaga acttctccaa cgacatcatg ctactgcagc tggagagaaa ggccaagtgg      360

accacagctg tgcggcctct caggctacct agcagcaagg cccaggtgaa gccagggcag      420

ctgtgcagtg tggctggctg gggttatgtc tcaatgagca ctttagcaac cacactgcag      480

gaagtgttgc tgacagtgca gaaggactgc cagtgtgaac gtctcttcca tggcaattac      540

agcagagcca ctgagatttg tgtgggggat ccaaagaaga cacagaccgg tttcaagggg      600

gactccgggg ggcccctcgt gtgtaaggac gtagcccaag gtattctctc ctatggaaac      660

aaaaaaggga cacctccagg agtctacatc aaggtctcac acttcctgcc ctggataaag      720

agaacaatga agcgcctcta a                                                741


<210>  6
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gln Pro Phe Leu Leu Leu Leu Ala Phe Leu Leu Thr Pro Gly Ala 
1               5                   10                  15      


Gly Thr Glu Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Phe Val Gln Phe Leu Gln Glu Lys Ser Arg Lys Arg 
        35                  40                  45              


Cys Gly Gly Ile Leu Val Arg Lys Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Gln Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys 
65                  70                  75                  80  


Glu Gln Glu Arg Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro 
                85                  90                  95      


His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Glu Arg Lys Ala Lys Trp Thr Thr Ala Val Arg Pro Leu Arg 
        115                 120                 125             


Leu Pro Ser Ser Lys Ala Gln Val Lys Pro Gly Gln Leu Cys Ser Val 
    130                 135                 140                 


Ala Gly Trp Gly Tyr Val Ser Met Ser Thr Leu Ala Thr Thr Leu Gln 
145                 150                 155                 160 


Glu Val Leu Leu Thr Val Gln Lys Asp Cys Gln Cys Glu Arg Leu Phe 
                165                 170                 175     


His Gly Asn Tyr Ser Arg Ala Thr Glu Ile Cys Val Gly Asp Pro Lys 
            180                 185                 190         


Lys Thr Gln Thr Gly Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
        195                 200                 205             


Lys Asp Val Ala Gln Gly Ile Leu Ser Tyr Gly Asn Lys Lys Gly Thr 
    210                 215                 220                 


Pro Pro Gly Val Tyr Ile Lys Val Ser His Phe Leu Pro Trp Ile Lys 
225                 230                 235                 240 


Arg Thr Met Lys Arg Leu 
                245     


<210>  7
<211>  1378
<212>  DNA
<213>  Homo sapiens

<400>  7
atgctaaaac taatcgtccc aacaattata ttactaccac tgacatgact ttccaaaaaa       60

cacataattt gaatcaacac aaccacccac agcctaatta ttagcatcat ccctctacta      120

ttttttaacc aaatcaacaa caacctattt agctgttccc caaccttttc ctccgacccc      180

ctaacaaccc ccctcctaat actaactacc tgactcctac ccctcacaat catggcaagc      240

caacgccact tatccagtga accactatca cgaaaaaaac tctacctctc tatactaatc      300

tccctacaaa tctccttaat tataacattc acagccacag aactaatcat attttatatc      360

ttcttcgaaa ccacacttat ccccaccttg gctatcatca cccgatgagg caaccagcca      420

gaacgcctga acgcaggcac atacttccta ttctacaccc tagtaggctc ccttccccta      480

ctcatcgcac taatttacac tcacaacacc ctaggctcac taaacattct actactcact      540

ctcactgccc aagaactatc aaactcctga gccaacaact taatatgact agcttacaca      600

atagctttta tagtaaagat acctctttac ggactccact tatgactccc taaagcccat      660

gtcgaagccc ccatcgctgg gtcaatagta cttgccgcag tactcttaaa actaggcggc      720

tatggtataa tacgcctcac actcattctc aaccccctga caaaacacat agcctacccc      780

ttccttgtac tatccctatg aggcataatt ataacaagct ccatctgcct acgacaaaca      840

gacctaaaat cgctcattgc atactcttca atcagccaca tagccctcgt agtaacagcc      900

attctcatcc aaaccccctg aagcttcacc ggcgcagtca ttctcataat cgcccacggg      960

cttacatcct cattactatt ctgcctagca aactcaaact acgaacgcac tcacagtcgc     1020

atcataatcc tctctcaagg acttcaaact ctactcccac taatagcttt ttgatgactt     1080

ctagcaagcc tcgctaacct cgccttaccc cccactatta acctactggg agaactctct     1140

gtgctagtaa ccacgttctc ctgatcaaat atcactctcc tacttacagg actcaacata     1200

ctagtcacag ccctatactc cctctacata tttaccacaa cacaatgggg ctcactcacc     1260

caccacatta acaacataaa accctcattc acacgagaaa acaccctcat gttcatacac     1320

ctatccccca ttctcctcct atccctcaac cccgacatca ttaccgggtt ttcctctt       1378


<210>  8
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Lys Leu Ile Val Pro Thr Ile Met Leu Leu Pro Leu Thr Trp 
1               5                   10                  15      


Leu Ser Lys Lys His Met Ile Trp Ile Asn Thr Thr Thr His Ser Leu 
            20                  25                  30          


Ile Ile Ser Ile Ile Pro Leu Leu Phe Phe Asn Gln Ile Asn Asn Asn 
        35                  40                  45              


Leu Phe Ser Cys Ser Pro Thr Phe Ser Ser Asp Pro Leu Thr Thr Pro 
    50                  55                  60                  


Leu Leu Met Leu Thr Thr Trp Leu Leu Pro Leu Thr Ile Met Ala Ser 
65                  70                  75                  80  


Gln Arg His Leu Ser Ser Glu Pro Leu Ser Arg Lys Lys Leu Tyr Leu 
                85                  90                  95      


Ser Met Leu Ile Ser Leu Gln Ile Ser Leu Ile Met Thr Phe Thr Ala 
            100                 105                 110         


Thr Glu Leu Ile Met Phe Tyr Ile Phe Phe Glu Thr Thr Leu Ile Pro 
        115                 120                 125             


Thr Leu Ala Ile Ile Thr Arg Trp Gly Asn Gln Pro Glu Arg Leu Asn 
    130                 135                 140                 


Ala Gly Thr Tyr Phe Leu Phe Tyr Thr Leu Val Gly Ser Leu Pro Leu 
145                 150                 155                 160 


Leu Ile Ala Leu Ile Tyr Thr His Asn Thr Leu Gly Ser Leu Asn Ile 
                165                 170                 175     


Leu Leu Leu Thr Leu Thr Ala Gln Glu Leu Ser Asn Ser Trp Ala Asn 
            180                 185                 190         


Asn Leu Met Trp Leu Ala Tyr Thr Met Ala Phe Met Val Lys Met Pro 
        195                 200                 205             


Leu Tyr Gly Leu His Leu Trp Leu Pro Lys Ala His Val Glu Ala Pro 
    210                 215                 220                 


Ile Ala Gly Ser Met Val Leu Ala Ala Val Leu Leu Lys Leu Gly Gly 
225                 230                 235                 240 


Tyr Gly Met Met Arg Leu Thr Leu Ile Leu Asn Pro Leu Thr Lys His 
                245                 250                 255     


Met Ala Tyr Pro Phe Leu Val Leu Ser Leu Trp Gly Met Ile Met Thr 
            260                 265                 270         


Ser Ser Ile Cys Leu Arg Gln Thr Asp Leu Lys Ser Leu Ile Ala Tyr 
        275                 280                 285             


Ser Ser Ile Ser His Met Ala Leu Val Val Thr Ala Ile Leu Ile Gln 
    290                 295                 300                 


Thr Pro Trp Ser Phe Thr Gly Ala Val Ile Leu Met Ile Ala His Gly 
305                 310                 315                 320 


Leu Thr Ser Ser Leu Leu Phe Cys Leu Ala Asn Ser Asn Tyr Glu Arg 
                325                 330                 335     


Thr His Ser Arg Ile Met Ile Leu Ser Gln Gly Leu Gln Thr Leu Leu 
            340                 345                 350         


Pro Leu Met Ala Phe Trp Trp Leu Leu Ala Ser Leu Ala Asn Leu Ala 
        355                 360                 365             


Leu Pro Pro Thr Ile Asn Leu Leu Gly Glu Leu Ser Val Leu Val Thr 
    370                 375                 380                 


Thr Phe Ser Trp Ser Asn Ile Thr Leu Leu Leu Thr Gly Leu Asn Met 
385                 390                 395                 400 


Leu Val Thr Ala Leu Tyr Ser Leu Tyr Met Phe Thr Thr Thr Gln Trp 
                405                 410                 415     


Gly Ser Leu Thr His His Ile Asn Asn Met Lys Pro Ser Phe Thr Arg 
            420                 425                 430         


Glu Asn Thr Leu Met Phe Met His Leu Ser Pro Ile Leu Leu Leu Ser 
        435                 440                 445             


Leu Asn Pro Asp Ile Ile Thr Gly Phe Ser Ser 
    450                 455                 


<210>  9
<211>  1080
<212>  DNA
<213>  Homo sapiens

<400>  9
atggcgcccc gaaccctcct cctgctgctc tcaggggccc tggccctgac ccagacctgg       60

gcgcgttccc actccatgag gtatttctac accaccatgt cccggcccgg cgccggggag      120

ccccgcttca tctccgtcgg ctacgtggac gatacgcagt tcgtgcggtt cgacagcgac      180

gacgcgagtc cgagagagga gccgcgggcg ccgtggatgg agcgggaggg gccaaagtat      240

tgggaccgga acacacagat ctgcaaggcc caggcacaga ctgaacgaga gaacctgcgg      300

atcgcgctcc gctactacaa ccagagcgag ggcggttctc acaccatgca ggtgatgtat      360

ggctgcgacg tggggcccga cgggcctttc ctccgcgggt atgaacagca cgcctacgac      420

ggcaaggatt acatcgccct gaacgaggac ctgcgctcct ggaccgcggc ggacatggca      480

gctcagatca ccaagcgcaa gtgggaggcg gcccgtcggg cggagcagcg gagagtctac      540

ttggagggcg agttcgtgga gtggctccgc agatacttgg agaacgggaa ggagacgctg      600

cagcgcgcgg acccccccaa gacacatatg acccaccacc ccatctctga ccatgaggcc      660

accctgaggt gctgggccct gggcttctac cctgcggaga tcacactgac ctggcagcgg      720

gatggggagg accagaccca ggacacggag ctcgtggaga ccaggcctgc aggggatgga      780

accttccaga agtgggcggc tgtggtggtg ccttctggag aggagcagag atacacctgc      840

catgtgcagc atgagggtct gcccgagccc ctcaccctga gatgggagcc atcttcccag      900

cccaccgtcc ccatcgtggg catcgttgct ggcttggttc tacttgtagc tgtggtcact      960

ggagctgtgg tcgctgctgt aatgtggagg aagaagagct cagatagaaa aggagggagc     1020

tactctcagg ctgcaagcag caacagtgcc cagggctctg atgtgtctct cacggcttga     1080


<210>  10
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Leu Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Arg Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Thr Met Ser Arg Pro Gly Ala Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Asp 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Met Glu Arg Glu Gly 
65                  70                  75                  80  


Pro Lys Tyr Trp Asp Arg Asn Thr Gln Ile Cys Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Glu Arg Glu Asn Leu Arg Ile Ala Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Gly Gly Ser His Thr Met Gln Val Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Pro Phe Leu Arg Gly Tyr Glu Gln His Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala Arg Arg 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Glu Phe Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Val Leu Leu Val Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asn Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  11
<211>  309
<212>  DNA
<213>  Homo sapiens

<400>  11
accatgaagg tctccgcggc agccctcgct gtcatcctca ttgctactgc cctctgcgct       60

cctgcatctg cctccccata ttcctcggac accacaccct gctgctttgc ctacattgcc      120

cgcccactgc cccgtgccca catcaaggag tatttctaca ccagtggcaa gtgctccaac      180

ccagcagtcg tctttgtcac ccgaaagaac cgccaagtgt gtgccaaccc agagaagaaa      240

tgggttcggg agtacatcaa ctctttggag atgagctagg atggagagtc cttgaacctg      300

aacttacac                                                              309


<210>  12
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  13
<211>  1060
<212>  DNA
<213>  Homo sapiens

<400>  13
cggctcccgc gccgcctccc ctcgcgcccg agcttcgagc caagcagcgt cctggggagc       60

gcgtcatggc cttaccagtg accgccttgc tcctgccgct ggccttgctg ctccacgccg      120

ccaggccgag ccagttccgg gtgtcgccgc tggatcggac ctggaacctg ggcgagacag      180

tggagctgaa gtgccaggtg ctgctgtcca acccgacgtc gggctgctcg tggctcttcc      240

agccgcgcgg cgccgccgcc agtcccacct tcctcctata cctctcccaa aacaagccca      300

aggcggccga ggggctggac acccagcggt tctcgggcaa gaggttgggg gacaccttcg      360

tcctcaccct gagcgacttc cgccgagaga acgagggcta ctatttctgc tcggccctga      420

gcaactccat catgtacttc agccacttcg tgccggtctt cctgccagcg aagcccacca      480

cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag cccctgtccc      540

tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg gggctggact      600

tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc cttctcctgt      660

cactggttat caccctttac tgcaaccaca ggaaccgaag acgtgtttgc aaatgtcccc      720

ggcctgtggt caaatcggga gacaagccca gcctttcggc gagatacgtc taaccctgtg      780

caacagccac tacattactt caaactgaga tccttccttt tgagggagca agtccttccc      840

tttcattttt tccagtcttc ctccctgtgt attcattctc atgattatta ttttagtggg      900

ggcggggtgg gaaagattac tttttcttta tgtgtttgac gggaaacaaa actaggtaaa      960

atctacagta caccacaagg gtcacaatac tgttgtgcgc acatcgcggt agggcgtgga     1020

aaggggcagg ccagagctac ccgcagagtt ctcagaatca                           1060


<210>  14
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  15
<211>  640
<212>  DNA
<213>  Homo sapiens

<400>  15
gagggaacgg gtcctggcgg tgctttgcaa agggcccgtg tttctgttgc gggaagctcc       60

cgggggtcgc acgtgcgtcc gagcccaagc ccctcccctc cactcccctt cctgcgtgcc      120

ccggagccgc caagcggcta cgttcttctc ggcccgccga gatggcgctc gaccccgcag      180

accagcatct cagacatgtc gaaaaagatg ttttgatccc taaaataatg agagaaaagg      240

ccaaagagag gtgttctgaa caagttcaag attttaccaa atgttgcaag aactctggag      300

ttcttatggt agtaaaatgc cggaaagaaa attctgcatt gaaagaatgt ctaactgctt      360

actataatga tccagccttt tatgaagaat gcaaaatgga atacctgaag gaaagggaag      420

aattcagaaa aactggaatt cctacaaaga aaaggctaca gaagcttcca acaagcatgt      480

aggcagatac tcaaatgaca ttcaggaact ctaatattca tggaagtcat tttatagtcc      540

ttaaataatg gactcaagca tatatgtttg ctttacctta attatggaaa tattaacttt      600

atctgaaata aatattttat ttcaaaaaaa aaaaaaaaaa                            640


<210>  16
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Leu Asp Pro Ala Asp Gln His Leu Arg His Val Glu Lys Asp 
1               5                   10                  15      


Val Leu Ile Pro Lys Ile Met Arg Glu Lys Ala Lys Glu Arg Cys Ser 
            20                  25                  30          


Glu Gln Val Gln Asp Phe Thr Lys Cys Cys Lys Asn Ser Gly Val Leu 
        35                  40                  45              


Met Val Val Lys Cys Arg Lys Glu Asn Ser Ala Leu Lys Glu Cys Leu 
    50                  55                  60                  


Thr Ala Tyr Tyr Asn Asp Pro Ala Phe Tyr Glu Glu Cys Lys Met Glu 
65                  70                  75                  80  


Tyr Leu Lys Glu Arg Glu Glu Phe Arg Lys Thr Gly Ile Pro Thr Lys 
                85                  90                  95      


Lys Arg Leu Gln Lys Leu Pro Thr Ser Met 
            100                 105     


<210>  17
<211>  832
<212>  DNA
<213>  Homo sapiens

<400>  17
gcgactgtct ccgccgagcc cccggggcca ggtgtcccgg gcgcgccacg atgcggccgc       60

ggctgtggct cctcctggcc gcgcagctga cagttctcca tggcaactca gtcctccagc      120

agacccctgc atacataaag gtgcaaacca acaagatggt gatgctgtcc tgcgaggcta      180

aaatctccct cagtaacatg cgcatctact ggctgagaca gcgccaggca ccgagcagtg      240

acagtcacca cgagttcctg gccctctggg attccgcaaa agggactatc cacggtgaag      300

aggtggaaca ggagaagata gctgtgtttc gggatgcaag ccggttcatt ctcaatctca      360

caagcgtgaa gccggaagac agtggcatct acttctgcat gatcgtcggg agccccgagc      420

tgaccttcgg gaagggaact cagctgagtg tggttgattt ccttcccacc actgcccagc      480

ccaccaagaa gtccaccctc aagaagagag tgtgccggtt acccaggcca gagacccaga      540

agggcccact ttgtagcccc atcacccttg gcctgctggt ggctggcgtc ctggttctgc      600

tggtttccct gggagtggcc atccacctgt gctgccggcg gaggagagcc cggcttcgtt      660

tcatgaaaca gcctcaaggg gaaggtatat caggaacctt tgtcccccaa tgcctgcatg      720

gatactacag caatactaca acctcacaga agctgcttaa cccatggatc ctgaaaacat      780

aggcaagaag cacaggtcct gatgagtgga tctttactac ttttaccaga tt              832


<210>  18
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe 
        195                 200                 205             


Tyr Lys 
    210 


<210>  19
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  19
ctgccagacc cctgccagac cccagtccac catgatccat ctgggtcaca tcctcttcct       60

gcttttgctc ccagtggctg cagctcagac gaccccagga gagagatcat cactccctgc      120

cttttaccct ggcacttcag gctcctgttc cggatgtggg tccctctctc tgccgctcct      180

ggcaggcctc gtggctgctg atgcggtggc atcgctgctc atcgtggggg cggtgttcct      240

gtgcgcacgc ccacgccgca gccccgccca agaagatggc aaagtctaca tcaacatgcc      300

aggcaggggc tgaccctcct gcagcttgga cctttgactt ctgac                      345


<210>  20
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90              


<210>  21
<211>  337
<212>  DNA
<213>  Homo sapiens

<400>  21
aagcccgaat gatatttcct attcgcctac acaattctcc gatccgtccc taacaaacta       60

ggaggcgtcc ttgccctatt actatccatc ctcatcctag caataatccc catcctccat      120

atatccaaac aacaaagcat aatatttcgc ccactaagcc aatcacttta ttgactccta      180

gccgcagacc tcctcattct aacctgaatc ggaggacaac cagtaagcta cccttttacc      240

atcattggac aagtagcatc cgtactatac ttcacaacaa tcctaatcct aataccaact      300

atctccctaa ttgaaaacaa aatactcaaa tgggcct                               337


<210>  22
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Thr Pro Met Arg Lys Thr Asn Pro Leu Met Lys Leu Ile Asn His 
1               5                   10                  15      


Ser Phe Ile Asp Leu Pro Thr Pro Ser Asn Ile Ser Ala Trp Trp Asn 
            20                  25                  30          


Phe Gly Ser Leu Leu Gly Ala Cys Leu Ile Leu Gln Ile Thr Thr Gly 
        35                  40                  45              


Leu Phe Leu Ala Met His Tyr Ser Pro Asp Ala Ser Thr Ala Phe Ser 
    50                  55                  60                  


Ser Ile Ala His Ile Thr Arg Asp Val Asn Tyr Gly Trp Ile Ile Arg 
65                  70                  75                  80  


Tyr Leu His Ala Asn Gly Ala Ser Met Phe Phe Ile Cys Leu Phe Leu 
                85                  90                  95      


His Ile Gly Arg Gly Leu Tyr Tyr Gly Ser Phe Leu Tyr Ser Glu Thr 
            100                 105                 110         


Trp Asn Ile Gly Ile Ile Leu Leu Leu Ala Thr Met Ala Thr Ala Phe 
        115                 120                 125             


Met Gly Tyr Val Leu Pro Trp Gly Gln Met Ser Phe Trp Gly Ala Thr 
    130                 135                 140                 


Val Ile Thr Asn Leu Leu Ser Ala Ile Pro Tyr Ile Gly Thr Asp Leu 
145                 150                 155                 160 


Val Gln Trp Ile Trp Gly Gly Tyr Ser Val Asp Ser Pro Thr Leu Thr 
                165                 170                 175     


Arg Phe Phe Thr Phe His Phe Ile Leu Pro Phe Ile Ile Ala Ala Leu 
            180                 185                 190         


Ala Thr Leu His Leu Leu Phe Leu His Glu Thr Gly Ser Asn Asn Pro 
        195                 200                 205             


