                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Moore, Bradley S.
       Chekan, Jonathan R.
       McKinnie, Shaun M.K.
 
<120>  Scalable Biosynthesis of the Seaweed Neurochemical Kainic Acid

<130>  037866-638001WO

<140>  PCT/US 19/064221
<141>  2019-12-03

<150>  US 62/775,327
<151>  2018-12-04

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  PRT
<213>  Digenea simplex

<400>  1

Met Thr Val Ser Lys Tyr Asn Gly Val Ala Ser Thr Phe Asn Gly Val 
1               5                   10                  15      


Ala Arg Arg Phe Asp Phe Ala Pro Leu Glu Ala Asp Lys Leu Asn Trp 
            20                  25                  30          


Tyr Pro Arg Ser Ala Leu Pro Pro Glu Ile Pro Ala Ile Asp Leu Asn 
        35                  40                  45              


Lys Val Asn Thr Glu Glu Glu Leu Ala Gln Phe Leu Val Asp Ile Arg 
    50                  55                  60                  


Lys Ser Gly Leu Phe Tyr Ile Val Asp His Gly Ile Pro Glu Glu Ile 
65                  70                  75                  80  


Ser Ile Gly Cys Tyr Asn Ala Phe Arg Glu Phe Cys Asn Leu Pro Glu 
                85                  90                  95      


Glu Ala Arg Glu Lys Tyr Asn Thr Asp Glu Ser Phe Lys Ser Gly Gly 
            100                 105                 110         


Tyr Val Pro Phe Lys Gly Thr Ser Ile Gly Gly Gly Asn Leu Phe Glu 
        115                 120                 125             


Arg Gln Lys Asp Phe Val Val Lys Phe Phe Trp Arg Gly Pro Ser Val 
    130                 135                 140                 


Val Asn Arg Ser Pro Asn Asp Arg Phe Ala Glu Phe His Asp Glu His 
145                 150                 155                 160 


His Arg Lys Thr Ala Glu Leu Ala Glu Lys Ile Ile Thr Thr Ile Leu 
                165                 170                 175     


Lys Ala Leu Lys Thr Arg Phe Pro Glu Phe His Pro Asp Glu Leu Lys 
            180                 185                 190         


Asp Asn Ile Asn Val Arg Asn Met Phe Phe Ser Asn Arg Ile Tyr Pro 
        195                 200                 205             


Glu Ala Pro Pro Asp Asp Gly Glu Lys Ala Asp Tyr Arg Leu Val Pro 
    210                 215                 220                 


His Arg Asp Leu Ser Phe Ile Thr Leu Ala Asn Gln Val Pro Ala Asn 
225                 230                 235                 240 


Asn Gly Phe Lys Gly Leu Phe Ile Leu Thr Gly Asp Gly Glu Lys Ile 
                245                 250                 255     


Pro Val Pro Pro Ile Arg Asn Ser Tyr Leu Val Phe Ile Gly Gln Gly 
            260                 265                 270         


Leu Ser Tyr Leu Thr Asn Lys Tyr Leu Pro Ala Ala Leu His Gly Val 
        275                 280                 285             


Asp Phe Pro Asp Asn Thr Asn Phe Glu Gly Ser Glu Arg Ala Ser Leu 
    290                 295                 300                 


Ile Ser Phe Tyr Glu Pro Asn Asp Tyr Met Met Pro Ser Lys Asn Ile 
305                 310                 315                 320 


Asn Pro Leu Pro Glu Glu Ile Phe Glu Lys Ser Cys Thr Phe Tyr Asp 
                325                 330                 335     


Asp Val Gly Val Gly Arg Ala Gly Thr Thr Tyr Asn Tyr Val Arg Tyr 
            340                 345                 350         


Lys Phe His Glu Gly Tyr Tyr Leu 
        355                 360 


<210>  2
<211>  351
<212>  PRT
<213>  Palmaria palmata

<400>  2

Met Pro Val Tyr Asn Gly Thr Ser Gln Ala Phe Asn Phe Ala Pro Leu 
1               5                   10                  15      


His Pro Asp Ser Leu Asn Trp Cys Pro Lys Ser Ser Leu Pro Pro Glu 
            20                  25                  30          


Ile Pro Val Val Asp Leu Ser Lys Leu Asn Ser Glu Ala Glu Leu Ala 
        35                  40                  45              


Gln Phe Leu Val Asp Ile Arg Lys Ser Gly Leu Phe Tyr Val Val Asn 
    50                  55                  60                  


His Gly Val Pro Glu Glu Leu Ser Ile Gly Cys Tyr Asn Arg Phe Arg 
65                  70                  75                  80  


Gln Phe Cys Asn Ile Pro Glu Asp Gln Arg Ala Glu Tyr Ser Thr Asp 
                85                  90                  95      


His His Phe Val Asn Gly Gly Tyr Met Pro Tyr Lys Ser Ser Ser Ile 
            100                 105                 110         


Gly Lys Ala Asn Lys Gly Lys Ser Gln Lys Asp Phe Val Val Lys Tyr 
        115                 120                 125             


Phe Trp Arg Gly Pro Arg Val Glu Asn Arg Ser Pro Asp Ala Asp Phe 
    130                 135                 140                 


Lys Ser Tyr His Asp Glu Tyr His Arg Arg Thr Ala Asp Ile Ala Asn 
145                 150                 155                 160 


Ser Val Ile Thr Lys Ile Leu Gln Ala Leu Thr Thr Arg Phe Pro Asp 
                165                 170                 175     


Phe Asp Pro Ala Glu Tyr Lys Asp Asn Ile Asn Ser His His Met Phe 
            180                 185                 190         


Phe Ser Asn Arg Leu Tyr Pro Asp Asn Glu Pro Glu Lys Gly Glu Asn 
        195                 200                 205             


Val Glu Tyr Arg Leu Val Pro His Arg Asp Leu Ser Phe Val Thr Leu 
    210                 215                 220                 


Ala His Gln Ile Pro Ala Asp Asn Gly Tyr Gln Gly Leu Phe Val Phe 
225                 230                 235                 240 


Thr Gly Asp Gly Lys Lys Val Cys Val Pro Pro Ile Arg Asn Ser Tyr 
                245                 250                 255     


Leu Val Phe Met Gly Gln Ala Met Ser Tyr Leu Thr Asn Lys Tyr Leu 
            260                 265                 270         


Pro Ala Gly Leu His Gly Val Asp Phe Pro Glu Lys Asn Cys Phe Glu 
        275                 280                 285             


Gly Ser Glu Arg Ser Ser Leu Ile Ser Phe Tyr Glu Pro His Asp His 
    290                 295                 300                 


Met Met Pro Ser Lys Ala Leu Thr Pro Lys Asp Asp Glu Ile Phe Asp 
305                 310                 315                 320 


Arg Gly Cys Ser Phe Phe Asp Asp Ile Gly Val Asp Lys Thr Gly Thr 
                325                 330                 335     


Thr Tyr Met Tyr Val Lys Asn Lys Phe His Glu Gly Tyr Tyr Leu 
            340                 345                 350     


<210>  3
<211>  358
<212>  PRT
<213>  Palmaria hecatensis

<400>  3

Met Pro Val Tyr Asn Gly Thr Pro Gln Ala Tyr Asn Gly Thr Ser Gln 
1               5                   10                  15      


Ala Phe Asn Phe Ala Pro Leu Asp Ala Asp Ser Leu Thr Trp Cys Pro 
            20                  25                  30          


Glu Ser Ser Leu Pro Pro Glu Ile Pro Ala Ile Asp Leu Ser Lys Val 
        35                  40                  45              


Asn Ser Lys Ser Glu Leu Ala Glu Phe Leu Val Asn Ile Arg Lys Ser 
    50                  55                  60                  


Gly Leu Phe Tyr Val Val Asn His Gly Val Pro Glu Glu Leu Ser Met 
65                  70                  75                  80  


Gly Cys Tyr Asn His Phe Arg Glu Phe Cys Asn Ile Pro Glu Glu Glu 
                85                  90                  95      


Arg Ala Glu Tyr Ser Thr Asp His His Phe Val His Gly Gly Tyr Met 
            100                 105                 110         


Pro Tyr Lys Ser Ser Ser Ile Gly Lys Ala Asn Lys Gly Lys Asp Gln 
        115                 120                 125             


Lys Asp Phe Val Val Lys Tyr Phe Trp Arg Gly Pro Leu Val Glu Asn 
    130                 135                 140                 


Arg Ser Pro Ser Thr Gly Phe Lys Arg Tyr His Asp Glu Tyr His Arg 
145                 150                 155                 160 


Arg Thr Ser Asp Ile Ala Asn Ser Val Ile Ala Lys Ile Met Gln Ala 
                165                 170                 175     


Leu Thr Thr Arg Phe Pro Asp Phe Asp Pro Asp Glu Tyr Lys Lys Asn 
            180                 185                 190         


Ile Asn Ser His His Met Phe Phe Ser Asn Arg Leu Tyr Pro Asp Asn 
        195                 200                 205             


Glu Pro Glu Lys Gly Glu Asn Ala Glu Tyr Arg Leu Val Pro His Arg 
    210                 215                 220                 


Asp Leu Ser Phe Val Thr Leu Ala His Gln Ile Pro Ala Asp Asn Gly 
225                 230                 235                 240 


Tyr Gln Gly Leu Phe Val Leu Thr Gly Asp Gly Lys Lys Val Cys Val 
                245                 250                 255     


