                         SEQUENCE LISTING

<110>  PRESIDENT AND FELLOWS OF HARVARD COLLEGE
       THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120>  SYNTHETIC DERIVATIVES OF CHOLIC ACID 7-SULFATE AND USES THEREOF

<130>  H0824.70356WO00

<140>  PCT/US2019/064488
<141>  2019-12-04

<150>  US 62/775,029
<151>  2018-12-04

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1743
<212>  DNA
<213>  Homo sapiens

<400>  1
ctttccgcct agtgagaggc ggtccgattt ggcccttggg gagtgtccgt cgcgttgatc       60

tgatggattc acgtacacaa caccacattc tatgagattt tgcaggcaaa agtccacaag      120

ctcgatatat gggacacctg caccggcatt ggatttggcc ccgcaacatc ttaaaggaag      180

caggctgtga gccaagggga aggcagagga cagaaatgaa tgtgtttcca ggctttcctg      240

gtggtttatg gcattctcca aactcctatg caagggctat tcctgaccaa gaagatctaa      300

agagaacgtc tctgaaatca agtccggatg aagaattaag agaaaaaaag tgaatatggt      360

ttttgctcac agaatggata acagcaagcc acatttgatt attcctacac ttctggtgcc      420

cctccaaaac cgcagctgca ctgaaacagc cacacctctg ccaagccaat acctgatgga      480

attaagtgag gagcacagtt ggatgagcaa ccaaacagac cttcactatg tgctgaaacc      540

cggggaagtg gccacagcca gcatcttctt tgggattctg tggttgtttt ctatcttcgg      600

caattccctg gtttgtttgg tcatccatag gagtaggagg actcagtcta ccaccaacta      660

ctttgtggtc tccatggcat gtgctgacct tctcatcagc gttgccagca cgcctttcgt      720

cctgctccag ttcaccactg gaaggtggac gctgggtagt gcaacgtgca aggttgtgcg      780

atattttcaa tatctcactc caggtgtcca gatctacgtt ctcctctcca tctgcataga      840

ccggttctac accatcgtct atcctctgag cttcaaggtg tccagagaaa aagccaagaa      900

aatgattgcg gcatcgtgga tctttgatgc aggctttgtg acccctgtgc tctttttcta      960

tggctccaac tgggacagtc attgtaacta tttcctcccc tcctcttggg aaggcactgc     1020

ctacactgtc atccacttct tggtgggctt tgtgattcca tctgtcctca taattttatt     1080

ttaccaaaag gtcataaaat atatttggag aataggcaca gatggccgaa cggtgaggag     1140

gacaatgaac attgtccctc ggacaaaagt gaaaactatc aagatgttcc tcattttaaa     1200

tctgttgttt ttgctctcct ggctgccttt tcatgtagct cagctatggc acccccatga     1260

acaagactat aagaaaagtt cccttgtttt cacagctatc acatggatat cctttagttc     1320

ttcagcctct aaacctactc tgtattcaat ttataatgcc aattttcgga gagggatgaa     1380

agagactttt tgcatgtcct ctatgaaatg ttaccgaagc aatgcctata ctatcacaac     1440

aagttcaagg atggccaaaa aaaactacgt tggcatttca gaaatccctt ccatggccaa     1500

aactattacc aaagactcga tctatgactc atttgacaga gaagccaagg aaaaaaagct     1560

tgcttggccc attaactcaa atccaccaaa tacttttgtc taagttctca ttctttcaat     1620

tgttatgcac cagagattaa aaagctttaa ctataaaaac agaagctatt tacatatttg     1680

ttttcactca actttccaag ggaaatgttt tattttgtaa aatgcattca tttgtttact     1740

gta                                                                   1743


<210>  2
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Phe Ala His Arg Met Asp Asn Ser Lys Pro His Leu Ile Ile 
1               5                   10                  15      


Pro Thr Leu Leu Val Pro Leu Gln Asn Arg Ser Cys Thr Glu Thr Ala 
            20                  25                  30          


Thr Pro Leu Pro Ser Gln Tyr Leu Met Glu Leu Ser Glu Glu His Ser 
        35                  40                  45              


Trp Met Ser Asn Gln Thr Asp Leu His Tyr Val Leu Lys Pro Gly Glu 
    50                  55                  60                  


Val Ala Thr Ala Ser Ile Phe Phe Gly Ile Leu Trp Leu Phe Ser Ile 
65                  70                  75                  80  


Phe Gly Asn Ser Leu Val Cys Leu Val Ile His Arg Ser Arg Arg Thr 
                85                  90                  95      


Gln Ser Thr Thr Asn Tyr Phe Val Val Ser Met Ala Cys Ala Asp Leu 
            100                 105                 110         


Leu Ile Ser Val Ala Ser Thr Pro Phe Val Leu Leu Gln Phe Thr Thr 
        115                 120                 125             


Gly Arg Trp Thr Leu Gly Ser Ala Thr Cys Lys Val Val Arg Tyr Phe 
    130                 135                 140                 


Gln Tyr Leu Thr Pro Gly Val Gln Ile Tyr Val Leu Leu Ser Ile Cys 
145                 150                 155                 160 


Ile Asp Arg Phe Tyr Thr Ile Val Tyr Pro Leu Ser Phe Lys Val Ser 
                165                 170                 175     


Arg Glu Lys Ala Lys Lys Met Ile Ala Ala Ser Trp Ile Phe Asp Ala 
            180                 185                 190         


Gly Phe Val Thr Pro Val Leu Phe Phe Tyr Gly Ser Asn Trp Asp Ser 
        195                 200                 205             


His Cys Asn Tyr Phe Leu Pro Ser Ser Trp Glu Gly Thr Ala Tyr Thr 
    210                 215                 220                 


Val Ile His Phe Leu Val Gly Phe Val Ile Pro Ser Val Leu Ile Ile 
225                 230                 235                 240 


Leu Phe Tyr Gln Lys Val Ile Lys Tyr Ile Trp Arg Ile Gly Thr Asp 
                245                 250                 255     


Gly Arg Thr Val Arg Arg Thr Met Asn Ile Val Pro Arg Thr Lys Val 
            260                 265                 270         


Lys Thr Ile Lys Met Phe Leu Ile Leu Asn Leu Leu Phe Leu Leu Ser 
        275                 280                 285             


Trp Leu Pro Phe His Val Ala Gln Leu Trp His Pro His Glu Gln Asp 
    290                 295                 300                 


Tyr Lys Lys Ser Ser Leu Val Phe Thr Ala Ile Thr Trp Ile Ser Phe 
305                 310                 315                 320 


Ser Ser Ser Ala Ser Lys Pro Thr Leu Tyr Ser Ile Tyr Asn Ala Asn 
                325                 330                 335     


Phe Arg Arg Gly Met Lys Glu Thr Phe Cys Met Ser Ser Met Lys Cys 
            340                 345                 350         


Tyr Arg Ser Asn Ala Tyr Thr Ile Thr Thr Ser Ser Arg Met Ala Lys 
        355                 360                 365             


Lys Asn Tyr Val Gly Ile Ser Glu Ile Pro Ser Met Ala Lys Thr Ile 
    370                 375                 380                 


Thr Lys Asp Ser Ile Tyr Asp Ser Phe Asp Arg Glu Ala Lys Glu Lys 
385                 390                 395                 400 


Lys Leu Ala Trp Pro Ile Asn Ser Asn Pro Pro Asn Thr Phe Val 
                405                 410                 415 


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