Leu Gly Ile Thr Ser His Ser Asp Lys Ile Thr Phe His Pro Tyr Tyr 
    210                 215                 220                 


Thr Ile Lys Asp Ala Leu Gly Leu Leu Leu Phe Leu Leu Ser Leu Met 
225                 230                 235                 240 


Thr Leu Thr Leu Phe Ser Pro Asp Leu Leu Gly Asp Pro Asp Asn Tyr 
                245                 250                 255     


Thr Leu Ala Asn Pro Leu Asn Thr Pro Pro His Ile Lys Pro Glu Trp 
            260                 265                 270         


Tyr Phe Leu Phe Ala Tyr Thr Ile Leu Arg Ser Val Pro Asn Lys Leu 
        275                 280                 285             


Gly Gly Val Leu Ala Leu Leu Leu Ser Ile Leu Ile Leu Ala Met Ile 
    290                 295                 300                 


Pro Ile Leu His Met Ser Lys Gln Gln Ser Met Met Phe Arg Pro Leu 
305                 310                 315                 320 


Ser Gln Ser Leu Tyr Trp Leu Leu Ala Ala Asp Leu Leu Ile Leu Thr 
                325                 330                 335     


Trp Ile Gly Gly Gln Pro Val Ser Tyr Pro Phe Thr Ile Ile Gly Gln 
            340                 345                 350         


Val Ala Ser Val Leu Tyr Phe Thr Thr Ile Leu Ile Leu Met Pro Thr 
        355                 360                 365             


Ile Ser Leu Ile Glu Asn Lys Met Leu Lys Trp Ala 
    370                 375                 380 


<210>  23
<211>  297
<212>  DNA
<213>  Homo sapiens

<400>  23
atgcccctca tttacataaa tattatacta gcatttacca tctcacttct aggaatacta       60

gtatatcgct cacacctcat atcctcccta ctatgcctag aaggaataat actatcgctg      120

ttcattatag ctactctcat aaccctcaac acccactccc tcttagccaa tattgtgcct      180

attgccatac tagtctttgc cgcctgcgaa gcagcggtgg gcctagccct actagtctca      240

atctccaaca catatggcct agactacgta cataacctaa acctactcca atgctaa         297


<210>  24
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Pro Leu Ile Tyr Met Asn Ile Met Leu Ala Phe Thr Ile Ser Leu 
1               5                   10                  15      


Leu Gly Met Leu Val Tyr Arg Ser His Leu Met Ser Ser Leu Leu Cys 
            20                  25                  30          


Leu Glu Gly Met Met Leu Ser Leu Phe Ile Met Ala Thr Leu Met Thr 
        35                  40                  45              


Leu Asn Thr His Ser Leu Leu Ala Asn Ile Val Pro Ile Ala Met Leu 
    50                  55                  60                  


Val Phe Ala Ala Cys Glu Ala Ala Val Gly Leu Ala Leu Leu Val Ser 
65                  70                  75                  80  


Ile Ser Asn Thr Tyr Gly Leu Asp Tyr Val His Asn Leu Asn Leu Leu 
                85                  90                  95      


Gln Cys 
        


<210>  25
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  25
ggggagatct tagctgaaga tgactgacag tgttatttat tccatgttag agttgcctac       60

ggcaacccaa gcccagaatg actatggacc acagcaaaaa tcttcctctt ccaggccttc      120

ttgttcttgc cttgtggcaa tagctttggg gcttctgact gcagttcttc tgagtgtgct      180

gctataccag tggatcctgt gccagggctc caactactcc acttgtgcca gctgtcctag      240

ctgcccagac cgctggatga aatatggtaa ccattgttat tatttctcag tggaggaaaa      300

ggactggaat tctagtctgg aattctgcct agccagagac tcacacctcc ttgtgataac      360

ggacaatcag gaaatgagcc tgctccaagt tttcctcagt gaggcctttt gctggattgg      420

tctgaggaac aattctggct ggaggtggga agatggatca cctctaaact tctcaaggat      480

ttcttctaat agctttgtgc agacatgcgg tgccatcaac aaaaatggtc ttcaagcctc      540

aagctgtgaa gttcctttac actgggtgtg taagaagtgt ccctttgcag atcaagcttt      600

attctgaaga ataaacctag ctggcatgct ggtgtgtacc tgtagtccta gctatttggg      660

aagctgaggt gggagggtcg cttgagccca ggagtttgag gctgcagtga gctatgattg      720

tgccactgta ctccagcctg ggagatagag caagactcca tctctaaaaa aaaaaaaaaa      780

tgctaatgtg agaatataaa ttgtgggaaa tgagtgaggg caaggtggta cttcctcctt      840

ctgagctctt cacacgtaat gcaaaaaccc ggtcttaact gattttgttt tttttctgag      900

tatgcatata tgtggttgaa tgaaccaatg tgtgattgta tcttttccat tatgtgactg      960

tttgacctgc atattaattt caagatagca gtcaattcga taaggcattt tcatagagga     1020

aagtttacag aaacagttta tgtggttgga tcaccaaatt atcttaggta ctaaggcctc     1080

aaaaataaga aaaactttat tatttctcct cagtagagtt tggacataca taaggagaga     1140

aggtacagtg atgaaggaga ccataattct gtagtgttga tgatcctgga ttataatctt     1200

tttctcttta tctttcatag tttttttaaa aacatggact gtatcttatc taccactata     1260

tcccaaatac ctaagatagt gcttacgttc agtgactatt aaataaataa atggatgaat     1320

taaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      1350


<210>  26
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Thr Asp Ser Val Ile Tyr Ser Met Leu Glu Leu Pro Thr Ala Thr 
1               5                   10                  15      


Gln Ala Gln Asn Asp Tyr Gly Pro Gln Gln Lys Ser Ser Ser Ser Arg 
            20                  25                  30          


Pro Ser Cys Ser Cys Leu Val Ala Ile Ala Leu Gly Leu Leu Thr Ala 
        35                  40                  45              


Val Leu Leu Ser Val Leu Leu Tyr Gln Trp Ile Leu Cys Gln Gly Ser 
    50                  55                  60                  


Asn Tyr Ser Thr Cys Ala Ser Cys Pro Ser Cys Pro Asp Arg Trp Met 
65                  70                  75                  80  


Lys Tyr Gly Asn His Cys Tyr Tyr Phe Ser Val Glu Glu Lys Asp Trp 
                85                  90                  95      


Asn Ser Ser Leu Glu Phe Cys Leu Ala Arg Asp Ser His Leu Leu Val 
            100                 105                 110         


Ile Thr Asp Asn Gln Glu Met Ser Leu Leu Gln Val Phe Leu Ser Glu 
        115                 120                 125             


Ala Phe Cys Trp Ile Gly Leu Arg Asn Asn Ser Gly Trp Arg Trp Glu 
    130                 135                 140                 


Asp Gly Ser Pro Leu Asn Phe Ser Arg Ile Ser Ser Asn Ser Phe Val 
145                 150                 155                 160 


Gln Thr Cys Gly Ala Ile Asn Lys Asn Gly Leu Gln Ala Ser Ser Cys 
                165                 170                 175     


Glu Val Pro Leu His Trp Val Cys Lys Lys Cys Pro Phe Ala Asp Gln 
            180                 185                 190         


Ala Leu Phe 
        195 


<210>  27
<211>  586
<212>  DNA
<213>  Homo sapiens

<400>  27
cttttcctaa cactcacaac aaaactaact aatactaaca tctcagacgc tcaggaaata       60

gaaaccgtct gaactatcct gcccgccatc atcctagtcc tcatcgccct cccatcccta      120

cgcatccttt acataacaga cgaggtcaac gatccctccc ttaccatcaa atcaattggc      180

caccaatggt actgaaccta cgagtacacc gactacggcg gactaatctt caactcctac      240

atacttcccc cattattcct agaaccaggc gacctgcgac tccttgacgt tgacaatcga      300

gtagtactcc cgattgaagc ccccattcgt ataataatta catcacaaga cgtcttgcac      360

tcatgagctg tccccacatt aggcttaaaa acagatgcaa ttcccggacg tctaaaccaa      420

accactttca ccgctacacg accgggggta tactacggtc aatgctctga aatctgtgga      480

gcaaaccaca gtttcatgcc catcgtccta gaattaattc ccctaaaaat ctttgaaata      540

gggcccgtat ttaccctata gcaccccctc taccccctct agagcc                     586


<210>  28
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala His Ala Ala Gln Val Gly Leu Gln Asp Ala Thr Ser Pro Ile 
1               5                   10                  15      


Met Glu Glu Leu Ile Thr Phe His Asp His Ala Leu Met Ile Ile Phe 
            20                  25                  30          


Leu Ile Cys Phe Leu Val Leu Tyr Ala Leu Phe Leu Thr Leu Thr Thr 
        35                  40                  45              


Lys Leu Thr Asn Thr Asn Ile Ser Asp Ala Gln Glu Met Glu Thr Val 
    50                  55                  60                  


Trp Thr Ile Leu Pro Ala Ile Ile Leu Val Leu Ile Ala Leu Pro Ser 
65                  70                  75                  80  


Leu Arg Ile Leu Tyr Met Thr Asp Glu Val Asn Asp Pro Ser Leu Thr 
                85                  90                  95      


Ile Lys Ser Ile Gly His Gln Trp Tyr Trp Thr Tyr Glu Tyr Thr Asp 
            100                 105                 110         


Tyr Gly Gly Leu Ile Phe Asn Ser Tyr Met Leu Pro Pro Leu Phe Leu 
        115                 120                 125             


Glu Pro Gly Asp Leu Arg Leu Leu Asp Val Asp Asn Arg Val Val Leu 
    130                 135                 140                 


Pro Ile Glu Ala Pro Ile Arg Met Met Ile Thr Ser Gln Asp Val Leu 
145                 150                 155                 160 


His Ser Trp Ala Val Pro Thr Leu Gly Leu Lys Thr Asp Ala Ile Pro 
                165                 170                 175     


Gly Arg Leu Asn Gln Thr Thr Phe Thr Ala Thr Arg Pro Gly Val Tyr 
            180                 185                 190         


Tyr Gly Gln Cys Ser Glu Ile Cys Gly Ala Asn His Ser Phe Met Pro 
        195                 200                 205             


Ile Val Leu Glu Leu Ile Pro Leu Lys Ile Phe Glu Met Gly Pro Val 
    210                 215                 220                 


Phe Thr Leu 
225         


<210>  29
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  29
atgaacgaaa atctgttcgc ttcattcatt gcccccacaa tcctaggcct acccgccgca       60

gtactgatca ttctatttcc ccctctattg atccccacct ccaaatatct catcaacaac      120

cgactaatca ccacccaaca atgactaatc aaactaacct caaaacaaat gataaccata      180

cacaacacta aaggacgaac ctgatctctt atactagtat ccttaatcat ttttattgcc      240

acaactaacc tcctcggact cctgcctcac tcatttacac caaccaccca actatctata      300

aacctagcca tggccatccc cttatgagcg ggcacagtga ttataggctt tcgctctaag      360

attaaaaatg ccctagccca cttcttacca caaggcacac ctacacccct tatccccata      420

ctagttatta tcgaaaccat cagcctactc attcaaccaa tagccctggc cgtacgccta      480

accgctaaca ttactgcagg ccacctactc atgcacctaa ttggaagcgc caccctagca      540

atatcaacca ttaaccttcc ctctacactt atcatcttca caattctaat tctactgact      600

atcctagaaa tcgctgtcgc cttaatccaa gcctacgttt tcacacttct agtaagcctc      660

tacctgcacg acaacacata a                                                681


<210>  30
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asn Glu Asn Leu Phe Ala Ser Phe Ile Ala Pro Thr Ile Leu Gly 
1               5                   10                  15      


Leu Pro Ala Ala Val Leu Ile Ile Leu Phe Pro Pro Leu Leu Ile Pro 
            20                  25                  30          


Thr Ser Lys Tyr Leu Ile Asn Asn Arg Leu Ile Thr Thr Gln Gln Trp 
        35                  40                  45              


Leu Ile Lys Leu Thr Ser Lys Gln Met Met Thr Met His Asn Thr Lys 
    50                  55                  60                  


Gly Arg Thr Trp Ser Leu Met Leu Val Ser Leu Ile Ile Phe Ile Ala 
65                  70                  75                  80  


Thr Thr Asn Leu Leu Gly Leu Leu Pro His Ser Phe Thr Pro Thr Thr 
                85                  90                  95      


Gln Leu Ser Met Asn Leu Ala Met Ala Ile Pro Leu Trp Ala Gly Thr 
            100                 105                 110         


Val Ile Met Gly Phe Arg Ser Lys Ile Lys Asn Ala Leu Ala His Phe 
        115                 120                 125             


Leu Pro Gln Gly Thr Pro Thr Pro Leu Ile Pro Met Leu Val Ile Ile 
    130                 135                 140                 


Glu Thr Ile Ser Leu Leu Ile Gln Pro Met Ala Leu Ala Val Arg Leu 
145                 150                 155                 160 


Thr Ala Asn Ile Thr Ala Gly His Leu Leu Met His Leu Ile Gly Ser 
                165                 170                 175     


Ala Thr Leu Ala Met Ser Thr Ile Asn Leu Pro Ser Thr Leu Ile Ile 
            180                 185                 190         


Phe Thr Ile Leu Ile Leu Leu Thr Ile Leu Glu Ile Ala Val Ala Leu 
        195                 200                 205             


Ile Gln Ala Tyr Val Phe Thr Leu Leu Val Ser Leu Tyr Leu His Asp 
    210                 215                 220                 


Asn Thr 
225     


<210>  31
<211>  1137
<212>  DNA
<213>  Homo sapiens

<400>  31
acagccacct cagcatgcag aggaggccca gctgctgaga ggagttgcct gagagtgacc       60

tttgcatctg cctgtccagc cagcatggaa ccaaagcgga tcagagaggg ctaccttgtg      120

aagaagggga gcgtgttcaa tacgtggaaa cccatgtggg ttgtattgtt agaagatgga      180

attgaattct ataagaagaa aagtgacaac agccccaaag gaatgatccc gctgaaaggg      240

agcactctga ctagcccttg tcaagacttt ggcaaaagga tgtttgtgtt taagatcact      300

acgaccaaac agcaggacca cttcttccag gcagccttcc tggaggagag agatgcctgg      360

gttcgggata tcaagaaggc cattaaatgc attgaaggag gccagaaatt tgccaggaaa      420

tctaccagga ggtccattcg actgccagaa accattgact taggtgcctt atatttgtcc      480

atgaaagaca ctgaaaaagg aataaaagaa ctgaatctag agaaggacaa gaagattttt      540

aatcactgct tcacaggtaa ctgcgtcatt gattggctgg tatccaacca gtctgttagg      600

aatcgccagg aaggcctcat gattgcttca tcgctgctca atgaggggta tctgcagcct      660

gctggagaca tgtccaagag tgcagtggat ggaactgctg aaaacccttt cctggacaac      720

cctgatgcct tctactactt tccagacagt gggttcttct gtgaagagaa ttccagtgat      780

gatgatgtga ttctgaaaga agaattcaga ggggtcatta tcaagcaggg atgtttactg      840

aagcaggggc atagaaggaa aaactggaaa gtgaggaagt tcatcttgag agaagaccct      900

gcctacctgc actactatga ccctgctggg gcagaagatc ccctgggagc aattcacttg      960

agaggctgtg tggtgacttc agtggagagc aactcaaatg gcaggaagag tgaggaagag     1020

aacctttttg agatcatcac agcagatgaa gtgcactatt tcttgcaagc agccaccccc     1080

aaggagcgca cagagtggat cagagccatc cagatggcct cccgaactgg gaagtaa        1137


<210>  32
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Pro Lys Arg Ile Arg Glu Gly Tyr Leu Val Lys Lys Gly Ser 
1               5                   10                  15      


Val Phe Asn Thr Trp Lys Pro Met Trp Val Val Leu Leu Glu Asp Gly 
            20                  25                  30          


Ile Glu Phe Tyr Lys Lys Lys Ser Asp Asn Ser Pro Lys Gly Met Ile 
        35                  40                  45              


Pro Leu Lys Gly Ser Thr Leu Thr Ser Pro Cys Gln Asp Phe Gly Lys 
    50                  55                  60                  


Arg Met Phe Val Phe Lys Ile Thr Thr Thr Lys Gln Gln Asp His Phe 
65                  70                  75                  80  


Phe Gln Ala Ala Phe Leu Glu Glu Arg Asp Ala Trp Val Arg Asp Ile 
                85                  90                  95      


Lys Lys Ala Ile Lys Cys Ile Glu Gly Gly Gln Lys Phe Ala Arg Lys 
            100                 105                 110         


Ser Thr Arg Arg Ser Ile Arg Leu Pro Glu Thr Ile Asp Leu Gly Ala 
        115                 120                 125             


Leu Tyr Leu Ser Met Lys Asp Thr Glu Lys Gly Ile Lys Glu Leu Asn 
    130                 135                 140                 


Leu Glu Lys Asp Lys Lys Ile Phe Asn His Cys Phe Thr Gly Asn Cys 
145                 150                 155                 160 


Val Ile Asp Trp Leu Val Ser Asn Gln Ser Val Arg Asn Arg Gln Glu 
                165                 170                 175     


Gly Leu Met Ile Ala Ser Ser Leu Leu Asn Glu Gly Tyr Leu Gln Pro 
            180                 185                 190         


Ala Gly Asp Met Ser Lys Ser Ala Val Asp Gly Thr Ala Glu Asn Pro 
        195                 200                 205             


Phe Leu Asp Asn Pro Asp Ala Phe Tyr Tyr Phe Pro Asp Ser Gly Phe 
    210                 215                 220                 


Phe Cys Glu Glu Asn Ser Ser Asp Asp Asp Val Ile Leu Lys Glu Glu 
225                 230                 235                 240 


Phe Arg Gly Val Ile Ile Lys Gln Gly Cys Leu Leu Lys Gln Gly His 
                245                 250                 255     


Arg Arg Lys Asn Trp Lys Val Arg Lys Phe Ile Leu Arg Glu Asp Pro 
            260                 265                 270         


Ala Tyr Leu His Tyr Tyr Asp Pro Ala Gly Ala Glu Asp Pro Leu Gly 
        275                 280                 285             


Ala Ile His Leu Arg Gly Cys Val Val Thr Ser Val Glu Ser Asn Ser 
    290                 295                 300                 


Asn Gly Arg Lys Ser Glu Glu Glu Asn Leu Phe Glu Ile Ile Thr Ala 
305                 310                 315                 320 


Asp Glu Val His Tyr Phe Leu Gln Ala Ala Thr Pro Lys Glu Arg Thr 
                325                 330                 335     


Glu Trp Ile Arg Ala Ile Gln Met Ala Ser Arg Thr Gly Lys 
            340                 345                 350 


<210>  33
<211>  1339
<212>  DNA
<213>  Homo sapiens

<400>  33
tgcgcggctt cctgcctcca tgccactcca gactgcaccg gcatggcact gactgcccac       60

ccctcctgcc tcctggccct gttggtggca ggcctagccc aaggcatcag aggccccctt      120

agggcccagg acctaggtcc ccagccgcta gagctgaaag aggccttcaa gttgttccag      180

atccagttca accggagtta cctgagccca gaagagcatg ctcaccgcct ggacatcttt      240

gcccacaacc tggcccaggc tcagaggctg caggaggagg acttgggcac agctgagttt      300

ggggtgactc cattcagtga cctcacagag gaggagtttg gccagctcta tggctatcgg      360

agggcagctg gaggggtccc cagcatgggc agagaaataa ggtctgaaga gccagaggag      420

tcagtacctt tcagctgtga ctggcggaag gtggccggcg ccatctcacc catcaaggac      480

cagaaaaact gcaactgctg ctgggccatg gcagcggcag gcaacataga gaccctgtgg      540

cgcatcagtt tctgggattt tgtggacgtc tccgtgcagg aactgctgga ctgtggccgc      600

tgtggggatg gctgccacgg tggcttcgtc tgggacgcgt tcataactgt cctcaacaac      660

agcggcctgg ccagtgaaaa ggactacccg ttccagggca aagtcagagc ccacaggtgc      720

caccccaaga agtaccagaa ggtggcctgg atccaggact tcatcatgct gcagaacaac      780

gagcacagaa ttgcgcagta cctggccact tatggcccca tcaccgtgac catcaacatg      840

aagccccttc agctataccg gaaaggtgtg atcaaggcca cacccaccac ctgtgacccc      900

cagcttgtgg accactctgt cctgctggtg ggttttggca gcgtcaagtc agaggagggg      960

atatgggcag agacagtctc atcgcagtct cagcctcagc ctccacaccc caccccatac     1020

tggatcctga agaactcctg gggggcccaa tggggagaga agggctattt ccggctgcac     1080

cgagggagca atacctgtgg catcaccaag ttcccgctca ctgcccgtgt gcagaaaccg     1140

gatatgaagc cccgagtctc ctgccctccc tgaacccacc tggccccctc agctctgtcc     1200

tgttaggcca actgcctcct tgccagcccc acccccaggt ttttgcccat cctcccaatc     1260

tcaatacagc ctgaataaac caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaa                                                  1339