Pro Pro Ile Arg Asn Ser Tyr Leu Val Phe Met Gly Gln Ala Met Ser 
            260                 265                 270         


Tyr Leu Thr Asn Lys Tyr Leu Pro Ala Gly Leu His Gly Val Asp Phe 
        275                 280                 285             


Pro Glu Lys Asn Cys Phe Glu Gly Ser Glu Arg Ser Ser Leu Ile Ser 
    290                 295                 300                 


Phe Tyr Glu Pro His Asp His Met Met Pro Ser Lys Ala Leu Thr Pro 
305                 310                 315                 320 


Lys Asp Asp Glu Ile Phe Asp Arg Gly Cys Ser Phe Phe Asp Asp Ile 
                325                 330                 335     


Gly Val Asp Lys Ser Gly Thr Ala Tyr Met His Val Lys Asn Lys Phe 
            340                 345                 350         


His Glu Gly Tyr Tyr Leu 
        355             


<210>  4
<211>  351
<212>  PRT
<213>  Rhodophysema elegans

<400>  4

Met Ala Val Tyr Asn Gly Val Ser Gln Ala Phe Asp Phe Ala Pro Leu 
1               5                   10                  15      


Asp Ala Asp Ser Leu Asn Trp Cys Pro Gln Ser Ser Leu Pro Pro Glu 
            20                  25                  30          


Ile Pro Ala Ile Asp Leu Gly Lys Val Asn Thr Arg Ala Glu Leu Ala 
        35                  40                  45              


Gln Phe Leu Ile Asp Ile Arg Arg Ser Gly Leu Phe Tyr Val Val Asn 
    50                  55                  60                  


His Gly Val Pro Glu Glu Leu Ser Ile Gly Cys Tyr Asn Leu Phe Arg 
65                  70                  75                  80  


Arg Phe Cys Asn Ile Pro Glu Glu Glu Arg Ala Lys Tyr Ser Thr Asp 
                85                  90                  95      


His His Phe Val Asn Gly Gly Tyr Met Pro Tyr Lys Ser Ser Ser Ile 
            100                 105                 110         


Gly Lys Ala Asn Met Gly Lys Asp Gln Lys Asp Phe Val Val Lys Tyr 
        115                 120                 125             


Phe Trp Arg Gly Pro Arg Val Glu Asn Arg Thr Pro Thr Ala Glu Phe 
    130                 135                 140                 


Lys Lys Tyr His Asp Glu Tyr His Arg Arg Thr Ser Gly Val Ala Asp 
145                 150                 155                 160 


Thr Val Ile Glu Lys Ile Met Gln Ala Leu Ala Thr Arg Phe Pro Asp 
                165                 170                 175     


Phe Asp Pro Asp Glu Tyr Lys Glu Asn Thr Asn Ser His His Met Phe 
            180                 185                 190         


Phe Ser Asn Arg Leu Tyr Pro Glu Asn Glu Pro Glu Lys Gly Glu Asn 
        195                 200                 205             


Val Glu Tyr Arg Leu Val Pro His Arg Asp Leu Ser Leu Val Thr Leu 
    210                 215                 220                 


Ala His Gln Ile Pro Ala Asp Asn Gly Tyr Gln Gly Leu Phe Val Leu 
225                 230                 235                 240 


Thr Gly Asp Gly Lys Lys Val Pro Val Pro Pro Ile Arg Asn Ser Tyr 
                245                 250                 255     


Leu Val Phe Leu Gly Gln Ala Leu Ser Tyr Leu Thr Asn Lys Tyr Leu 
            260                 265                 270         


Pro Ala Gly Leu His Gly Val Asp Phe Pro Glu Lys Asn Ser Phe Glu 
        275                 280                 285             


Gly Ser Glu Arg Ser Ser Leu Ile Ser Phe Tyr Glu Pro His Asp Arg 
    290                 295                 300                 


Met Met Pro Ser Lys Ala Leu Thr Pro Lys Glu Asp Glu Val Phe Asp 
305                 310                 315                 320 


Arg Ser Cys Ser Phe Phe Asp Asp Ile Gly Val Asp Thr Ser Gly Thr 
                325                 330                 335     


Thr Tyr Met Tyr Val Lys Asn Lys Phe His Glu Gly Tyr Tyr Leu 
            340                 345                 350     


<210>  5
<211>  350
<212>  PRT
<213>  Grateloupia filicina

<400>  5

Met Thr Ser Phe Asp Phe Val Ala Lys Thr Phe Asp Phe Ala Pro Val 
1               5                   10                  15      


Lys Ala Asp Glu Leu Lys Trp Tyr Pro Arg Ser Ala Leu Pro Pro Glu 
            20                  25                  30          


Ile Pro Val Ile Asp Leu Asn Asn Val Asn Thr Glu Glu Glu Leu Ala 
        35                  40                  45              


Gln Phe Leu Val Asp Ile Arg Lys Ser Gly Leu Phe Tyr Val Val Asn 
    50                  55                  60                  


His Asp Ile Pro Glu Glu Ile Ser Ile Gln Thr Tyr Asn Glu Phe Arg 
65                  70                  75                  80  


Glu Phe Cys Lys Leu Pro Glu Glu Ala Arg Gln Lys Tyr Asn Thr Asp 
                85                  90                  95      


Arg Cys Phe Phe Asn Gly Gly Tyr Val Pro Phe Lys Ala Thr Ser Ile 
            100                 105                 110         


Asn Gly Gly Asn Lys Asn Lys Gln Gln Arg Asp Phe Val Val Lys Phe 
        115                 120                 125             


Phe Trp Arg Gly Pro His Val Val Asn Arg Ser Pro Asn Glu Arg Phe 
    130                 135                 140                 


Ala Lys Trp His His Gln Tyr His Thr Arg Thr Ala Glu Leu Gly Glu 
145                 150                 155                 160 


Lys Val Met Thr Thr Ile Ala Lys Ala Leu Lys Thr Arg Phe Pro Asp 
                165                 170                 175     


Phe Asp Pro Ala Glu Leu Glu Asp Asn Val Asn Pro His Asn Met Ile 
            180                 185                 190         


Phe Ser Asn Arg Ile Tyr Pro Glu Phe Pro Pro Ser Glu Gly Glu Asp 
        195                 200                 205             


Ala Glu Tyr Arg Leu Thr Pro His Arg Asp Ile Ser Tyr Ile Thr Leu 
    210                 215                 220                 


Val Asn Gln Thr Pro Ala Asn Asn Gly Phe Lys Ala Leu Phe Ile Val 
225                 230                 235                 240 


Thr Gly Asp Gly Glu Arg Val Tyr Val Pro Pro Ile Arg Asn Ser Tyr 
                245                 250                 255     


Leu Val Phe Ile Gly Gln Ser Leu Ser Tyr Leu Thr Asn Lys Tyr Leu 
            260                 265                 270         


Pro Ala Ala Leu His Gly Val Ala Phe Pro Asp Gly Asn Leu Glu Gly 
        275                 280                 285             


Cys Glu Arg Ala Ser Leu Val Ser Phe Tyr Glu Pro Tyr Asp Arg Met 
    290                 295                 300                 


Val Pro Ser Lys Asn Ile Lys Pro Thr Ala Glu Glu Ile Ala Pro Lys 
305                 310                 315                 320 


Ser Cys Ser Phe Tyr Asp Ser Ile Gly Cys Asp Lys Thr Gly Thr Thr 
                325                 330                 335     


Phe Thr Asp Val Arg Ala Lys Phe His Ser Gly Tyr Tyr Val 
            340                 345                 350 


<210>  6
<211>  1083
<212>  DNA
<213>  Digenea simplex

<400>  6
atgacagtaa gtaagtacaa cggtgttgcg agtacgttca acggtgttgc aaggagattc       60

gactttgccc cattggaggc agataaattg aattggtatc ccaggtcagc tcttcctcca      120

gaaatccctg ctatcgacct gaataaggtc aatactgaag aagaactggc tcaattcctg      180

gtcgatattc gcaaatctgg gctcttttat attgttgatc atggcattcc agaggagatc      240

tctataggat gttacaatgc attccgtgag ttttgcaacc ttcccgagga agcaagagag      300

aagtacaaca cagatgagtc ctttaaaagc ggtggctatg ttcctttcaa aggcacgtcg      360

attggtggag ggaacttgtt tgaacgacag aaggatttcg ttgtcaaatt cttttggaga      420

ggaccaagtg ttgtcaatag gtctcctaat gatcgctttg ccgaattcca tgatgaacat      480

catcgaaaga cagctgagtt ggccgaaaaa atcatcacta ccattttgaa agccctgaag      540

acacgctttc cagaattcca tcctgacgag ctaaaggata atatcaatgt tcgaaacatg      600

tttttcagta atcgaatcta tccagaggct ccgccagatg atggagaaaa agctgactac      660

cgacttgttc ctcatcgaga tctcagtttt atcactcttg caaatcaagt tccggctaac      720

aatggattca agggtctttt tatactgaca ggtgatggag aaaaaattcc tgttcctcca      780

atccggaaca gctacttggt cttcatcggt caaggcctct catatctcac gaataagtat      840

cttcctgcag cgcttcatgg tgtggacttt ccagacaata caaattttga aggaagtgaa      900

agagcctctc tgatcagctt ctacgagcca aacgattaca tgatgccatc caagaacatt      960

aaccctttac ctgaggagat atttgagaaa agctgtacgt tttacgatga tgtcggagta     1020

gggagggctg gtacaacata taattacgtg aggtacaaat ttcatgaagg atactacctt     1080

taa                                                                   1083


<210>  7
<211>  1056
<212>  DNA
<213>  Rhodophysema elegans

<400>  7
atggcggtgt acaatggcgt ctcgcaggcc ttcgacttcg cgccgctcga cgccgacagc       60