<210>  34
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Leu Thr Ala His Pro Ser Cys Leu Leu Ala Leu Leu Val Ala 
1               5                   10                  15      


Gly Leu Ala Gln Gly Ile Arg Gly Pro Leu Arg Ala Gln Asp Leu Gly 
            20                  25                  30          


Pro Gln Pro Leu Glu Leu Lys Glu Ala Phe Lys Leu Phe Gln Ile Gln 
        35                  40                  45              


Phe Asn Arg Ser Tyr Leu Ser Pro Glu Glu His Ala His Arg Leu Asp 
    50                  55                  60                  


Ile Phe Ala His Asn Leu Ala Gln Ala Gln Arg Leu Gln Glu Glu Asp 
65                  70                  75                  80  


Leu Gly Thr Ala Glu Phe Gly Val Thr Pro Phe Ser Asp Leu Thr Glu 
                85                  90                  95      


Glu Glu Phe Gly Gln Leu Tyr Gly Tyr Arg Arg Ala Ala Gly Gly Val 
            100                 105                 110         


Pro Ser Met Gly Arg Glu Ile Arg Ser Glu Glu Pro Glu Glu Ser Val 
        115                 120                 125             


Pro Phe Ser Cys Asp Trp Arg Lys Val Ala Ser Ala Ile Ser Pro Ile 
    130                 135                 140                 


Lys Asp Gln Lys Asn Cys Asn Cys Cys Trp Ala Met Ala Ala Ala Gly 
145                 150                 155                 160 


Asn Ile Glu Thr Leu Trp Arg Ile Ser Phe Trp Asp Phe Val Asp Val 
                165                 170                 175     


Ser Val Gln Glu Leu Leu Asp Cys Gly Arg Cys Gly Asp Gly Cys His 
            180                 185                 190         


Gly Gly Phe Val Trp Asp Ala Phe Ile Thr Val Leu Asn Asn Ser Gly 
        195                 200                 205             


Leu Ala Ser Glu Lys Asp Tyr Pro Phe Gln Gly Lys Val Arg Ala His 
    210                 215                 220                 


Arg Cys His Pro Lys Lys Tyr Gln Lys Val Ala Trp Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Met Leu Gln Asn Asn Glu His Arg Ile Ala Gln Tyr Leu Ala Thr 
                245                 250                 255     


Tyr Gly Pro Ile Thr Val Thr Ile Asn Met Lys Pro Leu Gln Leu Tyr 
            260                 265                 270         


Arg Lys Gly Val Ile Lys Ala Thr Pro Thr Thr Cys Asp Pro Gln Leu 
        275                 280                 285             


Val Asp His Ser Val Leu Leu Val Gly Phe Gly Ser Val Lys Ser Glu 
    290                 295                 300                 


Glu Gly Ile Trp Ala Glu Thr Val Ser Ser Gln Ser Gln Pro Gln Pro 
305                 310                 315                 320 


Pro His Pro Thr Pro Tyr Trp Ile Leu Lys Asn Ser Trp Gly Ala Gln 
                325                 330                 335     


Trp Gly Glu Lys Gly Tyr Phe Arg Leu His Arg Gly Ser Asn Thr Cys 
            340                 345                 350         


Gly Ile Thr Lys Phe Pro Leu Thr Ala Arg Val Gln Lys Pro Asp Met 
        355                 360                 365             


Lys Pro Arg Val Ser Cys Pro Pro 
    370                 375     


<210>  35
<211>  895
<212>  DNA
<213>  Homo sapiens

<400>  35
atgcgggtca tggcgccccg aaccctcatc ctgctgctct cgggagccct ggccctgacc       60

gagacctggg cctgctccca ctccatgagg tatttctaca ccgccgtgtc ccggcccggc      120

cgcggagagc cccgcttcat cgcagtgggc tacgtggacg acacgcagtt cgtgcggttc      180

gacagcgacg ccgcgagtcc aagaggggag ccgcgggcgc cgtgggtgga gcaggagggg      240

ccggagtatt gggaccggga gacacagaag tacaagcgcc aggcacaggc tgaccgagtg      300

agcctgcgga acctgcgcgg ctactacaac cagagcgagg ccgggtctca caccctccag      360

aggatgtacg gctgcgacct ggggcccgac gggcgcctcc tccgcgggta tgaccagtcc      420

gcctacgacg gcaaggatta catcgccctg aacgaggacc tgcgctcctg gaccgctgcg      480

gacacggcgg ctcagatcac ccagcgcaag tgggaggcgg cccgtgaggc ggagcagtgg      540

agagcctacc tggagggcac gtgcgtggag tggctccgca gatacctgga gaacgggaag      600

gagacgctgc agcgcgcgga acacccaaag acacacgtga cccaccatcc cgtctctgac      660

catgaggcca ccctgaggtg ctgggccctg ggcttctacc ctgcggagat cacactgacc      720

tggcagcggg atggcgagga ccaaactcag gacaccgagc ttgtggagac caggccagca      780

ggagatggaa ccttccagaa gtgggcagct gtggtggtgc cttctggaga agagcagaga      840

tacacgtgcc atgtgcagca cgaggggctg ccagagcccc tcaccctgag atggg           895


<210>  36
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Arg Val Met Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Trp Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu His 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Met Ala Val Val Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Ser Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Ala Cys Lys Ala 
        355                 360                 365     


<210>  37
<211>  1512
<212>  DNA
<213>  Homo sapiens

<400>  37
gcctgagagg caggtagctg cggcgctggg ctggcggcgg cgagtccacg tgctccccgc       60

ggccggttga aaccgttggc gggcgctggc tgagaggcaa tgtttgctgt cttccattgg      120

agtgactgaa tttctacatg acggcttttt gacaagactt aaaacctgtc ttggatagag      180

aatatttagc catttaccta aaaatggtat tttttacatg caatgcatgt ggtgaatcag      240

tgaagaaaat acaagtggaa aagcatgtgt ctgtttgcag aaactgtgaa tgcctttctt      300

gcattgactg cggtaaagat ttctggggcg atgactataa aaaccacgtg aaatgcataa      360

gtgaagatca gaagtatggt ggcaaaggct atgaaggtaa aacccacaaa ggcgacatca      420

aacagcaggc gtggattcag aaaattagtg aattaataaa gagacccaat gtcagcccca      480

aagtgagaga acttttagag caaattagtg cttttgacaa cgttcccagg aaaaaggcaa      540

aatttcagaa ttggatgaag aacagtttaa aagttcataa tgaatccatt ctggaccagg      600

tgtggaatat cttttctgaa gcttccaaca gcgaaccagt caataaggaa caggatcaac      660

ggccactcca cccagtggca aatccacatg cagaaatctc caccaaggtt ccagcctcca      720

aagtgaaaga cgccgtggaa cagcaagggg aggtgaagaa gaataaaaga gaaagaaagg      780

aagaacggca gaagaaaagg aaaagagaaa agaaagaact aaagttagaa aaccaccagg      840

aaaactcaag gaatcagaag cctaagaagc gcaaaaaggg acaggaggct gaccttgagg      900

ctggtgggga ggaagtccct gaggccaatg gctctgcagg gaagaggagc aagaagaaga      960

agcagcgcaa ggacagcgcc agtgaggaag aggcacgcgt gggcgcaggg aagaggaagc     1020

ggaggcactc ggaagttgaa acagattcta agaagaaaaa gatgaagctc ccagagcatc     1080

ctgagggcgg agaaccagaa gacgatgagg ctcctgcaaa aggtaaattc aactggaagg     1140

gaactattaa agcaattctg aaacaggccc cagacaatga aataaccatc aaaaagctaa     1200

ggaaaaaggt tttagctcag tactacacag tgacagatga gcatcacaga tccgaagagg     1260

aactcctggt catctttaac aagaaaatca gcaagaaccc tacctttaag ttattaaagg     1320

acaaagtcaa gcttgtgaaa tgaacatttg tgtatttaaa aattgaatcc attctgctga     1380

cttcttcctt tcactgctgt ttataaaatg tgtaatgaat tctaacaact caaattttgc     1440

tttttgaagc tgtattttta agttaagaaa aaatatattt ttggtataac ttttatgaaa     1500

aaaaaaaaaa aa                                                         1512


<210>  38
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Val Phe Phe Thr Cys Asn Ala Cys Gly Glu Ser Val Lys Lys Ile 
1               5                   10                  15      


Gln Val Glu Lys His Val Ser Val Cys Arg Asn Cys Glu Cys Leu Ser 
            20                  25                  30          


Cys Ile Asp Cys Gly Lys Asp Phe Trp Gly Asp Asp Tyr Lys Asn His 
        35                  40                  45              


Val Lys Cys Ile Ser Glu Asp Gln Lys Tyr Gly Gly Lys Gly Tyr Glu 
    50                  55                  60                  


Gly Lys Thr His Lys Gly Asp Ile Lys Gln Gln Ala Trp Ile Gln Lys 
65                  70                  75                  80  


Ile Ser Glu Leu Ile Lys Arg Pro Asn Val Ser Pro Lys Val Arg Glu 
                85                  90                  95      


Leu Leu Glu Gln Ile Ser Ala Phe Asp Asn Val Pro Arg Lys Lys Ala 
            100                 105                 110         


Lys Phe Gln Asn Trp Met Lys Asn Ser Leu Lys Val His Asn Glu Ser 
        115                 120                 125             


Ile Leu Asp Gln Val Trp Asn Ile Phe Ser Glu Ala Ser Asn Ser Glu 
    130                 135                 140                 


Pro Val Asn Lys Glu Gln Asp Gln Arg Pro Leu His Pro Val Ala Asn 
145                 150                 155                 160 


Pro His Ala Glu Ile Ser Thr Lys Val Pro Ala Ser Lys Val Lys Asp 
                165                 170                 175     


Ala Val Glu Gln Gln Gly Glu Val Lys Lys Asn Lys Arg Glu Arg Lys 
            180                 185                 190         


Glu Glu Arg Gln Lys Lys Arg Lys Arg Glu Lys Lys Glu Leu Lys Leu 
        195                 200                 205             


Glu Asn His Gln Glu Asn Ser Arg Asn Gln Lys Pro Lys Lys Arg Lys 
    210                 215                 220                 


Lys Gly Gln Glu Ala Asp Leu Glu Ala Gly Gly Glu Glu Val Pro Glu 
225                 230                 235                 240 


Ala Asn Gly Ser Ala Gly Lys Arg Ser Lys Lys Lys Lys Gln Arg Lys 
                245                 250                 255     


Asp Ser Ala Ser Glu Glu Glu Ala His Val Gly Ala Gly Lys Arg Lys 
            260                 265                 270         


Arg Arg His Ser Glu Val Glu Thr Asp Ser Lys Lys Lys Lys Met Lys 
        275                 280                 285             


Leu Pro Glu His Pro Glu Gly Gly Glu Pro Glu Asp Asp Glu Ala Pro 
    290                 295                 300                 


Ala Lys Gly Lys Phe Asn Trp Lys Gly Thr Ile Lys Ala Ile Leu Lys 
305                 310                 315                 320 


Gln Ala Pro Asp Asn Glu Ile Thr Ile Lys Lys Leu Arg Lys Lys Val 
                325                 330                 335     


Leu Ala Gln Tyr Tyr Thr Val Thr Asp Glu His His Arg Ser Glu Glu 
            340                 345                 350         


Glu Leu Leu Val Ile Phe Asn Lys Lys Ile Ser Lys Asn Pro Thr Phe 
        355                 360                 365             


Lys Leu Leu Lys Asp Lys Val Lys Leu Val Lys 
    370                 375                 


<210>  39
<211>  2294
<212>  DNA
<213>  Homo sapiens

<400>  39
ccttttctcg gggcgcccga gaggccagct cagacctccc ggctcgacag gcggcgcggg       60

cggcggtaaa atgtcggttc caggacctta ccaggcggcc actgggcctt cctcagcacc      120

atccgcacct ccatcctatg aagagacagt ggctgttaac agttattacc ccacacctcc      180

agctcccatg cctgggccaa ctacggggct tgtgacgggg cctgatggga agggcatgaa      240

tcctccttcg tattataccc agccagcgcc catccccaat aacaatccaa ttaccgtgca      300

gacggtctac gtgcagcacc ccatcacctt tttggaccgc cctatccaaa tgtgttgtcc      360

ttcctgcaac aagatgatcg tgagtcagct gtcctataac gccggtgctc tgacctggct      420

gtcctgcggg agcctgtgcc tgctggggca ggagtgcagt ggtacgatcg tagctctccg      480

cagctttgat ctcctgggct cctgcaatcc gcccagctca gcctcctgag tacctgggac      540

cacaggtgca tagcgggctg ctgcttcatc cccttctgcg tggatgccct gcaggacgtg      600

gaccattact gtcccaactg cagagctctc ctgggcacct acaagcgttt gtaggactca      660

gccagacgtg gagggagccg ggtgccgcag gaagtccttt ccacctctca tccagcttca      720

cgcctggtgg aggttctgcc ctggtggtct cacctctcca gggggcccac cttcatgtct      780

tcttttgggg ggaatacgtc gcaaaactaa caaatctcca aaccccagaa attgctgctt      840

ggagtcgtgc ataggacttg caaagacatt ccccttgagt gtcagttcca cggtttcctg      900

cctccctgag accctgagtc ctgccatcta actgtgatca ttgccctatc cgaatatctt      960

cctgtgatct gccatcagtg gctctttttt cctgcttcca tgggcctttc tggtggcagt     1020

ctcaaactga gaagccacag ttgccttatt tttgaggctg ttctgcccag agctcggctg     1080

aaccagcctt tagtgcctac cattatctta tccgtctctt cccgtccctg atgacaaaga     1140

tcttgcctta cagactttac aggcttggct ttgagattct gtaactgcag acttcattag     1200

cacacagatt cactttaatt tcttaatttt ttttttttaa atacaaggag ggggctatta     1260

acacccagta cagacatatc cacaaggtcg taaatgcatg ctagaaaaat agggctggat     1320

cttatcactg ccctgtctcc ccttgtttct ctgtgccaga tcttcagtgc ccctttccat     1380

acagggattt ttttctcata gagtaattat atgaacagtt tttatgacct ccttttggtc     1440

tgaaatactt ttgaacagaa tttctttttt ttaaaaaaaa acagagatgg ggtcttacta     1500

tgttgcccag gctggtgtcg aactcctggg ctcaagcgat ccttctgcct tggcctcccg     1560

aagtgctggg attgcaggca taagctacca tgctgggcct gaacataatt tcaagaggag     1620

gatttataaa accattttct gtaatcaaat gattggtgtc attttcccat ttgccaatgt     1680

agtctcactt aaaaaaaaaa aaaagaaaaa gaaatggata atttcatcta ctgcctttac     1740

ttggggttaa tgtgattctt aaacaccttc atcatggaac tctcagagtg gggtccgttt     1800

tggtttcctg gtggtgggtt ttgaaagata agggaaagca cattttgagc atgtctgggt     1860

accatggtgc ggatgcttgg gaaccagaac tgtttcagag gaatctgaag tctgatttta     1920

gttttcagag acacagcttg ttgtaaaaca tgagaagaca tgatttctag gactcaagca     1980

gcaagccagg attctaggtt ggctgctgtg tcatctttga agtcaagaca aagctgggct     2040

cgaccttcaa gggtcctcgt tttgataata cttcagaata gggaactcat gtgaatacta     2100

ctatgtagaa ataaaaccta gaccttgagc gaacatctgt atattggttg aaaacgatag     2160

tggtaaccat tgatccccct tcatttgatg tttggaaaat tccagtaatt atcatttttg     2220

caacgaatat ggataccaca tagtactttg gtgttacctg cttttgaaaa ataaagtctt     2280

tggttcaccc ggtg                                                       2294


<210>  40
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Val Pro Gly Pro Tyr Gln Ala Ala Thr Gly Pro Ser Ser Ala 
1               5                   10                  15      


Pro Ser Ala Pro Pro Ser Tyr Glu Glu Thr Val Ala Val Asn Ser Tyr 
            20                  25                  30          


Tyr Pro Thr Pro Pro Ala Pro Met Pro Gly Pro Thr Thr Gly Leu Val 
        35                  40                  45              


Thr Gly Pro Asp Gly Lys Gly Met Asn Pro Pro Ser Tyr Tyr Thr Gln 
    50                  55                  60                  


Pro Ala Pro Ile Pro Asn Asn Asn Pro Ile Thr Val Gln Thr Val Tyr 
65                  70                  75                  80  


Val Gln His Pro Ile Thr Phe Leu Asp Arg Pro Ile Gln Met Cys Cys 
                85                  90                  95      


Pro Ser Cys Asn Lys Met Ile Val Ser Gln Leu Ser Tyr Asn Ala Gly 
            100                 105                 110         


Ala Leu Thr Trp Leu Ser Cys Gly Ser Leu Cys Leu Leu Gly Cys Ile 
        115                 120                 125             


Ala Gly Cys Cys Phe Ile Pro Phe Cys Val Asp Ala Leu Gln Asp Val 
    130                 135                 140                 


Asp His Tyr Cys Pro Asn Cys Arg Ala Leu Leu Gly Thr Tyr Lys Arg 
145                 150                 155                 160 


Leu 
    


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Gly Phe Thr Phe Ser Asp Ser Trp Ile His 
1               5                   10  


<210>  42
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  47
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  48
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  49
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  50
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  51
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  52
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  53
<211>  3393
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2042)..(2042)
<223>  n is a, c, g, or t

<400>  53
ctgtggtgat gatgtggtca ctgcatgatt ctcacacaag cacccagagg acgtcatcag       60

gcagaggcag tgggggtggg cagcatttac agaaaatctg tgatgagaca ccacaaaacc      120

agaggggaac atgaagtcac tgagcctgct ccacctcttt cctctcccaa gagctaaaag      180

agagcaagga ggaaacaaca gcagctccaa ccagggcagc cttcctgaga agatgcaacc      240

aatcctgctt ctgctggcct tcctcctgct gcccagggca gatgcaggtg agtgaccgtc      300

tccaccctcg ggggcccaac ccgatcccac aggtctcctg ccctttctcc acattcctga      360

tccatctatc taccaggaat gttctgaact ccagctccca ttctaaccaa gaccccccaa      420

gtgtgatgct ggataagcta tcagcaggaa tcggagagca gcaggcgatt ctcaagaaga      480

gccagtgggt actacccttc cccagagccc acctttgtca cctggagaga ggactttcct      540

agaagtaaat ggcagaggat gggaaactag aaaattctgt ttctgggata agacaggtgc      600

ttctctcact gtctgctaag gagggaaacc cagctgacag cagaattggt acaatcactg      660

tcctcagaac actgttaatg tgtttgctca gtcccattct ccaactctgc ttttcttccc      720

tggcctttgg tggctcccct ctttccaagg atgaggcact acggcaggcc ccagcttccc      780

tgctttctag aattccacca gcactgctct accagccctc atccagaggc taactggagc      840

cagtccatca tgcagccatg aacatttact gggcacccac tacatgtcag gctctaggaa      900

acaggatatg acagtatcta gatccctcca cttacacctg gccattagaa agcagcacta      960

tcctagacac cacaggactc ataagggtct tggaaactca cctgaaacaa agcaaagtca     1020

ggagaggaat gatcaggagc ctctgggatt tcactgtccc taagacaggt atgctcgcct     1080

tcaactacat atggaagaaa gatttacaca gaccaaagtc tgctgttctt ccctttttca     1140

gagcaggaaa ttgaagcccc ttcctccagg ccactcccaa ctccaggcta tcccaggctc     1200

ccaaatgccc aggagttctg gagccactaa gcaggtgccc acccaggaga ttccatgggt     1260

gcccacaagc agacagactt ttccttcagg ggagatcatc gggggacatg aggccaagcc     1320

ccactcccgc ccctacatgg cttatcttat gatctgggat cagaagtctc tgaagaggtg     1380

cggtggcttc ctgatacaag acgacttcgt gctgacagct gctcactgtt ggggaaggtg     1440

aggagcagaa aacagcccac accctcctgg aaacactcca cagagacccc tgccttcttc     1500

ccaaggagct ccctgggctc ctgtgaacac acatgccagg aggtctcctt agagggtgag     1560

aaaagggcag ttaagtttgt ggagagaggg gaaggttggt tccagaggtg ctgctgaggt     1620

aagaaacagc agagtgacca agcctgccat atttagaact gggggcatac tttggcatag     1680

aatacaaact gaagcaattc cacctgtgtt tctaggggga accgaaccct gagaaacctg     1740

gtgcaattac cgagattcca attccttggg gaccgactgt ccccttaatt tcccctcagc     1800

tgcagccctg ccccagctgt cacctgctct tcactgctct tcactgtctc tgggctgtat     1860

accctgtgac tccaccccca tcctcactct gctctctctg cagctccata aatgtcacct     1920

tgggggccca caatatcaaa gaacaggagc cgacccagca gtttatccct gtgaaaagac     1980

ccatccccca tccagcctat aatcctaaga acttctccaa cgacatcatg ctactgcagg     2040

tnaggcacac tcctgccact cttgctcttc ttggtccagt tggttccact ccccctgaga     2100

tgccggccct tccctccttt ccatcctggc ctcttggtct agttcctatg cctcagagga     2160

gagggaagat tgtgcagccc catcactgtg tcggggccca gaagttcgtt ggctgacctg     2220

gactttcttg cctcttcccc caccagctgg agagaaaggc caagcggacc agagctgtgc     2280

agcccctcag gctacctagc aacaaggccc aggtgaagcc agggcagaca tgcagtgtgg     2340

ccggctgggg gcagacggcc cccctgggaa aacactcaca cacactacaa gaggtgaaga     2400

tgacagtgca ggaagatcga aagtgcgaat ctgacttacg ccattattac gacagtacca     2460

ttgagttgtg cgtgggggac ccagagatta aaaagacttc ctttaaggta agactatgca     2520

cctgcctgga ttggctcttg ggagaaagat ctttggggaa tatctgagac ctggagactc     2580

aagtagtggg ggactccttc acccactaga ctgtgatatt tctctctgga aagagaagag     2640

gggactagac tgagctgggg agaaattagg gcctctgcaa acttaccagg aggcttatgg     2700

tggatggtgc ttctttggaa ggatgaattt gcaacactcc acccactcca ggtcacagat     2760

attaggaaac tgtgcccact gggggtgcag taattataac caggtgtgtc ttcagaggct     2820

ggtacccaac gtgaatgggc tggtcctcca tggtggacat cagccctcct tgcccacttc     2880

tgggtcctta aacagccaac ggtcccacat acctccgatc tcaggatctg ggggacatga     2940

cggaggctgg cccctgggat gaggtgaagc agtaacaatg tccagggcca gagcttggca     3000

gctgggggcc accagcggcc tgccctgccc tctggtctcc cacatgtagg ctgtgcaagt     3060

tggccttttc taaaaggggg cttgagatgg aagagagggc aggacccgga ggagcatcag     3120

ctcagtcctt ccactctcta ttcacagggg gactctggag gccctcttgt gtgtaacaag     3180

tgtgcccagg gcattgtctc ctatggacga aacaatggca tgcctccacg agcctgcacc     3240

aaagtctcaa gctttgtaca ctggataaag aaaaccatga aacgctacta actacaggaa     3300

agcaactaag cccccgctgt aatgaaacac cttctctgga gccaagtcca gatttacact     3360

gggagaggtg ccagcaactg aataaatact ctt                                  3393


<210>  54
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys 
65                  70                  75                  80  


Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro 
                85                  90                  95      


His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg 
        115                 120                 125             


Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val 
    130                 135                 140                 


Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu 
145                 150                 155                 160 


Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp 
                165                 170                 175     


Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro 
            180                 185                 190         


Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly 
    210                 215                 220                 


Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile 
225                 230                 235                 240 


Lys Lys Thr Met Lys Arg Tyr 
                245         


<210>  55
<211>  596
<212>  DNA
<213>  Homo sapiens

<400>  55
ctacttcgct cttggaacat aatttctcat ggcagtgttt aagaccactc tgtggaggtt       60

aatttctggg accttaggga taatatgcct ttcgttgatg gctacgttgg gaattttgtt      120

gaaaaattct tttactaaac tgagtattga gccagcattt actccaggac ccaacataga      180

actccagaaa gactctgact gctgttcttg ccaagaaaaa tgggttgggt accggtgcaa      240

ctgttacttc atttccagtg aacagaaaac ttggaacgaa agtcggcatc tctgtgcttc      300

tcagaaatcc agcctgcttc agcttcaaaa cacagatgaa ctgcaggatt ttatgagctc      360

cagtcaacaa ttttactgga ttggactctc ttacagtgag gagcacaccg cctggttgtg      420

ggagaatggc tctgcactct cccagtatct atttccatca tttgaaactt ttaatacaaa      480

gaactgcata gcgtataatc caaatggaaa tgctttagat gaatcctgtg aagataaaaa      540

tcgttatatc tgtaagcaac agctcattta aatgtttctt ggggcagaga aggtgg          596


<210>  56
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Val Phe Lys Thr Thr Leu Trp Arg Leu Ile Ser Gly Thr Leu 
1               5                   10                  15      


Gly Ile Ile Cys Leu Ser Leu Met Ser Thr Leu Gly Ile Leu Leu Lys 
            20                  25                  30          


Asn Ser Phe Thr Lys Leu Ser Ile Glu Pro Ala Phe Thr Pro Gly Pro 
        35                  40                  45              


Asn Ile Glu Leu Gln Lys Asp Ser Asp Cys Cys Ser Cys Gln Glu Lys 
    50                  55                  60                  


Trp Val Gly Tyr Arg Cys Asn Cys Tyr Phe Ile Ser Ser Glu Gln Lys 
65                  70                  75                  80  


Thr Trp Asn Glu Ser Arg His Leu Cys Ala Ser Gln Lys Ser Ser Leu 
                85                  90                  95      


Leu Gln Leu Gln Asn Thr Asp Glu Leu Asp Phe Met Ser Ser Ser Gln 
            100                 105                 110         


Gln Phe Tyr Trp Ile Gly Leu Ser Tyr Ser Glu Glu His Thr Ala Trp 
        115                 120                 125             


Leu Trp Glu Asn Gly Ser Ala Leu Ser Gln Tyr Leu Phe Pro Ser Phe 
    130                 135                 140                 


Glu Thr Phe Asn Thr Lys Asn Cys Ile Ala Tyr Asn Pro Asn Gly Asn 
145                 150                 155                 160 


Ala Leu Asp Glu Ser Cys Glu Asp Lys Asn Arg Tyr Ile Cys Lys Gln 
                165                 170                 175     


Gln Leu Ile 
            


<210>  57
<211>  1199
<212>  DNA
<213>  Homo sapiens

<400>  57
ctttaaaggg tgactcgtcc cacttgtgtt ctctctcctg gtgcagagtt gcaagcaagt       60

ttatcggagt atcgccatga agttcgtccc ctgcctcctg ctggtgacct tgtcctgcct      120

ggggactttg ggtcaggccc cgaggcaaaa gcaaggaagc actggggagg aattccattt      180

ccagactgga gggagagatt cctgcactat gcgtcccagc agcttggggc aaggtgctgg      240

agaagtctgg cttcgcgtcg actgccgcaa cacagaccag acctactggt gtgagtacag      300

ggggcagccc agcatgtgcc aggcttttgc tgctgacccc aaaccttact ggaatcaagc      360

cctgcaggag ctgaggcgcc ttcaccatgc gtgccagggg gccccggtgc ttaggccatc      420

cgtgtgcagg gaggctggac cccaggccca tatgcagcag gtgacttcca gcctcaaggg      480

cagcccagag cccaaccagc agcctgaggc tgggacgcca tctctgaggc ccaaggccac      540

agtgaaactc acagaagcaa cacagctggg aaaggactcg atggaagagc tgggaaaagc      600

caaacccacc acccgaccca cagccaaacc tacccagcct ggacccaggc ccggagggaa      660

tgaggaagca aagaagaagg cctgggaaca ttgttggaaa cccttccagg ccctgtgcgc      720

ctttctcatc agcttcttcc gagggtgaca ggtgaaagac ccctacagat ctgacctctc      780

cctgacagac aaccatctct ttttatatta tgccgctttc aatccaacgt tctcacactg      840

gaagaagaga gtttctaatc agatgcaacg gcccaaattc ttgatctgca gcttctctga      900

agtttggaaa agaaaccttc ctttctggag tttgcagagt tcagcaatat gatagggaac      960

aggtgctgat gggcccaaga gtgacaagca tacacaacta cttattatct gtagaagttt     1020

tgctttgttg atctgagcct tctatgaaag tttaaatatg taacgcattc atgaatttcc     1080

agtgttcagt aaatagcagc tatgtgtgtg caaaataaaa gaatgatttc agaaataaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      1199


<210>  58
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Lys Phe Val Pro Cys Leu Leu Leu Val Thr Leu Ser Cys Leu Gly 
1               5                   10                  15      


Thr Leu Gly Gln Ala Pro Arg Gln Lys Gln Gly Ser Thr Gly Glu Glu 
            20                  25                  30          


Phe His Phe Gln Thr Gly Gly Arg Asp Ser Cys Thr Met Arg Pro Ser 
        35                  40                  45              


Ser Leu Gly Gln Gly Ala Gly Glu Val Trp Leu Arg Val Asp Cys Arg 
    50                  55                  60                  


Asn Thr Asp Gln Thr Tyr Trp Cys Glu Tyr Arg Gly Gln Pro Ser Met 
65                  70                  75                  80  


Cys Gln Ala Phe Ala Ala Asp Pro Lys Pro Tyr Trp Asn Gln Ala Leu 
                85                  90                  95      


Gln Glu Leu Arg Arg Leu His His Ala Cys Gln Gly Ala Pro Val Leu 
            100                 105                 110         


Arg Pro Ser Val Cys Arg Glu Ala Gly Pro Gln Ala His Met Gln Gln 
        115                 120                 125             


Val Thr Ser Ser Leu Lys Gly Ser Pro Glu Pro Asn Gln Gln Pro Glu 
    130                 135                 140                 


Ala Gly Thr Pro Ser Leu Arg Pro Lys Ala Thr Val Lys Leu Thr Glu 
145                 150                 155                 160 


Ala Thr Gln Leu Gly Lys Asp Ser Met Glu Glu Leu Gly Lys Ala Lys 
                165                 170                 175     


Pro Thr Thr Arg Pro Thr Ala Lys Pro Thr Gln Pro Gly Pro Arg Pro 
            180                 185                 190         


Gly Gly Asn Glu Glu Ala Lys Lys Lys Ala Trp Glu His Cys Trp Lys 
        195                 200                 205             


Pro Phe Gln Ala Leu Cys Ala Phe Leu Ile Ser Phe Phe Arg Gly 
    210                 215                 220             


<210>  59
<211>  1947
<212>  DNA
<213>  Homo sapiens

<400>  59
agaataaaaa acatttgcca agacctcatg cccttttagt aaacgaatgt ttactgccac       60

ctccagagaa gctcactgct gaggtcctag gaatcatttg cattgtcctg atggccactg      120

tgttaaaaac aatagttctt attccttgta ttggagtact ggagcagaac aatttttccc      180

tgaatagaag aatgcagaaa gcacgtcatt gtggccattg tcctgaggag tggattacat      240

attccaacag ttgttattac attggtaagg aaagaagaac ttgggaagaa agagtttgct      300

ggcctgtgct tcgaagaact ctgatctgct ttctatagat aatgaggaag aaatgctact      360

ggggataaag gaaggagaaa taagtcaact aaaatttgag cacctgctaa taggtatgtg      420

tggggacttc ccagttggct gtaagttgcc atttgaacta aacgaaatag gaatcctttg      480

tgcattgaag actttagatt cctctctgcg gtagacgtgc acttataagt atttgatggg      540

gtggattcgt ggtcggaggt ctcgacacag ctgggagatg agtgaatttc ataattataa      600

cttggatctg aagaagagtg atttttcaac acgatggcaa aagcaaagat gtccagtagt      660

caaaagcaaa tgtagagaaa atgcatctcc attttttttc tgctgcttca tcgctgtagc      720

catgggaatc cgtttcatta ttatggtaac aatatggagt gctgtattcc taaactcatt      780

attcaaccaa gaagttcaaa ttcccttgac cgaaagttac tgtggcccat gtcctaaaaa      840

ctggatatgt tacaaaaata actgctacca attttttgat gagagtaaaa actggtatga      900

gagccaggct tcttgtatgt ctcaaaatgc cagccttctg aaagtataca gcaaagagga      960

ccaggattta cttaaactgg tgaagtcata tcattggatg ggactagtac acattccaac     1020

aaatggatct tggcagtggg aagatggctc cattctctca cccaacctac taacaataat     1080

tgaaatgcag aagggagact gtgcactcta tgcctcgagc tttaaaggct atatagaaaa     1140

ctgttcaact ccaaatacgt acatctgcat gcaaaggact gtgtaaagat gatcaaccat     1200

ctcaataaaa gccaggaaca gagaagagat tacaccagcg gtaacactgc caactgagac     1260

taaaggaaac aaacaaaaac aggacaaaat gaccaaagac tgtcagattt cttagactcc     1320

acaggaccaa accatagaac aatttcactg caaacatgca tgattctcca agacaaaaga     1380

agagagatcc taaaggcaat tcagatatcc ccaaggctgc ctctcccacc acaagcccag     1440

agtggatggg ctgggggagg ggtgctgttt taatttctaa aggtaggacc aacacccagg     1500

ggatcagtga aggaagagaa ggccagcaga tcactgagag tgcaacccca ccctccacag     1560

gaaattgcct catgggcagg gccacagcag agagacacag catgggcagt gccttccctg     1620

cctgtggggg tcatgctgcc acttttaatg ggtcctccac ccaacggggt cagggaggtg     1680

gtgctgcccc agtgggccat gattatctta aaggcattat tctccagcct taagtaagat     1740

cttaggacgt ttcctttgct atgatttgta cttgcttgag tcccatgact gtttctcttc     1800

ctctctttct tccttttgga atagtaatat ccatcctatg tttgtcccac tattgtattt     1860

tggaagcaca taacttgttt ggtttcacag gttcacagtt aagaaggaat tttgcctctg     1920

aataaataga atcttgagtc tcatgca                                         1947


<210>  60
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  60

Glu Val Ser Leu Ala Gln Asp Pro Lys Arg Gln Gln Arg Lys Leu Lys 
1               5                   10                  15      


Gly Asn Lys Ile Ser Ile Ser Gly Thr Lys Gln Glu Ile Phe Gln Val 
            20                  25                  30          


Glu Leu Asn Leu Gln Asn Ala Ser Ser Asp His Gln Gly Asn Asp Lys 
        35                  40                  45              


Thr Tyr His Cys Lys Gly Leu Leu Pro Pro Pro Glu Lys Leu Thr Ala 
    50                  55                  60                  


Glu Val Leu Gly Ile Ile Cys Ile Val Leu Met Ala Thr Val Leu Lys 
65                  70                  75                  80  


Thr Ile Val Leu Ile Pro Cys Ile Gly Val Leu Glu Gln Asn Asn Phe 
                85                  90                  95      


Ser Leu Asn Arg Arg Met Gln Lys Ala Arg His Cys Gly His Cys Pro 
            100                 105                 110         


Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys Tyr Tyr Ile Gly Lys Glu 
        115                 120                 125             


Arg Arg Thr Trp Glu Glu Arg Val Cys Trp Pro Val Leu Arg Arg Thr 
    130                 135                 140                 


Leu Ile Cys Phe Leu 
145                 


<210>  61
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  61
atggggtgga ttcgtggtcg gaggtctcga cacagctggg agatgagtga atttcataat       60

tataacttgg atctgaagaa gagtgatttt tcaacacgat ggcaaaagca aagatgtcca      120

gtagtcaaaa gcaaatgtag agaaaatgca tctccatttt ttttctgctg cttcatcgct      180

gtagccatgg gaatccgttt cattattatg gtaacaatat ggagtgctgt attcctaaac      240

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct      300

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg      360

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa      420

gaggaccagg atttacttaa actggtgaag tcatatcatt ggatgggact agtacacatt      480

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca      540

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata      600

gaaaactgtt caactccaaa tacgtacatc tgcatgcaaa ggactgtgta a               651


<210>  62
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  63
<211>  1397
<212>  DNA
<213>  Homo sapiens

<400>  63
gcagacgctc ggcaggtgtc ttgatatatc atctgctgaa gggtgaagct gaagggtgaa       60

agggaagtga gctgacgctc gaaaggtgtc ttgagattat catccgctga cggtgaaagc      120

ggaacccgca gatgctcagc aggtatcttg atattatcat ctgctgaggg tgaagctgag      180

ggtggaaggg gagtgagctg acgctcggaa ggtctcttga gattatcatc cgctgagggt      240

ggaagcggaa ctgcagatgc tcggcaggtg tcttgatatt atcatctgct gagggtggag      300

ctgagggtgg aaggggagtg agctgacgct cggaaggtgt cttgagatta tcatccgctg      360

agggtggaag cggcccccgc agatgctcgg cagttgtctt gatattatca tctgctgagg      420

gtggagctga gggtggaagg ggagtgagct gacgctcgga aggtgtcttg agattatcat      480

ccgctgaggg tggaagggga tggagcagac actcggcacg tgtcttgaga ttatcatccg      540

ctgagggtgg agctgagggt ggagctgagg gtggaagggg agtgagcaga cactcgggag      600

gtgtcttgag attatcatcc gctgagggtg gaaggggagt gagcagacac tcgggaggtg      660

tcttgaggct cagggagtta tcagttatac aatgttgttg agttggagga ggtggctggt      720

ggcccatcct gttttttaaa gtttcagctg tgaggtagag ccagtagggc attcctgaag      780

ctgacagcat tcgggccgag atgtctcgct ccgtggcctt agctgtgctc gcgctactct      840

ctctttctgg cctggaggct atccagcgta ctccaaagat tcaggtttac tcacgtcatc      900

cagcagagaa tggaaagtca aatttcctga attgctatgt gtctgggttt catccatccg      960

acattgaagt tgacttactg aagaatggag agagaattga aaaagtggag cattcagact     1020

tgtctttcag caaggactgg tctttctatc tcttgtacta cactgaattc acccccactg     1080

aaaaagatga gtatgcctgc cgtgtgaacc atgtgacttt gtcacagccc aagatagtta     1140

agtgggatcg agacatgtaa gcagcatcat ggaggtttga agatgccgca tttggattgg     1200

atgaattcca aattctgctt gcttgctttt taatattgat atgcttatac acttacactt     1260

tatgcacaaa atgtagggtt ataataatgt taacatggac atgatcttct ttataattct     1320

actttgagtg ctgtctccat gtttgatgta tctgagcagg ttgctccaca ggtagctcta     1380

gcagggctgg caactta                                                    1397


<210>  64
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  65
<211>  884
<212>  DNA
<213>  Homo sapiens

<400>  65
cagccacaat gaggaactcc tatagatttc tggcatcctc tctctcagtt gtcgtttctc       60

tcctgctaat tcctgaagat gtctgtgaaa aaattattgg aggaaatgaa gtaactcctc      120

attcaagacc ctacatggtc ctacttagtc ttgacagaaa aaccatctgt gctggggctt      180

tgattgcaaa agactgggtg ttgactgcag ctcactgtaa cttgaacaaa aggtcccagg      240

tcattcttgg ggctcactca ataaccaggg aagagccaac aaaacagata atgcttgtta      300

agaaagagtt tccctatcca tgctatgacc cagccacacg cgaaggtgac cttaaacttt      360

tacagctgac ggaaaaagca aaaattaaca aatatgtgac tatccttcat ctacctaaaa      420

agggggatga tgtgaaacca ggaaccatgt gccaagttgc agggtggggc aggactcaca      480

atagtgcatc ttggtccgat actctgagag aagtcaatat caccatcata gacagaaaag      540

tctgcaatga tcgaaatcac tataatttta accctgtgat tggaatgaat atggtttgtg      600

ctggaagcct ccgaggtgga agagactcgt gcaatggaga ttctggaagc cctttgttgt      660

gcgagggtgt tttccgaggg gtcacttcct ttggccttga aaataaatgc ggagaccctc      720

gtgggcctgg tgtctatatt cttctctcaa agaaacacct caactggata attatgacta      780

tcaagggagc agtttaaata accgtttcct ttcatttact gtggcttctt aatcttttca      840

caaataaaat caatttgcat gactgtaaaa aaaaaaaaaa aaaa                       884


<210>  66
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Arg Asn Ser Tyr Arg Phe Leu Ala Ser Ser Leu Ser Val Val Val 
1               5                   10                  15      


Ser Leu Leu Leu Ile Pro Glu Asp Val Cys Glu Lys Ile Ile Gly Gly 
            20                  25                  30          


Asn Glu Val Thr Pro His Ser Arg Pro Tyr Met Val Leu Leu Ser Leu 
        35                  40                  45              


Asp Arg Lys Thr Ile Cys Ala Gly Ala Leu Ile Ala Lys Asp Trp Val 
    50                  55                  60                  


Leu Thr Ala Ala His Cys Asn Leu Asn Lys Arg Ser Gln Val Ile Leu 
65                  70                  75                  80  


Gly Ala His Ser Ile Thr Arg Glu Glu Pro Thr Lys Gln Ile Met Leu 
                85                  90                  95      


Val Lys Lys Glu Phe Pro Tyr Pro Cys Tyr Asp Pro Ala Thr Arg Glu 
            100                 105                 110         


Gly Asp Leu Lys Leu Leu Gln Leu Met Glu Lys Ala Lys Ile Asn Lys 
        115                 120                 125             


Tyr Val Thr Ile Leu His Leu Pro Lys Lys Gly Asp Asp Val Lys Pro 
    130                 135                 140                 


Gly Thr Met Cys Gln Val Ala Gly Trp Gly Arg Thr His Asn Ser Ala 
145                 150                 155                 160 


Ser Trp Ser Asp Thr Leu Arg Glu Val Asn Ile Thr Ile Ile Asp Arg 
                165                 170                 175     


Lys Val Cys Asn Asp Arg Asn His Tyr Asn Phe Asn Pro Val Ile Gly 
            180                 185                 190         


Met Asn Met Val Cys Ala Gly Ser Leu Arg Gly Gly Arg Asp Ser Cys 
        195                 200                 205             


Asn Gly Asp Ser Gly Ser Pro Leu Leu Cys Glu Gly Val Phe Arg Gly 
    210                 215                 220                 


Val Thr Ser Phe Gly Leu Glu Asn Lys Cys Gly Asp Pro Arg Gly Pro 
225                 230                 235                 240 


Gly Val Tyr Ile Leu Leu Ser Lys Lys His Leu Asn Trp Ile Ile Met 
                245                 250                 255     


Thr Ile Lys Gly Ala Val 
            260         


<210>  67
<211>  1329
<212>  DNA
<213>  Homo sapiens

<400>  67
attctgagcc gagcccggtg ccaagcgcag ctagctcagc aggcggcagc ggcggcctga       60

gcttcagggc agccagctcc ctcccggtct cgccttccct cgcggtcagc atgaaagcct      120

tcagtcccgt gaggtccgtt aggaaaaaca gcctgtcgga ccacagcctg ggcatctccc      180

ggagcaaaac ccctgtggac gacccgatga gcctgctata caacatgaac gactgctact      240

ccaagctcaa ggagctggtg cccagcatcc cccagaacaa gaaggtgagc aagatggaaa      300

tcctgcagca cgtcatcgac tacatcttgg acctgcagat cgccctggac tcgcatccca      360

ctattgtcag cctgcatcac cagagacccg ggcagaacca ggcgtccagg acgccgctga      420

ccaccctcaa cacggatatc agcatcctgt ccttgcaggc ttctgaattc ccttctgagt      480

taatgtcaaa tgacagcaaa gcactgtgtg gctgaataag cggtgttcat gatttctttt      540

attctttgca caacaacaac aacaacaaat tcacggaatc ttttaagtgc tgaacttatt      600

tttcaaccat ttcacaagga ggacaagttg aatggacctt tttaaaaaga aaaaaaaaat      660

gtaaggaaaa ctaagaatga tcatcttccc agggtgttct cttacttgga ctgtgatatt      720

cgttatttat gaaaaagact tttaaatgcc ctttctgcag ttggaaggtt ttctttatat      780

actattccca ccatggggag cgaaaacgtt aaaatcacaa ggaattgccc aatctaagca      840

gactttgcct tttttcaaag gtggagcgtg aataccagaa ggatccagta ttcagtcact      900

taaatgaagt cttttggtca gaaattacct ttttgacaca agcctactga atgctgtgta      960

tatatttata tataaatata tctatttgag tgaaaccttg tgaactcttt aattagagtt     1020

ttcttgtata gtggcagaga tgtctatttc tgcattcaaa agtgtaatgg tgtacttatt     1080

catgctaaac tttttataaa agtttagttg taaacttaac ccttttatac aaaataaatc     1140

aagtgtgttt attgaatggt gattgcctgc tttatttcag aggaccagtg ctttgatttt     1200

tattatgcta tgttataact gaacccaaat aaatacaagt tcaaatttat gtagactgta     1260

taagattata ataaaacatg tctgaagtca aaaaaaaaaa aaaaaaaaaa aaagaaaaaa     1320

aaaaaaaaa                                                             1329


<210>  68
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Lys Ala Phe Ser Pro Val Arg Ser Val Arg Lys Asn Ser Leu Ser 
1               5                   10                  15      


Asp His Ser Leu Gly Ile Ser Arg Ser Lys Thr Pro Val Asp Asp Pro 
            20                  25                  30          


Met Ser Leu Leu Tyr Asn Met Asn Asp Cys Tyr Ser Lys Leu Lys Glu 
        35                  40                  45              


Leu Val Pro Ser Ile Pro Gln Asn Lys Lys Val Ser Lys Met Glu Ile 
    50                  55                  60                  


Leu Gln His Val Ile Asp Tyr Ile Leu Asp Leu Gln Ile Ala Leu Asp 
65                  70                  75                  80  


Ser His Pro Thr Ile Val Ser Leu His His Gln Arg Pro Gly Gln Asn 
                85                  90                  95      


Gln Ala Ser Arg Thr Pro Leu Thr Thr Leu Asn Thr Asp Ile Ser Ile 
            100                 105                 110         


Leu Ser Leu Gln Ala Ser Glu Phe Pro Ser Glu Leu Met Ser Asn Asp 
        115                 120                 125             


Ser Lys Ala Leu Cys Gly 
    130                 


<210>  69
<211>  1159
<212>  DNA
<213>  Homo sapiens

<400>  69
atatactcgt ctctggtaaa gtctgagcag gacagggtgg ctgactggca gatccagagg       60

ttcccttggc agtccacgcc aggccttcac catggatcag ttccctgaat cagtgacaga      120

aaactttgag tacgatgatt tggctgaggc ctgttatatt ggggacatcg tggtctttgg      180

gactgtgttc ctgtccatat tctactccgt catctttgcc attggcctgg tgggaaattt      240

gttggtagtg tttgccctca ccaacagcaa gaagcccaag agtgtcaccg acatttacct      300

cctgaacctg gccttgtctg atctgctgtt tgtagccact ttgcccttct ggactcacta      360

tttgataaat gaaaagggcc tccacaatgc catgtgcaaa ttcactaccg ccttcttctt      420

catcggcttt tttggaagca tattcttcat caccgtcatc agcattgata ggtacctggc      480

catcgtcctg gccgccaact ccatgaacaa ccggaccgtg cagcatggcg tcaccatcag      540

cctaggcgtc tgggcagcag ccattttggt ggcagcaccc cagttcatgt tcacaaagca      600

gaaagaaaat gaatgccttg gtgactaccc cgaggtcctc caggaaatct ggcccgtgct      660

ccgcaatgtg gaaacaaatt ttcttggctt cctactcccc ctgctcatta tgagttattg      720

ctacttcaga atcatccaga cgctgttttc ctgcaagaac cacaagaaag ccaaagccat      780

taaactgatc cttctggtgg tcatcgtgtt tttcctcttc tggacaccct acaacattat      840

gattttcctg gagacgctta agctctatga cttctttccc agttgtgaca tgaggaagga      900

tctgaggctg gccctcagtg tgactgagat ggttgcattt agccattgtt gcctgaatcc      960

tctcatctat gcatttgctg gggagaagtt cagaagatac ctttaccacc tgtatgggaa     1020

atgcctggct gtcctgtgtg ggcgctcagt ccacgttgat ttctcctcat ctgaatcaca     1080

aaggagcagg catggaagtg ttctgagcag caattttact taccacacga gtgatggaga     1140

tgcattgctc cttctctga                                                  1159


<210>  70
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  71
<211>  1638
<212>  DNA
<213>  Homo sapiens

<400>  71
gccgcgcgct ctctcccggc gcccacacct gtctgagcgg cgcagcgagc cgcggcccgg       60

gcgggctgct cggcgcggaa cagtgctcgg catggcaggg attccagggc tcctcttcct      120

tctcttcttt ctgctctgtg ctgttgggca agtgagccct tacagtgccc cctggaaacc      180

cacttggcct gcataccgcc tccctgtcgt cttgccccag tctaccctca atttagccaa      240

gccagacttt ggagccgaag ccaaattaga agtatcttct tcatgtggac cccagtgtca      300

taagggaact ccactgccca cttacgaaga ggccaagcaa tatctgtctt atgaaacgct      360

ctatgccaat ggcagccgca cagagacgca ggtgggcatc tacatcctca gcagtagtgg      420

agatggggcc caacaccgag actcagggtc ttcaggaaag tctcgaagga agcggcagat      480

ttatggctat gacagcaggt tcagcatttt tgggaaggac ttcctgctca actacccttt      540

ctcaacatca gtgaagttat ccacgggctg caccggcacc ctggtggcag agaagcatgt      600

cctcacagct gcccactgca tacacgatgg aaaaacctat gtgaaaggaa cccagaagct      660

tcgagtgggc ttcctaaagc ccaagtttaa agatggtggt cgaggggcca acgactccac      720

ttcagccatg cccgagcaga tgaaatttca gtggatccgg gtgaaacgca cccatgtgcc      780

caagggttgg atcaagggca atgccaatga catcggcatg gattatgatt atgccctcct      840

ggaactcaaa aagccccaca agagaaaatt tatgaagatt ggggtgagcc ctcctgctaa      900

gcagctgcca gggggcagaa ttcacttctc tggttatgac aatgaccgac caggcaattt      960

ggtgtatcgc ttctgtgacg tcaaagacga gacctatgac ttgctctacc agcaatgcga     1020

tgcccagcca ggggccagcg ggtctggggt ctatgtgagg atgtggaaga gacagcagca     1080

gaagtgggag cgaaaaatta ttggcatttt ttcagggcac cagtgggtgg acatgaatgg     1140

ttccccacag gatttcaacg tggctgtcag aatcactcct ctcaaatatg cccagatttg     1200

ctattggatt aaaggaaact acctggattg tagggagggg tgacacagtg ttccctcctg     1260

gcagcaatta agggtcttca tgttcttatt ttaggagagg ccaaattgtt ttttgtcatt     1320

ggcgtgcaca cgtgtgtgtg tgtgtgtgtg tgtgtgtaag gtgtcttata atcttttacc     1380

tatttcttac aattgcaaga tgactggctt tactatttga aaactggttt gtgtatcata     1440

tcatatatca tttaagcagt ttgaaggcat acttttgcat agaaataaaa aaaatactga     1500

tttggggcaa tgaggaatat ttgacaatta agttaatctt cacgtttttg caaactttga     1560

tttttatttc atctgaactt gtttcaaaga tttatattaa atatttggca tacaagagat     1620

atgaaaaaaa aaaaaaaa                                                   1638


<210>  72
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Gly Ile Pro Gly Leu Leu Phe Leu Leu Phe Phe Leu Leu Cys 
1               5                   10                  15      


Ala Val Gly Gln Val Ser Pro Tyr Ser Ala Pro Trp Lys Pro Thr Trp 
            20                  25                  30          


Pro Ala Tyr Arg Leu Pro Val Val Leu Pro Gln Ser Thr Leu Asn Leu 
        35                  40                  45              


Ala Lys Pro Asp Phe Gly Ala Glu Ala Lys Leu Glu Val Ser Ser Ser 
    50                  55                  60                  


Cys Gly Pro Gln Cys His Lys Gly Thr Pro Leu Pro Thr Tyr Glu Glu 
65                  70                  75                  80  


Ala Lys Gln Tyr Leu Ser Tyr Glu Thr Leu Tyr Ala Asn Gly Ser Arg 
                85                  90                  95      


Thr Glu Thr Gln Val Gly Ile Tyr Ile Leu Ser Ser Ser Gly Asp Gly 
            100                 105                 110         


Ala Gln His Arg Asp Ser Gly Ser Ser Gly Lys Ser Arg Arg Lys Arg 
        115                 120                 125             


Gln Ile Tyr Gly Tyr Asp Ser Arg Phe Ser Ile Phe Gly Lys Asp Phe 
    130                 135                 140                 


Leu Leu Asn Tyr Pro Phe Ser Thr Ser Val Lys Leu Ser Thr Gly Cys 
145                 150                 155                 160 


Thr Gly Thr Leu Val Ala Glu Lys His Val Leu Thr Ala Ala His Cys 
                165                 170                 175     


Ile His Asp Gly Lys Thr Tyr Val Lys Gly Thr Gln Lys Leu Arg Val 
            180                 185                 190         


Gly Phe Leu Lys Pro Lys Phe Lys Asp Gly Gly Arg Gly Ala Asn Asp 
        195                 200                 205             


Ser Thr Ser Ala Met Pro Glu Gln Met Lys Phe Gln Trp Ile Arg Val 
    210                 215                 220                 


Lys Arg Thr His Val Pro Lys Gly Trp Ile Lys Gly Asn Ala Asn Asp 
225                 230                 235                 240 


Ile Gly Met Asp Tyr Asp Tyr Ala Leu Leu Glu Leu Lys Lys Pro His 
                245                 250                 255     


Lys Arg Lys Phe Met Lys Ile Gly Val Ser Pro Pro Ala Lys Gln Leu 
            260                 265                 270         


Pro Gly Gly Arg Ile His Phe Ser Gly Tyr Asp Asn Asp Arg Pro Gly 
        275                 280                 285             


Asn Leu Val Tyr Arg Phe Cys Asp Val Lys Asp Glu Thr Tyr Asp Leu 
    290                 295                 300                 


Leu Tyr Gln Gln Cys Asp Ala Gln Pro Gly Ala Ser Gly Ser Gly Val 
305                 310                 315                 320 


Tyr Val Arg Met Trp Lys Arg Gln Gln Gln Lys Trp Glu Arg Lys Ile 
                325                 330                 335     


Ile Gly Ile Phe Ser Gly His Gln Trp Val Asp Met Asn Gly Ser Pro 
            340                 345                 350         


Gln Asp Phe Asn Val Ala Val Arg Ile Thr Pro Leu Lys Tyr Ala Gln 
        355                 360                 365             


Ile Cys Tyr Trp Ile Lys Gly Asn Tyr Leu Asp Cys Arg Glu Gly 
    370                 375                 380             


<210>  73
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  73
atggctacct gggccctcct gctccttgca gccatgctcc tgggcaaccc aggtctggtc       60

ttctctcgtc tgagccctga gtactacgac ctggcaagag cccacctgcg tgatgaggag      120

aaatcctgcc cgtgcctggc ccaggagggc ccccagggtg acctgttgac caaaacacag      180

gagctgggcc gtgactacag gacctgtctg acgatagtcc aaaaactgaa gaagatggtg      240

gataagccca cccagagaag tgtttccaat gctgcgaccc gggtgtgtag gacggggagg      300

tcacgatggc gcgacgtctg cagaaatttc atgaggaggt atcagtctag agttacccag      360

ggcctcgtgg ccggagaaac tgcccagcag atctgtgagg acctcaggtt gtgtatacct      420

tctacaggtc ccctctga                                                    438


<210>  74
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Thr Trp Ala Leu Leu Leu Leu Ala Ala Met Leu Leu Gly Asn 
1               5                   10                  15      


Pro Gly Leu Val Phe Ser Arg Leu Ser Pro Glu Tyr Tyr Asp Leu Ala 
            20                  25                  30          


Arg Ala His Leu Arg Asp Glu Glu Lys Ser Cys Pro Cys Leu Ala Gln 
        35                  40                  45              


Glu Gly Pro Gln Gly Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly Arg 
    50                  55                  60                  


Asp Tyr Arg Thr Cys Leu Thr Ile Val Gln Lys Leu Lys Lys Met Val 
65                  70                  75                  80  


Asp Lys Pro Thr Gln Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys 
                85                  90                  95      


Arg Thr Gly Arg Ser Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg 
            100                 105                 110         


Arg Tyr Gln Ser Arg Val Thr Gln Gly Leu Val Ala Gly Glu Thr Ala 
        115                 120                 125             


Gln Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Pro 
    130                 135                 140                 


Leu 
145 


<210>  75
<211>  1742
<212>  DNA
<213>  Homo sapiens

<400>  75
aaccattcca ggagcctcgg tgaagagagg atatccatct gtgtagccgc ttctctatac       60

gggatcccag ctccatggca gcccgtctgc tcctcctggg catccttctc ctgctgctgc      120

ccctgcccgt ccctgccccg tgccacacag ccgcacgctc agagtgcaag cgcagccaca      180

agttcgtgcc tggtgcatgg ctggccgggg agggtgtgga cgtgaccagc ctccgccgct      240

cgggctcctt cccagtggac acacaaaggt tcctgcggcc cgacggcacc tgcaccctct      300

gtgaaaatgc cctacaggag ggcaccctcc agcgcctgcc tctggcgctc accaactggc      360

gggcccaggg ctctggctgc cagcgccatg taaccagggc caaagtcagc tccactgaag      420

ctgtggcccg ggatgcggct cgtagcatcc gcaacgactg gaaggtcggg ctggacgtga      480

ctcctaagcc caccagcaat gtgcatgtgt ctgtggccgg ctcacactca caggcagcca      540

actttgcagc ccagaagacc caccaggacc agtacagctt cagcactgac acggtggagt      600

gccgcttcta cagtttccat gtggtacaca ctcccccgct gcaccctgac ttcaagaggg      660

ccctcgggga cctgccccac cacttcaacg cctccaccca gcccgcctac ctcaggctta      720

tctccaacta cggcacccac ttcatccggg ctgtggagct gggtggccgc atatcggccc      780

tcactgccct gcgcacctgc gagctggccc tggaagggct cacggacaac gaggtggagg      840

actgcctgac tgtcgaggcc caggtcaaca taggcatcca cggcagcatc tctgctgaag      900

ccaaggcctg tgaggagaag aagaagaagc acaagatgac ggcctccttc caccaaacct      960

accgggagcg ccattcggaa gtggttggcg gccatcacac ctccattaac gacctgctgt     1020

tcgggatcca ggccgggccc gagcagtact cagcctgggt aaactcgctg cccggcagcc     1080

ctggcctggt ggactacacc ctggaacccc tgcacgtgct gctggacagc caggacccgc     1140

ggcgggaggc actgaggagg gccctgagtc agtacctgac ggacagggct cgctggaggg     1200

actgcagccg gccgtgccca ccagggcggc agaagagccc ccgagaccca tgccagtgtg     1260

tgtgccatgg ctcagcggtc accacccagg actgctgccc tcggcagagg ggcctggccc     1320

agctggaggt gaccttcatc caagcatggg gcctgtgggg ggactggttc actgccacgg     1380

atgcctatgt gaagctcttc tttggtggcc aggagctgag gacgagcacc gtgtgggaca     1440

ataacaaccc catctggtca gtgcggctgg attttgggga tgtgctcctg gccacagggg     1500

ggcccctgag gttgcaggtc tgggatcagg actctggcag ggacgatgac ctccttggca     1560

cctgtgatca ggctcccaag tctggttccc atgaggtgag atgcaacctg aatcatggcc     1620

acctaaaatt ccgctatcat gccaggtgct tgccccacct gggaggaggc acctgcctgg     1680

actatgtccc ccaaatgctt ctgggggagc ctccaggaaa ccggagtggg gccgtgtggt     1740

ga                                                                    1742


<210>  76
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Ala Arg Leu Leu Leu Leu Gly Ile Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Leu Pro Val Pro Ala Pro Cys His Thr Ala Ala Arg Ser Glu Cys Lys 
            20                  25                  30          


Arg Ser His Lys Phe Val Pro Gly Ala Trp Leu Ala Gly Glu Gly Val 
        35                  40                  45              


Asp Val Thr Ser Leu Arg Arg Ser Gly Ser Phe Pro Val Asp Thr Gln 
    50                  55                  60                  


Arg Phe Leu Arg Pro Asp Gly Thr Cys Thr Leu Cys Glu Asn Ala Leu 
65                  70                  75                  80  


Gln Glu Gly Thr Leu Gln Arg Leu Pro Leu Ala Leu Thr Asn Trp Arg 
                85                  90                  95      


Ala Gln Gly Ser Gly Cys Gln Arg His Val Thr Arg Ala Lys Val Ser 
            100                 105                 110         


Ser Thr Glu Ala Val Ala Arg Asp Ala Ala Arg Ser Ile Arg Asn Asp 
        115                 120                 125             


Trp Lys Val Gly Leu Asp Val Thr Pro Lys Pro Thr Ser Asn Val His 
    130                 135                 140                 


Val Ser Val Ala Gly Ser His Ser Gln Ala Ala Asn Phe Ala Ala Gln 
145                 150                 155                 160 


Lys Thr His Gln Asp Gln Tyr Ser Phe Ser Thr Asp Thr Val Glu Cys 
                165                 170                 175     


Arg Phe Tyr Ser Phe His Val Val His Thr Pro Pro Leu His Pro Asp 
            180                 185                 190         


Phe Lys Arg Ala Leu Gly Asp Leu Pro His His Phe Asn Ala Ser Thr 
        195                 200                 205             


Gln Pro Ala Tyr Leu Arg Leu Ile Ser Asn Tyr Gly Thr His Phe Ile 
    210                 215                 220                 


Arg Ala Val Glu Leu Gly Gly Arg Ile Ser Ala Leu Thr Ala Leu Arg 
225                 230                 235                 240 