ctcaactggt gcccccagtc gtccctgccg cccgagatcc ccgccatcga cctcggcaaa      120

gtgaacacca gggccgagct cgcccagttc ctgatcgaca tccgcaggtc cggcctcttc      180

tacgtcgtca accacggcgt gccggaagag ctctcgatcg gctgctacaa cctctttcgc      240

cgcttctgca acatccccga ggaggagcgc gccaagtaca gcaccgacca tcatttcgtc      300

aacggcggct acatgccata caagagctcc tccatcggca aggcgaacat gggcaaggac      360

cagaaggact ttgtcgtcaa gtacttctgg agggggcccc gcgtggagaa caggacgccc      420

accgccgagt ttaagaagta tcacgatgag taccatcgca ggacttcggg cgtcgcagac      480

acggtcatag agaagattat gcaggcgctg gcgacgcgct ttccggactt cgaccccgac      540

gagtacaagg agaacacgaa cagccatcac atgtttttca gcaacaggct ctaccccgaa      600

aacgagccgg agaaggggga gaacgtcgag taccgccttg ttccgcatcg cgacctcagt      660

ttggtgacgc tcgcgcacca gatccccgca gacaatggct accagggcct gttcgttctt      720

accggcgacg ggaagaaggt gcctgtgccg cctatccgca acagctatct cgtcttcctg      780

gggcaggcgt tgtcttatct caccaacaag tatctgcctg ctggattgca tggcgtggac      840

tttccggaga agaactcctt tgaggggagc gagcggtcgt cacttatttc attctacgag      900

ccgcacgacc gcatgatgcc gtcgaaggcg ctcacgccaa aagaggatga agtttttgat      960

agaagctgct cctttttcga tgatattggt gttgatacga gtggcacgac gtatatgtac     1020

gtgaaaaata agttccacga gggctattat ctatag                               1056


<210>  8
<211>  1056
<212>  DNA
<213>  Palmaria hecatensis

<400>  8
atggcggtgt acaatggcgt ctcgcaggcc ttcgacttcg cgccgctcga cgccgacagc       60

ctcaactggt gcccccagtc gtccctgccg cccgagatcc ccgccatcga cctcggcaaa      120

gtgaacacca gggccgagct cgcccagttc ctgatcgaca tccgcaggtc cggcctcttc      180

tacgtcgtca accacggcgt gccggaagag ctctcgatcg gctgctacaa cctctttcgc      240

cgcttctgca acatccccga ggaggagcgc gccaagtaca gcaccgacca tcatttcgtc      300

aacggcggct acatgccata caagagctcc tccatcggca aggcgaacat gggcaaggac      360

cagaaggact ttgtcgtcaa gtacttctgg agggggcccc gcgtggagaa caggacgccc      420

accgccgagt ttaagaagta tcacgatgag taccatcgca ggacttcggg cgtcgcagac      480

acggtcatag agaagattat gcaggcgctg gcgacgcgct ttccggactt cgaccccgac      540

gagtacaagg agaacacgaa cagccatcac atgtttttca gcaacaggct ctaccccgaa      600

aacgagccgg agaaggggga gaacgtcgag taccgccttg ttccgcatcg cgacctcagt      660

ttggtgacgc tcgcgcacca gatccccgca gacaatggct accagggcct gttcgttctt      720

accggcgacg ggaagaaggt gcctgtgccg cctatccgca acagctatct cgtcttcctg      780

gggcaggcgt tgtcttatct caccaacaag tatctgcctg ctggattgca tggcgtggac      840

tttccggaga agaactcctt tgaggggagc gagcggtcgt cacttatttc attctacgag      900

ccgcacgacc gcatgatgcc gtcgaaggcg ctcacgccaa aagaggatga agtttttgat      960

agaagctgct cctttttcga tgatattggt gttgatacga gtggcacgac gtatatgtac     1020

gtgaaaaata agttccacga gggctattat ctatag                               1056


<210>  9
<211>  1056
<212>  DNA
<213>  Palmaria palmata

<400>  9
atgcccgtgt acaacggcac ctcccaggcc ttcaacttcg cgcccctcca ccccgacagc       60

ctcaactggt gccccaagtc gtccctgccc cccgagatcc ccgtagtcga ccttagcaaa      120

ctcaactctg aggccgagct cgcccagttt ctggtcgaca tccgcaagtc cggcctcttc      180

tacgttgtca accacggcgt gccggaggag ctctccatcg gctgctacaa ccgcttccgc      240

cagttttgca acatccccga ggaccagcgc gccgagtaca gcaccgacca ccattttgta      300

aacggcggct acatgcccta caaaagcagt tccattggca aggcgaacaa gggcaagagt      360

cagaaggact ttgtcgtcaa gtacttctgg agggggcccc gtgttgagaa caggtcgccc      420

gacgccgact tcaagagcta tcacgacgag taccaccgga ggaccgccga catcgcgaac      480

agcgtcatca ccaaaatcct gcaggcgttg acaacccgct tcccagactt tgaccccgct      540

gagtacaagg acaacataaa cagccaccac atgtttttca gcaatcgcct gtatcccgac      600

aacgagccgg agaaaggaga gaacgtggag taccgcctgg ttccgcatcg agatctcagt      660

ttcgtcaccc tcgcccacca gatccccgca gacaacggct accagggcct gttcgttttc      720

accggcgacg ggaagaaggt ctgtgtgccg cccatccgca acagctacct cgtcttcatg      780

gggcaggcga tgtcctatct caccaacaag tacctgcctg ccggcctgca tggtgtcgac      840

tttccggaga agaactgttt tgagggcagc gagcggtcgt cccttatttc gttttacgag      900

ccgcacgacc acatgatgcc ttcgaaggcg ctgaccccga aagatgatga aatttttgat      960

agaggctgct cctttttcga tgatattggt gtcgataaga ctggcacgac ttatatgtac     1020

gtcaaaaata agttccacga gggatattat ctatag                               1056


<210>  10
<211>  1053
<212>  DNA
<213>  Grateloupia filicina

<400>  10
atgacttcgt ttgatttcgt tgcgaagacc tttgactttg ctcccgtgaa agcagatgaa       60

ctgaaatggt accccaggtc tgctctccct ccagaaatcc ctgtcatcga tctgaacaac      120

gtcaacactg aagaagagct ggctcaattc ttggttgata ttcgcaaatc tggactcttc      180

tatgtggtca accatgacat tccagaagag atatccatcc aaacttacaa cgaatttcgt      240

gagttttgca agctccctga ggaggccaga cagaagtata acactgatag atgcttcttt      300

aatggcggtt acgttccttt caaagccact tcaattaatg gaggcaacaa gaacaaacag      360

cagagagatt ttgtcgtaaa attcttctgg agagggccgc atgtcgtcaa caggagtccg      420

aacgagcgct tcgcaaaatg gcaccaccaa tatcacacaa gaactgctga actaggtgaa      480

aaggtcatga ctaccatcgc gaaagctttg aagacacgct ttccggattt tgaccctgct      540

gagttggaag acaacgtcaa cccgcacaac atgattttca gtaatcgaat ctacccagag      600

tttccaccca gcgaaggaga ggatgccgaa taccgactta ctcctcatag ggatatcagt      660

tatatcaccc tcgtgaatca aactccggca aacaatggct ttaaggctct tttcatagta      720

actggtgatg gggagagagt ctatgttcct cccatccgca acagttactt ggtattcatt      780

ggacagagcc tttcatatct caccaacaag tatcttcctg ccgccctgca tggggtggcc      840

tttccagacg gaaatttaga aggatgtgag agggcatctt tggtttcctt ctacgagcct      900

tacgatcgta tggtgccttc aaaaaacatc aagcccacag cagaggagat tgctccgaaa      960

agctgttcat tttacgattc tatcggatgt gataagactg gcacgacatt tacggacgtg     1020

agggcgaaat ttcattccgg atactatgtt tga                                  1053


<210>  11
<211>  439
<212>  PRT
<213>  Digenea simplex

<400>  11

Met Ser Ile Thr Thr Met Lys Gly Val Thr Ser Glu Ser Pro Ala Glu 
1               5                   10                  15      


Ala Leu Ser Arg Phe Gln Thr Thr Gly Leu Thr Leu Asn Asn Pro Lys 
            20                  25                  30          


Asp Leu Tyr Trp Met Thr Glu Phe Leu Lys Glu Glu Phe Tyr Asp Lys 
        35                  40                  45              


Gly Asn Tyr Tyr Tyr Pro Ile Lys Thr Val Cys Asp Gly Glu Leu Ile 
    50                  55                  60                  


Glu Thr Glu Leu Phe Cys Pro Phe Glu Pro Lys Leu Ser Pro His Tyr 
65                  70                  75                  80  


Ile Gln Leu Tyr Asn Ser Arg Asp Glu Arg Ser Asn Leu Tyr Ala Val 
                85                  90                  95      


Pro Pro Lys Lys Thr Asp Met Lys Lys Tyr Asn Arg Ile Asn Cys Glu 
            100                 105                 110         


Lys Met Gly Ser Leu Met Ala Pro Asn Ser Asn Tyr Asp Asp Thr Glu 
        115                 120                 125             


Met Val Ser Leu Phe Tyr Ser Met Met Tyr Tyr Leu Asn Asp Gln Thr 
    130                 135                 140                 


Ala His Leu Lys Leu Pro Glu Glu Asp Ile Gln Pro Glu Leu Val Asp 
145                 150                 155                 160 


Glu Leu Asn Asp His Val Leu Gln Tyr Leu Ser Val Phe Leu Ser Ile 
                165                 170                 175     


Phe Lys Pro Arg Glu Pro Gln Asp Leu Glu Arg Ile Trp Asn Phe Leu 
            180                 185                 190         


Asp Phe Tyr Gln Pro Tyr Phe Lys Lys Val Asp Gly Lys Ile Ile Leu 
        195                 200                 205             


His Glu Lys Tyr Gln Gly Arg Thr Pro Pro Gln Ile Gly Leu Ile Lys 
    210                 215                 220                 


Lys Ile Thr Gly Tyr Val Leu Glu Arg Phe Ala Pro Lys Lys Asn Ile 
225                 230                 235                 240 


Thr Gln Val Ile Tyr Glu Val Ile Arg Tyr Ile Lys Gly Ile Lys Gln 
                245                 250                 255     


Glu Ile Lys Ile Arg Gly Asp Lys Ser Phe Thr Leu Ser Leu Lys Glu 
            260                 265                 270         


Tyr Asp Glu Phe Arg Asp Gln Val Thr Ser Ser Pro Met Ala His Ser 
        275                 280                 285             


Ile Thr Asp Leu Thr Tyr Asp Asp Phe Ser Tyr Lys Ala Tyr Met Asn 
    290                 295                 300                 


Pro Leu Phe Ile Lys Leu Glu Asp Leu Thr Ser Glu Ile Ile Thr Tyr 
305                 310                 315                 320 


Phe Asn Asp Val Cys Thr Cys Asp Arg Glu Arg Leu Asp Asp Asp Pro 
                325                 330                 335     


Phe Asn Ser Val Phe Ile Leu Arg Asp Leu His Ser Leu Asn Tyr Val 
            340                 345                 350         


Lys Ser Cys Asp Leu Val Val Lys His Ala His Asp Lys Leu Ser Lys 
        355                 360                 365             


Phe Leu Glu Ile Lys Gln Thr Leu Leu Lys Glu Ser Thr Asn Glu Asn 
    370                 375                 380                 


Glu Lys Lys Ala Ile Ala Gln Met Ile Lys Thr Arg Glu Asp Ser Leu 
385                 390                 395                 400 


Ile Gly Tyr Thr Ile His Glu Ile Cys Cys Val Thr Asn Gly Tyr Ala 
                405                 410                 415     


Arg Asp His Lys Pro Leu Met Lys Asp Tyr Leu Glu Lys Asn Ile Phe 
            420                 425                 430         


Lys Lys Leu Lys Ala Thr Asn 
        435                 


<210>  12
<211>  488
<212>  PRT
<213>  Palmaria palmata

<400>  12

Met Leu Pro Pro Ala Phe Leu Pro Pro Ala Val His Ser Leu Phe Arg 
1               5                   10                  15      


Gly Gly Leu Leu Gln Arg Pro Glu His Val Gly Pro Thr Pro Thr Ala 
            20                  25                  30          


Thr Pro Ser Ala Ala Ser Ile Arg Ala His Arg Ala Pro Thr Thr Leu 
        35                  40                  45              


Val Met Val Ala His Gly Arg Arg Arg Leu Glu Arg Pro Thr Ala Ala 
    50                  55                  60                  


Leu Pro Thr Gly Ala Arg Arg Thr Gly Leu Thr Leu Thr Asp Pro Ala 
65                  70                  75                  80  


Asp Leu His Ser Met Val Ala His Leu Lys Lys Glu Asn Phe Asp Lys 
                85                  90                  95      


Gly Asn Cys Asn Tyr Pro Ile Lys Thr Val Cys Asp Gly Glu Leu Ile 
            100                 105                 110         


Asp Val Gln Phe Ala Phe Pro Phe Glu Pro Lys Leu Ser Pro His Tyr 
        115                 120                 125             


Ala Ala Leu Tyr Asn Ser Arg Asp Glu Arg Ser Gln Leu Tyr Ala Val 
    130                 135                 140                 


Pro Pro Ser Thr Thr Asp Met Lys Lys Tyr Asn Arg Ile Asn Cys Glu 
145                 150                 155                 160 


Lys Met Gly Ala Leu Leu Ala Pro Asn Ser Ala Tyr Gly Asp Thr Glu 
                165                 170                 175     


Ile Val Ser Leu Phe Tyr Ser Met Met Tyr Tyr Leu Asn Asp Gln Thr 
            180                 185                 190         


Ala His Phe Lys Leu Pro Glu Glu Glu Ile Gln Tyr Glu Leu Val Asp 
        195                 200                 205             


Glu Leu Asn Asp Asn Val Leu Gln Tyr Leu Ser Ile Phe Leu Gly Val 
    210                 215                 220                 


Phe Lys Pro Arg Asp Ala Ala Asp Leu Glu Arg Ile Trp Asp Phe Leu 
225                 230                 235                 240 


Glu Phe Tyr Gln Pro Tyr Phe His Lys Val Asp Gly Arg Ile Glu Leu 
                245                 250                 255     


Asp Ala Lys Tyr Ser Gly Gln Thr Pro Pro Gln Val Ala Leu Val Ser 
            260                 265                 270         


Lys Ile Ala Gly Tyr Ala Ala Asp Arg Phe Gly Ala Ser Lys Asn Ile 
        275                 280                 285             


Thr Gln Ile Ile Tyr Glu Val Ile Arg Tyr Val Lys Gly Ile Lys Glu 
    290                 295                 300                 


Glu Ile Lys Ile Arg Cys Asp Lys Gly Phe Ser Leu Thr Leu Ser Glu 
305                 310                 315                 320 


Tyr Asp Ala Phe Arg Asp Asn Val Thr Ser Ser Pro Met Ala His Ser 
                325                 330                 335     


Val Thr Asp Leu Thr His Asp Ala Phe Ser Tyr Glu Ala Tyr Thr Asn 
            340                 345                 350         


Pro Val Phe Asn Glu Leu Glu Asn Leu Thr Ser Gln Val Ile Thr Tyr 
        355                 360                 365             


Val Asn Asp Val Cys Thr Cys Asp Arg Glu Arg Leu Asp Asp Asp Pro 
    370                 375                 380                 


Phe Asn Ser Val Phe Ile Leu Lys Asn Arg Asp Gly Leu Asn Phe Ala 
385                 390                 395                 400 


Glu Ala Cys Asp Arg Val Val Gly Glu Val Val Lys Lys Thr Ala Arg 
                405                 410                 415     


Phe Leu Glu Thr Lys Glu Arg Leu Leu Ala Glu Ala Ala Asp Glu Asp 
            420                 425                 430         


Gly Arg Ala Ala Met Ala Gln Met Ile Lys Thr Arg Glu Asp Ser Ile 
        435                 440                 445             


Ile Gly Tyr Met Leu His Glu Val Cys Cys Val Thr Asp Gly Tyr Ala 
    450                 455                 460                 


Arg Asp His Lys Pro Leu Met Lys Asp Tyr Leu Glu Lys Thr Met Phe 
465                 470                 475                 480 


Gly Glu Val Ala Ser Gly Ala Met 
                485             


<210>  13
<211>  485
<212>  PRT
<213>  Palmaria hecatensis

<400>  13

Met Pro Pro Pro Ala Phe Leu Pro Pro Ala Val Arg Ser Leu Phe Arg 
1               5                   10                  15      


Gly Ala Pro Leu Gln Arg Leu Gln His Val Gly Pro Ile Gln Ser Ala 
            20                  25                  30          


Thr Pro Ser Ala Ala Ser Ile Arg Ala Arg Arg Ala Ala Arg Thr Leu 
        35                  40                  45              


Val Met Val Asp Ala Gly Pro Glu Arg Pro Thr Ala Ala Pro Pro Thr 
    50                  55                  60                  


Gly Ala Arg Arg Thr Asp Leu Thr Leu Thr Asp Pro Ala Asp Leu Ala 
65                  70                  75                  80  


Leu Met Val Ala His Leu Lys Arg Glu His Phe Asp Lys Gly Tyr Cys 
                85                  90                  95      


Thr Tyr Pro Ile Lys Thr Val Cys Asp Gly Glu Leu Ile Asp Val Gln 
            100                 105                 110         


Phe Ser Phe Pro Phe Glu Pro Lys Leu Ser Pro His Tyr Ala Ala Leu 
        115                 120                 125             


Tyr Asn Ser Arg Asp Glu Arg Ser Gln Leu Tyr Ala Val Ser Pro Asn 
    130                 135                 140                 


Thr Thr Asp Met Lys Lys Tyr Asn Arg Ile Asn Cys Glu Lys Met Gly 
145                 150                 155                 160 


Ala Leu Leu Ala Pro Asn Ser Ala Tyr Gly Asp Thr Glu Met Val Ser 
                165                 170                 175     


Leu Phe Tyr Ser Met Met Tyr Tyr Leu Asn Asp Gln Thr Ala His Phe 
            180                 185                 190         


Lys Leu Pro Glu Glu Glu Ile Gln Tyr Glu Leu Val Asp Glu Leu Asn 
        195                 200                 205             


Asp Asn Val Leu Gln Tyr Leu Ser Ile Phe Leu Gly Val Phe Glu Pro 
    210                 215                 220                 