Thr Cys Glu Leu Ala Leu Glu Gly Leu Thr Asp Asn Glu Val Glu Asp 
                245                 250                 255     


Cys Leu Thr Val Glu Ala Gln Val Asn Ile Gly Ile His Gly Ser Ile 
            260                 265                 270         


Ser Ala Glu Ala Lys Ala Cys Glu Glu Lys Lys Lys Lys His Lys Met 
        275                 280                 285             


Thr Ala Ser Phe His Gln Thr Tyr Arg Glu Arg His Ser Glu Val Val 
    290                 295                 300                 


Gly Gly His His Thr Ser Ile Asn Asp Leu Leu Phe Gly Ile Gln Ala 
305                 310                 315                 320 


Gly Pro Glu Gln Tyr Ser Ala Trp Val Asn Ser Leu Pro Gly Ser Pro 
                325                 330                 335     


Gly Leu Val Asp Tyr Thr Leu Glu Pro Leu His Val Leu Leu Asp Ser 
            340                 345                 350         


Gln Asp Pro Arg Arg Glu Ala Leu Arg Arg Ala Leu Ser Gln Tyr Leu 
        355                 360                 365             


Thr Asp Arg Ala Arg Trp Arg Asp Cys Ser Arg Pro Cys Pro Pro Gly 
    370                 375                 380                 


Arg Gln Lys Ser Pro Arg Asp Pro Cys Gln Cys Val Cys His Gly Ser 
385                 390                 395                 400 


Ala Val Thr Thr Gln Asp Cys Cys Pro Arg Gln Arg Gly Leu Ala Gln 
                405                 410                 415     


Leu Glu Val Thr Phe Ile Gln Ala Trp Gly Leu Trp Gly Asp Trp Phe 
            420                 425                 430         


Thr Ala Thr Asp Ala Tyr Val Lys Leu Phe Phe Gly Gly Gln Glu Leu 
        435                 440                 445             


Arg Thr Ser Thr Val Trp Asp Asn Asn Asn Pro Ile Trp Ser Val Arg 
    450                 455                 460                 


Leu Asp Phe Gly Asp Val Leu Leu Ala Thr Gly Gly Pro Leu Arg Leu 
465                 470                 475                 480 


Gln Val Trp Asp Gln Asp Ser Gly Arg Asp Asp Asp Leu Leu Gly Thr 
                485                 490                 495     


Cys Asp Gln Ala Pro Lys Ser Gly Ser His Glu Val Arg Cys Asn Leu 
            500                 505                 510         


Asn His Gly His Leu Lys Phe Arg Tyr His Ala Arg Cys Leu Pro His 
        515                 520                 525             


Leu Gly Gly Gly Thr Cys Leu Asp Tyr Val Pro Gln Met Leu Leu Gly 
    530                 535                 540                 


Glu Pro Pro Gly Asn Arg Ser Gly Ala Val Trp 
545                 550                 555 


<210>  77
<211>  1967
<212>  DNA
<213>  Homo sapiens

<400>  77
gaaaggacag caacagtcag gtggtttacc ttccagaggc tggcaatgct gtttcactgg       60

aggacacggc taagaaggaa gtccaccagc ctgccaagat gaattgcctt gaagggccag      120

gtaagacctg tggccccttg gcttctgagg aggagctggt gtctgcctgc cagttggaaa      180

aagaagaaga gaatgaaggg gaggaggagg aagaggagga ggacgaggag gatctggacc      240

cagatctgga cccagaccta gaggaggaag agaatgatct tggggatcca gctgtacttg      300

gtgctgtcca caacacccag agagctctgc ttagctcccc tggagtcaag gcccctggta      360

tgctgggaat gtcacttgcc tccttgcatt ttctgtggca gaccttggac tacctgtcgc      420

ccatcccttt ctggcctaca tttcccagca ccagctctcc agcacagcac tttggacctc      480

ggctgccctc accagaccca actctcttct gcagcctgct gacctcgtgg ccccctaggt      540

tcagtcatct gacccagctc caccctcggc accaacgaat cttgcagcag cagcagcata      600

gtcaaacacc aagtccccca gccaagaagc cttggtctca gcagccagac ccctatgcta      660

acctcatgac cagaaaagag aaggactggg tgataaaagt gcagatggtg cagctgcaga      720

gtgcaaaacc ccgcctggat gactactatt accaggaata ttaccagaag ctagagaaga      780

agcaggcaga cgaagagcta cttggacgaa gaaaccgggt tgagtccctc aagctggtaa      840

cgccttacat tccgaaggca gaggcttatg agtccgtggt ccgaatcgag ggttccctgg      900

gccaggtagc tgtgtcgaca tgcttcagcc ctcgccgagc tattgatgcg gtaccccatg      960

gaactcaaga gcaggatata gaagctgcaa gcagtcagag gcttcgggta ttataccgga     1020

ttgagaagat gttccttcag ttactagaaa tagaggaagg ctggaagtat aggcctccac     1080

cgccctgctt ttctgagcag caaagcaacc aggttgagaa gctcttccag accttaaaga     1140

cccaggagca gaacaacctg gaagaggcag cagatggctt cctgcaggtg ctctctgtga     1200

ggaaggggaa ggccctggtg gcccggctgc tccccttcct gccccaggat caggctgtta     1260

ccattctttt ggctatcacc caccatctgc ccctcctggt ccggagggat gtggctgatc     1320

aggccctaca aatgttattc aaacctctgg gcaaatgtat tagtcacttg accctccacg     1380

aactcctcca aggacttcag ggattaacgc tgttgccacc tggctcctca gagcggccag     1440

tcaccgtggt gcttcagaat cagtttggaa tatctttgct ctatgccctg ctgagccatg     1500

gggagcaact ggtatcgctg cattcttccc tagaggaacc caacagtgac catacagctt     1560

ggacagacat ggtggttctg attgcctggg agatagccca aatgcctaca gcctctctgg     1620

cagaacccct agctttcccc agcaacctac ttcccctgtt ctgtcaccac gtggacaaac     1680

aattggttca gcagctggag gccaggatgg agtttgcctg gatttactga tctgtttgtt     1740

ctggaatacg tgtatgtggg aagttgaatc atcagacact agctacatag actatgttta     1800

cagggatcca gagagtctga agacatttct tatgccttta tatattggag aacccttccc     1860

cattttcata tcctttcttc aaaaatctaa atgatgtgcc taaaaataag acatggcata     1920

ataaggtata attaaagaga taatagaatg aaaaaaaaaa aaaaaaa                   1967


<210>  78
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Asn Cys Leu Glu Gly Pro Gly Lys Thr Cys Gly Pro Leu Ala Ser 
1               5                   10                  15      


Glu Glu Glu Leu Val Ser Ala Cys Gln Leu Glu Lys Glu Glu Glu Asn 
            20                  25                  30          


Glu Gly Glu Glu Glu Glu Glu Glu Glu Asp Glu Glu Asp Leu Asp Pro 
        35                  40                  45              


Asp Leu Asp Pro Asp Leu Glu Glu Glu Glu Asn Asp Leu Gly Asp Pro 
    50                  55                  60                  


Ala Val Leu Gly Ala Val His Asn Thr Gln Arg Ala Leu Leu Ser Ser 
65                  70                  75                  80  


Pro Gly Val Lys Ala Pro Gly Met Leu Gly Met Ser Leu Ala Ser Leu 
                85                  90                  95      


His Phe Leu Trp Gln Thr Leu Asp Tyr Leu Ser Pro Ile Pro Phe Trp 
            100                 105                 110         


Pro Thr Phe Pro Ser Thr Ser Ser Pro Ala Gln His Phe Gly Pro Arg 
        115                 120                 125             


Leu Pro Ser Pro Asp Pro Thr Leu Phe Cys Ser Leu Leu Thr Ser Trp 
    130                 135                 140                 


Pro Pro Arg Phe Ser His Leu Thr Gln Leu His Pro Arg His Gln Arg 
145                 150                 155                 160 


Ile Leu Gln Gln Gln Gln His Ser Gln Thr Pro Ser Pro Pro Ala Lys 
                165                 170                 175     


Lys Pro Trp Ser Gln Gln Pro Asp Pro Tyr Ala Asn Leu Met Thr Arg 
            180                 185                 190         


Lys Glu Lys Asp Trp Val Ile Lys Val Gln Met Val Gln Leu Gln Ser 
        195                 200                 205             


Ala Lys Pro Arg Leu Asp Asp Tyr Tyr Tyr Gln Glu Tyr Tyr Gln Lys 
    210                 215                 220                 


Leu Glu Lys Lys Gln Ala Asp Glu Glu Leu Leu Gly Arg Arg Asn Arg 
225                 230                 235                 240 


Val Glu Ser Leu Lys Leu Val Thr Pro Tyr Ile Pro Lys Ala Glu Ala 
                245                 250                 255     


Tyr Glu Ser Val Val Arg Ile Glu Gly Ser Leu Gly Gln Val Ala Val 
            260                 265                 270         


Ser Thr Cys Phe Ser Pro Arg Arg Ala Ile Asp Ala Val Pro His Gly 
        275                 280                 285             


Thr Gln Glu Gln Asp Ile Glu Ala Ala Ser Ser Gln Arg Leu Arg Val 
    290                 295                 300                 


Leu Tyr Arg Ile Glu Lys Met Phe Leu Gln Leu Leu Glu Ile Glu Glu 
305                 310                 315                 320 


Gly Trp Lys Tyr Arg Pro Pro Pro Pro Cys Phe Ser Glu Gln Gln Ser 
                325                 330                 335     


Asn Gln Val Glu Lys Leu Phe Gln Thr Leu Lys Thr Gln Glu Gln Asn 
            340                 345                 350         


Asn Leu Glu Glu Ala Ala Asp Gly Phe Leu Gln Val Leu Ser Val Arg 
        355                 360                 365             


Lys Gly Lys Ala Leu Val Ala Arg Leu Leu Pro Phe Leu Pro Gln Asp 
    370                 375                 380                 


Gln Ala Val Thr Ile Leu Leu Ala Ile Thr His His Leu Pro Leu Leu 
385                 390                 395                 400 


Val Arg Arg Asp Val Ala Asp Gln Ala Leu Gln Met Leu Phe Lys Pro 
                405                 410                 415     


Leu Gly Lys Cys Ile Ser His Leu Thr Leu His Glu Leu Leu Gln Gly 
            420                 425                 430         


Leu Gln Gly Leu Thr Leu Leu Pro Pro Gly Ser Ser Glu Arg Pro Val 
        435                 440                 445             


Thr Val Val Leu Gln Asn Gln Phe Gly Ile Ser Leu Leu Tyr Ala Leu 
    450                 455                 460                 


Leu Ser His Gly Glu Gln Leu Val Ser Leu His Ser Ser Leu Glu Glu 
465                 470                 475                 480 


Pro Asn Ser Asp His Thr Ala Trp Thr Asp Met Val Val Leu Ile Ala 
                485                 490                 495     


Trp Glu Ile Ala Gln Met Pro Thr Ala Ser Leu Ala Glu Pro Leu Ala 
            500                 505                 510         


Phe Pro Ser Asn Leu Leu Pro Leu Phe Cys His His Val Asp Lys Gln 
        515                 520                 525             


Leu Val Gln Gln Leu Glu Ala Arg Met Glu Phe Ala Trp Ile Tyr 
    530                 535                 540             


<210>  79
<211>  3813
<212>  DNA
<213>  Homo sapiens

<400>  79
agacaggcgg agcctcacct ggggctgccc gccagcccag acaagctcag actgggtgcc       60

tgtggccctg ggaggaggtg gaaggggagg agcaggccac acaggcacag gccggtgagg      120

gacctgccca gacctggagg gtctcgctct gtcacacagg ctggagtgca gtggtgtgat      180

cttggctcat cgtaacctcc acctcccggg ttcaagtgat tctcatgcct cagcctcccg      240

agtagctggg attacaggtg gtgacttcca agagtgactc cgtcggagga aaatgactcc      300

ccagtcgctg ctgcagacga cactgttcct gctgagtctg ctcttcctgg tccaaggtgc      360

ccacggcagg ggccacaggg aagactttcg cttctgcagc cagcggaacc agacacacag      420

gagcagcctc cactacaaac ccacaccaga cctgcgcatc tccatcgaga actccgaaga      480

ggccctcaca gtccatgccc ctttccctgc agcccaccct gcttcccgat ccttccctga      540

ccccaggggc ctctaccact tctgcctcta ctggaaccga catgctggga gattacatct      600

tctctatggc aagcgtgact tcttgctgag tgacaaagcc tctagcctcc tctgcttcca      660

gcaccaggag gagagcctgg ctcagggccc cccgctgtta gccacttctg tcacctcctg      720

gtggagccct cagaacatca gcctgcccag tgccgccagc ttcaccttct ccttccacag      780

tcctccccac acggccgctc acaatgcctc ggtggacatg tgcgagctca aaagggacct      840

ccagctgctc agccagttcc tgaagcatcc ccagaaggcc tcaaggaggc cctcggctgc      900

ccccgccagc cagcagttgc agagcctgga gtcgaaactg acctctgtga gattcatggg      960

ggacatggtg tccttcgagg aggaccggat caacgccacg gtgtggaagc tccagcccac     1020

agccggcctc caggacctgc acatccactc ccggcaggag gaggagcaga gcgagatcat     1080

ggagtactcg gtgctgctgc ctcgaacact cttccagagg acgaaaggcc ggagcgggga     1140

ggctgagaag agactcctcc tggtggactt cagcagccaa gccctgttcc aggacaagaa     1200

ttccagccaa gtcctgggtg agaaggtctt ggggattgtg gtacagaaca ccaaagtagc     1260

caacctcacg gagcccgtgg tgctcacttt ccagcaccag ctacagccga agaatgtgac     1320

tctgcaatgt gtgttctggg ttgaagaccc cacattgagc agcccggggc attggagcag     1380

tgctgggtgt gagaccgtca ggagagaaac ccaaacatcc tgcttctgca accacttgac     1440

ctactttgca gtgctgatgg tctcctcggt ggaggtggac gccgtgcaca agcactacct     1500

gagcctcctc tcctacgtgg gctgtgtcgt ctctgccctg gcctgccttg tcaccattgc     1560

cgcctacctc tgctccagga ggaaacctcg ggactacacc atcaaggtgc acatgaacct     1620

gctgctggcc gtcttcctgc tggacacgag cttcctgctc agcgagccgg tggccctgac     1680

aggctctgag gctggctgcc gagccagtgc catcttcctg cacttctccc tgctcacctg     1740

cctttcctgg atgggcctcg aggggtacaa cctctaccga ctcgtggtgg aggtctttgg     1800

cacctatgtc cctggctacc tactcaagct gagcgccatg ggctggggct tccccatctt     1860

tctggtgacg ctggtggccc tggtggatgt ggacaactat ggccccatca tcttggctgt     1920

gcataggact ccagagggcg tcatctaccc ttccatgtgc tggatccggg actccctggt     1980

cagctacatc accaacctgg gcctcttcag cctggtgttt ctgttcaaca tggccatgct     2040

agccaccatg gtggtgcaga tcctgcggct gcgcccccac acccaaaagt ggtcacatgt     2100

gctgacactg ctgggcctca gcctggtcct tggcctgccc tgggccttga tcttcttctc     2160

ctttgcttct ggcaccttcc agcttgtcgt cctctacctt ttcagcatca tcacctcctt     2220

ccaaggcttc ctcatcttca tctggtactg gtccatgcgg ctgcaggccc ggggtggccc     2280

ctcccctctg aagagcaact cagacagcgc caggctcccc atcagctcgg gcagcacctc     2340

gtccagccgc atctaggcct ccagcccacc tgcccatgtg atgaagcaga gattcggcct     2400

cgtcgcacac tgcctgtggc ccccgagccc ggcccagccc caggccagtc agccgcagac     2460

tttggaaagc ccaacgacca tggagagatg ggccgttgcc atggtggacg gactcccggg     2520

ctgggctttt gaattggcct tggggactac tcggctctca ctcagctccc acgggactca     2580

gaagtgcgcc gccatgctgc ctagggtact gtccccacat ctgtcccaac ccagctggag     2640

gcctggtctc tccttacaac ccctgggccc agccctcatt gctgggggcc aggccttgga     2700

tcttgagggt ctggcacatc cttaatcctg tgcccctgcc tgggacagaa atgtggctcc     2760

agttgctctg tctctcgtgg tcaccctgag ggcactctgc atcctctgtc attttaacct     2820

caggtggcac ccagggcgaa tggggcccag ggcagacctt cagggccaga gccctggcgg     2880

aggagaggcc ctttgccagg agcacagcag cagctcgcct acctctgagc ccaggccccc     2940

tccctccctc agccccccag tcctccctcc atcttccctg gggttctcct cctctcccag     3000

ggcctccttg ctccttcgtt cacagctggg ggtccccgat tccaatgctg ttttttgggg     3060

agtggtttcc aggagctgcc tggtgtctgc tgtaaatgtt tgtctactgc acaagcctcg     3120

gcctgcccct gagccaggct cggtaccgat gcgtgggctg ggctaggtcc ctctgtccat     3180

ctgggccttt gtatgagctg cattgccctt gctcaccctg accaagcaca cgcctcagag     3240

gggccctcag cctctcctga agccctcttg tggcaagaac tgtggaccat gccagtcccg     3300

tctggtttcc atcccaccac tccaaggact gagactgacc tcctctggtg acactggcct     3360

agggcctgac actctcctaa gaggttctct ccaagccccc aaatagctcc aggcgccctc     3420

ggccgcccat catggttaat tctgtccaac aaacacacac gggtagattg ctggcctgtt     3480

gtaggtggta gggacacaga tgaccgacct ggtcactcct cctgccaaca ttcagtctgg     3540

tatgtgaggc gtgcgtgaag caagaactcc tggagctaca gggacaggga gccatcattc     3600

ctgcctggga atcctggaag acttcctgca ggagtcagcg ttcaatcttg accttgaaga     3660

tgggaaggat gttcttttta cgtaccaatt cttttgtctt ttgatattaa aaagaagtac     3720

atgttcattg tagagaattt ggaaactgta gaagagaatc aagaagaaaa ataaaaatca     3780

gctgttgtaa tcacctagca aactggcgta agc                                  3813


<210>  80
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Thr Pro Gln Ser Leu Leu Gln Thr Thr Leu Phe Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Leu Val Gln Gly Ala His Gly Arg Gly His Arg Glu Asp Phe 
            20                  25                  30          


Arg Phe Cys Ser Gln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr 
        35                  40                  45              


Lys Pro Thr Pro Asp Leu Arg Ile Ser Ile Glu Asn Ser Glu Glu Ala 
    50                  55                  60                  


Leu Thr Val His Ala Pro Phe Pro Ala Ala His Pro Ala Ser Arg Ser 
65                  70                  75                  80  


Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg 
                85                  90                  95      


His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu 
            100                 105                 110         


Ser Asp Lys Ala Ser Ser Leu Leu Cys Phe Gln His Gln Glu Glu Ser 
        115                 120                 125             


Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp 
    130                 135                 140                 


Ser Pro Gln Asn Ile Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser 
145                 150                 155                 160 


Phe His Ser Pro Pro His Thr Ala Ala His Asn Ala Ser Val Asp Met 
                165                 170                 175     


Cys Glu Leu Lys Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His 
            180                 185                 190         


Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln 
        195                 200                 205             


Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Val Arg Phe Met Gly Asp 
    210                 215                 220                 


Met Val Ser Phe Glu Glu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 
225                 230                 235                 240 


Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu 
                245                 250                 255     


Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro Arg Thr 
            260                 265                 270         


Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu 
        275                 280                 285             


Leu Leu Val Asp Phe Ser Ser Gln Ala Leu Phe Gln Asp Lys Asn Ser 
    290                 295                 300                 


Ser Gln Val Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr 
305                 310                 315                 320 


Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln 
                325                 330                 335     


Leu Gln Pro Lys Asn Val Thr Leu Gln Cys Val Phe Trp Val Glu Asp 
            340                 345                 350         


Pro Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Thr 
        355                 360                 365             


Val Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His Leu Thr Tyr 
    370                 375                 380                 


Phe Ala Val Leu Met Val Ser Ser Val Glu Val Asp Ala Val His Lys 
385                 390                 395                 400 


His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu 
                405                 410                 415     


Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Val Pro Leu 
            420                 425                 430         


Pro Cys Arg Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val His Met Asn 
        435                 440                 445             


Leu Leu Leu Ala Val Phe Leu Leu Asp Thr Ser Phe Leu Leu Ser Glu 
    450                 455                 460                 


Pro Val Ala Leu Thr Gly Ser Glu Ala Gly Cys Arg Ala Ser Ala Ile 
465                 470                 475                 480 


Phe Leu His Phe Ser Leu Leu Thr Cys Leu Ser Trp Met Gly Leu Glu 
                485                 490                 495     


Gly Tyr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr Tyr Val 
            500                 505                 510         


Pro Gly Tyr Leu Leu Lys Leu Ser Ala Met Gly Trp Gly Phe Pro Ile 
        515                 520                 525             