Arg Asp Ala Ala Asp Leu Glu Arg Ile Trp Asp Phe Leu Glu Phe Tyr 
225                 230                 235                 240 


Gln Pro Tyr Phe Asn Lys Val Gly Gly Lys Ile Val Leu Asp Ala Lys 
                245                 250                 255     


Tyr Ser Gly Gln Thr Pro Pro Gln Val Ala Leu Val Thr Lys Ile Ala 
            260                 265                 270         


Gly Tyr Ala Ala Gly Arg Phe Gly Ala Thr Lys Asn Ile Thr Gln Ile 
        275                 280                 285             


Ile Tyr Glu Val Ile Arg Tyr Val Lys Gly Ile Lys Gln Glu Ile Lys 
    290                 295                 300                 


Ile Arg Cys Asp Lys Ser Phe Thr Leu Asn Leu Ala Glu Tyr Asp Ala 
305                 310                 315                 320 


Phe Arg Asp Gln Val Thr Ser Ser Pro Met Ala His Ser Val Thr Asp 
                325                 330                 335     


Leu Thr His Asp Ala Phe Ser Tyr Lys Ala Tyr Thr Asn Pro Val Phe 
            340                 345                 350         


Asn Asp Leu Glu Asn Leu Thr Ser Gln Ile Ile Thr Tyr Val Asn Asp 
        355                 360                 365             


Val Cys Thr Cys Asp Arg Glu Arg Leu Asp Asp Asp Pro Phe Asn Ser 
    370                 375                 380                 


Val Phe Ile Leu Lys Asn Arg Asp Gly Leu Asn Phe Ala Asp Ala Cys 
385                 390                 395                 400 


Asp Leu Val Val Gly Glu Val Val Lys Lys Thr Ala Lys Phe Leu Glu 
                405                 410                 415     


Thr Lys Asp Arg Leu Leu Ala Glu Ala Ala Asp Glu Glu Gly Arg Ala 
            420                 425                 430         


Ala Ile Ala Gln Lys Ile Lys Thr Arg Glu Asp Ser Ile Ile Gly Tyr 
        435                 440                 445             


Met Met His Glu Val Cys Cys Val Thr Asp Gly Tyr Ala Arg Asp His 
    450                 455                 460                 


Lys Pro Leu Met Lys Glu Tyr Leu Glu Lys Ala Met Phe Gly Glu Ala 
465                 470                 475                 480 


Ser Ser Gly Ala Leu 
                485 


<210>  14
<211>  479
<212>  PRT
<213>  Rhodophysema elegans

<400>  14

Met Ser Pro Ser Ala Phe Leu Pro Leu Ala Gly Pro Leu Ala Phe Arg 
1               5                   10                  15      


Arg Ala Ser Leu Gln Arg Leu Asn His Thr Arg Thr Leu Pro Pro Thr 
            20                  25                  30          


Val Ala Pro Ser Arg Ala Pro Met Thr Pro Phe Met Val Asp Thr Ser 
        35                  40                  45              


Arg Gly His Pro Ala Thr Ala Ala Pro Pro Met Gly Ala Arg Arg Ser 
    50                  55                  60                  


Leu Thr Leu Thr Asp Pro Ala Asp Leu Ala Leu Met Val Ser His Leu 
65                  70                  75                  80  


Lys Arg Glu His Phe Asp Lys Gly Asp Tyr Leu Tyr Pro Ile Lys Thr 
                85                  90                  95      


Val Cys Ala Gly Glu Asp Ile Asp Val Arg Phe Ala Ile Pro Phe Glu 
            100                 105                 110         


Pro Arg Leu Ser Ser His Tyr Ala Ala Leu Tyr Asn Ser Arg Asn Asp 
        115                 120                 125             


Arg Ala Lys Leu Tyr Ala Val Pro Pro Arg Thr Thr Asp Met Arg Lys 
    130                 135                 140                 


Tyr Asn Arg Ile Asn Cys Glu Lys Met Gly Ala Leu Leu Ala Pro Asn 
145                 150                 155                 160 


Ser Ala Tyr Gly Asp Thr Glu Ala Val Ser Leu Phe Tyr Ser Met Met 
                165                 170                 175     


Tyr Tyr Leu Asn Asp Gln Thr Ala Ile Cys Lys Leu Pro Glu Asp Glu 
            180                 185                 190         


Ile Glu Leu Arg Leu Val Asp Glu Leu Asn Asp Asn Val Leu Gln Tyr 
        195                 200                 205             


Leu Gly Ile Phe Leu Ser Val Phe Glu Pro Arg Asp Ala Ala Asp Leu 
    210                 215                 220                 


Glu Arg Ile Trp Asp Phe Leu Asp Phe Tyr Gln Pro Tyr Phe Arg Lys 
225                 230                 235                 240 


Ala Gly Arg Arg Ile Val Leu Asp Asp Lys Tyr Leu Gly Gln Thr Pro 
                245                 250                 255     


Pro Gln Val Ala Leu Val Thr Thr Ile Ala Asn Tyr Val Ala Glu Arg 
            260                 265                 270         


Phe Gly Ala Thr Lys Asn Ile Thr Gln Val Val Tyr Glu Val Ile Arg 
        275                 280                 285             


Tyr Val Lys Gly Ile Lys Gln Glu Val Lys Ile Arg Cys Asp Lys Gly 
    290                 295                 300                 


Phe Thr Leu Ser Leu Ala Glu Tyr Asp Asp Phe Arg Asp Gln Val Thr 
305                 310                 315                 320 


Ser Ser Pro Met Ala His Ser Val Thr Asp Leu Thr His Asp Ala Phe 
                325                 330                 335     


Ser Tyr Glu Ala Tyr Lys Asn Pro Val Phe Asn Ser Leu Glu Asn Leu 
            340                 345                 350         


Thr Ser Gln Val Ile Thr Tyr Ile Asn Asp Val Cys Thr Cys Asp Arg 
        355                 360                 365             


Glu Arg Leu Asp Lys Asp Pro Phe Asn Ser Val Phe Ile Leu Lys Asp 
    370                 375                 380                 


Arg Asp Gly Leu Asn Phe Ala Asp Ala Cys Asp Leu Val Val Ala Glu 
385                 390                 395                 400 


Ile Glu Lys Lys Met Ala Lys Phe Leu Glu Thr Lys Lys Gln Leu Leu 
                405                 410                 415     


Ser Glu Ala Ala Asp Glu Glu Arg Arg Thr Ala Met Ala Gln Met Ile 
            420                 425                 430         


Lys Thr Arg Glu Asp Ser Ile Ile Gly Tyr Met Met His Glu Val Cys 
        435                 440                 445             


Cys Val Thr Asp Gly Tyr Ala Arg Asp His Lys Pro Lys Met Lys Glu 
    450                 455                 460                 


Tyr Leu Glu Lys Ala Met Phe Gly Glu Val Ser Arg Glu Ala Met 
465                 470                 475                 


<210>  15
<211>  452
<212>  PRT
<213>  Grateloupia filicina

<400>  15

Met Asn Leu Ile Leu Arg Ser Asn Met Pro Ile Phe Pro Ser Cys Ala 
1               5                   10                  15      


Phe Leu Ser Ser Ser Thr Thr Thr Thr Phe Ile Gln Pro Leu Val Lys 
            20                  25                  30          


Arg Ile His Ser Val Cys Pro Asn Pro Val Arg His Glu Pro Val Ser 
        35                  40                  45              


Ala Asn Arg Arg Leu Val Met Arg Leu Ala Trp Asn Pro Thr Pro Thr 
    50                  55                  60                  


Gln Gln Leu Thr Thr Glu Ser Pro Thr Glu Ala Leu Ser Arg Leu Gln 
65                  70                  75                  80  


Thr Thr Gly Leu Thr Leu Thr Asp Pro Lys Asp Leu Tyr Trp Met Thr 
                85                  90                  95      


Asp Phe Leu Glu Gln Gln Phe Tyr Ser Lys Arg Asn Pro Asn Tyr Pro 
            100                 105                 110         


Met Lys Thr Ile Cys Asp Gly Glu Leu Ile Glu Thr Glu Phe His Cys 
        115                 120                 125             


Pro Tyr Gln Pro Lys Leu Ser Pro His Tyr Met Arg Leu Cys Asn Thr 
    130                 135                 140                 


Lys His Glu Arg Ser Leu Leu Tyr Ser Ile Pro Pro Asn Thr Thr Asp 
145                 150                 155                 160 


Met Asn Lys Tyr Asn Arg Ile Asn Cys Glu Lys Phe Ala Ser Leu Val 
                165                 170                 175     


Ala Pro Asn Ser Asn Tyr Glu Asp Thr Glu Ala Val Ala Leu Met Tyr 
            180                 185                 190         


Ser Met Met Tyr Tyr Leu Asn Asp Gln Thr Ala His Leu Lys Leu Pro 
        195                 200                 205             


Glu Asp Met Ile Gln Pro Gln Leu Ile Asp Glu Leu Asn Asp Asn Val 
    210                 215                 220                 


Leu Gln Tyr Leu Ala Val Phe Leu Ser Ile Phe Glu Pro Arg Asp Pro 
225                 230                 235                 240 


Glu Asp Leu Glu Arg Ile Trp Asp Phe Leu Asp Phe Tyr Gln Lys Tyr 
                245                 250                 255     


Phe Asn Lys Ile Asp Gly Lys Ile Val Leu Asp Glu Lys Tyr Lys Gly 
            260                 265                 270         


Pro Val Pro Pro Gln Ile Ala Leu Ile Asn Lys Ile Thr Gln Tyr Ile 
        275                 280                 285             