Phe Leu Val Thr Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly Pro 
    530                 535                 540                 


Ile Ile Leu Ala Val His Arg Thr Pro Glu Gly Val Ile Tyr Pro Ser 
545                 550                 555                 560 


Met Cys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile Thr Asn Leu Gly 
                565                 570                 575     


Leu Phe Ser Leu Val Phe Leu Phe Asn Met Ala Met Leu Ala Thr Met 
            580                 585                 590         


Val Val Gln Ile Leu Arg Leu Arg Pro His Thr Gln Lys Trp Ser His 
        595                 600                 605             


Val Leu Thr Leu Leu Gly Leu Ser Leu Val Leu Gly Leu Pro Trp Ala 
    610                 615                 620                 


Leu Ile Phe Phe Ser Phe Ala Ser Gly Thr Phe Gln Leu Val Val Leu 
625                 630                 635                 640 


Tyr Leu Phe Ser Ile Ile Thr Ser Phe Gln Gly Phe Leu Ile Phe Ile 
                645                 650                 655     


Trp Tyr Trp Ser Met Arg Leu Gln Ala Arg Gly Gly Pro Ser Pro Leu 
            660                 665                 670         


Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr 
        675                 680                 685             


Ser Ser Ser Arg Ile 
    690             


<210>  81
<211>  733
<212>  DNA
<213>  Homo sapiens

<400>  81
aaacagcagg aaatagaaac ttaagagaaa tacacacttc tgagaaactg aaacgacagg       60

ggaaaggagg tctcactgag caccgtccca gcatccggac accacagcgg cccttcgctc      120

cacgcagaaa accacacttc tcaaaccttc actcaacact tccttcccca aagccagaag      180

atgcacaagg aggaacatga ggtggctgtg ctgggggcac cccccagcac catccttcca      240

aggtccaccg tgatcaacat ccacagcgag acctccgtgc ccgaccatgt cgtctggtcc      300

ctgttcaaca ccctcttctt gaactggtgc tgtctgggct tcatagcatt cgcctactcc      360

gtgaagtcta gggacaggaa gatggttggc gacgtgaccg gggcccaggc ctatgcctcc      420

accgccaagt gcctgaacat ctgggccctg attctgggca tcctcatgac cattggattc      480

atcctgttac tggtattcgg ctctgtgaca gtctaccata ttatgttaca gataatacag      540

gaaaaacggg gttactagta gccgcccata gcctgcaacc tttgcactcc actgtgcaat      600

gctggccctg cacgctgggg ctgttgcccc tgcccccttg gtcctgcccc tagatacagc      660

agtttatacc cacacacctg tctacagtgt cattcaataa agtgcacgtg cttgtgaaaa      720

aaaaaaaaaa aaa                                                         733


<210>  82
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Asn His Ile Val Gln Thr Phe Ser Pro Val Asn Ser Gly Gln Pro 
1               5                   10                  15      


Pro Asn Tyr Glu Met Leu Lys Glu Glu Gln Glu Val Ala Met Leu Gly 
            20                  25                  30          


Val Pro His Asn Pro Ala Pro Pro Met Ser Thr Val Ile His Ile Arg 
        35                  40                  45              


Ser Glu Thr Ser Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr 
    50                  55                  60                  


Leu Phe Met Asn Thr Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser 
65                  70                  75                  80  


Val Lys Ser Arg Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln 
                85                  90                  95      


Ala Tyr Ala Ser Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu 
            100                 105                 110         


Gly Ile Phe Met Thr Ile Leu Leu Ile Ile Ile Pro Val Leu Val Val 
        115                 120                 125             


Gln Ala Gln Arg 
    130         


<210>  83
<211>  1967
<212>  DNA
<213>  Homo sapiens

<400>  83
gaaaggacag caacagtcag gtggtttacc ttccagaggc tggcaatgct gtttcactgg       60

aggacacggc taagaaggaa gtccaccagc ctgccaagat gaattgcctt gaagggccag      120

gtaagacctg tggccccttg gcttctgagg aggagctggt gtctgcctgc cagttggaaa      180

aagaagaaga gaatgaaggg gaggaggagg aagaggagga ggacgaggag gatctggacc      240

cagatctgga cccagaccta gaggaggaag agaatgatct tggggatcca gctgtacttg      300

gtgctgtcca caacacccag agagctctgc ttagctcccc tggagtcaag gcccctggta      360

tgctgggaat gtcacttgcc tccttgcatt ttctgtggca gaccttggac tacctgtcgc      420

ccatcccttt ctggcctaca tttcccagca ccagctctcc agcacagcac tttggacctc      480

ggctgccctc accagaccca actctcttct gcagcctgct gacctcgtgg ccccctaggt      540

tcagtcatct gacccagctc caccctcggc accaacgaat cttgcagcag cagcagcata      600

gtcaaacacc aagtccccca gccaagaagc cttggtctca gcagccagac ccctatgcta      660

acctcatgac cagaaaagag aaggactggg tgataaaagt gcagatggtg cagctgcaga      720

gtgcaaaacc ccgcctggat gactactatt accaggaata ttaccagaag ctagagaaga      780

agcaggcaga cgaagagcta cttggacgaa gaaaccgggt tgagtccctc aagctggtaa      840

cgccttacat tccgaaggca gaggcttatg agtccgtggt ccgaatcgag ggttccctgg      900

gccaggtagc tgtgtcgaca tgcttcagcc ctcgccgagc tattgatgcg gtaccccatg      960

gaactcaaga gcaggatata gaagctgcaa gcagtcagag gcttcgggta ttataccgga     1020

ttgagaagat gttccttcag ttactagaaa tagaggaagg ctggaagtat aggcctccac     1080

cgccctgctt ttctgagcag caaagcaacc aggttgagaa gctcttccag accttaaaga     1140

cccaggagca gaacaacctg gaagaggcag cagatggctt cctgcaggtg ctctctgtga     1200

ggaaggggaa ggccctggtg gcccggctgc tccccttcct gccccaggat caggctgtta     1260

ccattctttt ggctatcacc caccatctgc ccctcctggt ccggagggat gtggctgatc     1320

aggccctaca aatgttattc aaacctctgg gcaaatgtat tagtcacttg accctccacg     1380

aactcctcca aggacttcag ggattaacgc tgttgccacc tggctcctca gagcggccag     1440

tcaccgtggt gcttcagaat cagtttggaa tatctttgct ctatgccctg ctgagccatg     1500

gggagcaact ggtatcgctg cattcttccc tagaggaacc caacagtgac catacagctt     1560

ggacagacat ggtggttctg attgcctggg agatagccca aatgcctaca gcctctctgg     1620

cagaacccct agctttcccc agcaacctac ttcccctgtt ctgtcaccac gtggacaaac     1680

aattggttca gcagctggag gccaggatgg agtttgcctg gatttactga tctgtttgtt     1740

ctggaatacg tgtatgtggg aagttgaatc atcagacact agctacatag actatgttta     1800

cagggatcca gagagtctga agacatttct tatgccttta tatattggag aacccttccc     1860

cattttcata tcctttcttc aaaaatctaa atgatgtgcc taaaaataag acatggcata     1920

ataaggtata attaaagaga taatagaatg aaaaaaaaaa aaaaaaa                   1967


<210>  84
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  84

Met His Lys Glu Glu His Glu Val Ala Val Leu Gly Pro Pro Pro Ser 
1               5                   10                  15      


Thr Ile Leu Pro Arg Ser Thr Val Ile Asn Ile His Ser Glu Thr Ser 
            20                  25                  30          


Val Pro Asp His Val Val Trp Ser Leu Phe Asn Thr Leu Phe Leu Asn 
        35                  40                  45              


Trp Cys Cys Leu Gly Phe Ile Ala Phe Ala Tyr Ser Val Lys Ser Arg 
    50                  55                  60                  


Asp Arg Lys Met Val Gly Asp Val Thr Gly Ala Gln Ala Tyr Ala Ser 
65                  70                  75                  80  


Thr Ala Lys Cys Leu Asn Ile Trp Ala Leu Ile Leu Gly Ile Leu Met 
                85                  90                  95      


Thr Ile Gly Phe Ile Leu Leu Leu Val Phe Gly Ser Val Thr Val Tyr 
            100                 105                 110         


His Ile Met Leu Gln Ile Ile Gln Glu Lys Arg Gly Tyr 
        115                 120                 125 


<210>  85
<211>  482
<212>  DNA
<213>  Homo sapiens

<400>  85
gcgggcgccg ctcttttgtt tcttgctgca gcaacgcgag tgggagcacc aggatctcgg       60

gctcggaacg agactgcacg gattgtttta agaaaatggc agacaaacca gacatggggg      120

aaatcgccag cttcgataag gccaagctga agaaaacgga gacgcaggag aagaacaccc      180

tgccgaccaa agagaccatt gagcaggaga agcggagtga aatttcctaa gatcctggag      240

gatttcctac ccccgtcctc ttcgagaccc cagtcgtgat gtggaggaag agccacctgc      300

aagatggaca cgagccacaa gctgcactgt gaacctgggc actccgcgcc gatgccaccg      360

gcctgtgggt ctctgaaggg accccccccc aatcggactg ccaaattctc cggtttgccc      420

cgggatatta tagaaaatta tttgtatgaa taatgaaaat aaaacacacc tcgtggcatg      480

gc                                                                     482


<210>  86
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ala Asp Lys Pro Asp Met Gly Glu Ile Ala Ser Phe Asp Lys Ala 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Thr Leu Pro Thr Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Arg Ser Glu Ile Ser 
        35                  40                  


<210>  87
<211>  1687
<212>  DNA
<213>  Homo sapiens

<400>  87
tgctttctca aaggccccac agtcctccac ttcctgggga ggtagctgca gaataaaacc       60

agcagagact ccttttctcc taaccgtccc ggccaccgct gcctcagcct ctgcctccca      120

gcctctttct gagggaaagg acaagatgaa gtggaaggcg cttttcaccg cggccatcct      180

gcaggcacag ttgccgatta cagaggcaca gagctttggc ctgctggatc ccaaactctg      240

ctacctgctg gatggaatcc tcttcatcta tggtgtcatt ctcactgcct tgttcctgag      300

agtgaagttc agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta      360

taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg      420

ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga      480

actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg      540

gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta      600

cgacgccctt cacatgcagg ccctgccccc tcgctaacag ccaggggatt tcaccactca      660

aaggccagac ctgcagacgc ccagattatg agacacagga tgaagcattt acaacccggt      720

tcactcttct cagccactga agtattcccc tttatgtaca ggatgctttg gttatattta      780

gctccaaacc ttcacacaca gactgttgtc cctgcactct ttaagggagt gtactcccag      840

ggcttacggc cctggccttg ggccctctgg tttgccggtg gtgcaggtag acctgtctcc      900

tggcggttcc tcgttctccc tgggaggcgg gcgcactgcc tctcacagct gagttgttga      960

gtctgttttg taaagtcccc agagaaagcg cagatgctag cacatgccct aatgtctgta     1020

tcactctgtg tctgagtggc ttcactcctg ctgtaaattt ggcttctgtt gtcaccttca     1080

cctcctttca aggtaactgt actgggccat gttgtgcctc cctggtgaga gggccgggca     1140

gaggggcaga tggaaaggag cctaggccag gtgcaaccag ggagctgcag gggcatggga     1200

aggtgggcgg gcaggggagg gtcagccagg gcctgcgagg gcagcgggag cctccctgcc     1260

tcaggcctct gtgccgcacc attgaactgt accatgtgct acaggggcca gaagatgaac     1320

agactgacct tgatgagctg tgcacaaagt ggcataaaaa acatgtggtt acacagtgtg     1380

aataaagtgc tgcggagcaa gaggaggccg ttgattcact tcacgctttc agcgaatgac     1440

aaaatcatct ttgtgaaggc ctcgcaggaa gacccaacac atgggaccta taactgccca     1500

gcggacagtg gcaggacagg aaaaacccgt caatgtacta ggatactgct gcgtcattac     1560

agggcacagg ccatggatgg aaaacgctct ctgctctgct ttttttctac tgttttaatt     1620

tatactggca tgctaaagcc ttcctatttt gcataataaa tgcttcagtg aaaatgcaaa     1680

aaaaaaa                                                               1687


<210>  88
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  89
<211>  4507
<212>  DNA
<213>  Homo sapiens

<400>  89
gaccaattgt catacgactt gcagtgagcg tcaggagcac gtccaggaac tcctcagcag       60

cgcctccttc agctccacag ccagacgccc tcagacagca aagcctaccc ccgcgccgcg      120

ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct gtgcgcggtc ctggcgctca      180

gccatacagc aaatccttgc tgttcccacc catgtcaaaa ccgaggtgta tgtatgagtg      240

tgggatttga ccagtataag tgcgattgta cccggacagg attctatgga gaaaactgct      300

caacaccgga atttttgaca agaataaaat tatttctgaa acccactcca aacacagtgc      360

actacatact tacccacttc aagggatttt ggaacgttgt gaataacatt cccttccttc      420

gaaatgcaat tatgagttat gtgttgacat ccagatcaca tttgattgac agtccaccaa      480

cttacaatgc tgactatggc tacaaaagct gggaagcctt ctctaacctc tcctattata      540

ctagagccct tcctcctgtg cctgatgatt gcccgactcc cttgggtgtc aaaggtaaaa      600

agcagcttcc tgattcaaat gagattgtgg aaaaattgct tctaagaaga aagttcatcc      660

ctgatcccca gggctcaaac atgatgtttg cattctttgc ccagcacttc acgcatcagt      720

ttttcaagac agatcataag cgagggccag ctttcaccaa cgggctgggc catggggtgg      780

acttaaatca tatttacggt gaaactctgg ctagacagcg taaactgcgc cttttcaagg      840

atggaaaaat gaaatatcag ataattgatg gagagatgta tcctcccaca gtcaaagata      900

ctcaggcaga gatgatctac cctcctcaag tccctgagca tctacggttt gctgtggggc      960

aggaggtctt tggtctggtg cctggtctga tgatgtatgc cacaatctgg ctgcgggaac     1020

acaacagagt atgcgatgtg cttaaacagg agcatcctga atggggtgat gagcagttgt     1080

tccagacaag caggctaata ctgataggag agactattaa gattgtgatt gaagattatg     1140

tgcaacactt gagtggctat cacttcaaac tgaaatttga cccagaacta cttttcaaca     1200

aacaattcca gtaccaaaat cgtattgctg ctgaatttaa caccctctat cactggcatc     1260

cccttctgcc tgacaccttt caaattcatg accagaaata caactatcaa cagtttatct     1320

acaacaactc tatattgctg gaacatggaa ttacccagtt tgttgaatca ttcaccaggc     1380

aaattgctgg cagggttgct ggtggtagga atgttccacc cgcagtacag aaagtatcac     1440

aggcttccat tgaccagagc aggcagatga aataccagtc ttttaatgag taccgcaaac     1500

gctttatgct gaagccctat gaatcatttg aagaacttac aggagaaaag gaaatgtctg     1560

cagagttgga agcactctat ggtgacatcg atgctgtgga gctgtatcct gcccttctgg     1620

tagaaaagcc tcggccagat gccatctttg gtgaaaccat ggtagaagtt ggagcaccat     1680

tctccttgaa aggacttatg ggtaatgtta tatgttctcc tgcctactgg aagccaagca     1740

cttttggtgg agaagtgggt tttcaaatca tcaacactgc ctcaattcag tctctcatct     1800

gcaataacgt gaagggctgt ccctttactt cattcagtgt tccagatcca gagctcatta     1860

aaacagtcac catcaatgca agttcttccc gctccggact agatgatatc aatcccacag     1920

tactactaaa agaacgttcg actgaactgt agaagtctaa tgatcatatt tatttattta     1980

tatgaaccat gtctattaat ttaattattt aataatattt atattaaact ccttatgtta     2040

cttaacatct tctgtaacag aagtcagtac tcctgttgcg gagaaaggag tcatacttgt     2100

gaagactttt atgtcactac tctaaagatt ttgctgttgc tgttaagttt ggaaaacagt     2160

ttttattctg ttttataaac cagagagaaa tgagttttga cgtcttttta cttgaatttc     2220

aacttatatt ataagaacga aagtaaagat gtttgaatac ttaaacactg tcacaagatg     2280

gcaaaatgct gaaagttttt acactgtcga tgtttccaat gcatcttcca tgatgcatta     2340

gaagtaacta atgtttgaaa ttttaaagta cttttggtta tttttctgtc atcaaacaaa     2400

aacaggtatc agtgcattat taaatgaata tttaaattag acattaccag taatttcatg     2460

tctacttttt aaaatcagca atgaaacaat aatttgaaat ttctaaattc atagggtaga     2520

atcacctgta aaagcttgtt tgatttctta aagttattaa acttgtacat ataccaaaaa     2580

gaagctgtct tggatttaaa tctgtaaaat cagtagaaat tttactacaa ttgcttgtta     2640

aaatatttta taagtgatgt tcctttttca ccaagagtat aaaccttttt agtgtgactg     2700

ttaaaacttc cttttaaatc aaaatgccaa atttattaag gtggtggagc cactgcagtg     2760

ttatcttaaa ataagaatat tttgttgaga tattccagaa tttgtttata tggctggtaa     2820

catgtaaaat ctatatcagc aaaagggtct acctttaaaa taagcaataa caaagaagaa     2880

aaccaaatta ttgttcaaat ttaggtttaa acttttgaag caaacttttt tttatccttg     2940

tgcactgcag gcctggtact cagattttgc tatgaggtta atgaagtacc aagctgtgct     3000

tgaataatga tatgttttct cagattttct gttgtacagt ttaatttagc agtccatatc     3060

acattgcaaa agtagcaatg acctcataaa atacctcttc aaaatgctta aattcatttc     3120

acacattaat tttatctcag tcttgaagcc aattcagtag gtgcattgga atcaagcctg     3180

gctacctgca tgctgttcct tttcttttct tcttttagcc attttgctaa gagacacagt     3240

cttctcatca cttcgtttct cctattttgt tttactagtt ttaagatcag agttcacttt     3300

ctttggactc tgcctatatt ttcttacctg aacttttgca agttttcagg taaacctcag     3360

ctcaggactg ctatttagct cctcttaaga agattaaaag agaaaaaaaa aggccctttt     3420

aaaaatagta tacacttatt ttaagtgaaa agcagagaat tttatttata gctaatttta     3480

gctatctgta accaagatgg atgcaaagag gctagtgcct cagagagaac tgtacggggt     3540

ttgtgactgg aaaaagttac gttcccattc taattaatgc cctttcttat ttaaaaacaa     3600

aaccaaatga tatctaagta gttctcagca ataataataa tgacgataat acttcttttc     3660

cacatctcat tgtcactgac atttaatggt actgtatatt acttaattta ttgaagatta     3720

ttatttatgt cttattagga cactatggtt ataaactgtg tttaagccta caatcattga     3780

tttttttttg ttatgtcaca atcagtatat tttctttggg gttacctctc tgaatattat     3840

gtaaacaatc caaagaaatg attgtattaa gatttgtgaa taaattttta gaaatctgat     3900

tggcatattg agatatttaa ggttgaatgt ttgtccttag gataggccta tgtgctagcc     3960

cacaaagaat attgtctcat tagcctgaat gtgccataag actgaccttt taaaatgttt     4020

tgagggatct gtggatgctt cgttaatttg ttcagccaca atttattgag aaaatattct     4080

gtgtcaagca ctgtgggttt taatattttt aaatcaaacg ctgattacag ataatagtat     4140

ttatataaat aattgaaaaa aattttcttt tgggaagagg gagaaaatga aataaatatc     4200

attaaagata actcaggaga atcttcttta caattttacg tttagaatgt ttaaggttaa     4260

gaaagaaata gtcaatatgc ttgtataaaa cactgttcac tgtttttttt aaaaaaaaaa     4320

cttgatttgt tattaacatt gatctgctga caaaacctgg gaatttgggt tgtgtatgcg     4380

aatgtttcag tgcctcagac aaatgtgtat ttaacttatg taaaagataa gtctggaaat     4440

aaatgtctgt ttatttttgt actatttaaa aattgacaga tcttttctga agaaaaaaaa     4500

aaaaaaa                                                               4507


<210>  90
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210>  91
<211>  5045
<212>  DNA
<213>  Homo sapiens

<400>  91
atgggctgga gctccgggca gtgtgcgagg cgcacgcaca ggagcctgca ctctgcgtcc       60

cgcaccccag cagccgcgcc atgagccgga gtctcttgct ctggttcttg ctgttcctgc      120

tcctgctccc gccgctcccc gtcctgctcg cggacccagg ggcgcccacg ccagtgaatc      180

cctgttgtta ctatccatgc cagcaccagg gcatctgtgt ccgcttcggc cttgaccgct      240

accagtgtga ctgcacccgc acgggctatt ccggccccaa ctgcaccatc cctggcctgt      300

ggacctggct ccggaattca ctgcggccca gcccctcttt cacccacttc ctgctcactc      360

acgggcgctg gttctgggag tttgtcaatg ccaccttcat ccgagagatg ctcatgcgcc      420

tggtactcac agtgcgctcc aaccttatcc ccagtccccc cacctacaac tcagcacatg      480

actacatcag ctgggagtct ttctccaacg tgagctatta cactcgtatt ctgccctctg      540

tgcctaaaga ttgccccaca cccatgggaa ccaaagggaa gaagcagttg ccagatgccc      600

agctcctggc ccgccgcttc ctgctcagga ggaagttcat acctgacccc caaggcacca      660

acctcatgtt tgccttcttt gcacaacact tcacccacca gttcttcaaa acttctggca      720

agatgggtcc tggcttcacc aaggccttgg gccatggggt agacctcggc cacatttatg      780

gagacaatct ggagcgtcag tatcaactgc ggctctttaa ggatgggaaa ctcaagtacc      840

aggtgctgga tggagaaatg tacccgccct cggtagaaga ggcgcctgtg ttgatgcact      900

acccccgagg catcccgccc cagagccaga tggctgtggg ccaggaggtg tttgggctgc      960

ttcctgggct catgctgtat gccacgctct ggctacgtga gcacaaccgt gtgtgtgacc     1020

tgctgaaggc tgagcacccc acctggggcg atgagcagct tttccagacg acccgcctca     1080

tcctcatagg ggagaccatc aagattgtca tcgaggagta cgtgcagcag ctgagtggct     1140

atttcctgca gctgaaattt gacccagagc tgctgttcgg tgtccagttc caataccgca     1200

accgcattgc catggagttc aaccatctct accactggca ccccctcatg cctgactcct     1260

tcaaggtggg ctcccaggag tacagctacg agcagttctt gttcaacacc tccatgttgg     1320

tggactatgg ggttgaggcc ctggtggatg ccttctctcg ccagattgct ggccggatcg     1380

gtgggggcag gaacatggac caccacatcc tgcatgtggc tgtggatgtc atcagggagt     1440

ctcgggagat gcggctgcag cccttcaatg agtaccgcaa gaggtttggc atgaaaccct     1500

acacctcctt ccaggagctc gtaggagaga aggagatggc agcagagttg gaggaattgt     1560

atggagacat tgatgcgttg gagttctacc ctggactgct tcttgaaaag tgccatccaa     1620

actctatctt tggggagagt atgatagaga ttggggctcc cttttccctc aagggtctcc     1680

tagggaatcc catctgttct ccggagtact ggaagccgag cacatttggc ggcgaggtgg     1740

gctttaacat tgtcaagacg gccacactga agaagctggt ctgcctcaac accaagacct     1800

gtccctacgt ttccttccgt gtgccggatg ccagtcagga tgatgggcct gctgtggagc     1860

gaccatccac agagctctga ggggcaggaa agcagcattc tggaggggag agctttgtgc     1920

ttgtcattcc agagtgctga ggccagggct gatggtctta aatgctcatt ttctggtttg     1980

gcatggtgag tgttggggtt gacatttaga actttaagtc tcacccatta tctggaatat     2040

tgtgattctg tttattcttc cagaatgctg aactccttgt tagcccttca gattgttagg     2100

agtggttctc atttggtctg ccagaatact gggttcttag ttgacaacct agaatgtcag     2160

atttctggtt gatttgtaac acagtcattc taggatgtgg agctactgat gaaatctgct     2220

agaaagttag ggggttctta ttttgcattc cagaatcttg actttctgat tggtgattca     2280

aagtgttgtg ttcctggctg atgatccaga acagtggctc gtatcccaaa tctgtcagca     2340

tctggctgtc tagaatgtgg atttgattca ttttcctgtt cagtgagata tcatagagac     2400

ggagatccta aggtccaaca agaatgcatt ccctgaatct gtgcctgcac tgagagggca     2460

aggaagtggg gtgttcttct tgggaccccc actaagaccc tggtctgagg atgtagagag     2520

aacaggtggg ctgtattcac gccattggtt ggaagctacc agagctctat ccccatccag     2580

gtcttgactc atggcagctg tttctcatga agctaataaa attcgctttc taaagttacc     2640

tgttatatat ctcttttggt cccatcctct aaagcagagg caacactgga acatggctag     2700

cctttcttgt agccatggct gggcgtgcta gaggttgcag catgagactt tctgctggga     2760

tccttgggcc catcactgta tagacatgct accactggta cttcctttct ccctgcgggc     2820

caggcactgc ccttttcagg aagctctctt aaaataccca ttgccccaga cctggaagat     2880

ataacattca gttcccacca tctgattaaa acaacttcct cccttacaga gcatacaaca     2940

gagggggcac ccggggagga gagcacatac tgtgttccaa tttcacgctt ttaattctca     3000

tttgttctca caccaacagt gtgaagtgcg tggtataatc tccatttcaa aaccaaggaa     3060

gcagcctcag agtggtcgag tgacacacct cacgcaggct gagtccagag cttgtgctcc     3120

tcttgattcc tggtttgact cagttccagg cctgatcttg cctgtctggc tcagggtcaa     3180

agacagaatg gtggagtgta gcctccacct gatattcagg ctactcattc agtcccaaat     3240

atgtattttc ctaagtgttt actatgtgcc agttcctgta acaggtgtgg ggacacagca     3300

gtgagtaatc aatacagaca aggttctgcc cttatggagc tcacactcca gtggcagaca     3360

aacagaccat aaataaggaa acgatgaaat aagatatata caaggtgagt gtgacttccc     3420

ttctaacccc ctctgctctg tcctccccta ttgcgctctc aagaccagag acccaacagc     3480

agtgatctca gggcagacag ccctccactc cagctctgag acccttttct caggacctct     3540

gtaggcagca gagagagagg acagaggggt aagatgaggg gttgagggaa ggttcttcat     3600

gatccacact ttgggcttag tatttctcag gaagagctat ggcccagaaa caacagggga     3660

aactagagtt cggtctgaca gtccttgggg ttaagtctcc tgtcttatgg tccagaaact     3720

cctgtttctc cttagttggc tggaaactgc tcccatcatt ccttctggcc tctgctgaat     3780

gcagggaatg caatccttcc ctgctcttgc agttgctctg acgtagaaag atccttcggg     3840

tgctggaagt ctccatgaag agcttgtgtc ctgtcctttc ttgcagattc tatttcccct     3900

cttctgctaa tacctcttac tttgcttgag aatcctctcc tttcttatta atttcagtct     3960

tggtggttct atcaggggtg cattctggcc aaggggtggg cctgtgaatc aatcctgggc     4020

aatcagacac cctctcctta aaaactggcc cgtggagact gagatcactg actctgactc     4080

atccccacag ctggctctga caagatggtc catttgttcc tgcttccgag atccccaggg     4140

cagcctggat ccctgccctt ctcaagactt tagcttttcc ttccatccgg tggcctattc     4200

caggaattcc tcttttgctt aaatcagttg gagtttgtgt ctgttgcttg taatcaagcc     4260

tttatggctg ctgggctgag tgacacaagc actttaatgg cctggaggga cttttaatca     4320

gtgaagatgc aatcagacaa gtgttttgga aagagcaccc tcgagaaggg tggatgacag     4380

ggcagagcag gaaggacagg aagctggcag aacggaggag gctgcagccg tggtccaacc     4440

aggagctgat ggcagctggg gctaggggaa gggctttgag ggtggaagga tgggatgggt     4500

tccagaggta ttcctctctt aaatgcaagt gcctagatta ggtagacttt gcttagtatt     4560

gacaactgca catgaaagtt ttgcaaaggg aaacaggcta aatgcaccaa gaaagcttct     4620

tcagagtgaa gaatcttaat gcttgtaatt taaacatttg ttcctggagt tttgatttgg     4680

tggatgtgat ggttggtttt atttgtcagt ttggttgggc tatagcacac agttatttaa     4740

tcaaacagta atctaggtgt ggctgtgaag gtattttgta gatgtgatta acatctacaa     4800

tcagttgact ttaagtgaaa gagattactt aaataatttg ggtgagctgc acctgattag     4860

ttgaaaggcc tcaagaacaa acactgcagt ttcctggaaa agaagaaact ttgcctcaag     4920

actatagcca tcgactcctg cctgagtttc cagcctgcta gtctgcccta tggatttgaa     4980

gtttgccaac cccaacaatt gtgtgaatta atttctaaaa ataaagctat atacagccaa     5040

aaaaa                                                                 5045


<210>  92
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ser Arg Ser Leu Leu Leu Trp Phe Leu Leu Phe Leu Leu Leu Leu 
1               5                   10                  15      


Pro Pro Leu Pro Val Leu Leu Ala Asp Pro Gly Ala Pro Thr Pro Val 
            20                  25                  30          


Asn Pro Cys Cys Tyr Tyr Pro Cys Gln His Gln Gly Ile Cys Val Arg 
        35                  40                  45              


Phe Gly Leu Asp Arg Tyr Gln Cys Asp Cys Thr Arg Thr Gly Tyr Ser 
    50                  55                  60                  


Gly Pro Asn Cys Thr Ile Pro Gly Leu Trp Thr Trp Leu Arg Asn Ser 
65                  70                  75                  80  


Leu Arg Pro Ser Pro Ser Phe Thr His Phe Leu Leu Thr His Gly Arg 
                85                  90                  95      


Trp Phe Trp Glu Phe Val Asn Ala Thr Phe Ile Arg Glu Met Leu Met 
            100                 105                 110         


Arg Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser Pro Pro Thr 
        115                 120                 125             


Tyr Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe Ser Asn Val 
    130                 135                 140                 


Ser Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp Cys Pro Thr 
145                 150                 155                 160 


Pro Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala Gln Leu Leu 
                165                 170                 175     


Ala Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp Pro Gln Gly 
            180                 185                 190         


Thr Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe 
        195                 200                 205             


Phe Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys Ala Leu Gly 
    210                 215                 220                 


His Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu Glu Arg Gln 
225                 230                 235                 240 


Tyr Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr Gln Val Leu 
                245                 250                 255     


Asp Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro Val Leu Met 
            260                 265                 270         


His Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala Val Gly Gln 
        275                 280                 285             


Glu Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala Thr Leu Trp 
    290                 295                 300                 


Leu Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala Glu His Pro 
305                 310                 315                 320 


Thr Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu Ile Leu Ile 
                325                 330                 335     


Gly Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln Gln Leu Ser 
            340                 345                 350         


Gly Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu Phe Gly Val 
        355                 360                 365             


Gln Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn His Leu Tyr 
    370                 375                 380                 


His Trp His Pro Leu Met Pro Asp Ser Phe Lys Val Gly Ser Gln Glu 
385                 390                 395                 400 


Tyr Ser Tyr Glu Gln Phe Leu Phe Asn Thr Ser Met Leu Val Asp Tyr 
                405                 410                 415     


Gly Val Glu Ala Leu Val Asp Ala Phe Ser Arg Gln Ile Ala Gly Arg 
            420                 425                 430         


Ile Gly Gly Gly Arg Asn Met Asp His His Ile Leu His Val Ala Val 
        435                 440                 445             


Asp Val Ile Arg Glu Ser Arg Glu Met Arg Leu Gln Pro Phe Asn Glu 
    450                 455                 460                 


Tyr Arg Lys Arg Phe Gly Met Lys Pro Tyr Thr Ser Phe Gln Glu Leu 
465                 470                 475                 480 


Val Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu Tyr Gly Asp 
                485                 490                 495     


Ile Asp Ala Leu Glu Phe Tyr Pro Gly Leu Leu Leu Glu Lys Cys His 
            500                 505                 510         


Pro Asn Ser Ile Phe Gly Glu Ser Met Ile Glu Ile Gly Ala Pro Phe 
        515                 520                 525             


Ser Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro Glu Tyr Trp 
    530                 535                 540                 


Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Asn Ile Val Lys Thr 
545                 550                 555                 560 


Ala Thr Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr Cys Pro Tyr 
                565                 570                 575     


Val Ser Phe Arg Val Pro Asp Ala Ser Gln Asp Asp Gly Pro Ala Val 
            580                 585                 590         


Glu Arg Pro Ser Thr Glu Leu 
        595                 


<210>  93
<211>  813
<212>  DNA
<213>  Homo sapiens

<400>  93
acccgcgcct gaccgcggca gctcccacca tggcggagac caagctccag ctgtttgtca       60

aggcgagtga ggacggggag agcgtgggtc actgcccctc ctgccagcgg ctcttcatgg      120

tcctgctcct caagggcgta cctttcaccc tcaccacggt ggacacgcgc aggtccccgg      180

acgtgctgaa ggacttcgcc cccggctcgc agctgcccat cctgctctat gacagcgacg      240

ccaagacaga cacgctgcag atcgaggact ttctggagga gacgctgggg ccgcccgact      300

tccccagcct ggcgcctcgt tacagggagt ccaacaccgc cggcaacgac gttttccaca      360

agttctccgc gttcatcaag aacccggtgc ccgcgcagga cgaagccctg taccagcagc      420

tgctgcgcgc cctcgccagg ctggacagct acctgcgcgc gcccctggag cacgagctgg      480

cgggggagcc gcagctgcgc gagtcccgcc gccgcttcct ggacggcgac aggctcacgc      540

tggccgactg cagcctcctg cccaagctgc acatcgtcga cacggtgtgc gcgcacttcc      600

gccaggcgcc catccccgcg gagctgcgcg gcgtacgccg ctacctggac agcgcgatgc      660

aggagaaaga gttcaaatac acgtgtccgc acagcgccga gatcctggcg gcctaccggc      720

ccgccgtgca cccccgctag cgccccaccc cgcgtctgtc gcccaataaa ggcatctttg      780

tcgggagtga gggtgtcctg acatctgaag ggc                                   813


<210>  94
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Glu Thr Lys Leu Gln Leu Phe Val Lys Ala Ser Glu Asp Gly 
1               5                   10                  15      


Glu Ser Val Gly His Cys Pro Ser Cys Gln Arg Leu Phe Met Val Leu 
            20                  25                  30          


Leu Leu Lys Gly Val Pro Phe Thr Leu Thr Thr Val Asp Thr Arg Arg 
        35                  40                  45              


Ser Pro Asp Val Leu Lys Asp Phe Ala Pro Gly Ser Gln Leu Pro Ile 
    50                  55                  60                  


Leu Leu Tyr Asp Ser Asp Ala Lys Thr Asp Thr Leu Gln Ile Glu Asp 
65                  70                  75                  80  


Phe Leu Glu Glu Thr Leu Gly Pro Pro Asp Phe Pro Ser Leu Ala Pro 
                85                  90                  95      


Arg Tyr Arg Glu Ser Asn Thr Ala Gly Asn Asp Val Phe His Lys Phe 
            100                 105                 110         


Ser Ala Phe Ile Lys Asn Pro Val Pro Ala Gln Asp Glu Ala Leu Tyr 
        115                 120                 125             


Gln Gln Leu Leu Arg Ala Leu Ala Arg Leu Asp Ser Tyr Leu Arg Ala 
    130                 135                 140                 


Pro Leu Glu His Glu Leu Ala Gly Glu Pro Gln Leu Arg Glu Ser Arg 
145                 150                 155                 160 


Arg Arg Phe Leu Asp Gly Asp Arg Leu Thr Leu Ala Asp Cys Ser Leu 
                165                 170                 175     


Leu Pro Lys Leu His Ile Val Asp Thr Val Cys Ala His Phe Arg Gln 
            180                 185                 190         


Ala Pro Ile Pro Ala Glu Leu Arg Gly Val Arg Arg Tyr Leu Asp Ser 
        195                 200                 205             


Ala Met Gln Glu Lys Glu Phe Lys Tyr Thr Cys Pro His Ser Ala Glu 
    210                 215                 220                 


Ile Leu Ala Ala Tyr Arg Pro Ala Val His Pro Arg 
225                 230                 235     


<210>  95
<211>  512
<212>  DNA
<213>  Homo sapiens

<400>  95
attcttcccc tctctacaac cctctctcct cagcgcttct tctttcttgg tttgatcctg       60

actgctgtca tggcgtgccc tctggagaag gccctggatg tgatggtgtc caccttccac      120

aagtactcgg gcaaagaggg tgacaagttc aagctcaaca agtcagaact aaaggagctg      180

ctgacccggg agctgcccag cttcttgggg aaaaggacag atgaagctgc tttccagaag      240

ctgatgagca acttggacag caacagggac aacgaggtgg acttccaaga gtactgtgtc      300

ttcctgtcct gcatcgccat gatgtgtaac gaattctttg aaggcttccc agataagcag      360

cccaggaaga aatgaaaact cctctgatgt ggttgggggg tctgccagct ggggccctcc      420

ctgtcgccag tgggcacttt tttttttcca ccctggctcc ttcagacacg tgcttgatgc      480

tgagcaagtt caataaagat tcttggaagt tt                                    512


<210>  96
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Cys Pro Leu Glu Lys Ala Leu Asp Val Met Val Ser Thr Phe 
1               5                   10                  15      


His Lys Tyr Ser Gly Lys Glu Gly Asp Lys Phe Lys Leu Asn Lys Ser 
            20                  25                  30          


Glu Leu Lys Glu Leu Leu Thr Arg Glu Leu Pro Ser Phe Leu Gly Lys 
        35                  40                  45              


Arg Thr Asp Glu Ala Ala Phe Gln Lys Leu Met Ser Asn Leu Asp Ser 
    50                  55                  60                  


Asn Arg Asp Asn Glu Val Asp Phe Gln Glu Tyr Cys Val Phe Leu Ser 
65                  70                  75                  80  


Cys Ile Ala Met Met Cys Asn Glu Phe Phe Glu Gly Phe Pro Asp Lys 
                85                  90                  95      


Gln Pro Arg Lys Lys 
            100     


<210>  97
<211>  778
<212>  DNA
<213>  Homo sapiens

<400>  97
ggcggggttc ggccgggagc gcaggggcgg cagtgcgcgc ctagcagtgt cccagccggg       60

ttcgtgtcgc catggggcag atcgagtggg ccatgtgggc caacgagcag gcgctggcgt      120

ccggcctgat cctcatcacc gggggcatcg tggccacagc tgggcgcttc acccagtggt      180

actttggtgc ctactccatt gtggcgggcg tgtttgtgtg cctgctggag tacccccggg      240

ggaagaggaa gaagggctcc accatggagc gctggggaca gaagtacatg accgccgtgg      300

tgaagctgtt cgggcccttt accaggaatt actatgttcg ggccgtcctg catctcctgc      360

tctcggtgcc cgccggcttc ctgctggcca ccatccttgg gaccgcctgc ctggccattg      420

cgagcggcat ctacctactg gcggctgtgc gtggcgagca gtggacgccc atcgagccca      480

agccccggga gcggccgcag atcggaggca ccatcaagca gccgcccagc aaccccccgc      540

cgcggccccc ggccgaggcc cgcaagaagc ccagcgagga ggaggctgcg gtggcggcgg      600

ggggaccccc gggaggtccc caggtcaacc ccatcccggt gaccgacgag gtcgtgtgac      660

ctcgccccgg acctgccctc ccgccaggtg cacccacctg caataaatgc agcgaagccg      720

ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa        778


<210>  98
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Gly Gln Ile Glu Trp Ala Met Trp Ala Asn Glu Gln Ala Leu Ala 
1               5                   10                  15      


Ser Gly Leu Ile Leu Ile Thr Gly Gly Ile Val Ala Thr Ala Gly Arg 
            20                  25                  30          


Phe Thr Gln Trp Tyr Phe Gly Ala Tyr Ser Ile Val Ala Gly Val Phe 
        35                  40                  45              


Val Cys Leu Leu Glu Tyr Pro Arg Gly Lys Arg Lys Lys Gly Ser Thr 
    50                  55                  60                  


Met Glu Arg Trp Gly Gln Lys Tyr Met Thr Ala Val Val Lys Leu Phe 
65                  70                  75                  80  


Gly Pro Phe Thr Arg Asn Tyr Tyr Val Arg Ala Val Leu His Leu Leu 
                85                  90                  95      


Leu Ser Val Pro Ala Gly Phe Leu Leu Ala Thr Ile Leu Gly Thr Ala 
            100                 105                 110         


Cys Leu Ala Ile Ala Ser Gly Ile Tyr Leu Leu Ala Ala Val Arg Gly 
        115                 120                 125             


Glu Gln Trp Thr Pro Ile Glu Pro Lys Pro Arg Glu Arg Pro Gln Ile 
    130                 135                 140                 


Gly Gly Thr Ile Lys Gln Pro Pro Ser Asn Pro Pro Pro Arg Pro Pro 
145                 150                 155                 160 


Ala Glu Ala Arg Lys Lys Pro Ser Glu Glu Glu Ala Ala Val Ala Ala 
                165                 170                 175     


Gly Gly Pro Pro Gly Gly Pro Gln Val Asn Pro Ile Pro Val Thr Asp 
            180                 185                 190         


Glu Val Val 
        195 


<210>  99
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  99

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  100
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  100

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  101
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  101

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