Ser Lys Arg Phe Ala Pro Thr Lys Asn Ile Thr Gln Phe Ile Tyr Glu 
    290                 295                 300                 


Val Ile Arg Tyr Ile Lys Gly Ile Lys Gln Glu Val Tyr Ile Arg Cys 
305                 310                 315                 320 


Asp Lys Ser Phe Thr Leu Ser Leu Lys Glu Tyr Asp Glu Phe Arg Asp 
                325                 330                 335     


Gln Val Thr Ser Ser Pro Met Ala His Ala Val Thr Asp Met Thr Tyr 
            340                 345                 350         


Asp Asn Phe Ser Tyr Lys Leu Tyr Leu Asn Pro Leu Phe Thr Glu Leu 
        355                 360                 365             


Glu Asn Leu Thr Ser Glu Leu Ile Thr Tyr Phe Asn Asp Val Cys Thr 
    370                 375                 380                 


Cys Asp Arg Glu Arg Leu Asp Asn Asp Pro Phe Asn Ser Val Phe Ile 
385                 390                 395                 400 


Leu Lys Asp Leu Tyr Gly Gly Thr Tyr Ala Gln Ser Cys Asp Leu Val 
                405                 410                 415     


Val Ser Glu Thr Arg Lys Lys Phe Ser Lys Phe Leu Glu Ile Lys Gln 
            420                 425                 430         


Ile Leu Leu Asp Gly Ala Ala Asp Glu Thr Glu Lys Gln Ala Ile Ala 
        435                 440                 445             


Gln Met Ile Lys 
    450         


<210>  16
<211>  1320
<212>  DNA
<213>  Digenea simplex

<400>  16
atgagtatta ccactatgaa aggagttaca tcagagagtc ctgccgaagc gctttcccgc       60

ttccaaacta ctggattgac gttgaacaac cccaaggacc tttactggat gacagaattt      120

ttgaaggaag aattttacga caagggaaac tattattatc ccatcaaaac ggtatgtgat      180

ggcgaactca tcgaaaccga gctcttctgt cccttcgaac caaagctcag tccacattac      240

attcaattat acaactctcg tgatgagcga tccaacttgt acgccgttcc gcccaagaaa      300

acagacatga aaaagtacaa tcgtataaat tgtgagaaaa tgggttcttt gatggcccct      360

aattccaatt atgacgacac agaaatggtt tctctcttct actccatgat gtactacctc      420

aatgatcaga ccgctcatct taagctccct gaagaagata ttcaacctga gcttgttgat      480

gaactcaacg accatgtctt acagtatcta agtgtgttcc ttagcatctt taaaccgcgt      540

gaacctcaag atttggagcg aatctggaat tttttggact tttaccagcc atatttcaag      600

aaagttgatg gcaagattat cttgcacgag aaatatcagg ggcgtactcc accacaaatc      660

ggtttgatca agaaaataac aggttatgta ttagagaggt ttgctccgaa aaagaatatc      720

actcaagtca tctacgaggt catcagatat atcaagggaa tcaagcaaga aattaagatt      780

cgaggtgata agagcttcac tctgtctctc aaagagtatg atgagttccg tgaccaagtt      840

acgtccagcc caatggctca ttcgattaca gatcttactt atgacgactt ctcttacaag      900

gcatacatga acccactctt catcaagctg gaagatctaa cctctgagat catcacgtac      960

ttcaacgacg tttgcacatg tgatcgcgag agactggacg atgatccttt caactctgtt     1020

ttcattctga gagatcttca cagtctcaac tatgtgaagt catgtgatct tgtcgttaag     1080

catgcacatg acaagctatc aaaattcttg gagatcaagc agactctttt gaaagaatct     1140

acaaacgaaa atgagaaaaa ggccattgcc cagatgatta agactcgtga agattccttg     1200

attggatata cgattcatga aatttgctgt gttacaaatg ggtatgctcg tgaccacaag     1260

cccttgatga aagattattt ggagaaaaat atctttaaga aactcaaggc gacaaattaa     1320


<210>  17
<211>  1467
<212>  DNA
<213>  Palmaria palmata

<400>  17
atgcttcctc ctgccttcct ccctccggcc gtgcactccc tcttccgcgg cggcctgctg       60

cagcgtccgg aacacgttgg tccaacccca actgcaacgc cttccgccgc ttcgatccgc      120

gcacaccgcg caccaacgac gctcgtcatg gtcgcgcacg gtcggcgccg tctcgaacgc      180

cccacagcgg cactaccaac cggcgcgcga cggaccggct tgacgctcac cgacccggcc      240

gacctgcatt ccatggtggc gcacctgaaa aaggagaact tcgacaaggg caactgcaac      300

tacccaatca agacggtgtg cgatggagaa ctcatcgacg tccagttcgc cttcccgttt      360

gaaccgaagc tgagcccgca ctacgccgcc ctgtacaatt cgcgtgacga gcgctcccag      420

ctgtacgctg tcccgcctag tactacagat atgaaaaaat acaaccgcat caactgcgag      480

aagatgggcg ccctgctcgc gccgaactct gcgtatggcg acacggagat agtgtcgctg      540

ttctattcga tgatgtatta tctcaatgac cagacggcgc acttcaagct accagaggaa      600

gagatccagt acgagctcgt ggacgagctc aacgacaatg tgctgcagta tctcagcata      660

tttctgggcg ttttcaagcc gcgcgatgct gcggatttgg agcgcatttg ggactttctc      720

gagttttacc agccctattt tcacaaggtc gacgggagga ttgagttaga tgccaagtat      780

agcgggcaga cgccgccgca ggtcgcgctt gtctcgaaga ttgcggggta cgccgcggat      840

cggttcggcg cgtcaaagaa catcacccag atcatctacg aggtcattcg atatgtcaag      900

ggcatcaagg aggagatcaa gatcaggtgc gacaagggct ttagcctcac cctctccgag      960

tacgacgcgt tccgggacaa tgtcacatcg agcccgatgg cgcactccgt aaccgacctg     1020

acgcacgatg cgttctccta cgaggcctac acgaaccccg tcttcaacga gctggaaaac     1080

ctgacctccc aagtcatcac ctacgtcaac gacgtgtgta cgtgcgaccg ggagcggctg     1140

gacgacgacc cgttcaattc ggtctttatt ctgaaaaatc gcgacggtct gaacttcgcc     1200

gaagcgtgcg atcgcgttgt cggcgaggtg gtgaagaaga cggcaaggtt cctggagacg     1260

aaggagcggc ttcttgcgga ggctgctgat gaagacggga gggcggccat ggcgcagatg     1320

atcaagacgc gcgaagactc gatcatcggg tacatgctgc acgaggtctg ctgcgtgacg     1380

gatgggtatg cgcgcgacca caagccgttg atgaaagact atctggagaa gacgatgttt     1440

ggtgaggtgg ccagcggagc aatgtag                                         1467


<210>  18
<211>  1458
<212>  DNA
<213>  Palmaria hecatensis

<400>  18
atgcctcctc ccgccttcct ccctccagcc gtgcgctccc tcttccgcgg cgccccgctg       60

cagcgtctgc aacacgtcgg tccaatccaa agtgcaacgc cctccgctgc ttcgatccgc      120

gcacgccgtg cagcaaggac gctcgtcatg gtcgacgcag gcccggagcg ccccacagca      180

gcaccaccaa ccggcgcgcg acggaccgac ttgacgctaa cggacccggc agatctggcg      240

ctcatggtcg cccatctgaa aagggagcac ttcgacaagg ggtactgcac ctacccgata      300

aagacggtgt gcgatggaga actcatcgac gtccagttct ccttcccgtt cgagccgaag      360

ctgagcccgc actacgcggc cctgtacaat tcgcgtgacg agcgctcgca gctgtacgct      420

gtctcgccaa atactacgga tatgaagaag tacaaccgca tcaactgcga gaagatgggc      480

gcgctgcttg ccccgaactc tgcatatggc gacacggaga tggtttcgct gttctactcg      540

atgatgtatt atctcaatga ccagacggcg cacttcaagc tgcccgagga ggagatccag      600

tacgagcttg tggacgagct caacgacaat gtgctgcagt atctcagcat ttttctgggc      660

gtgttcgagc cgcgcgatgc tgcggacttg gagcgtattt gggactttct cgagttttac      720

cagccgtatt ttaacaaggt cggcgggaag atcgtgctgg atgccaagta cagcgggcag      780

acgccgccgc aggtcgcgct cgtcacgaag atcgcggggt acgccgcggg gcgcttcggc      840

gcgacgaaga acatcacgca gatcatctac gaggtcattc gatatgttaa gggcatcaag      900

caggagatca agatcaggtg cgacaagagc tttaccctca acctcgcgga gtacgacgcg      960

ttccgcgacc aggtcacatc gagcccgatg gcgcactctg taaccgactt gacgcacgac     1020

gccttctcct acaaggccta cacgaacccc gtcttcaacg acctggaaaa cctgacctcc     1080

caaatcatca cctatgtcaa cgacgtatgc acttgtgacc gcgagcggct ggacgacgat     1140

ccgttcaact cggtctttat tctgaaaaat cgcgacggcc tcaacttcgc cgacgcgtgc     1200

gacctcgttg tcggcgaggt cgtaaagaag acggcgaagt tcctggagac taaggatagg     1260

cttcttgcgg aagctgctga tgaagagggg agggcggcta ttgcgcagaa gatcaagacg     1320

cgcgaggact cgatcatcgg gtacatgatg cacgaggttt gctgcgtgac ggacgggtat     1380

gcgcgcgacc acaagccgct gatgaaagag tatctggaga aggcgatgtt tggtgaggcg     1440

agcagcggag ccctgtag                                                   1458


<210>  19
<211>  1440
<212>  DNA
<213>  Rhodophysema elegans

<400>  19
atgtctcctt cggcctttct ccccctagcc gggcccttag ccttccggcg ggcctcgctg       60

cagcgtctaa atcatacccg taccctccca cccaccgtcg ctccgtcccg cgcaccaatg      120

acgcccttca tggtcgacac cagccgcggg caccctgcta cagcagcccc acctatgggc      180

gcgcgccgca gcctgacgct gacggacccg gccgatctgg cgctcatggt ctcccacctg      240

aagcgcgagc atttcgacaa gggcgactac ctttacccga tcaaaaccgt atgcgccggc      300

gaggacatcg acgtccgctt cgctatcccc ttcgagccgc gcctcagctc gcactatgcg      360

gccctgtaca actcgcgaaa cgatcgcgcc aagctttacg ccgtcccgcc gcggacgact      420

gacatgcgta agtacaaccg catcaactgt gagaagatgg gcgccctgct cgcgcccaac      480

tctgcctacg gcgacacaga ggccgtctct ctcttctact cgatgatgta ctacctcaac      540

gaccagacgg cgatctgcaa gctgcccgag gacgaaatcg agcttcgcct cgtcgacgag      600

ctcaacgaca acgtgctcca atatctcggc atcttcctct ccgtcttcga gccgcgcgat      660

gccgctgatt tggagcgtat ctgggacttt ctagactttt accagccgta cttccgcaag      720

gccggccgga ggatcgtgct ggacgacaaa tacctcgggc agacgccgcc gcaggtcgcg      780

cttgtcacaa cgatcgcaaa ctacgtcgcc gaacgcttcg gcgcgacgaa gaacatcacg      840

caggtcgtct acgaggtgat tcgctatgtt aagggcatca agcaggaggt gaagatcagg      900

tgcgacaagg gattcaccct ctcactcgcc gagtacgacg atttccgcga ccaggtcacg      960

tccagcccga tggcgcactc cgtgaccgac ctcacccacg acgccttctc ctacgaggca     1020

tataagaacc cggtcttcaa ctccctggag aacctgacct cccaggtcat tacctacatc     1080

aacgacgtgt gcacgtgtga ccgagagcgg ctagacaagg acccgtttaa ctcggtgttc     1140

attctgaaag accgcgacgg tctgaacttc gccgacgcgt gcgacctcgt cgtcgccgag     1200

atcgaaaaga aaatggcaaa gttcctcgag acgaagaagc agcttctgtc ggaggctgct     1260

gatgaagagc gcagaacagc catggcgcag atgatcaaga cgcgggagga ctcgatcatc     1320

ggctacatga tgcacgaggt ctgctgcgtg acggacgggt atgcgcgcga ccacaagccg     1380

aagatgaagg agtatctgga gaaggcgatg tttggggagg tgagcaggga agccatgtag     1440


<210>  20
<211>  1356
<212>  DNA
<213>  Grateloupia filicina

<400>  20
atgaatttga tcctccgcag taacatgcct attttcccat cttgcgcttt tctctcatcc       60

tcaaccacta ccactttcat tcaacctctt gtcaaacgta tccactccgt ttgccccaat      120

ccagtacgcc atgagccagt ttcagcaaac cgtcgcctag tcatgcgact tgcctggaat      180

cctacaccca ctcaacaact taccacagag agtcctaccg aagcactttc ccgccttcaa      240

accactggac taaccctgac tgacccgaag gacctttact ggatgaccga ttttttggaa      300

caacaatttt actcaaaaag aaaccccaac tatcccatga aaaccatctg cgacggcgaa      360

ctcatcgaga ccgaatttca ctgtccatac caacccaaac tcagccctca ttatatgagg      420

ttgtgcaaca ctaagcatga aagatctctc ttgtactcaa ttccaccaaa caccacagat      480

atgaacaagt acaaccgaat taattgcgag aagttcgcct ctttggtagc cccgaattcc      540

aattatgaag atacagaggc tgttgccctc atgtactcca tgatgtacta tctcaatgat      600

cagactgccc atcttaaact tcctgaggat atgattcagc ctcaacttat tgatgaactc      660

aacgataacg tattgcagta tctcgctgtg tttctaagca tcttcgaacc ccgcgatccg      720

gaagatttgg agcgcatctg ggacttctta gacttttatc agaagtactt caacaaaata      780

gacggaaaga ttgtcttgga tgaaaagtac aaaggaccag tcccgcctca aattgctttg      840

attaacaaaa tcacccaata tatctcgaag agatttgctc cgacgaagaa cataactcag      900

ttcatctacg aggtcatcag atacatcaag gggatcaagc aagaggtcta cattcgatgt      960

gataagagtt ttactctttc tctcaaggag tatgatgaat ttcgtgatca agtgacgtcc     1020

agcccgatgg cacatgctgt gacagatatg acctatgaca acttctctta taagctctac     1080

ctgaacccgc ttttcaccga actggagaat ctgacttcag aactgatcac ctacttcaac     1140

gacgtttgca catgtgatcg cgagagactg gacaatgatc ctttcaactc tgtgttcatt     1200

ctgaaagacc tttatggtgg tacctatgca caaagttgtg atcttgtcgt gagcgaaacg     1260

cgcaaaaagt tctctaaatt tttggagatc aaacaaattc ttcttgatgg ggcagcagac     1320

gaaaccgaga aacaagctat tgcccagatg attaag                               1356


<210>  21
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
ggtgccgcgc ggcagccata tgagtattac cactatgaaa ggagttacat c                51


<210>  22
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
ggtggtggtg gtgctcgagt taatttgtcg ccttgagttt cttaaag                     47


<210>  23
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
ggtgccgcgc ggcagccata tgacagtaag taagtacaac ggtgttg                     47


<210>  24
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
ggtggtggtg gtgctcgagt taaaggtagt atccttcatg aaatttg                     47


<210>  25
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
ctgtacttcc aatccggatc catgacttct ttcgatttcg tcgctaagac tttc             54


<210>  26
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
ggtggtggtg gtgctcgagt tagacgtagt accccgagtg aaactttgc                   49


<210>  27
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
ctgtacttcc aatccggatc catgcctgtg tataatggta cgtcacaagc                  50


<210>  28
<211>  53
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
ggtggtggtg gtgctcgagt tacaggtagt aaccttcatg gaatttgttc ttg              53


<210>  29
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
ctgtacttcc aatccggatc catggcggtg tacaatggcg tctcgcagg                   49


<210>  30
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
ggtggtggtg gtgctcgagc tatagataat agccctcgtg gaacttattt ttcacg           56


<210>  31
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
catatggctg ccgcgcggca cc                                                22


<210>  32
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
ctcgagcacc accaccacca ccactgag                                          28


<210>  33
<211>  1057
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
atgcctgtgt ataatggtac gtcacaagca ttcaattttg cgccgctgca cccagatagt       60

ttgaattggt gcccaaagtc gagtcttcct ccagaaattc ctgtagtgga tctgtcaaaa      120

cttaattctg aagccgagct ggcacaattt cttgtggaca ttcgtaagag cgggttgttt      180

tatgtagtca atcatggtgt cccggaagaa ctttctattg ggtgttacaa tcgcttccgt      240

caattctgta acattcctga ggaccaacgt gcggaatact cgaccgacca tcattttgta      300

aacgggggct acatgccgta taagagttcc agcatcggca aggcaaataa aggtaaatct      360

caaaaggact ttgtggttaa atacttctgg cgtggaccgc gcgttgagaa ccgtagtccg      420

gatgctgatt tcaagagcta tcacgacgaa taccaccgtc gcacagctga tatcgctaac      480

agcgtgatta ctaaaattct tcaggccctg acgacgcgtt ttcctgactt tgaccctgct      540

gaatataaag ataacattaa ttcccatcat atgttcttct cgaaccgcct ttacccagac      600

aacgaacctg agaaaggcga gaatgtagaa taccgtttag taccgcaccg tgacctgagc      660

ttcgtgaccc ttgctcacca aatcccggcg gacaacggtt accaaggcct tttcgttttt      720

accggcgatg ggaagaaggt ttgcgtgcct ccgattcgta acagctatct tgtcttcatg      780

ggacaggcaa tgtcgtatct gacgaataag tacttacctg cagggttgca tggcgtggat      840

tttcctgaaa agaactgttt cgaggggtct gaacgctcct ctcttatctc attttacgaa      900

cctcacgatc atatgatgcc cagcaaagca cttacaccta aggatgatga gatcttcgat      960

cgtggttgtt cgttctttga tgacatcggc gtggacaaaa cagggacgac ctatatgtat     1020

gtcaagaaca aattccatga aggttactac ctgtaag                              1057


<210>  34
<211>  1053
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
atgacttctt tcgatttcgt cgctaagact ttcgattttg ctcccgtcaa agctgacgag       60

ttgaagtggt atccacgttc cgcgttacca ccagaaattc ctgtaattga tttgaacaac      120

gtcaatacgg aggaggagct tgcacagttc ctggtggaca tccgcaagtc tggacttttc      180

tacgttgtca accacgatat cccggaggaa atctcaatcc agacgtacaa cgaatttcgt      240

gagttttgta aattgccaga agaggcccgc caaaaataca atactgatcg ctgcttcttc      300

aatgggggat atgttccatt caaagccacg agcattaatg ggggtaataa gaacaaacag      360

caacgcgact ttgtcgtgaa gtttttctgg cgcggcccac acgtggtcaa tcgttccccc      420

aatgaacgct ttgccaaatg gcaccatcag tatcatacac gcactgctga attaggtgaa      480

aaggtcatga ccacaatcgc aaaagctttg aagacgcgct ttcctgactt cgacccggcc      540

gaactggagg acaatgtgaa ccctcacaac atgatttttt ctaaccgcat ttatccggaa      600

ttcccaccca gtgaagggga ggatgctgag tatcgcctga ccccccaccg tgatatttcc      660

tacattaccc ttgtgaatca gactcctgcc aataacggat tcaaagcatt atttatcgta      720

accggggacg gcgaacgcgt ttacgtccct cctatccgca actcttactt ggtattcatc      780

gggcagagct tgagctacct taccaataaa taccttccag cggcacttca cggggtcgct      840

tttccggacg gcaatcttga gggttgcgag cgtgcctcac tggtgtcttt ctatgaaccg      900

tatgatcgca tggtcccatc gaaaaatatc aaaccaacgg cagaagagat cgctccaaaa      960

tcctgctcct tctatgattc gattgggtgt gacaagacag gaactacctt tactgatgtt     1020

cgtgcaaagt ttcactcggg gtactacgtc taa                                  1053


<210>  35
<211>  482
<212>  PRT
<213>  Pseudo Nitzschia multiseries

<400>  35

Met Lys Phe Ala Thr Ser Ile Val Ala Ala Ile Ala Thr Thr Gly Ala 
1               5                   10                  15      


Ala Phe Thr Val Ile Pro Gln Lys Leu Ser His Pro Ser Gln Leu Asn 
            20                  25                  30          


Ala Leu Asn Thr Met Gly Ser Ile Ser Ser Ile Thr Ala Glu Ser Pro 
        35                  40                  45              


Lys Glu Val Leu Ser Arg Val Gln Asp Ala Gly Leu Thr Leu Thr Asn 
    50                  55                  60                  


Pro Asn Asp Leu Tyr Trp Met Val Asp Phe Leu Lys Glu Lys Tyr Tyr 
65                  70                  75                  80  


Asp Asn Gly Asp Tyr Tyr Tyr Pro Ile Lys Thr Val Cys Asp Gly Glu 
                85                  90                  95      


Ser Ile Asp Val Lys Phe Tyr Cys Pro Phe Glu Pro Ser Leu Ser Pro 
            100                 105                 110         


His Tyr Leu Glu Leu Tyr Gly Ser Arg Asp Glu Arg Ala Ser Ile Tyr 
        115                 120                 125             


Glu Thr Thr Met Lys Lys Tyr Asn Arg Ile Asn Ser Glu Lys Thr Ser 
    130                 135                 140                 


Ala Ile Cys Thr Pro Tyr Ser Ser Tyr Gly Asp Thr Gln Ile Val Ala 
145                 150                 155                 160 


Tyr Phe Tyr Ser Met Met Tyr Tyr Ile Asn Asp Gln Thr Ala His Leu 
                165                 170                 175     


Lys Leu Pro Glu Ser Glu Ile Glu Ser Glu Leu Ile Asp Ile Leu Asn 
            180                 185                 190         


Asp Asp Ile Leu Ile Tyr Leu Asn Glu Phe Met Ser Ile Phe Glu Pro 
        195                 200                 205             


Glu Asp Ala Gln Asp Leu Glu Arg Ile Trp Asp Phe Leu Asp Phe Tyr 
    210                 215                 220                 


Gln Pro Tyr Phe Ser Lys Val Asp Gly Lys Ile Val Leu Asp Glu Lys 
225                 230                 235                 240 


Tyr Leu Val Arg Thr Pro Ser Gln Met Pro Leu Ile Lys Thr Ile Cys 
                245                 250                 255     


Glu Tyr Val Ser Glu Gln Phe Ala Pro Ser Lys Asn Ile Thr Gln Val 
            260                 265                 270         


Ile Trp Glu Val Val Arg Tyr Ile Lys Gly Val Lys Asp Glu Ile His 
        275                 280                 285             


Ile Arg Gly Asp Lys Ser Phe Thr Leu Ser Leu Gln Glu Tyr Asp Asp 
    290                 295                 300                 


Phe Arg Asp Lys Val Thr Ala Ser Pro Met Ala His Ala Val Ser Asp 
305                 310                 315                 320 


Leu Thr His Glu Arg Phe Ser Tyr Glu Ala Tyr Thr Asn Pro Ala Phe 
                325                 330                 335     


Met Glu Leu Glu Asn Arg Cys Ser Glu Ile Ile Thr Tyr Phe Asn Asp 
            340                 345                 350         


Val Cys Thr Ser Asp Arg Glu Arg Leu Asp Glu Asp Pro Phe Asn Ser 
        355                 360                 365             


Val Phe Ile Leu Met Asp Leu Asp Pro Ser Leu Asn Phe Ala Lys Ser 
    370                 375                 380                 


Cys Asp Val Val Val Glu His Ala Tyr Asn Lys Met Gln Ala Phe Leu 
385                 390                 395                 400 


Lys Leu Lys Glu Glu Ile Leu Glu Ser Ala Ser Asp Glu Glu Glu Arg 
                405                 410                 415     


Leu Ala Leu Ala Arg Met Ile Lys Thr Arg Glu Asp Ser Leu Ile Gly 
            420                 425                 430         


Tyr Val Leu His Glu Val Cys Cys Val Glu Asp Gly Tyr Ala Arg Asp 
        435                 440                 445             


His Lys Pro Leu Met Lys Ala Phe Leu Glu Glu Glu Ile Thr Lys Ser 
    450                 455                 460                 


Leu Ala Glu Lys Val Lys Phe Asn Pro Val Glu Ser Glu Ser Val Arg 
465                 470                 475                 480 


Leu Asn 
        


<210>  36
<211>  373
<212>  PRT
<213>  Pseudo Nitzschia multiseries

<400>  36

Met Thr Val Ala Ile Asn Asn Glu Thr Val Val Leu Thr Pro Asn Glu 
1               5                   10                  15      


Asp Asp Val Gln Val Asn Lys Gly Lys Thr Leu Glu Thr Ser Phe Pro 
            20                  25                  30          


Pro Leu Lys Gly Asp Asp Leu Lys Trp Phe Pro Arg Ser Ser Leu Pro 
        35                  40                  45              


Ala Glu Ile Pro Ala Ile Asp Ile Gly Lys Val Ser Thr Lys Glu Glu 
    50                  55                  60                  


Leu Glu Gln Phe Leu Val Asp Ile Arg Lys Ser Gly Leu Phe Tyr Ile 
65                  70                  75                  80  


Val Asn His Gly Val Pro Glu Glu Val Ser Ile Asn Val Tyr Asn Ala 
                85                  90                  95      


Phe Arg Glu Phe Ile Ser Thr Thr Thr Glu Glu Glu Arg Met Lys Tyr 
            100                 105                 110         


Tyr Thr Asp Thr His Phe Gln Asn Gly Gly Tyr Val Pro Phe Gln Gly 
        115                 120                 125             


Ser Ser Ile Arg Gly Gly Asn Leu Gly Lys Pro Gln Lys Asp His Val 
    130                 135                 140                 


Val Lys Tyr Phe Trp Arg Gly Pro Glu Val Ile Asn Arg Thr Pro Asn 
145                 150                 155                 160 


Glu Lys Phe Thr Glu Ala His Asn Met His His Thr Glu Thr Phe Lys 
                165                 170                 175     


Val Ala Glu Lys Val Ile Arg Thr Ile Phe Lys Ala Leu Lys Leu Arg 
            180                 185                 190         


Phe Pro Asp Phe Asp Pro Met Glu Phe Glu Asn Thr Ile Asn Ser Lys 
        195                 200                 205             


Lys Met Phe Phe Thr Asn Arg Ile Tyr Pro Gln Ala Glu Pro Ser Asp 
    210                 215                 220                 


Glu Glu Glu Ile Thr His Arg Leu Val Pro His Leu Asp Thr Ser Phe 
225                 230                 235                 240 


Ile Thr Leu Ala Asn Gln Val Pro Ala Asp Asn Gly Phe Gln Gly Leu 
                245                 250                 255     


Phe Val Glu Thr Gly Asp Gly Lys Lys Val Lys Val Pro Gly Ile Arg 
            260                 265                 270         


Asn Ser Tyr Leu Val Phe Ile Gly Gln Ser Leu Ser Tyr Leu Thr Lys 
        275                 280                 285             


Asn Tyr Leu Pro Ser Ala Leu His Gly Val Asp Lys Pro Pro Ser Asp 
    290                 295                 300                 


Leu Phe Glu Gly Ser Glu Arg Ser Ser Leu Ile Thr Phe Tyr Glu Pro 
305                 310                 315                 320 


Ala Glu Ile Ile Ile Pro Ser Lys Asn Ile Asn Pro Asn Pro Glu Glu 
                325                 330                 335     


Thr Ser Glu Ser Cys Pro Phe Phe Tyr Asp Ile Gly Leu Thr Val Asn 
            340                 345                 350         


Asp Pro Glu Gly Thr Thr Trp Asp Phe Val Lys Asn Lys Phe Ile Thr 
        355                 360                 365             


Gly Tyr Tyr Ala Asp 
    370             


